CN112798595A

CN112798595A - Sperm quality detector and detection system

Info

Publication number: CN112798595A
Application number: CN202011629339.XA
Authority: CN
Inventors: 岳春峰; 李鸿旺; 汝长海; 孙钰
Original assignee: Jiangsu Jicui Micro Nano Automation System And Equipment Technology Research Institute Co ltd
Current assignee: Suzhou Bozhi Medical Technology Co ltd
Priority date: 2020-12-30
Filing date: 2020-12-30
Publication date: 2021-05-14
Anticipated expiration: 2040-12-30
Also published as: CN112798595B

Abstract

The invention discloses a sperm quality detector and a sperm quality detection system, which comprise a machine body, a light source module and a micro-sampling module, wherein the light source module and the micro-sampling module are arranged on the machine body; the light source module is used for providing a light source; the microscopic sampling module comprises a lens component and a sampling component, wherein the sampling component is used for collecting a detection sample and amplifying the detection sample through the lens component. The invention provides a sperm quality detector and a sperm quality detection system, wherein the sperm quality detector is used for sampling and amplifying a detection sample, a camera of a mobile device can be used for recording a moving picture of sperm, the operation steps of a user are obviously reduced, the detection accuracy is improved, the sperm can clearly appear in a screen, the result is more visual, comprehensive and high in reliability, the user can carry out sperm quality detection at home, long queuing waiting in a hospital is not needed, a large amount of time is saved for the user, and the sperm quality detector is convenient, practical and easy to popularize.

Description

Sperm quality detector and detection system

Technical Field

The invention relates to the technical field of in-vitro health detection, in particular to a sperm quality detector and a sperm quality detection system.

Background

With the development of society, the health of men is also more and more emphasized. The data show that about 50% of the resulting infertility are male factors, 40% are female factors, and 10% are common or unknown factors. The items of sperm detection in hospitals mainly include multiple semen routine, seminal plasma biochemistry, sperm acrosome analysis, sperm infectivity index, antisperm antibody (AsAb) detection and sperm nucleus DNA fragment analysis seminal plasma trace element analysis, and the heavy detection content is obviously troublesome and laborious for doctors and patients.

The detection of the sperms is mostly performed by the artificial sampling and testing in hospitals, the detection items are various, the requirements on detection instruments, platforms and doctor experience are high, the detection time is long, the detection environment is only limited in laboratories or hospitals, the quality of the sperms of patients can be judged by combining the experience of the doctors, the sperm morphology system cannot judge the quality of the sperms, and the diagnosis report can be given by the observation of the doctors under the microscope.

In order to reduce the complexity of sperm detection, the sperm detection environment is limited. At present, the sperm can be detected by adopting household sperm detection test paper. Similar to a household pregnancy test paper, the test paper is convenient to use, and a user collects semen at home, transfers the semen to the test paper and waits for a measurement result. The basic principle of the test paper detection is to detect the concentration of the sperms, the colloidal gold method is used for detecting the concentration of sperm SP-10 protein (protein expressed on the sperms only), if the concentration of the SP-10 protein exceeds a set threshold value, the sperm concentration is normal, and a strip appears on the test paper to indicate that the sperms are normal. The detection test paper has the greatest advantage of low price, and the price of the mainstream detection test paper in the market is 50-100 yuan/time. However, the test paper has the prominent problems that the detection result is not intuitive and incomplete, and the reliability is poor. For example, the test paper can only detect the index of sperm concentration, the test paper cannot detect the activity, and a user can only see one strip and cannot see the activity state of the sperm.

Disclosure of Invention

In order to solve the above technical problems, an object of the present invention is to provide a sperm quality detecting apparatus, which comprises a body, and a light source module and a micro-sampling module arranged on the body;

the light source module is used for providing a light source;

the microscopic sampling module comprises a lens component and a sampling component, wherein the sampling component is used for collecting a detection sample and amplifying the detection sample through the lens component.

According to the technical scheme, the machine body comprises a bottom shell and an upper cover, the bottom shell is connected with the upper cover, and the upper cover is provided with the two-dimensional code for registering.

Technical scheme more than adopting, the organism includes first magnet, the upper cover passes through first magnet is connected the drain pan.

According to the technical scheme, the light source module comprises the USB interface and the LED lamp, and the USB interface and the LED lamp are arranged on the bottom shell.

