CN112755588A - Extraction centrifugal mixing system based on bio-pharmaceuticals and centrifugal method thereof - Google Patents
Extraction centrifugal mixing system based on bio-pharmaceuticals and centrifugal method thereof Download PDFInfo
- Publication number
- CN112755588A CN112755588A CN202110042228.7A CN202110042228A CN112755588A CN 112755588 A CN112755588 A CN 112755588A CN 202110042228 A CN202110042228 A CN 202110042228A CN 112755588 A CN112755588 A CN 112755588A
- Authority
- CN
- China
- Prior art keywords
- liquid
- centrifugal cylinder
- centrifugal
- heavy
- light
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960000074 biopharmaceutical Drugs 0.000 title claims abstract description 20
- 238000000605 extraction Methods 0.000 title claims abstract description 19
- 238000002156 mixing Methods 0.000 title claims abstract description 18
- 238000000034 method Methods 0.000 title claims abstract description 12
- 239000007788 liquid Substances 0.000 claims abstract description 250
- 238000000926 separation method Methods 0.000 claims abstract description 87
- 239000003814 drug Substances 0.000 claims abstract description 50
- 239000007791 liquid phase Substances 0.000 claims abstract description 22
- 238000005119 centrifugation Methods 0.000 claims abstract description 16
- 238000003756 stirring Methods 0.000 claims abstract description 6
- 239000007790 solid phase Substances 0.000 claims description 31
- 239000012535 impurity Substances 0.000 claims description 24
- 241000883990 Flabellum Species 0.000 claims description 8
- 238000007599 discharging Methods 0.000 claims description 7
- 238000011010 flushing procedure Methods 0.000 claims description 7
- 238000005452 bending Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000002351 wastewater Substances 0.000 claims description 5
- 238000005192 partition Methods 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
- 230000009471 action Effects 0.000 claims description 3
- 230000008878 coupling Effects 0.000 claims description 3
- 238000010168 coupling process Methods 0.000 claims description 3
- 238000005859 coupling reaction Methods 0.000 claims description 3
- 238000003466 welding Methods 0.000 claims description 2
- 230000008569 process Effects 0.000 abstract description 5
- 230000000630 rising effect Effects 0.000 abstract description 3
- 239000012071 phase Substances 0.000 description 8
- 230000000903 blocking effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 239000008400 supply water Substances 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/08—Cleaning containers, e.g. tanks
- B08B9/093—Cleaning containers, e.g. tanks by the force of jets or sprays
- B08B9/0933—Removing sludge or the like from tank bottoms
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Centrifugal Separators (AREA)
Abstract
The invention discloses an extraction centrifugal mixing system based on bio-pharmaceuticals and a centrifugation method thereof, relating to the field of bio-pharmaceuticals equipment and comprising a centrifugal cylinder, wherein the bottom of the centrifugal cylinder is provided with a liquid inlet interface, and the top of the centrifugal cylinder is provided with a separation box, thus having the advantages that: the liquid medicine separating device is characterized in that a motor drives a rotating shaft, so that a first turbine fan blade and a second turbine fan blade at the bottom of the rotating shaft stir liquid medicine, the liquid medicine rotates at a high speed, the liquid medicine is separated into a heavy liquid phase and a light liquid phase under centrifugal force, the heavy liquid phase is gathered at the outer edge of the inner part of a centrifugal cylinder, the light liquid phase is gathered at the center of the centrifugal cylinder, the heavy liquid phase is led into a heavy liquid separating chamber, the light liquid phase is led into a light liquid separating chamber, mixed liquid between the heavy liquid phase and the light liquid phase is led into a mixed liquid separating chamber in the rising process of the liquid medicine, the mixed liquid in the mixed liquid separating chamber flows back to the bottom of the centrifugal cylinder through a return pipe, and then re-separation is carried.
Description
Technical Field
The invention relates to the field of biological pharmaceutical equipment, in particular to an extraction centrifugal mixing system based on biological pharmacy and a centrifugal method thereof.
