CN112812729A - Preparation method of hydrogel for scar film - Google Patents
Preparation method of hydrogel for scar film Download PDFInfo
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- CN112812729A CN112812729A CN202110217106.7A CN202110217106A CN112812729A CN 112812729 A CN112812729 A CN 112812729A CN 202110217106 A CN202110217106 A CN 202110217106A CN 112812729 A CN112812729 A CN 112812729A
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J175/00—Adhesives based on polyureas or polyurethanes; Adhesives based on derivatives of such polymers
- C09J175/04—Polyurethanes
- C09J175/08—Polyurethanes from polyethers
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/48—Polyethers
- C08G18/4804—Two or more polyethers of different physical or chemical nature
- C08G18/482—Mixtures of polyethers containing at least one polyether containing nitrogen
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/48—Polyethers
- C08G18/4829—Polyethers containing at least three hydroxy groups
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/48—Polyethers
- C08G18/4833—Polyethers containing oxyethylene units
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/48—Polyethers
- C08G18/50—Polyethers having heteroatoms other than oxygen
- C08G18/5021—Polyethers having heteroatoms other than oxygen having nitrogen
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/83—Chemically modified polymers
- C08G18/837—Chemically modified polymers by silicon containing compounds
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- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a preparation method of a water gel for a scar film, which relates to the field of water gels and comprises the following steps: step A: in a closed nitrogen environment, mixing hydrophobic polyol and hydrophilic diisocyanate, and stirring for reaction to obtain a first prepolymer; and B: adding a cross-linking agent into the first prepolymer in a closed nitrogen environment, stirring for reaction, and cross-linking to obtain a second prepolymer; and C: and adding a silane compound into the second prepolymer in a closed nitrogen environment, and stirring for reaction to end-cap the second prepolymer to obtain the water gel for the scar film. Step D: the hydrogel can be further added as follows: carboxymethyl 32406vitamin (CMC), powder, 32406vitamin, sodium alginate … and other water-absorbing materials to obtain the functional water-based adhesive for scar adhesive sheet of the present example, the water-based adhesive for scar adhesive sheet of the present invention is obtained by reacting a hydrophobic polyol with a hydrophilic diisocyanate and partially crosslinking and sealing the reaction product, has good water-absorbing properties, is air-permeable, has appropriate moisture retention and peel strength, effectively blocks ultraviolet light penetration and inhibits bacteria, and has significant effects on wound healing and scar formation reduction.
Description
Technical Field
The invention relates to the field of water gel, in particular to a preparation method of water gel for scar films.
Background
The existing nursing patches for removing scars usually use silicone gel (silicone gel) dressing patches or Polyurethane (PU) dressings, which have a fixed supporting effect on wounds and can prevent water and have a good moisturizing effect.
However, the existing silicone gel dressing patch has low air permeability (less than 400g/m2/day), is easy to cause wound infiltration to slow wound healing and also is easy to prevent sweat from evaporating and dissipating heat to cause allergy, and the existing polyurethane dressing patch has no obvious effect on reducing scar formation.
Disclosure of Invention
The invention aims to provide a preparation method of the water gel for the scar film, which has good air permeability, proper moisture retention and peeling strength, can effectively block ultraviolet light from penetrating and inhibiting bacteria, and has obvious effects on wound healing and scar generation reduction.
The technical scheme adopted by the invention for solving the technical problems is as follows: the preparation method of the hydrocolloid for the scar film comprises the following steps:
step A: mixing hydrophobic or hydrophilic polyol and hydrophobic or hydrophilic diisocyanate in a molar ratio of 1: 1-1: 10 in a closed nitrogen environment, and stirring for reaction to obtain a first prepolymer;
and B: adding a cross-linking agent into the first prepolymer according to a molar ratio of 2: 0.1-2: 1 in a closed nitrogen environment, stirring for reaction, and cross-linking to obtain a second prepolymer;
and C: and adding a silane compound into the second prepolymer in a molar ratio of 1: 0.1-1: 1 in a closed nitrogen environment, stirring for reaction, and sealing the end of the second prepolymer to obtain the water gel for the scar film.
