CN112843470A - Implantable closed-loop stimulation method and device - Google Patents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
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- A—HUMAN NECESSITIES
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- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
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- A—HUMAN NECESSITIES
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- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
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Abstract
One or more embodiments of the present specification disclose an implantable closed-loop stimulation method and apparatus, the method comprising: determining the target frequency of the diagnosis and treatment, and judging whether the frequency of the collected bioelectric signals reaches the target frequency and whether the energy of the bioelectric signals exceeds a threshold value; if the judgment result is yes, randomly generating a stimulation signal, and forming a random stimulation sequence based on the target frequency and a preset stimulation ratio, wherein the preset stimulation ratio is the ratio of a stimulation time interval to a non-stimulation time interval; and performing stimulation intervention on the target part based on the stimulation sequence. Like this, can be when detecting that the bioelectricity signal reaches preset random stimulation condition, nimble contact and the stimulation parameter random generation stimulation signal of tolerating according to the patient, this stimulation signal is random generation, and amazing position and intensity all are in the patient tolerates the within range, are showing to have reduced because excessive stimulation is to patient's harmful effects, promote the effect of diagnosing.
Description
Technical Field
The present invention relates to the technical field of medical instruments, and in particular, to an implantable closed-loop stimulation method and device.
Background
At present, implantable medical devices are widely applied to medical clinic to help patients to diagnose and treat diseases. The implanted electric stimulation system mainly comprises an implanted electric pulse generator implanted in a living body, a stimulation electrode and an external controller. The electric stimulation pulse generated by the implanted electric pulse generator is transmitted to the stimulation electrode, and the stimulation electrode electrically stimulates a specific nerve target point, so that diseases such as Parkinson, epilepsy and the like can be diagnosed and treated.
However, for any abnormal electroencephalogram signal detected, a non-differential electrical stimulation intervention is implemented, and it is very easy to damage a functional area of a focus part of a patient due to over-stimulation, so a new diagnosis and treatment stimulation scheme is urgently needed to be found to improve the above defects.
Disclosure of Invention
One or more embodiments of the present disclosure are to provide an implantable closed-loop stimulation method and apparatus, so as to break through an abnormal electroencephalogram loop by using a randomly generated stimulation signal, reduce excessive stimulation applied to abnormal electroencephalograms, and ensure that an implantable diagnosis and treatment scheme is safer and more reliable.
To solve the above technical problem, one or more embodiments of the present specification are implemented as follows:
in a first aspect, an implantable closed-loop stimulation method is provided, comprising:
determining a target frequency of the diagnosis and treatment, wherein the target frequency is a bioelectrical signal frequency reference capable of triggering a stimulation signal;
judging whether the frequency of the collected bioelectric signals reaches the target frequency and whether the energy of the bioelectric signals exceeds a threshold value;
if the judgment result is yes, randomly generating a stimulation signal, and forming a random stimulation sequence based on the target frequency and a preset stimulation ratio, wherein the preset stimulation ratio is the ratio of a stimulation time interval to a non-stimulation time interval;
and performing stimulation intervention on the target part based on the stimulation sequence.
In a second aspect, an implantable closed-loop stimulation device is presented, comprising:
the determination module is used for determining a target frequency of the diagnosis and treatment, wherein the target frequency is a bioelectricity signal frequency reference capable of triggering a stimulation signal;
the judging module is used for judging whether the frequency of the acquired bioelectricity signal reaches the target frequency and whether the energy of the bioelectricity signal exceeds a threshold value;
the processing module is used for randomly generating stimulation signals and forming a random stimulation sequence based on the target frequency and a preset stimulation ratio if the judgment result is yes, wherein the preset stimulation ratio is the ratio of a stimulation time interval to a non-stimulation time interval;
and the stimulation module is used for performing stimulation intervention on the target part based on the stimulation sequence.
In a third aspect, an implantable closed-loop stimulation system is provided, comprising the implantable closed-loop stimulation device.
