CN112768107B - Irradiation treatment equipment and irradiation treatment method based on X rays - Google Patents
Irradiation treatment equipment and irradiation treatment method based on X rays Download PDFInfo
- Publication number
- CN112768107B CN112768107B CN202011546231.4A CN202011546231A CN112768107B CN 112768107 B CN112768107 B CN 112768107B CN 202011546231 A CN202011546231 A CN 202011546231A CN 112768107 B CN112768107 B CN 112768107B
- Authority
- CN
- China
- Prior art keywords
- irradiation
- ray
- beam cross
- section shape
- container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21K—TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
- G21K5/00—Irradiation devices
- G21K5/04—Irradiation devices with beam-forming means
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E30/00—Energy generation of nuclear origin
- Y02E30/30—Nuclear fission reactors
Abstract
The invention relates to an X-ray-based irradiation treatment device and an X-ray-based irradiation treatment method, and belongs to the technical field of medical instruments. The device comprises a shielding shell for enclosing an irradiation cavity, an X-ray tube, an irradiation container and a rotary driver; the shielding shell is provided with a ray passing hole, and the X-ray tube emits X-rays for irradiation to the irradiation cavity through the ray passing hole; the cross section of the irradiation X-ray beam irradiating the irradiation container is provided with two opposite side boundary lines, the two side boundary lines are arranged along the axial direction of the rotation axis, and the rotation axis is positioned in the irradiation range of the irradiation X-ray beam; and the lower end of the beam boundary defined by the boundary lines on two sides is positioned at the lower side of the bottom surface of the effective accommodating cavity of the irradiation container in the axial direction; the irradiation area of the irradiation X-ray beam in the accommodating cavity is smaller than the accommodating area of the accommodating cavity on a transverse surface with the surface normal direction arranged along the axial direction. The irradiation treatment equipment has high irradiation uniformity and can be widely applied to the production field of blood products.
Description
Technical Field
The invention relates to the technical field of irradiation treatment, in particular to an irradiation treatment device based on X-rays and an irradiation treatment method suitable for the device.
Background
The irradiation treatment technology is a technology for carrying out irradiation treatment on materials, foods, blood or seed to be irradiated by using a high-energy ray irradiation method, common high-energy rays can be divided into gamma rays and X rays, gamma ray irradiation treatment equipment generally uses Cs-137 or Co-60 as a radioactive source, and X ray irradiation treatment equipment generally adopts X rays for irradiation treatment; the object to be irradiated to be treated is different from the object, and the type and the dosage of the used rays are generally different; the technology specifically uses the interaction between rays and substances to ionize and excite the generated activated atoms and activated molecules to make them generate a series of physical, chemical or biochemical changes with the substances, so as to degrade, polymerize, crosslink and modify the substances. The X-ray is used as the high-energy ray for irradiation, so that the advantage of no ray generation in the non-working state can be fully utilized.
Currently, in clinical treatment, one of the mature application technologies is to irradiate blood products with the irradiation treatment technology, because complications related to transfusion may occur during transfusion, wherein graft versus host disease is taken as the most serious adverse reaction of transfusion, and currently, no specific treatment method exists, and irradiation of blood with radiation can effectively prevent the serious adverse reaction.
The blood irradiation instrument is used as medical equipment for irradiating blood, and has the working principle that high-energy gamma rays or x-rays are utilized to inactivate T lymphocytes with immunological activity in the blood, but the effects on the functions of red blood cells and platelets and the activity of clotting factors are not great, and the blood irradiation instrument specifically comprises a bracket, an industrial personal computer, a control panel, a high-voltage generator, a ray generator, a shielding shell for enclosing an irradiation cavity, a carrier tray rotatably arranged in the irradiation cavity and a rotary driver for driving the carrier tray to rotate, wherein the structure of the carrier tray is shown in the technical scheme disclosed in patent documents such as CN106620910A, CN111803735A and the like; in the working process, the ray generator emits high-energy rays to the irradiation cavity through the ray passing holes arranged on the shielding shell so as to irradiate blood products in the blood cup arranged on the carrying tray, thereby achieving the aim of extinguishing T lymphocytes.
In the patent document with the publication number of CN106620910A, the blood in the blood bag forms accumulated dose by arranging the blood cup autorotation mechanism, if the blood cup does not rotate, the radiation dose absorbed by the edge of the blood cup close to the radiation source is far greater than the edge of the blood cup far away from the radiation source, the uniformity of the radiation absorbed dose is unacceptable, and compared with the scheme of non-rotating radiation, the uniformity is obviously improved; however, during actual use, the applicant found that the radial distribution of the cumulative amount of radiation dose of the blood cup along the radial direction thereof is very uneven, and as shown in fig. 1, the result of calculation based on the following calculation formula 1 is that the cumulative amount of radiation dose in the region of the rotation axis 10 is greatly different from that in the outer region, and the greatest difference can reach (3.42-2.47)/2.47=38.5%, and the uniformity is poor. Referring to the schematic structural diagram of the blood irradiator shown in fig. 2, the calculation formula 1 is specifically as follows:
at the upper partIn the formula, the formula n=n is satisfied for attenuation in a substance based on X-rays 0 Be -ux Wherein the accumulation factor B can be calculated by using the berkovich formula (empirical formula), b=1+auxe bux The method comprises the steps of carrying out a first treatment on the surface of the As shown in fig. 2, O is a rotation center of the blood cup, that is, the blood cup 01 rotates around the rotation axis 10, the radius is 100 mm, P is a radiation source point, M is any test point in the cup, E is an intersection point of a connecting line between the radiation source point P and any test point M and the inner wall of the blood cup, θ is an included angle between OM and OP, op=h, om=r, oe=r, and pm=h; and can be expressed by the following formula according to the attenuation of X-rays in a substance: n=n 0 Be -ux Wherein the accumulation factor B can be calculated by using the berkovich formula (empirical formula), b=1+auxe bux Thus in the static case, the M-point dose can be expressed as shown in the following equation 2:
whereas equation 1 above is the radiation dose accumulated by equation 2 over a complete revolution of blood. In order to solve the problem of uneven accumulation of irradiation dose, the applicant modified the blood and its driving structure as disclosed in the above patent document with publication No. CN111803735a, i.e. a structure in which a large blood cup is sleeved with a small blood cup, while improving the uniformity of accumulation of irradiation dose, the effective accommodation amount of the blood cup is made to be the sum of the four small blood cup capacities, i.e. not only the reduction of the overall effective capacity thereof is caused, but also the structure of the rotation driving mechanism is made more complicated and the equipment cost is increased.
