CN112934297A - Auxiliary device for animal toxicology experiment for biological medicine - Google Patents
Auxiliary device for animal toxicology experiment for biological medicine Download PDFInfo
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- CN112934297A CN112934297A CN202110170131.4A CN202110170131A CN112934297A CN 112934297 A CN112934297 A CN 112934297A CN 202110170131 A CN202110170131 A CN 202110170131A CN 112934297 A CN112934297 A CN 112934297A
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Abstract
The invention belongs to the technical field of biological experiment equipment, and particularly relates to an auxiliary device for animal toxicology experiments for biological medicines. The device comprises two fixed components; the fixing component comprises a body half shell, a head half shell, two limb half shells and a grip, wherein the body half shell is fixed at the top of the body half shell, and the two limb half shells are fixed at two sides of the body half shell; the limb half shell is provided with a plurality of channels capable of placing limbs of animals; the body half shells of the two fixed components are connected in a rotating mode, or the head half shells of the two fixed components are connected in a rotating mode, and a body buffer extrusion component and a head buffer component are arranged in at least one fixed component. The device of the invention utilizes the two fixing components to respectively fix the body, the head and the four limbs of the animal, and the body part buffer extrusion component and the head part buffer component are tightly contacted with the animal body, thereby realizing the omnibearing fixation of the animal body and having high stability.
Description
Technical Field
The invention belongs to the technical field of biological experiment equipment, and particularly relates to an auxiliary device for animal toxicology experiments for biological medicines.
Background
Animal toxicology testing refers to observing the toxic response of an animal after administration of a particular substance to the animal. The administered drug may be a drug, a toxic compound, or the like. In general, toxicology experiments include a series of experiments on interaction between chemical substances (hereinafter referred to as "drugs") and animal organisms, such as determination of animal toxicity (referred to as diseases caused by exposure of the organism to the toxicant), absolute lethal dose (the lowest dose which can cause all of a group of animals to die), semi-lethal dose (the lowest dose which can cause half of a group of animals to die), minimum lethal dose (the highest dose which can cause all of a group of animals to survive severe poisoning without any death), maximum non-effective dose (referred to as the highest dose which cannot cause any harmful effects on the organism after exposure of exogenous substances to the organism within a certain period of time), and the like.
Because the homology between animals and human bodies is high, animal toxicology experiments are an important experimental process for verifying the safety and the toxicity of the medicine, the effect of the medicine in the human body can be estimated according to the animal reaction condition, and an important experimental basis is provided for the fields of medicine research and development and the like. At present, the most common experimental animals are mice or rabbits, which have the advantages of wide sources, easy feeding, convenient dissection and the like and are the primary choice objects of many biological medicine experiments.
In the process of animal toxicology experiments, specific medicines need to be fed or injected to animals, the animals can have resistance behaviors due to fright, poor tolerance and the like, and in order to ensure that the medicine administration is carried out smoothly, the animals need to be fixed by a fixing device or manpower firstly and then the medicines are administered. The manual fixing method needs at least two people to finish the operations of animal fixing and medicine administration, and consumes much manpower resources. The fixing device in the prior art comprises an operation table and a limb strap arranged on the operation table, however, for the medicine administration process of the living animal, when only the limb of the animal is bound, the body of the animal still shows the resistance action, and the fixing effect of the animal is still poor. In summary, in order to reduce the manpower consumption and improve the animal fixing effect, a toxicology experiment auxiliary device capable of fixing the animal body needs to be provided.
Disclosure of Invention
In order to solve the technical problems, the invention provides an auxiliary device for animal toxicology experiments for biological medicines, which is characterized in that the body, the head and four limbs of an animal are respectively fixed by two fixing components, and the body part buffering and extruding component and the head part buffering component are tightly contacted with the animal body, so that the omnibearing fixation of the animal body is realized, the stability is high, and the fixing effect is good.
