CN112934286A - Capillary tube liquid-transfering device - Google Patents
Capillary tube liquid-transfering device Download PDFInfo
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- CN112934286A CN112934286A CN202110251265.9A CN202110251265A CN112934286A CN 112934286 A CN112934286 A CN 112934286A CN 202110251265 A CN202110251265 A CN 202110251265A CN 112934286 A CN112934286 A CN 112934286A
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- 239000007788 liquid Substances 0.000 claims abstract description 59
- 239000000463 material Substances 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 abstract description 10
- 238000012546 transfer Methods 0.000 abstract description 10
- 238000005119 centrifugation Methods 0.000 abstract description 7
- 230000003044 adaptive effect Effects 0.000 abstract description 2
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 238000007664 blowing Methods 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 11
- 230000008569 process Effects 0.000 description 6
- 239000011248 coating agent Substances 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 230000006378 damage Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 239000004743 Polypropylene Substances 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000004907 flux Effects 0.000 description 3
- 238000007710 freezing Methods 0.000 description 3
- -1 polypropylene Polymers 0.000 description 3
- 229920001155 polypropylene Polymers 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000006557 surface reaction Methods 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
- B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
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- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Devices For Use In Laboratory Experiments (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The application belongs to the technical field of move liquid device, specifically discloses capillary liquid device, which comprises a panel, set up the same hole more than 1 at least on the panel, every the hole downwardly extending forms the capillary. The application has at least one of the following beneficial effects: the capillary liquid transfer device automatically sucks liquid into the capillary by utilizing the capillary phenomenon, the capillary is stably placed on the adaptive reaction container to be suspended, and then the liquid in the capillary flows out and is transferred into a new reaction container through operations such as centrifugation, vibration, whipping, airflow blowing and the like; multiple capillary array once only shifts many liquid, and good reproducibility has been avoided using single (many) passageway pipettor and has been relapseed many times to and because of the suction head differs with the leakproofness of single (many) passageway pipettor and causes the error of absorbing liquid, the capillary liquid-transfering device that this application provided need not to cooperate with the suction head and uses in addition, the cost of the suction head quantity has significantly reduced, has avoided the pollution that the suction head caused the environment.
Description
Technical Field
The application belongs to the technical field of move liquid device, and more specifically says, it relates to a capillary liquid device.
Background
In research and production laboratories, researchers often use multi-well plates for liquid phase/surface reactions, cell cultures, etc., where the well fluid may be used as a reaction system and the functional coating, affinity capture layer, or cell culture layer on the bottom or sidewall surface of the well may react with the liquid phase. Currently, methods of transferring liquids to multi-well plates include: (1) the liquid was aspirated one by one with a single channel pipettor and transferred to a multi-well plate. The method has low flux when transferring liquid, complicated operation and long time consumption, simultaneously consumes a large amount of suction heads matched with the pipettor, and easily causes errors of different degrees because the tightness of the suction heads and the pipettor is different or because the force for pressing the pipettor each time is different when performing a parallel test; (2) when a multi-channel liquid transfer device, such as an 8-channel liquid transfer device and a 12-channel liquid transfer device, is used for sucking liquid row by row and adding the liquid into a multi-hole plate, the method has the advantages of higher processing flux and less time consumption compared with the single-channel liquid transfer device, but still consumes a large amount of consumables such as a sucker. The process not only consumes time, material consumption and manpower, but also has insufficient automation degree, incomplete liquid transfer is easy to occur, the liquid suction volume of each channel is not uniform, the introduced uncertainty is increased, and the error is increased; the bottom and the wall of the reaction hole are easy to scratch, so that the experiment result is obviously influenced; (3) for transferring liquid to more well plates, e.g., 96 well plates, the liquid can be dispensed to additional 96 well plates and then aspirated at once and transferred to the 96 well plates using a pipetting station, which requires a pipetting station and is costly.
Disclosure of Invention
It is thus clear that, when shifting liquid to the perforated plate in the prior art, can't compromise flux, operating time, consumptive material consumption, and can't ensure not to damage reaction pore wall coating, consequently, this application provides a capillary liquid-transfering device for solving one of above-mentioned defect at least, and the device has reduced the operation degree of difficulty, has reduced experimental error, can ensure not contact reaction pore wall coating moreover, avoids the destruction of the biological structure of the material in the reaction hole.
The application is realized by the following scheme:
the application provides a capillary pipet, and it includes the panel, 1 hole has been seted up at least on the panel, the hole downwardly extending forms the capillary.
When the capillary in this application stretched into the liquid level that needs to shift under, utilized the capillary, liquid will rise and reach certain height along the pipe wall of capillary to the completion absorbs the process of liquid.
In a specific embodiment of the present application, the capillary pipetting device is adapted to a multi-well plate for simultaneously pipetting more than two wells in the multi-well plate at a time. The capillary pipetting device which has aspirated the liquid is placed above the multiwell plate, the capillary is inserted into the well of the multiwell plate, the multiwell plate is placed in a centrifuge for centrifugation, and the liquid in the capillary is transferred to the well of the multiwell plate by the action of the centrifugal force. Or by hand force, the liquid in the capillary is transferred to the wells of the multi-well plate.
In a specific embodiment of the present application, the multi-well plate is a 4-well plate, a 6-well plate, an 8-well plate, a 12-well plate, a 24-well plate, a 48-well plate, a 96-well plate, or a 384-well plate. For a capillary pipetting device adapted to a 4-well plate, the capillary pipetting device may be provided with 4 wells on the panel, each well extending down to form a capillary, forming a 4-well capillary pipetting device containing 4 capillaries. When transferring liquid to a 4-well plate using a 4-well capillary pipetting device, 4 capillaries vertically extend into 4 wells, and the liquid in the 4 capillaries is added to the 4 wells of the 4-well plate by centrifugal force or hand force. The same applies to capillary pipettes for 12-well plates, 24-well plates, 48-well plates, 96-well plates, or 384-well plates. The liquid may be transferred to a multi-well plate having a large number of wells by a capillary pipetting device having a small number of wells, for example, a 4-well capillary pipetting device may be used to transfer the liquid to an 8-well plate, a 12-well plate, a 24-well plate, a 48-well plate, a 96-well plate, or a 384-well plate.
In one embodiment of the present application, the capillary pipetting device is adapted to a 96-well plate, and the capillary pipetting device has 96 wells opened on a panel, each well extending downward to form a capillary, forming a 96-well capillary pipetting device containing 96 capillaries.
In one embodiment of the present application, the outer diameter of the capillary is smaller than the inner diameter of the well of the multiwell plate.
In one embodiment of the present application, the height of the capillary is less than the depth of the hole of the porous plate, so that the capillary cannot contact the bottom of the hole in the porous plate, and the damage of the capillary to the bottom of the hole or the influence of the reactant or the reaction solution at the bottom of the hole is avoided. Preferably, the height of the capillary is 1/3-2/3 of the depth of the well of the multiwell plate, for example 1/3, 1/2 or 2/3 of the depth of the well of the multiwell plate.
In one embodiment of the present application, the capillary tube is provided with scale symbols. The scale symbols are used to indicate that the user is provided with a means for determining the volume of liquid contained within the capillary tube.
In one embodiment of the present application, the capillary has an inner diameter of ≦ 2.5 mm. For example, the capillary has an inner diameter of 2.5mm, 2mm, 1.8mm, 1.5mm, 1.2mm, 1.0mm, 0.8mm, or 0.5mm, etc.
In one embodiment of the present application, the capillary pipetting device is made of a material selected from the group consisting of a metal or a polymer material. The specific material selection can be selected according to the hydrophilicity and hydrophobicity of the material, the mechanical strength, the maximum centrifugal force capable of bearing, the temperature of freezing and centrifuging, the temperature of high-temperature steam sterilization, wear-resisting experiments, molecular adsorption, whether the material has influence on the collected sample, the requirement on a capillary pipetting device in the experiment process and other factors. For example, if aseptic operation is required in the experimental process, high-temperature resistant materials such as metal and polypropylene can be selected; in addition, for example, in the experiment process, low-temperature freezing centrifugation is required, and anti-freezing materials such as metal, polypropylene, ABS resin and the like can be selected.
Another aspect of the present application provides a mold for manufacturing the capillary pipetting device described above.
The capillary liquid-transfering device that this application provided has at least one of following beneficial effect:
the capillary liquid transfer device provided by the application utilizes the capillary phenomenon to automatically suck liquid into the capillary, the capillary is stably placed on the adaptive reaction container to be suspended, and then the liquid in the capillary flows out and is transferred into a new reaction container through operations such as centrifugation, vibration, whipping, airflow blowing and the like; multiple capillary array once only shifts many liquid, and good reproducibility has avoided the operation many times repeatedly when using single (many) passageway pipettor to and differ because of the suction head and the leakproofness of single (many) passageway pipettor and cause the error of absorbing liquid, and the capillary that this application provided moves the liquid device and need not to cooperate the use with the suction head, the cost of the suction head quantity that has significantly reduced has avoided the pollution that the suction head caused the environment.
Drawings
Fig. 1 is a front view of a 2-well capillary pipetting device provided in this example.
Fig. 2 is a perspective view of the 2-well capillary pipetting device provided in this embodiment.
FIG. 3 is a perspective view of a 96-well capillary pipetting device provided in this example and having a boss.
Fig. 4 is a perspective view of an observation panel of the 96-well capillary pipetting device provided in this embodiment.
FIG. 5 is a perspective view of a 96-well capillary pipetting device in which the capillary provided in this embodiment is in the shape of a circular truncated cone.
FIG. 6 is a perspective view of a 96-well capillary pipetting device provided in this example without a boss.
100-a panel; 200-holes; 300-a capillary tube; 400-boss; 500-bump; 600-scale.
Detailed Description
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
The application the capillary be the tubule, its internal diameter is less, when liquid is in the pipe, because the difference of cohesion and adhesive force, liquid can overcome gravity and rise, produces the capillary phenomenon.
Example 1, 2 well capillary pipetting device
As shown in fig. 1 and 2, the present embodiment provides a 2-well capillary pipetting device, which comprises a panel 100, wherein 2 identical wells 200 are opened on the panel 100, and each well 200 extends downward to form a capillary 300. The outer diameter of the capillary tube 300 is smaller than the inner diameter of the EP centrifuge tube, and the capillary tube 300 may be provided with a scale 600.
The procedure for transferring liquid using a 2-well capillary pipetting device is as follows: the capillary 300 of the capillary liquid-transfering device with 2 holes is vertically extended into the enzyme liquid to be transferred, the liquid to be transferred is sucked into the capillary liquid-transfering device along the tube wall of the capillary 300 by means of capillary action, and the enzyme liquid in the capillary liquid-transfering device is transferred into an EP centrifugal tube by means of the force of hand throwing.
Example 2, 96-well capillary pipetting device (with Boss)
In this example, a 96-well capillary pipetting device (including a well plate) adapted to a 96-well plate of 200. mu. l V type bottom is described as an example.
As shown in fig. 3 and 4, the capillary pipetting device in the present embodiment is a 96-well capillary pipetting device adapted to a 96-well plate of type 200 μ l V bottom.
The 96-well capillary pipetting device comprises a panel 100, 96 identical wells 200 are formed in the panel 100, and each well 200 extends downward to form a capillary 300. A boss 400 is provided at a contact portion of the face plate 100 and the capillary 300 to restrict the capillary 300 from shaking and contacting a hole wall of the 96-well plate. The capillary 300 has an outer diameter of 4mm, an inner diameter of 2mm, a height of 13.5mm, about 2/3 times the depth of the hole of a 96-well plate, and a scale 600 marked on the outer wall.
Method of use of 96-well capillary pipetting device: the capillary 300 of the 96-hole capillary liquid-transfering device is vertically extended into the page of the liquid to be transferred, the liquid in the capillary is lifted up along the tube wall due to the capillary action, and the volume of the liquid in the capillary is read when the liquid is stable. The 96-well capillary pipetting device was then inserted vertically into the wells of the 96-well plate, and the 96-well plate covered with the 96-well capillary pipetting device was centrifuged. During centrifugation (generally only 30 s), the liquid is thrown out of the capillary by centrifugal force and transferred to the wells of a 96-well plate.
In this embodiment, the shape and size of the panel 100 are not limited. To facilitate centrifugation, the shape and size of the panel 100 of the 96-well capillary pipetting device is the same as the panel of the 96-well plate or the panel 100 of the 96-well capillary pipetting device is smaller than the panel of the 96-well plate; in order to facilitate the separation of the capillary pipetting device from the multiwell plate, a member capable of facilitating the separation of the two devices in the related art, such as a pull ring or the like, may be provided on the panel 100; to facilitate the handling and placing of the 96-well capillary pipetting device, projections may be provided on the edge or the middle portion of the panel 100, or grooves may be provided on the edge portion of the panel 100, or the like.
As shown in fig. 4, in the present embodiment, fixing protrusions 500 are respectively disposed at four corners of the panel 100, so as to limit sliding of an article placed on the panel 100.
In order to adapt to the V-bottom 96-well plate and prevent the capillary 300 from shaking or breaking the coating on the wall of the 96-well plate, the capillary 300 may be formed in a truncated cone shape as shown in fig. 5 in this embodiment. The maximum outer diameter of the circular truncated cone-shaped capillary 300 is the same as the diameter of the opening of the hole of the 96-well plate, and the minimum outer diameter of the circular truncated cone is smaller than the inner diameter of the hole of the 96-well plate corresponding to the height of the minimum outer diameter of the circular truncated cone when the 96-well capillary pipetting device is placed in the 96-well plate.
Example 3, 96-well capillary pipetting device
In this example, a 96-well capillary pipetting device (not including a boss) adapted to a 200. mu. l V type bottom 96-well plate is also described as an example.
As shown in fig. 6, the capillary pipetting device in this embodiment is a 96-well capillary pipetting device adapted to a 96-well plate of type 200 μ l V.
In this example, the capillary 300 has an outer diameter of 5mm, an inner diameter of 2.5mm, a height of 8mm, and a depth of about 1/3 mm of the wells of a 96-well plate.
In this embodiment, the height of the capillary 300 is 8mm, and when the capillary 300 extends into the 96-well plate, the bottom edge of the capillary 300 is just clamped at the middle upper part of the inner wall of the 96-well plate (the contact part is far from the bottom of the 96-well plate, and no coating is formed at the contact part), so that the capillary 300 is prevented from shaking in the 96-well plate. The height of the capillary 300 in this embodiment may be designed to be greater than 8mm, for example, the height of the capillary 300 is 10mm, so that when the capillary 300 extends into the well of the 96-well plate, the panel 100 is at a certain distance from the panel of the 96-well plate, which facilitates the separation of the 96-well capillary pipetting device from the 96-well plate. This example 96-well capillary pipetting device was used in the same manner as in example 2.
In conclusion, the capillary liquid-transfering device that this application provided, it utilizes capillary principle to absorb liquid, compares in the mode of the absorption liquid of pipettor cooperation suction head, and the error of the volume that the capillary absorbed liquid obviously reduces, especially to parallel test, and error between each other reduces for the experimental result is more accurate. Porous capillary liquid-transfering device with perforated plate adaptation is used, for example, 96 hole capillary liquid-transfering device with 96 hole board adaptation is used, can once only carry out 96 hole's liquid-transfering operation, need not use pipettor suction head, when can avoiding handheld pipettor, because of hand shake or the destruction of the pipettor that is caused by the collision on the perforated plate pore wall, or to the pollution overall process easy and simple to handle of hole bottom reactant/liquid, degree of automation is high, consuming time is short, the disposable liquid-transfering operation that carries out 96 hole only need get liquid once, in addition 30s centrifugation can be accomplished, be particularly useful for the rinsing to 96 hole board, elution etc. The 96-hole capillary liquid transfer device can be used as a liquid transfer device, can be recycled, can be prepared from materials such as high-temperature-resistant metal and polypropylene according to the requirements during use, for example, aseptic operation is required, and can be directly sterilized before use. The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.
Claims (10)
1. The capillary pipet is characterized by comprising a panel (100), wherein at least 1 same hole (200) is formed in the panel (100), and each hole (200) extends downwards to form a capillary (300).
2. Capillary pipetting device according to claim 1, characterized in that the capillary pipetting device is adapted to a multi-well plate for transferring liquid simultaneously to more than two wells in the multi-well plate at a time.
3. Capillary pipetting device according to claim 2, characterized in that the multi-well plate is a 4-well plate, a 6-well plate, an 8-well plate, a 12-well plate, a 24-well plate, a 48-well plate, a 96-well plate or a 384-well plate.
4. Capillary pipetting device according to claim 2, characterized in that the outer diameter of the capillary (300) is smaller than the inner diameter of the well of the multiwell plate.
5. Capillary pipetting device according to claim 2, characterized in that the height of the capillary (300) is 1/3-2/3 of the depth of the well of the multiwell plate.
6. Capillary pipetting device according to claim 1, characterized in that the capillary (300) is provided with scale symbols (600).
7. Capillary pipetting device according to claim 1, characterized in that the contact part of the panel (100) with the capillary (300) is provided with a boss (400).
8. Capillary pipetting device according to claim 1, characterized in that the inner diameter of the capillary is ≤ 2.5 mm.
9. Capillary pipetting device according to any one of claims 1-8, characterized in that the capillary pipetting device is made of a material selected from the group consisting of metallic or polymeric materials.
10. A mold for manufacturing a capillary pipetting device according to any one of claims 1 to 9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110251265.9A CN112934286A (en) | 2021-03-08 | 2021-03-08 | Capillary tube liquid-transfering device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110251265.9A CN112934286A (en) | 2021-03-08 | 2021-03-08 | Capillary tube liquid-transfering device |
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| CN112934286A true CN112934286A (en) | 2021-06-11 |
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| CN202110251265.9A Pending CN112934286A (en) | 2021-03-08 | 2021-03-08 | Capillary tube liquid-transfering device |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103394380A (en) * | 2013-07-31 | 2013-11-20 | 中国科学院上海微系统与信息技术研究所 | High-flux trace liquid sample distribution device and use method |
| CN207223346U (en) * | 2017-09-30 | 2018-04-13 | 宁波市锦泰橡塑有限公司 | A kind of capillary tube member dismounting instrument easy to use |
| CN108273454A (en) * | 2016-12-27 | 2018-07-13 | 中国科学院微生物研究所 | A kind of method that nanoliter level microlayer model merges in small-sized reaction tube |
| CN211066540U (en) * | 2019-10-23 | 2020-07-24 | 天津市人民医院 | Tear stability detection device |
| CN111468312A (en) * | 2020-05-28 | 2020-07-31 | 深圳泌码科技有限公司 | Perforated plate liquid collecting device adaptive to centrifugal machine and application thereof |
| CN214716756U (en) * | 2021-03-08 | 2021-11-16 | 深圳泌码科技有限公司 | Capillary tube liquid transfer device and die thereof |
-
2021
- 2021-03-08 CN CN202110251265.9A patent/CN112934286A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103394380A (en) * | 2013-07-31 | 2013-11-20 | 中国科学院上海微系统与信息技术研究所 | High-flux trace liquid sample distribution device and use method |
| CN108273454A (en) * | 2016-12-27 | 2018-07-13 | 中国科学院微生物研究所 | A kind of method that nanoliter level microlayer model merges in small-sized reaction tube |
| CN207223346U (en) * | 2017-09-30 | 2018-04-13 | 宁波市锦泰橡塑有限公司 | A kind of capillary tube member dismounting instrument easy to use |
| CN211066540U (en) * | 2019-10-23 | 2020-07-24 | 天津市人民医院 | Tear stability detection device |
| CN111468312A (en) * | 2020-05-28 | 2020-07-31 | 深圳泌码科技有限公司 | Perforated plate liquid collecting device adaptive to centrifugal machine and application thereof |
| CN214716756U (en) * | 2021-03-08 | 2021-11-16 | 深圳泌码科技有限公司 | Capillary tube liquid transfer device and die thereof |
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Effective date of registration: 20240307 Address after: 200000 Building 1, No.1 Haikun Road, Fengxian District, Shanghai Applicant after: Shanghai Mima Life Science Co.,Ltd. Country or region after: China Address before: 518000 room 1701, building B2, block B, phase I, Baoneng science and Technology Park (South District), Qinghu Industrial Zone, Gangtou community, Bantian street, Longgang District, Shenzhen City, Guangdong Province Applicant before: Shenzhen Bi Code Technology Co.,Ltd. Country or region before: China |