CN112755837A

CN112755837A - High-speed tissue mashing and homogenizing method for bio-pharmaceuticals

Info

Publication number: CN112755837A
Application number: CN202011491054.4A
Authority: CN
Inventors: 杜雪琴
Original assignee: Guangzhou Hangdi Technology Co ltd
Current assignee: Guangzhou Hangdi Technology Co ltd
Priority date: 2021-02-19
Filing date: 2021-02-19
Publication date: 2021-05-07

Abstract

The invention relates to the technical field of biological pharmacy, and discloses a high-speed tissue mashing and homogenizing method for biological pharmacy. The invention adds the stopping rotation mechanism, so that after the material to be processed is stirred by the tissue mashing and homogenizing machine, the motor needs to be stopped and cooled, the stirring rod drives the driving wheel to rapidly decelerate, the driven disc continuously rotates at a speed higher than the rotating speed of the driving wheel under the action of inertia, and simultaneously, because the rotating speed difference between the driven disc and the stirring rod is larger, the elastic rope can be wound around the middle part of the stirring rod, so that after the rotating speed of the driven disc is reduced, the elastic rope is released, the driven disc rotates reversely again, and after the motor stops rotating, the equipment can rotate for many times under the conditions of inertia and elastic rope recovery to uniformly stir the paste.

Description

High-speed tissue mashing and homogenizing method for bio-pharmaceuticals

Technical Field

The invention relates to the technical field of biological pharmacy, in particular to a method for mashing and homogenizing high-speed tissues for biological pharmacy.

Background

A homogenizer is a machine for breaking up animal and plant tissues and grinding them into a uniform paste, and is widely used in the homogenization of animal tissues, biological samples, food, drugs, cosmetics, agricultural products and other samples, and the homogenizer can be roughly divided into: the tissue mashing and homogenizing machine comprises three types, namely a tissue mashing and homogenizing machine, an adjustable high-speed disperser (a homogenizing machine) and a solid sample crusher, wherein the tissue mashing and homogenizing machine is widely applied to the fields of scientific research, medical treatment, chemical industry, pharmacy, food industry and the like.

The stirring and mixing of liquid medicines and the mashing of a microbial culture medium in the process of manufacturing the biological medicines of a tissue mashing and homogenizing machine for the biological pharmacy are carried out under the aseptic operation, the tools are strictly disinfected to avoid the infection of infectious microbes, and when the biological pharmacy is carried out, because a machine is not easy to idle, a small amount of liquid needs to be added, the viscous resistance of processed paste is reduced, the burden of a mashing blade in the working process is reduced, and when the tissue mashing and homogenizing machine works normally, because the high rotating speed is needed for mashing materials to be processed, a motor can be burnt out under the condition of continuous use, therefore, in each process of carrying out the biological pharmacy, the tissue mashing and homogenizing machine can only work for three minutes, and then the cooling needs to be stopped for five minutes, so that the uniformity degree of the paste cannot be guaranteed after the primary mashing processing of the materials to be processed, and because the width of the mashing blade is thinner, the efficiency of uniformly stirring the processed paste is lower every time, and the processing efficiency of machinery is influenced.

Disclosure of Invention

The invention provides a high-speed tissue mashing and homogenizing machine for bio-pharmaceuticals and a processing method thereof, aiming at the defects of the prior tissue mashing and homogenizing machine in the use process in the background technology.

The invention provides the following technical scheme: a high-speed tissue mashing and homogenizing machine for bio-pharmaceuticals comprises a machine base, wherein a controller is fixedly connected to one side of the upper surface of the machine base, a supporting rod is fixedly connected to one end of the other side of the upper surface of the machine base, an adjusting frame is sleeved on the outer surface of the supporting rod through bolt activity, a motor is fixedly connected to the other end of the adjusting frame, a stirring rod is movably clamped at the rotating end of the motor, a cup body is movably connected to the middle of the stirring rod, a driven disc located in the middle of an inner cavity of the cup body is movably connected to one end of the stirring rod, a driving wheel located in the inner cavity of the driven disc is fixedly connected to one end of the stirring rod, a clamping block is movably connected to the side face of the driving wheel, one side of the clamping block is movably connected with the inner wall of the driven disc through a spring, and the telescopic rod penetrates through the driven disc and extends into the inner cavity of the mashing blade, and one end of the middle part of the stirring rod is movably connected with the inner cavity of the driven disc through an elastic rope

