CN112773477A - Tissue puncture indicating system based on lateral scanning OCT endoscopic probe and operation method - Google Patents
Tissue puncture indicating system based on lateral scanning OCT endoscopic probe and operation method Download PDFInfo
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- A61B17/34—Trocars; Puncturing needles
- A61B17/3403—Needle locating or guiding means
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/37—Surgical systems with images on a monitor during operation
- A61B2090/373—Surgical systems with images on a monitor during operation using light, e.g. by using optical scanners
- A61B2090/3735—Optical coherence tomography [OCT]
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Abstract
The invention relates to a tissue puncture indicating system based on a side scanning OCT endoscopic probe and an operation method, wherein the system comprises: the pipe collector comprises a first pipeline communicated to the second side from the first side of the pipe collector, a second pipeline communicated with the first pipeline, and a third opening formed on the outer surface of the pipe collector by the second pipeline and used as an injection liquid charging port; the tail end of the needle stem is connected with a second opening, and the inner cavity of the needle stem is communicated with the first pipeline through the second opening; the rotating sleeve ring is sleeved on the rotating connecting part so as to be rotatably connected with the header device, and the rotating shaft is parallel to the needle stem main shaft of the puncture injection needle connected with the second opening; the lateral scanning OCT endoscopic probe is fixedly connected with the rotating collar. Compared with the puncture indication based on the electrical impedance value and the mechanical resistance value at the top end of the vein puncture needle, the puncture indication is more reliable and is not easily interfered by factors of non-puncture positions.
Description
Technical Field
The invention relates to the field of medicine, in particular to a tissue puncture indicating system based on a lateral scanning OCT endoscopic probe, and further relates to an operation method of the tissue puncture indicating system based on the lateral scanning OCT endoscopic probe.
Background
OCT (optical coherence tomography) is a technique for non-invasive three-dimensional scanning imaging of the surface and internal structure of a sample using low-coherence light (usually near-infrared light). The spatial resolution of OCT images is typically on the order of microns, while the imaging depth for opaque samples is typically on the order of millimeters.
The venipuncture navigation is to realize the instant judgment of the position of the injection needle by carrying out instant imaging on the puncture needle and the tissues around the puncture needle in the venipuncture process. The venipuncture instruction is to immediately indicate whether the venipuncture needle has been inserted into a target blood vessel during venipuncture.
Exemplary venipuncture indication techniques include medical image-based puncture navigation and puncture indication based on puncture needle tip sensing. The puncture navigation based on the medical image displays the position of the target blood vessel by utilizing an ultrasonic or near infrared imaging technology, thereby finishing the instant determination of the position of the puncture needle relative to the target blood vessel and realizing the puncture navigation. However, the current medical imaging technology adopted in clinical practice can only realize the real-time imaging for the two-dimensional plane at each moment, so that the three-dimensional spatial position of the puncture needle cannot be precisely and immediately navigated, which easily causes the puncture operator to mistakenly determine the puncture needle actually located outside the imaging plane as being located within the imaging plane, thereby causing navigation errors and also failing to obtain accurate puncture indication. The current puncture indicating technology based on the puncture needle tip sensing comprises the step of judging whether the puncture needle has punctured into a target blood vessel or not according to an electrical impedance value or a mechanical resistance value of the environment where the puncture needle tip is located. However, the information on the electrical impedance detected at the tip of the needle is not sufficient to resolve multiple tissue types in the environment of the needle tip. The mechanical resistance value detected at the tip of the puncture needle is also influenced by various factors unrelated to the puncture position, such as the state of the punctured tissue, the angle of the puncture needle, the moving speed of the puncture needle and the like. Therefore, reliable puncture indication cannot be realized only by means of electrical impedance or mechanical resistance sensing of the puncture needle tip.
Disclosure of Invention
Based on this, it is necessary to provide a tissue puncture indication system based on a side-scanning OCT endoscopic probe.
A tissue puncture indicating system based on a side scanning OCT endoscopic probe comprises: a header having a hollow interior comprising a first conduit communicating from a first side to a second side of the header, the first conduit forming a first opening at the first side and a second opening at the second side, the hollow interior further comprising a second conduit communicating with the first conduit, the second conduit forming a third opening at an exterior surface of the header, the third opening acting as an injection port, the header further comprising a swivel connection disposed at the location of the first opening; the second opening of the puncture injection needle is used for connecting the tail end of the needle stem of the puncture injection needle, and the inner cavity of the needle stem of the puncture injection needle is communicated with the first pipeline through the second opening; the rotating sleeve ring is sleeved on the rotating connecting part and comprises a rotor, and a rotating shaft of the rotor is parallel to a needle stem main shaft of the puncture injection needle connected with the second opening; the side scanning OCT endoscopic probe is fixedly connected with the rotor so as to rotate along with the rotor; when the rotating sleeve ring is sleeved on the rotating connecting part, the tail end of the probe of the lateral scanning OCT endoscopic probe is exposed out of one end, away from the collector, of the rotating sleeve ring, the lateral scanning OCT endoscopic probe extends into the needle stem internal cavity of the puncture injection needle from the interior of the first pipeline, and the scanning window at the top end of the probe extends out of the top end of the puncture injection needle.
In one embodiment, the device further comprises a screw cap, and the screw cap is used for covering the rotary connecting part when the pipe collector is separated from the rotary sleeve ring and the side scanning OCT endoscopic probe so as to seal the first opening.
In one embodiment, the third port is for connecting an infusion tube.
In one embodiment, the hollow lumen is filled with a medical fluid and/or saline to exclude air from the hollow lumen when performing tissue penetration.
In one embodiment, the header includes a main body portion having the hollow inner chamber, and the rotation connection portion having a cylindrical shape, which is hollow as one end of the first pipe, the main body portion having a rectangular parallelepiped shape.
In one embodiment, the rotating collar is provided with a first cylindrical cavity with an inner diameter matched with the outer diameter of the rotating connecting part at a first end, and is further provided with a second cylindrical cavity communicated to the first cylindrical cavity at a second end, wherein the inner diameter of the second cylindrical cavity is matched with the outer diameter of the side scanning OCT endoscopic probe, and the side scanning OCT endoscopic probe is fixed in the second cylindrical cavity.
In one embodiment, the third opening is formed on the first side, and the second side is opposite to the first side.