Further, the method comprises the following steps: the hydrophobic polyol is prepared by the following steps:
a 1: in a closed nitrogen environment, mixing branched polyol with a molar ratio of 1: 2-1: 4 with first diisocyanate, adding a catalyst for reaction to obtain a triisocyanate intermediate, wherein the polyol is diol-hexahydric alcohol.
a 2: in a closed nitrogen environment, mixing a triisocyanate intermediate and hydrophobic or hydrophilic polyether polyol in a molar ratio of 1: 2-1: 4, adding a catalyst, and stirring for reaction to obtain the hydrophobic polyol.
Further, the method comprises the following steps: the hydrophilic or hydrophobic diisocyanate is obtained by reacting hydrophilic polyether polyol and second diisocyanate in a molar ratio of 1: 1-1: 3.
Further, the method comprises the following steps: the molar ratio of the cross-linking agent to the first prepolymer is in a range of 0.2-0.4: 2, and the content of the crosslinking agent cannot be 0.
Further, the method comprises the following steps: and C, mixing the hydrophobic or hydrophilic polyol and the hydrophilic or hydrophobic diisocyanate in the step A at the temperature of 80 ℃ for 90 min.
Further, the method comprises the following steps: and B, mixing the first prepolymer and the cross-linking agent in the step B at the temperature of 80 ℃ for 90 min.
Further, the method comprises the following steps: the branched polyol in step a1 was mixed with the first diisocyanate at a temperature of 80 ℃ for a reaction time of 90 min.
Further, the method comprises the following steps: the temperature of mixing the triisocyanate intermediate and the hydrophobic or hydrophilic polyether polyol in the step a2 is 80 ℃, and the reaction time is 90 min.
The invention has the beneficial effects that: the water gel for the scar film is obtained by reacting hydrophobic polyol with hydrophilic diisocyanate and performing partial cross-linking and end capping, has good air permeability, proper moisture retention and peeling strength, can effectively block ultraviolet light from penetrating and inhibiting bacteria, and has obvious effects on wound healing and scar generation reduction.
Detailed Description
The present invention will be further described with reference to the following embodiments.
The preparation method of the hydrocolloid for the scar film comprises the following steps:
step A: mixing hydrophobic or hydrophilic polyol and hydrophobic or hydrophilic diisocyanate in a molar ratio of 1: 1-1: 10 in a closed nitrogen environment, and stirring for reaction to obtain a first prepolymer;
and B: and adding a cross-linking agent into the first prepolymer according to a molar ratio of 2: 0.1-2: 1 in a closed nitrogen environment, stirring for reaction, and crosslinking to obtain a second prepolymer, wherein the cross-linking agent is polyether diamine, the polyether diamine cross-linking agent can be polyethylene glycol diamine (PEG), polypropylene glycol diamine (PPDA) or a combination thereof, and the weight average molecular weight of the second prepolymer is 30,000-60,000 g/mol.
And C: adding a silane compound into the second prepolymer in a molar ratio of 1: 0.1-1: 1 in a closed nitrogen environment, stirring and reacting to seal the end of the second prepolymer, wherein the silane compound is an amino silane, and the amino silane compound can be (aminoalkyl) alkoxy silane (aminoalkyl alkoxysilane), trialkyl silane (aminoalkyl trisalkylsilane) or a combination thereof, so as to obtain the water gel for the scar film.
Based on the above, the aminosilane compound may be (3-aminopropyl) triethoxysilane [ (3-aminopropyl) triethoxy silane, APTES ], (3-aminopropyl) trimethoxysilane [ (3-aminopropyl) triethoxy silane, APTMS ], (3-aminopropyl) diethoxymethylsilane [ (3-aminopropyl) diethoxymethylsilane, APDEMS ], or a combination thereof.
On the basis of the above, the hydrophobic polyol is prepared by the following steps:
a 1: in a closed nitrogen environment, mixing branched polyol with a molar ratio of 1: 2-1: 4 with first diisocyanate, adding a catalyst for reaction to obtain a triisocyanate intermediate;
the branched triol may be 1,1, 1-Trimethylolpropane (TMP), triethanolamine (triethanolamine), glycerol (glycerol), 1,2,6-hexanetriol (1,2,6-hexanetriol), 1,2,4-butanetriol (1,2,4-butanetriol), polyoxyethylene glycerol ether (glycerol ethoxylate), or a combination thereof.
