CN112867480A - Oral care compositions comprising N-alkyl-N-acylglucamines - Google Patents
Oral care compositions comprising N-alkyl-N-acylglucamines Download PDFInfo
- Publication number
- CN112867480A CN112867480A CN201880098740.XA CN201880098740A CN112867480A CN 112867480 A CN112867480 A CN 112867480A CN 201880098740 A CN201880098740 A CN 201880098740A CN 112867480 A CN112867480 A CN 112867480A
- Authority
- CN
- China
- Prior art keywords
- oral care
- care composition
- alkyl
- surfactants
- acylglucamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 212
- 239000004094 surface-active agent Substances 0.000 claims abstract description 45
- 150000001413 amino acids Chemical class 0.000 claims abstract description 31
- 238000000034 method Methods 0.000 claims abstract description 22
- 239000003082 abrasive agent Substances 0.000 claims abstract description 15
- 206010020751 Hypersensitivity Diseases 0.000 claims abstract description 8
- 208000026935 allergic disease Diseases 0.000 claims abstract description 8
- 230000009610 hypersensitivity Effects 0.000 claims abstract description 8
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 47
- 235000001014 amino acid Nutrition 0.000 claims description 30
- 239000004475 Arginine Substances 0.000 claims description 24
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 24
- 239000000606 toothpaste Substances 0.000 claims description 23
- 229940034610 toothpaste Drugs 0.000 claims description 23
- 239000004088 foaming agent Substances 0.000 claims description 22
- 239000003945 anionic surfactant Substances 0.000 claims description 21
- 229960003121 arginine Drugs 0.000 claims description 21
- 239000006260 foam Substances 0.000 claims description 21
- 239000011734 sodium Substances 0.000 claims description 20
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 17
- 150000003839 salts Chemical class 0.000 claims description 17
- 229910052708 sodium Inorganic materials 0.000 claims description 16
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 15
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 15
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 13
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 10
- 125000000217 alkyl group Chemical group 0.000 claims description 8
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 7
- 239000001506 calcium phosphate Substances 0.000 claims description 7
- 239000002736 nonionic surfactant Substances 0.000 claims description 7
- 229940088417 precipitated calcium carbonate Drugs 0.000 claims description 7
- RYJDNPSQBGFFSF-WCCKRBBISA-N (2s)-2-amino-5-(diaminomethylideneamino)pentanoic acid;carbonic acid Chemical compound OC(O)=O.OC(=O)[C@@H](N)CCCNC(N)=N RYJDNPSQBGFFSF-WCCKRBBISA-N 0.000 claims description 6
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 claims description 6
- 239000002280 amphoteric surfactant Substances 0.000 claims description 6
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 claims description 6
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 claims description 6
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 6
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 claims description 6
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 6
- 239000002888 zwitterionic surfactant Substances 0.000 claims description 6
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 5
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 5
- CAVXVRQDZKMZDB-UHFFFAOYSA-M sodium;2-[dodecanoyl(methyl)amino]ethanesulfonate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CCS([O-])(=O)=O CAVXVRQDZKMZDB-UHFFFAOYSA-M 0.000 claims description 5
- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 claims description 5
- 229960003237 betaine Drugs 0.000 claims description 4
- BLCJBICVQSYOIF-UHFFFAOYSA-N 2,2-diaminobutanoic acid Chemical compound CCC(N)(N)C(O)=O BLCJBICVQSYOIF-UHFFFAOYSA-N 0.000 claims description 3
- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 claims description 3
- 235000019739 Dicalciumphosphate Nutrition 0.000 claims description 3
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims description 3
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims description 3
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 3
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 3
- 239000004472 Lysine Substances 0.000 claims description 3
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims description 3
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims description 3
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims description 3
- 125000003342 alkenyl group Chemical group 0.000 claims description 3
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 3
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 claims description 3
- 229940043256 calcium pyrophosphate Drugs 0.000 claims description 3
- 239000003093 cationic surfactant Substances 0.000 claims description 3
- 229960002173 citrulline Drugs 0.000 claims description 3
- 235000013477 citrulline Nutrition 0.000 claims description 3
- 229960003624 creatine Drugs 0.000 claims description 3
- 239000006046 creatine Substances 0.000 claims description 3
- 235000019821 dicalcium diphosphate Nutrition 0.000 claims description 3
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims description 3
- 229940038472 dicalcium phosphate Drugs 0.000 claims description 3
- 229910000390 dicalcium phosphate Inorganic materials 0.000 claims description 3
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 3
- 229960002885 histidine Drugs 0.000 claims description 3
- 229960003646 lysine Drugs 0.000 claims description 3
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 3
- 229960003104 ornithine Drugs 0.000 claims description 3
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 3
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 3
- OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 claims description 3
- 229940099402 potassium metaphosphate Drugs 0.000 claims description 3
- 229920006395 saturated elastomer Polymers 0.000 claims description 3
- 239000000377 silicon dioxide Substances 0.000 claims description 3
- 235000019983 sodium metaphosphate Nutrition 0.000 claims description 3
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 3
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 3
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 3
- PECYZEOJVXMISF-UHFFFAOYSA-N 3-aminoalanine Chemical compound [NH3+]CC(N)C([O-])=O PECYZEOJVXMISF-UHFFFAOYSA-N 0.000 claims 1
- 239000000047 product Substances 0.000 description 33
- 229940024606 amino acid Drugs 0.000 description 26
- -1 calcium cations Chemical class 0.000 description 25
- 239000002245 particle Substances 0.000 description 23
- 239000003981 vehicle Substances 0.000 description 23
- 235000009697 arginine Nutrition 0.000 description 20
- 230000008719 thickening Effects 0.000 description 16
- 235000002639 sodium chloride Nutrition 0.000 description 15
- 229940083542 sodium Drugs 0.000 description 13
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 12
- 239000000796 flavoring agent Substances 0.000 description 12
- 239000002562 thickening agent Substances 0.000 description 12
- 235000013355 food flavoring agent Nutrition 0.000 description 11
- 239000004615 ingredient Substances 0.000 description 10
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 10
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 10
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 229910019142 PO4 Inorganic materials 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 229920000642 polymer Polymers 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 8
- 229940091249 fluoride supplement Drugs 0.000 description 7
- 235000021317 phosphate Nutrition 0.000 description 7
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 6
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 6
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 5
- 239000006172 buffering agent Substances 0.000 description 5
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 5
- 238000005187 foaming Methods 0.000 description 5
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- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 4
- 150000003751 zinc Chemical class 0.000 description 4
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- 150000001768 cations Chemical class 0.000 description 3
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- 229960003082 galactose Drugs 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229940005740 hexametaphosphate Drugs 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- 235000019534 high fructose corn syrup Nutrition 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
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- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
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- 239000000905 isomalt Substances 0.000 description 1
- 235000010439 isomalt Nutrition 0.000 description 1
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
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- 239000000845 maltitol Substances 0.000 description 1
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- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 description 1
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- 125000005341 metaphosphate group Chemical group 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
