CN112773772A - Water shield polysaccharide tablet and preparation method thereof - Google Patents
Water shield polysaccharide tablet and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a brasenia schreberi polysaccharide tablet and a preparation method thereof, belonging to the technical field of deep processing of brasenia schreberi, the brasenia schreberi polysaccharide tablet is composed of 100-6000 parts by weight of brasenia schreberi polysaccharide, 90-6000 parts by weight of calcium sulfate, 10-1000 parts by weight of microcrystalline cellulose, 10-1000 parts by weight of cross-linked sodium carboxymethyl cellulose and 1-100 parts by weight of magnesium stearate; the water shield polysaccharide, calcium sulfate, microcrystalline cellulose, croscarmellose sodium and magnesium stearate are subjected to dry powder premixing, wet granulation, fluidized bed drying, granule finishing, total mixing, tabletting, coating and other preparation processes to obtain the water shield polysaccharide tablet. The prepared brasenia schreberi polysaccharide tablet has the advantages of neat appearance, moisture resistance, easy storage, convenient carrying, more convenient eating mode, good oral compliance and easy operation, and can realize industrial production.
Description
Technical Field
The invention belongs to the technical field of water shield deep processing, and particularly relates to a water shield polysaccharide tablet and a preparation method thereof.
Background
Water shield (Brasenia schreberi J.F. Gmel.) also called as herba Solani Nigri, horse chestnut, herba Calthae Membranaceae, lake vegetable, etc. is perennial aquatic perennial root herb, is warm in nature, is suitable for growth in a clean water pond, floats on water surface or potential water, tender stem and leaf back have colloidal transparent substance, and tender stem and tender leaf are eaten. The water shield is widely distributed in a plurality of regions of northern hemisphere, and is mainly distributed in China, Japan, India, Australia, North America, Canada and other places, and the east of oceania and the west of Africa are distributed; the Chinese medicinal composition is mainly distributed in seven provinces of Yunnan, Sichuan, Hunan, Hubei, Jiangxi, Zhejiang and Jiangsu, and is widely distributed in regions which are 30 degrees below the north latitude. The water shield contains acidic polysaccharide, protein, amino acid, vitamin, histamine, trace elements and the like, and is rich in medical and edible dual-value. The water shield has the functions of clearing away heat and toxic materials, inducing diuresis and reducing edema, and is suitable for patients with hypertension, carbuncle, cellulitis, furuncle, erysipelas, acute icteric hepatitis and various cancers, in particular for patients with digestive system malignant tumors such as esophageal cancer and gastric cancer. The water shield is rich in colloid protein, carbohydrate, fat, various vitamins and mineral substances, and the water shield has the health-care function of medicine and food when being eaten frequently and is used as medicine by the whole herb.
The water shield polysaccharide is an acidic fruit polysaccharide, and consists of fucose, arabinose, xylose, mannose, galactose and glucuronic acid, the water shield contains abundant polysaccharide substances, the polysaccharide accounts for 50 percent of dry weight and has the highest proportion in various contained nutrient components, the polysaccharide is a better immune promoter and can promote macrophages to phagocytose foreign matters so as to inhibit the generation and development of tumors, the water shield polysaccharide is obtained by hot water leaching of cathayers such as the royal jelly and the like and is used for mouse immune experiments, the result shows that the weight of the spleen of a mouse is increased, the hemolysin generation is promoted along with the enhancement of the phagocytic function of the macrophages, the nucleic acid infiltration effect of 3H-TdR and 3H-uR on lymphocytes is realized, and the lymphocyte transformation is also promoted so as to increase the immune function of an organism, so that the water shield polysaccharide is a good immune promoter; medical research proves that: the macrophage function of most cancer patients is remarkably reduced, and the polysaccharide strengthens the immune system of the body and enhances the immunocompetence through host intermediary action so as to achieve the aim of treating the cancer. Secondly, the water shield polysaccharide has good effect on diabetes and hypertension, the water shield polysaccharide obtained by water extraction and alcohol precipitation by Liu Cuili and other people is used for the diabetes mouse experiment, and research results show that the water shield polysaccharide has good effect on reducing blood sugar and blood fat.
