CN112986434B - Supplementary quick screening device of biguanide class material for blood sugar reducing capsule - Google Patents
Supplementary quick screening device of biguanide class material for blood sugar reducing capsule Download PDFInfo
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- CN112986434B CN112986434B CN202110199538.XA CN202110199538A CN112986434B CN 112986434 B CN112986434 B CN 112986434B CN 202110199538 A CN202110199538 A CN 202110199538A CN 112986434 B CN112986434 B CN 112986434B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/86—Signal analysis
- G01N30/8675—Evaluation, i.e. decoding of the signal into analytical information
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
- G01N2030/062—Preparation extracting sample from raw material
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Abstract
The utility model provides a supplementary quick screening device of biguanide class material for blood sugar reducing capsule, relates to the automation equipment field, including a mounting bracket, the mounting bracket includes mounting panel and uide bushing, is equipped with multiunit rabbling mechanism, two on last mounting panel be equipped with configuration mechanism between the uide bushing, it is equipped with grinding mechanism to go up the mounting panel right side. And a shaking-up mechanism is arranged on one side of the mounting rack. The invention can rapidly prepare the sample solution and the solution of the sample to be detected, innovatively detect MH, PH and BH at one time, and rapidly analyze and determine the sample. The detection time and the labor cost are reduced.
Description
Technical Field
The invention relates to the field of automation equipment, in particular to a device for rapidly screening biguanide substances for assisting blood sugar reducing capsules.
Background
The health-care food can be divided into two categories of functional health-care food and nutrient supplement, and the blood sugar-reducing health-care food is one of the functional health-care foods. The health food for reducing blood sugar can only be used as an auxiliary conditioning means for diabetes patients, but not as a main method for reducing blood sugar. Because biguanide drugs have good blood sugar reducing effect, the biguanide drugs are often added into blood sugar reducing health-care food by merchants, but biguanide substances have no blood sugar reducing effect on normal people and can also accumulate in vivo to cause lactic acidosis.
According to the relevant regulations of Chinese food and drug management laws, the health food can not be used for replacing medicines and can not be added with western medicine components in any form. The detection methods of metformin hydrochloride, phenformin hydrochloride and buformin hydrochloride are provided in standards of 'supplement and inspection method for illegal addition of chemicals in hypoglycemic Chinese patent medicines' and 'supplement and inspection method for illegal addition of buformin hydrochloride in hypoglycemic Chinese patent medicines' of the State food and drug administration. The currently common instrument detection technologies include spectrophotometry, thin-layer chromatography, capillary electrophoresis, high performance liquid chromatography-mass spectrometry and the like. The method for screening and verifying the illegal addition of chemical drugs in the hypoglycemic health-care food by the national food and drug administration drug inspection and supplement inspection is time-consuming and tedious and requires 3 liquid phase systems in total.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a rapid screening device for biguanide substances for assisting a blood-glucose-reducing capsule, which can screen 3 biguanide chemicals possibly existing in blood-glucose-reducing health-care food at one time and reduce the labor intensity of related detection organs.
The technical scheme adopted by the invention for solving the technical problem is as follows:
the utility model provides a supplementary quick screening device of biguanide class material for blood sugar-reducing capsule, includes a mounting bracket, the mounting bracket includes two vertical poles, two fixedly connected with slide rail between the vertical pole, sliding fit has the slider on the slide rail, be equipped with the supporting seat on the slider, be equipped with the constant head tank on the supporting seat, it has the even pipe of sample to peg graft in the constant head tank, fixedly connected with uide bushing on the vertical pole, sliding fit has the guide bar, two in the uide bushing the guide bar upper end is equipped with the mounting panel, is equipped with reset spring between last mounting panel and uide bushing, is equipped with multiunit rabbling mechanism, two on the last mounting panel be equipped with configuration mechanism between the uide bushing, it is equipped with grinding mechanism to go up the mounting panel right side. And a shaking mechanism is arranged on one side of the mounting rack.
Furthermore, the reset spring is sleeved on the guide rod.
Further, the stirring mechanism comprises a stirring motor, the stirring motor is connected with a stirring shaft, and a plurality of stirring teeth are arranged on the stirring shaft.