The first diisocyanate may be Hexamethylene Diisocyanate (HDI), methylene dicyclohexyl diisocyanate (H12 MDI), isophorone diisocyanate (IPDI), or a combination thereof.
a 2: mixing a triisocyanate intermediate and hydrophobic or hydrophilic polyether polyol in a molar ratio of 1: 2-1: 4 in a closed nitrogen environment, adding a catalyst, and stirring to react to obtain the hydrophobic polyol, wherein the hydrophobic polyether triol can be polypropylene glycol triol, polytetramethylene ether glycol triol or a combination thereof.
On the basis, the hydrophilic or hydrophobic diisocyanate is obtained by reacting hydrophilic polyether glycol and second diisocyanate in a molar ratio of 1: 1-1: 3, and the hydrophilic polyether glycol is polyethylene glycol.
On the basis, the molar ratio of the cross-linking agent to the first prepolymer is in the range of 0.2-0.4: 2, and the content of the crosslinking agent cannot be 0.
On the basis, the temperature of the hydrophobic or hydrophilic polyol and the hydrophilic or hydrophobic diisocyanate in the step A is 80 ℃, and the reaction time is 90 min.
On the basis, the temperature of the first prepolymer and the cross-linking agent in the step B is 80 ℃, and the reaction time is 90 min.
On the basis of the above, the temperature of the mixing of the branched polyol and the first diisocyanate in the step a1 is 80 ℃, and the reaction time is 90 min.
On the basis of the above, the temperature of mixing the triisocyanate intermediate and the hydrophobic or hydrophilic polyether polyol in the step a2 is 80 ℃, and the reaction time is 90 min.
The first embodiment is as follows:
the preparation method of the hydrocolloid for the scar film comprises the following steps:
step a 1:1, 1, 1-Trimethylolpropane (TMP) and Hexamethylene Diisocyanate (HDI) are mixed in a molar ratio of 1:3 and 0.05 wt% of Triethylenediamine (TEDA) (the total weight of TMP and HDI is 100 wt%) as a catalyst, stirring and reacting at 80 ℃ for 90min, monitoring the disappearance of the NCO characteristic peak at a wave number of 2270cm-1 by FT-IR to obtain a triisocyanate intermediate;
step a 2: the triisocyanate intermediate was reacted with polypropylene glycol triol (PPG 4000triol) in a molar ratio of 1:3 and 0.05 wt% of TEDA (total weight of the triisocyanate and the PPG triol is 100 wt%) as a catalyst, stirring and reacting at 80 ℃ for 90min, and monitoring the extinction of an NCO characteristic peak at a wave number of 2270cm-1 by using FT-IR to obtain a hydrophobic polyol having six hydroxyl groups;
step b: in a closed nitrogen environment, polyethylene glycol (PEG 1000diol) and HDI were mixed in a molar ratio of 1:2 and 0.05 wt% of TEDA (100 wt% based on the total weight of PEG diol and HDI) as a catalyst was added, the reaction was stirred at 80 ℃ for 90min, and the disappearance of the NCO characteristic peak at a wave number of 2270cm-1 was monitored by FT-IR to obtain a hydrophilic diisocyanate;
step A: in a closed nitrogen environment, mixing hydrophobic polyol and hydrophilic diisocyanate in a molar ratio of 1: 6, stirring and reacting for 90min at 80 ℃, and monitoring the extinction of an NCO characteristic peak at a wave number of 2270cm < -1 > by utilizing FT-IR so as to obtain a first prepolymer containing six isocyanate groups per molecule;
and B: in a closed nitrogen atmosphere, in a first prepolymer, in a molar ratio of 2: 0.2 polyethylene glycol diamine (PEG diamine 5000) was added as a crosslinking agent, and the reaction was stirred at 80 ℃ for 90 minutes, followed by monitoring the disappearance of the NCO characteristic peak at 2270cm-1 in wave number by FT-IR to crosslink the mixture to obtain a second prepolymer containing a plurality of isocyanate groups, which had a weight-average molecular weight of 52000g/mol in this example.
And C: in a closed nitrogen atmosphere, in the second prepolymer, the molar ratio of 1: (3-aminopropyl) triethoxysilane (APTES) was added in a ratio of 0.8, the reaction was stirred at 80 ℃ for 90min to cap the second prepolymer, and the disappearance of the NCO characteristic peak at a wavenumber of 2270cm-1 was monitored by FT-IR to obtain the present hydrocolloid.
Step D: carboxymethyl cellulose (CMC) was added to the present hydrocolloid to obtain a functional hydrogel for scar film of this example.