The invention aims to provide an auxiliary device for animal toxicology experiments for biological medicines, which comprises two fixing components;
the fixing assembly includes:
the body half shell is used for placing animal body parts;
the head half shell is arranged at the top of the body half shell and is used for placing an animal neck or placing the neck and the head part;
the two limb half shells are respectively arranged on two sides of the body half shell, the limb half shells are provided with a plurality of channels capable of placing limbs of animals, and the plurality of channels are distributed along the length direction of the body half shell;
a grip mounted on the body half shell;
the body half shells of the two fixing components are rotatably connected, or the head half shells of the two fixing components are rotatably connected, and the two fixing components can be closed to form a fixing cavity for fixing an animal or unfolded to form a V shape; a body part buffer extrusion component is arranged in the body part half shell of at least one fixing component, and a head part buffer component is arranged in the head part half shell fixedly connected with the body part half shell; after the two fixing assemblies are closed and animals are not placed, the body part buffering and extruding parts and the head part buffering parts are in a natural unfolding state, and the circumference enclosed by the inner walls of the two opposite body part buffering and extruding parts and the circumference enclosed by the inner walls of the two opposite head part buffering parts are respectively smaller than the maximum body circumference and the head circumference of the experimental animals.
Preferably, in the auxiliary device for animal toxicology experiments in biomedical use, the body half shell is semi-ellipsoidal, semi-cylindrical or hemispherical.
Preferably, the head half shell is 1/4-1/3 ellipsoid, semi-cylindrical with a height of 2-3cm, 1/4-1/3 sphere, semi-ellipsoid or hemisphere.
Preferably, in the auxiliary device for animal toxicology experiments in biomedical science, the body buffering and squeezing component and the head buffering component are air bags, memory cotton or sponges with springs embedded inside.
Preferably, above-mentioned auxiliary device for animal toxicology experiment of biological medicine, the buffering extrusion part can be dismantled inlay in half casing of body, perhaps body buffering extrusion part's surface is fixed in half casing of body.
Preferably, in the auxiliary device for animal toxicology experiments in biomedical science, the body cushioning-pressing member and the inner surface of the body half shell are provided with a main magnetic member, one surface of the auxiliary magnetic member is magnetically attracted to the main magnetic member, and the other surface of the auxiliary magnetic member is detachably connected to the animal body.
Preferably, the auxiliary device for animal toxicology experiments in biomedical use further comprises fixing blocks, wherein the fixing blocks are mounted on the top outer side and the bottom outer side of the body half shell of any one of the fixing assemblies.
Preferably, in the auxiliary device for animal toxicology experiments in biomedical science, one of the fixing assemblies is provided with the body part buffering and pressing part and the head part buffering part; another the body half casing of fixed subassembly comprises fixed frame and a plurality of fly leaf, the one end of fly leaf with the one end of fixed frame is rotated and is connected, the other end of fly leaf with the connection can be dismantled to the other end of fixed frame.
Preferably, in the auxiliary device for animal toxicology experiments in biomedical science and medicine, the movable plate is in an arc surface shape protruding towards the inner side of the fixing component, and a large ellipsoid is formed by the arc surfaces of the movable plates.
Preferably, in the auxiliary device for animal toxicology experiments in biomedical use, the body half shell, the head half shell and the limb half shell of the two fixing components are provided with injection holes.
Compared with the prior art, the invention has the following beneficial effects:
1. the body half shell is used for placing animal body parts, the head half shell is used for placing animal necks or placing necks and head parts, the channels are used for placing animal limbs, the two fixing components are closed to fix the animal bodies, the heads and the limbs respectively, the body buffer extrusion component and the head buffer component can guarantee that the animal bodies have a shaping effect when deformed under pressure, and the animal bodies are in all-dimensional contact fixation, and are high in stability and good in fixing effect.
2. According to the invention, the number of the channels is multiple, and four limbs of the animal can be placed in different channels according to different body lengths of the animal, so that the comfort of the animal is improved, the limb injury in the drug administration process is reduced, and the influence of other factors except the drug on the body movement of the animal is reduced.
3. Because the device of the invention fixes one animal in one-to-one correspondence, the device is simple to operate and high in fixing efficiency, a plurality of animals can be fixed by a plurality of devices at the same time, and then the drug administration operation is carried out in batches, so that the difference of the drug administration time of each animal is small, and the statistics and comparison of the drug reaction of different animals are convenient.