Furthermore, the configuration mechanism comprises a central plate, a plurality of through holes are formed in the central plate, configuration pipes are inserted in the through holes, the central plate is provided with a clamping mechanism, a liquid outlet pipe is arranged at the bottom of each configuration pipe, and a liquid outlet valve is arranged on each liquid outlet pipe.
Further, fixture includes a fixed block, install fixed spring on the fixed block, fixed spring is connected with fixed grip block, two the centre gripping has the configuration pipe between the fixed grip block.
Furthermore, a plurality of clamping grooves matched with the fixed clamping plates are formed in two sides of the configuration pipe.
Furthermore, a central rotating shaft is installed on the guide sleeve, the central rotating shaft is connected with a central plate, a slot is formed in the side wall of the central plate, an inserting rod is arranged in the slot in a sliding fit mode, a positioning spring is arranged between the inserting rod and the bottom of the slot, a positioning hole is formed in the guide sleeve, and the inserting rod is inserted into the positioning hole to limit rotation of the central plate relative to the guide sleeve.
Further, grind the mechanism and include a vertical guide rail, sliding fit has the guide block on the vertical guide rail, threaded connection has adjust knob on the guide block, adjust knob can make the guide block remove and be located a department on vertical guide rail along vertical guide rail, is equipped with the layer board on the guide block, be equipped with the grinding alms bowl on the layer board, be equipped with the grinding motor on last mounting panel right side, the output shaft of grinding motor has the grinding rod.
Further, shake even mechanism and include an outer tube, interior pole and location knob, outer tube fixed connection is on last mounting panel, location knob can make interior pole remove and be positioned a department on the outer tube along the outer tube, interior pole tip rotates to be connected with and shakes even board, shake and be equipped with between even board and the interior pole and shake even spring, be equipped with vibrating motor shaking even board bottom, peg graft on shaking even board and have shaken even bottle, wherein shake even bottle top and be equipped with the shutoff stopper, be equipped with a filter screen in shaking even bottle, be equipped with a plurality of filtration pores of crossing on the filter screen.
Furthermore, shake even mechanism and include one and shake even bottom plate, be provided with two fixing bases shaking even bottom plate, be equipped with the turning block at two fixing base intermediate positions, the turning block articulates on shaking even bottom plate, and the turning block takes place relative rotation for shaking even bottom plate, the symmetry is provided with the connecting rod on the turning block side, installs swing motor at the connecting rod tip, is provided with first eccentric wheel on the swing motor, still fixed mounting has a swinging arms on turning block upper portion, the swinging arms lays with the connecting rod mutually perpendicular. The swing rod is provided with a plurality of shaking bottles, the middle part of the swing rod is fixed on the rotating block, and a telescopic mechanism is arranged between the fixed seat and the swing rod and comprises a telescopic cylinder, a sliding plate, a first spring and a telescopic rod. Install the slide in telescopic cylinder, the slide slides in telescopic cylinder, is provided with a telescopic link on the slide, and nested there is first spring on the telescopic link, and the telescopic link passes the through-hole on the telescopic cylinder end cover and is in the same place with swinging arms end connection, and telescopic cylinder is connected with the fixing base.
Furthermore, the swing motor is provided with two output shafts, two output shafts are provided with first eccentric wheels, and a ribbed plate or a support rod is connected between the two first eccentric wheels.
The beneficial effects of the invention are: the invention can rapidly prepare the sample solution and the solution of the sample to be detected, innovatively detect MH, PH and BH at one time, and rapidly analyze and determine the sample. The detection time and the labor cost are reduced.
Drawings
FIG. 1 is a schematic view of the structure of the present invention;
FIG. 2 is an enlarged view of a portion A of FIG. 1;
FIG. 3 is a partial enlarged view of the portion B in FIG. 1;
FIG. 4 is a front view of a second embodiment of a shake-up mechanism;
fig. 5 is a schematic three-dimensional structure diagram of a second embodiment of the shake-up mechanism.
Detailed Description
As shown in fig. 1 to 3, a supplementary quick screening device of biguanide material for blood sugar lowering capsule, includes an installation frame, the installation frame includes two vertical poles 11, two fixedly connected with slide rail 12 between the vertical pole, sliding fit has slider 13 on the slide rail, be equipped with supporting seat 14 on the slider, be equipped with constant head tank 15 on the supporting seat, it has even pipe 16 of sample to peg graft in the constant head tank.
