CN112957013B - Dynamic vital sign signal acquisition system, monitoring device and equipment - Google Patents

Dynamic vital sign signal acquisition system, monitoring device and equipment Download PDF

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CN112957013B
CN112957013B CN202110164206.8A CN202110164206A CN112957013B CN 112957013 B CN112957013 B CN 112957013B CN 202110164206 A CN202110164206 A CN 202110164206A CN 112957013 B CN112957013 B CN 112957013B
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vital sign
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sign signal
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CN112957013A (en
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陈文强
刘绪平
蔡超
王绎
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Jiangxi Guoke Meixin Medical Technology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • A61B5/7207Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise induced by motion artifacts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0015Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
    • A61B5/0022Monitoring a patient using a global network, e.g. telephone networks, internet
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/0205Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14542Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring blood gases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • A61B5/7207Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise induced by motion artifacts
    • A61B5/721Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise induced by motion artifacts using a separate sensor to detect motion or using motion information derived from signals other than the physiological signal to be measured
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235Details of waveform analysis
    • A61B5/7253Details of waveform analysis characterised by using transforms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235Details of waveform analysis
    • A61B5/7253Details of waveform analysis characterised by using transforms
    • A61B5/7257Details of waveform analysis characterised by using transforms using Fourier transforms
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
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    • G06N3/044Recurrent networks, e.g. Hopfield networks
    • GPHYSICS
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    • G06N3/045Combinations of networks
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/02Neural networks
    • G06N3/08Learning methods

Abstract

The invention relates to a dynamic vital sign signal acquisition system, a monitoring device and equipment, wherein the system comprises a dynamic vital sign signal acquisition module, a dynamic vital sign signal processing module and a dynamic vital sign signal processing module, wherein the dynamic vital sign signal acquisition module is used for acquiring a vital sign signal of an individual in a motion state to obtain a vital sign signal containing motion noise; the inertial navigation signal acquisition module is used for synchronously acquiring inertial navigation signals of an individual in a motion state; the denoising module is used for analyzing and processing the inertial navigation signal and the vital sign signal containing the motion noise which are synchronously acquired based on a denoising network model trained in advance to obtain the vital sign signal without the motion noise. According to the invention, the denoising module based on the denoising network model is combined with the inertial navigation signal to perform motion denoising processing on the individual vital sign signals in motion, so that accurate vital sign signals can be obtained, and the influence of motion on accurate acquisition of vital sign signals is overcome.

Description

Dynamic vital sign signal acquisition system, monitoring device and equipment
Technical Field
The invention relates to the field of vital sign signal monitoring, in particular to a dynamic vital sign signal acquisition system, a monitoring device and equipment.
Background
Degree of blood oxygen saturation (SpO) 2 ) Heart rate (BP) is a key indicator of constant human vital signs. Degree of blood oxygen saturation (SpO) 2 ) Existing measurement schemes related to heart rate (BP) tend to fall into three modes: i.e., the sensor is placed at the forehead, ear, or finger tip. The common measurement scheme is finger measurement, and the muscle at the finger end is less, so that the myoelectric interference in the measurement process is less, and the stability is better. The measurement results are often displayed directly on the measurement device, and are not transmitted to a remote terminal, nor are they analyzed. In the measuring process, the person is required to be in a static state and cannot move, otherwise, the measuring effect is very inaccurate. The existing measurement scheme cannot solve the blood oxygen and heart rate measurement of people under the dynamic condition. At present, there is no oneThe product can carry out the measurement of blood oxygen under the motion state, and its root cause lies in the photoelectric tube that blood oxygen device adopted in order to accomplish to measure accurately, often makes very high with its perception sensitivity, and such benefit is that it can measure the small change of blood oxygen value, and then improves measurement accuracy. However, a side effect of this arrangement is that it is very sensitive to the effects of other disturbances, such as motion disturbances. The multiplicative noise caused by the motion disturbance to the blood oxygen signal is often very large, and the useful blood oxygen signal is submerged under the noise. These noises often do not have a fixed frequency or other characteristics and are therefore difficult to filter by conventional signal processing means.
