CN112754499A - System and method for synchronously recording electrophysiological signals of brain and spinal cord - Google Patents

System and method for synchronously recording electrophysiological signals of brain and spinal cord Download PDF

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CN112754499A
CN112754499A CN202110100113.9A CN202110100113A CN112754499A CN 112754499 A CN112754499 A CN 112754499A CN 202110100113 A CN202110100113 A CN 202110100113A CN 112754499 A CN112754499 A CN 112754499A
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brain
spinal cord
electrophysiological
signals
electrophysiological signals
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胡理
王飞雪
夏晓磊
曾予璿
岳路鹏
张立波
吕雪靖
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Institute of Psychology of CAS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6802—Sensor mounted on worn items
    • A61B5/6803—Head-worn items, e.g. helmets, masks, headphones or goggles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
    • A61B5/6877—Nerve
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/725—Details of waveform analysis using specific filters therefor, e.g. Kalman or adaptive filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7253—Details of waveform analysis characterised by using transforms
    • A61B5/7257—Details of waveform analysis characterised by using transforms using Fourier transforms

Abstract

The invention discloses a system and a method for synchronously recording electrophysiological signals of a brain and a spinal cord, wherein the system comprises the following steps: the system comprises a spinal cord electrophysiological signal acquisition device, a brain electrophysiological signal collection device, an electrophysiological signal integration device and a data storage device; the method is relatively simple, and the electrode plate placed outside the spinal cord dura mater can adopt the part which is implanted into the tested body, so that the method has good safety and can accurately acquire the activity condition of the central nervous system.

Description

System and method for synchronously recording electrophysiological signals of brain and spinal cord
Technical Field
The invention relates to the technical field of physiological signal processing, in particular to a system and a method for synchronously recording electrophysiological signals of a brain and a spinal cord.
Background
The central nervous system is an important part of the nervous system, including the brain and spinal cord. The central nervous system is not only responsible for acquiring and integrating external information, but also can regulate and control behaviors and activities of people from top to bottom, and plays an important role in adapting to the environment and developing individuals of human beings, so that the central nervous system has important significance in fully researching and understanding the central nervous system. In addition to cancer and cardiovascular and cerebrovascular diseases, diseases caused by damage and disorders of the central nervous system are currently the biggest threats to human health worldwide.
There are many techniques available to study the brain in a non-invasive manner, including electroencephalography (EEG) and Magnetoencephalography (MEG), which can directly record brain activity, and Positron Emission Tomography (PET) and functional magnetic resonance techniques (fMRI), which measure brain activity indirectly. Using these techniques, researchers have conducted a great deal of research into the brain. However, current research approaches to the spinal cord are very limited, which also makes the research on the spinal cord relatively slow and essentially focused on animal models.
Considering the important role of the spinal cord in the somatosensory and motor systems, the recording of spinal cord electric signals and the brain-spinal cord synchronous electric signal recording based on the spinal cord electric signals have important significance for the basic research related to the somatosensory and motor systems and the clinical disease research.
Disclosure of Invention
In order to solve the technical problems, the collected spinal cord and brain signals are synchronously recorded, the activity condition of the central nervous system is accurately mastered, and the correlation analysis of the somatosensory and motor systems of people is realized.
The invention adopts the following technical scheme:
in one aspect, the present invention provides a system for simultaneously recording electrophysiological signals of the brain and spinal cord, the system comprising:
the spinal cord electrophysiological signal acquisition device is used for acquiring spinal cord electrophysiological signals generated outside a human spinal cord epidural;
the brain electrical physiological signal collecting device is used for collecting brain electrical physiological signals generated by the brain of a human body;
the electrophysiological signal integration device is respectively connected with the spinal cord electrophysiological signal acquisition device and the brain electrophysiological signal collection device and is used for synchronously integrating the electrophysiological signals of the brain and the spinal cord which are acquired simultaneously;
and the data storage device is connected with the electrophysiological signal integration device and is used for storing the electrophysiological signals of the brain and the spinal cord integrated by the electrophysiological signal integration device.