- 239000010445 mica Substances 0.000 description 1
- 229910052618 mica group Inorganic materials 0.000 description 1
- HWPKGOGLCKPRLZ-UHFFFAOYSA-M monosodium citrate Chemical compound [Na+].OC(=O)CC(O)(C([O-])=O)CC(O)=O HWPKGOGLCKPRLZ-UHFFFAOYSA-M 0.000 description 1
- 235000018342 monosodium citrate Nutrition 0.000 description 1
- 239000002524 monosodium citrate Substances 0.000 description 1
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- 229920001206 natural gum Polymers 0.000 description 1
- 235000019412 neotame Nutrition 0.000 description 1
- HLIAVLHNDJUHFG-HOTGVXAUSA-N neotame Chemical compound CC(C)(C)CCN[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 HLIAVLHNDJUHFG-HOTGVXAUSA-N 0.000 description 1
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- 230000007935 neutral effect Effects 0.000 description 1
- 235000013615 non-nutritive sweetener Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
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- UYDLBVPAAFVANX-UHFFFAOYSA-N octylphenoxy polyethoxyethanol Chemical compound CC(C)(C)CC(C)(C)C1=CC=C(OCCOCCOCCOCCO)C=C1 UYDLBVPAAFVANX-UHFFFAOYSA-N 0.000 description 1
- ZVVSSOQAYNYNPP-UHFFFAOYSA-N olaflur Chemical compound F.F.CCCCCCCCCCCCCCCCCCN(CCO)CCCN(CCO)CCO ZVVSSOQAYNYNPP-UHFFFAOYSA-N 0.000 description 1
- 229960001245 olaflur Drugs 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- MPQXHAGKBWFSNV-UHFFFAOYSA-N oxidophosphanium Chemical group [PH3]=O MPQXHAGKBWFSNV-UHFFFAOYSA-N 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- CCTIOCVIZPCTGO-BYPYZUCNSA-N phosphoarginine Chemical compound OC(=O)[C@@H](N)CCCNC(=N)NP(O)(O)=O CCTIOCVIZPCTGO-BYPYZUCNSA-N 0.000 description 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 1
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- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 229940068965 polysorbates Drugs 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 239000000565 sealant Substances 0.000 description 1
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 229960000414 sodium fluoride Drugs 0.000 description 1
- 229940075560 sodium lauryl sulfoacetate Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 description 1
- DOJOZCIMYABYPO-UHFFFAOYSA-M sodium;3,4-dihydroxy-4-oxobutanoate Chemical compound [Na+].OC(=O)C(O)CC([O-])=O DOJOZCIMYABYPO-UHFFFAOYSA-M 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 description 1
- XOLBLPGZBRYERU-UHFFFAOYSA-N tin dioxide Chemical compound O=[Sn]=O XOLBLPGZBRYERU-UHFFFAOYSA-N 0.000 description 1
- 229910001887 tin oxide Inorganic materials 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000036347 tooth sensitivity Effects 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
- VSJRDSLPNMGNFG-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate;trihydrate Chemical compound O.O.O.[Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O VSJRDSLPNMGNFG-UHFFFAOYSA-H 0.000 description 1
- BIKXLKXABVUSMH-UHFFFAOYSA-N trizinc;diborate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]B([O-])[O-].[O-]B([O-])[O-] BIKXLKXABVUSMH-UHFFFAOYSA-N 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- GAAKLDANOSASAM-UHFFFAOYSA-N undec-10-enoic acid;zinc Chemical compound [Zn].OC(=O)CCCCCCCCC=C GAAKLDANOSASAM-UHFFFAOYSA-N 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000004246 zinc acetate Substances 0.000 description 1
- 235000013904 zinc acetate Nutrition 0.000 description 1
- 239000011667 zinc carbonate Substances 0.000 description 1
- 235000004416 zinc carbonate Nutrition 0.000 description 1
- 229910000010 zinc carbonate Inorganic materials 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
- 235000006076 zinc citrate Nutrition 0.000 description 1
- 229940068475 zinc citrate Drugs 0.000 description 1
- 229940085658 zinc citrate trihydrate Drugs 0.000 description 1
- SRWMQSFFRFWREA-UHFFFAOYSA-M zinc formate Chemical compound [Zn+2].[O-]C=O SRWMQSFFRFWREA-UHFFFAOYSA-M 0.000 description 1
- 239000011670 zinc gluconate Substances 0.000 description 1
- 235000011478 zinc gluconate Nutrition 0.000 description 1
- 229960000306 zinc gluconate Drugs 0.000 description 1
- 229940032991 zinc picolinate Drugs 0.000 description 1
- 235000019352 zinc silicate Nutrition 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- 229940118257 zinc undecylenate Drugs 0.000 description 1
- VRGNUPCISFMPEM-ZVGUSBNCSA-L zinc;(2r,3r)-2,3-dihydroxybutanedioate Chemical compound [Zn+2].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O VRGNUPCISFMPEM-ZVGUSBNCSA-L 0.000 description 1
- JNPQFTCBVDSMDO-UHFFFAOYSA-L zinc;2,3-dihydroxypropanoate Chemical compound [Zn+2].OCC(O)C([O-])=O.OCC(O)C([O-])=O JNPQFTCBVDSMDO-UHFFFAOYSA-L 0.000 description 1
- MCOGTQGPHPAUJN-UHFFFAOYSA-L zinc;2-hydroxyacetate Chemical compound [Zn+2].OCC([O-])=O.OCC([O-])=O MCOGTQGPHPAUJN-UHFFFAOYSA-L 0.000 description 1
- WDHVIZKSFZNHJB-UHFFFAOYSA-L zinc;butanoate Chemical compound [Zn+2].CCCC([O-])=O.CCCC([O-])=O WDHVIZKSFZNHJB-UHFFFAOYSA-L 0.000 description 1
- XDWXRAYGALQIFG-UHFFFAOYSA-L zinc;propanoate Chemical compound [Zn+2].CCC([O-])=O.CCC([O-])=O XDWXRAYGALQIFG-UHFFFAOYSA-L 0.000 description 1
- NHVUUBRKFZWXRN-UHFFFAOYSA-L zinc;pyridine-2-carboxylate Chemical compound C=1C=CC=NC=1C(=O)O[Zn]OC(=O)C1=CC=CC=N1 NHVUUBRKFZWXRN-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Oral care compositions and methods for use thereof are disclosed. The oral care composition may include an orally acceptable vehicle and one or more surfactants. The one or more surfactants may include N-alkyl-N-acylglucamines. The oral care composition may further comprise an amino acid and one or more abrasives. Methods for treating or reducing dentinal hypersensitivity can include contacting the oral care composition with a tooth surface.
Description
Background
Dentin or dentinal hypersensitivity is a common clinical condition associated with exposed dentinal surfaces of teeth. Dentin contains a large number of pores or dentinal tubules that extend from the outer surface of the tooth to the nerves within the tooth. Thus, exposure of dentin often results in increased sensitivity of the tooth to external stimuli (e.g., temperature, pressure, etc.). In view of the above, conventional oral care products or compositions thereof often may attempt to numb nerves or incorporate fillers or sealants to improve the sensitivity of the teeth. For example, conventional oral care compositions (e.g., Colgate Sensitive)) Arginine and calcium carbonate are often included as blocking agents that occlude dentin and reduce sensitivity.
While conventional oral care compositions have proven effective in reducing sensitivity, the active ingredient (e.g., arginine, calcium carbonate, etc.) can often react with one or more foaming agents in the oral care composition, thereby reducing the ability of the oral care composition to generate foam. For example, conventional oral care compositions primarily utilize anionic surfactants, such as sodium lauryl sulfate, as the primary foaming agent. However, anionic surfactants react with the calcium cations provided by the cationically charged arginine and calcium carbonate to produce insoluble salts, thereby reducing the availability of foaming agents and their foaming capacity.
There is, then, a need for improved desensitizing oral care compositions and methods for the same.
Disclosure of Invention
This summary is intended merely to introduce a simplified summary of some aspects of one or more embodiments of the disclosure. Further areas of applicability of the present disclosure will become apparent from the detailed description provided hereinafter. This summary is not an extensive overview, is not intended to identify key or critical elements of the teachings or to delineate the scope of the disclosure. Rather, its sole purpose is to present one or more concepts in a simplified form as a prelude to the more detailed description that is presented later.
The foregoing and/or other aspects and utilities embodied in the present disclosure may be achieved by providing an oral care composition comprising an orally acceptable vehicle and one or more surfactants. The one or more surfactants may include N-alkyl-N-acylglucamines.
In at least one embodiment, the oral care composition may further comprise an amino acid. In at least one embodiment, the amino acids may include one or more of the following: arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutyric acid, diaminopropionic acid, salts thereof, or combinations thereof. In at least one embodiment, the amino acid may comprise arginine, optionally, the arginine is provided by arginine bicarbonate, further optionally, the arginine is provided by arginine bicarbonate solution.
In at least one embodiment, the oral care composition can further comprise an abrasive. In at least one embodiment, the abrasive may include one or more of the following: sodium metaphosphate, potassium metaphosphate, calcium pyrophosphate, magnesium orthophosphate, trimagnesium orthophosphate, tricalcium phosphate, dicalcium phosphate dihydrate, anhydrous dicalcium phosphate, calcium carbonate, magnesium carbonate, hydrated alumina, silica, zirconium silicate, aluminum silicate, calcined aluminum silicate, polymethyl methacrylate, or a combination thereof. In at least one embodiment, the abrasive may comprise calcium carbonate, optionally, the calcium carbonate may comprise natural calcium carbonate and/or precipitated calcium carbonate.