Disclosure of Invention
The invention aims to provide a dynamic vital sign signal acquisition system, a monitoring device and equipment, which can accurately acquire vital sign signals of individuals in motion and monitor vital sign values and overcome the influence of motion on the accurate acquisition of the vital sign signals.
The technical scheme for solving the technical problems is as follows: a dynamic vital sign signal acquisition system comprises the following modules,
the dynamic vital sign signal acquisition module is used for acquiring vital sign signals of an individual in a motion state to obtain the vital sign signals containing motion noise;
the inertial navigation signal acquisition module is used for synchronously acquiring inertial navigation signals of an individual in a motion state;
and the denoising module is used for analyzing and processing the synchronously acquired inertial navigation signals and the vital sign signals containing the motion noise based on a pre-trained denoising network model to obtain the vital sign signals without the motion noise.
Based on the dynamic vital sign signal acquisition system, the invention also provides a dynamic vital sign monitoring device.
A dynamic vital signs monitoring device comprises a dynamic vital signs signal processing system and the dynamic vital signs signal acquisition system as described above;
the dynamic vital sign signal processing system is used for processing the vital sign signals which are collected by the dynamic vital sign signal collecting system and are removed of the motion noise to obtain vital sign values;
the vital sign signals with the motion noise removed comprise blood oxygen signals and heart rate signals with the motion noise removed, and correspondingly, the vital sign values comprise blood oxygen values and heart rate values;
the dynamic vital sign signal processing system comprises in particular the following modules,
the wavelet transformation module is used for performing wavelet transformation processing on the original sequence of the vital sign signals with the motion noise removed to obtain a wavelet transformation signal sequence;
a Fourier transform module for obtaining a heart rate value by performing Fourier transform on the wavelet transform signal sequence;
the difference processing module is used for carrying out difference processing on the wavelet transformation signal sequence to obtain a difference signal sequence;
the sliding window filtering module is used for performing sliding window filtering on the differential signal sequence to obtain a sliding window filtering signal sequence;
the zero-crossing detection module is used for carrying out zero-crossing detection on the sliding window filtering signal sequence to obtain an extreme point set;
the redundancy elimination module is used for eliminating abnormal extreme points in the extreme point set to obtain a redundancy elimination extreme point set;
an extreme value fine-trimming module, configured to perform fine trimming on positions of the redundant elimination extreme points in the redundant elimination extreme point set to obtain a fine-trimmed extreme point set;
the R value calculation module is used for calculating an initial blood oxygen value according to the refined extreme point set;
and the Kalman filtering module is used for carrying out Kalman filtering on the initial blood oxygen value to obtain a final blood oxygen value after filtering.
Based on the dynamic vital sign monitoring device, the invention also provides dynamic vital sign monitoring equipment.
A dynamic vital sign monitoring device comprises an intelligent gateway, a remote monitoring terminal and the dynamic vital sign monitoring device;
the dynamic vital sign monitoring device is in communication connection with the remote monitoring terminal through the intelligent gateway.
The invention has the beneficial effects that: in the dynamic vital sign signal acquisition system, the denoising module based on the denoising network model is combined with the inertial navigation signal to perform denoising processing on the vital sign signal of an individual in motion, so that an accurate vital sign signal can be obtained, the influence of motion on accurate acquisition of the vital sign signal is overcome, a guarantee can be provided for a dynamic vital sign monitoring device to accurately calculate the vital sign value, and the vital sign value of the individual in motion is accurately monitored; in addition, the dynamic vital sign monitoring device transmits the monitored vital sign value to the remote monitoring terminal through the intelligent gateway, so that the vital signs can be remotely monitored.
Drawings
Fig. 1 is a block diagram of a dynamic vital sign signal acquisition system according to the present invention;
FIG. 2 is a block diagram of a denoising network model training module;
FIG. 3 is a frame diagram of an initial denoised network model;
FIG. 4 is a block diagram of a dynamic vital signs monitoring device according to the present invention;
fig. 5 is a block diagram of a dynamic vital signs monitoring device according to the present invention.
Detailed Description
The principles and features of this invention are described below in conjunction with the following drawings, which are set forth to illustrate, but are not to be construed to limit the scope of the invention.