The system further comprises a data processor which is electrically connected with the electrophysiological signal integration device and the data storage device respectively, wherein a preprocessing module is arranged in the data processor and used for preprocessing the originally acquired electrophysiological signals and storing the preprocessed electrophysiological signals into the data storage device.
Preferably, the preprocessing module comprises a re-referencing module and a denoising module, and is configured to sequentially re-reference and denoise the electrophysiological signals integrated by the electrophysiological signal integration device.
Furthermore, the system also comprises a display device connected with the data storage device, and the display device is used for displaying the electrophysiological signals of the computer and the spinal cord after synchronous processing.
Preferably, the data processor further comprises a power spectral density analysis module for analyzing the differences and correlations between the brain and spinal cord electrophysiological signals in the respective frequency bands, and displaying the differences and correlations via the display device.
The data processor also comprises a brain-spinal cord function correlation analysis module, and the preprocessed electrophysiological signals are analyzed by adopting a delay part directional coherent analysis method to obtain the correlation degree between the brain signals and the spinal cord signals, and the correlation degree is displayed by the display device.
The data storage device, the data processor and the display device are integrated in a computer terminal.
The spinal cord electrophysiological signal acquisition device comprises a plurality of electrode plates which are implanted or to be implanted into a human body, and the electrode plates are electrically connected with the electrophysiological signal integration device through spinal cord electrical signal leads.
The large brain electrical physiological signal collecting device is a brain electrical cap and is electrically connected with the electrophysiological signal integrating device through a brain electrical signal lead.
The electrophysiological signal integration device comprises an electrode access box, an amplifier and a signal output lead, the spinal cord electrophysiological signal acquisition device and the brain electrophysiological signal collection device are respectively electrically connected with the electrode access box through the electrode lead, the amplifier is electrically connected with the electrode access box, one end of the signal output lead is electrically connected with the discharger, and the other end of the signal output lead is electrically connected with the data storage device.
In another aspect, the present invention also provides a method for simultaneously recording electrophysiological signals of the brain and spinal cord, the method comprising the steps of:
step 1, respectively implanting electrode plates in a spinal cord electrophysiological signal acquisition device outside a dura mater of a tested spinal cord, and simultaneously wearing a brain electrophysiological signal collection device on the head of the tested spinal cord;
step 2, respectively connecting the electrode plate and the brain electrophysiological signal collecting device to an electrophysiological signal integrating device through electrode leads;
and 3, starting the spinal cord electrophysiological signal collection device and the brain electrophysiological signal collection device, synchronously integrating the collected electrophysiological signals of the brain and the spinal cord through the electrophysiological signal integration device, and storing the integrated electrophysiological signals in the data storage device.
And (3) inputting the brain electrophysiological signals and the spinal cord electrophysiological signals collected in the step (3) into an electrode access box, sequentially performing signal amplification, re-reference and denoising pretreatment through an amplifier and a data processor, and displaying the pretreated electrophysiological signals through a display device.
The re-reference processing in the step 3 provides 1-100 Hz band-pass filtering and 48-52 Hz concave filtering, and the denoising processing removes eye movement artifacts, head movement artifacts and heartbeat noise through an independent component analysis algorithm.
The method also comprises a step 4 of analyzing the power spectral density of the electrophysiological signals of the brain and the spinal cord: converting the preprocessed electrophysiological signal time domain information into frequency domain information through fast Fourier transform, and standardizing each frequency energy of a single electrode by using the total energy of a frequency spectrum as a standard; dividing a frequency spectrum into a plurality of continuous frequency bands; the differences and correlations between the electrophysiological signals of the brain and spinal cord in the respective frequency bands are compared and displayed by a display device.
The technical scheme of the invention has the following advantages:
A. the system established by the invention is established on two technologies which are already applied in clinical maturity, namely spinal cord electrical stimulation and electroencephalogram. The invention adopts the spinal cord electrophysiological signal collection device and the brain electrophysiological signal collection device to simultaneously collect the signals, and the electrophysiological signals are synchronously integrated by the electrophysiological signal integration device, thereby achieving the purpose of synchronously recording the electrophysiological signals of the brain and the spinal cord.
