CN112957500A - Hydrogen peroxide steam large-system disinfection system for high-grade biosafety laboratory - Google Patents
Hydrogen peroxide steam large-system disinfection system for high-grade biosafety laboratory Download PDFInfo
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- CN112957500A CN112957500A CN202110358904.1A CN202110358904A CN112957500A CN 112957500 A CN112957500 A CN 112957500A CN 202110358904 A CN202110358904 A CN 202110358904A CN 112957500 A CN112957500 A CN 112957500A
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- air supply
- exhaust
- hydrogen peroxide
- air
- pipe
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- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 title claims abstract description 75
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 36
- 230000001954 sterilising effect Effects 0.000 claims description 9
- 230000001681 protective effect Effects 0.000 claims description 7
- 241000282693 Cercopithecidae Species 0.000 claims description 6
- 238000002955 isolation Methods 0.000 claims description 6
- 230000007170 pathology Effects 0.000 claims description 6
- 238000005070 sampling Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 abstract description 4
- 244000000010 microbial pathogen Species 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 238000004378 air conditioning Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000011229 interlayer Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/20—Gaseous substances, e.g. vapours
- A61L2/208—Hydrogen peroxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L9/00—Disinfection, sterilisation or deodorisation of air
- A61L9/015—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2209/00—Aspects relating to disinfection, sterilisation or deodorisation of air
- A61L2209/20—Method-related aspects
- A61L2209/21—Use of chemical compounds for treating air or the like
- A61L2209/211—Use of hydrogen peroxide, liquid and vaporous
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention discloses a hydrogen peroxide steam large-system disinfection system for a high-grade biosafety laboratory, which comprises an air supply system, an air exhaust system, the high-grade biosafety laboratory and a hydrogen peroxide steam generator, wherein the hydrogen peroxide steam generator is connected with the high-grade biosafety laboratory; the high-grade biological safety laboratory comprises a plurality of room chambers; the air supply system comprises an air supply main valve and an air supply branch pipe; the exhaust system comprises an exhaust fan set, an exhaust main valve and a plurality of exhaust branch pipes; an air supply branch pipe and an air exhaust branch pipe are respectively communicated with each room cavity; each air supply branch pipe is provided with an air supply high-efficiency filter unit, and each air exhaust branch pipe is provided with an air exhaust high-efficiency filter unit; a bypass pipe is connected between the air supply main valve and the air exhaust main valve, and a bypass valve is arranged on the bypass pipe; the hydrogen peroxide vapor generator is disposed within the room chamber. The large system disinfection system has the advantages of sufficient disinfection, safety, reliability, high efficiency of the disinfection process and low overall disinfection cost.
Description
Technical Field
The invention relates to the technical field of high-grade biosafety laboratory disinfection, in particular to a hydrogen peroxide steam large-system disinfection system for a high-grade biosafety laboratory.
Background
A high-grade biosafety laboratory is a laboratory (factory building) with the protection level of three-grade (danger level 2 microorganism) and four-grade (danger level 1 microorganism), and is mainly used for relevant work such as separation culture, diagnosis, identification, research and the like of highly pathogenic microorganisms and vaccine production.
Whether the laboratory biosafety is important or not is judged, and the reliable disinfection and sterilization mode can effectively kill pathogenic microorganisms, cut off the propagation path and guarantee the laboratory biosafety.
The method is characterized in that a laboratory system (a system consisting of a room, a biological safety cabinet, an IVC, a pathology sampling table, a monkey negative pressure isolation cabinet and other key protection equipment high-efficiency filters, a high-efficiency filtering unit, an air feeding and exhausting high-efficiency filter and a pipeline in an independent air conditioning system) is thoroughly disinfected according to each specified experimental period or annual inspection, and the system part is disinfected independently, so that the method has the advantages of multiple objects, wide range, high difficulty, multiple required disinfection equipment, long time consumption and low disinfection efficiency. .