As shown in fig. 1, a dynamic vital sign signal acquisition system comprises the following modules,
the dynamic vital sign signal acquisition module is used for acquiring vital sign signals of an individual in a motion state to obtain the vital sign signals containing motion noise;
the inertial navigation signal acquisition module is used for synchronously acquiring inertial navigation signals of the individual in a motion state;
and the denoising module is used for analyzing and processing the synchronously acquired inertial navigation signals and the vital sign signals containing the motion noise based on a pre-trained denoising network model to obtain the vital sign signals without the motion noise.
It should be noted that: in the signal acquisition process, the acquisition actions of the dynamic vital sign signal acquisition module and the inertial navigation signal acquisition module are strictly synchronous so as to overcome the influence caused by the decoupling motion of a subsequent denoising network model.
In this particular embodiment: the dynamic vital sign signal acquisition system further comprises a denoising network model training module, wherein the denoising network model training module is used for training the initial denoising network model to obtain a trained denoising network model;
as shown in fig. 2, the denoised network model training module specifically includes the following units,
the dynamic vital sign signal sample acquisition unit is used for acquiring a vital sign signal of a sample in a motion state to obtain a vital sign signal sample containing motion noise;
the inertial navigation signal sample acquisition unit is used for synchronously acquiring an inertial navigation signal sample of the sample in a motion state;
the real vital sign signal sample acquisition unit is used for synchronously acquiring the vital sign signals of the samples at the moment when the motion state stops to obtain real vital sign signal samples;
and the denoising network model training unit is used for inputting the real vital sign signal sample, the inertial navigation signal sample and the vital sign signal sample containing the motion noise which are synchronously acquired into the initial denoising network model for training to obtain the trained denoising network model.
The denoising network model adopted by the invention is a deep neural network, so a large number of labeled signal samples are needed to train the deep neural network, the acquisition of the signal samples is extremely troublesome, the real vital sign signals of an individual in the motion process need to be accurately measured, and the problem to be solved by the invention is that no special equipment exists at present. The blood oxygen signal interfered in the motion state and the corresponding real value are not existed at present. In order to solve the problem of acquiring enough data, the invention provides a new acquisition method. Firstly: the method comprises the following steps that a person is in a motion state including walking, running, shaking and the like, and at the moment, a dynamic vital sign signal sample collecting unit starts to collect vital sign signal samples (including motion noise); then, at some point, the individual is allowed to stop momentarily, such as lying in a comfortable place, while still collecting vital sign signal samples (containing no motion noise). Since the vital signs of the individual cannot change suddenly at the moment of stopping the exercise, when the stopping time is very short, such as 10 seconds or 30 seconds, the vital signs of the individual, including the blood oxygen value, can be the same as the value at the moment of the previous exercise state, so that the purpose of acquiring the real vital sign signal sample of the individual in the exercise state is achieved. In order to collect the vital sign signal samples, two collecting units, namely a dynamic vital sign signal sample collecting unit and a real vital sign signal sample collecting unit, can be deployed on the sample body, the dynamic vital sign signal sample collecting unit is disposed at the head end, and the real vital sign signal sample collecting unit is disposed at the finger end. When the finger tip is still, the influence caused by rapid respiration is small, so that the finger tip can be closer to the real vital sign. In the process of collecting the vital sign signal samples, the time of the motion state collection process is long, and the stop state can only be kept for a short time, such as 10s or even shorter, in order to ensure that the measured vital sign signal samples are close to the real motion state.
It should be noted that: in the signal acquisition process, the acquisition actions of the dynamic vital sign signal sample acquisition unit, the inertial navigation signal sample acquisition unit and the real vital sign signal sample acquisition unit are strictly synchronous, so that the training precision of the denoising network model is improved.
In addition, the dynamic vital sign signal sample acquisition unit and the dynamic vital sign signal acquisition module can be the same device, and the inertial navigation signal sample acquisition unit and the inertial navigation signal acquisition module can be the same device.