Background
In the biopharmaceutical industry, a centrifugal extractor can be used for extracting a plurality of medical intermediates and raw material medicaments. When the traditional tubular centrifuge is used, feed liquid is led into a mixing area, two phases are rapidly mixed and dispersed through a turbine disc or an impeller, two-phase solution is subjected to sufficient mass transfer, the mixed mass transfer process is completed, the mixed feed liquid rotates at a high speed under the action of the vortex disc, the two phases are separated, the clarified two-phase liquid finally enters a collecting chamber through respective weir plates and is respectively led out of the centrifuge through leading pipes, and the two-phase separation process is completed.
In the use process of the traditional tubular centrifuge, two-phase liquid is directly shunted to respective collecting chambers, and residual mixed liquid between the two phases is distributed to the collecting chambers, so that the separation precision is reduced; some solid phase impurity deposits in the centrifuge tube bottom in the tubular centrifuge use, and it is comparatively troublesome to the clearance of these solid phase impurity.
Disclosure of Invention
The invention aims to provide an extraction centrifugal mixing system based on bio-pharmaceuticals and a centrifugal method thereof, so as to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme: the utility model provides an extraction centrifugation hybrid system based on bio-pharmaceuticals is used, includes the centrifuge bowl, the welding of the middle part outer wall of centrifuge bowl has the support grillage, and the lower surface of support grillage is equipped with many spinal branchs post, the bottom of centrifuge bowl is equipped with the feed liquor interface, and the top of centrifuge bowl is equipped with the separator box.
Preferably, the lower joint of the liquid inlet interface is connected with a three-way valve, and the lower port of the three-way valve is connected with a first liquid pump.
Preferably, the top of separator box is fixed with the motor through the bolt, and the output shaft of motor runs through to inside the separator box perpendicularly downwards, and the output shaft end of motor has the pivot that extends to the inside of centrifuge bowl through the coupling joint, and the bottom of pivot is equipped with first turbine flabellum and second turbine flabellum.
Preferably, the separator box is separated from bottom to top by the baffle in proper order and is had heavy liquid separation room, mixed liquid separation room and light liquid separation room, and the downward bending in baffle middle part between heavy liquid separation room and the mixed liquid separation room forms and has first honeycomb duct, and the downward bending in baffle middle part between mixed liquid separation room and the light liquid separation room forms and has the second honeycomb duct.
Preferably, one side of the heavy liquid separation chamber is provided with a heavy liquid discharge port communicated with the heavy liquid separation chamber, one side of the mixed liquid separation chamber is provided with a mixed liquid discharge port communicated with the mixed liquid separation chamber, one side of the light liquid separation chamber is provided with a light liquid discharge port communicated with the light liquid separation chamber, and the outer port of the mixed liquid discharge port is connected with the side joint of the three-way valve through a return pipe.
Preferably, the lower part of the inner wall of the centrifugal cylinder is welded with a solid-phase baffle which is a conical ring plate body with a concave middle part.
Preferably, the middle part of the centrifugal cylinder is provided with a liquid separation disc set, the liquid separation disc set is composed of a plurality of liquid separation discs which are uniformly arranged along the vertical direction, the liquid separation discs are conical ring plate bodies with convex middle parts, and the middle parts of the liquid separation discs are provided with a plurality of liquid separation holes.
Preferably, the liquid separating discs are welded and fixed by the connecting rods, and the liquid separating discs and the inner wall of the centrifugal cylinder are welded and fixed by the supporting rod pieces.
Preferably, two sides of the bottom of the centrifugal cylinder are respectively provided with a flushing interface and a drainage interface which are symmetrical, an outer port of the flushing interface is connected with a second liquid pump, and an outer port of the drainage interface is connected with a drainage valve.