In one embodiment, the side-scanning OCT endoscopic probe includes: the endoscopic probe needle stem is made based on a 30gauge (30G) hypodermic needle stem, and a scanning window is arranged on the side surface close to the needle tip; the optical fiber probe extends into and is fixed in the endoscopic probe needle stem and comprises a single mode optical fiber, a first coreless optical fiber, a GRIN optical fiber and a second coreless optical fiber which are sequentially connected, wherein the top end of the second coreless optical fiber is provided with a polishing surface with a 45-degree inclination angle, the optical fiber probe also comprises a metal coating arranged on the polishing surface, and the position of the metal coating corresponds to the position of the scanning window so that incident light reflected by the metal coating is emitted from the scanning window.
In one embodiment, the OCT imaging system further comprises: a light source for providing broadband near-infrared incident light; the optical fiber coupler is connected with the light source, the reference arm and the sample arm through optical fibers; one end of an optical fiber of the sample arm is connected with the optical fiber coupler, and the other end of the optical fiber of the sample arm is connected with the optical fiber exposed out of the tail end of the probe; the optical fiber end of the reference arm is connected with the optical fiber coupler; the reflecting unit is arranged at the other end of the optical fiber of the reference arm and used for reflecting the light emitted from the other end of the optical fiber of the reference arm back to the other end of the optical fiber of the reference arm; the spectrometer is connected with the optical fiber coupler through an optical fiber; the computer comprises frequency domain signal analysis software and is used for restoring the frequency domain interference optical signal into a time domain interference optical signal and then generating an OCT image; the optical fiber coupler is used for evenly distributing broadband near-infrared incident light provided by the light source to the reference arm and the sample arm, and is also used for enabling reflected light returned by the sample arm and reflected light returned by the reference arm to meet and interfere in the optical fiber coupler, enabling interference signals generated by interference to enter the spectrometer through optical fibers, and the spectrometer is used for obtaining frequency domain interference signals according to the interference signals and transmitting the frequency domain interference signals to the computer.
In one embodiment, the system is a venipuncture indicating system based on a side-scanning OCT endoscopic probe, and is used for indicating the position of a needle head of a puncture injection needle (whether the needle head is punctured into a vein) during venipuncture.
It is also necessary to provide a method for operating a tissue puncture indication system based on a side-scanning OCT endoscopic probe.
A method for operating a tissue puncture indication system based on a side scanning OCT endoscopic probe comprises the following steps: inserting a side-scanning OCT endoscopic probe connected with an OCT imaging system into a hollow inner cavity of a tube collector and a needle stem of a puncture injection needle, and ensuring that a scanning window at the top end of the side-scanning OCT endoscopic probe is extended out from the top end of the puncture injection needle; the hollow inner cavity of the header comprises a first pipeline communicated from a first side to a second side of the header, the first pipeline forms a first opening on the first side and a second opening on the second side, the second opening is connected with the tail end of the needle stem of the puncture injection needle, and the inner cavity of the needle stem of the puncture injection needle is communicated with the first pipeline through the second opening; the hollow inner cavity further comprises a second pipeline communicated with the first pipeline, the second pipeline forms a third opening on the outer surface of the pipe collector, and the third opening is connected with an infusion device; the header further comprises a swivel connection disposed at the first open location; sleeving a rotating sleeve ring on the rotating connecting part, wherein the rotating sleeve ring comprises a rotor, the lateral scanning OCT endoscopic probe is fixedly connected with the rotor, and a rotating shaft of the rotor is parallel to a needle stem main shaft of the puncture injection needle; the OCT imaging system works, the lateral scanning OCT endoscopic probe is driven to rotate by the rotating lantern ring to perform lateral scanning, and an instant scanning result is obtained by the OCT imaging system; if the needle head of the puncture injection needle reaches the target position, pulling out the side-scanning OCT endoscopic probe and the rotating collar from the tube collector; and covering a rotary cover on the rotary connecting part so as to seal the first opening.
In one embodiment, the method further comprises the step of filling the hollow inner cavity with a liquid medicine and/or physiological saline to remove air from the hollow inner cavity before performing the tissue puncture.
In one embodiment, the header includes a main body portion having the hollow inner chamber, and the rotation connection portion having a cylindrical shape, which is hollow as one end of the first pipe, the main body portion having a rectangular parallelepiped shape.
In one embodiment, the rotating collar is provided with a first cylindrical cavity with an inner diameter matched with the outer diameter of the rotating connecting part at a first end, and is further provided with a second cylindrical cavity communicated to the first cylindrical cavity at a second end, wherein the inner diameter of the second cylindrical cavity is matched with the outer diameter of the side scanning OCT endoscopic probe, and the side scanning OCT endoscopic probe is fixed in the second cylindrical cavity.
In one embodiment, the third opening is formed on the first side, and the second side is opposite to the first side.
In one embodiment, the side-scanning OCT endoscopic probe includes: the endoscopic probe needle stem is made based on a 30G hypodermic needle stem, and a scanning window is arranged on the side surface close to the needle tip; the optical fiber probe extends into and is fixed in the endoscopic probe needle stem and comprises a single mode optical fiber, a first coreless optical fiber, a GRIN optical fiber and a second coreless optical fiber which are sequentially connected, wherein the top end of the second coreless optical fiber is provided with a polishing surface with a 45-degree inclination angle, the optical fiber probe also comprises a metal coating arranged on the polishing surface, and the position of the metal coating corresponds to the position of the scanning window so that incident light reflected by the metal coating is emitted from the scanning window.
In one embodiment, the OCT imaging system includes: a light source for providing broadband near-infrared incident light; the optical fiber coupler is connected with the light source, the reference arm and the sample arm through optical fibers; one end of an optical fiber of the sample arm is connected with the optical fiber coupler, and the other end of the optical fiber of the sample arm is connected with the optical fiber exposed out of the tail end of the probe; the optical fiber end of the reference arm is connected with the optical fiber coupler; the reflecting unit is arranged at the other end of the optical fiber of the reference arm and used for reflecting the light emitted from the other end of the optical fiber of the reference arm back to the other end of the optical fiber of the reference arm; the spectrometer is connected with the optical fiber coupler through an optical fiber; the computer comprises frequency domain signal analysis software and is used for restoring the frequency domain interference signals into time domain interference signals and then generating OCT images; the optical fiber coupler is used for evenly distributing broadband near-infrared incident light provided by the light source to the reference arm and the sample arm, and is also used for enabling reflected light returned by the sample arm and reflected light returned by the reference arm to meet and interfere in the optical fiber coupler, enabling interference signals generated by interference to enter the spectrometer through optical fibers, and the spectrometer is used for obtaining frequency domain interference signals according to the interference signals and transmitting the frequency domain interference signals to the computer.