Example two:
the preparation method of the hydrocolloid for the scar film comprises the following steps:
step a 1: in a closed nitrogen environment, triethanolamine and methylene dicyclohexyl diisocyanate are mixed in a molar ratio of 1:2 and 0.05 wt% of Triethylenediamine (TEDA) (the total weight of TMP and HDI is 100 wt%) as a catalyst, stirring and reacting at 80 ℃ for 90min, monitoring the disappearance of the NCO characteristic peak at a wave number of 2270cm-1 by FT-IR to obtain a triisocyanate intermediate;
step a 2: reacting the triisocyanate intermediate with polytetramethylene ether glycol triol in a molar ratio of 1:4, and 0.05 wt% of TEDA (total weight of the triisocyanate and the PPG triol is 100 wt%) is added as a catalyst, the reaction is stirred at 80 ℃ for 90min, and the disappearance of the NCO characteristic peak at a wave number of 2270cm-1 is monitored by FT-IR to obtain a hydrophobic polyol having six hydroxyl groups;
step b: polyethylene glycol (PEG 1000diol) and hexamethylene diisocyanate were mixed in a molar ratio of 1:3 and 0.05 wt% of TEDA (100 wt% based on the total weight of PEG diol and HDI) as a catalyst was added, the reaction was stirred at 80 ℃ for 90min, and the disappearance of the NCO characteristic peak at a wave number of 2270cm-1 was monitored by FT-IR to obtain a hydrophilic diisocyanate;
step A: in a closed nitrogen environment, mixing hydrophobic polyol and hydrophilic diisocyanate in a molar ratio of 1:4, stirring and reacting for 90min at 80 ℃, and monitoring the extinction of an NCO characteristic peak at a wave number of 2270cm < -1 > by utilizing FT-IR so as to obtain a first prepolymer containing six isocyanate groups per molecule;
and B: in a closed nitrogen atmosphere, in a first prepolymer, in a molar ratio of 2: adding polypropylene glycol diamine as a cross-linking agent in a ratio of 0.5, stirring and reacting at 80 ℃ for 90min, monitoring the extinction of an NCO characteristic peak at a wave number of 2270cm < -1 > by utilizing FT-IR, and cross-linking to obtain a second prepolymer containing a plurality of isocyanate groups;
and C: in a closed nitrogen atmosphere, in the second prepolymer, the molar ratio of 1: (3-aminopropyl) trimethoxysilane was added in a proportion of 0.5, the reaction was stirred at 80 ℃ for 90 minutes to cap the second prepolymer, and the disappearance of the NCO characteristic peak at a wavenumber of 2270cm-1 was monitored by FT-IR to obtain the hydrocolloid.
Step D: starch was added to this hydrocolloid to obtain a functional hydrocolloid for scar sheets of this example.
And (3) testing:
the scar film obtained in the embodiment of the invention is coated with the water gel into a water gel patch for the scar film with the thickness of 0.6mm by a coating machine, and the following moisture penetration rate test, peeling strength test and ultraviolet light penetration rate test are carried out.
Testing the water vapor penetration rate:
the moisture permeability of the hydrogel patch for scar film of the embodiment of the invention is tested according to DIN EN 13726-2(2002), the test result is 800-1500 g/m2/day, which shows that the hydrogel patch has good air permeability and proper moisture retention, and can avoid wound infiltration.
And (3) testing the peel strength:
the hydrogel patch for scar film according to the example of the present invention was tested for peel strength according to ASTM D3330-2017, and the test result was 450g/25mm, which showed sufficient adhesion to the skin at the wound site and did not stick to the skin excessively upon peeling so as not to cause noticeable pain.
Ultraviolet light transmittance test:
the ultraviolet light (380nm) penetration rate of the hydrogel patch for the scar film provided by the embodiment of the invention is tested, the test result is less than 10%, and the test result shows that the hydrogel patch can effectively block the ultraviolet light penetration and has the potential of reducing skin pigmentation.