A centrifugation method for an extraction centrifugation mixing system for biopharmaceuticals as described above, comprising the steps of:
the method comprises the following steps: the first liquid pump is connected with a liquid medicine raw material input pipe to enable liquid medicine to enter the centrifugal cylinder along a liquid inlet interface at the bottom of the centrifugal cylinder, a motor drives a rotating shaft to enable a first turbine fan blade and a second turbine fan blade at the bottom of the rotating shaft to stir the liquid medicine and enable the liquid medicine to rotate at a high speed, the liquid medicine is separated into a heavy liquid phase and a light liquid phase under centrifugal force, the heavy liquid phase is gathered at the outer edge of the interior of the centrifugal cylinder, the light liquid phase is gathered at the center of the centrifugal cylinder, the precision of the heavy liquid closer to the outer edge of the interior of the centrifugal cylinder is purer, the precision of the light liquid closer to the center of the centrifugal cylinder is purer under centrifugal force, when the liquid medicine rises, the heavy liquid closer to the outer edge of the interior of the centrifugal cylinder enters a heavy liquid separation chamber under the guide of a first guide pipe and is discharged and separated through a heavy liquid discharge interface, and the light liquid closer to the center of the centrifugal, the mixed liquid between the heavy liquid and the light liquid enters the mixed liquid separating chamber under the guidance of the first guide pipe and the second guide pipe, and flows back to the three-way valve through a return pipe connected with the mixed liquid discharging interface for re-separation;
step two: when the liquid medicine in the centrifugal cylinder rises and passes through the liquid separation disc set, heavy liquid is guided to the outer edge of the interior of the centrifugal cylinder under the guidance of the plurality of liquid separation discs, light liquid is guided to the middle of the centrifugal cylinder, and the efficiency of separating the liquid medicine into light liquid and heavy liquid is improved;
step three: solid-phase impurity in the liquid medicine deposits in the bottom outer fringe of centrifuge bowl under centrifugal force, when needs are cleared up these solid-phase impurity, supplies the clear water through controlling the second liquid pump toward the bath kneck, washes the solid-phase impurity of centrifuge bowl bottom, opens the drain valve after, makes the waste water that carries solid-phase impurity discharge along the drainage interface.
The invention has the technical effects and advantages that:
1. the liquid medicine separation device is characterized in that a motor drives a rotating shaft, so that a first turbine fan blade and a second turbine fan blade at the bottom of the rotating shaft stir liquid medicine, the liquid medicine rotates at a high speed, the liquid medicine is separated into a heavy liquid phase and a light liquid phase under centrifugal force, the heavy liquid phase is gathered at the outer edge of the inner part of a centrifugal cylinder, the light liquid phase is gathered at the center of the centrifugal cylinder, the heavy liquid phase is led into a heavy liquid separation chamber, the light liquid phase is led into a light liquid separation chamber, a mixed liquid between the heavy liquid phase and the light liquid phase is led into a mixed liquid separation chamber in the rising process of the liquid medicine, the mixed liquid in the mixed liquid separation chamber flows back to the bottom of the centrifugal cylinder through a return pipe, re-separation is carried out;
2. when the liquid medicine in the centrifugal cylinder rises and passes through the liquid separation disc set, heavy liquid is guided to the outer edge of the interior of the centrifugal cylinder under the guidance of the plurality of liquid separation discs, light liquid is guided to the middle of the centrifugal cylinder, and the efficiency of separating the liquid medicine into light liquid and heavy liquid is improved;
3. solid-phase impurity in the liquid medicine deposits in the bottom outer fringe of centrifuge bowl under centrifugal force, when needs are cleared up these solid-phase impurity, supplies the clear water through controlling the second liquid pump toward the bath kneck, washes the solid-phase impurity of centrifuge bowl bottom, opens the drain valve after, makes the waste water that carries solid-phase impurity discharge along the drainage interface.
Drawings
Fig. 1 is a schematic perspective view of the present invention.
Fig. 2 is a half sectional view of a three-dimensional structure of the present invention.
Fig. 3 is an enlarged view of a portion a in fig. 2.
Fig. 4 is a front cross-sectional view of the inventive structure.