In at least one embodiment, the N-alkyl-N-acylglucamines can be represented by formula (I), as disclosed herein, wherein R isaMay be straight or branched, saturated or unsaturated C6-C22Alkyl, or alkyl or mono-or polyunsaturated alkenyl, and wherein RbIs C1-C4An alkyl group. In at least one embodiment, the N-alkyl-N-acylglucamines may include N-methyl-N-acylglucamines. In at least one embodiment, the N-alkyl-N-acylglucamines can include N-methyl-N-C8-C10-acylglucamine and/or N-methyl-N-C12-C14-an acylglucamine.
In at least one embodiment, the one or more surfactants may further comprise one or more anionic surfactants, one or more nonionic surfactants, one or more cationic surfactants, one or more amphoteric surfactants, one or more zwitterionic surfactants, or a combination thereof.
In at least one embodiment, the one or more surfactants may further comprise an anionic surfactant, optionally the anionic surfactant may comprise sodium N-methyl-N-alkyltaurate, optionally the sodium N-methyl-N-alkyltaurate may comprise sodium cocoyl methyltaurate and sodium lauroyl methyltaurate.
In at least one embodiment, the one or more surfactants may further comprise a betaine and a sultaine, optionally, the betaine comprises cocamidopropyl betaine.
In at least one embodiment, the oral care composition may be free or substantially free of sodium lauryl sulfate.
In at least one embodiment, the oral care composition is a toothpaste.
The foregoing and/or other aspects and utilities embodied in the present disclosure may be achieved by providing a method for treating dentinal hypersensitivity in a human, which may include contacting any one or more of the oral care compositions disclosed herein with teeth or a surface of the human.
The foregoing and/or other aspects and utilities embodied in the present disclosure may be achieved by providing any one or more of the oral care compositions disclosed herein for treating dentinal hypersensitivity in a human.
The foregoing and/or other aspects and utilities embodied in the present disclosure may be achieved by providing a method of preparing an oral care composition with increased foam generation. The method may comprise combining an orally acceptable vehicle with at least one N-alkyl-N-acylglucamine and optionally at least one additional surfactant or foaming agent. The method may further comprise adding one or more amino acids and one or more abrasives to the orally acceptable vehicle and the at least one N-alkyl-N-acylglucamine.
Further areas of applicability of the present disclosure will become apparent from the detailed description provided hereinafter. It should be understood that the detailed description and specific examples, while indicating some exemplary aspects of the disclosure, are intended for purposes of illustration only and are not intended to limit the scope of the disclosure.
Detailed Description
The following description of various exemplary aspects is merely exemplary in nature and is in no way intended to limit the disclosure, its application, or uses.
As used throughout this disclosure, ranges are used as a shorthand way of describing each and every value that is within the range. It is to be understood and appreciated that the description in range format is merely for convenience and brevity and should not be construed as a rigid limitation on the scope of any embodiments or implementations disclosed herein. Accordingly, the disclosed ranges should be construed as specifically disclosing all possible sub-ranges and individual numerical values within the ranges. Thus, any value within the range can be selected as the terminus of the range. For example, a description of a range such as 1 to 5 should be considered to have specifically disclosed sub-ranges such as 1.5 to 3, 1 to 4.5, 2 to 5, 3.1 to 5, etc., as well as individual numbers within that range, e.g., 1, 2, 3, 3.2, 4, 5, etc. This applies regardless of the breadth of the range.
All references cited herein are incorporated by reference in their entirety. In the event of a conflict in a definition in the present disclosure and a definition in a cited reference, the present disclosure controls.
Unless otherwise indicated, all percentages and amounts expressed herein and elsewhere in this specification are to be understood as referring to weight percentages.
In addition, all numerical values are "about" or "approximately" the stated value, and experimental error and variation as contemplated by one of ordinary skill in the art are contemplated. It is to be understood that all values and ranges disclosed herein are approximate values and ranges, regardless of whether "about" is used in connection therewith. It is also to be understood that, as used herein, the term "about" in conjunction with a number refers to a value that may be ± 0.01% (inclusive), ± 0.1% (inclusive), ± 0.5% (inclusive), ± 1% (inclusive), ± 2% (inclusive), ± 3% (inclusive), ± 5% (inclusive), ± 10% (inclusive), or ± 15% (inclusive) of the number. It should be further understood that when numerical ranges are disclosed herein, any number falling within the range is also specifically disclosed.
The present inventors have surprisingly and unexpectedly discovered that N-alkyl-N-acylglucamines, such as N-methyl-N-C, are utilized8-C10-acylglucamine and/or N-methyl-N-C12-C14-an acylglucamine as a foaming agent, the oral care composition exhibiting relatively greater foam generation compared to conventional oral care compositions comprising conventional surfactants such as sodium lauryl sulfate. It will be appreciated that oral care compositions comprising N-alkyl-N-acylglucamines exhibit relatively greater foam generation at relatively lower concentrations, and that the foam generated is relatively denser, richer, and/or more creamy than foams generated from conventional oral care compositions comprising conventional surfactants. It has also been surprisingly and unexpectedly found that supplementation of the N-alkyl-N-acylglucamines with additional surfactants or foaming agents (whether active or inactive) further enhances foam generation in oral care compositions as compared to conventional oral care compositions.
Composition comprising a metal oxide and a metal oxide
The compositions disclosed herein may be or include an oral care product or oral care composition thereof. For example, the compositions disclosed herein can be oral care products comprising an oral care composition or an oral care composition thereof. In at least one embodiment, the compositions disclosed herein can be or include an oral care composition that includes an orally acceptable vehicle or carrierAnd at least one N-alkyl-N-acylglucamine capable of or configured to provide relatively greater foam generation compared to conventional oral care compositions. For example, the compositions disclosed herein can be or include an oral care composition, such as a toothpaste composition for sensitive teeth, comprising an orally acceptable vehicle or carrier and at least one N-alkyl-N-acylglucamine, such as N-methyl-N-C, capable of or configured to provide relatively greater foam generation as compared to conventional oral care compositions8-C10-acylglucamine and/or N-methyl-N-C12-C14-acylglucamines, said conventional oral care compositions making use of conventional cationically charged surfactants, such as Sodium Lauryl Sulfate (SLS). In at least one embodiment, the oral care composition can include an orally acceptable vehicle or carrier, one or more N-alkyl-N-acylglucamines, one or more amino acids, and one or more abrasives. In another embodiment, the oral care composition may include an orally acceptable vehicle or carrier, one or more N-alkyl-N-acylglucamines and at least one additional surfactant or foaming agent, one or more amino acids (e.g., arginine), and one or more abrasives (e.g., calcium carbonate).
Illustrative oral care products or compositions of the present disclosure can be or include, but are not limited to, a toothpaste (dentifrice), a prophylactic paste, a dentifrice, or a tooth gel (e.g., whitening gel). In exemplary embodiments, the oral care compositions disclosed herein can be a dentifrice or toothpaste. For example, the oral care compositions disclosed herein can be a toothpaste for treating tooth sensitivity or dentinal hypersensitivity.
The oral care product or oral care composition thereof may be a single phase oral care product or a single phase oral care composition. For example, all components of the oral care product or oral care composition thereof can be held together in a single phase and/or single container. For example, all components of the oral care product or oral care composition thereof can be maintained in a single phase, such as a single homogeneous phase. In another embodiment, the oral care product or oral care composition thereof may be a multi-phase oral care product or multi-phase oral care composition.
The oral care product or oral care composition thereof prior to use may have a "low water content". As used herein, "low water content" may refer to compositions containing water in an amount greater than about 5% by weight and less than about 15%, less than about 13%, less than about 10%, or less than about 7% by weight, based on the total weight of the oral care composition. In another embodiment, the oral care product or oral care composition thereof may be an anhydrous formulation or anhydrous composition. For example, the oral care composition prior to use can be anhydrous, non-aqueous, or substantially non-aqueous. As used herein, "free of water" or "substantially free of water" based on the total weight of the oral care composition can refer to compositions containing water in an amount of less than 5.0 wt.%, less than 3.0 wt.%, less than 1.0 wt.%, less than 0.1 wt.%, less than 0.05 wt.%, less than 0.01 wt.%, less than 0.005 wt.%, or less than 0.0001 wt.%.