The vertical rod is fixedly connected with a guide sleeve 17, guide rods 18 are arranged in the guide sleeve in a sliding fit mode, upper mounting plates 19 are arranged at the upper ends of the two guide rods, and a reset spring 110 is arranged between the upper mounting plates and the guide sleeve.
The scheme is refined, and the reset spring is sleeved on the guide rod.
A plurality of groups of stirring mechanisms are arranged on the upper mounting plate. The stirring mechanism can be used for stirring the biguanide sample solution. The stirring mechanism comprises a stirring motor 21, the stirring motor is connected with a stirring shaft 22, and a plurality of stirring teeth are arranged on the stirring shaft.
In cooperation with the guide sleeve, a configuration mechanism for configuring the biguanide chemicals is arranged between the two guide sleeves.
The configuration mechanism comprises a central plate 32, a plurality of through holes 33 are formed in the central plate, configuration pipes 34 are inserted in the through holes and can be used for configuring MH, PH and BH solutions. Wherein the purity of Metformin Hydrochloride (MH) standard, phenformin Hydrochloride (PH) standard and Buformin Hydrochloride (BH) standard is more than 99% (China pharmaceutical and biological products institute).
Furthermore, the central plate is provided with a clamping mechanism, and the clamping mechanism can clamp the distribution pipe and adjust the relative position of the distribution pipe relative to the central plate. Fixture includes a fixed block 35, install fixed spring 36 on the fixed block, fixed spring is connected with fixed grip block 37, two the centre gripping has the configuration pipe between the fixed grip block. The bottom of the configuration pipe is provided with a liquid outlet pipe 313, and the liquid outlet pipe is provided with a liquid outlet valve 314.
The scheme is optimized, a plurality of clamping grooves 38 matched with the fixed clamping plates are formed in two sides of the configuration pipe, and the fixed clamping plates can be inserted into different clamping grooves to further enhance the clamping capacity and adjust the vertical height of the configuration pipe.
Furthermore, a central rotating shaft 31 is installed on the guide sleeve, and the central rotating shaft is connected with a central plate 32. Through the design of the central rotating shaft, the rotation of the central plate can be conveniently carried out so as to add MH, PH and BH solids.
The scheme is refined, a slot 39 is arranged on the side wall of the central plate, an inserting rod 310 is in sliding fit in the slot, a positioning spring 311 is arranged between the inserting rod and the bottom of the slot, and in cooperation with the positioning spring, a positioning hole 312 is arranged on the guide sleeve, and the inserting rod can be inserted into the positioning hole to limit the rotation of the central plate relative to the guide sleeve.
In at least one embodiment, the right side of the upper mounting plate is provided with a grinding mechanism.
The grinding mechanism comprises a vertical guide rail 51, a guide block 52 is in sliding fit with the vertical guide rail, an adjusting knob 53 is in threaded connection with the guide block, and the adjusting knob can enable the guide block to move along the vertical guide rail and be positioned at one position on the vertical guide rail. A carrier plate 54 is arranged on the guide block, and a grinding bowl 55 is arranged on the carrier plate. Be equipped with grinding motor 56 on the upper mounting panel right side, grinding motor's output shaft 57 is connected with grinding rod 58, grinding rod can insert in the grinding alms bowl for grind into powder to the testing sample.
In at least one embodiment, the left side of the upper mounting plate is provided with a shaking mechanism.
The shaking mechanism comprises an outer tube 61, an inner rod 63 and a positioning knob 62, the outer tube is fixedly connected to the upper mounting plate, and the positioning knob can enable the inner rod to move along the outer tube and be positioned at one position on the outer tube. The end part of the inner rod is rotatably connected with a shaking plate 64, a shaking spring 65 is arranged between the shaking plate and the inner rod, and the bottom of the shaking plate is provided with a vibrating motor 66.
The vibrating motor can drive the shaking-up plate to vibrate.
A shaking bottle 67 can be inserted on the shaking plate. Wherein the top of the shaking bottle is provided with a sealing plug 68, a filter screen 69 is arranged in the shaking bottle, and the filter screen is provided with a plurality of filter holes 691.