Disclosure of Invention
The invention aims to provide a large hydrogen peroxide steam system disinfection system for a high-grade biosafety laboratory, which has the advantages of good disinfection effect, safety, reliability, high efficiency, manpower and material resource saving and low overall disinfection cost.
In order to solve the technical problems, the technical scheme of the invention is as follows:
a hydrogen peroxide steam large system disinfection system for a high-grade biosafety laboratory comprises an air supply system, an air exhaust system, the high-grade biosafety laboratory and a hydrogen peroxide steam generator; the high-grade biological safety laboratory comprises a plurality of room chambers; one or more of a biological safety cabinet, an IVC (integrated medical control), a pathology sampling table and a monkey negative pressure isolation cabinet are arranged in the room cavity; the air supply system comprises an air supply fan set, an air supply main valve, an air supply main pipe and a plurality of air supply branch pipes, wherein the air supply main pipe is sequentially provided with the air supply fan set and the air supply main valve, and the air supply main pipe positioned at the rear side of the air supply main valve is connected with the plurality of air supply branch pipes; the exhaust system comprises an exhaust fan set, an exhaust main valve, an exhaust main pipe and a plurality of exhaust branch pipes, wherein the exhaust main pipe is sequentially provided with the exhaust fan set and the exhaust main valve, and the exhaust main pipe positioned on the front side of the exhaust fan set is connected with the plurality of exhaust branch pipes; an air supply branch pipe and an air exhaust branch pipe are respectively communicated with each room cavity; each air supply branch pipe is provided with an air supply high-efficiency filter unit, and each air exhaust branch pipe is provided with an air exhaust high-efficiency filter unit; a bypass pipe is connected between the air supply main valve and the air exhaust main valve, and a bypass valve is arranged on the bypass pipe; the hydrogen peroxide vapor generator is disposed within the room chamber.
Preferably, the hydrogen peroxide vapor generator is arranged in two or more stages.
Preferably, a second air exhaust high-efficiency filter unit is arranged on the air exhaust main pipe.
Preferably, the room chambers include shower rooms, more protective clothing rooms, buffer rooms, core laboratories, and seed holding rooms.
The invention has the beneficial effects that:
(1) the invention is simple and convenient to operate, when in use, the main air supply valve and the main air exhaust valve are firstly closed, and the bypass valve arranged on the bypass pipe is opened, so that a relatively closed circulating system is formed among the hydrogen peroxide steam generator, the branch air exhaust pipe, the air exhaust fan set, the branch air supply pipe and the room cavity; normally starting up the critical protection equipment (such as a biological safety cabinet, an IVC, a pathology sampling table and a monkey negative pressure isolation cabinet) in the experiment for operation during disinfection; the hydrogen peroxide steam generator generates hydrogen peroxide steam, one part of the hydrogen peroxide steam enters the protective equipment through a fan arranged on the key protective equipment in a room and enters the exhaust system after passing through a high-efficiency filter arranged on the equipment, and the other part of the hydrogen peroxide steam provides power for gas circulation through the exhaust fan set, penetrates through the exhaust high-efficiency filter of the air conditioning system and then passes through the air supply pipeline and the air supply high-efficiency filter and then enters the room, so that the hydrogen peroxide steam is circularly sterilized.
(2) Hydrogen Peroxide Vapor (HPV), an advanced high-level green disinfection technology, acts on the principle of dissociating highly active hydroxyl groups through complex chemical reactions to destroy cell membranes, lipids, proteins and DNA. The hydrogen peroxide vapor has broad-spectrum bactericidal effect on bacteria, fungi, viruses and other microorganisms.
(3) When the disinfection system is used for disinfection, the air exhaust fan set provides power, the disinfection system is in a negative pressure state, so that the risk of leakage of pathogenic microorganisms is reduced, safety and reliability are realized, and the air supply pipe and the air exhaust pipe are disinfected together in the disinfection process, so that the whole disinfection is more sufficient.