As shown in fig. 3, the initial denoising network model is specifically a UNet network with skip connection (residual connection) (UNet is a well-known image segmentation network in medical image processing), the UNet network includes a plurality of stacked coding layers and a plurality of stacked decoding layers, and further includes an output layer, the bottommost coding layer is connected to the inertial navigation signal samples and the vital sign signal samples containing motion noise, and the bottommost decoding layer is connected to the output layer; the encoding layer at the top layer is connected with the decoding layer at the top layer through an embedding layer, and the embedding layer is specifically an LSTM layer (the LSTM is a long-short term memory network and is a time cycle neural network); the LSTM layer is accessed with a feature loss layer, and the feature loss layer is accessed with a real vital sign signal sample synchronously acquired through a pre-training network layer; the output layer has access to a loss of vital sign (R, BP) layer.
Specifically, the feature loss signal generated in the feature loss layer is obtained by a distance L1 between the first low-dimensional signal and the second low-dimensional signal; wherein the first low-dimensional signal is obtained by directly extracting the real vital sign signal sample through the pre-training network layer, and the second low-dimensional signal is generated by the inertial navigation signal sample and the vital sign signal sample containing motion noise;
the vital sign value loss signal generated in the vital sign value loss layer is obtained from the distance L2 between the real vital sign signal sample and the output of the output layer at the calculated vital sign signal (in other words, the vital sign value loss signal generated in the vital sign value loss layer is obtained from the distance L2 between a and B, where a is the real vital sign signal sample and B is the calculated vital sign signal at the output of the output layer).
In other embodiments, the denoising network model may also use a cGAN network, and may also use other networks commonly used for images based on STFT input, such as a complex network.
In this particular embodiment: the vital sign signals are specifically blood oxygen signals and heart rate signals;
the dynamic vital sign signal sample acquisition unit is specifically used for acquiring a blood oxygen signal and a heart rate signal of a head end of a sample in a motion state to obtain a vital sign signal sample containing motion noise;
the real vital sign signal sample acquisition unit is specifically used for synchronously acquiring blood oxygen signals and heart rate signals of finger ends of the samples at the moment when the motion state stops, so as to obtain real vital sign signal samples.
Further, the dynamic vital sign signal acquisition module is specifically configured to acquire an blood oxygen signal and a heart rate signal of a head end of an individual in a motion state, so as to obtain a vital sign signal including motion noise.
Further, the expression of the entire loss signal composed of the feature loss signal and the vital sign value loss signal is,
Figure BDA0002937000690000071
wherein R is F And f F Respectively, a blood oxygen value and a heart rate value, R, obtained from the real vital sign signal samples H And f H Respectively a blood oxygen value and a heart rate value obtained after a vital sign signal sample containing motion noise passes through a Generator (a term of a denoising network model),
Figure BDA0002937000690000072
and
Figure BDA0002937000690000073
respectively calculating the ith element of the embedding layer obtained by the real vital sign signal sample and the vital sign signal sample containing the motion noise; alpha and beta are respectively hyper-parameters (hyper-parameters are parameters which can be adjusted), and L is the whole ios signal.
In this particular embodiment: the dynamic vital sign signal acquisition system further comprises a denoising network model integration module, wherein the denoising network model embedding module is used for compressing the network weight by quantizing, pruning and knowledge distilling the network weight of the trained denoising network model, and integrating the trained denoising network model with the compressed network weight into an embedded network to obtain the denoising module;
the denoising module is specifically used for operating the trained denoising network model with the compressed network weight in the embedded network, and analyzing and processing the inertial navigation signal and the vital sign signal containing the motion noise which are synchronously acquired, so as to obtain the vital sign signal without the motion noise.
Since the vital sign signal output by the denoising network model and subjected to motion noise removal is a waveform, and is not the final required vital sign values, such as the R value (blood oxygen value) and the BP value (heart rate value), further processing is required on the vital sign signal subjected to motion noise removal. At this time, the motion noise in the vital sign signal from which the motion noise is removed has been filtered, so that the following dynamic vital sign monitoring apparatus may be adopted to further process the vital sign signal from which the motion noise is removed, so as to obtain the vital sign value.
As shown in fig. 4, a dynamic vital signs monitoring device comprises a dynamic vital signs signal processing system and the dynamic vital signs signal acquisition system as described above;
the dynamic vital sign signal processing system is used for processing the vital sign signals which are collected by the dynamic vital sign signal collecting system and are removed of the motion noise to obtain vital sign values; the dynamic vital sign signal processing system can adopt an ultra-low power consumption singlechip or other embedded processors.