Disclosure of Invention
The invention mainly aims to provide an irradiation treatment device based on X-rays, so as to improve the irradiation treatment uniformity of an object to be irradiated on the premise of not reducing the existing irradiation capacity;
another object of the present invention is to provide an irradiation treatment method so that an irradiation treatment apparatus based on the method improves uniformity of irradiation treatment of an object to be irradiated without reducing an existing irradiation capacity.
In order to achieve the main purpose, the irradiation treatment equipment provided by the invention is based on X rays, and the specific structure comprises a shielding shell for enclosing an irradiation cavity, an X ray tube positioned outside the irradiation cavity, an irradiation container arranged in the irradiation cavity, and a rotary driver for driving the irradiation container to rotate around a rotary axis; the shielding shell is provided with a ray passing hole, and the X-ray tube emits X-rays for irradiation to the irradiation cavity through the ray passing hole; the cross section of the irradiation X-ray beam irradiating the irradiation container is provided with two opposite side boundary lines, the two side boundary lines are arranged along the axial direction of the rotation axis, and the rotation axis is positioned in the irradiation range of the irradiation X-ray beam; and the lower end of the beam boundary defined by the boundary lines on two sides is positioned at the lower side of the bottom surface of the effective accommodating cavity of the irradiation container in the axial direction; the irradiation area of the irradiation X-ray beam in the accommodating cavity is smaller than the accommodating area of the accommodating cavity on a transverse surface with the surface normal direction arranged along the axial direction.
In the technical scheme, the irradiation beam is provided with two side boundary surfaces so as not to completely irradiate the effective accommodating area in the irradiation container, and at least the near area of the rotation axis can be irradiated by the irradiation beam, so that the uniformity of irradiation treatment can be improved on the premise of keeping the existing irradiation capacity.
The specific scheme is that the ratio of the irradiation area to the accommodation area is 0.3 to 0.85. The technical scheme can further improve the uniformity of irradiation.
More specifically, the ratio of the irradiation area to the receiving area is 0.6 to 0.75. The technical scheme can further improve irradiation uniformity.
The upper end of the beam boundary defined by the boundary lines on both sides is preferably located on the upper side of the cavity top surface of the effective accommodating cavity of the irradiation container in the axial direction. According to the technical scheme, the condition that the container exceeds the accommodating cavity of the container due to the fact that the container contains too much objects to be irradiated can be effectively avoided, and therefore irradiation uniformity and effect are effectively ensured.
The preferred scheme is that a ray beam cross section shape adjusting mechanism is arranged on a ray traveling path of X rays from an X ray tube to an irradiation container; the beam cross-section shape adjusting mechanism has a beam cross-section shape shaping opening defined by the lead plate boundary, and the beam cross-section after being adjusted by the beam cross-section shape shaping opening has two side boundary lines. The technical scheme can effectively simplify the structure of the X-ray tube, namely, the cross section structure of the emergent ray beam of the X-ray tube is not required to be limited.
The further proposal is that the ray passing hole is a circular hole structure, and the ray beam cross section shape shaping opening is a ray beam cross section shape adjusting hole; the beam cross section shape adjusting mechanism is provided with a sleeve bracket sleeved in the beam passing hole and a hole-distributing lead plate fixed on the sleeve bracket; the hole-distributing lead plate is a circular lead plate provided with a beam cross section shape adjusting hole; the beam cross section shape adjusting hole is provided with two strip boundaries which are arranged along the axial direction, and an upper side connecting boundary and a lower side connecting boundary which are used for connecting the same side end parts of the two strip boundaries; the two strip boundaries are arranged oppositely and are used for enabling the X-ray beam for irradiation to have two side boundary lines; the sleeve bracket comprises a small-diameter sleeve barrel part sleeved in the ray passing hole, and a large-diameter sleeve barrel part with an inner hole for sleeving the round lead plate; a stepped end surface abutting against the side surface of the shielding shell is formed at the joint of the two sleeve barrel parts, so that the projection of the circular lead plate on the side surface completely covers the ray passing hole.
The further scheme is that the beam cross section shape adjusting mechanism is provided with more than two beam cross section shape shaping ports which are sequentially arranged along the extending direction of the travelling path and used for sequentially adjusting the cross section shape of the same beam; and the X-ray beam after being regulated by the upstream side shaping port is regulated by the downstream side shaping port along the direction of the X-ray tube pointing to the irradiation container, so that the two side boundary lines on the regulated X-ray beam are provided with inward offset. The technical scheme can effectively improve the flatness of the beam boundary so as to further improve the irradiation uniformity.
The rotation axis is preferably located on the beam symmetry plane, and the two side boundary surfaces of the irradiation X-ray beam are symmetrically arranged with respect to the beam symmetry plane, the two side boundary surfaces being formed by two side boundary lines extending in the ray direction. The technical scheme can further improve the uniformity of irradiation treatment.
The preferred solution is to arrange axially and vertically.
The preferred solution is that the number of irradiation beams is a single beam. The technical scheme can further improve irradiation uniformity.
The preferable scheme is that the irradiation container is of a straight cylinder structure which is axially extended in the height direction. The technical scheme can further improve irradiation uniformity.
The preferred solution is that the boundary lines on both sides are arranged in the axial direction of the rotation axis such that the amplitude of the fluctuation of the boundary lines on both sides in the transverse direction perpendicular to the axial direction is less than 5% of the diameter of the container, which is the equivalent straight cylinder diameter of the irradiation container. The technical scheme can further improve irradiation uniformity.
A further solution is that the borderlines on both sides are straight lines.
In order to achieve the other purpose, the irradiation treatment method provided by the invention uses high-energy rays to irradiate the object to be irradiated which is contained in the irradiation container, and in the irradiation treatment process, the irradiation container is driven to drive the object to be irradiated to rotate around the rotation axis; the cross section of the irradiation ray beam composed of the high-energy rays is provided with two side boundary lines which are oppositely arranged, the two side boundary lines are both arranged along the axial direction of the rotation axis, and the rotation axis is positioned in the irradiation range of the irradiation ray beam; and the lower end of the beam boundary defined by the boundary lines on two sides is positioned at the lower side of the bottom surface of the effective accommodating cavity of the irradiation container in the axial direction; the irradiation area of the irradiation beam in the accommodating cavity is smaller than the accommodating area of the accommodating cavity on a transverse surface with a surface normal direction arranged along the axial direction.