According to the technical scheme provided by one or more embodiments of the specification, the target frequency of the diagnosis and treatment is determined, wherein the target frequency is a bioelectricity signal frequency reference capable of triggering a stimulation signal; judging whether the frequency of the collected bioelectric signals reaches the target frequency and whether the energy of the bioelectric signals exceeds a threshold value; if the judgment result is yes, randomly generating a stimulation signal, and forming a random stimulation sequence based on the target frequency and a preset stimulation ratio, wherein the preset stimulation ratio is the ratio of a stimulation time interval to a non-stimulation time interval; and performing stimulation intervention on the target part based on the stimulation sequence. Like this, can be when detecting that the bioelectricity signal reaches preset random stimulation condition, nimble contact and the stimulation parameter random generation stimulation signal of tolerating according to the patient, this stimulation signal is random generation, and amazing position and intensity all are in the patient tolerates the within range, are showing to have reduced because excessive stimulation is to patient's harmful effects, promote the effect of diagnosing.
Drawings
In order to more clearly illustrate one or more embodiments or prior art solutions of the present specification, reference will now be made briefly to the attached drawings, which are needed in the description of one or more embodiments or prior art, and it should be apparent that the drawings in the description below are only some of the embodiments described in the specification, and that other drawings may be obtained by those skilled in the art without inventive exercise.
Fig. 1 is a schematic diagram illustrating steps of an implantable closed-loop stimulation method according to an embodiment of the present disclosure.
Fig. 2 is a schematic flowchart of an implantable closed-loop stimulation method provided in an embodiment of the present disclosure.
Fig. 3 is a schematic structural diagram of an implantable closed-loop stimulation device provided in an embodiment of the present disclosure.
Fig. 4 is a schematic structural diagram of an electronic device provided in an embodiment of the present specification.
Detailed Description
In order to make the technical solutions in the present specification better understood, the technical solutions in one or more embodiments of the present specification will be clearly and completely described below with reference to the accompanying drawings in one or more embodiments of the present specification, and it is obvious that the one or more embodiments described are only a part of the embodiments of the present specification, and not all embodiments. All other embodiments that can be derived by a person skilled in the art from one or more of the embodiments described herein without making any inventive step shall fall within the scope of protection of this document.
Example one
Referring to fig. 1, a schematic diagram of steps of an implantable closed-loop stimulation method provided in an embodiment of the present disclosure, the implantable closed-loop stimulation method being suitable for an implantable closed-loop system including at least an implantable device and an extracorporeal device, the method may include the following steps:
step 102: and determining a target frequency of the diagnosis and treatment, wherein the target frequency is a bioelectrical signal frequency reference capable of triggering a stimulation signal.
It should be understood that, in the embodiment of the present specification, in order to accurately and reasonably trigger stimulation, a reference value used in the present medical procedure, that is, the target frequency, needs to be determined before medical treatment. The target frequency may be determined by a doctor user according to empirical data, or may be obtained by learning historical data through a specific algorithm, which is not limited in the embodiments of the present specification.
Step 104: and judging whether the frequency of the acquired bioelectric signal reaches the target frequency and whether the energy of the bioelectric signal exceeds a threshold value.
In fact, when judging whether the abnormal degree of the acquired bioelectric signal reaches the condition that stimulation can be triggered, not only the frequency of the current bioelectric signal but also whether the energy of the current bioelectric signal exceeds the standard needs to be concerned. In this way, the accuracy of the triggering stimulus can be further improved. The threshold is set similarly to the target frequency, as described above with reference to step 102.
Step 106: and if so, randomly generating a stimulation signal, and forming a random stimulation sequence based on the target frequency and a preset stimulation ratio, wherein the preset stimulation ratio is the ratio of a stimulation time interval to a non-stimulation time interval.
Only when the two conditions that the frequency of the current bioelectric signal reaches the target frequency and the energy exceeds the threshold value are met simultaneously, the generation of random stimulation can be triggered. Otherwise, all signals are regarded as normal signals, and no intervention processing is carried out.