The vital sign signals with the motion noise removed comprise blood oxygen signals and heart rate signals with the motion noise removed, and correspondingly, the vital sign values comprise blood oxygen values and heart rate values;
the dynamic vital sign signal processing system comprises in particular the following modules,
the wavelet transformation module is used for performing wavelet transformation processing on the original sequence of the vital sign signals with the motion noise removed to obtain a wavelet transformation signal sequence;
a Fourier transform module for obtaining a heart rate value by performing Fourier transform on the wavelet transform signal sequence;
the difference processing module is used for carrying out difference processing on the wavelet transformation signal sequence to obtain a difference signal sequence;
the sliding window filtering module is used for performing sliding window filtering on the differential signal sequence to obtain a sliding window filtering signal sequence;
the zero-crossing detection module is used for carrying out zero-crossing detection on the sliding window filtering signal sequence to obtain an extreme point set;
the redundancy elimination module is used for eliminating abnormal extreme points in the extreme point set to obtain a redundancy elimination extreme point set;
an extreme value fine-trimming module, configured to perform fine trimming on positions of the redundant elimination extreme points in the redundant elimination extreme point set to obtain a fine-trimmed extreme point set;
the R value calculation module is used for calculating an initial blood oxygen value according to the refined extreme point set;
and the Kalman filtering module is used for carrying out Kalman filtering on the initial blood oxygen value to obtain a final blood oxygen value after filtering.
In this particular embodiment:
the dynamic vital sign signal processing system further comprises a first-in first-out queue module,
the first-in first-out queue module is used for storing the detected vital sign signals with the motion noise removed to obtain an original sequence of the vital sign signals with the motion noise removed, and transmitting the original sequence of the vital sign signals with the motion noise removed to the wavelet transform module in a first-in first-out mode after the original sequence is fully stored;
wherein, the length of the first-in first-out queue in the first-in first-out queue module is N, then the first-in first-out queue moduleThe motion noise-removed vital sign signal original sequence obtained by storing the motion noise-removed vital sign signal in the de-queue module is represented as
Figure BDA0002937000690000091
Original sequence of vital sign signals for removing motion noise, x n For the nth motion noise removed vital sign signal in the original sequence of motion noise removed vital sign signals, N =1,2, ·, N;
the method is characterized in that a small amount of high-frequency noise often exists in an original sequence of the vital sign signal for removing the motion noise under the action of electromyographic signals or external electromagnetic interference, and the specific expression is that a plurality of burrs exist in the signal, if the burr signals are not eliminated, the subsequent peak detection is influenced, and therefore the finally calculated blood oxygen value is greatly influenced. In order to eliminate the high-frequency interference, the original sequence of the vital sign signals with the motion noise removed enters a wavelet transform module to be subjected to wavelet transform processing.
In the wavelet transform module, the wavelet transform signal sequence obtained after the wavelet transform processing is performed on the original sequence x of the vital sign signals without the motion noise is represented as
Figure BDA0002937000690000101
And is
Figure BDA0002937000690000102
x′ n Is the n-th wavelet transform signal in the wavelet transform signal sequence, specifically, x' n Vital sign signal x for removing motion noise n And obtaining a wavelet transform signal after wavelet transform processing.
After the original sequence of the vital sign signals without the motion noise is subjected to wavelet transform processing by the wavelet transform module, most high-frequency noise is filtered out, and a wavelet transform signal is obtained. Because the heart rate signal is a periodic signal, the wavelet transform signal obtained after filtering is subjected to Fourier transform at the moment, and the heart rate value can be obtained.
In the Fourier transform module, the heart rate value is calculated by the formula,
BP=arg max(X),s.t.L<X<H;
wherein, BP is the heart rate value, X is a Fourier transform signal obtained by fast Fourier transform of the wavelet transform signal sequence, and
Figure BDA0002937000690000103
f () represents a fast fourier transform, and L and H represent a boundary minimum value and a boundary maximum value to be sought in the fast fourier transform, respectively. The normal fluctuation range of the human body is recorded as 60-100 times/minute,
Figure BDA0002937000690000104
where N represents the number of points used in the calculation of the FFT (fast Fourier transform), i.e. the length of the FIFO queue, F s Representing the sampling rate.