(4) When the room and the equipment of high-grade biosafety laboratory are disinfected separately in the tradition, the required quantity of disinfection equipment, disinfection times and the manpower invested in disinfection are all more. The high-grade biological safety laboratory is disinfected by the disinfection device, the laboratory protection area is divided into 10 rooms, the efficient filter unit, the safety cabinet and other key protection devices 21 sets, the devices are dispersed in the interlayer and the rooms, each room or each device needs to be disinfected independently at least 4 h/time, and the whole laboratory needs to be disinfected for more than 20 days; the room and the equipment are independently sterilized, the number of required sterilizing equipment is large, the sterilizing frequency is more than 31, 3 persons are required each time, and about 63 persons are required to be invested. However, the large system of the invention can be used for 4-6 people to sterilize for 1 time, so that the sterilization task of the whole laboratory can be completed, and the manpower and material resources are greatly saved.
Drawings
FIG. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a schematic view of the structure of the blowing system of the present invention;
fig. 3 is a schematic view of the structure of the exhaust system of the present invention.
In the figure, 1-air supply system, 2-air exhaust system, 3-high-grade biosafety laboratory, 4-hydrogen peroxide vapor generator, 5-by-pass pipe, 6-by-pass valve, 10-air supply fan set, 11-air supply main valve, 12-air supply main pipe, 13-air supply branch pipe, 14-air supply high-efficiency filter unit, 20-air exhaust fan set, 21-air exhaust main valve, 22-air exhaust main pipe, 23-air exhaust branch pipe, 24-air exhaust high-efficiency filter unit, 25-second air exhaust high-efficiency filter unit and 30-room chamber.
Detailed Description
The following further describes embodiments of the present invention with reference to the drawings. It should be noted that the description of the embodiments is provided to help understanding of the present invention, but the present invention is not limited thereto. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
As shown in fig. 1-3, a hydrogen peroxide steam major system disinfection system for a high-grade biosafety laboratory comprises an air supply system 1, an air exhaust system 2, a high-grade biosafety laboratory 3 and a hydrogen peroxide steam generator 4; the high-grade biosafety laboratory 3 comprises a plurality of room chambers 30; one or more of a biological safety cabinet, an IVC (integrated medical science) cabinet, a pathology sampling table and a monkey negative pressure isolation cabinet are arranged in the room chamber 30; the air supply system 1 comprises an air supply fan set 10, an air supply main valve 11, an air supply main pipe 12 and a plurality of air supply branch pipes 13, wherein the air supply main pipe 12 is sequentially provided with the air supply fan set 10 and the air supply main valve 11, and the air supply main pipe 12 positioned at the rear side of the air supply main valve 11 is connected with the air supply branch pipes 13; the exhaust system 2 comprises an exhaust fan group 20, an exhaust main valve 21, an exhaust main pipe 22 and a plurality of exhaust branch pipes 23, the exhaust main pipe 22 is sequentially provided with the exhaust fan group 20 and the exhaust main valve 21, and the exhaust main pipe 22 positioned at the front side of the exhaust fan group 20 is connected with the plurality of exhaust branch pipes 23; an air supply branch pipe 13 and an air exhaust branch pipe 23 are respectively communicated with each room chamber 30; an air supply high-efficiency filter unit 14 is arranged on each air supply branch pipe 13, and an air exhaust high-efficiency filter unit 24 is arranged on each air exhaust branch pipe 23; a bypass pipe 5 is connected between the air supply main valve 11 and the air exhaust main valve 21, and a bypass valve 6 is arranged on the bypass pipe 5; the hydrogen peroxide vapor generator 4 is disposed within the room chamber 30.
Preferably, in order to facilitate better distribution of the hydrogen peroxide vapor and improve the sterilization effect, more than two hydrogen peroxide vapor generators 4 are arranged.