Preferably, the air cavity is opened to the one end of telescopic link inner chamber, the one end activity of air cavity has cup jointed the pressure gas pole, and the other end of pressure gas pole and smash the inner chamber fixed connection of piece to pieces, the middle part swing joint of telescopic link has the stirring leaf, and the other end and the air cavity intercommunication of stirring leaf

Preferably, the number of the extending blocks, the clamping blocks and the mashing blades on the side surface of the driving wheel is four

Preferably, one end of the stirring blade is positioned on the bottom surface of the mashing blade, and the distances between the stirring blade and the outer surface of the driven disc on each mashing blade are different

Preferably, one side of the fixture block is clamped with one side of the side extension block of the driving wheel, and the inclination angles of the other side of the fixture block and the other side of the side extension block of the driving wheel are the same

Preferably, the number of the elastic ropes is four, and the elastic ropes are arranged around the stirring rod at equal angles.

Preferably, the middle part of the stirring rod is cross-shaped, and the upper surface of the middle transverse plate of the stirring rod is contacted with the lower surface of the middle transverse plate of the driven plate.

A high-speed tissue mashing and homogenizing machine for bio-pharmaceuticals and a processing method thereof comprise the following operation steps:

s1, placing the material to be processed into the cup body, covering the cup body with a cover with a stirring rod, and then installing the cup body on the upper surface of the base to enable the upper end of the stirring rod to be clamped with the rotating end of the motor;

s2, starting the motor through the controller, and controlling the rotating speed of the rotating end of the motor to enable the stirring rod to drive the driven disc to synchronously rotate through clamping connection, so that the material to be processed in the cup body is stirred up and primarily stirred uniformly through the rotation of the mashing blade;

s3, after the motor works for three minutes, the motor automatically stops working, the rotating speed of the stirring rod is reduced, and the driven disc continuously rotates under the action of inertia, so that after the motor stops, the driven disc drives the mashing blade to continuously rotate at a certain rotating speed, and the clamping block is separated from one side of the driving wheel in a clamping manner;

s4, under the action of centrifugal force, the fixture block separated from the driving wheel drives the telescopic rod compression spring to move outwards, the air in the cavity of the air cavity is compressed through the air compression rod, the air is moved towards one end of the stirring blade, and the stirring blade is pushed out downwards, so that when the driven disc drives the mashing blade to rotate continuously, the stirring blade extends out to stir the stirred material;

s5, when the driven disc rotates under the action of inertia, the elastic rope is wound around the stirring rod due to the fact that the rotating speed difference between the driven disc and the stirring rod is large, and after the rotating speed of the driven disc is reduced, the elastic rope is recovered, so that the driven disc drives the mashing blade to rotate reversely, and materials which are stirred uniformly again.

The invention has the following beneficial effects:

1. the invention adds the stopping rotation mechanism, so that after the material to be processed is stirred by the tissue mashing and homogenizing machine, the motor needs to be stopped and cooled, the stirring rod drives the driving wheel to rapidly decelerate, the driven disc continuously rotates at a speed higher than the rotating speed of the driving wheel under the action of inertia, and simultaneously, because the rotating speed difference between the driven disc and the stirring rod is larger, the elastic rope can be wound around the middle part of the stirring rod, so that after the rotating speed of the driven disc is reduced, the elastic rope is released, the driven disc rotates reversely again, and after the motor stops rotating, the equipment can rotate for many times under the conditions of inertia and elastic rope recovery to uniformly stir the paste.

2. According to the invention, the auxiliary stirring mechanism is additionally arranged, so that when the stopping and rotating mechanism is started, the spring is compressed under the action of centrifugal force, the telescopic rod moves towards the inner cavity of the mashing blade under the action of centrifugal force, the air cavity is compressed through the air compressing rod, so that air moves, and the stirring blades are pushed downwards, so that the stirring blades can be automatically stretched out when the equipment is stopped and rotated, the stirring efficiency of the equipment is improved, and the auxiliary stirring mechanism can fully and uniformly stir paste in the cup body by setting different distances between the stirring blades and the center of the cup body.

Drawings

FIG. 1 is a perspective view of the present invention;

FIG. 2 is a schematic view of a driven disk of the present invention;

FIG. 3 is a schematic view of a structurally assisted stirring mechanism of the present invention;

FIG. 4 is an enlarged view of the point A in FIG. 1;

FIG. 5 is an enlarged view of the point B in FIG. 1.