In the technical scheme, the irradiation is performed based on the irradiation beam with the two side boundary surfaces, so that the effective accommodating area in the irradiation container is not completely irradiated, and the irradiation beam can irradiate at least the area nearby the rotation axis, so that the uniformity of irradiation treatment can be improved on the premise of keeping the existing irradiation capacity.
The specific scheme is that the ratio of the irradiation area to the accommodation area is 0.3 to 0.85.
More specifically, the ratio of the irradiation area to the receiving area is 0.6 to 0.75.
The preferred solution is to arrange axially and vertically.
The rotation axis is preferably located on the beam symmetry plane, and the two side boundary surfaces of the irradiation beam are symmetrically arranged with respect to the beam symmetry plane, the two side boundary surfaces being formed by two side boundary lines extending in the radial direction.
The preferred solution is that the number of irradiation beams is a single beam.
The preferable proposal is that the container of the object to be irradiated is a straight cylinder structure which extends along the axial direction along the height direction.
The preferable scheme is that the irradiation treatment method is to irradiate the blood product, and the irradiation container is a blood cup.
The preferred solution is that the boundary lines on both sides are arranged in the axial direction of the rotation axis in such a way that the fluctuation amplitude of the boundary lines on both sides in the transverse direction perpendicular to the axial direction is less than 5% of the diameter of the container, which is an equivalent straight cylinder of the container of the object to be irradiated.
In order to achieve the main purpose, the irradiation treatment equipment provided by the invention is based on X rays, and the specific structure comprises a shielding shell provided with a circular ray passing hole, an X ray tube which emits X rays to an irradiation cavity enclosed by the shielding shell through the ray passing hole, and a rotary driver which is used for driving an object to be irradiated to rotate around a rotary axis in the irradiation treatment process; a beam cross section shape adjusting mechanism is arranged on an X-ray beam advancing path from an X-ray tube to a target irradiation treatment position; the beam cross-section shape adjusting mechanism is provided with a beam cross-section shape shaping opening defined by a lead plate boundary, the irradiation X-ray beam after being adjusted by the beam cross-section shape shaping opening can irradiate the area where the rotation axis is located, the cross section of the irradiation X-ray beam is provided with two side boundary lines which are oppositely arranged, and the two side boundary lines are arranged along the axial direction of the rotation axis; the via ray beam is designed to be an X-ray beam composed of X-rays allowed to pass through the ray passing hole without shielding.
In the above technical solution, if an irradiation container is disposed in the irradiation cavity, the irradiation container makes the irradiation beam not completely irradiate the effective accommodation area in the irradiation container, and the irradiation beam can irradiate at least the vicinity of the rotation axis, so that the uniformity of the irradiation treatment can be improved while maintaining the existing irradiation capacity.
The specific scheme is that a beam shape shaping port is a beam cross section shape adjusting hole; the beam cross-section shape adjusting hole is provided with two strip boundaries which are arranged along the axial direction, and an upper side connecting boundary and a lower side connecting boundary which are used for connecting the same side end parts of the two strip boundaries.
The preferred solution is that the borderlines on both sides of the cross section of the irradiation X-ray beam are arranged symmetrically about a projection axis, which is the projection of the rotation axis onto the cross section of the irradiation X-ray beam.
The preferred scheme is that the beam cross-section shape shaping port is a beam cross-section shape adjusting hole; the beam cross section shape adjusting mechanism is provided with a sleeve bracket sleeved in the beam passing hole and a hole-distributing lead plate fixed on the sleeve bracket; the hole-distributing lead plate is a circular lead plate provided with a beam cross section shape adjusting hole; the beam cross section shape adjusting hole is provided with two strip boundaries which are arranged along the axial direction, and an upper side connecting boundary and a lower side connecting boundary which are used for connecting the same side end parts of the two strip boundaries; the two strip boundaries are arranged oppositely and are used for enabling the X-ray beam for irradiation to have two side boundary lines; the sleeve bracket comprises a small-diameter sleeve barrel part sleeved in the ray passing hole, and a large-diameter sleeve barrel part with an inner hole for sleeving the round lead plate; a stepped end surface abutting against the side surface of the shielding shell is formed at the joint of the two sleeve barrel parts, so that the projection of the circular lead plate on the side surface completely covers the ray passing hole.
The preferred scheme is that the blood irradiator comprises an irradiation container arranged in an irradiation cavity and used for containing an object to be irradiated; the lower end of the beam boundary defined by the boundary lines on both sides is positioned at the lower side of the cavity bottom surface of the effective accommodating cavity of the irradiation container, and the upper end of the beam boundary defined by the boundary lines on both sides is positioned at the upper side of the cavity top surface of the effective accommodating cavity of the irradiation container; and on a transverse surface of the surface normal direction along the axial direction, the irradiation area of the adjusted X-ray beam in the accommodating cavity is smaller than the accommodating area of the accommodating cavity.
A further solution is to have a ratio of irradiation area to receiving area of 0.3 to 0.85.
A still further solution is to have a ratio of irradiation area to receiving area of 0.6 to 0.75.
The preferred solution is to arrange axially and vertically.
The preferred solution is that the number of irradiation beams is a single beam.
The lead plate boundary is preferably straight and arranged parallel to the rotation axis.