To obtain blood oxygen values, wavelet transformed signals
Figure BDA0002937000690000108
Firstly, the difference processing is carried out in a difference processing module.
In the difference processing module, the formula for performing difference processing on the wavelet transform signal sequence is as follows,
Figure BDA0002937000690000105
wherein the content of the first and second substances,
Figure BDA0002937000690000106
for the purpose of the sequence of differential signals,
Figure BDA0002937000690000107
and is a differential signal in the sequence of differential signals.
In the sliding window filtering module, the obtained sliding window filtering signal sequence is represented as
Figure BDA0002937000690000111
The sliding window filtering of the differential signal sequence is formulated as,
Figure BDA0002937000690000112
wherein the content of the first and second substances,
Figure BDA0002937000690000113
filtering the signal sequence for the sliding window
Figure BDA0002937000690000114
The kth sliding window of (b) filters the signal, W being the size of the sliding window.
In the zero-crossing detection module, the formula for performing zero-crossing detection on the sliding window filtering signal sequence is as follows,
Figure BDA0002937000690000115
wherein ZP is the extreme point set.
The extreme point set ZP contains all the extreme points, and due to the existence of noise, these extreme points may contain some local extreme values, and do not represent that it is an extreme value, and a local maximum or a local minimum value that is required for calculating the blood oxygen value, so it is necessary to further filter the extreme points in the extreme point set ZP. The extreme points of these anomalies are often more concentrated and less spaced by a large number of measurements, so these local extreme values are removed by using this information of spacing.
In the redundancy elimination module, the formula for eliminating the abnormal extreme points in the extreme point set is as follows,
Figure BDA0002937000690000116
wherein ZP' is the set of redundancy elimination extrema, I k Is composed of
Figure BDA0002937000690000117
Corresponding serial numbers, i.e.
Figure BDA0002937000690000118
In the position of I k -I k-1 To represent
Figure BDA0002937000690000119
And with
Figure BDA00029370006900001110
H is a preset first threshold.
The extreme point in the redundancy elimination extreme point set obtained after the processing of the redundancy elimination module is an extreme point which may be needed and is also a maximum point; however, since the sliding window filtering is adopted in the foregoing step, the positions of these extreme points need to be further refined.
In the extreme value refining module, the formula for refining the position of the redundancy elimination extreme point in the redundancy elimination extreme point set is as follows,
Figure BDA0002937000690000121
wherein ZP' is the finishing extreme point set, M is a preset second threshold value,
Figure BDA0002937000690000122
represents the sequence number I k The corresponding blood oxygen value is measured by the blood oxygen measuring instrument,
Figure BDA0002937000690000123
represent
Figure BDA0002937000690000124
Is a local extremum.
And the refined extreme points in the refined extreme point set obtained after the processing of the extreme value refining module are used as the extreme points for finally calculating the blood oxygen value.
In the R value calculation module, the formula for calculating the initial blood oxygen value is as follows,
Figure BDA0002937000690000125
wherein R is i Is the initial blood oxygen value, x i,max For the local pole, maximum, x, obtained from the IR sensor in the refined extreme point set ZP ″ i,min For the local pole, minimum, y from the IR sensor in the refined extreme point set ZP ″ i,max For the local pole, maximum, y, from the RED sensor in the refined extreme point set ZP ″ i,min Local poles and minimum values obtained from the RED sensor in the fine extreme point set ZP' are obtained; RED and IR sensors are sensors used to acquire vital sign signals containing motion noise.
In the Kalman filtering module, the final blood oxygen value is calculated by the formula,
R(k)=R′(k)+K(R z (k)-H*R′(k));
wherein R (k) is the final blood oxygen value calculated at the time k, R z (k) For the blood oxygen value measured at time K, R' (K) is the blood oxygen value updated at time K, K is kalman gain and K =1,H is the transformation matrix and H =1; r' (K) = AR (K-1), K = HP/(HPH) T +R),P=AP′A T + Q, P '= P-HKP, P is estimated state variable, P' is updated state variable, R is the initial blood oxygen value R i Obtaining a blood oxygen value after Kalman filtering, wherein A is an update matrix and A =1,Q is an observed covariance;
Figure BDA0002937000690000126
in particular, the alpha scale factor, here relates the covariance to the value of the change in the observed variable.
