CN112973818A - Flow channel active valve control mechanism and micro-fluidic chip - Google Patents
Flow channel active valve control mechanism and micro-fluidic chip Download PDFInfo
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- CN112973818A CN112973818A CN202110469648.3A CN202110469648A CN112973818A CN 112973818 A CN112973818 A CN 112973818A CN 202110469648 A CN202110469648 A CN 202110469648A CN 112973818 A CN112973818 A CN 112973818A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
Abstract
The invention discloses a flow channel active valve control mechanism and a micro-fluidic chip. The flow channel active valve control mechanism comprises a valve control component, a limiting component and an action component, wherein the valve control component is provided with a valve control rod and a valve control elastic element, the valve control rod is used for opening or closing a flow channel of the microfluidic chip, and the valve control elastic element is connected with the valve control rod to assist the valve control rod to reset; the limiting part comprises a limiting rod and a limiting elastic part, the limiting elastic part is connected with the limiting rod and used for driving the limiting rod to move, and the limiting rod can be driven by the limiting elastic part to move so as to limit the valve control rod; the action component is used for being installed on a chip supporting plate of the microfluidic chip, is used for exerting action on the valve control rod to realize the movement of the valve control rod, and is also used for exerting action on the limiting rod to realize the movement of the limiting rod. The runner active valve control mechanism is miniaturized, simple in structure and high in overall reliability.
Description
Technical Field
The invention relates to the technical field of biological detection and immunodiagnosis, in particular to a flow channel active valve control mechanism and a micro-fluidic chip.
Background
In clinical analysis, when a disc-type microfluidic chip loaded with a substance containing a sample such as blood and various reagents is used, the blood sample or the reagents are injected into a reaction chamber in batches through flow channels under the driving of centrifugal force, and the liquid after a reaction for a certain period of time flows into a waste liquid chamber in batches through the flow channels. In order to prevent the blood sample or reagent from directly flowing into the waste liquid chamber without staying in the reaction chamber, an active valve control mechanism is required to be arranged on the flow channel between the reaction chamber and the waste liquid chamber for controlling the opening and closing of the flow channel. In the prior art, a linear motor scheme is adopted, the linear motor is fixed on a chip supporting disk of the microfluidic chip, and a flow channel of the chip is opened or closed by linear motion of a motor shaft of the linear motor. In actual use, the linear motor is heavy, the load of the microfluidic rotary driving motor can be greatly increased, the size of the linear motor is large, and the miniaturization design of a chip supporting disc is hindered; in addition, the linear motor rotates at a high speed along with the microfluidic chip, and a conductive slip ring needs to be added on a chip supporting plate of the microfluidic chip to supply power to the linear motor, so that the electrical complexity of the whole microfluidic chip system is increased, and the mode increasingly does not meet the requirement of active valve control in practical application.
Disclosure of Invention
Therefore, it is necessary to provide a flow channel active valve control mechanism and a micro-fluidic chip, which are beneficial to miniaturization of the micro-fluidic chip, reduce the load of the micro-fluidic chip, have a simple mechanical structure of a moving part, and improve the reliability of the whole mechanism.
A flow channel active valve control mechanism comprises a valve control component, a limiting component and an action component, wherein the valve control component is provided with a valve control rod and a valve control elastic component, the valve control rod is movably connected to a chip supporting plate of a microfluidic chip and used for opening or closing a flow channel of the microfluidic chip, and the valve control elastic component is connected with the valve control rod and used for assisting the valve control rod to reset; the limiting part comprises a limiting rod and a limiting elastic part, the limiting rod is movably connected to a chip supporting plate of the microfluidic chip, the limiting elastic part is connected with the limiting rod to drive the limiting rod to move, and the limiting rod can be driven by the limiting elastic part to move to limit the valve control rod; the action component is used for being installed on a chip supporting plate of a microfluidic chip, the action component is used for exerting action on the valve control rod to realize the movement of the valve control rod, and the action component is also used for exerting action on the limiting rod to realize the movement of the limiting rod.
In one embodiment, the extending direction of the valve control rod is perpendicular to the extending direction of the limiting rod, when the valve control elastic piece is in the reset state, the limiting elastic piece is in the compressed state, and the limiting rod is abutted against the valve control rod.