Drawings
FIG. 1 is a graph showing the cumulative dose distribution area calculated based on the prior art formula for different positions on opposite radial directions on both sides of a cup during one revolution; wherein the rotation axis 10 is a rotation central axis, and the scale of the horizontal axis from the rotation axis to two sides is the radial distance from the rotation axis 10;
FIG. 2 is a schematic diagram of a conventional blood cup, irradiation beam and radiation generator;
FIG. 3 is a block diagram showing a blood irradiation apparatus according to example 1 of the present invention;
FIG. 4 shows the cumulative amounts of radiation dose at different positions on opposite radial directions on two sides of a blood cup in example 1 of the present invention when the blood cup is rotated one round, wherein the different curves are different corresponding area ratios, and the area ratios are the ratio of the effective irradiation area in the blood cup to the receivable area of the receiving cavity; wherein the rotation axis 10 is a rotation central axis, and the scale of the horizontal axis from the rotation axis to two sides is the radial distance from the rotation axis 10;
FIG. 5 is a graph showing the change in the cumulative irradiation dose change rate in the radial direction of the blood cup according to the area ratio shown in FIG. 4, and the horizontal axis is the value of the area ratio in example 1 of the present invention;
FIG. 6 is an exploded view of a beam cross-sectional shape adjusting mechanism in accordance with embodiment 2 of the present invention;
FIG. 7 is an enlarged view of part A of FIG. 6;
FIG. 8 is a view showing the construction of a sleeve holder according to embodiment 2 of the present invention;
FIG. 9 is a side view of a sleeve holder according to embodiment 2 of the present invention;
fig. 10 is a front view of a lead plate with holes in example 2 of the present invention;
FIG. 11 is a cross-sectional view taken along line B-B of FIG. 10;
FIG. 12 is a schematic view showing the structure of a blood cup, an irradiation beam, a beam cross-sectional shape adjusting mechanism and a radiation generator in example 1 of the present invention;
FIG. 13 is a schematic diagram showing the operation of a beam cross-sectional shape adjusting mechanism in accordance with embodiment 1 of the present invention;
FIG. 14 is a schematic view showing the structure of a blood cup, an irradiation beam, a beam cross-sectional shape adjusting mechanism and a radiation generator in example 3 of the present invention;
FIG. 15 is a view of a single reshaping port reference film image in accordance with example 3 of the present invention;
fig. 16 is a film image of the dual shaping port serial arrangement of example 3 of the present invention.
Detailed Description
The invention is further described below with reference to examples and figures thereof.
The main conception of the invention is that the boundary structure of the X-ray beam for irradiation of the existing blood irradiation instrument is improved, in particular to the ratio of the effective irradiation area of the improved X-ray beam for irradiation to the receivable area of the irradiation container such as a blood cup is less than 1, thereby improving the uniformity of irradiation dose accumulation of the object to be irradiated in the irradiation treatment process; according to the present concept, the blood irradiation instrument and other partial structures of the shielding case may be designed with reference to existing products, and are not limited to the exemplary structures in the following embodiments.
Example 1
As shown in fig. 3 and 12, the blood irradiation instrument of the present invention comprises a mounting bracket, an industrial personal computer, a control panel, a high voltage generator, a ray generator, a cup tray 91 for mounting a cup 01, a rotary driver 92 for driving the cup tray 91 to rotate, and a shielding shell 1; wherein the blood cup tray 91 is rotatably disposed in an irradiation chamber 100 defined by the shield case 1. Since the X-ray tube 93 is located outside the irradiation chamber 100, a radiation passing hole 101 needs to be provided in the shielding case 1, so that during the irradiation treatment of the blood product, the X-ray tube 93 will emit X-rays for irradiation to the irradiation chamber 100 of the shielding case 1 through the radiation passing hole 101, and these X-rays for irradiation entering the irradiation chamber 100 will constitute an X-ray beam for irradiation. Wherein the blood cup 01 forms a container for irradiation in the present embodiment, which is placed in the irradiation cavity 100; while the blood cup tray 91 constitutes, together with the rotary drive 92, the rotary drive in this embodiment for driving the irradiation vessel in rotation about the axis of rotation 10.
In the present embodiment, the specific structure of the shielding shell 1 and the manufacturing method thereof adopt the technical scheme disclosed in the patent document with publication number CN111701104a filed by the applicant; wherein the radiation passing hole 101 is a circular hole.
As shown in fig. 12 and 13, compared with the blood irradiation instrument in the prior art, the technical solution of the present embodiment mainly arranges the beam cross-section shaping opening 20 on the beam travelling path so as to be able to shape the boundary shape of the cross-section of the irradiation X-ray beam by passing through the boundary of the shaping opening 20, and the boundary of the beam cross-section shaping opening 20 is constructed by the edge of the lead plate 2; specifically, as shown in fig. 13, a lead plate 2 provided with a radiation passage hole constituting a beam cross-sectional shape shaping port 20 in the present embodiment is used, which is disposed outside the shield case 1. The lead plate 2 having the beam cross-sectional shape shaping port 20 constitutes a beam cross-sectional shape adjusting mechanism in the present embodiment, which is disposed on a beam traveling path of the X-rays from the X-ray tube 5 to the irradiation container.
As shown in fig. 12 and 13, the radiation emitted from the X-ray tube forms an outgoing beam 3, and after the outgoing beam 3 is shaped by the beam cross-sectional shape shaping opening 20, an irradiation X-ray beam 30 is formed which enters the irradiation chamber 100 through the radiation passage hole 101, that is, a beam 31 to be shielded located on the outer periphery of the irradiation X-ray beam 30 is shielded by the shielding effect of the lead plate 2.
In this embodiment, the beam cross-sectional shape shaping opening 20 is specifically shown in fig. 13, that is, a rectangular structure with a length direction vertically arranged, specifically, the length direction extends along the axial direction of the rotation axis 10, as shown in fig. 3, 12 and 13, so that the cross section 300 of the irradiation X-ray beam 30 that irradiates the blood cup 01 has two side boundary lines 301 and 302 oppositely arranged, as shown in fig. 13, and both the boundary line 301 and the boundary line 302 are arranged along the axial direction of the rotation axis 10, specifically, vertically arranged, and the rotation axis 10 is located within the irradiation range of the irradiation X-ray beam 30.
As shown in fig. 13, in the axial direction of the rotation axis 10, the boundaries of the upper and lower ends of the X-ray beam 30 for irradiation are only required to completely cover the blood product to be irradiated, and other specific requirements are not required, so that the requirement of uniform irradiation can be met, therefore, according to the arrangement of the irradiation container structure such as a blood cup, the lower end boundary line 303 of the cross section 300 is positioned at the lower side of the bottom surface of the effective accommodating cavity of the irradiation container, and as for the upper end boundary line 304, an operator can select the accommodating capacity according to the boundary mark of the upper end of the ray beam arranged on the container, and only the boundary is required to be not exceeded according to the requirement; of course, in order to facilitate the operation of the operator, i.e. the alignment operation is performed according to the upper side edge of the effective housing cavity of the container, for example at the upper side edge of the blood cup; in this embodiment, therefore, the upper end boundary line 304 of the cross section 300 is located on the upper side of the cavity top surface of the effective accommodation cavity of the irradiation container, preferably in the axial direction of the rotation axis 10.