When the tissue puncture indicating system based on the lateral scanning OCT endoscopic probe performs puncture, the lateral scanning OCT endoscopic probe is fixedly connected with the rotor of the rotating sleeve ring, the rotating sleeve ring is sleeved on the tube collector, and the puncture injection needle is connected with the second opening of the tube collector, so that the axial relative positions of the lateral scanning OCT endoscopic probe and the puncture injection needle can be kept fixed, and the imaging position of the lateral scanning OCT endoscopic probe is ensured to be consistent with the needle point position of the puncture injection needle. After the puncture is finished, the injection liquid can be added into the inner cavity of the pipe collector through the third opening, so that the injection liquid is injected into the target object through the second pipeline, the first pipeline and the puncture injection needle in sequence, and the injection is realized.
Drawings
For a better understanding of the description and/or illustration of embodiments and/or examples of those inventions disclosed herein, reference may be made to one or more of the drawings. The additional details or examples used to describe the figures should not be considered as limiting the scope of any of the disclosed inventions, the presently described embodiments and/or examples, and the presently understood best modes of these inventions.
FIG. 1 is a schematic diagram of an exemplary fiber optic probe of an ultra-miniature side-scanning OCT endoscopic probe;
FIG. 2 is a schematic structural diagram of an ultra-miniature lateral scanning OCT endoscopic probe assembled by coating the outside of the optical fiber probe of FIG. 1 with a 30G hypodermic needle stem;
FIG. 3 is a schematic structural diagram of a tissue penetration indication system based on a side-scan OCT endoscopic probe in an embodiment;
FIG. 4 is another angled view of the structure shown in FIG. 3;
FIG. 5 is a schematic diagram of the structure of the side-scan OCT endoscopic probe and the rotating collar after it has been extracted from the manifold in one embodiment;
FIG. 6 is a schematic view of an embodiment of a manifold with a needle assembly removed from the side-scan OCT endoscopic probe and the rotating collar, the rotating collar being capable of being screwed onto the rotating collar to close the rotating collar;
FIG. 7 is a schematic diagram of an OCT imaging system in an embodiment;
fig. 8 is a flow chart of a method of operation of a tissue penetration indicating system based on a side-scan OCT endoscopic probe in an embodiment;
fig. 9 is a flowchart of the operation of the tissue puncture indication system based on the side scanning OCT endoscopic probe in the clinical venipuncture injection process in one embodiment.
Detailed Description
To facilitate an understanding of the invention, the invention will now be described more fully with reference to the accompanying drawings. Preferred embodiments of the present invention are shown in the drawings. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
It will be understood that when an element or layer is referred to as being "on," "adjacent to," "connected to," or "coupled to" other elements or layers, it can be directly on, adjacent to, connected or coupled to the other elements or layers or intervening elements or layers may be present. In contrast, when an element is referred to as being "directly on," "directly adjacent to," "directly connected to" or "directly coupled to" other elements or layers, there are no intervening elements or layers present. It will be understood that, although the terms first, second, third, etc. may be used to describe various elements, components, regions, layers and/or sections, these elements, components, regions, layers and/or sections should not be limited by these terms. These terms are only used to distinguish one element, component, region, layer or section from another element, component, region, layer or section. Thus, a first element, component, region, layer or section discussed below could be termed a second element, component, region, layer or section without departing from the teachings of the present invention.
Spatial relational terms such as "under," "below," "under," "above," "over," and the like may be used herein for convenience in describing the relationship of one element or feature to another element or feature as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, then elements or features described as "below" or "beneath" other elements or features would then be oriented "above" the other elements or features. Thus, the exemplary terms "under" and "under" can encompass both an orientation of above and below. The device may be otherwise oriented (rotated 90 degrees or at other orientations) and the spatial descriptors used herein interpreted accordingly.
The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms "comprises" and/or "comprising," when used in this specification, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof. As used herein, the term "and/or" includes any and all combinations of the associated listed items.
OCT is a three-dimensional imaging technique that was born in 1991, and its spatial resolution can reach the micrometer level, and has been widely used in biomedical research, industrial material inspection, jewelry identification, and other fields. Because OCT mostly adopts near-infrared light as incident light, its imaging depth in opaque tissue and material is only 1 ~ 3 millimeters. Therefore, OCT imaging of deep regions inside opaque tissues can only be aided by endoscopic OCT techniques. The early lateral scanning endoscopic OCT technique uses an optical probe with a large diameter and a large length, and the probe is inserted into a natural lumen structure such as a trachea, an esophagus, and a blood vessel, so that the inner wall of the lumen where the probe is located is imaged and scanned by incident light emitted from the side surface of the probe and perpendicular to the main axis direction of the probe. When the optical probe completes 360-degree rotation around the main axis of the probe in the lumen, the lateral incident light can complete the scanning of the tissue structure in the circular plane vertical to the main axis of the probe. When the optical probe completes translation along the main axis of the probe in the lumen, the lateral incident light can complete rotation scanning of a plurality of positions along the translation direction of the probe, thereby obtaining a cylindrical three-dimensional image.
Since the relatively large-sized side-scanning OCT endoscopic probe can only scan the inside of a natural lumen structure, a side-scanning OCT endoscopic probe capable of penetrating into the inside of a non-lumen structure is required for OCT endoscopic imaging at a deep position inside the non-lumen structure opaque tissue. An exemplary OCT endoscopic probe employs a design that places an optical probe connected to an OCT imaging system inside a 30gauge (30G) hypodermic needle shaft. The main components that make up the optical probe are optical fibers, typically formed by fusion splicing of single mode, coreless, and gradient index (GRIN) fibers. Wherein the lengths of the coreless fiber and the gradient index fiber are precisely controlled (within a length error of 5 microns) to ensure that the incident light has a proper working distance and beam spot diameter after exiting from the fiber tip. Subsequently, the incident light emerging from the tip of the fiber needs to be deflected by 90 degrees so as to remain perpendicular to the probe principal axis direction to achieve lateral scanning. In the earlier reported side-scanning OCT endoscopic probe, the designer achieved deflection of the incident light by placing a mirror or prism with a 45 degree angled reflecting surface on the tip of the fiber. However, the size of the mirror or prism is larger, so that the size of the OCT endoscopic probe is also larger, and the damage caused by the endoscopic probe when the endoscopic probe punctures the tissue is increased.