It is understood that the stimulation signals described in this specification carry contact information and waveform information; then, step 106, when randomly generating the stimulation signal, specifically performs as: and randomly generating a stimulation signal by adopting a random number generator based on the preset contact set and the preset waveform parameter set.
Wherein the preset set of contacts is determined by:
judging whether the contact contained in the stimulation electrode in the current implantable equipment is tolerant to organisms; if the contact is tolerant, all the tolerant contacts are integrated into a preset contact set; otherwise, no processing is performed.
It is contemplated that the implantable device may have one or more stimulation electrodes, each of which may include one or more contacts, each of which may be positioned at a different location on the lesion of the living being (i.e., the patient). When stimulation signals are applied to all the contacts on all the stimulation electrodes, some parts may not be needed for stimulation, but the undifferentiated stimulation may affect the functional area around the lesion, for example, causing side effects or complications. Therefore, it is necessary to select the patient-tolerant contacts from among the contacts of these stimulation electrodes, and to group them together into a preset set of contacts. It will be appreciated that the contacts in this predetermined set of contacts are able to withstand a greater number and degree of stimulation than are intolerant contacts, thereby reducing the risk of over-stimulation.
The preset waveform parameter set is determined by:
judging whether a stimulation waveform corresponding to waveform parameters which can be used by a stimulation electrode in the current implantable equipment is tolerant to organisms; if the stimulation waveform is tolerant, the waveform parameters corresponding to the tolerant stimulation waveform are integrated into a preset waveform parameter set; otherwise, no processing is performed.
The waveform parameters may include: amplitude, frequency, pulse width, duration, etc. When judging whether the stimulation waveform corresponding to the waveform parameter that can be used by the stimulation electrode in the current implantable device is tolerant to the organism, the following aspects can be referred to:
the range of stimulation parameters that the implantable device can withstand;
the range of stimulation parameters routinely used in clinical medicine;
empirical data of a group of physicians;
historical stimulation data;
factory setting parameter values of the implantable device.
Generally, the above five aspects are considered together, and after the weighted comparison, the waveform parameter set corresponding to the stimulus signal tolerated by the patient is determined. It should be understood that these sets include different ranges of values for different waveform parameters.
After the preset contact set and the preset waveform parameter set tolerated by the patient are determined, the set can be sent to a random number generator to generate a random stimulation signal. In essence, the contact and waveform parameters are randomly combined and then a random stimulus signal is generated according to the randomly combined parameters.
Step 108: and performing stimulation intervention on the target part based on the stimulation sequence.
Specifically, when a stimulation signal in the random stimulation sequence comes, stimulation intervention is carried out on the target part corresponding to the selected contact when the stimulation signal is randomly generated.
Through the technical scheme, the target frequency of the diagnosis and treatment is determined, wherein the target frequency is a bioelectricity signal frequency reference capable of triggering a stimulation signal; judging whether the frequency of the collected bioelectric signals reaches the target frequency and whether the energy of the bioelectric signals exceeds a threshold value; if the judgment result is yes, randomly generating a stimulation signal, and forming a random stimulation sequence based on the target frequency and a preset stimulation ratio, wherein the preset stimulation ratio is the ratio of a stimulation time interval to a non-stimulation time interval; and performing stimulation intervention on the target part based on the stimulation sequence. Like this, can be when detecting that the bioelectricity signal reaches preset random stimulation condition, the contact and the stimulation waveform random generation stimulation signal that the nimble patient of using tolerated, this stimulation signal is random generation, and amazing position and signal patient tolerate, are showing to have reduced because excessive stimulation to patient's harmful effects, promote the effect of diagnosing.
The following takes electroencephalogram signals as an example, and details of the embodiments of the present description are given by using specific flowcharts.
Fig. 2 is a schematic flow chart of an implantable closed-loop stimulation method provided in an embodiment of the present disclosure.