Amino acids
The oral care composition may include one or more amino acids. The one or more amino acids in the oral care composition can be in free or salt form. Illustrative amino acids that may be used in the oral care composition may include, but are not limited to, arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutyric acid, diaminopropionic acid, salts thereof, and/or combinations thereof. The amino acids in the oral care composition can generally be present in the L-form or L-configuration. The amino acids may be provided in the form of salts of di-or tripeptides including amino acids. In at least one embodiment, at least a portion of the amino acids present in the oral care composition are in the form of a salt. In a preferred embodiment, the oral care composition comprises at least an arginine (e.g., L-arginine) or arginine source. Arginine may be provided as free arginine or a salt thereof. For example, arginine may be provided as arginine phosphate, arginine hydrochloride, arginine sulfate, arginine bicarbonate, and the like, as well as mixtures or combinations thereof. The one or more amino acids may be provided in solution or solid form. For example, one or more amino acids may be provided in aqueous solution. In preferred embodiments, the one or more amino acids comprise or are provided by an arginine bicarbonate solution.
The amount or concentration of the one or more amino acids present in the oral care composition can vary widely. In at least one embodiment, the amount or concentration of the one or more amino acids can be from greater than 0 weight% to about 20 weight%, based on the total weight of the oral care composition. For example, the one or more amino acids may be present in the oral care composition in an amount of greater than 0 weight%, about 2 weight%, about 4 weight%, about 6 weight%, about 8 weight%, or about 10 weight% to about 12 weight%, about 14 weight%, about 16 weight%, about 18 weight%, or about 20 weight%, based on the total weight of the oral care composition. In another example, the one or more amino acids may be present in the oral care composition in an amount of from greater than 0 wt% to about 20 wt%, from about 4 wt% to about 12 wt%, from about 6 wt% to about 10 wt%, or about 8 wt%, based on the total weight of the oral care composition. In preferred embodiments, the oral care composition comprises from about 6 wt% to about 10 wt% or about 8 wt%, based on the total weight of the oral care composition, and the amino acid may be provided from a solution. For example, the amino acid may be provided by an approximately 40% solution with one or more amino acids such as arginine.
Abrasives or abrasive systems
The oral care composition may include one or more abrasives or an abrasive system including one or more abrasives. As used herein, the term "abrasive" may also refer to materials commonly referred to as "polishing agents". Any orally acceptable abrasive can be used, but preferably, the type, fineness (particle size), and amount of abrasive can be selected so that tooth enamel is not excessively abraded in normal use of the oral care composition.
The one or more abrasives can have a particle size of less than or equal to about 10 μm, less than or equal to about 8 μm, less than or equal to about 5 μm, or less than or equal to about 3 μm or D50. The one or more abrasives can have a particle size of greater than or equal to about 0.01 μm, greater than or equal to about 0.05 μm, greater than or equal to about 0.1 μm, greater than or equal to about 0.5 μm, or greater than or equal to about 1 μm or D50. Illustrative abrasives can include, but are not limited to, metaphosphate compounds, phosphates (e.g., insoluble phosphates), such as sodium metaphosphate, potassium metaphosphate, calcium pyrophosphate, magnesium orthophosphate, trimagnesium orthophosphate, tricalcium phosphate, dicalcium phosphate dihydrate, anhydrous dicalcium phosphate, calcium carbonate (e.g., precipitated calcium carbonate and/or natural calcium carbonate), magnesium carbonate, hydrated alumina, silica, zirconium silicate, aluminum silicate (including calcined aluminum silicate), polymethyl methacrylate, and the like, and mixtures or combinations thereof.
In a preferred embodiment, the oral care composition comprises at least calcium carbonate as an abrasive. In at least one embodiment, precipitated calcium carbonate may be preferred over natural calcium carbonate. While not intending to be bound by theory, it is believed that natural calcium carbonate has a relatively greater degree of crystallinity or a relatively more crystalline structure than precipitated calcium carbonate, thereby making the calcium carbonate very hard. In contrast, precipitated calcium carbonate is relatively more amorphous and more brittle or crumbly. Thus, precipitated calcium carbonate has relatively low abrasion resistance compared to natural calcium carbonate, while maintaining sufficient cleaning power.
The one or more abrasives in the abrasive system can have a Pellicle Cleaning Ratio (PCR) of greater than or equal to 80, greater than or equal to 82, greater than or equal to 84, greater than or equal to 86, greater than or equal to 88, greater than or equal to 90, greater than or equal to 92, greater than or equal to 94, greater than or equal to 96, greater than or equal to 98, greater than or equal to 100, greater than or equal to 102, greater than or equal to 104, greater than or equal to 106, greater than or equal to 108, greater than or equal to 110, greater than or equal to 112, or greater.
The amount or concentration of the one or more abrasives present in the oral care composition can vary widely. In at least one embodiment, the amount or concentration of abrasive can be from greater than 0 weight% to about 60 weight%, based on the total weight of the oral care composition. For example, the amount of abrasive present in the oral care composition can be greater than 0, about 2, about 4, about 6, about 8, about 10, about 12, about 14, about 16, about 18, or about 19 to about 21, about 22, about 24, about 26, about 28, about 30, about 32, about 34, about 36, about 38, or about 40 weight percent. In another example, the abrasive can be present in the oral care composition in an amount of greater than 0 wt% to about 40 wt%, about 2 wt% to about 38 wt%, about 4 wt% to about 36 wt%, about 6 wt% to about 34 wt%, about 8 wt% to about 32 wt%, about 10 wt% to about 30 wt%, about 12 wt% to about 28 wt%, about 14 wt% to about 26 wt%, about 16 wt% to about 24 wt%, about 18 wt% to about 22 wt%, or about 19 wt% to about 21 wt%. In preferred embodiments, the abrasive may be present in the oral care composition in an amount of from about 25 wt.% to about 45 wt.%, preferably from about 30 wt.% to about 40 wt.%, or more preferably about 35 wt.%, based on the total weight of the oral care composition.
Surfactants or foaming systems
The oral care composition may include one or more surfactants or foaming agents capable of or configured to provide relatively greater foam generation than conventional oral care compositions.
In at least one embodiment, the one or more surfactants or foaming agents may include at least one N-alkyl-N-acylglucamine. In another embodiment, the one or more surfactants or foaming agents may include at least one N-alkyl-N-acylglucamine and an additional surfactant. For example, the one or more surfactants or foaming agents may include at least one N-alkyl-N-acylglucamine as the active surfactant or foaming agent, and at least one additional surfactant or foaming agent. The additional surfactant or foaming agent may be a reactive surfactant or a non-reactive surfactant.
The N-alkyl-N-acylglucamines can be represented by formula (I),
wherein R isaIs straight-chain or branched, saturated or unsaturated C6-C22Alkyl, or alkyl or mono-or polyunsaturated alkenyl, and RbIs C1-C4An alkyl group. In a preferred embodiment, the N-alkyl-N-acylglucamine may be or include N-methyl-N-acylglucamine. For example, the one or more N-alkyl-N-acylglucamines can be or include N-methyl-N-C8-C10-acylglucamine and/or N-methyl-N-C12-C14-an acylglucamine. In at least one embodiment, the N-alkyl-N-acylglucamines can be or includeWET (CAS number 1591782-62-5) and/orDEG (CAS number 287735-50-6), each commercially available from Clariant Corp., Charlotte, NC.
The additional surfactant of the foaming agent may be or include, but is not limited to, one or more anionic surfactants, one or more nonionic surfactants, one or more cationic surfactants, one or more amphoteric surfactants, one or more zwitterionic surfactants, or a combination thereof.
