CN112892891B - Centrifugal device for extracting anti-leukemia active molecules and intermediates - Google Patents
Centrifugal device for extracting anti-leukemia active molecules and intermediates Download PDFInfo
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- CN112892891B CN112892891B CN202110235203.9A CN202110235203A CN112892891B CN 112892891 B CN112892891 B CN 112892891B CN 202110235203 A CN202110235203 A CN 202110235203A CN 112892891 B CN112892891 B CN 112892891B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B11/00—Feeding, charging, or discharging bowls
- B04B11/04—Periodical feeding or discharging; Control arrangements therefor
Abstract
The invention discloses a centrifugal device for extracting leukemia-resistant active molecules and intermediates, which comprises a centrifugal equipment main body, a material conveying pipe, a material discharging pipe, a regulation and control plate, a regulation and control auxiliary round hole and a regulation and control locking mechanism, wherein the material conveying pipe is arranged on the centrifugal equipment main body; according to the centrifugal device for extracting the leukemia-resistant active molecules and the midbody, the conveying capacity of the centrifugal device can be controlled according to the actual material extraction requirement through the arranged regulation plate, the regulation auxiliary circular hole and the hand wheel, the stability of the regulation work of the centrifugal device can be improved through the arranged regulation locking mechanism, the material conveying pipe and the centrifugal device main body can be isolated when the centrifugal device carries out centrifugal extraction work while the control work of the conveying material capacity is realized, so that the materials are prevented from returning to the material conveying pipe, the extraction material is prevented from losing, and the centrifugal extraction work efficiency is ensured.
Description
Technical Field
The invention relates to the technical field of centrifugal equipment, in particular to a centrifugal device for extracting anti-leukemia active molecules and intermediates.
Background
Leukemia is a malignant disease of hematopoietic tissues, also known as leukemia; the precursor cells of a series of hematopoietic cells, mainly a leukocyte series, lose the differentiation and maturation ability, are in malignant clonal proliferation and accumulation in bone marrow and other hematopoietic tissues, invade liver, spleen and lymph nodes, and finally infiltrate and damage tissues and organs of the whole body, so that the normal hematopoietic function is inhibited; leukemia is different from solid tumors, is not a local neoplasm but a malignant blood disease which spreads throughout the body and can invade various systems, organs and tissues; the clinical manifestations are anemia, bleeding, infection and organ infiltration symptoms; leukemia is the first in the incidence of pediatric malignancies, and centrifugation techniques are commonly used in the prior art for the preparation and purification of anti-leukemia drugs.
Centrifugation, one of the most common methods for the separation of proteins, enzymes, nucleic acids and cellular subcomponents, is also the separation, purification or clarification method commonly used in biochemical laboratories; in particular, ultrafreeze centrifugation has become a common technical method in a laboratory for studying biomacromolecules, when centrifugal separation and purification are performed, materials to be separated and purified are conveyed into centrifugal equipment from a feeding conveying pipe, in the prior art, when the centrifugal equipment is subjected to filling work, the materials cannot be conveyed according to actual reaction conditions in a controlled amount, and when the reaction is performed, the conveying pipe on the equipment is communicated with the centrifugal reaction equipment, so that separated and purified materials can return to the conveying pipe, the loss of extracted materials is caused, and the working efficiency of centrifugal extraction is reduced.
Disclosure of Invention
The present invention is to solve the above problems of the prior art by providing a centrifugal apparatus for extracting leukemia inhibitory activity molecules and intermediates.
In order to achieve the purpose, the invention provides the following technical scheme: a centrifugal device for extracting leukemia-resistant active molecules and intermediates comprises a centrifugal equipment main body, a material conveying pipe, a material discharging pipe, a regulation and control plate, a regulation and control auxiliary circular hole and a regulation and control locking mechanism;
the centrifugal equipment main body is provided with a material conveying pipe and a material discharging pipe, a fixing ring is integrally formed on the material conveying pipe, and a fixing column is integrally formed on the side of the fixing ring;
the material conveying pipe is symmetrically and movably provided with a regulating plate, one end of the regulating plate is provided with a movable extrusion block, the regulating plate is symmetrically provided with a first return spring at the end connected with the movable extrusion block, and the other end of the movable extrusion block is movably arranged in a first arc-shaped extrusion chute;
the first arc-shaped extrusion chutes are equidistantly arranged in the movable sleeve ring, the movable sleeve ring is symmetrically sleeved on the material conveying pipe and movably arranged in the fixed ring, the outer side wall of the movable sleeve ring is integrally provided with first transmission gears, one of the first transmission gears is meshed and connected with a second transmission gear, the other first transmission gear is meshed and connected with a third transmission gear, the third transmission gears are symmetrically and movably arranged in the fixed column, and the third transmission gears and the second transmission gears are sleeved on the rotating shaft;
the rotating shaft is inserted into the fixed column, regulating auxiliary circular holes are equidistantly formed in a regulating plate connected with the third transmission gear, a hand wheel is arranged at one end of the rotating shaft, sleeve columns are sleeved on the rotating shaft and movably arranged in the fixed column, and positioning clamping grooves are equidistantly formed in the outer side walls of the sleeve columns;
the adjusting and controlling locking mechanism is arranged in the fixed column and is arranged at the side position of the sleeve column.