In another embodiment, the shake-up mechanism is placed on the ground as shown in fig. 4 and 5.
The shaking mechanism comprises a shaking bottom plate, and two fixed seats 71 are arranged on the shaking bottom plate.
The fixed seats 71 are spaced at a certain distance for installing other parts of the shaking mechanism.
A rotating block 79 is arranged in the middle of the two fixed seats 71, the rotating block 79 is hinged to the shaking bottom plate, and the rotating block 79 rotates relative to the shaking bottom plate. The side surface of the rotating block 79 is symmetrically provided with a connecting rod 78, the end part of the connecting rod 78 is provided with a swing motor 710, and the swing motor 710 is provided with a first eccentric wheel 77.
According to an optimized design, the swing motor 710 is provided with two output shafts, two output shafts are respectively provided with a first eccentric wheel 77, and a ribbed plate or a support rod is connected between the two first eccentric wheels 77.
A swing lever 76 is also fixedly mounted on the upper portion of the pivot block 79, and the swing lever 76 and the connecting rod 78 are arranged perpendicular to each other. A plurality of shaking bottles 67 are arranged on the swinging rod.
The swing lever 76 is fixed at its middle portion to the rotating block 79 and swings in accordance with the rotation of the rotating block 79.
A telescopic mechanism is provided between the fixed base 71 and the swing lever 76, and the telescopic mechanism includes a telescopic cylinder 72, a slide plate 73, a first spring 74, and a telescopic rod 75. A sliding plate 73 is installed in the telescopic cylinder 72, the sliding plate 73 slides in the telescopic cylinder 72, a telescopic rod 75 is arranged on the sliding plate 73, and a first spring 74 is nested on the telescopic rod 75. The telescopic rod passes through a through hole on the end cover of the telescopic cylinder 72 and is connected with the end part of the swinging rod 75. The telescopic tube 72 is connected with the fixed seat 71.
The working steps are as follows:
s1, accurately weighing 10.0mg of MH, PH and BH standard substances respectively, putting the MH, PH and BH standard substances into a preparation tube 34, diluting the MH, PH and BH standard substances with methanol, and then uniformly shaking the MH, PH and BH standard substances with a stirring shaft to prepare a standard stock solution with the concentration of 0.5 mg/mL;
and S2, adjusting the position of the sample homogenizing tube, then respectively dripping l0mL of MH, PH and BH standard stock solutions into the sample homogenizing tube, and mixing to prepare a mixed standard solution.
And S3, transferring a certain amount of the mixed standard stock solution, diluting the mixed standard stock solution by using methanol to prepare mixed standard stock solutions with different concentrations, injecting 10 mu L of sample, taking the concentration of the standard stock solution as a horizontal coordinate, taking a chromatographic detection peak area as a vertical coordinate, and taking a standard working curve to obtain a linear regression equation of each curve.
And S4, the sample is one or more of a thatch salt, a American ginseng soft capsule, a radix astragali, rhodiola rosea, chromium yeast soft capsule, a polygonatum rhizoma and Chinese yam composite particle and a kudzu root, balsam pear and chromium capsule, and can be purchased from a Yifengtang pharmacy. Taking 4 capsules, removing outer capsule shells, grinding in a grinding mechanism, placing the ground medicinal powder in a shaking mechanism, extracting with methanol as an extractant at 25mL, performing ultrasonic extraction at 50 deg.C under 400W for 30min, cooling to room temperature, diluting to scale with the extractant, shaking, and filtering with a 0.45 μm microporous filter screen.
And S5, precisely measuring 5 mu L of each of the standard solution and the test solution (the test sample is divided into 2 groups, 2 mixed standard solutions with different concentrations are added), injecting the solution into a liquid chromatograph-mass spectrometer, obtaining the chromatogram of the standard sample and the test sample and the mass spectrum peak of the mass spectrum test solution and the standard solution are inconsistent, determining that 5 samples do not contain MH, BH and PH, and if the two samples are consistent, indicating that the 5 samples contain related components.
Except for the technical features described in the specification, the method is known by the technical personnel in the field.