B. When the electrophysiological signals of the brain and the spinal cord are synchronously recorded, the output leads of the spinal cord electrophysiological signal acquisition device and the brain electrophysiological signal collection device are both connected into the same electrode access box, so that the complexity of the system is greatly simplified; on the other hand, the electrode access box, the amplifier and other subsequent data processors use the same set, and have higher contrast when the brain-spinal cord electrophysiological signal is analyzed.
Drawings
In order to more clearly illustrate the embodiments of the present invention, the drawings which are needed to be used in the embodiments will be briefly described below, and it is apparent that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained from the drawings without inventive labor to those skilled in the art.
FIG. 1 is a diagram illustrating a connection structure of devices in a system provided by the present invention;
FIG. 2 is a block diagram of a method provided by the present invention;
FIG. 3 is a graph of a comparison of electrophysiological signals from the brain and spinal cord after treatment by the system of the present invention;
FIG. 4 is a graph of electrophysiological signal distribution over various frequency bands for the brain and spinal cord under resting open and closed eye conditions;
fig. 5 is a block diagram of the integrated processing of the collected brain-spinal cord electrophysiological signals of the present invention.
In the figure:
1-a spinal cord electrophysiological signal acquisition device; 2-spinal cord electrical signal leads; 3-electrophysiological signal integration device, 31-electrode access box, 32-amplifier; 4-a brain electrophysiological signal collection device; 5-brain electrical signal leads; 6-signal output conductors; 7-computer terminal.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it should be understood that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the present invention without making any creative effort, shall fall within the protection scope of the present invention.
As shown in fig. 1, the present invention provides a system for simultaneously recording electrophysiological signals of the brain and spinal cord, comprising: the device comprises a spinal cord electrophysiological signal acquisition device 1, a brain electrophysiological signal collection device 4, an electrophysiological signal integration device 3 and a data storage device. The spinal cord electrophysiological signal acquisition device 1 is used for acquiring spinal cord electrophysiological signals generated outside a human spinal cord epidural; the brain electrical physiological signal collecting device 4 is used for collecting brain electrical physiological signals generated by the brain of a human body; the electrophysiological signal integration device 3 is electrically connected with the spinal cord electrophysiological signal acquisition device through a spinal cord electrical signal lead 2, the brain electrophysiological signal collection device 4 is electrically connected with the electrophysiological signal integration device 3 through a brain electrical signal wire 5, and the electrophysiological signal integration device 3 is used for synchronously integrating the electrophysiological signals of the brain and the spinal cord which are acquired simultaneously; the data storage device is connected with the electrophysiological signal integration device and is used for storing the electrophysiological signals of the brain and the spinal cord integrated by the electrophysiological signal integration device 3. The data storage device is preferably a computer terminal 7 or the like, such as a computer having storage, data processing and display functions.
The spinal cord electrophysiological signal collection device 1 here includes a plurality of electrode pads implanted in the human body, which are electrically connected to the electrophysiological signal integration device 3 via the spinal cord electrical signal conductor 2. The spinal cord electrophysiological signal collection device 1 adopted in the invention is modified according to a technology which is clinically and mature to be applied, namely a spinal cord electrical stimulator. The spinal cord electric stimulator comprises an in-vivo implantation part and an in-vitro control part: the in-vivo implanted part consists of an electrode plate and a lead; the external control part consists of an electrode box, a test cable connector and an external nerve electrical stimulator. When in reconstruction, the original implanted part in the body is kept, and the test cable lead of the external control part and the external nerve stimulator are removed. And welding the output lead with a test cable of an external control part of the spinal cord electric stimulator body, and wrapping the test cable with an insulating tape.