4. According to the invention, the main magnetic part and the auxiliary magnetic part are arranged, the animal is firstly primarily fixed in the fixing component in a magnetic attraction mode, and then the two fixing components are closed, so that the double-fixing effect is achieved.
5. According to the animal feeding table, the fixing block is arranged, the medicine feeding operation can be carried out by placing the fixing block on the bottom surface, the table top or other table tops, the animals do not need to be transferred to a professional operation table, the operation can be carried out in the animal feeding place, and the convenience is high.
6. The injection hole is arranged, so that the position of the injection point is fixed, the injection point of the animal is conveniently and rapidly locked, and the experimental efficiency is improved.
Drawings
FIG. 1 is a schematic perspective view of the auxiliary device for toxicology test of animals for biomedical use of example 1;
FIG. 2 is a schematic view of the expanded configuration of FIG. 1;
FIG. 3 is a schematic structural view of the fixing assembly of FIG. 1;
FIG. 4 is a schematic perspective view of the auxiliary device for animal toxicology test in biomedical applications of example 2;
fig. 5 is an expanded structural view of fig. 4.
Detailed Description
In order that those skilled in the art will better understand the technical solutions of the present invention to be implemented, the present invention will be further described with reference to the following specific embodiments and accompanying drawings.
In the description of the present invention, it is to be understood that the terms "top" and "bottom" indicate orientations or positional relationships based on those shown in the drawings, and the terms "inner" and "outer" indicate orientations corresponding to a side of the device that contacts an animal and a side of the device that is away from the animal when in use, respectively, only for convenience of description and simplicity of description, and do not indicate or imply that the device or element so referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention. In the description of the present invention, "a plurality" means two or more unless otherwise specified.
Example 1
The auxiliary device for animal toxicology experiments for biomedicine provided by the embodiment comprises two symmetrically arranged fixing components, as shown in fig. 1-3, wherein each fixing component comprises a body half shell 1, a head half shell 2, two limb half shells 3 and a handle 4, the body half shell 1 is semi-ellipsoidal, semi-cylindrical, hemispherical and in a shape conforming to the half body shape of animals such as mice or rabbits, and the body half shell 1 is used for placing animal body parts; the head half shell 2 is fixed or installed on the top of the body half shell 1 through a screw, and is used for placing the neck of an animal or placing the neck and the head part, in order to conveniently feed medicines to the animal, the head half shell 2 can be in an 1/4-1/3 ellipsoid shape, a semi-cylindrical shape with the height of 2-3cm or a 1/4-1/3 spherical shape, after the device of the embodiment fixes the animal, the mouth of the animal is exposed out of the device, and the position below the neck and the mouth is fixed in the device; the two limb half shells 3 are respectively fixed on two sides of the body half shell 1 and are of a frame structure with a plurality of channels 31, the frame structure is of a cubic shape, a semi-cylindrical shape or a semi-ellipsoidal shape, the channels 31 are of the semi-cylindrical shape or the curved surface shape, the plurality of channels 31 are distributed along the length direction of the body half shell 1, and the channels 31 are used for placing limbs of animals. The grip 4 is mounted on the body half shell 1, preferably at the bottom of the body half shell 1, the grip 4 being intended to be held by the operator.
The body half shells 1 of the two fixing components are rotatably connected through a hinge or a rotating shaft, or the head half shells 2 of the two fixing components are rotatably connected through a hinge or a rotating shaft, so that the two fixing components can be closed to form a fixing cavity for fixing animals or unfolded to form a V shape. When the animal is not placed, the two fixing components are closed, see fig. 1, when the animal needs to be placed, the two fixing components are opened, see fig. 2, the animal is placed in the body half shell 1 and the head half shell 2 of one of the fixing components, an operator holds the handle 4 by hand to close the two fixing components, then the body, the head and the limbs of the animal are respectively fixed, and finally, the two body half shells 1 are locked together by utilizing the lock catches arranged on the two body half shells 1.