As shown in fig. 12 and 13, on a cross section 0100 of the over-rotation axis 10 of the blood cup 01, the cross section 0100 is arranged parallel to the cross section 300, so that both side boundary lines 301 and 302 of the irradiation X-ray beam 30 after the vertical boundary is shaped are located within the cross section 0100, and are located outside the upper and lower end boundary lines 303 and 304 vertically, namely, in the accommodating cavity of the blood cup 01, as shown in fig. 12, on a transverse plane of which the surface normal direction is arranged along the axial direction of the rotation axis 10, the irradiation area of the irradiation X-ray beam 30 in the accommodating cavity is smaller than the effective accommodating area of the accommodating cavity, wherein the effective accommodating area is the area surrounded by a broken line 010, namely, the inner cavity area of the blood cup 01, and the irradiation area is the area of a central area surrounded by a straight line EF, a straight line GH and the broken line 010; in the case of the arrangement of the irradiation X-ray beam 30 as described above, the applicant found, based on the formulae or experimental test data described in the background art, that if the irradiation area of the irradiation X-ray beam 30 in the accommodating chamber is smaller than the accommodating area of the accommodating chamber, the cumulative amount of irradiation dose of the object to be irradiated after one rotation is better in radial uniformity than in complete coverage.
In order to study the relationship between irradiation uniformity and area ratio, the area ratio is the ratio of the irradiation area of the irradiation X-ray beam in the accommodating cavity of the irradiation container to the accommodating area of the accommodating cavity on the transverse plane which is arranged along the axial direction of the rotation axis 10 in the surface normal direction, specifically, the test is based on the single X-ray beam 30, namely, only a single beam cross-section shaping opening 20 is arranged on the ray path, the rotation axis 10 is positioned on the symmetrical plane of the irradiation X-ray beam 30, two side boundary surfaces of the irradiation X-ray beam 30 are symmetrically arranged about the symmetrical plane of the beam, two side boundary surfaces of the beam are formed by extending the boundary lines 301 and 302 along the ray direction, and the blood cup 01 is a straight cylinder structure which is vertically arranged along the height direction; as shown in fig. 13, specifically, two strip boundaries are symmetrically arranged on the same beam cross-sectional shape shaping opening 20 about a projection axis 200, which is a projection of the rotation axis 10 on the beam cross-sectional shape shaping opening 20, that is, boundaries on two sides of the beam cross-sectional shape shaping opening 20 are symmetrically arranged about the projection axis 200. Specifically, for constructing the container for irradiation with the blood cup 01, the axial direction of the rotation axis 10 is arranged vertically.
The method specifically adopts the following mode to test the radiation dose accumulation amount in the whole rotation process along with the blood cup at different positions in the blood cup, and specifically adopts an ionization chamber and a probe to test, and comprises the following steps:
(1) Adding water bodies such as a blood cup to a full-load state, placing the blood cup in a shielding body of X-ray irradiation equipment, and adjusting an ionization chamber probe to a target test point;
(2) Starting an irradiation program, irradiating unit time, and ensuring that the rotation speeds of the ionization chamber probe and the blood cup are the same, in particular, the ionization chamber probe and the blood cup are kept in a relatively static state, so that the ionization chamber probe rotates in the shielding body along with the blood cup, and when the tube current reaches the normal irradiation maximum current, the dosimeter starts to measure until the irradiation program is finished; recording the absorbed dose of the test point probe;
(3) Completing the test item by item according to the selected test points;
(4) And (5) summarizing the data of all the test points, and calculating the absorbed dose data in the blood cup.
Based on the above steps, as shown in fig. 13, tests are performed based on the beam cross-sectional shape shaping openings 20 of different areas or the placement positions thereof from the X-ray tube 5, so as to construct different area ratios for tests, specifically, test cases under 14 scale conditions as shown in table 1 below.
TABLE 1 area ratios corresponding to different numbered curves
| |
1 | 2 | 3 | 4 | 5 | 6 | 7 |
| △S | 95％ | 90％ | 85％ | 80％ | 75％ | 70％ | 65 |
| Numbering device | |||||||
| 8 | 9 | 10 | 11 | 12 | 13 | 14 | |
| △S | 60％ | 55％ | 50％ | 40％ | 30％ | 20％ | 10％ |
Due to the rotational symmetry, different curves are, as shown in fig. 4, for different area ratios, tested for the cumulative amounts of radiation dose at different points in two directions extending outwards from the rotation axis 10, thereby fitting a cumulative amount curve profile; in the figure, the abscissa indicates the radial direction opposite to the two sides, different from the rotation axis 10, in mm, and the ordinate indicates the cumulative radiation absorbed dose, in Gy; the above is a measurement of one revolution of the blood cup 01 at a constant speed, it being understood that it may be rotated for several revolutions in order to meet the cumulative radiation dose requirement of blood irradiation.
As can be seen from table 1 and fig. 4, the cumulative radiation absorption dose at the outermost side of the blood cup gradually decreases with decreasing area ratio, and the cumulative radiation absorption dose at the center of the blood cup gradually decreases, but the decreasing amplitude is smaller than the cumulative radiation absorption dose at the outermost side. The irradiation absorbed dose uniformity curve is plotted according to fig. 4 as shown in fig. 5, in which the abscissa represents the area ratio Δs and the ordinate represents the uniformity value, and it is understood from the figure that uniformity is always less than 38.5% at full coverage when Δs is less than 100% and greater than zero, indicating that uniformity can be improved by limiting the X-ray beam by the lead sheet, uniformity is about 30% when Δs is 20% to 90%, indicating that uniformity is further improved, and uniformity is further improved to within 20% when Δs is 30% -85%, and uniformity is improved to within 10% when Δs is set at 60-75%, which is an dislike preferable scheme in the present embodiment. In the test, the distance between the irradiation source point and the center of the blood cup is preferably 100-600mm, and the effective irradiation angle of the X-ray is 10-80 DEG, considering the effective irradiation area of the X-ray.
The blood irradiator based on the structure performs irradiation treatment on an object to be irradiated which is accommodated in the irradiation container by utilizing high-energy rays in the working process, and drives the irradiation container to drive the object to be irradiated to rotate around the rotation axis in the irradiation treatment process; wherein, after the ray beam passes the following steps, the irradiation treatment is carried out on the blood, namely the object to be irradiated:
(1) The X-rays are filtered before shaping the beam.