And (3) bacteriostatic test:
10 pieces (n ═ 10) of 0.6g scar film of the first example were sterilized with a water gel and gauze by gamma ray (dose: 15 to 20kGy), and then 10mL of Tris-buffered saline (TBS, 20mM Tris, 150mM NaCl, 0.05% Tween-20, pH 7.4) containing a bacterial solution of Escherichia coli (E.coli, ATCC 35218), Pseudomonas aeruginosa (P.aeruginosa, ATCC 27853) and Staphylococcus aureus (S.aureus, ATCC 25923) of 0.5McFarland standard was added thereto, and the mixture was cultured at 37 ℃ and 220rpm for 2 hours. The buffer solutions before and after the incubation were measured by a turbidimeter and converted into the number of bacteria per ml, and the average results are shown in Table 1 below.
[ TABLE 1 ]
As can be seen from table 1, the numbers of bacteria per ml after the aqueous gel for scar films, escherichia coli, pseudomonas aeruginosa and staphylococcus aureus are respectively cultured are all significantly reduced compared with those before the culture, and the numbers of bacteria per ml after the gauze, the escherichia coli, the pseudomonas aeruginosa and the staphylococcus aureus are respectively cultured are not significantly reduced, which shows that the aqueous gel for scar films can effectively inhibit the growth of the escherichia coli, the pseudomonas aeruginosa and the staphylococcus aureus.
[ wound healing test ]:
A. experimental animals:
the s.d. rats used in the following experiments were female Sprague-Dawley (s.d.) rats (5-12 weeks old, body weight >120g, not pregnant). All experimental animals were housed in a separately air-conditioned animal room maintained at room temperature of 22. + -. 3 ℃ and a relative humidity of 30-70%, and water and feed were sufficiently supplied and freely taken out. Before the experiment, animals need to be quarantined, domesticated and marked with a dye, and healthy individuals are selected by qualified personnel and are randomly divided into an experimental group, a control group 1 and a control group 2.
B. Sterilization of the dressing patch:
the scar films obtained in the above examples were sterilized with a water gel patch (3 cm. times.3 cm, thickness of 0.5mm), a silicone gel (silicone gel) dressing patch CICA-CARE (3 cm. times.3 cm) commercially available from Smith & Nephew and a Polyurethane (PU) dressing patch S2-001(3 cm. times.3 cm) commercially available from Tyl by gamma radiation (dose of 35kGy), and then were taken for the following experiments.
C. Formation of skin wound (skin wound):
the dorsal part (dorsal part) of the s.d. rats was shaved (shaving) and then disinfected with 75% alcohol (disinfected). Thereafter, after anesthesia with isoflurane (isoflurane), a skin wound having an area size of about 2cm × 2cm was cut on the back of the s.d. rat using a sterile surgical scissors and a blade.
D. Application of dressing patch:
the skin wounds of s.d. rats (n ═ 12) of the experimental group, control group 1 and control group 2 were applied with the sterilized hydrogel patch for scar film, commercially available silicone gel dressing patch and commercially available polyurethane dressing patch prepared according to item B above, respectively, and the dressing patches were fixed with an air-permeable elastic bandage. The experiment was conducted for a total of 21 days, and at 7, 4 and 21 days after application of the dressing, skin wounds of 3 of the s.d. rats of each group were photographed, respectively, and skin wounds of other s.d. rats of each group were replaced with new dressing patches, and wound areas were calculated with ImageJ software, and the average results are respectively shown in table 2 below.
[ TABLE 2 ]
As can be seen from table 2, on day 21 after the application of the dressing patch, the skin wound area of the s.d. rat to which the hydrogel patch for scar film of the example of the present invention was applied was significantly reduced, while the skin wound area of the s.d. rat to which the commercially available silicone gel dressing patch was applied and the s.d. rat to which the commercially available polyurethane dressing patch was applied were significantly reduced at a slower rate, showing that the hydrogel patch for scar film of the example of the present invention has a more significant contribution to wound healing than the commercially available silicone gel dressing patch and the commercially available polyurethane dressing patch.
[ scar evaluation test ]:
after healing of the skin wound of the s.d. rats (at day 24 after application of the dressing patch) according to item D of the above [ wound healing test ], the pigmentation (pigmentation), flexibility (pliability), height (height), and vascular proliferation (vascularity) of the skin wound scar of the remaining 3 s.d. rats of each group were evaluated according to the wincony scar scale (VSS), respectively, and the average results were respectively shown in table 3 below.