The subsequent ultra-miniature side-scanning OCT endoscopic probe abandons the optical path design based on a reflector or a prism, and a section of coreless optical fiber is additionally welded at the top end of the original optical fiber probe, the top end of the section of coreless optical fiber is ground and polished at an inclination angle of 45 degrees, and then the polished surface is covered with a metal coating (such as a Cr-Au metal coating). Therefore, the incident light converged by the gradient index fiber can be reflected by the metal-coated surface with the inclination angle of 45 degrees, and then 90-degree deflection is realized. Referring to fig. 1, the optical fiber probe is based on an all-fiber design, and can converge and deflect incident light by 90 degrees (d) after (a) welding, (b) grinding and polishing at an inclination angle of 45 degrees, and (c) covering a polishing surface with a metal layer. Referring to fig. 2, the full-fiber optical fiber probe 20 is placed in a 30G hypodermic needle stem 32, and a hole is opened on the side surface of the needle stem to serve as a scanning window 31, so that incident light is emitted in a direction perpendicular to the main axis of the needle stem (near-infrared incident light 11), and the assembly of the side-scanning OCT endoscopic probe is completed. The fiber-optic probe 20 is fixedly connected with an elongated 30G hypodermic needle stem 32 by using an adhesive 12, and the needle tip of the hypodermic needle is sealed by using the adhesive 12. The optical path based on the all-fiber design obviously reduces the size of the optical probe, thereby reducing the size of the whole OCT endoscopic probe and realizing the minimization of the damage caused by the OCT endoscopic probe penetrating into the tissue. The inventor of the application applies the ultra-miniature side scanning OCT endoscopic probe to imaging of the internal structure of the skeletal muscle in 2014, and proves the capability of the probe in identifying different types of biological tissues and imaging the internal structure of the tissues.
An ultra-miniature side-scanning OCT endoscopic probe is a probe which is made by using a side optical fiber probe connected with an OCT imaging system as a main internal optical element and coating the side optical fiber probe with a lengthened 30G hypodermic needle stem. Wherein, the side of the lengthened 30G hypodermic needle stem is provided with an opening, and the position of the opening corresponds to the top end of the lateral optical fiber probe. The incident light entering the lateral fiber probe is reflected at the top end of the fiber probe and then is emitted from the side surface of the fiber probe along the direction vertical to the main axis of the fiber, and then enters the imaged tissue along the direction vertical to the main axis of the needle stem through the opening on the side surface of the needle stem of the injection needle. Therefore, the probe can be penetrated into biological tissues, and three-dimensional endoscopic imaging of the tissues is realized through a scanning mode of rotating around the direction of the main axis of the probe and translating along the direction of the main axis of the probe. The outer diameter of the needle stem of the lengthened 30G hypodermic needle is only 0.3112 mm, so that the volume of the probe is smaller than that of any other side scanning OCT endoscopic probe reported in the world at present, and the probe is an ultra-miniature side scanning OCT endoscopic probe. The probe can minimize damage caused by tissue penetration.
The combination of the lateral scanning endoscopic OCT technique and the clinical venipuncture injection technique will face the following problems:
1. the side-scanning OCT endoscopic probe cannot access injection liquid for intravenous injection, so that an intravenous puncture injection needle must be used at the same time. In this case, how can it be ensured that the relative position of the OCT endoscopic probe and the venipuncture needle in the axial direction can be kept constant throughout the entire puncture procedure before the venipuncture is completed? If the point cannot be guaranteed, the imaging position of the OCT endoscopic probe is inconsistent with the position of the top end of the vein puncture injection needle, so that the indication of the position of the top end of the puncture injection needle cannot be realized according to the imaging result of the OCT endoscopic probe.
2. After the venipuncture is completed, the OCT endoscopic probe needs to be removed because intravenous injection needs to be started immediately. How is it guaranteed that air is not introduced into the vein when the OCT endoscopic probe is removed, and that the OCT endoscopic probe can be reused?
The application combines the ultramicro lateral scanning OCT endoscopic probe with the existing clinical venipuncture injection needle, and utilizes the OCT endoscopic probe to realize the venipuncture indication for the instant imaging of tissues around the top end of the venipuncture injection needle. Fig. 3 is a schematic structural diagram of a tissue puncture indication system based on a side-scanning OCT endoscopic probe in an embodiment, and fig. 4 is a view of the structure shown in fig. 3 from another angle. In the embodiment shown in fig. 3, the tissue penetration indication system based on the side-scan OCT endoscopic probe comprises a collector 310, a puncture needle 320, a rotating collar 330 and a side-scan OCT endoscopic probe 340. Fig. 3 shows the structure of the indicating system during tissue penetration, in order to ensure that the relative positions of the side-scanning OCT endoscopic probe 340 and the penetrating needle 320 in the axial direction are kept fixed, the present application inserts the whole side-scanning OCT endoscopic probe 340 into the needle stem of the penetrating needle 320, and makes the portion of the top end (i.e. the needle point) of the side-scanning OCT endoscopic probe 340 with the scanning window protrude from the top end (i.e. the needle point) of the penetrating needle 320, so that the near-infrared incident light can exit from the side of the needle point of the penetrating needle 320 (the black arrow in fig. 3, 4 and 5 indicates the position of the scanning window). The following describes the indication system, specifically a venipuncture indication system based on a super-miniature side-scanning OCT endoscopic probe, for indicating venipuncture.
The header 310 has a hollow interior cavity including a first conduit 311 communicating from a first side of the header 310 (left side of the header 310 in fig. 3) to a second side (right side of the header 310 in fig. 3). The first pipe 311 forms a first opening at the first side and a second opening at the second side. The hollow interior also includes a second conduit 313 in communication with the first conduit 311. The second pipe 313 has a third opening formed in an outer surface of the manifold 310, and the third opening serves as an injection solution supply port to which an intravenous line can be connected to supply an injection solution into the second pipe 313. Referring also to fig. 6, the header 310 further includes a rotation connection 314 disposed at the first opening position.