In the embodiment, in order to improve the animal fixing effect, a body part buffer extrusion component 11 is arranged in a body part half shell 1 of a fixing assembly, a head part half shell 2 fixedly connected with the body part half shell 1 is provided with a head part buffer component 21, the body part buffer extrusion component 11 is an air bag, memory cotton or sponge with a spring embedded inside, the buffer extrusion component 11 is detachably embedded in the body part half shell 1, when the buffer extrusion component 11 is embedded, the internal shape of the body part half shell 1 is matched with that of the body part half shell 11, or the outer surface of the body part buffer extrusion component 11 is fixed in the body part half shell 1; the inner surface of the body part buffer extrusion component 11 is used for contacting with the animal body; the head buffer part 21 is an air bag, memory cotton or sponge embedded with a spring inside, preferably, the head buffer part 21 has the same structure with the body buffer extrusion part 11, the head buffer part 21 is detachably embedded in the head half shell 2, and the head buffer part 21 is matched with the inner shape of the head half shell 2 when being embedded, or the outer surface of the head buffer part 21 is fixed in the head half shell 2; the inner surface of the head cushioning member 21 is adapted to contact the animal's body. When the animal is not placed, after the two fixing components are closed, the body buffering and extruding parts 11 and the head buffering parts 21 are in a natural unfolding state, the circumference surrounded by the inner walls of the two opposite body buffering and extruding parts 11 is smaller than the maximum circumference of the experimental animal, the circumference surrounded by the inner walls of the two opposite head buffering parts 21 is smaller than the circumference of the experimental animal, and preferably, the circumference surrounded by the inner walls of the two head buffering parts 21 is smaller than the circumference of the experimental animal neck. Taking a mouse as an example, since the waist of the mouse is the largest part of the whole body, the circumference enclosed by the inner walls of the two opposite body buffer pressing members 11 when the mouse is naturally unfolded should be smaller than the waist of the mouse. The purpose of the size design is to place an animal into the body buffering and extruding part 11 and the head buffering part 21 of one of the fixing assemblies, and gradually close the two fixing assemblies, the body buffering and extruding part 11 and the head buffering part 21 are gradually compressed, and because the body buffering and extruding part 11 and the head buffering part 21 adopted in the embodiment can be deformed, the body buffering and extruding part can be in close contact with the animal body in the process of being extruded by the animal, the materials of the body buffering and extruding part 11 and the head buffering part 21 selected in the embodiment can ensure that the animal body has a shaping effect when being deformed by pressure, and the omnibearing contact and fixation of the animal body is realized.
Because the fixed animal of device one-to-one of this embodiment, the easy operation that the device was opened and shut at one time, fixed efficient, can utilize a plurality of devices to fix a plurality of animals simultaneously, then carry out the medicine in batches and give the operation, then the time difference of dosing of every animal is little, is convenient for statistics and contrast the drug reaction of different animals.
Preferably, the body part buffering and squeezing component 11 and the inner surface of the body part half shell 1 are provided with main magnetic components, the main magnetic components are magnets or magnetic stickers, one surface of the auxiliary magnetic component is magnetically attracted on the main magnetic components, a magic tape or an adhesive tape is fixed on the other surface of the auxiliary magnetic component, the surface is detachably adhered to the body of an animal, the animal is primarily fixed in the fixing component through a magnetic attraction mode, then the two fixing components are closed, and a dual fixing effect is achieved;
preferably, the device of this embodiment still includes fixed block 6, and fixed block 6 is installed in the top outside and the bottom outside of body half casing 1 of arbitrary fixed subassembly, places fixed block 6 on the bottom surface, desktop or other mesas, can carry out the medicine and give the operation, need not shift the animal to on professional operation panel, can carry out the operation in animal feeding ground, and the convenience is high.
Example 2
The structure of the auxiliary device for animal toxicology experiments in biomedicine provided by the embodiment is basically the same as that of the embodiment 1, and the difference is that, referring to fig. 4-5, in order to enable the device of the invention to carry out visceral anatomy operation, only one fixing component is provided with a body part buffer pressing component 11 and a head part buffer component 21, the body part half shell 1 of the other fixing component consists of a fixing frame and a plurality of movable plates 12, one end of each movable plate 12 is rotatably connected with one end of the fixing frame through a hinge or a rotating shaft or a hinge, and the other end of each movable plate 12 is connected with the other end of the fixing frame through a lock catch, so that any movable plate 12 can be opened from the fixing frame. In the actual operation process, the side, which does not need to be dissected, of the animal is placed on the fixing assembly provided with the body buffering and pressing part 11 and the head buffering part 21, the side, which needs to be dissected, of the animal faces the fixing assembly provided with the body buffering and pressing part 11 and the head buffering part 21, the movable plate 12 in the corresponding position is opened according to the part needing to be dissected, the part of the animal is exposed in the environment, the dissection experiment is carried out, and other parts are still fixed in the device.