In the figure: 1. a machine base; 2. a controller; 3. a support bar; 4. an adjusting bracket; 5. an electric motor; 6. a stirring rod; 7. a cup body; 8. a driven plate; 9. a driving wheel; 10. a clamping block; 11. a telescopic rod; 12. a spring; 13. a mashing blade; 14. stirring blades; 15. a pneumatic rod; 16. an air cavity; 17. an elastic rope.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Referring to fig. 1-5, a high-speed tissue mashing and homogenizing machine for bio-pharmaceuticals comprises a machine base 1, a controller 2 is fixedly connected to one side of the upper surface of the machine base 1, a support rod 3 is fixedly connected to one end of the other side of the upper surface of the machine base 1, an adjusting frame 4 is movably sleeved on the outer surface of the support rod 3 through a bolt, a motor 5 is fixedly connected to the other end of the adjusting frame 4, a stirring rod 6 is movably clamped at the rotating end of the motor 5, a cup body 7 is movably connected to the middle part of the stirring rod 6, a driven disc 8 positioned in the middle part of the inner cavity of the cup body 7 is movably connected to one end of the stirring rod 6, a driving wheel 9 positioned in the inner cavity of the driven disc 8 is fixedly connected to one end of the stirring rod 6, a clamping block 10 is movably connected to the side surface of the driving wheel 9, one side, outer fixed surface that driven plate 8 lower extreme is connected with smashes blade 13, and telescopic link 11 runs through driven plate 8 and extends to in the inner chamber of smashing blade 13,

stretch cord

17 and 8 inner chamber swing joint of driven plate are passed through to the one end at stirring rod 6 middle part, set up the front end through with stirring rod 6 into the form of separation, make when motor 5 owing to need shut down the cooling, make stirring rod 6 stop rotatory back, because driven plate 8 still rotates with faster rotational speed, make action wheel 9 and fixture block 10 separate, and after the separation driven plate 8 rotates with relatively great rotational speed difference respectively with stirring rod 6, make stretch cord 17 twine at the middle part of stirring rod 6, make when 8 rotational speed reductions of driven plate, stretch cord 17 just automatic recovery, make driven plate 8 drive blade 13 reversal once more, stir once more to the material of accomplishing the processing of smashing.

Wherein, air cavity 16 has been seted up to the one end of telescopic link 11 inner chamber, air cavity 16's one end activity cup joints air pressing rod 15, and air pressing rod 15's the other end and the inner chamber fixed connection who smashes blade 13, the middle part swing joint of telescopic link 11 has stirring leaf 14, and stirring leaf 14's the other end and air cavity 16 intercommunication, make after motor 5 stall, driven plate 8 rotates with great rotational speed, make fixture block 10 and action wheel 9 separate, and fixture block 10 compresses spring 12 under the effect of centrifugal force, and drive telescopic link 11 to one side movement, thereby make air pressing rod 15 compress the gas in telescopic link 11 one end air cavity 16, make gas move to stirring leaf 14's one end, make stirring leaf 14 ejecting downwards, make after motor 5 shuts down, make the stirring efficiency of refiner better.

Wherein, the extension piece and fixture block 10 of action wheel 9 side and the quantity of triturating blade 13 are four for when the refiner normally works, treat the stirring of processing material and stir the efficiency better, and make and correspond a fixture block 10 and action wheel 9 side extension piece through every triturating blade 13, make when carrying out the supplementary stirring, the effect of stirring of refiner is better.

Wherein, the one end of stirring leaf 14 is located the bottom surface of smashing blade 13, and the distance that stirring leaf 14 and driven plate 8 surface are all inequality on every piece of smashing blade 13 for when equipment is in the supplementary stirring state, after every stirring leaf 14 stretches out, every stirring leaf 14's stirring position is different, makes the less stirring dead angle of cup 7 inner chamber of ability furthest, has ensured the even of the material of accomplishing the processing.

Wherein, one side of the fixture block 10 is clamped with one side of the side extension block of the driving wheel 9, the inclination angle of the other side of the fixture block 10 is the same as that of the other side of the side extension block of the driving wheel 9, after the motor 5 stops rotating, the driven disc 8 drives the fixture block 10 to rotate at a speed higher than the rotating speed of the driving wheel 9 under the action of inertia, the fixture block 10 is automatically separated from the extension block on the side surface of the driving wheel 9 through the inclined plane with one side inclined, and the small clamping grooves are arranged for clamping, and because the centrifugal force is one of the inertia forces, after the rotating speed of the driven disc 8 is reduced, the spring 12 automatically resets under the action of centrifugal force, so that the fixture 10 is not clamped with the side extension block of the driving wheel 9, when the driven disc 8 rotates reversely through the elastic rope 17, the situation that the driven disc 8 cannot drive the mashing blade 13 to rotate reversely due to the clamping of the clamping block 10 and the driving wheel 9 cannot occur.