The tail end of the needle shaft of the puncture injection needle 320 is inserted into the second opening of the collector 310, and the inner cavity of the needle shaft of the puncture injection needle 320 is communicated with the first pipeline 311 through the second opening. In one embodiment of the present application, the piercing needle 320 is an intravenous piercing needle. In one embodiment of the present application, the needle 320 is of a replaceable design, i.e., a new needle 320 can be pulled out of the manifold 310 and inserted for reuse of the manifold 310.
In the embodiment shown in fig. 3, the rotating collar 330 fits over the rotating connection 314. The rotating collar 330 comprises a rotor having an axis of rotation parallel to the main axis of the shaft of the piercing injection needle 320. The side-scan OCT endoscopic probe 340 is fixedly connected to the rotor, and the structure of the side-scan OCT endoscopic probe 340 may be the same as that of the side-scan OCT endoscopic probe shown in fig. 2. Referring to fig. 3, the rotor inside the rotating collar 330 may still remain laterally fixed relative to the header 310 as it rotates. Since the side-scanning OCT endoscopic probe 340 is fixedly connected to the rotor of the rotating collar 330, and the puncture needle 320 is also fixed to the collector 310, when the rotor drives the side-scanning OCT endoscopic probe 340 to rotate, the relative position of the side-scanning OCT endoscopic probe 340 and the puncture needle 320 in the axial direction can be kept fixed.
As shown in fig. 3, when performing tissue puncture, the probe tail end of the side-scan OCT endoscopic probe 340 is exposed from the end of the rotating collar 330 facing away from the collector 310, the side-scan OCT endoscopic probe 340 extends from the inside of the first conduit 311 into the shaft inner cavity of the puncture needle 320, and the scanning window at the probe tip protrudes from the tip of the puncture needle 320. When clinical vein puncture is performed, the side-scanning OCT endoscopic probe 340 keeps the state of being inserted into the needle shaft of the puncture needle 320, and the probe is driven by the rotating collar 330 fixed at the tail end of the side-scanning OCT endoscopic probe 340 to perform rotary scanning. The scanning result is displayed in real time by the OCT imaging system which is connected with the side scanning OCT endoscopic probe 340 through the optical fiber. When the scanning result of the scanning OCT endoscopic probe 340 indicates that the piercing needle 320 has entered the target blood vessel (i.e., the venipuncture is completed), the operator then pulls the side-scanning OCT endoscopic probe 340 out of the needle shaft lumen of the piercing needle 320 and the first tube 311 together with the rotating collar 330. After the puncture is finished, the injection liquid can be added into the inner cavity of the header 310 through the third opening, so that the injection liquid is injected into the target object through the second pipeline 313, the first pipeline 311 and the puncture injection needle 320 in sequence, and the injection is realized.
Referring also to fig. 6, in this embodiment, the tissue penetration indicating system based on the side-scan OCT endoscopic probe further includes a screw cap 350. The screw cap 350 is used to cover the rotary connection 314 when the rotary collar 330 and the side-scanning OCT endoscopic probe 340 are separated from the manifold 310 (e.g., pulled out of the manifold 310), thereby sealing the first opening. I.e., after piercing is completed, the first opening of the header 310, which previously engaged the rotating collar 330, is sealed with a screw cap 350. In one embodiment of the present application, the lumen of the manifold 310 is already filled with medical fluid (e.g., infusion fluid) and/or saline at the time of tissue penetration to exclude air from the hollow lumen. Since the hollow lumen is always filled with medical solution and/or physiological saline, air will not enter the hollow lumen of the collector 310 or the needle shaft of the puncture needle 320 during the process of pulling out the side-scan OCT endoscopic probe 340 and the rotating collar 330. At this point, the drip infusion into the target vessel can begin via the intravenous tubing connected to the third opening of the manifold 310.
In the embodiment shown in fig. 3, the third opening of concentrator 310 is formed on the first side (i.e., the left side of concentrator 310 in fig. 3).
In the embodiment shown in fig. 6, the manifold 310 includes a body portion 312 having the hollow interior, and a cylindrical swivel connection 314. The rotation connection portion 314 is hollow to serve as one end of the first pipe 311. And the body 312 has a rectangular parallelepiped shape.
In one embodiment of the present application, the rotating collar 330 has a first cylindrical cavity with an inner diameter matching the outer diameter of the rotating connection 314 at a first end (i.e., the end connected to the manifold 310); the second end of the rotating collar 330 is further opened with a second cylindrical cavity communicated to the first cylindrical cavity, and the inner diameter of the second cylindrical cavity matches with the outer diameter of the lateral scanning OCT endoscopic probe 340, so that the lateral scanning OCT endoscopic probe 340 can be fixed in the second cylindrical cavity.
In one embodiment of the present application, the lateral scanning OCT endoscopic probe 340 includes:
the endoscopic probe needle stem is made of a lengthened 30G hypodermic needle, and a scanning window is arranged on the side surface close to the needle tip.
The optical fiber probe stretches into and is fixed in the syringe needle is done, including single mode fiber, first coreless fiber, GRIN (refractive index gradient) optic fibre, the second coreless fiber that connects gradually, second coreless fiber is formed with the polished surface at the top at 45 degrees inclinations, the optical fiber probe is still including locating the metallic coating of polished surface, the position of metallic coating with the position of scanning window is corresponding so that by the light that the metallic coating reflects is followed scanning window jets out.
