CN112914782A - Continuous micro-perfusion catheter for esophageal mucosa - Google Patents

Abstract

The invention discloses an esophageal mucosa continuous micro perfusion catheter which comprises an outer sheath tube and an inner core tube, wherein the outer sheath tube is provided with a penetrating channel, the inner core tube is a flexible tube and penetrates through the penetrating channel, the far end of the inner core tube protrudes out of the far end of the outer sheath tube, the near end of the inner core tube protrudes out of the near end of the outer sheath tube, the inner core tube can move relative to the outer sheath tube to adjust the length of the inner core tube protruding out of the outer sheath tube, the far end of the inner core tube is of a closed structure, the far end of the inner core tube is provided with a plurality of perfusion holes, and the plurality of perfusion holes are arranged at intervals along the circumferential direction of the inner core tube. Because the inner core pipe is the flexible tube, can effectively adapt to the esophagus at the in-process that the inner core pipe removed along the esophagus, avoid causing the damage to the esophagus, in addition, utilize a plurality of perfusion holes that form on the lateral wall of inner core pipe distal end, can effectively guarantee to coat the liquid medicine on the esophagus wall to guarantee the accuracy of experiment.

Description

Continuous micro-perfusion catheter for esophageal mucosa

Technical Field

The invention relates to the technical field of medical instruments, in particular to an esophageal mucosa continuous micro perfusion catheter.

Background

This section provides background information related to the present disclosure only and is not necessarily prior art.

In the continuous micro-stimulation experiment of the esophageal mucosa of small animals (such as young rats, mice and the like), the continuous micro-stimulation experiment is generally completed by using a cannula instrument.

Among the prior art, the intubate utensil is the gavage needle usually, there are many drawbacks in the gavage needle (the gavage needle is stainless steel material or PTFE (polytetrafluoroethylene) material usually, stainless steel material's gavage needle has certain hardness, can not bend, can't satisfy effectively to adapt to the esophagus, the gavage needle of PTFE material is though can be crooked in certain extent, but because the tensile existence of bending, the position that leads to the gavage needle easily changes or damages the esophagus, in addition, the gavage needle only has an opening along the axis of ordinates, the direction of filling can only be along the axis of ordinates direction of gavage needle, can't make the esophagus wall peripherial mucous membrane coating chemical preparation), can't effectively satisfy the user demand.

Disclosure of Invention

The invention aims to at least solve the problem that the existing intubation instrument cannot effectively meet the use requirement. The purpose is realized by the following technical scheme:

the invention provides an esophageal mucosa continuous micro perfusion catheter, which comprises:

the outer sheath tube is provided with a through channel;

inner core pipe, inner core pipe is the flexible tube and wears to locate wear to establish in the passageway, inner core pipe's distal end protrusion in outer sheath pipe's distal end, inner core pipe's proximal end protrusion in outer sheath pipe's proximal end, inner core pipe can be relative outer sheath pipe removes, in order to adjust inner core pipe protrusion in outer sheath pipe's length, inner core pipe's distal end is the enclosed construction, and inner core pipe's distal end is equipped with a plurality of filling holes, and is a plurality of filling hole is followed inner core pipe's circumference interval sets up.

According to the continuous micro perfusion catheter for the esophageal mucosa, when an experiment is carried out by utilizing the continuous micro perfusion catheter for the esophageal mucosa, the inner core tube is moved, the far end of the inner core tube is enabled to be close to the far end of the outer sheath tube (the far end of the inner core tube is located on the outer side of the far end of the outer sheath tube), the far end of the outer sheath tube is inserted into the esophagus of a small animal, the near end of the outer sheath tube is arranged on the outer side of the esophagus of the small animal, external force acts on the inner core tube, the far end of the inner core tube moves towards the direction far away from the far end of the outer sheath tube until the far end of the inner core tube reaches the experiment position, the inner core tube is fixed with the outer sheath tube, the position of the outer sheath tube is fixed, the near end of the inner core tube is connected with a liquid medicine supply device (an injector or an injection pump and the like), the liquid medicine is sent into the inner core tube by the liquid medicine supply device, the liquid medicine flows to the, so as to make the liquid medicine spread on the esophagus wall. Because the inner core pipe is the flexible tube, can effectively adapt to the esophagus at the in-process that the inner core pipe removed along the esophagus, avoid causing the damage to the esophagus, in addition, utilize a plurality of perfusion holes that form on the lateral wall of inner core pipe distal end, can effectively guarantee to coat the liquid medicine on the esophagus wall to guarantee the accuracy of experiment.