Based on the dynamic vital sign monitoring device, the invention also provides dynamic vital sign monitoring equipment.
As shown in fig. 5, a dynamic vital signs monitoring device includes an intelligent gateway, a remote monitoring terminal, and the dynamic vital signs monitoring apparatus as described above;
the dynamic vital sign monitoring device is in communication connection with the remote monitoring terminal through the intelligent gateway.
In the dynamic vital sign monitoring device of the present invention, the dynamic vital sign monitoring device is provided with a wireless transmission module, such as LoRa, NBIoT or a low power consumption high speed module, such as bluetooth, and the dynamic vital sign monitoring device transmits the measured vital sign value to the intelligent gateway through the wireless transmission module. The intelligent gateway is used for receiving the vital sign values transmitted by different dynamic vital sign monitoring devices and forwarding the vital sign values to the remote monitoring terminal for analysis and early warning.
In the dynamic vital sign signal acquisition system, the denoising module based on the denoising network model is combined with the inertial navigation signal to perform denoising processing on the vital sign signals of the individual in motion, so that accurate vital sign signals can be obtained, a guarantee can be provided for a dynamic vital sign monitoring device to accurately calculate the vital sign values, and the vital sign values of the individual in motion can be accurately monitored; in addition, the dynamic vital sign monitoring device transmits the monitored vital sign value to the remote monitoring terminal through the intelligent gateway, so that the vital signs can be remotely monitored.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims (6)

1. A dynamic vital sign signal acquisition system, characterized by: comprises the following modules which are used for realizing the functions of the system,
the dynamic vital sign signal acquisition module is used for acquiring vital sign signals of an individual in a motion state to obtain the vital sign signals containing motion noise;
the inertial navigation signal acquisition module is used for synchronously acquiring inertial navigation signals of the individual in a motion state;
the denoising module is used for analyzing and processing the inertial navigation signal and the vital sign signal containing the motion noise which are synchronously acquired based on a pre-trained denoising network model to obtain the vital sign signal without the motion noise;
the system also comprises a denoising network model training module, wherein the denoising network model training module is used for training the initial denoising network model to obtain a trained denoising network model;
the denoised network model training module comprises in particular the following elements,
the dynamic vital sign signal sample acquisition unit is used for acquiring a vital sign signal of a sample in a motion state to obtain a vital sign signal sample containing motion noise;
the inertial navigation signal sample acquisition unit is used for synchronously acquiring an inertial navigation signal sample of the sample in a motion state;
the real vital sign signal sample acquisition unit is used for synchronously acquiring the vital sign signals of the samples at the moment when the motion state stops to obtain real vital sign signal samples;
the denoising network model training unit is used for inputting a real vital sign signal sample, an inertial navigation signal sample and a vital sign signal sample containing motion noise which are synchronously acquired into the initial denoising network model for training to obtain a trained denoising network model;
the initial denoising network model is specifically a UNet network with skip connection, the UNet network comprises a plurality of stacked coding layers, a plurality of stacked decoding layers and an output layer, the coding layer at the bottom layer is connected with an inertial navigation signal sample and a vital sign signal sample containing motion noise, which are synchronously acquired, and the decoding layer at the bottom layer is connected with the output layer; the encoding layer at the top layer is connected with the decoding layer at the top layer through an embedding layer, and the embedding layer is specifically an LSTM layer; the LSTM layer is accessed with a featurelos layer, and the featurelos layer is accessed with real vital sign signal samples which are synchronously acquired through a pre-training network layer; the output layer is accessed with a life characteristic value loss layer;
the featurelos signal generated in the featurelos layer is obtained by the distance L1 between the first low-dimensional signal and the second low-dimensional signal; wherein the first low-dimensional signal is obtained by directly extracting the real vital sign signal sample through the pre-training network layer, and the second low-dimensional signal is generated by the inertial navigation signal sample and the vital sign signal sample containing motion noise;
the vital sign value loss signal generated in the vital sign value loss layer is obtained by the distance L2 between the real vital sign signal sample and the output of the output layer in the calculated vital sign signal;
the expression of the entire loss signal formed by the featureless signal and the loss signal is,
Figure FDA0003820244720000021
wherein R is F And f F Respectively, a blood oxygen value and a heart rate value, R, obtained from the real vital sign signal samples H And f H Respectively is a blood oxygen value and a heart rate value obtained after a vital sign signal sample containing motion noise passes through the denoising network model,
Figure FDA0003820244720000022
and
Figure FDA0003820244720000023
respectively calculating the ith element of the embedding layer obtained by the real vital sign signal sample and the vital sign signal sample containing the motion noise; both alpha and beta are hyperparameters, and L is the entire loss signal.