At present, the research on the water shield polysaccharide mostly focuses on the research on an extraction, purification and preparation method, a chemical structure and biological activity of the water shield polysaccharide, or the water shield polysaccharide is used as a component to be added into other preparations to play a role; for further improving the added value of the water shield polysaccharide, the water shield polysaccharide is developed into related medical health-care food but is rarely reported, and for the purpose, the water shield polysaccharide is necessary to be developed into a high added value preparation.
Disclosure of Invention
The invention provides a brasenia schreberi polysaccharide tablet and a preparation method thereof, fills the blank in the field of brasenia schreberi polysaccharide solid preparations in the prior art, improves the additional value of brasenia schreberi polysaccharide, has simple preparation method and easy operation, and can realize industrial production.
The invention provides a brasenia schreberi polysaccharide tablet which is composed of the following components in parts by weight: 100-6000 parts of water shield polysaccharide, 90-6000 parts of calcium sulfate, 10-1000 parts of microcrystalline cellulose, 10-1000 parts of croscarmellose sodium and 1-100 parts of magnesium stearate.
The invention also provides a preparation method of the brasenia schreberi polysaccharide tablet, which comprises the following steps:
step 1, weighing the following raw materials in parts by weight: 100-6000 parts of water shield polysaccharide, 90-6000 parts of calcium sulfate, 10-1000 parts of microcrystalline cellulose, 10-1000 parts of croscarmellose sodium and 1-100 parts of magnesium stearate;
step 2, granulation
Respectively sieving the water shield polysaccharide and the calcium sulfate, the microcrystalline cellulose and the croscarmellose sodium weighed in the step 1 with a 80-mesh sieve, mixing the water shield polysaccharide and the calcium sulfate, adding the mixture into a wet mixing granulator, sequentially adding the croscarmellose sodium and the microcrystalline cellulose for premixing, adding a binder solution, and uniformly stirring to obtain wet granules;
step 3, finishing
Drying the wet granules prepared in the step 2 in fluidized bed drying equipment until the moisture content of the wet granules is 2-5% to obtain dry granules, and passing the dry granules through a screen with the aperture of 0.8-2 mm in a crushing and sizing machine to obtain uniform granules;
step 4, total mixing
Adding the uniform particles obtained in the step (3) into a universal mixer, and simultaneously adding the magnesium stearate weighed in the step (1) for total mixing to obtain an intermediate;
step 5, tabletting
Tabletting the intermediate obtained in the step 4 by a tabletting machine to obtain brasenia schreberi polysaccharide tablets;
step 6, coating
And (5) performing film coating on the brasenia schreberi polysaccharide tablets in the step 5 in a coating machine, spraying a coating solution to the surfaces of the brasenia schreberi polysaccharide tablets by using a peristaltic pump and a spray gun, and increasing the weight by 2.8-3.2% to obtain the brasenia schreberi polysaccharide tablets.
Preferably, the preparation method of the water shield polysaccharide comprises the following steps: drying fresh water shield, and crushing to 60-100 meshes to obtain water shield powder; adding 20-40 times of 0.2-0.4 mol/L NaOH or KOH aqueous solution, and stirring and extracting at 55-75 ℃ for 1-3 h; adjusting the pH value to 6-8, adding papain in an amount which is 1-3% of the weight of the water shield powder, performing enzymolysis for 4-6 hours at 50-70 ℃, and heating to 85-95 ℃ for 10-20 min; filtering to obtain filtrate, decolorizing the filtrate by adopting a polyamide chromatographic column, eluting with pure water and collecting eluent; carrying out ultrafiltration concentration on the eluent until the volume of the eluent is 1/3-1/2, and intercepting macromolecular polysaccharide with the molecular weight of more than 5000Da to obtain a concentrated solution; adding absolute ethyl alcohol into the concentrated solution until the concentration of the ethyl alcohol is 50% -90%, and performing precipitation and centrifugation to obtain polysaccharide precipitate; and adding deionized water with the volume of 5-10 times of that of the polysaccharide precipitate for redissolution, and performing spray drying to obtain the water shield polysaccharide, wherein the content of the water shield polysaccharide is 70-80%.
Preferably, in the step 2, the adhesive is an ethanol solution with the mass fraction of 30-70%.