The brain electrical physiological signal collecting device 4 is a brain electrical cap, which is the prior art, and the brain electrical cap is electrically connected with the electrophysiological signal integrating device 3 through a brain electrical signal lead 5. The brain electric cap comprises AgCl electrodes, leads connected with the electrodes and an electrode cap for fixing the electrodes on the surface of the scalp. The electrode slice for collecting the brain electrophysiological signals can be directly placed and tightly attached to the scalp of a person to be collected, or a medium such as conductive paste is used between the scalp and the electrode to reduce the electrical impedance rate. 21, 32 and 64 electrodes can be used, or the number of the electrodes and the positions of the electrodes on the scalp can be selected according to the signal acquisition requirements. The spinal epidural electrodes may be implanted for medical reasons, adapted for signal collection under appropriate conditions, or implanted for collecting spinal cord signals. The number and location of the implanted electrodes can be selected as required for signal acquisition.
The electrophysiological signal integration device 3 includes an electrode access box 31, an amplifier 32 and a signal output lead 6, the spinal cord electrophysiological signal collection device 1 and the brain electrophysiological signal collection device 4 are electrically connected to the electrode access box 31 through the corresponding electrode leads, respectively, the amplifier 32 is electrically connected to the electrode access box 31, one end of the signal output lead 6 is electrically connected to the discharger 32, and the other end thereof is electrically connected to the data storage device. The amplifier 32 can amplify the signal collected by the electrode access box 31, so that the electrophysiological signal with better quality is collected at the near end of the human body, and the signal-to-noise ratio of the output signal passing through the signal output lead 6 is reduced after amplification. The electrode access box 31 used here is prior art and will not be described in detail.
As shown in fig. 5, the system of the present invention further comprises a data processor electrically connected to the electrophysiological signal integration device and the data storage device, respectively, wherein the data processor is provided with a preprocessing module for preprocessing the originally acquired electrophysiological signal and storing the preprocessed electrophysiological signal in the data storage device. The preprocessing module comprises a re-reference module and a denoising module and is used for sequentially re-referencing and denoising the electrophysiological signals integrated by the electrophysiological signal integration device.
In order to facilitate external presentation, the system is also provided with a display device which is connected with the data storage device and used for displaying the electrophysiological signals of the computer and the spinal cord after synchronous processing.
Furthermore, the invention also provides a function of analyzing the acquired electrophysiological original signals of the brain and the spinal cord, a power spectral density analysis module and/or a brain-spinal cord function correlation analysis module is arranged in the data processor, the power spectral density analysis module is used for analyzing the difference between the electrophysiological signals of the brain and the spinal cord in each frequency band, the brain-spinal cord function correlation analysis module adopts a delay part directional coherent analysis method to analyze the preprocessed electrophysiological signals, so as to obtain the correlation degree between the brain signals and the spinal cord signals, and the analysis result is displayed by a display device.
The data storage device, the data processor and the display device are integrated in a computer terminal 7. The electrophysiological information can be read in real time on a computer display screen, the collection quality of the electrophysiological information is judged, preliminary signal analysis is performed, and the required electrophysiological signals can be stored according to requirements.
8 patients treated with post-herpes zoster chronic pain by spinal cord electrical stimulation were recruited, each patient having implanted 8 electrodes for spinal cord electrical stimulation treatment at different locations of the spinal cord depending on their different chronic pain locations (E1-E8). The 8 enrolled subjects had no history of neurological or dementia, mental disorders or psychiatric diseases, and the age ranged from 53 to 84 years, the average age was 68.1 ± 8.7 years, of which 5 were females and 3 were males.
During the experiment, the subject was scheduled to sit in a quiet and temperature comfortable room. The experiment included two parts: an open eye portion and a closed eye portion. In the eye-closing part, the subject was asked to close his eyes for 3 minutes, and to remain relaxed but not to sleep. At the eye-open part, the subject is asked to remain relaxed, looking at the fixation point on the computer screen for 3 minutes. The order of open and closed eyes was balanced between the trials.
The method for synchronously recording the electrophysiological signals of the brain and the spinal cord, provided by the invention, comprises the following steps:
(S01) respectively implanting electrode pads in the spinal cord electrophysiological signal acquisition device outside the dura mater of the tested spinal cord, and simultaneously wearing a brain electrophysiological signal collection device on the head of the tested spinal cord. After 7-10 days after the spinal cord electrical stimulation implantation is completed (at the moment, the tested spinal cord electrical stimulation is stopped, and the treatment does not feel pain), the electrodes originally implanted outside the dura mater of the tested spinal cord are reserved, the test cable lead of the spinal cord electrical stimulator and the external nerve stimulator are detached, the test cable is welded with the lead of the other accessible electrode access box, and the insulating wire is wrapped.