Anionic surfactants may be or include, but are not limited to, water soluble salts of C8-20 alkyl sulfates, sulfonated monoglycerides of C8-20 fatty acids, sarcosinates, taurates, and the like. Illustrative anionic surfactants may also be or include, but are not limited to, sodium lauryl sulfate, sodium cocoyl monoglyceride sulfonate, sodium lauryl sarcosinate, sodium lauryl isoethanedisulfonate, sodium laureth carboxylate, sodium lauroyl methyl taurate, and sodium dodecyl benzene sulfonate. Additional illustrative anionic surfactants can be or include, but are not limited to, water soluble salts of higher fatty acid monoglyceride monosulfates, such as the sodium salt of the monosulfated monoglyceride of hydrogenated coconut oil fatty acids, such as sodium N-methyl-N-alkyltaurateSodium N-methyl-N-cocoyl taurate or sodium methyl cocoyl taurate, sodium cocoyl methyl taurate, sodium lauroyl methyl taurate, sodium coco-glyceride sulfate; higher alkyl sulfates, such as sodium lauryl sulfate; higher alkyl-ether sulfates, e.g. of the formula CH3(CH2)mCH2(OCH2CH2)nOSO3Higher alkyl-ether sulfates of X, wherein m is 6 to 16, e.g. 10, n is 1 to 6, e.g. 2, 3 or 4, and X is Na, e.g. sodium lauryl ether-2 sulfate (CH)3(CH2)10CH2(OCH2CH2)2OSO3Na); higher alkyl aryl sulfonates such as sodium dodecylbenzene sulfonate (sodium dodecylbenzene sulfonate); higher alkyl sulfoacetates, such as sodium lauryl sulfoacetate (sodium dodecyl sulfoacetate), higher fatty acid esters of 1, 2-dihydroxypropanesulfonic acid, sulfolaurate (sulfolaurate) (potassium N-2-ethyllaurate sulfoacetamide), and sodium lauryl sarcosinate. As used herein, "higher alkyl" may refer to C6-C30An alkyl group. In at least one embodiment, the anionic surfactant may include one or more sodium N-methyl-N-alkyltaurates, such as sodium cocoyl methyltaurate, sodium lauroyl methyltaurate, and the like, and combinations thereof. When present, the anionic surfactant is present in an amount that is effective (e.g., greater than or equal to about 0.001% by weight of the formulation), but not at a concentration that will stimulate oral tissue (e.g., greater than or equal to about 1%), and the optimal concentration depends on the particular formulation and the particular surfactant.
In at least one preferred embodiment, the oral care composition comprises one or more N-methyl-N-acylglucamines and at least one anionic surfactant. For example, the oral care composition includes one or more of N-methyl-N-acylglucamine and sodium N-methyl-N-cocoyl taurate or sodium methyl cocoyl taurate.
In at least one embodiment, the anionic surfactant utilized in the oral care composition does not include sodium lauryl sulfate. For example, as further described herein, the oral care composition can be free or substantially free of sodium lauryl sulfate. As used herein, "free of or" substantially free of a material may refer to a composition, component, or phase in which the material is present in an amount less than 10.0 wt.%, less than 5.0 wt.%, less than 3.0 wt.%, less than 1.0 wt.%, less than 0.1 wt.%, less than 0.05 wt.%, less than 0.01 wt.%, less than 0.005 wt.%, or less than 0.0001 wt.%, based on the total weight of the composition, component, or phase.
Amphoteric and zwitterionic surfactants can be or include, but are not limited to, C with an anionic group, such as carboxylate, sulfate, sulfonate, phosphate, or phosphonate8-20Derivatives of aliphatic secondary and tertiary amines. Illustrative amphoteric and zwitterionic surfactants can include, but are not limited to, sulfobetaines and betaines, such as cocamidopropyl betaine (CAPB); derivatives of aliphatic secondary and tertiary amines in which the aliphatic radicals can be straight or branched chain and in which one of the aliphatic substituents contains from about 8 to about 18 carbon atoms and one contains an anionic water-solubilizing group (e.g., carboxylate, sulfonate, sulfate, phosphate, phosphonate, or the like); and combinations thereof. In at least one preferred embodiment, the oral care composition comprises one or more N-methyl-N-acylglucamines and at least one amphoteric and/or zwitterionic surfactant. For example, the oral care composition includes one or more N-methyl-N-acylglucamines and one or more betaines, such as cocamidopropyl betaine.
Illustrative nonionic surfactants can be or include, but are not limited to, octoxynol (e.g., polyethylene glycol tetramethylbutyl phenyl ether, octylphenoxy polyethoxyethanol, or polyoxyethylene octylphenyl ether), such as octoxynol 1, 3, 5, 8, 9, 10, 12, 13, 16, 30, 40, 70, where the number indicates the number of repeating oxyethylene units or other octoxynol that includes a different number of oxyethylene repeating units in the side chain, sorbitan esters (e.g., typically under the trade name thereof)80 and60 known sorbitan monooleate, sorbitan monostearate and the like), polysorbates (for example, commonly known under their trade names80、60、20 Polysorbate 80 (polyoxyethylene sorbitan monooleate), Polysorbate 60 (polyoxyethylene sorbitan monostearate), Polysorbate 20 (polyoxyethylene sorbitan monolaurate), Poloxamer (a synthetic block polymer of ethylene oxide and propylene oxide, as commonly known under the trade name Polyoxyethylene sorbitan monooleate), Poloxamer (a synthetic block polymer of ethylene oxide and propylene oxide), are knownThose known as such; for exampleF127 orF108) Or poloxamines (synthetic block polymers of ethylene oxide and propylene oxide linked to ethylenediamine, as commonly known under the trade name poloxaminesThose known as such; for example1508 or908, etc.), other nonionic surfactants such as(having the formula CH3-(CH2)10-16-(O-C2H4)1-25Polyoxyethylene alkyl ethers of-OH),(stearic acid esterified with a polyoxyethylene having 40-100 repeating oxyethylene units), and long chain fatty alcohols having a carbon chain of about 12 or more carbon atoms (e.g., about 12 to about 24 carbon atoms) (e.g., oleyl alcohol, stearyl alcohol, myristyl alcohol, docosahexanol, etc.). Additional nonionic surfactants can be or include, but are not limited to, polyethylene oxide condensates of alkyl phenols, products derived from the condensation of ethylene oxide with the reaction products of propylene oxide and ethylenediamine, ethylene oxide condensates of aliphatic alcohols, long chain tertiary amine oxides, long chain tertiary phosphine oxides, long chain dialkyl sulfoxides, and the like, or combinations thereof. In at least one embodiment, a nonionic surfactant can be generally defined as a compound produced by the condensation of alkylene oxide groups (hydrophilic in nature) with an organic hydrophobic compound that may be aliphatic or alkyl aromatic in nature.
In at least one embodiment, the oral care composition may be free or substantially free of one or more surfactants capable of or configured to react with one or more of the cationic or cationically charged ingredients/components of the oral care composition to form an insoluble salt. For example, the oral care composition may be free or substantially free of one or more surfactants capable of or configured to react with one or more cationic or cationically charged amino acids (such as arginine). In another embodiment, the oral care composition may be free or substantially free of one or more surfactants capable of or configured to react with one or more cations provided or released by one or more ingredients/components of the oral care composition. For example, the oral care composition may be free or substantially free of one or more surfactants capable of or configured to react with one or more cations provided by one or more salts (e.g., inorganic salts) contained therein. For example, the oral care composition may be free or substantially free of one or more surfactants capable of or configured to react with one or more calcium ions provided by one or more abrasives (e.g., calcium carbonate, etc.) of the oral care composition.
As discussed above, in at least one exemplary embodiment, the oral care composition may be free or substantially free of sodium lauryl sulfate or similar anionic surfactants. It will be appreciated that sodium lauryl sulfate and/or anionic surfactants similar thereto may react at least partially with cationically charged species, such as partially cationically charged arginine and/or cations, e.g., calcium ions from calcium carbonate, to form inorganic salts. It is further appreciated that the reaction of sodium lauryl sulfate and/or anionic surfactants similar thereto may reduce the availability and/or foaming capacity of sodium lauryl sulfate and/or anionic surfactants similar thereto; and, therefore, reduce foaming of the oral care composition. Thus, in at least one exemplary embodiment, the oral care composition may be free or substantially free of sodium lauryl sulfate or similar anionic surfactants.
The amount of any one or more of the surfactant or foaming agent present in the oral care composition or a component thereof (e.g., hydrophilic phase or hydrophobic phase) can vary widely. In at least one embodiment, any one or more of a surfactant or a foaming agent may be present in the oral care composition or a component thereof in an amount greater than 0.0 wt%, or 0.1 wt% and less than or equal to 10.0 wt%, based on the total weight of the oral care composition or component thereof. For example, any one or more of a surfactant or foaming agent may be present in the oral care composition or a component thereof in an amount of about 0.5 weight%, about 1.0 weight%, about 1.5 weight%, about 2.0 weight%, or about 2.5 weight% to about 3.0 weight%, about 3.5 weight%, about 4.0 weight%, about 4.5 weight%, about 5.0 weight%, or about 10 weight%, based on the total weight of the oral care composition or component thereof. In another example, the surfactant can be present in the oral care composition or component thereof in an amount of from about 0.5 wt% to about 5.0 wt%, from about 1.0 wt% to about 4.5 wt%, from about 1.5 wt% to about 4.0 wt%, from about 2.0 wt% to about 3.5 wt%, or from about 2.5 wt% to about 3.0 wt%, based on the total weight of the oral care composition or component thereof. In exemplary embodiments, any one or more of the surfactants or foaming agents present in the oral care composition or a component thereof may be present in an amount of from about 1 wt% to about 2 wt%, from about 1.25 wt% to about 1.75 wt%, or about 1.5 wt%, based on the total weight of the oral care composition.