Preferably, in the step 2, the stirring speed is 200-250 rpm and the cutting speed of the cutter is 600-800 rpm when the wet mixing granulator is premixed; the stirring speed is 250 to 300rpm and the cutting speed of the cutter is 1000 to 1200rpm when preparing wet granules.
Preferably, in step 3, the drying parameters of the fluidized bed drying equipment are as follows: the air inlet temperature is 60-80 ℃, the material temperature is 50-70 ℃, and the rotating speed of a fan is 1500-2000 rpm.
Preferably, in step 4, the total mixing control parameters in the universal mixer are as follows: the rotation speed of the main shaft is 12-18 rpm, the rotation speed of the auxiliary shaft is 4-6 rpm, and the mixing time is 1000-1500 s.
Preferably, in step 5, the tabletting parameters are as follows: the weight of the tablet is 210-282 mg, the stamping die of the tablet press is a shallow arc concave stamping die with the thickness of 9mm, and the pressure is 50-70N.
Preferably, in the step 6, the coating solution is prepared from an Opadry film coating material and 30-70% of ethanol solution, and the weight ratio of the Opadry film coating material to the ethanol solution is 1: 8-12; the rotating speed of the peristaltic pump is 4rpm, the rotating speed of a coating machine host is 3-5 rpm, the rotating speed of a fan is 800-1200 rpm, the air inlet temperature is 50-70 ℃, the material temperature is 36-42 ℃, and the atomizing pressure of the spray gun is 0.1-0.2 Mpa.
Compared with the prior art, the invention has the beneficial effects that:
(1) the invention provides a brasenia schreberi polysaccharide tablet, which fills the blank in the field of brasenia schreberi polysaccharide solid preparations in the prior art and improves the additional value of brasenia schreberi polysaccharide.
(2) The prepared brasenia schreberi polysaccharide tablet has the advantages of neat appearance, moisture resistance, easy storage, convenient carrying, more convenient eating mode and good oral compliance.
(3) The preparation method of the brasenia schreberi polysaccharide tablet is realized through preparation pilot plant on the basis of prescription research, parameter research and control are carried out by completely simulating production equipment, and the method is simple, easy to operate and suitable for industrial production.
Detailed Description
In order to make the technical solutions of the present invention better understood and enable those skilled in the art to practice the present invention, the following embodiments are further described, but the present invention is not limited to the following embodiments.
The following test methods and detection methods, unless otherwise specified, are conventional methods; the reagents and starting materials are all commercially available, unless otherwise specified.
Example 1
A brasenia schreberi polysaccharide tablet is prepared from the following raw materials by weight: 100g of water shield polysaccharide, 90g of calcium sulfate, 10g of microcrystalline cellulose, 10g of croscarmellose sodium and 1g of magnesium stearate.
Step 1: the water shield polysaccharide is prepared by the following preparation method, wherein fresh water shield is dried and then crushed to 60 meshes to obtain water shield powder; adding 20 times of 0.2mol/L NaOH aqueous solution, and stirring and extracting for 1h at 55 ℃; adjusting pH to 6, adding papain in an amount of 1% of the weight of the water shield powder, performing enzymolysis at 50 deg.C for 4h, heating to 85 deg.C, and maintaining for 10 min; filtering to obtain filtrate, decolorizing the filtrate by adopting a polyamide chromatographic column, eluting with pure water and collecting eluent; performing ultrafiltration concentration on the eluent until the volume of the eluent is 1/3, and intercepting macromolecular polysaccharide with the molecular weight of more than 5000Da to obtain concentrated solution; adding absolute ethyl alcohol into the concentrated solution until the concentration of the ethyl alcohol is 50%, precipitating and centrifuging to obtain polysaccharide precipitate; adding deionized water with the volume 5 times that of the polysaccharide precipitate for redissolution, and performing spray drying to obtain water shield polysaccharide;
step 2: weighing the water shield polysaccharide, the calcium sulfate, the microcrystalline cellulose and the croscarmellose sodium, respectively sieving with a 80-mesh sieve, firstly mixing the water shield polysaccharide and the calcium sulfate, adding into a wet mixing granulator, then sequentially adding the croscarmellose sodium and the microcrystalline cellulose, controlling the stirring speed to be 200rpm, pre-mixing for 15min at the cutter cutting speed of 600rpm, adding 10% by weight of 30% ethanol solution for 90s, controlling the stirring speed to be 250rpm, and stirring for 4min at the cutter cutting speed of 1000rpm to obtain 1000 wet granules.