In this step, the aluminum sheet is used for filtering treatment, and the aluminum sheet can be used for clutter elimination or other manners, such as copper sheet.
(2) The ray bundles are subjected to a finishing treatment so that a cross section 300 of the irradiation ray bundle composed of the high-energy rays has two side boundary lines 301, 302 which are arranged oppositely, and the two side boundary lines 301, 302 are each arranged along an axial direction of the rotation axis 10, the rotation axis 10 being located within an irradiation range of the irradiation ray bundle; and a lower end boundary line 303 of the beam boundary defined by both side boundary lines is located below the cavity bottom surface of the effective accommodation cavity of the irradiation container in the axial direction.
Example 2
As an explanation of embodiment 2 of the present invention, only the differences from embodiment 1 described above will be explained, and specifically, the structure and arrangement position of the beam cross-sectional shape adjusting mechanism are specifically limited.
In the present embodiment, as shown in fig. 3, the radiation passing hole 101 has a circular hole structure, as shown in fig. 6 to 11, and the beam cross-sectional shape adjusting mechanism 6 has a sleeve holder 7 fitted in the radiation passing hole 101 shown in fig. 3, and a hole-distributing lead plate 8 fixed to the sleeve holder 7; the hole-distributing lead plate 8 is a circular lead plate provided with a beam cross section shape adjusting hole 80; the beam cross-sectional shape adjustment hole 80 has two elongated boundaries 801, 802 arranged in the axial direction, an upper side connection boundary 803 and a lower side connection boundary 804 for connecting the same side ends of the two elongated boundaries; two elongated borders 801, 802 arranged opposite each other are used for letting the irradiating X-ray beam have two borderlines on both sides. Wherein the beam cross-sectional shape adjustment aperture 80 constitutes a beam cross-sectional shape shaping orifice in the present embodiment.
As shown in fig. 6 to 9, the sleeve holder 7 includes a small-diameter sleeve barrel portion 70 for being fitted in the radiation passage hole 101, and a large-diameter sleeve barrel portion 71 having an inner hole for being fitted in the hole-distribution lead plate 8; a stepped end surface 72 abutting against the side surface of the shielding case is formed at the joint of the two sleeve barrel parts, so that the projection of the hole-distributing lead plate 8 sleeved in the large-diameter sleeve barrel part 71 on the side surface completely covers the ray passing hole 101, and the hole-distributing lead plate 8 is fixed on the inner cavity of the large-diameter sleeve barrel part 71, in particular against the inner shoulder surface 73 by adopting the cooperation of a screw and a through hole 81 arranged on the hole-distributing lead plate 8. Wherein the beam cross-sectional shape adjustment aperture 80 constitutes a beam cross-sectional shape shaping orifice in the present embodiment.
In order to facilitate the fixation of the sleeve bracket 7 on the radiation passing hole 101, a plurality of elastic supporting arms 701 are arranged on the small-diameter sleeve barrel part 70 so as to be clamped on the inner cavity wall of the radiation passing hole 101; specifically, the elastic supporting arm 701 is an elastic claw structure, and forms a fastening structure with a fastening hole provided on the radiation passing hole 101, specifically a detachable fastening structure; as shown in fig. 9, a thinned and softened arm portion 7010 is provided at the fixed end portion of the elastic support arm 701.
In order to improve the fit relationship between the hole-making lead plate 8 and the large-diameter sleeve portion 71, in this embodiment, as shown in fig. 11, the hole-making lead plate 8 is provided with a sleeve collar 83 that is sleeved in the small-diameter sleeve portion 70.
Example 3
As an explanation of embodiment 3 of the present invention, only the differences from embodiment 1 described above will be described below, specifically, the beam cross-sectional shape adjusting mechanism has two or more beam cross-sectional shape shaping ports arranged in sequence along the extending direction of the traveling path of the beam, for sequentially shaping the cross-sectional shapes of the same beam.
As shown in fig. 14, in this embodiment, along the direction of the X-ray tube pointing to the irradiation container, the beam cross-sectional shape adjusting mechanism has more than two beam cross-sectional shape shaping openings 810, 820 arranged in sequence, respectively arranged on two hole-distribution lead plates, and after the X-ray beam adjusted by the upstream side shaping opening 810 is adjusted by the downstream side shaping opening 820, both side boundary lines on the adjusted X-ray beam have inward offset, that is, when the beam is shaped by only one shaping opening at a corresponding position, the included angle between both side surfaces after the adjustment by the upstream side shaping opening 810 is relatively large.
As shown in fig. 15 and 16, the result of imaging the radiation area by using the film is shown, wherein fig. 15 is the film imaging after the shaping treatment of a single shaping opening, and fig. 16 is the film imaging after the shaping treatment of two shaping openings arranged in series, the imaging patterns of the two films can be clamped, the width of the transition area of the imaging boundary of the film with the two beam cross-section shaping openings is smaller than that of the imaging boundary of the single beam cross-section shaping opening, and the width of the transition area is the distance from the imaging stable area to the imaging free area; after the verification of the applicant, the imaging result is better as the number of shaping openings is increased.
In the above embodiment, a cylindrical structure is generally adopted to construct an irradiation container such as a blood cup, which is a preferred scheme, or a structure with a rectangular, square, oval, multi-deformation cross section is adopted, which only needs to be arranged in the normal direction along the axial direction of the rotation axis 10, and the effective irradiation area is smaller than the effective accommodation area; wherein the "effective accommodation area" is configured as an area available for accommodating an object to be irradiated, and the "irradiation area" is configured as an area filled with rays within the effective accommodation area of the irradiation vessel.
Wherein, the boundary lines on two sides are arranged along the axial direction of the rotation axis, the fluctuation amplitude of the boundary lines on two sides in the transverse direction perpendicular to the axial direction is less than 5% of the diameter of the container, and the diameter of the container is the equivalent straight cylinder diameter of the irradiation container; preferably a straight boundary in the axial direction parallel to the axis of rotation.