Fluoride ion source
In at least one embodiment, the oral care composition can be free or substantially free of fluoride (e.g., soluble fluoride salts). In at least one embodiment, the oral care composition can include fluoride, such as one or more fluoride ion sources (e.g., soluble fluoride salts). A variety of fluoride ion-generating materials may be employed as the soluble fluoride source. Examples of suitable fluoride ion-generating materials can be found in U.S. patent nos. 3,535, 421 to Briner et al, Parran, et al, 4,885, 155 to Widder et al, and 3,678, 154 to Widder et al, the disclosures of which are incorporated herein by reference. Illustrative fluoride ion sources include, but are not limited to, fluoride, stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, fluorosilicates such as sodium fluorosilicate and ammonium fluorosilicate, amine fluoride, ammonium fluoride, and combinations thereof. In typical embodiments, the fluoride ion source comprises sodium monofluorophosphate. The amount of fluoride ion source in the oral care composition can be greater than 0 wt% and less than 0.8 wt%, less than 0.7 wt%, less than 0.6 wt%, less than 0.5 wt%, or less than 0.4 wt%. The fluoride ion source may be present in an amount sufficient to provide a total of about 100 to about 20,000ppm, about 200 to about 5,000ppm, or about 500 to about 2,500ppm of fluoride ions.
Orally acceptable vehicle or carrier
The oral care composition may form at least a part of or be used in one or more oral care products. The oral care composition may include or be combined with an orally acceptable vehicle. For example, the oral care composition may include or be combined with an orally acceptable vehicle to form an oral care product. The orally acceptable vehicle can include any known ingredient or additive. The orally acceptable vehicle can include various dentifrice ingredients to modify the rheology and mouthfeel of the oral care composition.
In at least one embodiment, the orally acceptable vehicle can include one or more humectants. Illustrative humectants can be or include, but are not limited to, glycerin, propylene glycol, polyethylene glycol, and combinations thereof. In a preferred embodiment, the orally acceptable vehicle can be or include, but is not limited to, propylene glycol.
In at least one embodiment, the orally acceptable vehicle can include an orally acceptable solvent. Illustrative solvents may include, but are not limited to, one or more of the following: ethanol, methanol, isopropanol, butanol, water, acetone, methyl ethyl ketone, ethyl acetate, butyl acetate, cyclohexanone, cyclohexane, dichloromethane, chloroform, carbon tetrachloride, trichloroethylene, perchloroethylene, methyl glycol acetate, toluene, benzene, diethyl ether and benzyl alcohol. In a preferred embodiment, the orally acceptable solvent comprises benzyl alcohol.
The orally acceptable vehicle can be present in an amount of from 5% to about 60% by weight, based on the total weight of the oral care composition. For example, the orally acceptable vehicle can be present in an amount of about 5%, about 10%, about 15%, or about 20% to about 25%, about 30%, about 35%, about 40%, about 45%, about 50%, about 55%, or about 60% by weight. In another example, the orally acceptable vehicle can be present in an amount of about 5% to about 60%, about 10% to about 55%, about 15% to about 50%, about 20% to about 25%, about 20% to about 40%, about 20% to about 35%, about 20% to about 30%, or about 20% to about 25% by weight. In exemplary embodiments, the orally acceptable vehicle can be present in an amount of about 20% to about 30% by weight, preferably about 20% to about 25% by weight, and more preferably about 22% to about 25% by weight. In preferred embodiments, the orally acceptable vehicle can be present in an amount of about 22% to about 25% or about 23% by weight.
Thickening system and/or viscosity control agent
The oral care product or oral care composition thereof may include a thickening system having one or more thickening agents. The one or more thickening agents can be any orally acceptable thickening or thickening agent configured to control the viscosity of an oral care product or oral care composition thereof. Illustrative thickening agents can be or include, but are not limited to, colloidal silica, fumed silica, crosslinked polyvinylpyrrolidone (PVP) polymers, crosslinked polyvinylpyrrolidone (PVP), and the like, and mixtures or combinations thereof. In at least one embodiment, the thickening system comprises a crosslinked polyvinylpyrrolidone (PVP) polymer. The thickening system may also include that commercially available from Ashland Inc (Kyoto, KY) of Calwaton, KentuckyXL 10F. Illustrative thickeners may also be or include, but are not limited to, carbomers (e.g., carboxyvinyl polymers), carrageenans (e.g., Irish moss, carrageenan, iota carrageenan, etc.), high molecular weight polyethylene glycols (e.g., commercially available from Dow Chemical Company, Midland, MI, Mich.) and the like) Cellulose polymers, hydroxyethyl cellulose, carboxymethyl cellulose and salts thereof (e.g., CMC sodium), natural gums (e.g., karaya, xanthan, gum arabic, and tragacanth), colloidal magnesium aluminum silicate, and the like, as well as mixtures or combinations thereof.
In more typical embodiments, the thickening system may beIncluding organic polymers, which may also be configured as adhesion enhancers. Illustrative organic polymers can be or include, but are not limited to, hydrophilic polymers, such as carbomers, such as carboxymethylene polymers, such as acrylic acid polymers and acrylic acid copolymers. Carboxypolymethylene is a slightly acidic vinyl polymer having active carboxyl groups. In typical embodiments, the thickening system comprises carboxypolymethylene groups, e.g.974 and/or 980, which are commercially available from nory corporation of Cleveland, OH (Noveon, Inc.).
In at least one embodiment, the thickening system may include a single thickener. For example, the thickening system may comprise a crosslinked polyvinylpyrrolidone (PVP) polymer or an organic polymer (e.g. PVP)). In another embodiment, the thickening system may include a plurality of thickeners. For example, the thickening system may include crosslinked PVP polymers and organic polymers.
The amount or concentration of the thickening system and/or thickening agent thereof present in the oral care composition can vary widely. The thickening system and/or thickening agent thereof may be present in the oral care composition in an amount of from about 1.0 wt% to about 3.0 wt%, based on the total weight of the oral care composition. For example, the thickening system and/or thickening agent thereof may be present in the oral care composition in an amount of about 1 wt%, about 1.1 wt%, about 1.2 wt%, about 1.3 wt%, about 1.4 wt%, about 1.5 wt%, about 1.6 wt%, about 1.7 wt%, about 1.8 wt%, about 1.9 wt%, about 2.0 wt%, or about 2.1 wt% to about 2.2 wt%, about 2.3 wt%, about 2.4 wt%, about 2.5 wt%, about 2.6 wt%, about 2.7 wt%, about 2.8 wt%, about 2.9 wt%, or about 3.0 wt%. In another example, the thickening system and/or thickening agent thereof may be present in the oral care composition in an amount of from about 1.2% to about 3.0%, from about 1.3% to about 2.9%, from about 1.4% to about 2.8%, from about 1.5% to about 2.7%, from about 1.6% to about 2.6%, from about 1.7% to about 2.5%, from about 1.8% to about 2.4%, from about 1.9% to about 2.3%, or from about 2.0% to about 2.2% by weight. In typical embodiments, the thickening system and/or thickening agent thereof may be present in the oral care composition in an amount of from about 1.0 wt% to about 2.0 wt%, more typically from about 1.2 wt% to about 1.8 wt%, and more typically about 1.5 wt%.
pH regulator
The oral care product or oral care composition or components thereof may include one or more pH adjusting agents. For example, the oral care composition may include one or more acidulants and/or one or more alkalizers configured to lower and/or increase its pH, respectively. Illustrative acidifying agent and/or one or more alkalizing agents may be or include, but are not limited to, alkali metal hydroxides such as sodium hydroxide and/or potassium hydroxide, citric acid, hydrochloric acid, and the like, or combinations thereof.