In this embodiment, in order to increase the fixing effect of the animal, the movable plate 12 is set to be in an arc shape protruding towards the inner side of the fixing component, the arc surfaces of the movable plates 12 form a large ellipsoid, and in the process of closing the two fixing components, the ellipsoid is used for extruding the animal, so that the animal is fixed between the ellipsoid and the body buffer extrusion component 11 and the head buffer component 21 of the other fixing component.
In order to conveniently inject medicine into animals, the head half shell 2 is semi-ellipsoidal, semi-spherical and in a shape conforming to the shape of the head of a half of an animal such as a mouse or a rabbit, the body half shell 1, the head half shell 2 and the limb half shell 3 of the two fixing components are all provided with injection holes 5, and the diameter of each injection hole 5 is larger than that of an injection needle so as to ensure that the injection needle of the injector can penetrate through the injection holes 5. Because this embodiment is all-round fixed to the animal body, then the corresponding injection point position is also fixed, can set up injection hole 5 positions according to the injection site position that the animal is commonly used, is convenient for lock the animal injection point fast, improves experimental efficiency.
It should be noted that, the connection relation of the components not specifically mentioned in the present invention is the default of the prior art, and the connection relation of the structures is not described in detail since it does not relate to the invention point and is a common application of the prior art.
It should be noted that, when the present invention relates to a numerical range, it should be understood that two endpoints of each numerical range and any value between the two endpoints can be selected, and since the steps and methods adopted are the same as those in the embodiment, in order to prevent redundancy, the present invention describes a preferred embodiment. While preferred embodiments of the present invention have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. Therefore, it is intended that the appended claims be interpreted as including preferred embodiments and all such alterations and modifications as fall within the scope of the invention.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.
Claims (10)
1. An auxiliary device for animal toxicology experiments for biological medicine is characterized by comprising two fixing components;
the fixing assembly includes:
a body half-shell (1) for placing an animal body part;
the head half shell (2) is arranged at the top of the body half shell (1) and is used for placing an animal neck or placing the neck and the head part;
the two limb half shells (3) are respectively installed on two sides of the body half shell (1), a plurality of channels (31) capable of placing animal limbs are arranged on the limb half shells (3), and the channels (31) are distributed along the length direction of the body half shell (1);
a grip (4) attached to the body half shell (1);
the body half shell (1) of the two fixing components or the head half shell (2) of the two fixing components are in rotary connection, and the two fixing components can be closed to form a fixing cavity for fixing animals or unfolded to form a V shape; a body part buffer extrusion component (11) is arranged in the body part half shell (1) of at least one fixed component, and a head part buffer component (21) is arranged in the head part half shell (2) fixedly connected with the body part half shell (1); after the two fixing assemblies are closed and animals are not placed, the body part buffering and extruding parts (11) and the head part buffering parts (21) are in a natural unfolding state, and the circumference enclosed by the inner walls of the two opposite body part buffering and extruding parts (11) and the circumference enclosed by the inner walls of the two opposite head part buffering parts (21) are respectively smaller than the maximum body circumference and the head circumference of the experimental animals.
2. The device for assisting the toxicology of animals for biopharmaceuticals according to claim 1, wherein the half-shell body (1) is semi-ellipsoidal, semi-cylindrical or hemispherical.
3. The biomedical assistance device for animal toxicology experiments according to claim 1, wherein the head half-shell (2) is in the shape of an 1/4-1/3 ellipsoid, a half-cylinder with a height of 2-3cm, a 1/4-1/3 sphere, a half-ellipsoid or a hemisphere.
4. The device as claimed in claim 2, wherein the body cushioning-compressing member (11) and the head cushioning member (21) are air bags, memory foam, or sponges with springs embedded therein.