According to the international 1020-system electroencephalogram, for example, 21 AgCl electrodes (FPz, FP1, FP2, Fz, F3, F4, Cz, C3, C4, Pz, P3, P4, Oz, O1, O2, P7, P8, T7, T8, F7, F8) are placed on the scalp to be tested.
(S02) the electrode plate and the brain electrophysiological signal collection device are respectively connected to the electrophysiological signal integration device through electrode leads. 8 electrode leads of the spinal cord electrophysiological signal collection device and 21 electrode leads of the brain electrophysiological signal collection device are all connected into the electrode box, connected with the amplifier and connected with the computer through the output leads. Preferably, the recorded band-pass filtering is 1-1000 Hz, and the sampling rate is 5000 Hz.
And (S03) starting the spinal cord electrophysiological signal collection device and the brain electrophysiological signal collection device, synchronously integrating the acquired electrophysiological signals of the brain and the spinal cord through the electrophysiological signal integration device, storing the integrated electrophysiological signals in the data storage device, and storing the electrophysiological signals synchronously recorded by the brain and the spinal cord.
The electrophysiological signals recorded synchronously by the brain-spinal cord stored in the way can be used for carrying out subsequent combined comparative analysis on the electrophysiological signals of the brain-spinal cord in a resting state, including comparison of the power spectral densities of open and closed eyes of the brain and the spinal cord in the resting state and exploration of functional connection of the brain-spinal cord.
For subsequent data analysis, firstly, preprocessing the stored original signals, including re-referencing, 1-100 Hz band-pass filtering and 48-52 Hz recess filtering, removing eye movement artifacts, head movement artifacts and heartbeat noise by an independent component analysis algorithm, wherein the processed brain and spinal cord electrophysiological signals are shown in FIG. 3. It can be seen from the results shown in fig. 3 that good electrophysiological signals of the brain and spinal cord can be collected using the device and method of the present invention.
Analyzing the open-closed eye power spectral density of the brain and spinal cord at rest state [ S04 ] comprising the steps of:
(S041) transforming the preprocessed electrophysiological time domain information into 1-100 Hz frequency domain information through fast Fourier transform;
(S042) standardizing each frequency energy of a single electrode by using the total energy of the frequency spectrum of 1-100 Hz as a standard;
s043, the frequency spectrum is divided into 6 frequency bands: delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), beta (12-30 Hz), low-frequency gamma (30-50 Hz), and high-frequency gamma (50-100 Hz);
(S044) comparing differences and correlations of brain and spinal cord electrophysiological signals for respective frequency bands under open-eye and closed-eye conditions.
The results are shown in FIG. 4: under the resting eye opening and eye closing conditions, the brain and the spinal cord have similar electrophysiological signals, namely, the power spectrum density of a delta frequency band is larger when eyes are opened, the power spectrum energy of an alpha frequency band is larger when eyes are closed, and the rest frequency bands have no significant difference. The results further illustrate that the system and method provided by the present invention can collect good brain-spinal cord electrophysiological signals, and the signals synchronously collected by the method have high reliability and contrast when performing contrast analysis.
The brain-spinal cord function correlation analysis module arranged in the data processor is used for researching brain-spinal cord function correlation, uses delayed partial directional coherent analysis (lPDC), and comprises the following steps:
the preprocessed data is down-sampled to 200Hz, and modeling is carried out by using a formula 1;
Figure BDA0002915574470000091
in the formula 1, [ X ]1(t),X2(t)]Representing brain and spinal signals;
[u1(t),u2(t)]is uncorrelated gaussian noise, representing the residual error of the model;
b (r) is a coefficient of multivariate autoregressive (MVAR) describing the degree of correlation between X (t) and X (t-r) (r ≠ 1,2, …, p), excluding the coefficients associated with transient effects in the desired spectral causal calculations (e.g., r ≠ 0);
p is determined by the Chi-pool information criterion and is the number of time points for the maximum sample before t in model X (t).