The oral care composition or components thereof may also include one or more buffering agents configured to control or adjust the pH within a predetermined or desired range. Illustrative buffering agents can include, but are not limited to, sodium bicarbonate, sodium phosphate, sodium carbonate, sodium acid pyrophosphate, sodium citrate, and mixtures thereof. The sodium phosphate can include sodium dihydrogen phosphate (NaH)2PO4) Disodium hydrogen phosphate (Na)2HPO4) Trisodium phosphate (Na)3PO4) And mixtures thereof. In typical embodiments, the buffer may be anhydrous disodium hydrogen phosphate or disodium hydrogen phosphate and/or sodium dihydrogen phosphate. In another embodiment, the buffering agent comprises anhydrous disodium hydrogen phosphate or disodium hydrogen phosphate and phosphoric acid (e.g., syrupy phosphoric acid; 85% -food grade).
In at least one embodiment, acidifying, buffering, and/or buffering agents may be included in the oral care composition or components thereof to provide a generally neutral pH or an orally acceptable pH range. In another embodiment, acidifying, buffering, and/or buffering agents can be included in the oral care composition or a component thereof (e.g., the hydrophobic phase and/or the hydrophilic phase), wherein the pH is between 2 to 10, 2 to 8, 3 to 9, 4 to 8, 6 to 10, or 7 to 9. Any additional orally acceptable pH adjusting agent can be used, including, but not limited to, carboxylic acids, phosphoric and sulfonic acids, acid salts (e.g., monosodium citrate, disodium citrate, monosodium malate, etc.), alkali metal hydroxides such as sodium hydroxide, carbonates such as sodium carbonate, bicarbonates, sesquicarbonates, borates, silicates, phosphates (e.g., monosodium phosphate, trisodium phosphate, pyrophosphate salts, etc.), imidazoles, and mixtures thereof. One or more pH adjusting agents may optionally be present in an amount effective to maintain the oral care composition or components thereof within an orally acceptable pH range.
Flavoring agent
The oral care product and/or oral care composition thereof may also include one or more flavoring agents. Illustrative flavoring agents may include, but are not limited to, essential oils and various flavoring aldehydes, esters, alcohols, and the like. Flavoring agents may also include, but are not limited to, sweeteners, sucralose, dextrose, polydextrose, sucrose, maltose, dextrin, dried invert sugar, mannose, xylose, ribose, fructose, levulose, galactose, corn syrup (including high fructose corn syrup and corn syrup solids), partially hydrolyzed starch, hydrogenated starch hydrolysate, sorbitol, mannitol, xylitol, maltitol, isomalt, aspartame, neotame, saccharin and salts thereof (e.g., sodium saccharin), dipeptide-based intense sweeteners, cyclamates, dihydrochalcones, and mixtures thereof. Examples of the essential oils include essential oils of spearmint, peppermint, wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon, lemon, lime, grapefruit, and orange. In another example, the flavoring agents may include menthol, carvone, and anethole. In typical embodiments, the flavoring agents include peppermint and spearmint. In a more typical embodiment, the flavoring agent comprises Firmenich Newman flavoring agent. The amount of flavoring agent in the oral care product and/or oral care composition thereof can be less than 1.0 wt%, less than 0.9 wt%, less than 0.8 wt%, or less than 0.7 wt%. For example, the amount of flavoring agent in the oral care product and/or oral care composition thereof can be from about 0.0 wt% to about 1.0 wt%, from about 0.5 wt% to about 0.9 wt%, from about 0.7 wt% to about 0.8 wt%. In typical embodiments, the amount of flavoring agent in the oral care product and/or oral care composition thereof is from about 0.55 wt% to about 0.70 wt%.
Additional ingredients
One of ordinary skill in the art will appreciate that the oral care product and/or oral care composition thereof may include other additional ingredients/components. For example, the oral care product and/or oral care composition thereof can include anticaries agents, desensitizing agents, viscosity modifiers, diluents, pH modifying agents, humectants, mouth feel agents, sweeteners, flavorants, colorants, preservatives, and the like, as well as combinations and mixtures thereof. It will also be appreciated by those of ordinary skill in the art that while the general attributes of each of the above categories of materials may differ, there may be some common attributes and any given material may serve multiple purposes within two or more of these categories of materials.
In at least one embodiment, the additional ingredients/components may include one or more active materials configured to prevent and/or treat one or more conditions and/or disorders of the oral cavity. For example, the one or more active materials can be configured to prevent and/or treat one or more conditions and/or disorders of the hard and/or soft tissue of the oral cavity. The active material can also be configured to prevent and/or treat one or more physiological disorders and/or conditions, and/or provide aesthetic benefits to the oral cavity.
In at least one embodiment, the oral care product or oral care composition thereof may include an anticalculus agent. Illustrative anticalculus agents may include, but are not limited to, phosphates and polyphosphates (e.g., pyrophosphate), polyaminopropane sulfonic Acid (AMPS), hexametaphosphate, zinc citrate trihydrate, polypeptides, polyolefin sulfonates, polyolefin phosphates, bisphosphonates. In typical embodiments, the anticalculus agent comprises tetrasodium pyrophosphate (TSPP), Sodium Tripolyphosphate (STPP), or a combination thereof.
The oral care product or oral care composition thereof may include an antioxidant. Any orally acceptable antioxidant may be used, including but not limited to: butylated Hydroxyanisole (BHA), Butylated Hydroxytoluene (BHT), vitamin a, carotenoids, vitamin E, flavonoids, polyphenols, ascorbic acid, herbal antioxidants, chlorophyll, melatonin, and the like, and combinations and mixtures thereof.
The oral care composition may include zinc. The zinc of the oral care composition can be or include zinc ions and/or one or more zinc salts. For example, a zinc salt may at least partially dissociate in an aqueous solution to produce zinc ions. Illustrative zinc salts can include, but are not limited to, zinc lactate, zinc oxide, zinc chloride, zinc phosphate, zinc citrate, zinc acetate, zinc borate, zinc butyrate, zinc carbonate, zinc formate, zinc gluconate, zinc glycerate, zinc glycolate, zinc oxide, zinc phosphate, zinc picolinate, zinc propionate, zinc salicylate, zinc silicate, zinc stearate, zinc tartrate, zinc undecylenate, and mixtures thereof. In a preferred embodiment, the zinc salt is zinc lactate.
The oral care composition may include one or more pigments, such as whitening pigments. In some embodiments, the whitening pigment includes particles ranging in size from about 0.1 μm to about 10 μm and having a refractive index greater than about 1.2. Suitable whitening agents include, but are not limited to, titanium dioxide particles, zinc oxide particles, aluminum oxide particles, tin oxide particles, calcium oxide particles, magnesium oxide particles, barium oxide particles, silica particles, zirconium silicate particles, mica particles, talc particles, tetracalcium phosphate particles, amorphous calcium phosphate particles, alpha-tricalcium phosphate particles, beta-tricalcium phosphate particles, hydroxyapatite particles, calcium carbonate particles, zinc phosphate particles, silica particles, zirconium silicate particles, and combinations thereof. The amount of whitening pigment, such as titanium dioxide particles, may be sufficient to whiten the teeth.
Method
The present disclosure can provide methods for treating dentinal hypersensitivity and/or cleaning teeth in a human or animal subject using an oral care product and/or oral care composition thereof. As used herein, "animal subject" can include higher non-human mammals, such as canines, felines, and horses. The method may comprise contacting the oral care product and/or oral care composition thereof with water. The method can further comprise contacting the tooth surface with an oral care product and/or an oral care composition thereof. Contacting the tooth surface with the oral care product and/or oral care composition thereof can include placing the oral care composition (e.g., toothpaste) on a toothbrush and brushing the teeth with the toothbrush.
The oral care product and/or oral care composition thereof may be applied and/or contacted with the tooth surface at predetermined intervals. For example, on a daily basis, at least once per day, twice or more per day for multiple days, or alternatively every other day. In another example, the oral care product and/or whitening composition thereof can be applied and/or contacted with the tooth surface at least once per day, at least once every two days, at least once every three days, at least once every five days, at least once per week, at least once every two weeks, or at least once per month. The oral care product and/or oral care composition thereof may be utilized for up to 2 weeks, up to 3 weeks, up to 4 weeks, up to 6 weeks, up to 8 weeks, or longer.