Firstly, a target brain electrical frequency f can be set, when the frequency of the acquired brain electrical signal is more than or equal to the target brain electrical frequency f, whether the energy of the brain electrical signal exceeds a threshold value is further judged, and if yes, a random stimulation sequence is triggered and generated. Otherwise, no processing is performed.
In fact, before this, a set of contacts C ═ { C1_ 1., Cn _ m }, where Cn _ m denotes the mth contact on the nth electrode, may be predetermined. The patient's tolerated contact is judged and the tolerated contact is selected for inclusion in contact set C, while the contact is rejected for intolerance.
Similarly, a stimulation waveform P ═ { P1,.. Pn } is predetermined, where Pn represents a stimulation parameter that the patient tolerates. The patient's tolerated stimulation parameters are determined and selected to be included in the parameter set W. And rejected for intolerant stimulation parameters.
Then, the stimulation parameters in the contact and parameter group W in the contact group C are sent to a random number generator to generate a random stimulation signal S. The random stimulation signal S contains not only the stimulation waveform but also the corresponding contact information.
And finally, combining a preset stimulation ratio K, using a random stimulation signal S to generate a random stimulation sequence Seq ═ f (f, K), and performing random stimulation intervention on a contact corresponding to the random stimulation signal S.
The duration of the random stimulus signal, the total number of random stimulus signals in the random stimulus sequence, is determined by the target frequency f.
Example two
Referring to fig. 3, for the implantable closed-loop stimulation apparatus provided in the embodiments of the present disclosure, the apparatus 300 may include:
a determining module 302, configured to determine a target frequency of the diagnosis and treatment, where the target frequency is a bioelectric signal frequency reference capable of triggering a stimulation signal;
a determining module 304, configured to determine whether the frequency of the acquired bioelectric signal reaches the target frequency, and whether the energy of the bioelectric signal exceeds a threshold;
the processing module 306 is configured to randomly generate a stimulation signal and form a random stimulation sequence based on the target frequency and a preset stimulation ratio if the determination result is yes, where the preset stimulation ratio is a ratio of a stimulation period to a non-stimulation period;
a stimulation module 308 for performing a stimulation intervention on the target site based on the stimulation sequence.
Optionally, as an embodiment, the stimulation signal carries contact information and waveform information;
the processing module 306 is specifically configured to, when randomly generating the stimulation signal:
and randomly generating a stimulation signal by adopting a random number generator based on the preset contact set and the preset waveform parameter set.
In a specific implementation manner of the embodiment of the present specification, the processing module 306, when forming a random stimulation sequence based on the target frequency and a preset stimulation ratio, is specifically configured to:
determining the duration of the random stimulation sequence based on the target frequency;
and forming a random stimulation sequence according to a preset stimulation ratio in the duration.
In another specific implementation manner of the embodiment of the present specification, the preset contact set is determined by:
judging whether the contact contained in the stimulation electrode in the current implantable equipment is tolerant to organisms;
if the contact is tolerant, all the tolerant contacts are integrated into a preset contact set;
otherwise, no processing is performed.
In another specific implementation manner of the embodiment of the present specification, the preset waveform parameter set is determined by:
judging whether a stimulation waveform corresponding to waveform parameters which can be used by a stimulation electrode in the current implantable equipment is tolerant to organisms;
if the stimulation waveform is tolerant, the waveform parameters corresponding to the tolerant stimulation waveform are integrated into a preset waveform parameter set;
otherwise, no processing is performed.
In a further specific implementation manner of the embodiments of the present specification, the stimulation module, when performing stimulation intervention on the target site based on the random stimulation sequence, is specifically configured to:
and when the stimulation signals in the random stimulation sequence arrive, carrying out stimulation intervention on the target part corresponding to the selected contact when the stimulation signals are randomly generated.