[ TABLE 3 ]
As can be seen from table 3, the scores of pigmentation, flexibility, height, and vascular proliferation of the scar of the skin wound of the s.d. rats to which the hydrogel for scar film of the example of the present invention was applied were lower than those of the skin wound of the commercially available silicone gel dressing patches and those of the commercially available polyurethane dressing patches after the skin wound of the s.d. rats was healed, showing that the hydrogel for scar film of the example of the present invention had better effects of reducing the generation of the scar than those of the commercially available silicone gel dressing patches and the commercially available polyurethane dressing patches.
The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention in further detail, and it should be understood that the above-mentioned embodiments are only exemplary embodiments of the present invention, and are not intended to limit the present invention, and any modifications, equivalents, improvements and the like made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (8)
1. The preparation method of the hydrocolloid for the scar film is characterized by comprising the following steps: the method comprises the following steps:
step A: mixing hydrophobic or hydrophilic polyol and hydrophobic or hydrophilic diisocyanate in a molar ratio of 1: 1-1: 10 in a closed nitrogen environment, and stirring for reaction to obtain a first prepolymer;
and B: adding a cross-linking agent into the first prepolymer according to a molar ratio of 2: 0.1-2: 1 in a closed nitrogen environment, stirring for reaction, and cross-linking to obtain a second prepolymer;
and C: and adding a silane compound into the second prepolymer in a molar ratio of 1: 0.1-1: 1 in a closed nitrogen environment, stirring for reaction, and sealing the end of the second prepolymer to obtain the water gel for the scar film.
2. The method for preparing the hydrogel for scar film according to claim 1, wherein the method comprises the following steps: the hydrophobic polyol is prepared by the following steps:
a 1: in a closed nitrogen environment, mixing branched polyol with a molar ratio of 1: 2-1: 4 with first diisocyanate, adding a catalyst for reaction to obtain a triisocyanate intermediate;
a 2: in a closed nitrogen environment, mixing a triisocyanate intermediate and hydrophobic or hydrophilic polyether polyol in a molar ratio of 1: 2-1: 4, adding a catalyst, and stirring for reaction to obtain the hydrophobic polyol.
3. The method for preparing the hydrogel for scar film according to claim 1, wherein the method comprises the following steps: the hydrophilic or hydrophobic diisocyanate is obtained by reacting hydrophilic polyether polyol and second diisocyanate in a molar ratio of 1: 1-1: 3.
4. The method for preparing the hydrogel for scar film according to claim 1, wherein the method comprises the following steps: the molar ratio of the cross-linking agent to the first prepolymer is in a range of 0.2-0.4: 2, and the content of the crosslinking agent cannot be 0.
5. The method for preparing the hydrogel for scar film according to claim 1, wherein the method comprises the following steps: and C, mixing the hydrophobic or hydrophilic polyol and the hydrophilic or hydrophobic diisocyanate in the step A at the temperature of 80 ℃ for 90 min.
6. The method for preparing the hydrogel for scar film according to claim 1, wherein the method comprises the following steps: and B, mixing the first prepolymer and the cross-linking agent in the step B at the temperature of 80 ℃ for 90 min.
7. The method for preparing the hydrogel for scar film according to claim 2, wherein the method comprises the following steps: the branched polyol in step a1 was mixed with the first diisocyanate at a temperature of 80 ℃ for a reaction time of 90 min.
8. The method for preparing the hydrogel for scar film according to claim 2, wherein the method comprises the following steps: the temperature of mixing the triisocyanate intermediate and the hydrophobic or hydrophilic polyether polyol in the step a2 is 80 ℃, and the reaction time is 90 min.
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| CN109276746A (en) * | 2017-07-20 | 2019-01-29 | 泰陞国际科技股份有限公司 | Except scar patch and its manufacturing method |
| US20190160197A1 (en) * | 2016-04-08 | 2019-05-30 | Mölnlycke Health Care Ab | Composite materials in wound treatment |
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2021
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| US20160331860A1 (en) * | 2015-05-12 | 2016-11-17 | Taicend Technology Co., Ltd | Wet wound dressing |
| US20190160197A1 (en) * | 2016-04-08 | 2019-05-30 | Mölnlycke Health Care Ab | Composite materials in wound treatment |
| CN109276746A (en) * | 2017-07-20 | 2019-01-29 | 泰陞国际科技股份有限公司 | Except scar patch and its manufacturing method |
| US20210023256A1 (en) * | 2019-07-22 | 2021-01-28 | Tronjen Technology Inc. | Hydrogel wound dressing and method of preparing the same |
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