In one embodiment, the actuating component comprises a jacking rod, a jacking seat, a reset deflector rod, a deflector rod elastic piece, a deflector rod base and a jacking driver, the jacking rod is connected with the jacking seat, the jacking driver is connected with the jacking seat to drive the jacking seat to move, the jacking rod is opposite to the valve control rod, the reset deflector rod is elastically and movably connected to the deflector rod base through the deflector rod, the reset deflector rod is used for poking the limiting rod to extrude the limiting elastic piece to reset, when the jacking driver drives the jacking seat to move towards the valve control rod, the jacking rod can jack the valve control rod to push the valve control rod to move and extrude the valve control elastic piece, when the jacking driver drives the jacking seat to reset and continue to move away from the valve control rod, the jacking seat can extrude the reset deflector rod to move.
In one embodiment, the action part further comprises a limit guide rail connected to the shift lever base, the limit guide rail extends parallel to the limit rod, and the reset shift lever is slidably connected to the limit guide rail.
In one embodiment, the reset deflector rod is in an L-shaped structure, a first side arm of the reset deflector rod extends towards the limiting rod and is matched with the limiting rod, a second side arm of the reset deflector rod extends towards the top seat, the top seat is provided with a slope surface capable of being matched with the second side arm of the reset deflector rod, and when the top seat is driven by the jacking driver to move away from the valve control rod, the slope surface of the top seat can extrude the second side arm to push the reset deflector rod to move along the limiting guide rail.
In one embodiment, the actuating member further comprises a rolling member rotatably connected to an end of the second side arm, and the sloping surface of the top seat is capable of cooperating with the rolling member.
In one embodiment, when the shifting rod elastic piece is in a reset state, the rolling piece is in contact fit with the non-slope position of the top seat.
In one embodiment, the limiting part further comprises a matching baffle plate, the matching baffle plate is connected to the limiting rod, and the reset deflector rod can be matched with the matching baffle plate.
In one embodiment, the valve-controlled elastic member is a linear spring, and/or the position-limiting elastic member is a linear spring.
A micro-fluidic chip comprises a flow channel active valve control mechanism, wherein a valve control rod of the flow channel active valve control mechanism is movably connected to a chip supporting plate of the micro-fluidic chip to open or close a flow channel of the micro-fluidic chip, and a limiting rod is movably connected to the chip supporting plate of the micro-fluidic chip.
The flow channel active valve control mechanism can realize opening and closing states of a specific flow channel in a micro-fluidic chip which needs to do high-speed rotation movement, the valve control component and the limiting component are designed to be separated from the action component, and the electrical components are all arranged in the action component, so that the valve control component and the limiting component which do rotation movement together with the micro-fluidic chip can be miniaturized and lightened, the miniaturization of a chip supporting disk of the micro-fluidic chip is facilitated, the load of the micro-fluidic chip is reduced, in addition, the valve control component and the limiting component only have simple mechanical structures, and the reliability of the whole mechanism can be improved.
When the flow channel active valve control mechanism is in a reset state, the valve control rod is in a natural state under the action of elastic force of the valve control elastic piece, the valve control rod opens a flow channel of the microfluidic chip, at the moment, the limiting elastic piece is limited and compressed by the limiting rod, the limiting rod is abutted against the valve control rod, the limiting elastic piece is extruded by the limiting rod due to blocking of the valve control rod, the limiting elastic piece is in a compression state, at the moment, the valve control component and the limiting component are both in a separation state with the action component, and the valve control component and the limiting component can complete high-speed rotation action along with the microfluidic chip. When the runner needs to be closed, the jacking driver drives the jacking seat to move towards the direction of the valve control rod so as to drive the jacking rod to gradually contact and push the valve control rod, the valve control rod extrudes the valve control elastic piece, when the valve control rod is separated from the limiting rod, the limiting rod moves forwards under the elastic action of the limiting elastic piece, when the forward limiting rod moves to the end part of the valve control rod, the limiting rod limits the valve control rod, the valve control rod closes the runner, at the moment, the jacking driver drives the jacking seat to reset so as to drive the jacking rod to reset, although the valve control rod is not pushed by the jacking rod, the valve control rod cannot reset due to the blocking of the limiting rod, and the limiting rod keeps the valve control rod in a runner closing state. Because the jacking driver and the jacking rod are separated from the valve control rod, the valve control component and the limiting component can complete high-speed rotation along with the microfluidic chip. When the runner needs to be opened again, the valve control rod is reset, the limiting rod is located at the initial position, the limiting elastic piece is compressed, the jacking driver drives the jacking seat to move away from the valve control rod in the reverse direction, the slope surface of the jacking seat can contact with the rolling piece, when the jacking driver continues to drive the jacking seat to move away from the valve control rod in the reverse direction, the slope surface of the jacking seat can gradually push the rolling piece, the resetting shifting rod connected with the rolling piece can extrude the shifting rod elastic piece under the limiting effect of the limiting guide rail, the resetting shifting rod can shift the limiting rod and extrude the limiting elastic piece, the limiting rod gradually leaves from the end surface of the valve control rod, at the moment, the valve control rod can reset under the elastic action of the valve control elastic piece to open the runner, the jacking driver drives the jacking seat to reset, namely, the shifting rod returns to the initial position, and the resetting shifting rod resets under the.
The runner driving valve control mechanism limits the movement direction of the reset deflector rod by arranging the limiting guide rail, and the reset deflector rod reciprocates along the limiting guide rail so as to realize the shifting of the limiting rod and the self resetting.
Above-mentioned runner initiative valve control mechanism is domatic on L type structure and the footstock through setting up the driving lever that resets, and at this moment, can realize driving the jacking pole or reset the driving lever through the action of a jacking driver, and two actions of drive are realized to a driver, have further simplified mechanical structure. When the jacking driver drives the jacking seat to move away from the valve control rod, the slope surface of the jacking seat can extrude the second side arm, and due to the limiting effect of the limiting guide rail, the reset deflector rod pushes the reset deflector rod to move along the limiting guide rail, and the reset deflector rod pulls the limiting rod to move.
According to the runner driving valve control mechanism, the rolling piece is arranged, sliding friction between the slope surface of the top seat and the reset deflector rod is converted into rolling friction, friction force is reduced, and smoothness of matching between the slope surface of the top seat and the rolling piece is improved.
Above-mentioned runner initiative valve control mechanism is through setting up the cooperation baffle, and the driving lever that resets can cooperate with the cooperation baffle, and when the driving lever elastic component was compressed to the driving lever that resets, the driving lever that resets can directly touch cooperation baffle, simple structure.
Drawings
FIG. 1 is a schematic diagram of a flow channel active valve control mechanism according to an embodiment of the present invention;
FIG. 2 is a schematic view of another state of a runner active valve control mechanism according to an embodiment of the present invention;
fig. 3 is a schematic view of another state of the flow channel active valve control mechanism according to an embodiment of the present invention.
Description of the reference numerals
10. A flow passage active valve control mechanism; 100. a valve control component; 110. a valve lever; 120. valve-controlled elastic elements; 200. a limiting component; 210. a limiting rod; 220. a limiting elastic part; 230. matching with a baffle; 300. an operation member; 310. jacking up the rod; 320. a top seat; 321. a slope surface; 330. resetting the deflector rod; 331. a first side arm; 332. a second side arm; 340. a deflector rod base; 350. limiting a guide rail; 360. a rolling member; 20. chip supporting seat.
Detailed Description
In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.
In the description of the present invention, it is to be understood that the terms "central," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like are used in the orientations and positional relationships indicated in the drawings for convenience in describing the invention and to simplify the description, and are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are not to be considered limiting of the invention.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present invention, "a plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.
In the present invention, unless otherwise expressly stated or limited, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can, for example, be fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be connected internally or in any other suitable relationship, unless expressly stated otherwise. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
In the present invention, unless otherwise expressly stated or limited, the first feature "on" or "under" the second feature may be directly contacting the first and second features or indirectly contacting the first and second features through an intermediate. Also, a first feature "on," "over," and "above" a second feature may be directly or diagonally above the second feature, or may simply indicate that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.
It will be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and the like as used herein are for illustrative purposes only and do not denote a unique embodiment.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
Referring to fig. 1, an embodiment of the present invention provides a flow channel active valve control mechanism 10.
A flow channel active valve control mechanism 10 comprises a valve control component 100, a limiting component 200 and an action component 300.
The valve control block 100 has a valve stem 110 and a valve control elastic member 120. The valve stem 110 is adapted to be movably connected to a chip supporting plate of the microfluidic chip to open or close a flow channel of the microfluidic chip. The valve control elastic member 120 is connected to the valve control lever 110 to assist the valve control lever 110 in returning.
The position limiting part 200 includes a position limiting rod 210 and a position limiting elastic member 220. The limiting rod 210 is used for being movably connected to a chip supporting plate of the microfluidic chip. The stopper elastic member 220 is connected to the stopper rod 210 for driving the stopper rod 210 to move. The limiting rod 210 can move under the driving of the limiting elastic member 220 to limit the valve lever 110.
The actuating member 300 is mounted on a chip support plate of the microfluidic chip. The action member 300 is used to apply an action to the valve stem 110 to effect movement of the valve stem 110. The action component 300 is also used to apply an action to the gag lever post 210 to effect movement of the gag lever post 210.
In some embodiments, the valve stem 110 extends in a direction perpendicular to the extending direction of the stopper rod 210, and when the valve elastic member 120 is in the reset state, the stopper elastic member 220 is in the compressed state, and the stopper rod 210 abuts against the valve stem 110.
In some embodiments, the actuator 300 includes a jack-up rod 310, a top mount 320, a reset lever 330, a lever spring, a lever base 340, and a jack-up actuator. The jack-up driver is not shown in the drawings.
Referring to fig. 1, the jacking rod 310 is connected to the top base 320. The jacking driver is connected with the top seat 320 for driving the top seat 320 to move. The lifting rod 310 is disposed opposite to the valve lever 110, and the reset lever 330 is elastically and movably connected to the lever base 340 through a lever. The reset lever 330 is used for shifting the limiting rod 210 to press the limiting elastic element 220 for resetting. When the jacking actuator drives the jacking seat 320 to move toward the valve lever 110, the jacking rod 310 can jack the valve lever 110 to push the valve lever 110 to move and press the valve control elastic member 120. When the jack-up actuator drives the top seat 320 toward reset and continues to move away from the valve stem 110, the top seat 320 can depress the reset lever 330 to move.
In some embodiments, referring to fig. 1, the motion feature 300 further comprises a curb rail 350. The limit rail 350 is connected to the lever base 340. The limit rail 350 extends parallel to the limit rod 210, and the reset lever 330 is slidably coupled to the limit rail 350. The flow channel active valve control mechanism 10 limits the movement direction of the reset deflector rod 330 by arranging the limit guide rail 350, and the reset deflector rod 330 reciprocates along the limit guide rail 350, so as to realize the toggling and self-resetting of the limit rod 210.
In some embodiments, please refer to fig. 1, the reset lever 330 is an L-shaped structure. The first side arm 331 of the reset lever 330 extends toward the limiting rod 210 and is engaged with the limiting rod 210. A second side arm 332 of the reset lever 330 extends toward the top mount 320. The top seat 320 has a ramped surface 321 that is configured to engage a second side arm 332 of the reset lever 330 when the jack-up actuator drives the top seat 320 away from the valve stem 110. The ramped surface 321 of the top mount 320 can press against the second side arm 332 to push the reset lever 330 along the curb rail 350. The flow channel active valve control mechanism 10 is provided with the reset deflector rod 330 in an L-shaped structure and the slope 321 on the top seat 320, at this time, the jacking rod 310 or the reset deflector rod 330 can be driven by the action of one jacking driver, and one driver drives two actions, thereby further simplifying the mechanical structure. When the jacking driver drives the top seat 320 to move away from the valve rod 110, the slope 321 of the top seat 320 can press the second side arm 332, and due to the limiting effect of the limiting guide rail 350, the reset deflector rod 330 pushes the reset deflector rod 330 to move along the limiting guide rail 350, and the reset deflector rod 330 pulls the limiting rod 210 to move.
In some embodiments, referring to FIG. 1, the action component 300 further includes a roller 360. The rolling member 360 is rotatably coupled to the end of the second side arm 332, and the sloping surface 321 of the top seat 320 is capable of engaging with the rolling member 360. The runner active valve control mechanism 10 converts sliding friction between the slope 321 of the top seat 320 and the reset deflector rod 330 into rolling friction by arranging the rolling member 360, so that friction force is reduced, and smoothness of matching between the slope 321 of the top seat 320 and the rolling member 360 is improved.
In one particular embodiment, the rolling member 360 may be a roller.
In some embodiments, referring to fig. 1, when the toggle lever elastic element is in the reset state, the rolling element 360 is in contact with and engaged with the non-sloping surface 321 of the top seat 320.