In addition, in the above embodiment, the irradiation instrument structure is constructed based on an X-ray tube, and the X-ray tube is located outside the irradiation cavity, and a beam cross-sectional shape adjusting mechanism is arranged on the traveling path; the beam cross-section shape adjusting mechanism is provided with a beam cross-section shape adjusting opening defined by a lead plate boundary, the beam cross-section shape adjusting opening is provided with two strip boundaries which are oppositely arranged and axially arranged along the rotation axis, the beam cross-section shape adjusting opening is used for enabling the irradiation beam entering the irradiation cavity to irradiate the region where the rotation axis is located, and the cross section of the irradiation beam is provided with two side boundary lines which are oppositely arranged and axially arranged. For a specific structure, the radiation passing hole can be set to be the same as the shaping hole when the shielding shell is constructed, so that the shaping treatment of the cross-sectional shape of the radiation beam entering the irradiation cavity is realized.
In the above embodiment, the "beam cross-sectional shape adjustment port" is configured as a hole structure arranged on the same lead plate, and may be formed by overlapping a plurality of lead plates having lead plate portions overlapping at the joint.
In addition, the man skilled in the art can modify the structure of the existing irradiation instrument based on the structure of the irradiation instrument after the modification, and the specific modification method comprises the following steps: a beam cross section shape adjusting mechanism is arranged on the travelling path of the irradiation beam of the existing irradiation instrument, so that the cross section of the irradiation X-ray beam irradiating the irradiation container is provided with two side boundary lines which are oppositely arranged and are arranged along the axial direction of a rotation axis 10, and the rotation axis is positioned in the irradiation range of the irradiation X-ray beam; and in the axial direction, the lower end of the beam boundary defined by the boundary lines on the two sides is positioned below the bottom surface of the effective accommodating cavity of the irradiation container; and on a transverse plane arranged in the axial direction in a plane normal to the aforementioned direction, the irradiation area of the irradiation X-ray beam in the accommodation chamber of the container is smaller than the accommodation area of the accommodation chamber. The specific process is as follows:
(1) And a planning step, calculating the structural parameters of the beam cross-section shape adjusting mechanism according to the structural parameters of the existing radiation instrument and the layout positions of the beam cross-section shape adjusting mechanism.
In this step, for example, the beam cross-sectional shape adjustment mechanism and the arrangement position thereof shown in the structure of example 2 are used, and the size of the beam cross-sectional shape adjustment opening needs to be calculated based on the blood cup size parameter and the size parameter of the radiation passing hole, that is, the distance between the X-ray tube and the blood cup 01, that is, the target uniformity parameter.
(2) And processing the beam cross-section shape adjusting mechanism according to the calculated structural parameters of the beam cross-section shape adjusting mechanism.
(3) The beam cross-section shape adjusting mechanism is installed in the existing irradiation instrument.
(4) And testing the uniformity of the irradiation dose accumulation amount of the irradiation instrument in the irradiation container after modification, and evaluating the modification result according to the test result.
For the retrofit method or the aforementioned new apparatus, a position adjusting mechanism may be provided for adjusting the distance between the beam cross-sectional shape adjusting mechanism and the irradiation container such as the X-ray tube or the blood cup, thereby adjusting the distance to adjust the target uniformity according to the test result.
Claims (5)
1. A method for retrofitting an X-ray based irradiation treatment apparatus, the irradiation treatment apparatus comprising a shielding housing for enclosing an irradiation cavity, an X-ray tube positioned outside the irradiation cavity, an irradiation vessel positioned within the irradiation cavity, and a rotational drive for driving the irradiation vessel to rotate about a rotational axis; the shielding shell is provided with a circular ray passing hole, and the X-ray tube emits X-rays for irradiation to the irradiation cavity through the ray passing hole; characterized in that the method comprises the steps of:
a planning step, calculating the structural parameters of the beam cross-section shape adjusting mechanism according to the structural parameters of the existing radiation instrument and the layout positions of the beam cross-section shape adjusting mechanism; the beam cross-sectional shape adjusting mechanism is arranged on a ray traveling path of the X-rays from the X-ray tube to the irradiation container, and is used for enabling cross sections of irradiation X-ray beams irradiating to the irradiation container to have two side boundary lines which are oppositely arranged, wherein the two side boundary lines are arranged along the axial direction of the rotation axis, and the rotation axis is positioned in the irradiation range of the irradiation X-ray beams; and in the axial direction, the lower end of the beam boundary defined by the boundary lines on the two sides is positioned at the lower side of the bottom surface of the effective accommodating cavity of the irradiation container; an irradiation area of the irradiation X-ray beam in the accommodating cavity is smaller than an accommodating area of the accommodating cavity on a transverse plane arranged along the axial direction in a plane normal direction; the beam cross-section shape adjusting mechanism is provided with a beam cross-section shape shaping opening defined by a lead plate boundary, the irradiation X-ray beam adjusted by the beam cross-section shape shaping opening can irradiate the area where the rotation axis is located, and the beam cross section adjusted by the beam cross-section shape shaping opening is provided with two side boundary lines; the ray passing hole is of a circular hole structure, and the ray beam cross section shape shaping opening is a ray beam cross section shape adjusting hole; the ray beam cross section shape adjusting mechanism is provided with a sleeve bracket sleeved in the ray passing hole and a hole-distributing lead plate fixed on the sleeve bracket; the hole-distributing lead plate is a round lead plate provided with the beam cross section shape adjusting holes; the beam cross section shape adjusting hole is provided with two strip boundaries which are arranged along the axial direction, and an upper side connecting boundary and a lower side connecting boundary which are used for connecting the same side end parts of the two strip boundaries; two of the strip boundaries are arranged oppositely for enabling the irradiation X-ray beam to have the two side boundary lines; the sleeve bracket comprises a small-diameter sleeve barrel part sleeved in the ray passing hole, and a large-diameter sleeve barrel part with an inner hole for sleeving the circular lead plate; a step end face which is abutted against the side face of the shielding shell is formed at the joint of the two sleeve barrel parts, so that the projection of the circular lead plate on the side face completely covers the ray passing hole; the beam cross section shape adjusting mechanism is provided with more than two beam cross section shape shaping ports which are sequentially arranged along the extending direction of the travelling path and used for sequentially adjusting the cross section shape of the same beam; and the X-ray beam after being adjusted by the upstream side shaping opening is adjusted by the downstream side shaping opening along the direction that the X-ray tube points to the irradiation container, so that the two side boundary lines on the adjusted X-ray beam have inward offset; a plurality of elastic supporting arms are arranged on the small-diameter sleeve barrel part and used for clamping the small-diameter sleeve barrel part on the inner cavity wall of the ray passing hole; the elastic supporting arm is of an elastic claw structure, is used for forming a clamping structure with a clamping hole arranged on the ray passing hole, and is of a detachable clamping structure; the hole-distributing lead plate is provided with a sleeved convex ring sleeved in the small-diameter sleeved cylinder part;
a processing step of processing the beam cross-section shape adjusting mechanism according to the calculated structural parameters of the beam cross-section shape adjusting mechanism;
a mounting step of mounting the processed beam cross-section shape adjusting mechanism in the existing irradiation instrument;
and a test evaluation step, wherein uniformity of the irradiation dose accumulation amount of the modified irradiation instrument in the irradiation container is tested, and the modification result is evaluated according to the test result.
