CN112972060A - Device for preventing tissue adhesion in operation area after craniotomy in neurosurgery - Google Patents
Device for preventing tissue adhesion in operation area after craniotomy in neurosurgery Download PDFInfo
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- CN112972060A CN112972060A CN202110154492.XA CN202110154492A CN112972060A CN 112972060 A CN112972060 A CN 112972060A CN 202110154492 A CN202110154492 A CN 202110154492A CN 112972060 A CN112972060 A CN 112972060A
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- lock catch
- operation area
- dura mater
- craniotomy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
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Abstract
The invention discloses a device for preventing tissue adhesion in an operation area after a craniotomy in neurosurgery, which comprises a subdural device positioned at the inner side of a dura mater and a epidural device positioned at the outer side of the dura mater; the subdural device consists of a concave lock catch layer, an artificial meninges, a super-hydrophilic coating and an antibiotic coating; the epidural device consists of a convex lock catch layer, an artificial meninges, a super-hydrophilic coating and an antibiotic coating; the invention fixes the endocranium with a concave, convex or concave-convex combined structure, thus repairing potential fistula on the endocranium and reducing the risk of cerebrospinal fistula after operation; the norvancomycin-loaded drug-loaded slow-release layer is fixed on the outermost layer of the membrane, the slow-release characteristic of the membrane is utilized, so that the antibiotic in an operation area is kept at an effective concentration within 72 hours after operation, the risk of infection in the operation area is reduced, and meanwhile, the super-hydrophilic coating exposed after the slow release of the drug-loaded layer is finished plays a role in preventing tissue adhesion sequentially.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a device for preventing tissue adhesion in an operation area after a craniotomy in neurosurgery.
Background
Scar adhesion of dura mater and surrounding tissues after craniotomy is a common complication of neurosurgery and has attracted more and more attention of neurosurgeons. Research shows that the adhesion of the dura mater and the cortex scar after craniocerebral operation is one of the risk factors for postoperative epilepsy. Meanwhile, aiming at common planned secondary operations (skull defect repairing operations after craniocerebral trauma and bone flap removal and pressure reduction and operative region recurrent focus resection of tumors) of neurosurgery, the anatomy caused by the structural adhesion of tissues in operative regions is unclear, so that the increase of craniotomy bleeding amount, the prolongation of operative time and the increase of operation difficulty are caused.
At present, with the understanding of the mechanism of the generation of the scar adhesion of the dura mater and the development of materials, more and more preventive measures are applied to clinic, such as treated autologous tissues (autologous fat tablets, small intestine mucosa, autologous bone plates and the like), polymeric materials of high molecular substances (postoperative anti-adhesion electrostatic spinning membranes). However, no evidence of evidence-based medicine proves the effectiveness of the current adhesion prevention measures, and reports aiming at the infection of the operation area and the cerebrospinal fistula caused by the implant are frequent.
In summary, the following problems exist in the prior art:
(1) the existing measures for preventing adhesion after neurosurgery operation do not have the functions of diminishing inflammation and sterilizing, and on the contrary, the existence of foreign matters increases the risk of infection in the operation area.
(2) The existing measures for preventing adhesion after neurosurgery operation do not have the function of repairing the potential fistula of dura mater and can not reduce the occurrence of cerebrospinal fistula after the operation.
(3) The existing measures for preventing adhesion after neurosurgery are usually only aimed at physical isolation between dura mater and brain parenchyma, but neglect the isolation between dura mater and cap aponeurosis after the bone flap removing and pressure reducing operation, and cause serious adhesion during skull defect repairing operation.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention provides a device for preventing tissue adhesion in an operation area after a craniotomy in neurosurgery, which has the functions of reducing scar adhesion in the operation area, defining an anatomical structure in the operation area and preventing cerebrospinal fluid fistula.
In order to solve the technical problems, the invention provides the following technical scheme:
a device for preventing tissue adhesion of an operation area after a craniotomy in neurosurgery is characterized by comprising a subdural device positioned at the inner side of a dura mater and an epidural device positioned at the outer side of the dura mater; the subdural device consists of a concave lock catch layer, an artificial meninges, a super-hydrophilic coating and an antibiotic coating; the epidural device consists of a convex lock catch layer, an artificial meninges, a super-hydrophilic coating and an antibiotic coating.
As a preferred technical scheme of the invention, one surface of the concave lock catch layer with the concave lock catch is adjacent to the inner layer of the dura mater and is fixedly connected with the dura mater through a ligature, and the other surface of the concave lock catch layer is adjacent to the artificial dura mater and is fixed by glue;
as a preferable technical scheme of the invention, one side of the convex lock catch layer with the convex lock catch is adjacent to the dura mater outer layer and is fixedly connected with the dura mater through a ligature, and the other side of the convex lock catch layer is adjacent to the artificial dura mater and is fixed by glue.
As a preferred technical scheme of the invention, the artificial meninges is made of expanded polytetrafluoroethylene high-molecular polymer materials, one surface of the artificial meninges is fixed with the lock catch layer by glue, and the other surface of the artificial meninges is coated with the super-hydrophilic coating.
As a preferable technical scheme of the invention, the super-hydrophilic coating is made of a BR type hydrophilic lubricating coating and is coated on the artificial meninges.
As a preferred technical scheme of the invention, the antibiotic coating is made of three layers of norvancomycin drug-loaded membranes and is coated on the super-hydrophilic coating.
In a preferred embodiment of the present invention, the ligature is a non-absorbable suture.
Compared with the prior art, the invention can achieve the following beneficial effects:
(1) the invention consists of a subdural device and an epidural device, and is suitable for the requirement of pre-adhesion prevention after craniotomy of all neurosurgery.
(2) The invention utilizes the concave, convex or concave-convex combined structure to fix the invention with the dura mater, thereby repairing the potential fistula on the dura mater and reducing the risk of cerebrospinal fluid fistula after operation.
(3) The norvancomycin-loaded drug-loaded slow-release layer is fixed on the outermost layer of the membrane, and the slow-release characteristic of the membrane is utilized to keep the effective concentration of the antibiotic in the operation area within 72 hours after operation, so that the risk of infection in the operation area is reduced. Meanwhile, the super-hydrophilic coating exposed after the slow release of the drug-loaded layer plays a role in preventing tissue adhesion sequentially.
(4) The invention utilizes the sequentially exposed BR-type super-hydrophilic coating to play a role in preventing tissue adhesion in an operation area. The medical-grade water-soluble biological macromolecule is organically combined to the surface of the artificial meninges through a coupling agent. One end of the coupling agent is combined with the hydrophobic group on the surface of the artificial meninges, and the other end is combined with the water-soluble biological polymer. After the antibiotic slow-release coating is ablated, the super-hydrophilic coating is contacted with cerebrospinal fluid or interstitial fluid, and the hydrophilic group of the water-soluble biopolymer is combined with water and rapidly swells to form a biological membrane similar to the surface of loach, so that the coating has an excellent hydrophilic lubricating effect and effectively avoids the adhesion of an operative area.
Drawings
FIG. 1 is a schematic view showing the overall structure of the device for preventing tissue adhesion in an operation area after a neurosurgical craniotomy (slow-release antibiotic state, bone flap removing state) in the working state;
FIG. 2 is a schematic view showing the overall structure of the device for preventing tissue adhesion in the operation area after a neurosurgical craniotomy (slow-release antibiotic, non-flap-removed state) according to the invention;
FIG. 3 is a schematic view of the general structure of the device for preventing tissue adhesion in the operation area after the neurosurgical craniotomy of the invention (antibiotic release completion state);
wherein: 1. the dura mater; 2. a male locking layer; 3. an antibiotic coating; 4. a super-hydrophilic coating; 5. artificial meninges; 6. a concave locking layer; 7. and (6) tying the wires.
Detailed Description
The preferred embodiments of the present invention will be described in conjunction with the accompanying drawings, and it will be understood that they are described herein for the purpose of illustration and explanation and not limitation.
Referring to the attached drawing I, the general working state structure (slow release antibiotic state, bone flap removing state) of the device for preventing tissue adhesion in the operation area after the craniotomy of neurosurgery of the invention is shown schematically. This state can be applied to a flap-removed decompression state, enabling subdural and epidural devices. This state is within 72 hours of the operation, with slow release of the antibiotic.
Referring to the attached drawing II, the general working state structure (slow release antibiotic, non-flap-removed state) of the device for preventing tissue adhesion in the operation area after the craniotomy of neurosurgery of the invention is shown schematically. This state can be applied to an un-debulked decompression state, enabling the subdural device. This state is within 72 hours of the operation, with slow release of the antibiotic.
Referring to the attached figure III, the overall structure diagram of the device for preventing the tissue adhesion of the operation area after the craniotomy in the neurosurgery of the invention is in the working state of the slow release ending state of the antibiotics. This state can be applied to a flap-removed decompression state, enabling subdural and epidural devices. After 72 hours after the operation, the slow release of the antibiotic is finished, and the super-hydrophilic coating is exposed to play a role in preventing adhesion.
The invention consists of a subdural device and an epidural device, and is suitable for the requirement of pre-adhesion prevention after craniotomy of all neurosurgery.
The invention utilizes the concave, convex or concave-convex combined structure to fix the invention with the dura mater, thereby repairing the potential fistula on the dura mater and reducing the risk of cerebrospinal fluid fistula after operation.
The norvancomycin-loaded drug-loaded slow-release layer is fixed on the outermost layer of the membrane, and the slow-release characteristic of the membrane is utilized to keep the effective concentration of the antibiotic in the operation area within 72 hours after operation, so that the risk of infection in the operation area is reduced. Meanwhile, the super-hydrophilic coating exposed after the slow release of the drug-loaded layer plays a role in preventing tissue adhesion sequentially.
The invention utilizes the sequentially exposed BR-type super-hydrophilic coating to play a role in preventing tissue adhesion in an operation area. The medical-grade water-soluble biological macromolecule is organically combined to the surface of the artificial meninges through a coupling agent. One end of the coupling agent is combined with the hydrophobic group on the surface of the artificial meninges, and the other end is combined with the water-soluble biological polymer. After the antibiotic slow-release coating is ablated, the super-hydrophilic coating is contacted with cerebrospinal fluid or interstitial fluid, and the hydrophilic group of the water-soluble biopolymer is combined with water and rapidly swells to form a biological membrane similar to the surface of loach, so that the coating has an excellent hydrophilic lubricating effect and effectively avoids the adhesion of an operative area.
The embodiments of the present invention are not limited thereto, and according to the above-described embodiments of the present invention, other embodiments obtained by modifying, replacing or combining the above-described preferred embodiments in various other forms without departing from the basic technical idea of the present invention by using the conventional technical knowledge and the conventional means in the field can fall within the scope of the present invention.
Claims (7)
1. A device for preventing tissue adhesion of an operation area after a craniotomy in neurosurgery is characterized by comprising a subdural device positioned at the inner side of a dura mater (1) and an epidural device positioned at the outer side of the dura mater (1); the subdural device consists of a concave lock catch layer (6), an artificial meninges (5), a super-hydrophilic coating (4) and an antibiotic coating (3); the epidural device consists of a convex lock catch layer (2), an artificial meninges (5), a super-hydrophilic coating (4) and an antibiotic coating (3).
2. The device for preventing tissue adhesion of an operation area after a neurosurgical craniotomy, according to claim 1, wherein the concave lock catch layer (6) is provided with a concave lock catch, one surface of the concave lock catch is adjacent to the inner layer of the dura mater (1) and is fixedly connected with the dura mater (1) through a ligature (7), and the other surface of the concave lock catch is adjacent to the artificial dura mater (5) and is fixed by glue.