In some embodiments, the spacing member 200 further comprises a mating baffle 230. The engaging stop 230 is connected to the limiting rod 210, and the reset lever 330 can engage with the engaging stop 230. The flow channel active valve control mechanism 10 is provided with the matching baffle 230, the reset deflector rod 330 can be matched with the matching baffle 230, and when the reset deflector rod 330 compresses the deflector rod elastic piece, the reset deflector rod 330 can directly touch the matching baffle 230, so that the structure is simple.
In some embodiments, the valve control spring 120 is a linear spring, and/or the check spring 220 is a linear spring.
The flow channel active valve control mechanism 10 can realize two states of opening and closing for a specific flow channel in a micro-fluidic chip which needs to do high-speed rotation movement, the valve control component 100 and the limiting component 200 adopt a separated design from the action component 300, and the electrical components are all arranged in the action component 300, so that the valve control component 100 and the limiting component 200 which do rotation movement together with the micro-fluidic chip can be miniaturized and lightened, a chip supporting disk of the micro-fluidic chip is miniaturized, the load of the micro-fluidic chip is reduced, in addition, the valve control component 100 and the limiting component 200 only have a simple mechanical structure, and the reliability of the whole mechanism can be improved.
When the flow channel active valve control mechanism 10 is in a reset state, please refer to fig. 1 (the bidirectional arrow in fig. 1, fig. 2, and fig. 3 indicates a moving direction), the valve control rod 110 is in a natural state under the elastic force of the valve control elastic element 120, the valve control rod 110 opens the flow channel of the microfluidic chip, at this time, the limiting rod 210 limits and compresses the limiting elastic element 220, the limiting rod 210 abuts against the valve control rod 110, due to the blocking of the valve control rod 110, the limiting rod 210 extrudes the limiting elastic element 220, the limiting elastic element 220 is in a compressed state, at this time, the valve control element 100 and the limiting element 200 are both in a separated state from the action element 300, and the valve control element 100 and the limiting element 200 can complete a high-speed rotation action along with the microfluidic chip.
When the flow channel needs to be closed, the jacking driver drives the jacking seat 320 to move towards the direction of the valve control rod 110 to drive the jacking rod 310 to gradually contact and push the valve control rod 110, the valve control rod 110 presses the valve control elastic member 120, when the valve control rod 110 is separated from the limiting rod 210, the limiting rod 210 moves forwards under the elastic force of the limiting elastic member 220, when the forwards moving limiting rod 210 moves to the end of the valve control rod 110, the limiting rod 210 limits the valve control rod 110, and the valve control rod 110 closes the flow channel, as shown in fig. 2, at this time, the jacking driver drives the jacking seat 320 to reset to drive the jacking rod 310 to reset, although the valve control rod 110 is not pushed by the jacking rod 310 any more, but the valve control rod 110 cannot reset due to the blocking of the limiting rod 210, and the limiting rod 210 keeps the valve control rod 110 in the flow channel closed state. Since the jacking driver and the jacking rod 310 are disengaged from the valve control rod 110, the valve control unit 100 and the position limiting unit 200 can complete high-speed rotation with the microfluidic chip.
When the flow channel needs to be opened again, that is, the valve control rod 110 is in a reset state, and the limiting rod 210 is in an initial position, that is, the limiting elastic element 220 is in a compressed state, the jacking driver drives the top seat 320 to move away from the valve control rod 110 in a reverse direction, the slope 321 of the top seat 320 contacts the rolling element 360, when the jacking driver continues to drive the top seat 320 to move away from the valve control rod 110 in the reverse direction, as shown in fig. 3, the slope 321 of the top seat 320 gradually pushes the rolling element 360, the reset rod 330 connected with the rolling element 360 can squeeze the rod elastic element under the limiting action of the limiting guide rail 350, the reset rod 330 can toggle the limiting rod 210 and squeeze the limiting elastic element 220, the limiting rod 210 gradually leaves from the end face of the valve control rod 110, at this time, the valve control rod 110 can reset under the elastic force of the valve control elastic element 120 to open the flow channel, the jacking driver drives the top seat 320 to reset back to the initial, the reset lever 330 is reset by the elastic force of the lever elastic member.
The embodiment of the invention also provides the micro-fluidic chip.