Preferably, a second air-exhausting high-efficiency filter unit 25 is arranged on the air exhaust main pipe 22. By the arrangement of the two-stage exhaust high-efficiency filter unit 25, the circulating air flow can be better filtered.
Preferably, the room chambers 30 include shower rooms, more protective clothing rooms, buffer rooms, core laboratories, and seed holding rooms.
The working principle of the invention is as follows:
the invention utilizes the air supply and exhaust system of the existing high-grade biosafety laboratory, the whole air supply and exhaust system is communicated by additionally arranging the bypass pipe 5 and the bypass valve 6, and meanwhile, a relatively closed circulating system is formed among the exhaust branch pipe 23, the exhaust fan set 20, the air supply branch pipe 13 and the room chamber 30 by controlling the air supply main valve 11, the exhaust main valve 21 and the bypass valve 6, and then, the critical protection equipment (such as a biosafety cabinet, an IVC, a pathology sampling table and a monkey negative pressure isolation cabinet) in the experiment is normally started to operate during disinfection; the hydrogen peroxide steam generator 4 generates hydrogen peroxide steam, one part of the hydrogen peroxide steam enters the protective equipment through a fan arranged on the key protective equipment in a room, and enters an exhaust system after passing through a high-efficiency filter arranged on the equipment, and the other part of the hydrogen peroxide steam provides power of gas circulation through an exhaust fan set 20, penetrates through an exhaust high-efficiency filter unit 24, then passes through an air supply pipeline and an air supply high-efficiency filter unit 14, and enters the room, so that the hydrogen peroxide steam is disinfected circularly.
The embodiments of the present invention have been described in detail with reference to the accompanying drawings, but the present invention is not limited to the described embodiments. It will be apparent to those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, and the scope of protection is still within the scope of the invention.
Claims (4)
1. A hydrogen peroxide vapor macrosystem sterilization system for high-grade biosafety laboratories, characterized in that: comprises an air supply system (1), an air exhaust system (2), a high-grade biosafety laboratory (3) and a hydrogen peroxide steam generator (4); the high-grade biosafety laboratory (3) comprises a plurality of room chambers (30); one or more of a biological safety cabinet, an IVC (integrated medical science) cabinet, a pathology sampling table and a monkey negative pressure isolation cabinet are arranged in the room chamber (30); the air supply system (1) comprises an air supply fan set (10), an air supply main valve (11), an air supply main pipe (12) and a plurality of air supply branch pipes (13), wherein the air supply main pipe (12) is sequentially provided with the air supply fan set (10) and the air supply main valve (11), and the air supply main pipe (12) positioned at the rear side of the air supply main valve (11) is connected with the air supply branch pipes (13); the exhaust system (2) comprises an exhaust fan set (20), an exhaust main valve (21), an exhaust main pipe (22) and a plurality of exhaust branch pipes (23), wherein the exhaust main pipe (22) is sequentially provided with the exhaust fan set (20) and the exhaust main valve (21), and the exhaust main pipe (22) positioned on the front side of the exhaust fan set (20) is connected with the plurality of exhaust branch pipes (23); an air supply branch pipe (13) and an air exhaust branch pipe (23) are respectively communicated with each room chamber (30); an air supply high-efficiency filter unit (14) is arranged on each air supply branch pipe (13), and an air exhaust high-efficiency filter unit (24) is arranged on each air exhaust branch pipe (23); a bypass pipe (5) is connected between the air supply main valve (11) and the air exhaust main valve (21), and a bypass valve (6) is arranged on the bypass pipe (5); the hydrogen peroxide vapor generator (4) is arranged within the room chamber (30).
2. A hydrogen peroxide vapor macrosystem sterilization system for high-grade biosafety laboratories according to claim 1, characterized in that: more than two hydrogen peroxide steam generators (4) are arranged.
3. A hydrogen peroxide vapor macrosystem sterilization system for high-grade biosafety laboratories according to claim 1, characterized in that: and a second air exhaust high-efficiency filter unit (25) is arranged on the air exhaust main pipe (22).
4. A hydrogen peroxide vapor macrosystem sterilization system for high-grade biosafety laboratories according to any one of claims 1 to 3, characterized in that: the room chambers (30) include shower rooms, more protective clothing rooms, buffer rooms, core laboratories, and seed containment rooms.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110358904.1A CN112957500A (en) | 2021-04-02 | 2021-04-02 | Hydrogen peroxide steam large-system disinfection system for high-grade biosafety laboratory |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110358904.1A CN112957500A (en) | 2021-04-02 | 2021-04-02 | Hydrogen peroxide steam large-system disinfection system for high-grade biosafety laboratory |
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| Publication Number | Publication Date |
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| CN112957500A true CN112957500A (en) | 2021-06-15 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110358904.1A Pending CN112957500A (en) | 2021-04-02 | 2021-04-02 | Hydrogen peroxide steam large-system disinfection system for high-grade biosafety laboratory |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114028595A (en) * | 2021-10-28 | 2022-02-11 | 武汉生物制品研究所有限责任公司 | Novel coronavirus aerosol exposure system disinfection and evaluation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08200736A (en) * | 1995-01-26 | 1996-08-06 | Taikisha Ltd | Air conditioning sterilizing and deodorizing apparatus |
| CN108079349A (en) * | 2017-12-26 | 2018-05-29 | 浙江泰林生物技术股份有限公司 | A kind of large area plants sterilization and disinfection device |
| CN207880986U (en) * | 2018-02-02 | 2018-09-18 | 上海沪试实验室器材股份有限公司 | A kind of automation ozone disinfection system for biocontainment laboratory |
| CN209108194U (en) * | 2018-07-06 | 2019-07-16 | 上海继伟制药设备有限公司 | A kind of VHP sterilizer |
| CN110043999A (en) * | 2019-04-24 | 2019-07-23 | 中国科学院武汉病毒研究所 | A kind of biosecurity laboratory exhaust system and negative pressure keeping method and circulation sterilization method |
| CN216022270U (en) * | 2021-04-02 | 2022-03-15 | 中国医学科学院医学生物学研究所 | A disinfection system for high-grade biosafety laboratory |
-
2021
- 2021-04-02 CN CN202110358904.1A patent/CN112957500A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08200736A (en) * | 1995-01-26 | 1996-08-06 | Taikisha Ltd | Air conditioning sterilizing and deodorizing apparatus |
| CN108079349A (en) * | 2017-12-26 | 2018-05-29 | 浙江泰林生物技术股份有限公司 | A kind of large area plants sterilization and disinfection device |
| CN207880986U (en) * | 2018-02-02 | 2018-09-18 | 上海沪试实验室器材股份有限公司 | A kind of automation ozone disinfection system for biocontainment laboratory |
| CN209108194U (en) * | 2018-07-06 | 2019-07-16 | 上海继伟制药设备有限公司 | A kind of VHP sterilizer |
| CN110043999A (en) * | 2019-04-24 | 2019-07-23 | 中国科学院武汉病毒研究所 | A kind of biosecurity laboratory exhaust system and negative pressure keeping method and circulation sterilization method |
| CN216022270U (en) * | 2021-04-02 | 2022-03-15 | 中国医学科学院医学生物学研究所 | A disinfection system for high-grade biosafety laboratory |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114028595A (en) * | 2021-10-28 | 2022-02-11 | 武汉生物制品研究所有限责任公司 | Novel coronavirus aerosol exposure system disinfection and evaluation method |
| CN114028595B (en) * | 2021-10-28 | 2023-09-19 | 武汉生物制品研究所有限责任公司 | Novel disinfection and evaluation method for coronavirus aerosol exposure system |
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Application publication date: 20210615 |
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