In addition, the esophageal mucosa continuous micro-perfusion catheter according to the invention can also have the following additional technical characteristics:

in some embodiments of the present invention, the distal end of the outer sheath is provided with a protective structure, and the protective structure is an ellipsoidal structure.

In some embodiments of the invention, the distal end of the ellipsoidal structure is provided with a via hole through which the inner core tube passes.

In some embodiments of the present invention, the sealing structure is a silica gel, and an outer surface of the silica gel is disposed in an arc shape.

In some embodiments of the invention, the inner core tube has an inner diameter of 0.011mm to 0.28 mm;

and/or the outer diameter of the inner core pipe is 0.024 mm-0.61 mm;

and/or the length of the inner core tube is 3 m-30 m.

In some embodiments of the present invention, the inner core tube is provided with a first continuous scale along the length direction thereof, and the interval between two adjacent scales of the first continuous scale is 1 cm.

In some embodiments of the invention, the inner diameter of the outer sheath is 0.50mm to 0.68 mm;

and/or the outer diameter of the outer sheath tube is 0.90 mm-1.18 mm;

and/or the length of the sheath tube is 3 cm-10 cm.

In some embodiments of the present invention, the outer sheath tube is provided with a second continuous scale along the length direction thereof, and the interval between two adjacent scales of the second continuous scale is 1 cm.

In some embodiments of the present invention, the esophageal mucosa continuous micro perfusion catheter further includes a fastener having a through hole, the fastener is disposed at the proximal end of the outer sheath tube, the inner core tube is disposed through the through hole, and the fastener can cooperate with the outer sheath tube to fix the inner core tube or release the fixation of the inner core tube.

In some embodiments of the invention, the fastener comprises:

a manipulation part driven by an external force;

the thread part, screw thread part coaxial coupling in control the portion, the through-hole run through in screw thread part with control the portion, screw thread part with the screw interface threaded connection of the near end of sheath pipe, screw thread part with the screw interface state of screwing, the inner core pipe is fixed, screw thread part with the screw interface state of unscrewing, the inner core pipe is released fixedly.

Drawings

Various other advantages and benefits will become apparent to those of ordinary skill in the art upon reading the following detailed description of the preferred embodiments. The drawings are only for purposes of illustrating the preferred embodiments and are not to be construed as limiting the invention. Also, like parts are designated by like reference numerals throughout the drawings. In the drawings:

fig. 1 schematically shows a structural view of an esophageal mucosa continuous micro-perfusion catheter according to an embodiment of the present invention;

fig. 2 is a schematic exploded view of the esophageal mucosa continuous micro-perfusion catheter shown in fig. 1.

The reference numbers are as follows:

100 is a continuous micro-perfusion catheter for esophageal mucosa;

10 is an external sheath;

11 is a protective structure, and 12 is a threaded interface;

20 is an inner core tube;

21 is a closed structure, and 22 is a perfusion hole;

30 is a fastener;

31 is a control part, and 32 is a thread part.

Detailed Description

Exemplary embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. While exemplary embodiments of the present disclosure are shown in the drawings, it should be understood that the present disclosure may be embodied in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art.

It is to be understood that the terminology used herein is for the purpose of describing particular example embodiments only, and is not intended to be limiting. As used herein, the singular forms "a", "an" and "the" may be intended to include the plural forms as well, unless the context clearly indicates otherwise. The terms "comprises," "comprising," "including," and "having" are inclusive and therefore specify the presence of stated features, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, steps, operations, elements, components, and/or groups thereof. The method steps, processes, and operations described herein are not to be construed as necessarily requiring their performance in the particular order described or illustrated, unless specifically identified as an order of performance. It should also be understood that additional or alternative steps may be used.

Although the terms first, second, third, etc. may be used herein to describe various elements, components, regions, layers and/or sections, these elements, components, regions, layers and/or sections should not be limited by these terms. These terms may be only used to distinguish one element, component, region, layer or section from another region, layer or section. Terms such as "first," "second," and other numerical terms when used herein do not imply a sequence or order unless clearly indicated by the context. Thus, a first element, component, region, layer or section discussed below could be termed a second element, component, region, layer or section without departing from the teachings of the example embodiments.