Wherein, the quantity of stretch cord 17 is four, and encircle that stirring rod 6 is the equiangular arrangement, through setting up the quantity of stretch cord 17 into four, make when driven plate 8 rotates in order to be greater than 6 rotational speeds of stirring rod, can evenly twine at stirring rod 6 middle part through stretch cord 17, make driven plate 8 can reverse fast after the rotational speed descends, and can pass through stretch cord 17 reversal, make fixture block 10 and the 9 side friction of action wheel, make the rotational speed of stirring rod 6 reduce fast, reduced stirring rod 6 because inertia lasts the rotation, make 5 inner chambers of motor produce the electric energy, the condition that causes the loss to motor 5 life takes place, make the rotational speed of driven plate 8 when the reversal improve, and avoided because fixture block 10 loses centrifugal force, the condition that leads to fixture block 10 and action wheel 9 block takes place.

Wherein, the middle part of stirring rod 6 is the cross, and the upper surface of 6 middle parts of stirring rod diaphragm and the lower surface contact of the middle part diaphragm of driven plate 8 through stirring

rod

6 and 8 contacts of driven plate for driven plate 8 can rotate with the rotational speed that is greater than stirring rod 6, has ensured the shut down stirring ability of equipment, and has reduced driven plate 8 produced frictional force when rotating under inertial action.

s1, placing the material to be processed into the cup body 7, covering the cup body with a cover with the stirring rod 6, and then installing the cup body 7 on the upper surface of the machine base 1 to enable the upper end of the stirring rod 6 to be clamped with the rotating end of the motor 5;

s2, starting the motor 5 through the controller 2, and controlling the rotating speed of the rotating end of the motor 5 to enable the stirring rod 6 to drive the driven disc 8 to synchronously rotate through clamping connection, so that the material to be processed in the cup body 7 is smashed and primarily stirred uniformly through the rotation of the smashing blade 13;

s3, after the motor 5 works for three minutes, the motor 5 automatically stops working, the rotating speed of the stirring rod 6 is reduced, and the driven disc 8 continuously rotates under the action of inertia, so that after the motor 5 stops, the driven disc 8 drives the mashing blade 13 to continuously rotate at a certain rotating speed, and meanwhile, the clamping block 10 is separated from one side, clamped with the driving wheel 9, of the clamping block;

s4, under the action of centrifugal force, the fixture block 10 separated from the driving wheel 9 drives the telescopic rod 11 to compress the spring 12 to move outwards, the air in the inner cavity of the air cavity 16 is compressed through the air compression rod 15, the air is enabled to move towards one end of the stirring blade 14, the stirring blade 14 is pushed out downwards, and when the driven disc 8 drives the mashing blade 13 to rotate continuously, the stirring blade 14 extends out to stir the stirred materials;

s5, the driven disc 8 rotates under the action of inertia, and at the same time, because the difference between the rotating speeds of the driven disc 8 and the stirring rod 6 is large, the elastic rope 17 is wound around the stirring rod 6, and after the rotating speed of the driven disc 8 is reduced, the elastic rope 17 is recovered, so that the driven disc 8 drives the mashing blade 13 to rotate reversely, and the materials which are completely mashed are stirred uniformly again.

It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. The utility model provides a high-speed tissue triturating homogenate method for bio-pharmaceuticals, includes frame (1), one side fixedly connected with controller (2) of frame (1) upper surface, one end fixedly connected with bracing piece (3) of frame (1) upper surface opposite side, the surface of bracing piece (3) has cup jointed alignment jig (4) through the bolt activity, other end fixedly connected with motor (5) of alignment jig (4), its characterized in that: the utility model discloses a mashing machine, including motor (5), rotation end activity joint have stirring rod (6), the middle part swing joint of stirring rod (6) has cup (7), the one end swing joint of stirring rod (6) has driven plate (8) that is located cup (7) inner chamber middle part, the one end fixedly connected with action wheel (9) that is located driven plate (8) inner chamber of stirring rod (6), the side swing joint of action wheel (9) has fixture block (10), the inner wall swing joint of spring (12) and driven plate (8) is passed through to one side of fixture block (10), one side fixedly connected with of fixture block (10) is located telescopic link (11) at spring (12) middle part, outer fixed surface of driven plate (8) lower extreme is connected with and smashes blade (13), and telescopic link (11) run through driven plate (8) and extend to smash in the inner chamber of blade (13), one end of the middle part of the stirring rod (6) is movably connected with the inner cavity of the driven disc (8) through an elastic rope (17);