Preferably, regulation and control locking mechanical system includes activity circle piece, knob, second arc extrusion chute, circular locking groove, activity locking card post, locator card strip, the activity of activity circle piece sets up in the fixed column to the activity circle piece sets up the one end at the knob, and the knob is pegged graft and is set up in the fixed column, and one side of activity circle piece is provided with second arc extrusion chute to the opposite side is provided with circular locking groove, the activity of activity locking card post sets up the avris position at the activity circle piece, and the bilateral symmetry of activity locking card post is provided with first lug, is provided with second reset spring on the first lug, and the one end of activity locking card post is provided with the pull ring, the activity of locator card strip sets up the position at the activity circle piece to the activity of the one end of locator card strip sets up in second arc extrusion chute, and one side of locator card strip is provided with the second lug, is provided with third reset spring on the second lug.
Preferably, the first arc-shaped extrusion chute, the movable extrusion block and the regulation and control plate are arranged at corresponding positions and have the same number of groups, and four groups are arranged.
Preferably, the positioning clamping strip corresponds to the positioning clamping groove in position, and the width of the cross section of the end part of the positioning clamping strip is equal to the width of the notch of the positioning clamping groove.
Preferably, the movable locking clamping columns correspond to the round locking grooves in arrangement positions and are arranged in the same number, and the diameters of the movable locking clamping columns and the round locking grooves are equal.
Compared with the prior art, the invention has the beneficial effects that:
according to the centrifugal device for extracting the leukemia-resistant active molecules and the midbody, the conveying capacity of materials can be controlled according to the actual extraction requirement of the materials during centrifugal separation and extraction work through the arranged regulation and control plate, the regulation and control auxiliary circular hole and the hand wheel, the stability of the regulation and control work can be improved through the arranged regulation and control locking mechanism, the control work of the conveying capacity of the materials is realized, and meanwhile, when centrifugal extraction work is carried out on centrifugal equipment, the material conveying pipe and the centrifugal equipment main body can be isolated, so that the materials are prevented from returning to the material conveying pipe, the loss of the extracted materials is avoided, and the centrifugal extraction work efficiency is ensured.
Drawings
FIG. 1 is a schematic view of the structural connection of the present invention;
FIG. 2 is an enlarged partial view of the structural joint of FIG. 1 according to the present invention;
FIG. 3 is a schematic view of the front side of the connection between the fixing ring and the internal structure of the fixing post according to the present invention;
FIG. 4 is a schematic view of the rear side of the connection between the fixing ring and the internal structure of the fixing post according to the present invention;
FIG. 5 is an enlarged partial view of the structural joint of FIG. 4 according to the present invention;
FIG. 6 is a top view of the structural attachment of the modulating locking mechanism of the present invention;
FIG. 7 is an enlarged partial view of the structural joint of FIG. 6 according to the present invention;
FIG. 8 is a bottom view of the structural attachment of the modulating locking mechanism of the present invention;
fig. 9 is a partially enlarged view of the structural connection of fig. 8 according to the present invention.
In the figure: the centrifugal device comprises a centrifugal device main body 1, a material conveying pipe 2, a material discharging pipe 3, a fixing ring 4, a fixing column 5, a regulating plate 6, a movable extrusion block 7, a first arc-shaped extrusion chute 8, a movable lantern ring 9, a first transmission gear 10, a second transmission gear 11, a third transmission gear 12, a rotating shaft 13, a regulating auxiliary circular hole 14, a hand wheel 15, a sleeve column 16, a positioning clamping groove 17, a regulating locking mechanism 18, a movable circular block 1801, a knob 1802, a second arc-shaped extrusion chute 1803, a circular locking groove 1804, a movable locking clamping column 1805 and a positioning clamping strip 1806.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below. The embodiments of the present invention, and all other embodiments obtained by a person of ordinary skill in the art without any inventive work, belong to the scope of protection of the present invention.
Referring to fig. 1 to 9, the present invention provides a technical solution: the invention relates to a centrifugal device for extracting leukemia-resistant active molecules and intermediates, which comprises a centrifugal equipment main body 1, a material conveying pipe 2, a material discharging pipe 3, a regulation and control plate 6, a regulation and control auxiliary round hole 14 and a regulation and control locking mechanism 18;
a material conveying pipe 2 and a material discharging pipe 3 are arranged on the centrifugal equipment main body 1, a fixing ring 4 is integrally formed on the material conveying pipe 2, and a fixing column 5 is integrally formed on the side of the fixing ring 4;
the material conveying pipe 2 is symmetrically and movably provided with a regulating plate 6, one end of the regulating plate 6 is provided with a movable extrusion block 7, the regulating plate 6 is symmetrically provided with a first return spring at the connecting end with the movable extrusion block 7, and the other end of the movable extrusion block 7 is movably arranged in a first arc-shaped extrusion chute 8;
the first arc-shaped extrusion chutes 8 are equidistantly arranged in the movable lantern rings 9, the movable lantern rings 9 are symmetrically sleeved on the conveying pipeline 2 and are movably arranged in the fixed ring 4, the outer side wall of each movable lantern ring 9 is integrally provided with first transmission gears 10, one first transmission gear 10 is meshed with a second transmission gear 11, the other first transmission gear 10 is meshed with a third transmission gear 12, the third transmission gears 12 are symmetrically and movably arranged in the fixed columns 5, and the third transmission gears 12 and the second transmission gears 11 are sleeved on the rotating shafts 13;
the rotating shaft 13 is inserted into the fixed column 5, the regulating plate 6 connected with the third transmission gear 12 is provided with regulating auxiliary round holes 14 at equal intervals, one end of the rotating shaft 13 is provided with a hand wheel 15, the rotating shaft 13 is sleeved with a sleeve column 16, the sleeve column 16 is movably arranged in the fixed column 5, and the outer side wall of the sleeve column 16 is provided with positioning clamping grooves 17 at equal intervals;
the adjusting and locking mechanism 18 is arranged in the fixed column 5 and is arranged at the side position of the sleeve column 16.
Preferably, the first arc-shaped extrusion chutes 8 correspond to the movable extrusion blocks 7 and the regulating and controlling plate 6 in arrangement positions and are arranged in the same number of groups, and four groups are arranged.
Preferably, the adjusting and controlling locking mechanism 18 includes a movable circular block 1801, a rotary knob 1802, a second arc extrusion chute 1803, a circular locking slot 1804, a movable locking clip column 1805, a positioning clip strip 1806, the movable circular block 1801 is movably disposed in the fixed column 5, the movable circular block 1801 is disposed at one end of the rotary knob 1802, the rotary knob 1802 is inserted into the fixed column 5, one side of the movable circular block 1801 is provided with the second arc extrusion chute 1803, and the other side is provided with the circular locking slot 1804, the movable locking clip column 1805 is movably disposed at the side position of the movable circular block 1801, and two sides of the movable locking clip column 1805 are symmetrically provided with first convex blocks, the first convex blocks are provided with second return springs, one end of the movable locking clip column 1805 is provided with a pull ring, the positioning clip strip 1806 is movably disposed at the side position of the movable circular block 1801, and one end of the positioning clip strip 1806 is movably disposed in the second arc extrusion chute 1803, one side of the positioning clip strip 1806 is provided with a second convex block, and a third return spring is disposed on the second convex block.
Preferably, the positioning clip strip 1806 corresponds to the positioning clip slot 17, and the width of the cross section of the end of the positioning clip strip 1806 is equal to the width of the notch of the positioning clip slot 17.
Preferably, the movable locking posts 1805 and the circular locking slots 1804 are arranged at the same position and the same number of groups, and the diameters of the two are equal.