5. The device for assisting the toxicology of animals for biopharmaceuticals according to claim 4, wherein the cushion-squeeze member (11) is detachably embedded in the body half shell (1), or an outer surface of the body cushion-squeeze member (11) is fixed in the body half shell (1).
6. The device for assisting the toxicology of animals for biopharmaceuticals, according to claim 5, wherein the inner surfaces of the body cushioning compression member (11) and the body half shell (1) are provided with a primary magnetic member, one surface of a secondary magnetic member being magnetically attracted to the primary magnetic member, the other surface of the secondary magnetic member being adapted for detachable attachment to the animal body.
7. The device for assisting the toxicology of animals for biopharmaceuticals, according to claim 1, further comprising fixing blocks (6), wherein the fixing blocks (6) are mounted on the top outer side and the bottom outer side of the body half-shell (1) of any of the fixing assemblies.
8. The auxiliary device for toxicology experiments of biopharmaceuticals for animals according to claim 1, wherein one of said fastening assemblies is provided with said body cushioning and compression member (11), said head cushioning member (21); another body half casing (1) of fixed subassembly comprises fixed frame and a plurality of fly leaf (12), the one end of fly leaf (12) with the one end of fixed frame is rotated and is connected, the other end of fly leaf (12) with the connection can be dismantled to the other end of fixed frame.
9. The auxiliary device for toxicology experiments of biopharmaceuticals and animals according to claim 8, wherein the movable plate (12) has a shape of arc protruding towards the inside of the fixed component, and the arc of the plurality of movable plates (12) forms a large ellipsoid.
10. The auxiliary device for the toxicology experiments of animals for biopharmaceuticals according to claim 1, wherein the body half shell (1), the head half shell (2) and the limb half shell (3) of both said fixing assemblies are provided with injection holes (5).
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| CN205659015U (en) * | 2016-05-05 | 2016-10-26 | 昆明医科大学 | Multi -functional toy fixing device of improvement |
| CN205913439U (en) * | 2016-05-26 | 2017-02-01 | 王洛 | Trunk fixing device |
| CN206576974U (en) * | 2016-11-08 | 2017-10-24 | 江苏农牧科技职业学院 | A kind of Multifunctional animal operating table |
| CN107007373A (en) * | 2017-04-14 | 2017-08-04 | 南方科技大学 | A kind of laboratory rodent fixing device |
| CN107693155A (en) * | 2017-09-14 | 2018-02-16 | 广东药科大学附属第医院 | Mesofauna stationary positioned device for nuclear magnetic resonance |
| CN208892832U (en) * | 2017-11-08 | 2019-05-24 | 甘肃中医药大学 | A kind of pharmacological experiment animal fixed bin |
| CN208756239U (en) * | 2018-05-28 | 2019-04-19 | 米度（南京）生物技术有限公司 | A kind of fixation device of experimental rat |
| CN209529388U (en) * | 2018-10-12 | 2019-10-25 | 中国人民解放军陆军军医大学 | A kind of multi-functional rat fixation kit |
| CN209347290U (en) * | 2018-10-15 | 2019-09-06 | 曲靖医学高等专科学校 | A kind of pharmacological experiment animal fixed bin |
| CN209847450U (en) * | 2019-02-21 | 2019-12-27 | 上海市中医医院 | Rat is applied ointment or plaster and is assisted fixed cylinder |
| CN109846576A (en) * | 2019-03-12 | 2019-06-07 | 郑荟莹 | A kind of biochemicals syringe for rodent experiment |
| CN211674690U (en) * | 2019-04-03 | 2020-10-16 | 中国科学院深圳先进技术研究院 | Animal surgery fixing device |
| CN210749644U (en) * | 2019-06-06 | 2020-06-16 | 北京市中医研究所 | Animal fixer for experiment |
| CN110547894A (en) * | 2019-09-27 | 2019-12-10 | 河北医科大学 | Nose-dropping experimental mouse fixing device |
| CN110584670A (en) * | 2019-09-30 | 2019-12-20 | 北京锐视康科技发展有限公司 | Medical imaging bearing cabin for experimental animals |
| CN110772351A (en) * | 2019-11-13 | 2020-02-11 | 重庆医药高等专科学校 | Mouse experimental device |
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Application publication date: 20210611 |