the mashing and homogenizing method comprises the following operation steps:

s1, placing the material to be processed into the cup body (7), covering a cover with the stirring rod (6), and then installing the cup body (7) on the upper surface of the machine base (1) to enable the upper end of the stirring rod (6) to be clamped with the rotating end of the motor (5);

s2, starting the motor (5) through the controller (2), controlling the rotating speed of the rotating end of the motor (5), enabling the stirring rod (6) to drive the driven disc (8) to synchronously rotate through clamping, and enabling the material to be processed in the cup body (7) to be smashed and preliminarily and uniformly stirred through rotation of the smashing blade (13);

s3, after the motor (5) works for three minutes, the motor (5) automatically stops working, the rotating speed of the stirring rod (6) is reduced, and after the motor (5) stops due to the fact that the driven disc (8) continuously rotates under the action of inertia, the driven disc (8) drives the mashing blade (13) to continuously rotate at a certain rotating speed, and meanwhile the clamping block (10) is separated from one side, clamped with the driving wheel (9);

s4, under the action of centrifugal force, a clamping block (10) separated from a driving wheel (9) drives a telescopic rod (11) to compress a spring (12) to move outwards, and gas in an inner cavity of an air cavity (16) is compressed through a gas pressing rod (15), so that the gas moves towards one end of a stirring blade (14), and the stirring blade (14) is ejected downwards, and when a driven disc (8) drives a mashing blade (13) to rotate continuously, the stirring blade (14) extends out to uniformly stir the stirred materials;

s5, the driven disc (8) rotates under the action of inertia, and meanwhile, the elastic rope (17) is wound around the stirring rod (6) due to the fact that the rotating speed difference between the driven disc (8) and the stirring rod (6) is large, and after the rotating speed of the driven disc (8) is reduced, the elastic rope (17) is recovered, so that the driven disc (8) drives the mashing blade (13) to rotate reversely, and materials which are stirred uniformly are stirred again.

2. The method of claim 1 for mashing and homogenizing high-speed tissue for biopharmaceuticals, wherein the method comprises the steps of: air cavity (16) have been seted up to the one end of telescopic link (11) inner chamber, air cavity (16)'s one end activity cover has connected air pressing rod (15), and air pressing rod's (15) the other end and triturating blade (13) inner chamber fixed connection, the middle part swing joint of telescopic link (11) has stirring leaf (14), and the other end and air cavity (16) intercommunication of stirring leaf (14).

3. The method of claim 2 for mashing and homogenizing high-speed tissue for biopharmaceuticals, wherein the method comprises the steps of: the number of the extension blocks and the fixture blocks (10) on the side surface of the driving wheel (9) and the number of the mashing blades (13) are four.

4. The method of claim 2 for mashing and homogenizing high-speed tissue for biopharmaceuticals, wherein the method comprises the steps of: one end of the stirring blade (14) is positioned on the bottom surface of the mashing blade (13), and the distances between the stirring blade (14) on each mashing blade (13) and the outer surface of the driven disc (8) are different.

5. The method of claim 1 for mashing and homogenizing high-speed tissue for biopharmaceuticals, wherein the method comprises the steps of: one side of the fixture block (10) is clamped with one side of the side extension block of the driving wheel (9), and the inclination angle of the other side of the fixture block (10) is the same as that of the other side of the side extension block of the driving wheel (9).

6. The method of claim 1 for mashing and homogenizing high-speed tissue for biopharmaceuticals, wherein the method comprises the steps of: the number of the elastic ropes (17) is four, and the elastic ropes are arranged around the stirring rod (6) at equal angles.

7. The method of claim 1 for mashing and homogenizing high-speed tissue for biopharmaceuticals, wherein the method comprises the steps of: the middle part of stirring rod (6) is the cross, and the upper surface of stirring rod (6) middle part diaphragm contacts with the lower surface of the middle part diaphragm of driven plate (8).