2. The dynamic vital sign signal acquisition system of claim 1, wherein: the vital sign signals are specifically blood oxygen signals and heart rate signals;
the dynamic vital sign signal sample acquisition unit is specifically used for acquiring a blood oxygen signal and a heart rate signal of a head end of a sample in a motion state to obtain a vital sign signal sample containing motion noise;
the real vital sign signal sample acquisition unit is specifically used for synchronously acquiring blood oxygen signals and heart rate signals of finger ends of the samples at the moment when the motion state stops, so as to obtain real vital sign signal samples.
3. The dynamic vital sign signal acquisition system of claim 1, wherein: the dynamic vital sign signal acquisition module is specifically used for acquiring blood oxygen signals and heart rate signals of the head end of an individual in a motion state to obtain vital sign signals containing motion noise.
4. Dynamic vital sign signal acquisition system according to any one of claims 1 to 3, wherein: the denoising network model embedding module is used for compressing the network weight by quantizing, pruning and knowledge distilling the network weight of the trained denoising network model, and integrating the trained denoising network model with the compressed network weight into an embedded network to obtain the denoising module;
the denoising module is specifically used for operating the trained denoising network model with the compressed network weight in the embedded network, and analyzing and processing the inertial navigation signal and the vital sign signal containing the motion noise which are synchronously acquired, so as to obtain the vital sign signal without the motion noise.
5. A dynamic vital sign monitoring device, comprising: comprising a dynamic vital signs signal processing system and a dynamic vital signs signal acquisition system as claimed in any one of claims 1 to 4;
the dynamic vital sign signal processing system is used for processing the vital sign signals which are collected by the dynamic vital sign signal collecting system and are removed of the motion noise to obtain vital sign values;
the vital sign signals with the motion noise removed comprise blood oxygen signals and heart rate signals with the motion noise removed, and correspondingly, the vital sign values comprise blood oxygen values and heart rate values;
the dynamic vital sign signal processing system comprises in particular the following modules,
the wavelet transformation module is used for performing wavelet transformation processing on the original sequence of the vital sign signals with the motion noise removed to obtain a wavelet transformation signal sequence;
a Fourier transform module for obtaining a heart rate value by performing Fourier transform on the wavelet transform signal sequence;
the differential processing module is used for carrying out differential processing on the wavelet transformation signal sequence to obtain a differential signal sequence;
the sliding window filtering module is used for performing sliding window filtering on the differential signal sequence to obtain a sliding window filtering signal sequence;
the zero-crossing detection module is used for carrying out zero-crossing detection on the sliding window filtering signal sequence to obtain an extreme point set;
the redundancy elimination module is used for eliminating abnormal extreme points in the extreme point set to obtain a redundancy elimination extreme point set;
an extreme value fine-trimming module, configured to perform fine trimming on positions of the redundant elimination extreme points in the redundant elimination extreme point set to obtain a fine-trimmed extreme point set;
the R value calculation module is used for calculating an initial blood oxygen value according to the refined extreme point set;
and the Kalman filtering module is used for carrying out Kalman filtering on the initial blood oxygen value to obtain a filtered final blood oxygen value.
6. A dynamic vital signs monitoring device, characterized by: comprising an intelligent gateway and a remote monitoring terminal and a dynamic vital signs monitoring device according to claim 5;
the dynamic vital sign monitoring device is in communication connection with the remote monitoring terminal through the intelligent gateway.
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