For convenience of description, spatially relative terms, such as "inner", "outer", "lower", "below", "upper", "above", and the like, may be used herein to describe one element or feature's relationship to another element or feature as illustrated in the figures. Such spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as "below" or "beneath" other elements or features would then be oriented "above" or "over" the other elements or features. Thus, the example term "below … …" can include both an orientation of above and below. The device may be otherwise oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.

As shown in fig. 1 and 2, according to an embodiment of the present invention, an esophageal mucosa continuous micro perfusion catheter 100 is provided, the esophageal mucosa continuous micro perfusion catheter 100 includes an outer sheath tube 10 and an inner core tube 20, the outer sheath tube 10 is provided with a through channel, the inner core tube 20 is a flexible tube and is arranged in the through channel, a distal end of the inner core tube 20 protrudes out of a distal end of the outer sheath tube 10, a proximal end of the inner core tube 20 protrudes out of a proximal end of the outer sheath tube 10, the inner core tube 20 is capable of moving relative to the outer sheath tube 10 to adjust a length of the inner core tube 20 protruding out of the outer sheath tube 10, a distal end of the inner core tube 20 is a closed structure 21, and a distal end of the inner core tube 20 is provided with a plurality of perfusion holes 22, the plurality of perfusion holes 22 are arranged at intervals along a circumferential direction of the inner core tube.

Specifically, when an experiment is performed by using the esophageal mucosa continuous micro perfusion catheter 100, the inner core tube 20 is moved so that the distal end of the inner core tube 20 is disposed close to the distal end of the outer sheath tube 10 (the distal end of the inner core tube 20 is disposed outside the distal end of the outer sheath tube 10), the distal end of the outer sheath tube 10 is inserted into the esophagus of a small animal, the proximal end of the outer sheath tube 10 is disposed outside the esophagus of the small animal, an external force acts on the inner core tube 20 so that the distal end of the inner core tube 20 moves in a direction away from the distal end of the outer sheath tube 10 until the distal end of the inner core tube 20 reaches the experimental position, the inner core tube 20 is fixed to the outer sheath tube 10, the position of the outer sheath tube 10 is fixed, the proximal end of the inner core tube 20 is connected to a liquid medicine supply device (a syringe, an injection pump, or the like), the liquid medicine supply device sends the liquid medicine into the inner core tube 20, and the, and is applied to the esophageal wall of the small animal through the irrigation hole 22 at the distal end of the inner core tube 20 to apply the medical solution to the esophageal wall. Because the inner core pipe 20 is the flexible pipe, can effectively adapt to the esophagus at the in-process that the inner core pipe 20 removed along the esophagus, avoid causing the damage to the esophagus, in addition, utilize a plurality of perfusion holes 22 that form on the lateral wall at the inner core pipe 20 distal end, can effectively guarantee to coat the liquid medicine on the esophagus wall to guarantee the accuracy of experiment.

It is to be understood that in this application proximal refers to the end inserted inside the esophagus and distal refers to the end located outside the esophagus.

In addition, the inner core tube 20 is a flexible tube, which has high flexibility and can effectively adapt to the esophagus, thereby avoiding damage to the esophagus, and meanwhile, the length of the inner core tube 20 is not limited, and the coating position of the liquid medicine can be adjusted by adjusting the length of the inner core tube 20.

In addition, because a plurality of infusion holes 22 set up along the circumference of inner core pipe 20, when the liquid medicine was spout through each infusion hole 22, the liquid medicine can be sprayed to the outside through the circumference of inner core pipe 20 to avoided among the prior art, only carried out the axial through the gavage needle and sprayed, made the esophagus wall can be by even coating, thereby guaranteed the effect of experiment.