The working principle is as follows: for the centrifugal device for extracting the leukemia-resistant active molecules and the midbody, when the centrifugal device is in operation and material conveying regulation and control operation is required, the centrifugal device directly rotates the hand wheel 15, the hand wheel 15 drives the second transmission gear 11 and the third transmission gear 12 on the rotating shaft 13 to rotate, so as to drive the second transmission gear 11 to be in meshing transmission with the first transmission gear 10, the third transmission gear 12 is in meshing transmission with the first transmission gear 10, the first transmission gear 10 drives the first arc-shaped extrusion chute 8 on the movable lantern ring 9 to extrude the movable extrusion block 7, so that the movable extrusion block 7 pushes the regulation and control plate 6 to plug the pipe orifice of the material conveying pipe 2, so that the material flow in the material conveying pipe 2 is controlled, and in the process, the regulation and control auxiliary round hole 14 on the regulation and control plate 6 has a good auxiliary function on the material flow regulation and control operation, so that the material flow control is more stable, then the knob 1802 drives the movable circular block 1801 to rotate, the movable circular block 1801 on one hand drives the second arc extrusion chute 1803 to extrude the positioning clamp strip 1806, the positioning clamp strip 1806 is clamped in the positioning clamp groove 17 on the corresponding position of the sleeve column 16, meanwhile, the circular locking groove 1804 arranged on one side of the movable circular block 1801 reaches the position of the movable locking clamp column 1805, the movable locking clamp column 1805 is clamped in the circular locking groove 1804 under the action of the second reset spring, so that the positioning clamp strip 1806 is clamped and fixed in the positioning clamp groove 17, the hand wheel 15 is locked in position, the material flow control work can be completed, after the feeding work is completed, the material conveying pipe 2 needs to be plugged, the pull buckle on the movable locking clamp column 1805 is pulled at first, so that the movable locking clamp column 1805 is separated from the circular locking groove 1804, then, the knob 1802 is rotated reversely, so that the positioning clamp strips 1806 are separated from the positioning clamp grooves 17 under the action of a third return spring, then the hand wheel 15 is continuously rotated according to the same rotation direction, the conveying pipe 2 is plugged by the regulating and controlling plate 6, and then the hand wheel 15 is locked and fixed according to the same operation method, so that for the centrifugal device for extracting the anti-leukemia active molecules and the intermediates, which is designed by the invention, through the regulating and controlling plate 6, the regulating and controlling auxiliary round holes 14 and the hand wheel 15, when centrifugal separation and extraction are carried out, the conveying amount of the material can be controlled according to the actual material extraction requirement, and through the regulating and controlling locking mechanism 18, the stability of the regulating and controlling work can be improved, when the centrifugal device carries out centrifugal extraction work, the material conveying pipe can be isolated from the centrifugal device main body 1, so that the material is prevented from returning to the material conveying pipe, the loss of the extracted material is avoided, and the centrifugal extraction work efficiency is ensured.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (5)
1. A centrifugal device for extracting leukemia-resistant active molecules and intermediates, which is characterized in that: comprises a centrifugal equipment main body (1), a material conveying pipe (2), a material discharging pipe (3), a regulation and control plate (6), a regulation and control auxiliary round hole (14) and a regulation and control locking mechanism (18);
a material conveying pipe (2) and a material discharging pipe (3) are arranged on the centrifugal equipment main body (1), a fixing ring (4) is integrally formed on the material conveying pipe (2), and a fixing column (5) is integrally formed on the side of the fixing ring (4);
the material conveying pipe (2) is symmetrically and movably provided with an adjusting plate (6), one end of the adjusting plate (6) is provided with a movable extrusion block (7), the adjusting plate (6) is symmetrically provided with a first return spring at the end connected with the movable extrusion block (7), and the other end of the movable extrusion block (7) is movably arranged in a first arc-shaped extrusion chute (8);
the first arc-shaped extrusion chutes (8) are equidistantly arranged in movable lantern rings (9), the movable lantern rings (9) are symmetrically sleeved on the conveying pipe (2) and movably arranged in the fixed ring (4), first transmission gears (10) are integrally formed on the outer side wall of each movable lantern ring (9), one first transmission gear (10) is provided with a second transmission gear (11) in a meshed connection mode, the other first transmission gear (10) is provided with a third transmission gear (12) in a meshed connection mode, the third transmission gears (12) are symmetrically and movably arranged in the fixed column (5), and the third transmission gears (12) and the second transmission gears (11) are sleeved on the rotating shaft (13);
the rotating shaft (13) is inserted into the fixed column (5), the regulating plate (6) connected with the third transmission gear (12) is provided with regulating auxiliary round holes (14) at equal intervals, one end of the rotating shaft (13) is provided with a hand wheel (15), the rotating shaft (13) is sleeved with a sleeve column (16), the sleeve column (16) is movably arranged in the fixed column (5), and the outer side wall of the sleeve column (16) is provided with positioning clamping grooves (17) at equal intervals;
the adjusting and controlling locking mechanism (18) is arranged in the fixed column (5) and is arranged at the side position of the sleeve column (16).