Through the technical scheme, the target frequency of the diagnosis and treatment is determined, wherein the target frequency is a bioelectricity signal frequency reference capable of triggering a stimulation signal; judging whether the frequency of the collected bioelectric signals reaches the target frequency and whether the energy of the bioelectric signals exceeds a threshold value; if the judgment result is yes, randomly generating a stimulation signal, and forming a random stimulation sequence based on the target frequency and a preset stimulation ratio, wherein the preset stimulation ratio is the ratio of a stimulation time interval to a non-stimulation time interval; and performing stimulation intervention on the target part based on the stimulation sequence. Like this, can be when detecting that the bioelectricity signal reaches preset random stimulation condition, the contact and the stimulation waveform random generation stimulation signal that the nimble patient of using tolerated, this stimulation signal is random generation, and amazing position and signal patient tolerate, are showing to have reduced because excessive stimulation to patient's harmful effects, promote the effect of diagnosing.
EXAMPLE III
Embodiments of the present disclosure also provide an implantable closed-loop stimulation system including the implantable closed-loop stimulation device. In addition, the system may also include extracorporeal devices, as well as other existing accessories or modules.
Through the technical scheme, the target frequency of the diagnosis and treatment is determined, wherein the target frequency is a bioelectricity signal frequency reference capable of triggering a stimulation signal; judging whether the frequency of the collected bioelectric signals reaches the target frequency and whether the energy of the bioelectric signals exceeds a threshold value; if the judgment result is yes, randomly generating a stimulation signal, and forming a random stimulation sequence based on the target frequency and a preset stimulation ratio, wherein the preset stimulation ratio is the ratio of a stimulation time interval to a non-stimulation time interval; and performing stimulation intervention on the target part based on the stimulation sequence. Like this, can be when detecting that the bioelectricity signal reaches preset random stimulation condition, the contact and the stimulation waveform random generation stimulation signal that the nimble patient of using tolerated, this stimulation signal is random generation, and amazing position and signal patient tolerate, are showing to have reduced because excessive stimulation to patient's harmful effects, promote the effect of diagnosing.
Example four
Fig. 4 is a schematic structural diagram of an electronic device according to an embodiment of the present disclosure. Referring to fig. 4, at a hardware level, the electronic device includes a processor, and optionally further includes an internal bus, a network interface, and a memory. The Memory may include a Memory, such as a Random-Access Memory (RAM), and may further include a non-volatile Memory, such as at least 1 disk Memory. Of course, the electronic device may also include hardware required for other services.
The processor, the network interface, and the memory may be connected to each other via an internal bus, which may be an ISA (Industry Standard Architecture) bus, a PCI (Peripheral Component Interconnect) bus, an EISA (Extended Industry Standard Architecture) bus, or the like. The bus may be divided into an address bus, a data bus, a control bus, etc. For ease of illustration, only one double-headed arrow is shown in FIG. 4, but that does not indicate only one bus or one type of bus.
And the memory is used for storing programs. In particular, the program may include program code comprising computer operating instructions. The memory may include both memory and non-volatile storage and provides instructions and data to the processor.
The processor reads a corresponding computer program from the non-volatile memory into the memory and then runs the computer program to form the implantable closed-loop stimulation device on a logical level. The processor is used for executing the program stored in the memory and is specifically used for executing the following operations:
determining a target frequency of the diagnosis and treatment, wherein the target frequency is a bioelectrical signal frequency reference capable of triggering a stimulation signal;
judging whether the frequency of the collected bioelectric signals reaches the target frequency and whether the energy of the bioelectric signals exceeds a threshold value;
if the judgment result is yes, randomly generating a stimulation signal, and forming a random stimulation sequence based on the target frequency and a preset stimulation ratio, wherein the preset stimulation ratio is the ratio of a stimulation time interval to a non-stimulation time interval;
and performing stimulation intervention on the target part based on the stimulation sequence.