And step 3: and (3) drying the wet granules prepared in the step (2) in fluidized bed drying equipment for 5min, controlling the air inlet temperature to be 60 ℃, the material temperature to be 50 ℃ and the rotating speed of a fan to be 1500rpm, obtaining dry granules when the moisture content of the wet granules is 5%, and obtaining uniform granules after the dry granules pass through a screen with the aperture of 0.8mm in a crushing and sizing machine.
And 4, step 4: and (3) adding the uniform granules obtained in the step (3) into a universal mixer, simultaneously adding 1g of magnesium stearate for total mixing, and controlling the rotation speed of a main shaft to be 12rpm and the rotation speed of an auxiliary shaft to be 4rpm, wherein the mixing time is 1000s, so as to obtain an intermediate.
And 5: and (4) putting the intermediate in the step (4) into a feed hopper of a tablet press, controlling the tablet weight to be 211mg, punching a die of the tablet press to be a shallow arc concave punch with the diameter of 9mm, and pressing to obtain the brasenia schreberi polysaccharide tablet under the pressure of 50N.
Step 6: performing film coating on the brasenia schreberi polysaccharide tablets in the step 5 in a coating machine, and spraying coating liquid to the surface of the brasenia schreberi polysaccharide tablets by using a peristaltic pump and a spray gun, wherein the coating liquid is prepared by an Opadry film coating material and a 30% ethanol solution, and the weight ratio of the Opadry film coating material to the ethanol solution is 1: 8; the rotation speed of the peristaltic pump is 4rpm, the rotation speed of a coating machine host is 3rpm, the rotation speed of a fan is 800rpm, the air inlet temperature is 50 ℃, the material temperature is 36 ℃, the spray gun atomization pressure is 0.1Mpa, and the weight is increased by 2.8 percent to obtain the brasenia schreberi polysaccharide tablet.
Example 2
A brasenia schreberi polysaccharide tablet is prepared from the following raw materials by weight: 6000g of water shield polysaccharide, 6000g of calcium sulfate, 1000g of microcrystalline cellulose, 1000g of cross-linked carboxymethyl cellulose and 100g of magnesium stearate.
Step 1: the water shield polysaccharide is prepared by the following method, fresh water shield is dried and then crushed to 100 meshes to obtain water shield powder; adding 40 times of 0.4mol/L KOH aqueous solution, and stirring and extracting for 3 hours at 75 ℃; adjusting pH to 8, adding papain in an amount of 3% of the weight of the water shield powder, performing enzymolysis at 70 deg.C for 6h, and heating to 95 deg.C for 20 min; filtering to obtain filtrate, decolorizing the filtrate by adopting a polyamide chromatographic column, eluting with pure water and collecting eluent; performing ultrafiltration concentration on the eluent until the volume of the eluent is 1/2, and intercepting macromolecular polysaccharide with the molecular weight of more than 5000Da to obtain concentrated solution; adding absolute ethyl alcohol into the concentrated solution until the concentration of the ethyl alcohol is 90%, and precipitating and centrifuging to obtain polysaccharide precipitate; adding deionized water with the volume of 10 times of that of the polysaccharide precipitate for redissolution, and performing spray drying to obtain water shield polysaccharide;
step 2: weighing the water shield polysaccharide, the calcium sulfate, the microcrystalline cellulose and the croscarmellose sodium, respectively sieving with a 80-mesh sieve, firstly mixing the water shield polysaccharide and the calcium sulfate, adding into a wet mixing granulator, then sequentially adding the croscarmellose sodium and the microcrystalline cellulose, controlling the stirring speed to be 250rpm, pre-mixing the mixture at the cutter cutting speed of 800rpm for 20min, adding 15% by weight of 70% ethanol solution in 90s, controlling the stirring speed to be 30rpm, and stirring the mixture at the cutter cutting speed of 1200rpm for 6min to obtain 50000 wet granules.
And step 3: and (3) drying the wet granules prepared in the step (2) in fluidized bed drying equipment for 8min, controlling the air inlet temperature to be 80 ℃, the material temperature to be 70 ℃ and the rotating speed of a fan to be 2000rpm, obtaining dry granules when the moisture content of the wet granules is 2%, and obtaining uniform granules after the dry granules pass through a screen with the aperture of 2mm in a crushing and sizing machine.
And 4, step 4: and (3) adding the uniform granules obtained in the step (3) into a universal mixer, simultaneously adding 100g of magnesium stearate for total mixing, and controlling the rotation speed of a main shaft to be 18rpm and the rotation speed of an auxiliary shaft to be 6rpm, wherein the mixing time is 1500s to obtain an intermediate.
And 5: and (4) putting the intermediate in the step 4 into a feed hopper of a tablet press, controlling the tablet weight to be 282mg, and pressing the tablet press into a shallow arc concave punch with the die diameter of 9mm under the pressure of 70N to obtain the brasenia schreberi polysaccharide tablet.
Step 6: performing film coating on the brasenia schreberi polysaccharide tablets in the step 5 in a coating machine, and spraying coating liquid to the surface of the brasenia schreberi polysaccharide tablets by using a peristaltic pump and a spray gun, wherein the coating liquid is prepared by an Opadry film coating material and a 70% ethanol solution, and the weight ratio of the Opadry film coating material to the ethanol solution is 1: 12; the rotation speed of the peristaltic pump is 4rpm, the rotation speed of a coating machine host is 5rpm, the rotation speed of a fan is 1200rpm, the air inlet temperature is 70 ℃, the material temperature is 42 ℃, the spray gun atomization pressure is 0.2Mpa, and the weight is increased by 3.2 percent to obtain the brasenia schreberi polysaccharide tablet.
Example 3
A brasenia schreberi polysaccharide tablet is prepared from the following raw materials by weight: 1100g of water shield polysaccharide, 1100g of calcium sulfate, 150g of microcrystalline cellulose, 150g of croscarmellose sodium and 15g of magnesium stearate.
Step 1: the water shield polysaccharide is prepared by the following preparation method, wherein fresh water shield is dried and then crushed to 100 meshes to obtain water shield powder; adding 40 times of 0.3mol/L NaOH aqueous solution, and stirring and extracting for 2 hours at 65 ℃; adjusting pH to 7, adding papain in an amount of 2.5% of the weight of the water shield powder, performing enzymolysis at 60 deg.C for 5h, heating to 90 deg.C, and maintaining for 15 min; filtering to obtain filtrate, decolorizing the filtrate by adopting a polyamide chromatographic column, eluting with pure water and collecting eluent; performing ultrafiltration concentration on the eluent until the volume of the eluent is 1/2, and intercepting macromolecular polysaccharide with the molecular weight of more than 5000Da to obtain concentrated solution; adding absolute ethyl alcohol into the concentrated solution until the concentration of the ethyl alcohol is 70%, and precipitating and centrifuging to obtain polysaccharide precipitate; and adding deionized water with the volume of 8 times of that of the polysaccharide precipitate for redissolution, and performing spray drying to obtain the water shield polysaccharide.
Step 2: weighing the water shield polysaccharide, the calcium sulfate, the microcrystalline cellulose and the croscarmellose sodium, respectively sieving with a 80-mesh sieve, mixing the water shield polysaccharide and the calcium sulfate, adding into a wet mixing granulator, sequentially adding the croscarmellose sodium and the microcrystalline cellulose, controlling the stirring speed to be 230rpm, the cutter cutting speed to be 700rpm, premixing for 18min, adding 70% ethanol solution with the weight of 12% in 100s, controlling the stirring speed to be 280rpm, and stirring for 6min with the cutter cutting speed to be 1100rpm, thereby obtaining 10000 wet granules.
And step 3: and (3) drying the wet granules prepared in the step (2) in fluidized bed drying equipment for 8min, controlling the air inlet temperature to be 70 ℃, the material temperature to be 55 ℃ and the rotating speed of a fan to be 1800rpm, obtaining dry granules when the moisture content of the wet granules is 4%, and passing the dry granules through a screen with the aperture of 1mm in a crushing and granulating machine to obtain uniform granules.
And 4, step 4: and (3) adding the uniform granules obtained in the step (3) into a universal mixer, simultaneously adding 15g of magnesium stearate for total mixing, and controlling the rotation speed of a main shaft to be 18rpm and the rotation speed of an auxiliary shaft to be 6rpm, wherein the mixing time is 1500s, so as to obtain an intermediate.