Claims (1)
1. The device for rapidly screening the biguanide substances for the auxiliary hypoglycemic capsules is characterized by comprising a mounting rack, wherein the mounting rack comprises two vertical rods, a slide rail is fixedly connected between the two vertical rods, a slide block is in sliding fit on the slide rail, a supporting seat is arranged on the slide block, a positioning groove is arranged on the supporting seat, a sample homogenizing tube is inserted in the positioning groove, a guide sleeve is fixedly connected on the vertical rods, guide rods are in sliding fit in the guide sleeve, an upper mounting plate is arranged at the upper ends of the two guide rods, a reset spring is arranged between the upper mounting plate and the guide sleeve, a plurality of groups of stirring mechanisms are arranged on the upper mounting plate, a configuration mechanism is arranged between the two guide sleeves, a grinding mechanism is arranged at the right side of the upper mounting plate, a shaking mechanism is arranged at one side of the mounting rack, and the stirring mechanism comprises a stirring motor, the stirring motor is connected with a stirring shaft, a plurality of stirring teeth are arranged on the stirring shaft, the configuration mechanism comprises a central plate, a plurality of through holes are arranged on the central plate, a configuration pipe is inserted in the through holes, a clamping mechanism is arranged on the central plate, a liquid outlet pipe is arranged at the bottom of the configuration pipe, a liquid outlet valve is arranged on the liquid outlet pipe, the clamping mechanism comprises a fixed block, a fixed spring is arranged on the fixed block, the fixed spring is connected with a fixed clamping plate, the configuration pipe is clamped between the two fixed clamping plates, a plurality of clamping grooves matched with the fixed clamping plates are arranged on two sides of the configuration pipe, a central rotating shaft is arranged on the guide sleeve and connected with the central plate, slots are arranged on the side wall of the central plate, inserting rods are matched with the slots in a sliding manner, and positioning springs are arranged between the inserting rods and the bottoms of the slots, be equipped with the locating hole on the uide bushing, the inserted bar inserts the rotation of restriction well core plate for the uide bushing in the locating hole, grind the mechanism and include a vertical guide rail, sliding fit has the guide block on the vertical guide rail, threaded connection has adjust knob on the guide block, adjust knob can make the guide block remove and be located a department on vertical guide rail along vertical guide rail, is equipped with the layer board on the guide block, be equipped with the grinding alms bowl on the layer board, be equipped with grinding motor on last mounting panel right side, grinding motor's output shaft has the grinding rod, shake even mechanism and include an outer tube, interior pole and location knob, outer tube fixed connection is on last mounting panel, location knob can make interior pole remove and be located a department on the outer tube along the outer tube, interior pole tip rotates and is connected with and shakes even board, it is equipped with even spring to shake between even board and the interior pole, is equipped with vibrating motor bottom shaking even board, pegs graft on shaking even board and has the even bottle, wherein even bottle top is equipped with the shutoff and blocks up, is equipped with a filter screen in shaking even bottle, be equipped with a plurality of filtration pore on the filter screen.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110199538.XA CN112986434B (en) | 2021-02-23 | 2021-02-23 | Supplementary quick screening device of biguanide class material for blood sugar reducing capsule |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110199538.XA CN112986434B (en) | 2021-02-23 | 2021-02-23 | Supplementary quick screening device of biguanide class material for blood sugar reducing capsule |
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| CN112986434A CN112986434A (en) | 2021-06-18 |
| CN112986434B true CN112986434B (en) | 2023-03-07 |
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2021
- 2021-02-23 CN CN202110199538.XA patent/CN112986434B/en active Active
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| CN108593789A (en) * | 2018-04-10 | 2018-09-28 | 张艺霖 | One kind sticking class medical product and cuts liquid device processed |
| CN208334291U (en) * | 2018-07-18 | 2019-01-04 | 南宁市第八人民医院 | It is a kind of while measuring the device that a variety of chemicals are illegally added in health food |
| CN109521009A (en) * | 2018-11-24 | 2019-03-26 | 陕西众策网络科技发展有限公司 | A kind of tinned fruit sulfur dioxide detection device |
| CN109682800A (en) * | 2018-12-24 | 2019-04-26 | 中国神华能源股份有限公司 | Detecting instrument |
| CN209646379U (en) * | 2019-01-17 | 2019-11-19 | 山东方明药业集团股份有限公司 | A kind of externally-applied soft ointment production filler mixing arrangement |
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