The method performed by the apparatus according to the embodiment shown in fig. 1 of the present specification may be implemented in or by a processor. The processor may be an integrated circuit chip having signal processing capabilities. In implementation, the steps of the above method may be performed by integrated logic circuits of hardware in a processor or instructions in the form of software. The Processor may be a general-purpose Processor, including a Central Processing Unit (CPU), a Network Processor (NP), and the like; but also Digital Signal Processors (DSPs), Application Specific Integrated Circuits (ASICs), Field Programmable Gate Arrays (FPGAs) or other Programmable logic devices, discrete Gate or transistor logic devices, discrete hardware components. The methods, steps, and logic blocks disclosed in one or more embodiments of the present specification may be implemented or performed. A general purpose processor may be a microprocessor or the processor may be any conventional processor or the like. The steps of a method disclosed in connection with one or more embodiments of the present disclosure may be embodied directly in hardware, in a software module executed by a hardware decoding processor, or in a combination of the hardware and software modules executed by a hardware decoding processor. The software module may be located in ram, flash memory, rom, prom, or eprom, registers, etc. storage media as is well known in the art. The storage medium is located in a memory, and a processor reads information in the memory and completes the steps of the method in combination with hardware of the processor.
The electronic device may also execute the method of fig. 1 and implement the functions of the corresponding apparatus in the embodiment shown in fig. 1, which are not described herein again in this specification.
Of course, besides the software implementation, the electronic device of the embodiment of the present disclosure does not exclude other implementations, such as a logic device or a combination of software and hardware, and the like, that is, the execution subject of the following processing flow is not limited to each logic unit, and may also be hardware or a logic device.
Through the technical scheme, the target frequency of the diagnosis and treatment is determined, wherein the target frequency is a bioelectricity signal frequency reference capable of triggering a stimulation signal; judging whether the frequency of the collected bioelectric signals reaches the target frequency and whether the energy of the bioelectric signals exceeds a threshold value; if the judgment result is yes, randomly generating a stimulation signal, and forming a random stimulation sequence based on the target frequency and a preset stimulation ratio, wherein the preset stimulation ratio is the ratio of a stimulation time interval to a non-stimulation time interval; and performing stimulation intervention on the target part based on the stimulation sequence. Like this, can be when detecting that the bioelectricity signal reaches preset random stimulation condition, the contact and the stimulation waveform random generation stimulation signal that the nimble patient of using tolerated, this stimulation signal is random generation, and amazing position and signal patient tolerate, are showing to have reduced because excessive stimulation to patient's harmful effects, promote the effect of diagnosing.
EXAMPLE five
Embodiments of the present specification also propose a computer-readable storage medium storing one or more programs, the one or more programs comprising instructions, which when executed by a portable electronic device comprising a plurality of application programs, are capable of causing the portable electronic device to perform the method of the embodiment shown in fig. 1, and in particular for performing the method of:
determining a target frequency of the diagnosis and treatment, wherein the target frequency is a bioelectrical signal frequency reference capable of triggering a stimulation signal;
judging whether the frequency of the collected bioelectric signals reaches the target frequency and whether the energy of the bioelectric signals exceeds a threshold value;
if the judgment result is yes, randomly generating a stimulation signal, and forming a random stimulation sequence based on the target frequency and a preset stimulation ratio, wherein the preset stimulation ratio is the ratio of a stimulation time interval to a non-stimulation time interval;
and performing stimulation intervention on the target part based on the stimulation sequence.
Through the technical scheme, the target frequency of the diagnosis and treatment is determined, wherein the target frequency is a bioelectricity signal frequency reference capable of triggering a stimulation signal; judging whether the frequency of the collected bioelectric signals reaches the target frequency and whether the energy of the bioelectric signals exceeds a threshold value; if the judgment result is yes, randomly generating a stimulation signal, and forming a random stimulation sequence based on the target frequency and a preset stimulation ratio, wherein the preset stimulation ratio is the ratio of a stimulation time interval to a non-stimulation time interval; and performing stimulation intervention on the target part based on the stimulation sequence. Like this, can be when detecting that the bioelectricity signal reaches preset random stimulation condition, the contact and the stimulation waveform random generation stimulation signal that the nimble patient of using tolerated, this stimulation signal is random generation, and amazing position and signal patient tolerate, are showing to have reduced because excessive stimulation to patient's harmful effects, promote the effect of diagnosing.
In short, the above description is only a preferred embodiment of the present disclosure, and is not intended to limit the scope of the present disclosure. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present specification shall be included in the protection scope of the present specification.
The system, apparatus, module or unit illustrated in one or more of the above embodiments may be implemented by a computer chip or an entity, or by an article of manufacture with a certain functionality. One typical implementation device is a computer. In particular, the computer may be, for example, a personal computer, a laptop computer, a cellular telephone, a camera phone, a smartphone, a personal digital assistant, a media player, a navigation device, an email device, a game console, a tablet computer, a wearable device, or a combination of any of these devices.
Computer-readable media, including both non-transitory and non-transitory, removable and non-removable media, may implement information storage by any method or technology. The information may be computer readable instructions, data structures, modules of a program, or other data. Examples of computer storage media include, but are not limited to, phase change memory (PRAM), Static Random Access Memory (SRAM), Dynamic Random Access Memory (DRAM), other types of Random Access Memory (RAM), Read Only Memory (ROM), Electrically Erasable Programmable Read Only Memory (EEPROM), flash memory or other memory technology, compact disc read only memory (CD-ROM), Digital Versatile Discs (DVD) or other optical storage, magnetic cassettes, magnetic tape magnetic disk storage or other magnetic storage devices, or any other non-transmission medium that can be used to store information that can be accessed by a computing device. As defined herein, a computer readable medium does not include a transitory computer readable medium such as a modulated data signal and a carrier wave.
It should also be noted that the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other like elements in a process, method, article, or apparatus that comprises the element.
The embodiments in the present specification are described in a progressive manner, and the same and similar parts among the embodiments are referred to each other, and each embodiment focuses on the differences from the other embodiments. In particular, for the system embodiment, since it is substantially similar to the method embodiment, the description is simple, and for the relevant points, reference may be made to the partial description of the method embodiment.
The foregoing description has been directed to specific embodiments of this disclosure. Other embodiments are within the scope of the following claims. In some cases, the actions or steps recited in the claims may be performed in a different order than in the embodiments and still achieve desirable results. In addition, the processes depicted in the accompanying figures do not necessarily require the particular order shown, or sequential order, to achieve desirable results. In some embodiments, multitasking and parallel processing may also be possible or may be advantageous.
Claims (10)
1. An implantable closed-loop stimulation method, comprising:
determining a target frequency of the diagnosis and treatment, wherein the target frequency is a bioelectrical signal frequency reference capable of triggering a stimulation signal;
judging whether the frequency of the collected bioelectric signals reaches the target frequency and whether the energy of the bioelectric signals exceeds a threshold value;
if the judgment result is yes, randomly generating a stimulation signal, and forming a random stimulation sequence based on the target frequency and a preset stimulation ratio, wherein the preset stimulation ratio is the ratio of a stimulation time interval to a non-stimulation time interval;
and performing stimulation intervention on the target part based on the stimulation sequence.
2. The implantable closed-loop stimulation method of claim 1, wherein the stimulation signal carries contact information and waveform information;
randomly generating a stimulation signal, specifically comprising:
and randomly generating a stimulation signal by adopting a random number generator based on the preset contact set and the preset waveform parameter set.
3. The implantable closed-loop stimulation method of claim 2, wherein the set of preset contacts is determined by:
judging whether the contact contained in the stimulation electrode in the current implantable equipment is tolerant to organisms;
if the contact is tolerant, all the tolerant contacts are integrated into a preset contact set;
otherwise, no processing is performed.
4. The implantable closed-loop stimulation method of claim 2, wherein the preset waveform parameter set is determined by:
judging whether a stimulation waveform corresponding to waveform parameters which can be used by a stimulation electrode in the current implantable equipment is tolerant to organisms;
if the stimulation waveform is tolerant, the waveform parameters corresponding to the tolerant stimulation waveform are integrated into a preset waveform parameter set;
otherwise, no processing is performed.
5. The implantable closed-loop stimulation method according to any one of claims 1-4, wherein forming a random stimulation sequence based on the target frequency and a preset stimulation ratio comprises:
determining the duration of the random stimulation sequence based on the target frequency;
and forming a random stimulation sequence according to a preset stimulation ratio in the duration.
6. The implantable closed-loop stimulation method according to claim 5, wherein the performing stimulation intervention on the target site based on the random stimulation sequence specifically comprises:
and when the stimulation signals in the random stimulation sequence arrive, carrying out stimulation intervention on the target part corresponding to the selected contact when the stimulation signals are randomly generated.
7. An implantable closed loop stimulation device, comprising:
the determination module is used for determining a target frequency of the diagnosis and treatment, wherein the target frequency is a bioelectricity signal frequency reference capable of triggering a stimulation signal;
the judging module is used for judging whether the frequency of the acquired bioelectricity signal reaches the target frequency and whether the energy of the bioelectricity signal exceeds a threshold value;
the processing module is used for randomly generating stimulation signals and forming a random stimulation sequence based on the target frequency and a preset stimulation ratio if the judgment result is yes, wherein the preset stimulation ratio is the ratio of a stimulation time interval to a non-stimulation time interval;
and the stimulation module is used for performing stimulation intervention on the target part based on the stimulation sequence.
8. The implantable closed-loop stimulation device of claim 7, wherein the stimulation signal carries contact information and waveform information;
the processing module, when randomly generating the stimulation signal, is specifically configured to:
and randomly generating a stimulation signal by adopting a random number generator based on the preset contact set and the preset waveform parameter set.
9. The implantable closed-loop stimulation device according to claim 7 or 8, wherein the processing module, when forming the random stimulation sequence based on the target frequency and a preset stimulation ratio, is specifically configured to:
determining the duration of the random stimulation sequence based on the target frequency;
and forming a random stimulation sequence according to a preset stimulation ratio in the duration.
10. An implantable closed-loop stimulation system, comprising an implantable closed-loop stimulation device according to any of claims 7-9.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2201980A1 (en) * | 2008-12-23 | 2010-06-30 | St. Jude Medical AB | Implantable tissue stimulator |
| CN103501855A (en) * | 2011-04-20 | 2014-01-08 | 美敦力公司 | Electrical therapy parameter determination based on a bioelectrical resonance response |
| CN104203338A (en) * | 2012-01-30 | 2014-12-10 | 艾奥华大学研究基金会 | Managing back pain by applying a high frequency electrical stimulus directly to the spinal cord |
| US20160175594A1 (en) * | 2014-12-19 | 2016-06-23 | Pacesetter, Inc. | System and method to control dorsal root stimulation parameters based on frequency decomposition |
| US20190151657A1 (en) * | 2017-11-17 | 2019-05-23 | Boston Scientific Neuromodulation Corporation | Systems and methods for generating intermittent stimulation using electrical stimulation systems |
-
2021
- 2021-02-05 CN CN202110163722.9A patent/CN112843470A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2201980A1 (en) * | 2008-12-23 | 2010-06-30 | St. Jude Medical AB | Implantable tissue stimulator |
| CN103501855A (en) * | 2011-04-20 | 2014-01-08 | 美敦力公司 | Electrical therapy parameter determination based on a bioelectrical resonance response |
| CN104203338A (en) * | 2012-01-30 | 2014-12-10 | 艾奥华大学研究基金会 | Managing back pain by applying a high frequency electrical stimulus directly to the spinal cord |
| US20160175594A1 (en) * | 2014-12-19 | 2016-06-23 | Pacesetter, Inc. | System and method to control dorsal root stimulation parameters based on frequency decomposition |
| US20190151657A1 (en) * | 2017-11-17 | 2019-05-23 | Boston Scientific Neuromodulation Corporation | Systems and methods for generating intermittent stimulation using electrical stimulation systems |
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