And 5: and (4) putting the intermediate in the step (4) into a feed hopper of a tablet press, controlling the tablet weight to be 251mg, punching a die of the tablet press into a shallow arc concave punch with the diameter of 9mm, and tabletting under the pressure of 60N to obtain the brasenia schreberi polysaccharide tablets.
Step 6: performing film coating on the brasenia schreberi polysaccharide tablets in the step 5 in a coating machine, and spraying coating liquid to the surface of the brasenia schreberi polysaccharide tablets by using a peristaltic pump and a spray gun, wherein the coating liquid is prepared by an Opadry film coating material and a 50% ethanol solution, and the weight ratio of the Opadry film coating material to the ethanol solution is 1: 10; the rotation speed of the peristaltic pump is 4rpm, the rotation speed of a coating machine host is 4rpm, the rotation speed of a fan is 1000rpm, the air inlet temperature is 63 ℃, the material temperature is 40 ℃, the spray gun atomization pressure is 0.15Mpa, and the weight is increased by 3% to obtain the brasenia schreberi polysaccharide tablet.
The brasenia schreberi polysaccharide tablets prepared in the above examples 1 to 3 were tested according to the relevant standard of "chinese pharmacopoeia", and the results are shown in table 1:
TABLE 1 physicochemical indexes of Brasenia schreberi polysaccharide tablet
1. And (3) measuring the content of the water shield polysaccharide extract: the content of the water shield polysaccharide extracts in examples 1, 2 and 3 was measured by referring to the method for measuring the content of ganoderan in 2020 edition of the Chinese pharmacopoeia, namely the anthrone sulfate method, and the results were 78.5%, 78.1% and 79.2%, respectively.
2. And (3) measuring the hardness of the water shield polysaccharide tablet: 10 pieces of each of the brasenia schreberi polysaccharide tablets prepared in example 1, example 2 and example 3 were randomly selected, and the hardness of the samples was measured using a hardness tester, and the results were averaged to obtain 55.83N, 60.12N and 58.76N, respectively.
3. And (3) determining the weight difference: referring to appendix I (weight difference) of 2020 edition of China pharmacopoeia, the examination method comprises the following steps: respectively selecting 20 pieces of the brasenia schreberi polysaccharide tablets prepared in the example 1, the example 2 and the example 3 randomly, precisely weighing the total weight respectively, obtaining the average weight of each tablet, precisely weighing each tablet, wherein the weight difference limit of each tablet is +/-7.5% compared with the average weight of each tablet, and the brasenia schreberi polysaccharide tablets prepared in the example 1, the example 2 and the example 3 do not exceed the weight difference limit and all meet the requirements.
4. Determination of disintegration time limit: 6 pieces of the brasenia schreberi polysaccharide tablets prepared in example 1, example 2 and example 3 are randomly selected respectively according to an appendix XA (disintegration time limit inspection method) of 2020 edition of China pharmacopoeia, the disintegration time limits are 11.3min, 11.8min and 10.9min respectively, and the tablets are completely disintegrated within 30 minutes and all meet the requirements.
In conclusion, the prepared brasenia schreberi polysaccharide tablet has the advantages of neat appearance, moisture resistance, easy storage, convenient carrying, more convenient eating way and good oral compliance; fills the blank in the field of the water shield polysaccharide solid preparation in the prior art, and improves the additional value of the water shield polysaccharide; the preparation method of the brasenia schreberi polysaccharide tablet is realized through preparation pilot plant on the basis of prescription research, parameter research and control are carried out by completely simulating production equipment, and the method is simple, easy to operate and suitable for industrial production.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.
Claims (9)
1. The brasenia schreberi polysaccharide tablet is characterized by comprising the following components in parts by weight: 100-6000 parts of water shield polysaccharide, 90-6000 parts of calcium sulfate, 10-1000 parts of microcrystalline cellulose, 10-1000 parts of croscarmellose sodium and 1-100 parts of magnesium stearate.