A micro-fluidic chip comprises the flow channel active valve control mechanism 10. The valve rod 110 of the flow channel active valve control mechanism 10 is movably connected to the chip support plate of the microfluidic chip to open or close the flow channel of the microfluidic chip, and the limiting rod 210 is movably connected to the chip support plate of the microfluidic chip.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. The flow channel active valve control mechanism is characterized by comprising a valve control component, a limiting component and an action component, wherein the valve control component is provided with a valve control rod and a valve control elastic component, the valve control rod is movably connected to a chip supporting plate of a microfluidic chip and used for opening or closing a flow channel of the microfluidic chip, and the valve control elastic component is connected with the valve control rod and used for assisting the valve control rod to reset; the limiting part comprises a limiting rod and a limiting elastic part, the limiting rod is movably connected to a chip supporting plate of the microfluidic chip, the limiting elastic part is connected with the limiting rod to drive the limiting rod to move, and the limiting rod can be driven by the limiting elastic part to move to limit the valve control rod; the action component is used for being installed on a chip supporting plate of a microfluidic chip, the action component is used for exerting action on the valve control rod to realize the movement of the valve control rod, and the action component is also used for exerting action on the limiting rod to realize the movement of the limiting rod.
2. The flow channel active valve control mechanism according to claim 1, wherein the extending direction of the valve control rod is perpendicular to the extending direction of the limiting rod, when the valve control elastic member is in the reset state, the limiting elastic member is in the compressed state, and the limiting rod abuts against the valve control rod.
3. The flow channel active valve control mechanism of claim 1, wherein the actuating component comprises a jacking rod, a top seat, a reset lifting rod, a lifting rod elastic element, a lifting rod base and a jacking actuator, the jacking rod is connected to the top seat, the jacking actuator is connected to the top seat for driving the top seat to move, the jacking rod is arranged opposite to the valve control rod, the reset lifting rod is movably connected to the lifting rod base through the lifting rod elastic element, the reset lifting rod is used for pushing the limiting rod to press the limiting elastic element for resetting, when the jacking actuator drives the top seat to move towards the valve control rod, the jacking rod can press the valve control rod to push the valve control rod to move and press the valve control elastic element, when the jacking actuator drives the top seat to reset towards and continue to move away from the valve control rod, the footstock can extrude the reset deflector rod to move.
4. The runner active valve mechanism of claim 3, wherein the actuation member further comprises a limit rail connected to the stem base, the limit rail extending parallel to the limit post, the reset stem being slidably connected to the limit rail.
5. The runner active valve control mechanism of claim 4, wherein the reset lever is of an L-shaped configuration, a first side arm of the reset lever extends toward and engages the limit rod, a second side arm of the reset lever extends toward the top seat, and the top seat has a slope that can engage the second side arm of the reset lever, and the slope of the top seat can press the second side arm to push the reset lever to move along the limit rail when the jack-up actuator drives the top seat to move away from the valve rod.
6. The runner driving valve control mechanism of claim 5, wherein the actuating member further comprises a roller rotatably connected to an end of the second side arm, and the ramp surface of the top seat is capable of engaging with the roller.
7. The runner active valve mechanism of claim 6, wherein the roller is in contact engagement with the non-ramped surface of the top seat when the toggle lever elastomer is in the reset state.
8. The runner driving valve control mechanism of claim 5, wherein the position limiting component further comprises a fitting baffle connected to the position limiting rod, and the reset deflector rod is capable of fitting with the fitting baffle.
9. The flow channel active valve control mechanism according to any one of claims 1-7, wherein the valve control elastic member is a linear spring, and/or the limit elastic member is a linear spring.
10. A microfluidic chip, comprising the flow channel active valve control mechanism of any one of claims 1 to 9, wherein the valve control rod of the flow channel active valve control mechanism is movably connected to a chip support plate of the microfluidic chip to open or close a flow channel of the microfluidic chip, and the limit rod is movably connected to the chip support plate of the microfluidic chip.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110469648.3A CN112973818A (en) | 2021-04-28 | 2021-04-28 | Flow channel active valve control mechanism and micro-fluidic chip |
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| CN202110469648.3A CN112973818A (en) | 2021-04-28 | 2021-04-28 | Flow channel active valve control mechanism and micro-fluidic chip |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115025827A (en) * | 2022-07-01 | 2022-09-09 | 苏州思迈德生物科技有限公司 | Micro-valve driving device and micro-fluidic chip |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115025827A (en) * | 2022-07-01 | 2022-09-09 | 苏州思迈德生物科技有限公司 | Micro-valve driving device and micro-fluidic chip |
| CN115025827B (en) * | 2022-07-01 | 2023-11-21 | 苏州思迈德生物科技有限公司 | Micro-valve driving device and micro-fluidic chip |
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