Fig. 5 is a schematic view of the present invention in operation.
Fig. 6 is an enlarged view at B in fig. 5.
In the figure: 1. a centrifugal cylinder; 101. a liquid inlet interface; 2. a support plate frame; 201. a pillar; 3. a separation tank; 301. a heavy liquid separation chamber; 3011. a first draft tube; 302. a mixed liquid separation chamber; 3021. a second draft tube; 303. a light liquid separation chamber; 4. a heavy liquid discharge port; 401. a mixed liquid discharge interface; 402. a light liquid discharge port; 5. a motor; 6. a rotating shaft; 7. a first turbine blade; 701. a second turbine blade; 8. a liquid separation disc set; 801. a liquid separation disc; 802. a liquid separation hole; 9. a solid phase baffle; 10. a three-way valve; 11. a first liquid pump; 12. a return pipe; 13. a flushing interface; 1301. a water drainage interface; 14. a second liquid pump; 15. a drain valve; 16. a link rod; 17. and supporting the rod piece.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides an extraction centrifugal mixing system based on bio-pharmaceuticals, which comprises a centrifugal cylinder 1, wherein a supporting plate frame 2 is welded on the outer wall of the middle part of the centrifugal cylinder 1, a plurality of supporting columns 201 are arranged on the lower surface of the supporting plate frame 2 for supporting, a liquid inlet connector 101 is arranged at the bottom of the centrifugal cylinder 1 and used for inputting liquid medicine into the centrifugal cylinder 1, and a separation box 3 is arranged at the top of the centrifugal cylinder 1.
The lower joint of the liquid inlet 101 is connected with a three-way valve 10, the lower port of the three-way valve 10 is connected with a first liquid pump 11, and the first liquid pump 11 is controlled to work to introduce the liquid medicine into the centrifuge tube 1 along the liquid inlet 101.
There is motor 5 at the top of separator box 3 through the bolt fastening, the output shaft of motor 5 runs through to separator box 3 inside perpendicularly downwards, and motor 5's output shaft end has the pivot 6 that extends to 1 inside of centrifuge tube through the coupling joint, the bottom of pivot 6 is equipped with first turbine flabellum 7 and second turbine flabellum 701, drive pivot 6 through motor 5, stir the liquid medicine of 1 inside of centrifuge tube and make the liquid medicine high-speed rotatory when first turbine flabellum 7 and the second turbine flabellum 701 of 6 bottoms of pivot rotate, upwards the water conservancy diversion with the liquid medicine simultaneously.
As shown in fig. 2 and 4, the separation tank 3 is divided into a heavy liquid separation chamber 301, a mixed liquid separation chamber 302, and a light liquid separation chamber 303 from bottom to top by a partition plate in sequence, a first flow guide pipe 3011 in a circular pipe shape is formed by bending the middle part of the partition plate between the heavy liquid separation chamber 301 and the mixed liquid separation chamber 302 downward, and a second flow guide pipe 3021 in a circular pipe shape is formed by bending the middle part of the partition plate between the mixed liquid separation chamber 302 and the light liquid separation chamber 303 downward.
One side of the heavy liquid separation chamber 301 is provided with a heavy liquid discharge port 4 communicated with each other for discharging heavy liquid stored in the heavy liquid separation chamber 301, one side of the light liquid separation chamber 303 is provided with a light liquid discharge port 402 communicated with each other for discharging light liquid stored in the light liquid separation chamber 303, one side of the mixed liquid separation chamber 302 is provided with a mixed liquid discharge port 401 communicated with each other, and an outer port of the mixed liquid discharge port 401 is connected with a side joint of the three-way valve 10 through a return pipe 12 for returning the mixed liquid stored in the mixed liquid separation chamber 302 to the interior of the centrifuge tube 1 for re-separation.
The lower part of the inner wall of the centrifugal cylinder 1 is welded with a solid-phase baffle 9, the solid-phase baffle 9 is a conical ring plate body with a concave middle part, and the solid-phase impurities in the liquid medicine are mainly at the outer edge of the bottom of the centrifugal cylinder 1, so that the solid-phase baffle 9 plays a role in blocking the solid-phase impurities and prevents the solid-phase impurities from rising.
Referring to fig. 1 and 2, a liquid separation disc set 8 is disposed in the middle of the centrifuge tube 1, the liquid separation disc set 8 is composed of a plurality of liquid separation discs 801 uniformly arranged in the vertical direction, the liquid separation discs 801 are conical ring plates with a convex middle portion, a plurality of liquid separation holes 802 are disposed in the middle of the liquid separation discs 801, the plurality of liquid separation discs 801 are welded and fixed by link rods 16, and the liquid separation discs 801 are welded and fixed with the inner wall of the centrifuge tube 1 by support rods 17, as shown in fig. 5 and 6, when liquid medicine is guided by each liquid separation disc set 8 of the liquid separation disc set 8, when the liquid medicine passes through the liquid separation holes 802 disposed in the middle of the liquid separation discs 801, heavy liquid is guided to the outer edge of the inside of the centrifuge tube 1, light liquid is guided to the middle of the centrifuge tube 1, and the efficiency of separating the liquid medicine into two phases of.
The bottom both sides of centrifuge bowl 1 are equipped with symmetrical bath interface 13 and drainage interface 1301 respectively, the outer port of bath interface 13 is connected with second liquid pump 14, the outer port of drainage interface 1301 is connected with drain valve 15, when the solid phase impurity clearance to centrifuge bowl 1 bottom, through opening drain valve 15, supply water through the work of second liquid pump 14 simultaneously, wash the solid phase impurity of centrifuge bowl 1 bottom, open behind the drain valve 15, make the waste water that carries solid phase impurity discharge along drainage interface 1301.
A centrifugation method for an extraction centrifugation mixing system for biopharmaceuticals, comprising the steps of:
the method comprises the following steps: the first liquid pump 11 is connected with a liquid medicine raw material input pipe, so that liquid medicine enters the interior of the centrifuge cylinder 1 along the liquid inlet connector 101 at the bottom of the centrifuge cylinder 1, the motor 5 drives the rotating shaft 6, the first turbine fan blade 7 and the second turbine fan blade 701 at the bottom of the rotating shaft 6 stir the liquid medicine, the liquid medicine rotates at a high speed, the liquid medicine is separated into two phases of heavy liquid and light liquid under the centrifugal force, the heavy liquid is gathered at the inner periphery of the centrifuge cylinder 1, the light liquid is gathered at the center of the centrifuge cylinder 1, the precision of the heavy liquid closer to the inner periphery of the centrifuge cylinder 1 is purer, the precision of the light liquid closer to the center of the centrifuge cylinder 1 is purer, when the liquid medicine rises, the heavy liquid close to the inner periphery of the centrifuge cylinder 1 enters the heavy liquid separation chamber 301 under the guidance of the first guide pipe 3011 and is discharged and separated by the heavy liquid discharge connector 4, and the light liquid close to the center of the centrifuge cylinder 1 enters the light liquid separation chamber 303 under the guidance of the second guide pipe 3021, the mixed liquid between the heavy liquid and the light liquid enters the mixed liquid separating chamber 302 under the guidance of the first guide pipe 3011 and the second guide pipe 3021, and flows back to the three-way valve 10 through the return pipe 12 connected to the mixed liquid discharging port 401 for re-separation;
step two: when the liquid medicine in the centrifuge tube 1 rises and passes through the liquid separation disc set 8, heavy liquid is guided to the outer edge of the interior of the centrifuge tube 1 under the guidance of the plurality of liquid separation discs 801, and light liquid is guided to the middle part of the centrifuge tube 1, so that the efficiency of separating the liquid medicine into light liquid and heavy liquid is improved;
step three: solid-phase impurities in the liquid medicine are deposited on the outer edge of the bottom of the centrifugal cylinder 1 under the action of centrifugal force, when the solid-phase impurities need to be cleaned, clear water is supplied to the flushing interface 13 through controlling the second liquid pump 14, the solid-phase impurities at the bottom of the centrifugal cylinder 1 are washed, and after the drain valve 15 is opened, waste water carrying the solid-phase impurities is discharged along the drain interface 1301.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments or portions thereof without departing from the spirit and scope of the invention.
Claims (10)
1. An extraction centrifugation hybrid system based on bio-pharmaceuticals is used, includes centrifuge tube (1), its characterized in that: the outer wall welding of the middle part of centrifuge bowl (1) has support grillage (2), and the lower surface of support grillage (2) is equipped with many spinal branchs post (201), the bottom of centrifuge bowl (1) is equipped with feed liquor interface (101), and the top of centrifuge bowl (1) is equipped with separator box (3).
2. The extraction centrifugation mixing system for biopharmaceuticals of claim 1, wherein: the lower connector of the liquid inlet interface (101) is connected with a three-way valve (10), and the lower port of the three-way valve (10) is connected with a first liquid pump (11).
3. The extraction centrifugation mixing system for biopharmaceuticals of claim 1, wherein: the top of separator box (3) is fixed with motor (5) through the bolt, and the output shaft of motor (5) is perpendicular to run through to inside separator box (3) downwards, and the output shaft end of motor (5) has pivot (6) that extend to centrifuge bowl (1) inside through the coupling joint, and the bottom of pivot (6) is equipped with first turbine flabellum (7) and second turbine flabellum (701).
4. The extraction centrifugation mixing system for biopharmaceuticals of claim 1, wherein: separator box (3) from down up in proper order by the baffle partition have heavy liquid separating chamber (301), mix liquid separating chamber (302) and light liquid separating chamber (303), and the downward bending in baffle middle part has first honeycomb duct (3011) between heavy liquid separating chamber (301) and mixed liquid separating chamber (302), and the downward bending in baffle middle part has second honeycomb duct (3021) between mixed liquid separating chamber (302) and light liquid separating chamber (303).
5. The extraction centrifugation mixing system for biopharmaceuticals of claim 4, wherein: heavy liquid discharge interfaces (4) communicated with each other are arranged on one side of the heavy liquid separation chamber (301), mixed liquid discharge interfaces (401) communicated with each other are arranged on one side of the mixed liquid separation chamber (302), light liquid discharge interfaces (402) communicated with each other are arranged on one side of the light liquid separation chamber (303), and the outer ports of the mixed liquid discharge interfaces (401) are connected with side connectors of the three-way valve (10) through return pipes (12).
6. The extraction centrifugation mixing system for biopharmaceuticals of claim 3, wherein: the centrifugal cylinder is characterized in that a solid-phase baffle (9) is welded to the lower portion of the inner wall of the centrifugal cylinder (1), and the solid-phase baffle (9) is a conical ring plate body with a concave middle portion.
7. An extraction centrifugal mixing system for biopharmaceutical based as in claim 3, wherein: the middle part of the centrifugal cylinder (1) is provided with a liquid separation disc group (8), the liquid separation disc group (8) is composed of a plurality of liquid separation discs (801) which are uniformly arranged along the vertical direction, the liquid separation discs (801) are conical ring plate bodies with the middle parts protruding upwards, and the middle parts of the liquid separation discs (801) are provided with a plurality of liquid separation holes (802).
8. The biopharmaceutical-based extraction centrifugation mixing system of claim 7, further comprising: the liquid separating discs (801) are welded and fixed by connecting rods (16), and the liquid separating discs (801) and the inner wall of the centrifugal cylinder (1) are welded and fixed by supporting rods (17).
9. The extraction centrifugation mixing system for biopharmaceuticals of claim 1, wherein: two sides of the bottom of the centrifugal cylinder (1) are respectively provided with a flushing interface (13) and a drainage interface (1301) which are symmetrical, an outer port of the flushing interface (13) is connected with a second liquid pump (14), and an outer port of the drainage interface (1301) is connected with a drainage valve (15).
10. A centrifugation method for a biopharmaceutical-based extraction centrifugation mixing system according to any of claims 1-9, comprising the steps of:
the method comprises the following steps: the first liquid pump (11) is connected with a liquid medicine raw material input pipe, so that liquid medicine enters the centrifugal cylinder (1) along a liquid inlet connector (101) at the bottom of the centrifugal cylinder (1), a motor (5) drives a rotating shaft (6) to stir the liquid medicine by a first turbine fan blade (7) and a second turbine fan blade (701) at the bottom of the rotating shaft (6), the liquid medicine rotates at a high speed, the liquid medicine is separated into a heavy liquid phase and a light liquid phase under centrifugal force, the heavy liquid is gathered at the inner outer edge of the centrifugal cylinder (1), the light liquid is gathered at the center of the centrifugal cylinder (1), the heavy liquid closer to the inner edge of the centrifugal cylinder (1) is purer in precision and the light liquid closer to the center of the centrifugal cylinder (1) is purer in precision under centrifugal acting force, and when the liquid medicine rises, the heavy liquid closer to the inner edge of the centrifugal cylinder (1) enters a heavy liquid separation chamber (301) under the guidance of a first guide pipe (3011), the heavy liquid is discharged and separated through the heavy liquid discharging interface (4), the light liquid close to the center of the centrifugal cylinder (1) enters the light liquid separating chamber (303) under the guidance of the second guide pipe (3021) and is discharged and separated through the light liquid discharging interface (402), the mixed liquid between the heavy liquid and the light liquid enters the mixed liquid separating chamber (302) under the guidance of the first guide pipe (3011) and the second guide pipe (3021), and the return pipe (12) connected with the mixed liquid discharging interface (401) returns to the three-way valve (10) for re-separation;
step two: when the liquid medicine in the centrifugal cylinder (1) rises and passes through the liquid separation disc set (8), heavy liquid is guided to the outer edge of the interior of the centrifugal cylinder (1) under the guidance of the plurality of liquid separation discs (801), and light liquid is guided to the middle of the centrifugal cylinder (1), so that the efficiency of separating the liquid medicine into light liquid and heavy liquid is improved;
step three: solid-phase impurities in the liquid medicine are deposited on the outer edge of the bottom of the centrifugal cylinder (1) under the action of centrifugal force, when the solid-phase impurities need to be cleaned, clear water is supplied to a flushing interface (13) by controlling a second liquid pump (14), the solid-phase impurities at the bottom of the centrifugal cylinder (1) are washed, and after a drain valve (15) is opened, waste water carrying the solid-phase impurities is discharged along a drainage interface (1301).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110042228.7A CN112755588A (en) | 2021-01-13 | 2021-01-13 | Extraction centrifugal mixing system based on bio-pharmaceuticals and centrifugal method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110042228.7A CN112755588A (en) | 2021-01-13 | 2021-01-13 | Extraction centrifugal mixing system based on bio-pharmaceuticals and centrifugal method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112755588A true CN112755588A (en) | 2021-05-07 |
Family
ID=75700067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110042228.7A Pending CN112755588A (en) | 2021-01-13 | 2021-01-13 | Extraction centrifugal mixing system based on bio-pharmaceuticals and centrifugal method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112755588A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115450729A (en) * | 2022-10-24 | 2022-12-09 | 苏州恩都法汽车系统有限公司 | Centrifugal oil-gas separator and engine system |
| CN115501789A (en) * | 2022-09-27 | 2022-12-23 | 浙江威仕生物科技有限公司 | Purification equipment of coenzyme Q10 |
| CN116282325A (en) * | 2023-05-19 | 2023-06-23 | 江西省农业科学院农产品质量安全与标准研究所 | Pesticide separation and extraction device in water |
| CN116688562A (en) * | 2023-06-14 | 2023-09-05 | 苏州肤莱特生物科技有限公司 | Cosmetic raw material extraction device and extraction method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN207856379U (en) * | 2018-01-19 | 2018-09-14 | 浙江维雅化妆品有限公司 | The extraction equipment of one Plant Extracts |
| CN210367596U (en) * | 2019-08-01 | 2020-04-21 | 张汉兵 | A equipment for separating edible oil |
-
2021
- 2021-01-13 CN CN202110042228.7A patent/CN112755588A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN207856379U (en) * | 2018-01-19 | 2018-09-14 | 浙江维雅化妆品有限公司 | The extraction equipment of one Plant Extracts |
| CN210367596U (en) * | 2019-08-01 | 2020-04-21 | 张汉兵 | A equipment for separating edible oil |
Non-Patent Citations (1)
| Title |
|---|
| 宋立杰等: "《冶金企业废弃生产设备设施处理与利用》", 28 February 2009 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115501789A (en) * | 2022-09-27 | 2022-12-23 | 浙江威仕生物科技有限公司 | Purification equipment of coenzyme Q10 |
| CN115450729A (en) * | 2022-10-24 | 2022-12-09 | 苏州恩都法汽车系统有限公司 | Centrifugal oil-gas separator and engine system |
| CN115450729B (en) * | 2022-10-24 | 2023-11-03 | 苏州恩都法汽车系统股份有限公司 | Centrifugal oil-gas separator and engine system |
| CN116282325A (en) * | 2023-05-19 | 2023-06-23 | 江西省农业科学院农产品质量安全与标准研究所 | Pesticide separation and extraction device in water |
| CN116688562A (en) * | 2023-06-14 | 2023-09-05 | 苏州肤莱特生物科技有限公司 | Cosmetic raw material extraction device and extraction method thereof |
| CN116688562B (en) * | 2023-06-14 | 2024-02-06 | 苏州肤莱特生物科技有限公司 | Cosmetic raw material extraction device and extraction method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112755588A (en) | Extraction centrifugal mixing system based on bio-pharmaceuticals and centrifugal method thereof | |
| CN106731086A (en) | The chemical solution filter machine that a kind of impurity is convenient to clean | |
| CN209631423U (en) | A kind of medical fluid centrifuge | |
| CN109675727A (en) | Multistage dish-style cyclone separator | |
| CN117443085B (en) | Raw material separation equipment for processing new energy automobile cooling liquid | |
| CN107717623B (en) | A kind of cooling liquid filtering apparatus for the machining being conducive to protect environment | |
| CN110835146A (en) | Multistage circular plate type solid-liquid separation or dust removal machine | |
| CN110143689A (en) | A kind of sewage treatment filter plant | |
| CN206008563U (en) | A kind of herbicide production preparing tank | |
| CN112156520A (en) | Wastewater suspended matter rapid separation device for livestock and poultry breeding industry and use method thereof | |
| CN209577056U (en) | Multistage dish-style cyclone separator | |
| CN218421135U (en) | Traditional chinese medicine centrifugal extraction device | |
| CN203079769U (en) | Combined type double spiral-flow high-efficiency turbid water purifying device | |
| CN108452587A (en) | A kind of filter centrifugal | |
| CN205204956U (en) | Mud separator | |
| CN210247862U (en) | Milk degreasing machine | |
| CN210409580U (en) | Multifunctional extraction device | |
| CN208694448U (en) | A kind of filter centrifugal | |
| CN207276288U (en) | Membrane bioreactor | |
| CN220116483U (en) | Extraction device for refining mugwort leaf essential oil | |
| CN220513643U (en) | Solid-liquid separation device for medicine processing | |
| CN109985415B (en) | Efficient energy-saving automatic control extraction system and extraction method thereof | |
| CN215586067U (en) | Lifting mixing and stirring tank applied to CCD thickener | |
| CN214936462U (en) | Waste water recovery system of thermal power plant | |
| CN215275917U (en) | Microalgae extraction device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210507 |