Technical scheme more than adopting, the sampling subassembly includes sample handle, sample handle lid, sample portion and sample handle seat, sample portion locates sample handle covers, sample handle lid is located on the sample handle, the sample handle is connected sample handle seat, the sample handle seat is located in the organism.

According to the technical scheme, the sampling portion comprises a floating seat, a first sleeve cup and a second sleeve cup, the floating seat is arranged on the sampling handle cover, the first sleeve cup is detachably sleeved on the floating seat, the second sleeve cup is detachably sleeved on the first sleeve cup, and a detection sample is stored and detected between two end faces of the first sleeve cup and the second sleeve cup.

According to the technical scheme, the sampling portion comprises the elastic piece, the elastic piece is arranged on the sampling handle cover, and the elastic piece is connected with the floating seat.

Technical scheme more than adopting, the camera lens subassembly includes microscope lens, camera lens mounting nut and end cover, the microscope lens passes through camera lens mounting nut install in the sample handle seat, be equipped with the end cover on the sample handle seat, the end cover has the opening that exposes the microscope lens.

According to the technical scheme, the microscopic sampling module comprises a focusing assembly, the focusing assembly is sleeved on the microscope head and comprises a focusing device and a knob, the focusing device is connected with the knob, and a hole is formed in the middle of the focusing device.

Another object of the present invention is to provide a sperm detection system, which includes the above sperm quality detector and a mobile device, wherein the mobile device is placed on the surface of the sperm quality detector, and the camera of the mobile device faces the aperture of the focusing device included in the sperm quality detector.

Compared with the prior art, the sperm quality detector and the sperm quality detection system provided by the invention have the advantages that the sperm quality detector is utilized to sample and amplify a detection sample, a camera of a mobile device can be used for recording a moving picture of sperm, the operation steps of a user are obviously reduced, the detection accuracy is improved, the sperm can clearly appear in a screen, the result is more visual, comprehensive and high in reliability, the user can perform sperm quality detection at home, long queuing waiting in a hospital is not needed, a large amount of time is saved for the user, and the sperm quality detector and the sperm quality detection system are convenient, practical and easy to popularize.

Drawings

Fig. 1 is a schematic structural diagram of a first embodiment of the present invention.

Fig. 2 is a partially enlarged schematic view of a portion a in fig. 1.

Fig. 3 is an exploded view of the first embodiment of the present invention.

Fig. 4 is a schematic structural diagram of a focus adjustment assembly sleeved on a microscope head according to a first embodiment of the present invention.

Fig. 5 is a schematic structural diagram of a focus adjuster in the first embodiment of the present invention.

FIG. 6 is a schematic view of the structure of the lowest point stroke during the focusing process of the sperm quality monitor according to the first embodiment of the present invention.

FIG. 7 is a schematic view of the structure of the peak stroke during focusing of the sperm quality monitor according to the first embodiment of the present invention.

Fig. 8 is a schematic structural diagram of a second embodiment of the present invention.

The reference numbers in the figures illustrate: 1. a body; 11. a bottom case; 12. an upper cover; 13. a first magnet; 14. two-dimensional codes; 21. a USB interface; 22. an LED lamp; 3. a micro-sampling module; 31. a sampling handle; 32. a second magnet; 33. a sampling handle cover; 341. a floating seat; 342. a first set of cups; 343. a second set of cups; 344. an elastic member; 35. a sampling handle base; 36. a micro-lens; 37. an end cap; 38. a lens mounting nut; 39. a focusing assembly; 391. a focus adjuster; 392. a knob; 4. a mobile phone supporting plate; 5. a mobile device.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.

Examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are illustrative and intended to be illustrative of the invention and are not to be construed as limiting the invention.

In a first embodiment of the present invention, referring to fig. 1 to 7, the present invention provides a sperm quality detecting instrument, which includes a body 1, and a light source module and a micro-sampling module 3 disposed on the body 1.

The body 1 includes a bottom case 11 and an upper cover 12, and the bottom case 11 is connected to the upper cover 12. Preferably, the bottom case 11 and the upper cover 12 are magnetically connected. For example, the body 1 includes a first magnet 13, the first magnet 13 having opposite magnetic poles is disposed on the bottom case 11 and the upper case 12, and the bottom case 11 and the upper case 12 are connected by the first magnet 13. The body 1 can carry a mobile device 5 (e.g., a mobile phone) and house internal components.

The light source module comprises a USB interface 21 and an LED lamp 22, and provides a light source for microscopic detection, so that sperms are clear and the contrast is high.