It should be noted that, the outer sheath tube 10 is made of PTFE (that is, the outer sheath tube 10 is a PTFE member), the inner core tube 20 is made of PE (polyethylene), the hardness of the outer sheath tube 10 is greater than that of the inner core tube 20, when the esophageal mucosa continuous micro perfusion catheter 100 is used for an experiment, the outer sheath tube 10 carries the inner core tube 20 to be synchronously inserted into the esophagus of a small animal, and the proximal end of the outer sheath tube 10 is located outside the body of the small animal, at this time, because the outer sheath tube 10 is made of PTFE, the outer sheath tube has a certain hardness, it is ensured that the intubation process is smooth and does not bend, the inner core tube 20 moves relative to the penetration channel of the outer sheath tube 10, so that the distal end of the inner core tube 20 reaches a preset position, the inner core tube 20 is made of PE, and the flexibility is good, so that the esophagus is not damaged in the process of the movement of the inner core tube 20.

In addition, the inner core tube 20 is a flexible tube and can be set to a sufficient length to be connected and fixed with a commercially available syringe injection needle, and the inner core tube is placed in a micro-perfusion pump to perform continuous perfusion of esophageal mucosa, so that various speed requirements can be met.

In addition, a plurality of infusion holes 22 are arranged at equal intervals along the circumference of the inner core tube 20, so that the liquid medicine can be uniformly coated on the inner wall of the esophagus after passing through each infusion hole 22, and the experimental effect is ensured.

Further, the distal end of the outer sheath tube 10 is provided with a protective structure 11, and the protective structure 11 is an ellipsoidal structure. Specifically, the distal end of sheath pipe 10 is provided with protective structure 11 for the ellipsoidal structure, and when using esophagus mucous membrane to last micro-perfusion catheter 100 and experiment, the distal end of doing inserts in the esophagus of toy, sets up protective structure 11 through the distal end with sheath pipe 10, sets up protective structure 11 for the ellipsoidal structure simultaneously to avoid producing the scraping at the intubate in-process to the esophagus, avoided the harm that causes the esophagus.

It should be understood that the surface of the ellipsoidal structure is smooth, so that in the process of inserting into the esophagus, the friction between the ellipsoidal structure and the esophageal wall can be reduced, the smoothness of the insertion process is improved, and the situation that the far end of the sheath tube 10 is stuck with the esophageal wall is avoided, so as to avoid damage to the esophagus.

It should be pointed out that, the connection position of the ellipsoidal structure and the distal end of the outer sheath tube 10 is smooth transition, which avoids the adverse effect on the esophageal wall caused by the appearance of a sharp device structure at the connection position, in addition, the protective structure 11 of the ellipsoidal structure can be integrated with the outer sheath tube 10, or can be a split structure with the outer sheath tube 10, when the two are integrated, the two are manufactured and molded integrally, so as to reduce the manufacturing cost, when the two are split structures, the two are manufactured respectively, and are connected and fixed in a welding or bonding manner, thereby reducing the difficulty of processing and manufacturing.

In addition, the major axis of the ellipsoidal structure is consistent with the axial direction of the outer sheath 10, the end of the ellipsoidal structure is consistent with the radial direction of the outer sheath 10, and the minor axis radius of the ellipsoidal structure is greater than the radius of the outer sheath 10, that is, the ellipsoidal structure is arranged at the distal end of the outer sheath 10 to protrude to the radial outer side of the outer sheath 10, so that the outer sheath 10 is prevented from contacting with the esophageal wall in the process of being inserted into the esophagus, and the esophagus is further prevented from being damaged.

Further, the far end of the ellipsoidal structure is provided with a via hole for the inner core tube 20 to penetrate through. Specifically, a penetrating channel in the outer sheath tube 10 is communicated with the outside through a via hole, the inner core tube 20 is penetrated in the penetrating channel, the proximal end of the inner core tube 20 penetrates out through the proximal end of the outer sheath tube 10, the distal end of the inner core tube 20 penetrates out through the via hole, when a small animal is intubated, the position of the inner core tube 20 relative to the penetrating channel is adjusted, so that the distal end of the inner core tube 20 is arranged close to the distal end of the outer sheath tube 10 (at this time, the distal end of the inner core tube 20 is positioned at the outer side of the distal end of the outer sheath tube 10), the distal end of the outer sheath tube 10 and the distal end of the inner core tube 20 are inserted into the esophagus of the small animal, after the outer sheath tube 10 is inserted in place, the inner core tube 20 is driven to move relative to the penetrating channel, so that the distal end of the inner core tube 20 continues to move to the position of the esophagus to be tested, when the inner core tube 20, the liquid medicine is injected into the esophagus through the liquid medicine supply device, so that the smooth operation of the experiment is ensured.

It should be noted that the through channel is coaxial with the outer sheath tube 10, and the through hole is coaxial with the through channel, so as to ensure that the inner core tube 20 and the outer sheath tube 10 are coaxial, and further ensure the coaxiality of the inner core tube 20 and the outer sheath tube 10.

In addition, the diameter of the through hole is slightly larger than the outer diameter of the inner core tube 20, so that the gap between the through hole and the inner core tube 20 is smaller, and liquid in the esophagus is prevented from entering the outer sheath tube 10 through the through hole.

Further, the closed structure 21 is silica gel, and the outer surface of the silica gel is arranged in an arc shape. Specifically, the distal end of inner core pipe 20 is sealed by enclosed construction 21, and this enclosed construction 21 is silica gel, seals the distal end of inner core pipe 20 through silica gel promptly, and a plurality of infusion holes 22 are close to enclosed construction 21 and set up to a plurality of infusion holes 22 are along the equidistant setting of circumference of inner core pipe 20, through sealing the distal end of inner core pipe 20, thereby make the distal end mouth that the liquid medicine reachd inner core pipe 20 can only spout through a plurality of infusion holes 22 of inner core pipe 20, thereby guaranteed that the liquid medicine can evenly coat on the esophagus wall, in order to improve the peripherical coating effect to the esophagus wall. In addition, the outer surface of the silica gel is set to be arc-shaped, and the arc-shaped is a graph arc-shaped, so that the scraping to the esophagus wall in the process that the inner core tube 20 moves in the esophagus is avoided, and the injury to the esophagus is avoided.

It should be noted that the closed structure 21 is also an ellipsoid-shaped structure, which further avoids scraping the esophageal wall, so that the esophagus is protected from being damaged.

Further, the inner diameter of the inner core tube 20 is 0.011mm to 0.28 mm. Specifically, by setting the inner diameter of the inner core tube 20 to be in the range of 0.011mm to 0.28mm, it is possible to ensure good permeability of the chemical liquid, and the supply amount of the chemical liquid can be sufficiently ensured.

Specifically, the outer diameter of the inner core tube 20 is 0.024mm to 0.61 mm. Specifically, the outer diameter of the inner core tube 20 is set to be in the range of 0.024 mm-0.61 mm, so that the inner core tube 20 is more suitable for the esophagus of small animals, and the inner core tube 20 is ensured to have good passing performance in the esophagus, so that the esophagus is prevented from being damaged.

Specifically, the length of the inner core tube 20 is 3m to 30 m. The length of the inner core tube 20 is set to be 3 m-30 m, so that the inner core tube is effectively connected with the liquid medicine supply device, the liquid medicine can be continuously supplied, and the experiment can be effectively carried out.

Further, the inner core tube 20 is provided with a first continuous scale along the length direction thereof, and the interval between two adjacent scales of the first continuous scale is 1 cm. Specifically, the first continuous scale is arranged on the inner core tube 20, and when the position of the inner core tube 20 is adjusted, the position of the inner core tube 20 can be controlled by observing the first continuous scale of the inner core tube 20, so that the precision of the experiment is improved, and the effect of the experiment is ensured. In addition, the distance between the two scales is set to be 1cm, so that the control precision of the position of the inner core tube 20 is further improved, the spraying position of the liquid medicine is ensured, and the experimental effect is further improved.

Further, the inner diameter of the outer sheath tube 10 is 0.50mm to 0.68 mm. Specifically, the inner diameter of the sheath tube 10 is set to be in the range of 0.50mm to 0.68mm, that is, the diameter of the through channel is set to be 0.50mm to 0.68mm, so that the inner core tube 20 is ensured to have good trafficability in the through channel, and the inner core tube 20 is ensured to be effectively adjusted.

Specifically, the outer sheath tube 10 has an outer diameter of 0.90mm to 1.18 mm. The outer diameter of the outer sheath tube 10 is set in the range of 0.90 mm-1.18 mm, so that the outer sheath tube 10 is more suitable for the esophagus of small animals, the inner core tube 20 is ensured to have good trafficability in the esophagus, and the esophagus is prevented from being damaged.

Specifically, the length of the outer sheath tube 10 is 3cm to 10 cm. The length of the outer sheath tube 10 is set to be 3 cm-10 cm, so that the support of the outer sheath tube 10 and the inner core tube 20 is guaranteed, the inner core tube 20 can effectively enter the esophagus and reach the experimental position in the esophagus, and the liquid medicine can effectively reach the experimental position to guarantee the smooth operation of the experiment.

Further, the outer sheath tube 10 is provided with a second continuous scale along the length direction thereof, and the interval between two adjacent scales of the second continuous scale is 1 cm. Specifically, set up the continuous scale of second on sheath pipe 10, when carrying out the intubate to the toy, can realize the control to sheath pipe 10 position through the continuous scale of second of observing sheath pipe 10 to the precision of experiment has been improved, makes the effect of experiment obtain the assurance. In addition, the distance between the two scales is set to be 1cm, so that the control precision of the position of the sheath tube 10 is further improved, and the experimental effect is improved.

Further, the esophageal mucosa continuous micro-perfusion catheter 100 further comprises a fastener 30 with a through hole, the fastener 30 is arranged at the proximal end of the outer sheath tube 10, the inner core tube 20 is arranged through the through hole, and the fastener 30 can be matched with the outer sheath tube 10 to fix the inner core tube 20 or release the fixation of the inner core tube 20. Specifically, when the small animal is intubated, the position of the inner core tube 20 relative to the through passage is adjusted, so that the distal end of the inner core tube 20 is disposed close to the distal end of the outer sheath tube 10 (in this case, the distal end of the inner core tube 20 is located outside the distal end of the outer sheath tube 10), the fastener 30 fixes the position of the inner core tube 20, the distal end of the outer sheath tube 10 and the distal end of the inner core tube 20 are inserted into the esophagus of the small animal, after the sheath tube 10 is inserted in place, the fastener 30 is loosened, the inner core tube 20 is driven to move relatively to the through passage, so that the distal end of the inner core tube 20 moves continuously to the position of the esophagus to be tested, when the inner core tube 20 reaches the preset experimental position, the position of the inner core tube 20 is fixed by the fastener 30, and then the outer sheath tube 10 is fixed, in addition, the inner core tube 20 is connected to a chemical liquid supply device, and a chemical liquid is injected into the esophagus through the chemical liquid supply device, thereby ensuring smooth progress of an experiment. Through setting up fastener 30 to realized keeping inner core pipe 20 position, further guaranteed the precision of liquid medicine injection position, made the effect of experiment obtain guaranteeing effectively.

Further, the fastener 30 includes: the manipulation part 31 and the screw part 32, the manipulation part 31 is driven by external force, the screw part 32 is coaxially connected to the manipulation part 31, the through hole penetrates through the screw part 32 and the manipulation part 31, the screw part 32 is in threaded connection with the screw interface 12 at the proximal end of the outer sheath 10, the screw part 32 is in a screwed state with the screw interface 12, the inner core tube 20 is fixed, the screw part 32 is in a unscrewed state with the screw interface 12, and the inner core tube 20 is released from being fixed. Specifically, the threaded interface 12 is provided at the proximal end of the outer sheath tube 10, the threaded portion 32 of the fastener 30 is threadedly coupled to the threaded interface 12, the inner core tube 20 is disposed through the fastener 30, when it is necessary to release the restriction with the inner core tube 20, the threaded portion 32 is unscrewed from the threaded interface 12, the inner core tube 20 can move relative to the fastener 30, and when it is necessary to fix the inner core tube 20, the threaded portion 32 is screwed to the threaded interface 12, thereby fixing the inner core tube 20. The fastener 30 is simple in structure, convenient to control and capable of effectively improving convenience of operation, in addition, the fastener 30 is high in fixing strength and good in stability, the position of the inner core pipe 20 is effectively kept, and accuracy of an experiment is improved.

It should be noted that the screw interface 12 is a tapered structure, the screw portion 32 is divided into a plurality of movable structures, the inner core tube 20 passes through the axial position of the fastening member 30, when the screw portion 32 is screwed with respect to the screw interface 12, each movable structure moves toward the axial position of the fastening member 30 and abuts against the outer surface of the inner core tube 20 to fix the inner core tube 20, and when the screw portion 32 is unscrewed with respect to the interface, each movable structure moves in the axial direction away from the fastening member 30, each movable structure is separated from the inner core tube 20, so that the fixation of the inner core tube 20 is released.