The elongated hypodermic needle shaft used to make the endoscopic probe shaft cannot be too thick or too thin. Too thin a shaft may result in the inability of the fiber optic probe to be inserted into the shaft lumen of the endoscopic probe, and too thick a shaft may result in the inability of the endoscopic probe to be inserted into the shaft lumen of the intravenous puncture needle. In one embodiment of the present application, the fiber optic probe is 0.125 mm in diameter and the intravenous needle is typically a 22 gauge needle. Because the outer diameter of the lengthened 30G hypodermic needle is 0.3112 mm, and the inner diameter is 0.159 mm (which is larger than the diameter of the optical fiber by 0.125 mm), the lengthened 30G hypodermic needle can be used for preparing an endoscopic probe needle stem. Since the elongated 31G hypodermic needle has an outer diameter of 0.2604 mm and an inner diameter of 0.133 mm (still greater than 0.125 mm of the fiber diameter), the endoscopic probe shaft can also be made based on the elongated 31G hypodermic needle in another embodiment. However, if the inside diameter of the hypodermic needle shaft used to prepare the endoscopic probe shaft is too close to the diameter of the optical fiber, the optical fiber probe cannot be inserted into the shaft cavity if the inside diameter of the hypodermic needle shaft is slightly smaller in practical size. Even if the actual size of the dry internal diameter of hypodermic needle meets the standard, namely the optical fiber probe can be inserted into the dry cavity of hypodermic needle, the operational difficulty of the insertion process is also very high. The reason is that the optical fiber probe is slightly inclined in the process of being inserted into the needle shaft cavity, so that the optical fiber probe collides with the inner wall of the needle shaft, and then the tip of the optical fiber probe can be damaged, so that the sensitivity of the optical fiber probe is damaged, and even the optical fiber probe is directly scrapped. The endoscopic probe shaft prepared by the lengthened 30G hypodermic needle can ensure that the optical fiber probe can be smoothly inserted into the shaft cavity of the hypodermic needle to the maximum extent and ensure that the endoscopic probe is small enough to insert the shaft cavity of the endoscopic probe into the shaft cavity of the 22G venipuncture needle.
In one embodiment of the present application, the tissue puncture indication system based on the side-scan OCT endoscopic probe is a vein puncture indication system based on a super-miniature side-scan OCT endoscopic probe, the side-scan OCT endoscopic probe 340 is a super-miniature side-scan OCT endoscopic probe, and the outer diameter is 0.31 mm (30G hypodermic needle); the puncture needle 320 is a vein puncture needle commonly used in clinic, and the inner diameter of the inner cavity of the needle stem is 0.41 mm, so that the side scanning OCT endoscopic probe 340 can be easily inserted into the inner cavity of the needle stem of the puncture needle 320, and can complete rotary scanning. In order to ensure that air does not enter the puncture needle 320 during the process of completing the puncture indication and removing the side-scan OCT endoscopic probe 340, the present application designs the manifold 310 having a hollow inner cavity and first to third openings, which can simultaneously connect the side-scan OCT endoscopic probe 340, the puncture needle 320 and the intravenous tube. During the entire venipuncture and the beginning of the intravenous injection procedure, the hollow interior of the hub 310 is always filled with the injection solution or saline, thereby precluding the possibility of air entering the needle 320 through the hollow interior of the hub 310. Meanwhile, the operation of inserting and extracting the side-scan OCT endoscopic probe 340 into and from the needle shaft of the puncture injection needle 320 can be easily realized by the collector 310, and the side-scan OCT endoscopic probe 340 is not damaged, so that the side-scan OCT endoscopic probe 340 can be reused.
The OCT imaging system in the tissue puncture indication system based on the side-scan OCT endoscopic probe may adopt a structure known to those skilled in the art. FIG. 7 is a schematic structural diagram of an OCT imaging system in an embodiment, the OCT imaging system comprising:
a light source for providing broadband near-infrared incident light. In one embodiment of the present application, superluminescent diodes are employed as the light source for the system.
And the optical fiber coupler is connected with the light source, the reference arm and the sample arm through optical fibers.
And one end of the optical fiber of the sample arm is connected with the optical fiber coupler, and the other end of the optical fiber of the sample arm is connected with the optical fiber exposed out of the tail end of the probe.
And one end of the optical fiber of the reference arm is connected with the optical fiber coupler.
And the reflecting unit is arranged at the other end of the optical fiber of the reference arm and used for reflecting the light emitted from the other end of the optical fiber of the reference arm back to the other end of the optical fiber of the reference arm. The reflection unit may be a mirror.
And the spectrometer is connected with the optical fiber coupler through an optical fiber.
And the computer comprises frequency domain signal analysis software and is used for reducing the frequency domain interference optical signal into a time domain interference optical signal and then generating the OCT image.
The optical fiber coupler is used for evenly distributing broadband near-infrared incident light provided by the light source to the reference arm and the sample arm, and is also used for enabling reflected light returned by the sample arm and reflected light returned by the reference arm to meet and interfere in the optical fiber coupler, enabling interference signals generated by interference to enter the spectrometer through optical fibers, and the spectrometer is used for obtaining frequency domain interference signals according to the interference signals and transmitting the frequency domain interference signals to the computer.
Specifically, the OCT imaging system connected with the ultra-miniature side scanning endoscopic probe is assembled by an optical fiber and an optical element. The super light emitting diode is used as a light source of the system and provides broadband near infrared incident light (with the central wavelength of 1310 nanometers and the frequency bandwidth of 75 nanometers) for the system. The incident light is emitted from the light source, enters the fiber coupler along with the optical fiber, and is then evenly distributed to the optical fibers of the reference arm and the sample arm. Incident light entering the reference arm is reflected via a mirror and returned to the fiber coupler again through the fiber of the reference arm. The incident light entering the sample arm enters the endoscopic probe through the optical fiber, is deflected by 90 degrees after being reflected by a 45-degree inclined end face in the endoscopic probe, and is focused at a position 300-400 microns away from the side surface of the endoscopic probe. The beam of sample arm incident light is reflected by the sample (e.g., blood) and then returned to the fiber coupler via the endoscopic probe and the optical fiber in the sample arm. Thus, the reflected light from the reference arm and the reflected light from the sample arm meet and interfere in the fiber coupler, thereby generating an interference signal containing information about the structure of the sample (the reflected light from the sample arm). The interference signal enters the spectrometer from the optical fiber coupler to generate a frequency domain interference signal. The frequency domain interference signals are subjected to fast Fourier transform in a computer and are restored into time domain interference signals, and then the scanned samples are subjected to real-time two-dimensional imaging, so that the identification of the top end of the endoscopic needle and the tissues around the top end of the puncture injection needle is realized, and the puncture injection needle is positioned.