The microscopic sampling module 3 comprises a lens component and a sampling component, wherein the sampling component is used for collecting a detection sample and amplifying the detection sample through the lens component. Specifically, the sampling assembly comprises a sampling handle 31, a sampling handle 31 cover, a sampling part and a sampling handle 31 seat, wherein the sampling part comprises a floating seat 341, a first sleeve cup 342, a second sleeve cup 343 and an elastic part 344; the lens assembly includes a microscope lens 36, a lens mounting nut 38 and an end cap 37. The second magnet 32 with opposite magnetic poles is arranged on the sampling handle 31 and the sampling handle 31 seat so as to enable the sampling handle 31 and the sampling handle 31 seat to be magnetically connected, the elastic piece 344 (preferably a spring) is sleeved on a cylinder inside the sampling handle 31 cover, the sampling handle 31 cover with a buckle is buckled with the sampling handle 31 together, the elastic piece 344 is connected with the floating seat 341, the floating seat 341 is used for installing the first sleeve cup 342, the first sleeve cup 342 is sleeved with the second sleeve cup 343, and a detection sample is stored between two end faces of the first sleeve cup 342 and the second sleeve cup 343. The floating seat 341 can float up and down with a certain travel distance under the action of the elastic member 344. The microscope lens 36 is first provided with a lens mounting nut 38 and then is press-fitted into a lens mounting hole of the sampling handle 31, the sampling handle 31 is fastened with the end cap 37, and the end cap 37 has an opening for exposing the microscope lens 36. The module is used for realizing the functions of sampling, microscopic observation and the like of a detection sample.

The microscope lens 36 has two types of fixed focusing and focusing, wherein when the lens is fixed and focusing is not performed, sperm display is blurred when the thickness model of the cover glass is changed, and the definition cannot be adjusted. In addition, although the lens can be focused, the device needs to be disassembled and focused, which not only damages the appearance of the device, but also cannot display the focusing in real time. Therefore, the microsampling module 3 of the present invention further comprises a focusing assembly 39, the focusing assembly 39 is sleeved on the microscope lens 36, the focusing assembly 39 comprises a focusing device 391 and a knob 392, the focusing device 391 is connected with the knob 392, and a hole is formed in the middle of the focusing device 391. Fig. 5 is a block diagram showing a focus adjuster 391 of the present invention. The four protrusions on the rear end face of the focusing device 391 are used for matching with the four grooves of the microscope lens 36 to rotate the microscope lens 36, and the middle hole is used for recording a microscopic sperm picture by a camera of a mobile phone.

As shown in fig. 6 and 7, in the focusing process, the sperm sample is stored between two end faces of the first set of cup 342 and the second set of cup 343, when the micro-lens 36 is at the lowest point relative to the lens mounting nut 38, the distance between the lens end face and the upper end face of the first set of cup 342 is 0.6mm, and when the micro-lens 36 is at the highest point relative to the lens mounting nut 38, the distance between the lens end face and the upper end face of the first set of cup 342 is 0.9mm, i.e. the focusing range is 0-0.3 mm.

The specific focusing operation process of the focusing device 391 of the present invention: when the sperm is not clearly displayed, the sperm quality detector is focused, the focusing assembly 39 is sleeved in the microscope lens 36, the knob 392 is rotated, the definition of the screen image changes, and the sperm is displayed to be clear when the knob 392 is finely adjusted, namely the focusing is finished. The focusing device 391 can focus the microscope lens 36 outside the device, and the problem that a user changes a focal plane in the use process after leaving a factory and adjusting the focus, so that a sperm quality detection report is inaccurate is solved. Meanwhile, the whole operation process has the characteristics of simple and direct operation, high focusing efficiency, convenient assembly and disassembly, real-time focusing and the like.

In a second embodiment of the invention, and with reference to FIG. 8, the invention provides a sperm cell detection system comprising a sperm quality detector as described above and a movement apparatus 5. Preferably, the mobile device 5 is a mobile phone, the surface of the sperm quality detector is provided with a mobile phone support plate 4, the mobile phone is placed on the surface of the sperm quality detector, the camera of the mobile phone is over against the hole of the focusing device 391 included in the sperm quality detector, and the mobile phone support plate 4 can prevent the problem of picture jitter caused by the relative movement of the camera of the mobile phone and the focusing device 391 when the mobile phone is in contact with each other in the focusing process.