The present disclosure can also provide methods for preparing oral care compositions having increased foam generation compared to conventional oral care compositions. The method may comprise combining or contacting an orally acceptable vehicle with at least one N-alkyl-N-acylglucamine and optionally at least one additional surfactant or foaming agent. The method can further comprise combining an orally acceptable vehicle and at least one N-alkyl-N-acylglucamine with one or more amino acids and one or more abrasives. For example, the method can include combining an orally acceptable vehicle and at least one N-alkyl-N-acylglucosamine with arginine or a source of arginine and calcium carbonate.
All ingredients used in the compositions described herein should be orally acceptable. As used herein, "orally acceptable" can refer to any ingredient present in a composition as described in an amount and form that does not render the use of the composition unsafe in the oral cavity.
Examples of the invention
The examples and other embodiments described herein are exemplary and are not intended to limit the overall scope of the compositions and methods described herein. Equivalent changes, modifications and variations of specific embodiments, materials, compositions and methods may be made within the scope of the present disclosure, with substantially similar results.
Example 1
The efficacy of different oral care compositions to produce foam was evaluated. Specifically, the control toothpaste composition (C) and six exemplary or test toothpaste compositions (1) - (6) were prepared by combining the ingredients/components of the base toothpaste composition indicated in table 1 with the corresponding surfactants indicated in table 2. The components were mixed for about 10 minutes under mechanical stirring to prepare each of the toothpaste compositions (C) and (1) to (6).
TABLE 1
Base toothpaste composition
TABLE 2
Surfactants were added to the base toothpaste compositions to prepare a control toothpaste composition (C) and exemplary toothpaste compositions (1) - (6)
To evaluate the efficacy of the foam generation, a Kruss dynamic foam analyzer (DFA100) commercially available from Kruss GmbH, Hamburg, Germany was used. The Kruss dynamic foam analyzer was adjusted according to the parameters/test conditions indicated in Table 3.
TABLE 3
Parameters of Kruss dynamic foam analyzer
Parameter(s) | Test conditions |
Concentration of sample | 30% |
Stirring speed | 5,000 RPM |
Interval of oscillation | 6 seconds |
Time of foaming | 60 seconds |
Delay time | 450 seconds |
The results of foam generation are summarized in table 4.
TABLE 4
Overview of foam generation in control toothpaste composition (C) and exemplary toothpaste compositions (1) - (6)
As indicated in table 4, all toothpaste compositions (1) - (6) including either glucamide-8 or glucamide-12 exhibited relatively greater foam generation compared to the control toothpaste composition (C). This finding was both surprising and unexpected because all toothpaste compositions (1) - (6) included relatively lower active foaming agents (i.e., gluconamide-8 or gluconamide-12) as compared to the control toothpaste composition (C). It was further observed that the foam generated or produced in toothpaste compositions (1) - (6) comprising either glucamide-8 or glucamide-12 was relatively denser, richer or more creamy when compared to the control toothpaste composition (C).
The present disclosure has been described with reference to exemplary embodiments. While a limited number of embodiments have been shown and described, it will be appreciated by those skilled in the art that changes may be made in these embodiments without departing from the principles and spirit of the embodiments described previously. It is intended that the disclosure be construed as including all such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (19)
1. An oral care composition, comprising:
an orally acceptable vehicle; and
one or more surfactants, wherein the one or more surfactants comprise an N-alkyl-N-acylglucamine.
2. The oral care composition of claim 1, further comprising an amino acid.
3. The oral care composition of claim 2, wherein the amino acid comprises one or more of: arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutyric acid, diaminopropionic acid, salts thereof, or combinations thereof.
4. The oral care composition of claim 2, wherein the amino acid comprises arginine, optionally the arginine is provided by arginine bicarbonate, further optionally the arginine is provided by arginine bicarbonate solution.
5. The oral care composition of any preceding claim, further comprising an abrasive.
6. The oral care composition according to claim 5, wherein the abrasive comprises one or more of: sodium metaphosphate, potassium metaphosphate, calcium pyrophosphate, magnesium orthophosphate, trimagnesium orthophosphate, tricalcium phosphate, dicalcium phosphate dihydrate, anhydrous dicalcium phosphate, calcium carbonate, magnesium carbonate, hydrated alumina, silica, zirconium silicate, aluminum silicate, calcined aluminum silicate, polymethyl methacrylate, or a combination thereof.
7. The oral care composition according to claim 6, wherein the abrasive comprises calcium carbonate, optionally the calcium carbonate comprises natural calcium carbonate or precipitated calcium carbonate.
9. The oral care composition of any preceding claim, wherein the N-alkyl-N-acylglucamine comprises N-methyl-N-acylglucamine.
10. The oral care composition of any preceding claim, wherein the N-alkyl-N-acylglucamine comprises N-methyl-N-C8-C10-acylglucamine and/or N-methyl-N-C12-C14-an acylglucamine.
11. The oral care composition of any preceding claim, wherein the one or more surfactants further comprise one or more anionic surfactants, one or more nonionic surfactants, one or more cationic surfactants, one or more amphoteric surfactants, one or more zwitterionic surfactants, or a combination thereof.
12. The oral care composition of any preceding claim, wherein the one or more surfactants further comprise an anionic surfactant, optionally the anionic surfactant comprises sodium N-methyl-N-alkyltaurate, optionally the sodium N-methyl-N-alkyltaurate comprises sodium cocoyl methyltaurate and sodium lauroyl methyltaurate.
13. The oral care composition of any preceding claim, wherein the one or more surfactants further comprise a betaine and a sultaine, optionally, the betaine comprises cocamidopropyl betaine.
14. The oral care composition of any preceding claim, wherein the oral care composition is substantially free of sodium lauryl sulfate.
15. The oral care composition of any preceding claim, wherein the oral care composition is a toothpaste.
16. A method for treating or reducing dentinal hypersensitivity in a human, the method comprising contacting the oral care composition of any preceding claim with the tooth surface of the human.
17. The oral care composition according to any one of claims 1 to 16 for use in treating or reducing dentinal hypersensitivity.
18. A method for preparing an oral care composition with increased foam generation, the method comprising combining an orally acceptable vehicle with at least one N-alkyl-N-acylglucamine and optionally at least one additional surfactant or foaming agent.
19. The method of claim 18, further comprising adding one or more amino acids and one or more abrasives to the orally acceptable vehicle and the at least one N-alkyl-N-acylglucamine.
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PCT/US2018/058936 WO2020091805A1 (en) | 2018-11-02 | 2018-11-02 | Oral care compositions comprising n-alkyl-n-acylglucamines |
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CN (1) | CN112867480B (en) |
AU (1) | AU2018448003B2 (en) |
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WO1995023582A1 (en) * | 1994-03-02 | 1995-09-08 | Henkel Kommanditgesellschaft Auf Aktien | Mouth and dental care agents |
WO2017205230A1 (en) * | 2016-05-26 | 2017-11-30 | 3M Innovative Properties Company | Therapeutic dental pastes and related methods and kits |
US20170348550A1 (en) * | 2014-12-26 | 2017-12-07 | Colgate-Palmolive Company | Oral Care Compositions and Methods of Use |
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US6436370B1 (en) * | 1999-06-23 | 2002-08-20 | The Research Foundation Of State University Of New York | Dental anti-hypersensitivity composition and method |
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2018
- 2018-11-02 EP EP18815065.0A patent/EP3856135A1/en active Pending
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- 2018-11-02 WO PCT/US2018/058936 patent/WO2020091805A1/en unknown
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WO1995023582A1 (en) * | 1994-03-02 | 1995-09-08 | Henkel Kommanditgesellschaft Auf Aktien | Mouth and dental care agents |
US20170348550A1 (en) * | 2014-12-26 | 2017-12-07 | Colgate-Palmolive Company | Oral Care Compositions and Methods of Use |
WO2017205230A1 (en) * | 2016-05-26 | 2017-11-30 | 3M Innovative Properties Company | Therapeutic dental pastes and related methods and kits |
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WO2020091805A1 (en) | 2020-05-07 |
AU2018448003B2 (en) | 2021-09-23 |
BR112021007596A2 (en) | 2021-07-27 |
EP3856135A1 (en) | 2021-08-04 |
CA3117941A1 (en) | 2020-05-07 |
BR112021007596B1 (en) | 2024-02-20 |
MX2021004787A (en) | 2021-06-08 |
CN112867480B (en) | 2024-03-26 |
CA3117941C (en) | 2022-10-11 |
AU2018448003A1 (en) | 2021-05-06 |
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