According to the tissue puncture indicating system based on the lateral scanning OCT endoscopic probe, the lateral scanning OCT endoscopic probe is applied to scan tissues around the top end of the venipuncture injection needle, the type of the tissues around the top end of the venipuncture injection needle is judged according to the instant imaging result, and puncture indication can be achieved. Compared with the puncture indication based on the electrical impedance value and the mechanical resistance value at the top end of the vein puncture needle, the puncture indication is more reliable and is not easily interfered by non-puncture position factors. Meanwhile, the puncture instruction based on OCT endoscopic imaging can be used in cooperation with the vein puncture navigation technology based on medical images, so that the defect that the puncture instruction cannot be completed by the two-dimensional medical images in the direction vertical to the imaging plane is overcome.
The application correspondingly provides an operation method of a tissue puncture indicating system based on a side scanning OCT endoscopic probe. Fig. 8 is a flowchart of an operation method of the tissue puncture indication system based on the side scanning OCT endoscopic probe in an embodiment, which includes the following steps:
and S110, inserting the OCT endoscopic probe with the rotary sleeve ring into the inner cavity of the collector and the needle stem of the puncture injection needle, wherein the OCT endoscopic probe is fixedly connected with the rotor of the rotary sleeve ring.
The side scanning OCT endoscopic probe connected with the OCT imaging system is inserted into the hollow inner cavity of the tube collector and the needle stem of the puncture injection needle, and the scanning window at the top end of the side scanning OCT endoscopic probe is ensured to be extended out of the top end of the puncture injection needle. In one embodiment of the application, the operation method is to operate a venipuncture indication system based on a ultramicro lateral scanning OCT endoscopic probe, and the venipuncture is indicated through the system. The structure of the pipe collector can refer to fig. 3 and 4. The hollow interior of the header includes a first conduit communicating from a first side to a second side of the header, the first conduit forming a first opening at the first side and a second opening at the second side. The second opening is connected with the tail end of the needle stem of the puncture injection needle, and the inner cavity of the needle stem of the puncture injection needle is communicated with the first pipeline through the second opening. The hollow inner cavity further comprises a second pipeline communicated with the first pipeline, the second pipeline forms a third opening on the outer surface of the pipe collector, and the third opening is connected with an infusion device. The header further includes a swivel connection disposed at the first open location. Referring to fig. 5, the rotating collar includes a rotor to which the side-scan OCT endoscopic probe is fixedly connected.
And S120, sleeving the rotary sleeve on the rotary connecting part of the pipe collector.
In step S110, while adjusting the position of the side-scan OCT endoscopic probe, a rotating sleeve is sleeved on the rotating connection portion of the tube collector, and a rotating shaft of a rotor of the rotating sleeve is parallel to a main shaft of the puncture needle.
The assembly of the components such as the side-scan OCT endoscopic probe and the tube collector is completed through steps S110 and S120, and then the puncture needle and the side-scan OCT endoscopic probe are inserted into the target tissue, specifically, into the human tissue, to start venipuncture.
S130, the OCT endoscopic probe is driven to rotate by the rotating sleeve ring and is scanned laterally, and an instant scanning result is obtained by the OCT imaging system.
And starting the OCT imaging system, driving the lateral scanning OCT endoscopic probe to rotate by rotating the sleeve ring to perform lateral scanning, and obtaining an instant scanning result by the OCT imaging system.
And S140, if the needle head of the puncture injection needle reaches the target position, pulling out the OCT endoscopic probe and the rotating lantern ring from the manifold device.
And judging whether the needle head of the puncture injection needle reaches the target position according to the instant scanning result obtained by the OCT imaging system, and if so, pulling out the side scanning OCT endoscopic probe and the rotating lantern ring from the manifold device.
In an embodiment of the present application, step S140 includes adjusting the position of the needle and the lateral scanning OCT endoscopic probe in the tissue, and determining the type of the tissue around the tip of the needle according to the instant scanning result obtained by the OCT imaging system, and then determining the position of the tip of the needle. If the judgment result is that the needle head of the puncture injection needle reaches the target position (for example, enters a target blood vessel), the next step is carried out, otherwise, the position of the puncture injection needle (and the side scanning OCT endoscopic probe) in the tissue is continuously adjusted until the target position is reached. In one embodiment, the position of the tip of the needle of the puncture injection needle can be automatically judged by a machine by adopting an image recognition or artificial intelligence technology; in other embodiments, the determination may be made manually by an operator based on the image displayed by the OCT imaging system.
And S150, covering the rotary connecting part with the rotary cover, thereby sealing the first opening of the inner cavity of the header.
The operation of step S150 may refer to fig. 6. In one embodiment of the present application, the lumen of the header is already filled with medical fluid (e.g., injection fluid) and/or saline at the time of tissue penetration to exclude air from the hollow lumen. Because the hollow inner cavity is filled with liquid medicine and/or normal saline all the time, air can not enter the hollow inner cavity of the tube collector or the needle stem of the puncture injection needle in the process of pulling out the side scanning OCT endoscopic probe and the rotating lantern ring. In one embodiment of the present application, the cap is screwed on to start intravenous drip into the target vessel through the intravenous line connected to the third opening of the manifold.
Fig. 9 is a flowchart of the operation of the tissue puncture indication system based on the side scanning OCT endoscopic probe in the clinical venipuncture injection process in one embodiment.
It should be understood that, although the steps in the flowcharts of fig. 8 and 9 are shown in order as indicated by the arrows, the steps are not necessarily performed in order as indicated by the arrows. The steps are not performed in the exact order shown and described, and may be performed in other orders, unless explicitly stated otherwise. Moreover, at least some of the steps in fig. 8 and 9 may include multiple steps or multiple stages, which are not necessarily performed at the same time, but may be performed at different times, which are not necessarily performed in sequence, but may be performed in turn or alternately with other steps or at least some of the other steps.