3. The device for preventing tissue adhesion of an operation area after a neurosurgical craniotomy, according to claim 1, wherein the convex lock catch layer (2) is provided with a convex lock catch, one surface of the convex lock catch is adjacent to the outer layer of the dura mater (1) and is fixedly connected with the dura mater (1) through a ligature (7), and the other surface of the convex lock catch is adjacent to the artificial dura mater (5) and is fixed by glue.
4. The device for preventing the tissue adhesion of the operation area after the craniotomy in the neurosurgery is characterized in that the artificial meninges (5) are made of expanded polytetrafluoroethylene high polymer materials, one surface of the artificial meninges (5) is fixed with the lock catch layer by glue, and the other surface of the artificial meninges is coated with the super-hydrophilic coating (4).
5. The device for preventing tissue adhesion of operative area after craniotomy of neurosurgery according to claim 1, wherein the super-hydrophilic coating (4) is made of a hydrophilic lubricating coating of BR type, applied to the artificial meninges (5).
6. The device for preventing tissue adhesion of operation area after craniotomy of neurosurgery according to claim 1, wherein the antibiotic coating (3) is made of three layers of norvancomycin drug-loaded membrane coated on the super-hydrophilic coating (4).
7. A device for preventing tissue adhesion in the operative field after a neurosurgical craniotomy, according to claim 2 or 3, wherein the ligature (7) is a non-absorbable suture.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110154492.XA CN112972060B (en) | 2021-02-04 | 2021-02-04 | Device for preventing operation area from blocking after craniotomy in neurosurgery |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110154492.XA CN112972060B (en) | 2021-02-04 | 2021-02-04 | Device for preventing operation area from blocking after craniotomy in neurosurgery |
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| CN112972060A true CN112972060A (en) | 2021-06-18 |
| CN112972060B CN112972060B (en) | 2023-07-14 |
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Citations (10)
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| JP2003199817A (en) * | 2001-11-01 | 2003-07-15 | Kawasumi Lab Inc | Artificial dura mater |
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| CN106510896A (en) * | 2016-12-06 | 2017-03-22 | 王晓松 | Artificial cerebral dura mater |
| CN209092278U (en) * | 2018-07-27 | 2019-07-12 | 陕西佰傲再生医学有限公司 | A kind of compound antibacterial biological dural patch |
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2021
- 2021-02-04 CN CN202110154492.XA patent/CN112972060B/en active Active
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2201163C1 (en) * | 2001-08-16 | 2003-03-27 | Кемеровская городская клиническая больница № 3 им. М.А. Подгорбунского | Method for substituting dura mater defect |
| JP2003199817A (en) * | 2001-11-01 | 2003-07-15 | Kawasumi Lab Inc | Artificial dura mater |
| CN1830492A (en) * | 2006-03-20 | 2006-09-13 | 刘佰运 | Bioprotein artificial meninges sheet |
| CN101507661A (en) * | 2009-03-10 | 2009-08-19 | 广州迈普再生医学科技有限公司 | Nano artificial dura mater with multi functional-layers and preparation method thereof |
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| US20120029654A1 (en) * | 2009-03-10 | 2012-02-02 | Medprin Regenerative Medical Technologies Co., Ltd. | Artificial dura mater and manufacturing method thereof |
| CN101559242A (en) * | 2009-05-22 | 2009-10-21 | 广州迈普再生医学科技有限公司 | Nano artificial dura mater capable of being used as medicine sustained-release system and preparation method thereof |
| CN103418031A (en) * | 2012-05-17 | 2013-12-04 | 天津市康尔医疗器械有限公司 | Absorbable endocranium healing patch and preparation method thereof |
| CN106510896A (en) * | 2016-12-06 | 2017-03-22 | 王晓松 | Artificial cerebral dura mater |
| CN209092278U (en) * | 2018-07-27 | 2019-07-12 | 陕西佰傲再生医学有限公司 | A kind of compound antibacterial biological dural patch |
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| CN112972060B (en) | 2023-07-14 |
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