The specific operation process of the invention is as follows: picking up the micro-sampling module 3 by two fingers, taking down the attracted sampling handle 31 seat, then taking down the first set of cup 342, dipping semen on the end face of the first set of cup 342, sleeving the second set of cup 343 on the first set of cup 342, then folding the sampling handle 31 and the sampling handle 31 seat, automatically attracting, positioning and matching the two components, sleeving the focusing component 39 into the microscope lens 36, then putting the micro-sampling module 3 into the machine body 1, supplying power to the sperm quality detector through the USB interface 21, turning on the LED lamp 22, turning on the mobile phone terminal analysis system APP, scanning the two-dimensional code 14 on the machine body 1 for registration and login, focusing the sperm quality detector when the sperm is not clearly displayed, rotating the knob 392, the screen image definition changes, displaying the sperm clarity when the knob 392 is finely adjusted, namely focusing is finished, displaying the sperm activity picture on the mobile phone, recording by clicking the screen, automatically analyzing the video after the recording is finished, and after the analysis is finished, giving a result report of indexes such as sperm motility, sperm concentration, sperm morphology and the like.

The invention provides a sperm quality detector and a sperm quality detection system, wherein the sperm quality detector is used for sampling and amplifying a detection sample, a camera of a mobile device 5 can be used for recording a moving picture of sperm, the operation steps of a user are obviously reduced, the detection accuracy is improved, the sperm can clearly appear in a screen, the result is more visual, comprehensive and high in reliability, the user can carry out sperm quality detection at home, long queuing waiting in a hospital is not needed, a large amount of time is saved for the user, and the sperm quality detector and the sperm quality detection system are convenient, practical and easy to popularize.

The above-mentioned embodiments are merely preferred embodiments for fully illustrating the present invention, and the scope of the present invention is not limited thereto. The equivalent substitution or change made by the technical personnel in the technical field on the basis of the invention is all within the protection scope of the invention. The protection scope of the invention is subject to the claims.

Claims

1. A sperm quality detector, which is characterized in that: the device comprises a machine body, a light source module and a micro-sampling module, wherein the light source module and the micro-sampling module are arranged on the machine body;

the light source module is used for providing a light source;

2. A sperm quality monitor as described in claim 1, wherein: the machine body comprises a bottom shell and an upper cover, the bottom shell is connected with the upper cover, and the upper cover is provided with a two-dimensional code for registration and login.

3. A sperm quality measuring instrument as described in claim 2, wherein: the machine body comprises a first magnet, and the upper cover is connected with the bottom shell through the first magnet.

4. A sperm quality monitor as described in claim 1, wherein: the light source module comprises a USB interface and an LED lamp, and the USB interface and the LED lamp are arranged on the bottom shell.

5. A sperm quality monitor as described in claim 1, wherein: the sampling assembly comprises a sampling handle, a sampling handle cover, a sampling part and a sampling handle seat, wherein the sampling part is arranged on the sampling handle cover, the sampling handle cover is arranged on the sampling handle, the sampling handle is connected with the sampling handle seat, and the sampling handle seat is arranged in the machine body.

6. A sperm quality monitor as described in claim 5, wherein: the sampling part comprises a floating seat, a first sleeve cup and a second sleeve cup, the floating seat is arranged on the sampling handle cover, the first sleeve cup is detachably sleeved on the floating seat, the second sleeve cup is detachably sleeved on the first sleeve cup, and a detection sample is stored between two end faces of the first sleeve cup and the second sleeve cup.

7. A sperm quality monitor as described in claim 6, wherein: the sampling part comprises an elastic piece, the sampling handle cover is provided with the elastic piece, and the elastic piece is connected with the floating seat.

8. A sperm quality monitor as described in claim 1, wherein: the lens component comprises a microscope lens, a lens mounting nut and an end cover, the microscope lens passes through the lens mounting nut and is mounted in the sampling handle seat, the end cover is arranged on the sampling handle seat, and the end cover is provided with an opening for exposing the microscope lens.

9. A sperm quality monitor as described in claim 1, wherein: the microscope sampling module comprises a focusing assembly, the focusing assembly is sleeved on the microscope head and comprises a focusing device and a knob, the focusing device is connected with the knob, and a hole is formed in the middle of the focusing device.

10. A sperm detection system, comprising: comprising a sperm quality detector according to any one of claims 1 to 9;

the sperm quality detector is characterized by further comprising a mobile device, wherein the mobile device is placed on the surface of the sperm quality detector, and a camera of the mobile device is over against a hole of a focusing device contained in the sperm quality detector.