In the description herein, references to the description of "some embodiments," "other embodiments," "desired embodiments," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, a schematic description of the above terminology may not necessarily refer to the same embodiment or example.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. A tissue puncture indicating system based on a side scanning OCT endoscopic probe is characterized by comprising:
a header having a hollow interior comprising a first conduit communicating from a first side to a second side of the header, the first conduit forming a first opening at the first side and a second opening at the second side, the hollow interior further comprising a second conduit communicating with the first conduit, the second conduit forming a third opening at an exterior surface of the header, the third opening acting as an injection port, the header further comprising a swivel connection disposed at the location of the first opening;
the second opening of the puncture injection needle is used for connecting the tail end of the needle stem of the puncture injection needle, and the inner cavity of the needle stem of the puncture injection needle is communicated with the first pipeline through the second opening;
the rotating sleeve ring is sleeved on the rotating connecting part and comprises a rotor, and a rotating shaft of the rotor is parallel to a needle stem main shaft of the puncture injection needle connected with the second opening;
the side scanning OCT endoscopic probe is fixedly connected with the rotor so as to rotate along with the rotor;
when the rotating sleeve ring is sleeved on the rotating connecting part, the tail end of the probe of the lateral scanning OCT endoscopic probe is exposed out of one end, away from the collector, of the rotating sleeve ring, the lateral scanning OCT endoscopic probe extends into the needle stem internal cavity of the puncture injection needle from the interior of the first pipeline, and the scanning window at the top end of the probe extends out of the top end of the puncture injection needle.
2. The lateral-scanning OCT endoscopic probe-based tissue penetration indicating system of claim 1, further comprising a cap for covering the rotating connection to seal the first opening when the hub is detached from the rotating collar and the lateral-scanning OCT endoscopic probe.
3. The lateral-scanning OCT endoscopic probe-based tissue penetration indicating system of claim 1, wherein the hollow lumen is adapted to be filled with a medical fluid and/or saline solution to exclude air from the hollow lumen when performing a tissue penetration.
4. The lateral-scanning-OCT-based endoscopic probe-based tissue penetration indicating system according to claim 2, wherein the hub includes a main body portion having the hollow lumen, and the rotary connecting portion having a cylindrical shape, which is hollow as one end of the first conduit, the main body portion having an exterior of a rectangular parallelepiped.
5. The lateral-scanning OCT endoscopic probe-based tissue penetration indicating system of claim 4, wherein the rotating collar is further defined at a first end by a first cylindrical cavity having an inner diameter matching an outer diameter of the rotating connection portion, and at a second end by a second cylindrical cavity communicating with the first cylindrical cavity, the inner diameter of the second cylindrical cavity matching an outer diameter of the lateral-scanning OCT endoscopic probe, the lateral-scanning OCT endoscopic probe being secured in the second cylindrical cavity.
6. The lateral-scanning OCT endoscopic probe-based tissue penetration indicating system of claim 1, wherein the third opening is formed in the first side, the second side being an opposite side of the first side.
7. The lateral-scanning OCT endoscopic probe-based tissue penetration indicating system of claim 1, wherein the lateral-scanning OCT endoscopic probe comprises:
the endoscopic probe needle stem is made based on a hypodermic needle stem, and a scanning window is arranged on the side surface close to the needle point;
the optical fiber probe extends into and is fixed in the endoscopic probe needle stem and comprises a single mode optical fiber, a first coreless optical fiber, a GRIN optical fiber and a second coreless optical fiber which are sequentially connected, wherein the top end of the second coreless optical fiber is provided with a polishing surface with a 45-degree inclination angle, the optical fiber probe also comprises a metal coating arranged on the polishing surface, and the position of the metal coating corresponds to the position of the scanning window so that incident light reflected by the metal coating is emitted from the scanning window.
8. The tissue penetration indication system based on the side-scanning OCT endoscopic probe of claim 7, wherein the hypodermic needle shaft is an elongated 30G hypodermic needle shaft.
9. The lateral-scanning OCT endoscopic probe-based tissue penetration indicating system of claim 7, further comprising an OCT imaging system, said OCT imaging system comprising:
a light source for providing broadband near-infrared incident light;
the optical fiber coupler is connected with the light source, the reference arm and the sample arm through optical fibers;
one end of an optical fiber of the sample arm is connected with the optical fiber coupler, and the other end of the optical fiber of the sample arm is connected with the optical fiber exposed out of the tail end of the probe;
the optical fiber end of the reference arm is connected with the optical fiber coupler;
the reflecting unit is arranged at the other end of the optical fiber of the reference arm and used for reflecting the light emitted from the other end of the optical fiber of the reference arm back to the other end of the optical fiber of the reference arm;
the spectrometer is connected with the optical fiber coupler through an optical fiber;
the computer comprises frequency domain signal analysis software and is used for restoring the frequency domain interference signals into time domain interference signals and then generating OCT images;
the optical fiber coupler is used for evenly distributing broadband near-infrared incident light provided by the light source to the reference arm and the sample arm, and is also used for enabling reflected light returned by the sample arm and reflected light returned by the reference arm to meet and interfere in the optical fiber coupler, enabling interference signals generated by interference to enter the spectrometer through optical fibers, and the spectrometer is used for obtaining frequency domain interference signals according to the interference signals and transmitting the frequency domain interference signals to the computer.
10. A method for operating a tissue puncture indication system based on a side scanning OCT endoscopic probe comprises the following steps:
inserting a side-scanning OCT endoscopic probe connected with an OCT imaging system into a hollow inner cavity of a tube collector and a needle stem of a puncture injection needle, and ensuring that a scanning window at the top end of the side-scanning OCT endoscopic probe is extended out from the top end of the puncture injection needle; the hollow inner cavity of the header comprises a first pipeline communicated from a first side to a second side of the header, the first pipeline forms a first opening on the first side and a second opening on the second side, the second opening is connected with the tail end of the needle stem of the puncture injection needle, and the inner cavity of the needle stem of the puncture injection needle is communicated with the first pipeline through the second opening; the hollow inner cavity further comprises a second pipeline communicated with the first pipeline, the second pipeline forms a third opening on the outer surface of the pipe collector, and the third opening is connected with an infusion device; the header further comprises a swivel connection disposed at the first open location;
sleeving a rotating sleeve ring on the rotating connecting part, wherein the rotating sleeve ring comprises a rotor, the lateral scanning OCT endoscopic probe is fixedly connected with the rotor, and a rotating shaft of the rotor is parallel to a needle stem main shaft of the puncture injection needle;
the OCT imaging system works, the lateral scanning OCT endoscopic probe is driven to rotate by the rotating lantern ring to perform lateral scanning, and an instant scanning result is obtained by the OCT imaging system;
if the needle head of the puncture injection needle reaches the target position, pulling out the side-scanning OCT endoscopic probe and the rotating collar from the tube collector;
and covering a rotary cover on the rotary connecting part so as to seal the first opening.
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