2. The centrifugal apparatus for extracting an antileukemic active molecule and intermediate as claimed in claim 1, wherein: the adjustable locking mechanism (18) comprises a movable round block (1801), a knob (1802), a second arc extrusion chute (1803), a circular locking groove (1804), a movable locking clamp column (1805) and a positioning clamp strip (1806), wherein the movable round block (1801) is movably arranged in a fixed column (5), the movable round block (1801) is arranged at one end of the knob (1802), the knob (1802) is inserted in the fixed column (5), the second arc extrusion chute (1803) is arranged at one side of the movable round block (1801), the circular locking groove (1804) is arranged at the other side of the movable round block (1801), the movable locking clamp column (1805) is movably arranged at the side position of the movable round block (1801), first convex blocks are symmetrically arranged at two sides of the movable locking clamp column (1805), a second return spring is arranged on the first convex block, one end of the movable locking clamp column (1805) is provided with a pull ring, a pull ring is arranged at one side of the second arc extrusion chute (1803), and a return spring is arranged at one side of the movable clamp column (1806); the knob 1802 drives the movable round block 1801 to rotate, on one hand, the movable round block 1801 drives the second arc-shaped extrusion chute 1803 to extrude the positioning clamp strip 1806, and the positioning clamp strip 1806 is clamped in the positioning clamp groove 17 at the corresponding position of the sleeve column 16; so that the positioning clamping strip 1806 is clamped and fixed in the positioning clamping groove 17, and the position of the hand wheel 15 is locked; the knob 1802 is rotated in the reverse direction, and the keeper bar 1806 is separated from the keeper groove 17 by the third return spring.
3. The centrifugal apparatus for extracting leukemia inhibitory activity according to claim 1, wherein the centrifugal apparatus comprises: the first arc-shaped extrusion chutes (8) correspond to the movable extrusion blocks (7) and the regulating and controlling plate (6) in arrangement positions and are arranged in the same number, and four groups are arranged.
4. The centrifugal apparatus for extracting an antileukemic active molecule and intermediate as claimed in claim 2, wherein: the positioning clamping strip (1806) is corresponding to the positioning clamping groove (17) in position, and the width of the cross section of the end part of the positioning clamping strip (1806) is equal to the width of the notch of the positioning clamping groove (17).
5. The centrifugal apparatus for extracting an antileukemic active molecule and intermediate as claimed in claim 2, wherein: the movable locking clamping columns (1805) correspond to the round locking grooves (1804) in arrangement position and are arranged in the same number of groups, and the diameters of the movable locking clamping columns and the round locking grooves are equal.
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| CN202110235203.9A CN112892891B (en) | 2021-03-03 | 2021-03-03 | Centrifugal device for extracting anti-leukemia active molecules and intermediates |
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| CN202110235203.9A CN112892891B (en) | 2021-03-03 | 2021-03-03 | Centrifugal device for extracting anti-leukemia active molecules and intermediates |
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| CN112892891B true CN112892891B (en) | 2022-12-06 |
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| CN114100439A (en) * | 2021-11-11 | 2022-03-01 | 湖北三众环境建设工程有限公司 | Raw material mixing device for underground pipeline repairing material |
| CN115226450A (en) * | 2022-07-07 | 2022-10-25 | 盐城可理斯机械制造有限公司 | Fertilizer spreading amount regulating and controlling structure for fertilizer spreader |
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| CN211496090U (en) * | 2019-12-22 | 2020-09-15 | 湖南永诚精瓷科技有限公司 | Blowing device is used in production of special ceramic components and parts |
| CN212292893U (en) * | 2020-06-30 | 2021-01-05 | 湖南葆华环保科技有限公司 | Integrated air floatation equipment |
| CN112409431A (en) * | 2020-12-07 | 2021-02-26 | 武汉伯瑞恒医药科技有限公司 | Cytarabine structure analogue and preparation method and application thereof |
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