In addition, the esophageal mucosa continuous micro perfusion catheter 100 further comprises an illumination assembly and a video acquisition assembly, the illumination assembly comprises an illuminating lamp, a power line, a switch and a power supply, the video acquisition assembly comprises a camera, a signal line and a display screen, wherein the switch and the power supply are arranged at the near end (can be provided with a shell) of the inner sheath tube, the illuminating lamp is arranged at the far end of the inner sheath tube and is positioned in the tube wall of the inner core tube 20, the illuminating lamp is connected with a power supply of a switching device through the power line, the camera is arranged at the far end of the inner sheath tube, the video line is arranged in the tube wall of the inner core tube 20, the camera is electrically connected with the display screen through the video line (can be provided with an independent power supply), when a small animal is subjected to an intubation experiment, the switch is closed, the camera lamp is lightened, the experiment position is subjected to image acquisition, and, the precision and the accuracy of the experiment are further ensured.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are included in the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims (10)

1. An esophageal mucosa continuous micro-perfusion catheter, characterized in that it comprises:

the outer sheath tube is provided with a through channel;

inner core pipe, inner core pipe is the flexible tube and wears to locate wear to establish in the passageway, inner core pipe's distal end protrusion in outer sheath pipe's distal end, inner core pipe's proximal end protrusion in outer sheath pipe's proximal end, inner core pipe can be relative outer sheath pipe removes, in order to adjust inner core pipe protrusion in outer sheath pipe's length, inner core pipe's distal end is the enclosed construction, and inner core pipe's distal end is equipped with a plurality of filling holes, and is a plurality of filling hole is followed inner core pipe's circumference interval sets up.

2. The esophageal mucosal continuous micro-perfusion catheter as claimed in claim 1, wherein the distal end of the sheath is provided with a protective structure, and the protective structure is an ellipsoidal structure.

3. The esophageal mucosa continuous micro-perfusion catheter as claimed in claim 2, wherein the distal end of the ellipsoidal structure is provided with a through hole for the core tube to pass through.

4. The esophageal mucosa continuous micro-perfusion catheter as claimed in claim 1, wherein the sealing structure is silica gel, and the outer surface of the silica gel is arc-shaped.

5. The esophageal mucosa continuous micro-perfusion catheter as claimed in claim 1, wherein the inner diameter of the inner core tube is 0.011mm to 0.28 mm;

and/or the outer diameter of the inner core pipe is 0.024 mm-0.61 mm;

and/or the length of the inner core tube is 3 m-30 m.

6. The esophageal mucosa continuous micro-perfusion catheter as claimed in claim 5, wherein the inner core tube is provided with a first continuous scale along the length direction, and the interval between two adjacent scales of the first continuous scale is 1 cm.

7. The esophageal mucosa continuous micro-perfusion catheter as claimed in claim 1, wherein the inner diameter of the outer sheath is 0.50mm to 0.68 mm;

and/or the outer diameter of the outer sheath tube is 0.90 mm-1.18 mm;

and/or the length of the sheath tube is 3 cm-10 cm.

8. The esophageal mucosa continuous micro-perfusion catheter as claimed in claim 7, wherein the outer sheath is provided with a second continuous scale along the length direction, and the interval between two adjacent scales of the second continuous scale is 1 cm.

9. The esophageal mucosa continuous micro-perfusion catheter as claimed in any one of claims 1 to 8, further comprising a fastener having a through hole, wherein the fastener is disposed at the proximal end of the outer sheath tube, the inner core tube is disposed through the through hole, and the fastener can cooperate with the outer sheath tube to fix the inner core tube or release the fixation of the inner core tube.

10. The esophageal mucosal continuous micro-perfusion catheter of claim 9, wherein the fastener comprises:

a manipulation part driven by an external force;

the thread part, screw thread part coaxial coupling in control the portion, the through-hole run through in screw thread part with control the portion, screw thread part with the screw interface threaded connection of the near end of sheath pipe, screw thread part with the screw interface state of screwing, the inner core pipe is fixed, screw thread part with the screw interface state of unscrewing, the inner core pipe is released fixedly.

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