2. The method according to claim 1, characterized in that:
the ratio of the irradiation area to the receiving area is 0.3 to 0.85.
3. The method according to claim 2, characterized in that:
the ratio of the irradiation area to the receiving area is 0.6 to 0.75.
4. The method according to claim 1, characterized in that:
in the mounting step, a position adjusting mechanism is arranged between the beam cross-section shape adjusting mechanism and the existing irradiation instrument, and the position adjusting mechanism is used for adjusting the distance between the beam cross-section shape adjusting mechanism and the X-ray tube or the irradiation container;
and according to the test result of the test evaluation step, adjusting the distance between the beam cross-section shape mechanism and the X-ray tube or the irradiation container, and adjusting the uniformity of a target positioned at the irradiation container.
5. The method according to any one of claims 1 to 4, wherein:
the rotation axis is positioned on a ray bundle symmetrical surface, two side boundary surfaces of the X-ray bundle for irradiation are symmetrically arranged relative to the ray bundle symmetrical surface, and the two side boundary surfaces are formed by extending the two side boundary lines along the ray direction;
the axial direction is vertically arranged;
the number of the irradiation ray beams is a single ray;
the irradiation container is of a straight cylinder structure which is arranged in a height direction along the axial direction in an extending way;
the both side boundary lines are arranged in the axial direction of the rotation axis such that the amplitude of fluctuation of the both side boundary lines in the lateral direction perpendicular to the axial direction is less than 5% of the container diameter which is the equivalent straight cylinder diameter of the irradiation container.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011546231.4A CN112768107B (en) | 2020-12-23 | 2020-12-23 | Irradiation treatment equipment and irradiation treatment method based on X rays |
| PCT/CN2021/140977 WO2022135544A1 (en) | 2020-12-23 | 2021-12-23 | X-ray-based irradiation treatment equipment and irradiation treatment method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011546231.4A CN112768107B (en) | 2020-12-23 | 2020-12-23 | Irradiation treatment equipment and irradiation treatment method based on X rays |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112768107A CN112768107A (en) | 2021-05-07 |
| CN112768107B true CN112768107B (en) | 2023-07-11 |
Family
ID=75694031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011546231.4A Active CN112768107B (en) | 2020-12-23 | 2020-12-23 | Irradiation treatment equipment and irradiation treatment method based on X rays |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN112768107B (en) |
| WO (1) | WO2022135544A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112768107B (en) * | 2020-12-23 | 2023-07-11 | 珠海丽珠试剂股份有限公司 | Irradiation treatment equipment and irradiation treatment method based on X rays |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6504898B1 (en) * | 2000-04-17 | 2003-01-07 | Mds (Canada) Inc. | Product irradiator for optimizing dose uniformity in products |
| CN200991450Y (en) * | 2006-12-28 | 2007-12-19 | 中国核动力研究设计院 | Blood radiometer capable of regulating central dose rate |
| CN111701104A (en) * | 2020-04-30 | 2020-09-25 | 珠海丽珠试剂股份有限公司 | Shielding shell of blood irradiator and manufacturing method of shielding shell |
| CN112768107B (en) * | 2020-12-23 | 2023-07-11 | 珠海丽珠试剂股份有限公司 | Irradiation treatment equipment and irradiation treatment method based on X rays |
-
2020
- 2020-12-23 CN CN202011546231.4A patent/CN112768107B/en active Active
-
2021
- 2021-12-23 WO PCT/CN2021/140977 patent/WO2022135544A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022135544A1 (en) | 2022-06-30 |
| CN112768107A (en) | 2021-05-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2634775B1 (en) | Linear accelerators | |
| JP3675816B2 (en) | Dynamic beam smoothing device for radiation therapy | |
| US8321179B2 (en) | Multiple axes scanning system and method for measuring radiation from a radiation source | |
| US4375695A (en) | Device for determining the density distribution in an object | |
| CN112768107B (en) | Irradiation treatment equipment and irradiation treatment method based on X rays | |
| EP2727119B1 (en) | X-ray beam transmission profile shaper | |
| GB1478123A (en) | Tomography | |
| US20140140471A1 (en) | Computerized tomography (ct) imaging system with multi-slit rotatable collimator | |
| CN216749332U (en) | Blood irradiator | |
| WO2020038224A1 (en) | Source carrier, radiotherapy equipment, and control driving method therefor | |
| Atherton et al. | CT doses in cylindrical phantoms | |
| JP4436343B2 (en) | Multi-leaf collimator and radiotherapy apparatus assembly method | |
| Matscheko et al. | Compton spectroscopy in the diagnostic x-ray energy range: I. Spectrometer design | |
| Skarsgard et al. | Spectral flux density of scattered and primary radiation generated at 250 kv | |
| EP3755431B1 (en) | Water tank apparatus | |
| US7388207B1 (en) | Skew slit collimator and method of use thereof | |
| GB1589469A (en) | Radiography | |
| JP5680510B2 (en) | Charged particle beam irradiation equipment | |
| US4371976A (en) | X-Ray apparatus for determining the absorption distribution in a flat examination zone | |
| Webber et al. | A clinical system for the in vivo measurement of lung density | |
| JP2007319496A (en) | Control device for radiotherapy system and radiation irradiation method | |
| CN219089326U (en) | Radiation therapy system | |
| US20240091561A1 (en) | Radiation therapy system | |
| Krithivas et al. | Arc therapy dose perturbation due to the center bar in a clinic 4/100 couch assembly | |
| JP2022152675A (en) | Phantom for detector calibration, radiation measuring system, and container kit |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |