CN112842686A - Microneedle device for treating age-related macular degeneration - Google Patents
Microneedle device for treating age-related macular degeneration Download PDFInfo
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- CN112842686A CN112842686A CN202110164361.XA CN202110164361A CN112842686A CN 112842686 A CN112842686 A CN 112842686A CN 202110164361 A CN202110164361 A CN 202110164361A CN 112842686 A CN112842686 A CN 112842686A
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- 206010064930 age-related macular degeneration Diseases 0.000 title claims abstract description 19
- 208000002780 macular degeneration Diseases 0.000 title claims abstract description 19
- 239000003814 drug Substances 0.000 claims abstract description 27
- 239000007788 liquid Substances 0.000 claims abstract description 20
- 239000007924 injection Substances 0.000 claims abstract description 9
- 238000002347 injection Methods 0.000 claims abstract description 9
- 239000011324 bead Substances 0.000 claims description 16
- 230000000149 penetrating effect Effects 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 5
- 239000012530 fluid Substances 0.000 claims description 2
- 208000024304 Choroidal Effusions Diseases 0.000 abstract description 6
- 238000012377 drug delivery Methods 0.000 abstract description 4
- 210000003786 sclera Anatomy 0.000 abstract description 3
- 230000000694 effects Effects 0.000 description 9
- 229940079593 drug Drugs 0.000 description 8
- 238000005457 optimization Methods 0.000 description 7
- 208000012886 Vertigo Diseases 0.000 description 4
- 230000005540 biological transmission Effects 0.000 description 4
- 231100000889 vertigo Toxicity 0.000 description 4
- 230000000007 visual effect Effects 0.000 description 4
- 230000007774 longterm Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 230000002411 adverse Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000003889 eye drop Substances 0.000 description 2
- 229940012356 eye drops Drugs 0.000 description 2
- 230000001960 triggered effect Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00736—Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00861—Methods or devices for eye surgery using laser adapted for treatment at a particular location
- A61F2009/00865—Sclera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00885—Methods or devices for eye surgery using laser for treating a particular disease
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- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention provides a microneedle device for treating age-related macular degeneration, which comprises a hollow microneedle, a cylinder and a driver, wherein a base is arranged in the cylinder in a sliding manner, and the hollow microneedle is connected with the base; the rear end of the base is enlarged and is contacted with the inner wall of the cylinder, and a rack is arranged in the middle of the base and is connected with a power mechanism arranged in the cylinder; the driver is used for controlling the injection of the liquid medicine through the hollow microneedle. The invention injects the micro-needle into the sclera and injects the liquid medicine, and the liquid medicine enters the suprachoroidal space of the eye through the inserted micro-needle to realize the delivery of the medicine; microneedles enable precise drug delivery into the suprachoroidal space for subsequent local delivery to nearby tissues in need of treatment; in addition, the invention also adjusts the extending long section of the hollow microneedle by arranging the matching of the power mechanism and the rack on the base, thereby being capable of accurately controlling the depth of the microneedle inserted into the eye tissue.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to a microneedle device for treating age-related macular degeneration.
Background
Age related macular degeneration requires long-term drug therapy. However, in the current medical field, drug delivery to the eye and its difficulties, especially high molecular delivery and delivery to the back of the eye, are encountered.
There are generally two ways to deliver drugs to the eye: 1. delivery using eye drops, while they can be used to treat conditions affecting the outer surface of the eye or tissues in the front of the eye, eye drops do not penetrate behind the eye in large quantities; 2. direct injection into the eye using conventional needles and syringes, while relatively effective for delivering drugs to the posterior segment of the eye, requires specialized training and poses safety concerns.
Therefore, it is a technical problem to be solved by those skilled in the art how to provide a microneedle device for treating age-related macular degeneration, which has a simple structure and a good sealing effect.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides a microneedle device for treating age-related macular degeneration, which comprises:
the front end of the hollow microneedle is a tip, a pinhole penetrating through two ends of the hollow microneedle is arranged in the hollow microneedle, and the pinhole is used for transmitting liquid medicine;
the back end of the hollow microneedle extends into the barrel and is connected with the front end of the base, a base hole penetrating through the front and back of the base is formed in the base, and the front end of the base hole is opposite to a pinhole of the hollow microneedle; the rear end of the base is enlarged and is in contact with the inner wall of the barrel, a rack is arranged in the middle of the base and is connected with a power mechanism arranged in the barrel;
a driver for controlling injection of a medical fluid through the hollow microneedle.
The application realizes the delivery of the drug by injecting the micro-needle into the sclera and injecting the drug liquid, wherein the drug liquid enters the suprachoroidal space of the eye through the inserted micro-needle; microneedles enable precise drug delivery into the suprachoroidal space for subsequent local delivery to nearby tissues in need of treatment; in addition, this application still adjusts the long section that hollow micropin stretches out through the cooperation that sets up power unit and the rack on the base to the depth that can accurate control micropin inserted eye tissue.
As optimization, the power mechanism comprises a box body, and a motor, an input worm wheel, an output worm wheel shaft and a helical gear which are arranged in the box body;
an output shaft of the motor extends along the radial direction of the barrel and is connected with an input worm extending along the radial direction of the barrel, the input worm is meshed with an input turbine, the input turbine is coaxially connected with an output worm extending along the axial direction of the barrel, the output worm is meshed with an output turbine extending along the axial direction of the barrel, the output turbine is coaxially connected with an output turbine shaft extending along the radial direction of the barrel, and one end of the output turbine shaft is provided with the helical gear;
an outlet for the extending of the helical gear is formed in the position, corresponding to the helical gear, on one side of the box body close to the rack, and the part, extending out of the box body, of the helical gear is meshed with the rack on the base.
Therefore, the technical scheme realizes the adjustment of the extension length of the hollow microneedle by adopting the lifting of the worm gear and the worm, and can meet the requirement of long-term use; in addition, because the worm gear self structure of this application possesses self-locking function, can make and stop behind the hollow micropin depths arbitrary length and directly pin, made things convenient for more to carry out the work of delivering the medicine to the eye.
Preferably, the driver comprises a handle body and a conduit, the handle body is arranged along the axial direction in a hollow mode, one end of the conduit is communicated with the rear end of the barrel, and the other end of the conduit is communicated with the front end of the handle body;
the handle body is internally provided with a piston rod, the front end of the piston rod is provided with a piston cap, the rear end of the piston rod is connected with a pressing rod, the pressing rod is sleeved with a spring, the front end of the spring is connected with the rear end of the piston rod, and the rear end of the spring is connected with a pushing piece.
In the application, the liquid medicine can be configured in a space between the piston cap in the handle body and the front end of the handle body, and the driving force is provided by applying force to the pushing piece, so that the liquid medicine passes through the catheter and the hollow microneedle to complete injection; specifically, when this application is to the impeller application of force, the spring is continuously compressed, until pressing the push rod and impeller contact, because the elasticity of spring is fixed, then the pressure of pressing the piston rod this moment also be fixed, controllable, through selecting for use the spring of different elasticity, can realize different downforce to the piston rod, like this, can the transmission volume of accurate control liquid medicine to adapt to different patients.
As optimization, the pushing piece comprises a switch module, a metering module, an indicator lamp module and a power supply module;
the switch module is used for sending a starting signal to the metering module when detecting that the acting force of the spring on the piston rod reaches a preset numerical value, and sending a stopping signal to the metering module when detecting that the acting force of the spring on the piston rod does not reach the preset numerical value;
the metering module meters the delivered liquid medicine by timing; after receiving a starting signal sent by the switch module, the metering module starts timing and sends a starting signal to the indicator light module; when the preset time is reached, the metering module sends a stop signal to the indicator light module;
the indicating lamp module sends a signal to the outside by turning on or off an indicating lamp of the indicating lamp module according to the received signal of the metering module;
the power module is used for supplying power to the switch module, the metering module and the indicator light module.
Like this, can tell medical personnel whether need continue the operation through the pilot lamp for medical personnel can accurate control the duration of exerting pressure, have improved the injection effect, and it is simple and understandable, make and can comparatively easily train medical personnel.
As optimization, the switch module is arranged at the front part of the pushing piece, the front end of the switch module is provided with a pressure sensor, and the rear end of the spring is connected with the pressure sensor;
when the pressure sensor detects that the pressure of the spring reaches a preset value, the switch module sends a starting signal to the metering module; when the pressure sensor detects that the pressure of the spring does not reach a preset value, the switch module sends a stop signal to the metering module;
the switch module is provided with a pressing switch corresponding to the position of the pressing rod, the switch module sends a starting signal to the metering module when the end of the pressing rod presses the pressing switch, and the switch module sends a stopping signal to the metering module when the end of the pressing rod is far away from the pressing switch.
In the application, the medical staff continuously presses the pushing piece to compress the spring until the pressing rod on the piston rod is contacted with the press switch and triggers the press switch, and after the press switch is triggered, the switch module sends a timing starting signal to the metering module.
As an optimization, the indicator light module comprises a light source structure and a light-transmitting structure;
the lamp source structure comprises a mounting box arranged on the inner wall of the handle body, an integrated circuit board is mounted in the mounting box, and a plurality of LED lamp beads are arranged on the integrated circuit board; the mounting box is annular as a whole, and a light outlet is formed in one side of the mounting box, which faces the inner wall of the handle body;
the light-transmitting structure is annular and forms a part of the side wall of the handle body, and a light outlet of the mounting box is opposite to the light-transmitting structure; wherein, the light-transmitting structure is protruded towards the outer side of the handle body to form a light-transmitting ring.
The applicant finds that the indicator lamp is directly additionally arranged on the handle body, so that the adverse effect of visual vertigo is easily caused to medical staff, and the analysis shows that: the poor effect of visual vertigo is caused by uneven brightness of the light-transmitting part due to high brightness of the aperture surface close to the light source and low brightness of the aperture surface far from the light source in the light-transmitting part because the conduction efficiency of the handle body is extremely low; in the application, the handle body is provided with the light-transmitting structure, and the light-transmitting structure is protruded outwards to form a light-transmitting ring, so that the light-transmitting part forms a circle, and the uniformity of the brightness is improved.
As an optimization, a light-passing board is arranged between the LED lamp beads and the light-passing structure, light collecting grooves are formed in the light-passing board, the light collecting grooves are of groove structures of cones, and the LED lamp beads are located in the light collecting grooves.
Like this, this application has designed the light-collecting groove of cone structure, and LED lamp pearl is located this light-collecting groove, and the light-collecting groove just can surround the light that LED lamp pearl sent completely to absorbed the most luminous energy of LED lamp pearl, the light energy that has significantly reduced spills over, has improved the leaded light efficiency of light-passing board department, further realizes that light-passing structure's luminance is even.
Preferably, the diameter of one side of the light collecting groove close to the LED lamp bead is larger than that of one side close to the light transmitting structure.
Thus, the effect of absorbing light energy can be more effectively achieved.
As optimization, the LED lamp beads comprise red lamps and green lamps, and after the metering module starts timing, the green lamps are normally on and the red lamps are turned off; and after the metering module reaches the preset time, the green light and the red light are normally on.
Thus, the medical staff can judge whether to continue the operation or not by the indicating lamp more clearly.
Preferably, the light-transmitting structure is a member made of a PC material.
Therefore, the PC material has high conductive efficiency, reduces the transmission consumption of light energy and is beneficial to improving the brightness uniformity of the light-transmitting structure.
Drawings
In order to more clearly illustrate the embodiments of the present invention, the drawings, which are required to be used in the embodiments, will be briefly described below. In all the drawings, the elements or parts are not necessarily drawn to actual scale.
Fig. 1 is a schematic structural view of a microneedle device for treating age-related macular degeneration according to the present invention;
fig. 2 is a schematic structural diagram of the power mechanism of the present invention in a top view;
FIG. 3 is a schematic view of the structure of the pusher and piston rod of the present invention;
fig. 4 is a schematic structural view of the mounting box of the present invention.
Reference numerals:
1-hollow microneedles; 2-a cylinder body;
3-driver, 31-handle, 32-conduit, 33-piston rod, 331-piston cap, 34-pressing rod, 35-spring;
4-base, 41-rack;
5-a power mechanism, 50-a box body, 51-a motor, 52-an input worm, 53-an input turbine, 54-an output worm, 55-an output turbine, 56-an output turbine shaft and 57-a helical gear;
6-a pushing piece, 61-a pressing switch, 62-a light source structure, 621-a mounting box, 622-an integrated circuit board, 623-an LED lamp bead, 63-a light-transmitting structure, 64-a light-transmitting plate and 640-a light-collecting groove.
Detailed Description
Embodiments of the present invention will be described in detail below with reference to the accompanying drawings. The following examples are only for illustrating the technical solutions of the present invention more clearly, and therefore are only examples, and the protection scope of the present invention is not limited thereby.
Example (b): as shown in fig. 1, a microneedle device for treating age-related macular degeneration includes a hollow microneedle 1, a cylinder 2 and an actuator 3. The front end of the hollow microneedle 1 is a tip, and a pinhole penetrating through two ends of the hollow microneedle 1 is arranged in the hollow microneedle 1 and is used for transferring liquid medicine. A base 4 is arranged in the barrel 2 in a sliding mode, the rear end of the hollow microneedle 1 extends into the barrel 2 and is connected with the front end of the base 4, a base hole penetrating through the front and the rear of the base is formed in the base 4, and the front end of the base hole is opposite to a pinhole of the hollow microneedle 1; wherein, the rear end of the base 4 is expanded and contacts with the inner wall of the cylinder 2, the middle part of the base 4 is provided with a rack 41, and the rack 41 is connected with a power mechanism 5 arranged in the cylinder 2. The driver 3 is used for controlling the injection of the liquid medicine through the hollow microneedle 1.
The application realizes the delivery of the drug by injecting the micro-needle into the sclera and injecting the drug liquid, wherein the drug liquid enters the suprachoroidal space of the eye through the inserted micro-needle; microneedles enable precise drug delivery into the suprachoroidal space for subsequent local delivery to nearby tissues in need of treatment; in addition, this application still adjusts the long section that hollow micropin stretches out through the cooperation that sets up power unit and the rack on the base to the depth that can accurate control micropin inserted eye tissue.
As shown in fig. 1 and 2, the power mechanism 5 includes a housing 50, and a motor 51, an input worm 52, an input worm wheel 53, an output worm 54, an output worm wheel 55, an output turbine shaft 56, and a helical gear 57 disposed in the housing 50.
Specifically, as shown in fig. 1 and 2, the output shaft of the motor 51 extends in the radial direction of the cylinder 2 and is connected to an input worm 52 extending in the radial direction of the cylinder 2, the input worm 52 is meshed with an input worm wheel 53, the input worm wheel 53 is coaxially connected to an output worm 54 extending in the axial direction of the cylinder 2, the output worm 54 is meshed with an output worm wheel 55 extending in the axial direction of the cylinder 2, the output worm wheel 55 is coaxially connected to an output turbine shaft 56 extending in the radial direction of the cylinder 2, and one end of the output turbine shaft 56 is provided with the helical gear 57. An outlet for the helical gear 57 to extend out is formed in a position, corresponding to the helical gear 57, on one side of the box body 50 close to the rack 41, and a part of the helical gear 57 extending out of the box body 50 is meshed with the rack 41 on the base 4.
Therefore, the technical scheme realizes the adjustment of the extension length of the hollow microneedle by adopting the lifting of the worm gear and the worm, and can meet the requirement of long-term use; in addition, because the worm gear self structure of this application possesses self-locking function, can make and stop behind the hollow micropin depths arbitrary length and directly pin, made things convenient for more to carry out the work of delivering the medicine to the eye.
As shown in fig. 1 and 3, the driver 3 includes a handle 31 and a conduit 32, the handle 31 is disposed along an axial direction, one end of the conduit 32 is communicated with a rear end of the barrel 2, and the other end of the conduit 32 is communicated with a front end of the handle 31. The handle body 31 is internally provided with a piston rod 33, the front end of the piston rod 33 is provided with a piston cap 331, the rear end of the piston rod 33 is connected with a pressing rod 34, the pressing rod 34 is sleeved with a spring 35, the front end of the spring 35 is connected with the rear end of the piston rod 33, and the rear end of the spring 35 is connected with a pushing piece 6.
In the application, the liquid medicine can be configured in a space between the piston cap in the handle body and the front end of the handle body, and the driving force is provided by applying force to the pushing piece, so that the liquid medicine passes through the catheter and the hollow microneedle to complete injection; specifically, when this application is to the impeller application of force, the spring is continuously compressed, until pressing the push rod and impeller contact, because the elasticity of spring is fixed, then the pressure of pressing the piston rod this moment also be fixed, controllable, through selecting for use the spring of different elasticity, can realize different downforce to the piston rod, like this, can the transmission volume of accurate control liquid medicine to adapt to different patients.
As shown in fig. 1 and 3, the pushing member 6 includes a switch module, a metering module, an indicator light module, and a power supply module.
The switch module is used for sending a start signal to the metering module when detecting that the acting force of the spring 35 on the piston rod 33 reaches a preset value, and sending a stop signal to the metering module when detecting that the acting force of the spring 35 on the piston rod 33 does not reach the preset value.
The metering module meters the delivered liquid medicine by timing; after receiving a starting signal sent by the switch module, the metering module starts timing and sends a starting signal to the indicator light module; and when the preset duration is reached, the metering module sends a stop signal to the indicator lamp module.
And the indicating lamp module lights or extinguishes the indicating lamp of the indicating lamp module to send a signal outwards according to the received signal of the metering module.
The power module is used for supplying power to the switch module, the metering module and the indicator light module.
Like this, can tell medical personnel whether need continue the operation through the pilot lamp for medical personnel can accurate control the duration of exerting pressure, have improved the injection effect, and it is simple and understandable, make and can comparatively easily train medical personnel.
As shown in fig. 1 and 3, the switch module is disposed in front of the pushing member 6, a pressure sensor is disposed at a front end of the switch module, and a rear end of the spring 35 is connected to the pressure sensor. When the pressure sensor detects that the pressure of the spring 35 reaches a preset value, the switch module sends a starting signal to the metering module; when the pressure sensor detects that the pressure of the spring 35 does not reach a preset value, the switch module sends a stop signal to the metering module.
As shown in fig. 1 and 3, a push switch 61 is provided at a position corresponding to the push rod 34 on the switch module, the switch module transmits a start signal to the metering module when the end of the push rod 34 pushes the push switch 61, and the switch module transmits a stop signal to the metering module when the end of the push rod 34 is away from the push switch 61.
In the application, the medical staff continuously presses the pushing piece to compress the spring until the pressing rod on the piston rod is contacted with the press switch and triggers the press switch, and after the press switch is triggered, the switch module sends a timing starting signal to the metering module.
As shown in fig. 1 and 4, the indicator light module includes a light source structure 62 and a light transmitting structure 63.
The lamp source structure 62 comprises a mounting box 621 arranged on the inner wall of the handle body 31, an integrated circuit board 622 is mounted in the mounting box 621, and a plurality of LED lamp beads 623 are arranged on the integrated circuit board 622. The mounting box 621 is annular, and a light outlet is formed in one side of the mounting box 621 facing the inner wall of the handle body 31. The light-transmitting structure 63 is annular and forms a part of the sidewall of the handle body 31, and the light outlet of the mounting box 621 is opposite to the light-transmitting structure 63. The light-transmitting structure 63 also protrudes to the outside of the handle body 31 to form a light-transmitting ring.
The applicant finds that the indicator lamp is directly additionally arranged on the handle body, so that the adverse effect of visual vertigo is easily caused to medical staff, and the analysis shows that: the poor effect of visual vertigo is caused by uneven brightness of the light-transmitting part due to high brightness of the aperture surface close to the light source and low brightness of the aperture surface far from the light source in the light-transmitting part because the conduction efficiency of the handle body is extremely low; in the application, the handle body is provided with the light-transmitting structure, and the light-transmitting structure is protruded outwards to form a light-transmitting ring, so that the light-transmitting part forms a circle, and the uniformity of the brightness is improved.
As an optimization, as shown in fig. 1 and 4, a light-transmitting plate 64 is arranged between the LED lamp bead 623 and the light-transmitting structure 63, the light-transmitting plate 64 is provided with a light-collecting groove 640, the light-collecting groove 640 is formed into a groove structure of a cone, and the LED lamp bead 623 is located in the light-collecting groove 640. The diameter of one side of the light collecting groove 640 close to the LED lamp bead 623 is larger than that of one side close to the light-transmitting structure 63. Thus, the effect of absorbing light energy can be more effectively achieved.
Like this, this application has designed the light-collecting groove of cone structure, and LED lamp pearl is located this light-collecting groove, and the light-collecting groove just can surround the light that LED lamp pearl sent completely to absorbed the most luminous energy of LED lamp pearl, the light energy that has significantly reduced spills over, has improved the leaded light efficiency of light-passing board department, further realizes that light-passing structure's luminance is even.
As shown in fig. 4, the LED lamp bead 623 includes a red lamp and a green lamp, and after the metering module starts timing, the green lamp is turned on and the red lamp is turned off; and after the metering module reaches the preset time, the green light and the red light are normally on.
Thus, the medical staff can judge whether to continue the operation or not by the indicating lamp more clearly.
As shown in fig. 1, the light-transmitting structure 63 is a member made of PC material.
Therefore, the PC material has high conductive efficiency, reduces the transmission consumption of light energy and is beneficial to improving the brightness uniformity of the light-transmitting structure.
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the present invention, and they should be construed as being included in the following claims and description.
Claims (10)
1. A microneedle device for treatment of age-related macular degeneration, comprising:
the front end of the hollow microneedle is a tip, a pinhole penetrating through two ends of the hollow microneedle is arranged in the hollow microneedle, and the pinhole is used for transmitting liquid medicine;
the back end of the hollow microneedle extends into the barrel and is connected with the front end of the base, a base hole penetrating through the front and back of the base is formed in the base, and the front end of the base hole is opposite to a pinhole of the hollow microneedle; the rear end of the base is enlarged and is in contact with the inner wall of the barrel, a rack is arranged in the middle of the base and is connected with a power mechanism arranged in the barrel;
a driver for controlling injection of a medical fluid through the hollow microneedle.
2. The microneedle device for age related macular degeneration treatment according to claim 1, wherein the power mechanism includes a case, and a motor, an input worm wheel, an output turbine shaft, and a helical gear provided in the case;
an output shaft of the motor extends along the radial direction of the barrel and is connected with an input worm extending along the radial direction of the barrel, the input worm is meshed with an input turbine, the input turbine is coaxially connected with an output worm extending along the axial direction of the barrel, the output worm is meshed with an output turbine extending along the axial direction of the barrel, the output turbine is coaxially connected with an output turbine shaft extending along the radial direction of the barrel, and one end of the output turbine shaft is provided with the helical gear;
an outlet for the extending of the helical gear is formed in the position, corresponding to the helical gear, on one side of the box body close to the rack, and the part, extending out of the box body, of the helical gear is meshed with the rack on the base.
3. The microneedle device for age related macular degeneration treatment as set forth in claim 1, wherein said actuator comprises a handle body and a guide tube, said handle body is disposed along an axial hollow, one end of said guide tube is communicated with a rear end of the cylinder body, and the other end of the guide tube is communicated with a front end of the handle body;
the handle body is internally provided with a piston rod, the front end of the piston rod is provided with a piston cap, the rear end of the piston rod is connected with a pressing rod, the pressing rod is sleeved with a spring, the front end of the spring is connected with the rear end of the piston rod, and the rear end of the spring is connected with a pushing piece.
4. The microneedle device for age related macular degeneration treatment according to claim 3, wherein the pushing member includes a switch module, a metering module, an indicator lamp module, and a power supply module;
the switch module is used for sending a starting signal to the metering module when detecting that the acting force of the spring on the piston rod reaches a preset numerical value, and sending a stopping signal to the metering module when detecting that the acting force of the spring on the piston rod does not reach the preset numerical value;
the metering module meters the delivered liquid medicine by timing; after receiving a starting signal sent by the switch module, the metering module starts timing and sends a starting signal to the indicator light module; when the preset time is reached, the metering module sends a stop signal to the indicator light module;
the indicating lamp module sends a signal to the outside by turning on or off an indicating lamp of the indicating lamp module according to the received signal of the metering module;
the power module is used for supplying power to the switch module, the metering module and the indicator light module.
5. The microneedle device for age-related macular degeneration treatment according to claim 4, wherein the switch module is disposed in front of the pushing member, a pressure sensor is disposed at a front end of the switch module, and a rear end of the spring is connected to the pressure sensor;
when the pressure sensor detects that the pressure of the spring reaches a preset value, the switch module sends a starting signal to the metering module; when the pressure sensor detects that the pressure of the spring does not reach a preset value, the switch module sends a stop signal to the metering module;
the switch module is provided with a pressing switch corresponding to the position of the pressing rod, the switch module sends a starting signal to the metering module when the end of the pressing rod presses the pressing switch, and the switch module sends a stopping signal to the metering module when the end of the pressing rod is far away from the pressing switch.
6. The microneedle device for age related macular degeneration treatment according to claim 4, wherein the indicator lamp module includes a lamp source structure and a light transmitting structure;
the lamp source structure comprises a mounting box arranged on the inner wall of the handle body, an integrated circuit board is mounted in the mounting box, and a plurality of LED lamp beads are arranged on the integrated circuit board; the mounting box is annular as a whole, and a light outlet is formed in one side of the mounting box, which faces the inner wall of the handle body;
the light-transmitting structure is annular and forms a part of the side wall of the handle body, and a light outlet of the mounting box is opposite to the light-transmitting structure; wherein, the light-transmitting structure is protruded towards the outer side of the handle body to form a light-transmitting ring.
7. The microneedle device for treating age related macular degeneration according to claim 6, wherein a light-transmitting plate is arranged between the LED lamp beads and the light-transmitting structure, the light-transmitting plate is provided with light-collecting grooves, the light-collecting grooves are formed into a groove structure of a cone, and the LED lamp beads are located in the light-collecting grooves.
8. The microneedle device for age related macular degeneration treatment according to claim 7, wherein a diameter of a side of the light collecting groove near the LED lamp bead is larger than a diameter of a side near the light transmitting structure.
9. The microneedle device for treating age related macular degeneration according to claim 6, wherein the LED lamp beads include a red lamp and a green lamp, and after the metering module starts timing, the green lamp is turned on and the red lamp is turned off; and after the metering module reaches the preset time, the green light and the red light are normally on.
10. The microneedle device for age related macular degeneration treatment according to claim 6, wherein the light transmitting structure is a member made of a PC material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110164361.XA CN112842686A (en) | 2021-02-05 | 2021-02-05 | Microneedle device for treating age-related macular degeneration |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110164361.XA CN112842686A (en) | 2021-02-05 | 2021-02-05 | Microneedle device for treating age-related macular degeneration |
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| Publication Number | Publication Date |
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| CN112842686A true CN112842686A (en) | 2021-05-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202110164361.XA Pending CN112842686A (en) | 2021-02-05 | 2021-02-05 | Microneedle device for treating age-related macular degeneration |
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Application publication date: 20210528 |