2. The method for preparing the brasenia schreberi polysaccharide tablet of claim 1, which comprises the following steps:
step 1, weighing the following raw materials in parts by weight: 100-6000 parts of water shield polysaccharide, 90-6000 parts of calcium sulfate, 10-1000 parts of microcrystalline cellulose, 10-1000 parts of croscarmellose sodium and 1-100 parts of magnesium stearate;
step 2, granulation
Respectively sieving the water shield polysaccharide and the calcium sulfate, the microcrystalline cellulose and the croscarmellose sodium weighed in the step 1 with a 80-mesh sieve, mixing the water shield polysaccharide and the calcium sulfate, adding the mixture into a wet mixing granulator, sequentially adding the croscarmellose sodium and the microcrystalline cellulose for premixing, adding a binder solution, and uniformly stirring to obtain wet granules;
step 3, finishing
Drying the wet granules prepared in the step 2 in fluidized bed drying equipment until the moisture content of the wet granules is 2-5% to obtain dry granules, and passing the dry granules through a screen with the aperture of 0.8-2 mm in a crushing and sizing machine to obtain uniform granules;
step 4, total mixing
Adding the uniform particles obtained in the step (3) into a universal mixer, and simultaneously adding the magnesium stearate weighed in the step (1) for total mixing to obtain an intermediate;
step 5, tabletting
Tabletting the intermediate obtained in the step 4 by a tabletting machine to obtain brasenia schreberi polysaccharide tablets;
step 6, coating
And (5) performing film coating on the brasenia schreberi polysaccharide tablets in the step 5 in a coating machine, spraying a coating solution to the surfaces of the brasenia schreberi polysaccharide tablets by using a peristaltic pump and a spray gun, and increasing the weight by 2.8-3.2% to obtain the brasenia schreberi polysaccharide tablets.
3. The method for preparing the brasenia schreberi polysaccharide tablet of claim 2, wherein the method for preparing the brasenia schreberi polysaccharide comprises the following steps: drying and crushing fresh water shield to obtain water shield powder, extracting with an alkali solution, adding papain for enzymolysis, filtering to obtain a filtrate, decolorizing the filtrate, eluting to obtain an eluent, ultrafiltering and concentrating the eluent to obtain a concentrated solution, centrifuging the concentrated solution by using absolute ethyl alcohol to obtain a polysaccharide precipitate, redissolving with water, and spray-drying to obtain the water shield polysaccharide.
4. The method for preparing brasenia schreberi polysaccharide tablet of claim 2, wherein in step 2, the binder is ethanol solution with 30-70% mass fraction.
5. The method for preparing the brasenia schreberi polysaccharide tablet of claim 2, wherein in step 2, the stirring speed of the wet mixing granulator is 200-250 rpm during premixing, and the cutting speed of the cutter is 600-800 rpm; the stirring speed is 250 to 300rpm and the cutting speed of the cutter is 1000 to 1200rpm when preparing wet granules.
6. The method for preparing brasenia schreberi polysaccharide tablet of claim 2, wherein in step 3, the drying parameters of the fluidized bed drying device are: the air inlet temperature is 60-80 ℃, the material temperature is 50-70 ℃, and the rotating speed of a fan is 1500-2000 rpm.
7. The method for preparing brasenia schreberi polysaccharide tablet of claim 2, wherein in step 4, the total mixing control parameters in the universal mixer are: the rotation speed of the main shaft is 12-18 rpm, the rotation speed of the auxiliary shaft is 4-6 rpm, and the mixing time is 1000-1500 s.
8. The method for preparing brasenia schreberi polysaccharide tablet of claim 2, wherein in step 5, the tabletting parameters are as follows: the weight of the tablet is 210-282 mg, the stamping die of the tablet press is a shallow arc concave stamping die with the thickness of 9mm, and the pressure is 50-70N.
9. The method for preparing the brasenia schreberi polysaccharide tablet of claim 2, wherein in step 6, the coating solution is prepared from an opadry film coating material and 30-70% ethanol solution, and the weight ratio of the opadry film coating material to the ethanol solution is 1: 8-12; the rotating speed of the peristaltic pump is 4rpm, the rotating speed of a coating machine host is 3-5 rpm, the rotating speed of a fan is 800-1200 rpm, the air inlet temperature is 50-70 ℃, the material temperature is 36-42 ℃, and the atomizing pressure of the spray gun is 0.1-0.2 Mpa.
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