From equation 1, the model residual u can be derived1(t)、u2(t) and coefficient of multiple autoregressive (MVAR) B (r).
Value of lPDC, i.e. | Ci←j(f) I, determined by equation 2;
Figure BDA0002915574470000092
in the formula 2, Bij(f) Is the fourier transform of the MVAR coefficients, i.e. b (r) in formula 1;
σkrepresents the standard deviation of the model residuals, k is 1,2, …, i;
combining the formula 1 and the formula 2 to obtain the IPDC value. The range of the lPDC is between 0 and 1, 0 represents that a source j has no influence on a target i, 1 represents that the source j has high linear prediction degree on the target i, and electrophysiological signals of a brain and a spinal cord can be used as the source j and the target i. Through the brain-spinal cord function correlation analysis, the linear prediction degree can be displayed through a display screen of a computer terminal.
By using the analysis method, the signals from the spinal cord to the brain are not obviously coherent in each frequency band, and the signals from the brain to the spinal cord are obviously coherent in delta and alpha frequency bands (particularly in the delta frequency band), which indicates that the electrophysiological signals of the spinal cord are regulated and controlled by the brain from top to bottom in the resting state. The result shows that the system and the method can not only collect the brain and spinal cord data with higher quality, but also carry out combined processing on the brain and spinal cord data so as to research the neural activity in the central nervous system of the human body.
It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are intended to be within the scope of the invention.

Claims (14)

1. A system for simultaneously recording electrophysiological signals of the brain and spinal cord, the system comprising:
the spinal cord electrophysiological signal acquisition device is used for acquiring spinal cord electrophysiological signals generated outside a human spinal cord epidural;
the brain electrical physiological signal collecting device is used for collecting brain electrical physiological signals generated by the brain of a human body;
the electrophysiological signal integration device is respectively connected with the spinal cord electrophysiological signal acquisition device and the brain electrophysiological signal collection device and is used for synchronously integrating the electrophysiological signals of the brain and the spinal cord which are acquired simultaneously;
and the data storage device is connected with the electrophysiological signal integration device and is used for storing the electrophysiological signals of the brain and the spinal cord integrated by the electrophysiological signal integration device.
2. The system for synchronously recording electrophysiological signals of the brain and spinal cord according to claim 1, further comprising a data processor electrically connected to the electrophysiological signal integration device and the data storage device, respectively, wherein the data processor is provided with a preprocessing module for preprocessing the originally acquired electrophysiological signals and storing the preprocessed electrophysiological signals in the data storage device.
3. The system for synchronously recording electrophysiological signals of the brain and spinal cord as claimed in claim 2, wherein the preprocessing module comprises a re-referencing module and a de-noising module for sequentially re-referencing and de-noising the electrophysiological signals integrated by the electrophysiological signal integration device.
4. The system for synchronously recording electrophysiological signals of the brain and spinal cord of claim 3, further comprising a display device coupled to the data storage device, the display device configured to display the electrophysiological signals of the brain and spinal cord after synchronous processing.
5. The system for simultaneously recording electrophysiological signals of the brain and spinal cord according to claim 4, wherein the data processor further comprises a power spectral density analysis module for analyzing differences and correlations between electrophysiological signals of the brain and spinal cord in each frequency band, and displaying the differences and correlations on the display device.
6. The system for synchronously recording electrophysiological signals of the brain and spinal cord as claimed in claim 5, wherein the data processor further comprises a brain-spinal cord function correlation analysis module for analyzing the preprocessed electrophysiological signals by a delayed partially directional coherence analysis method to obtain the correlation between the brain signals and the spinal cord signals, and displaying the correlation through the display device.
7. The system for simultaneously recording electrophysiological signals of the brain and spinal cord according to any of claims 1 to 6, wherein the data storage device, the data processor, and the display device are integrated into a computer terminal.
8. The system for synchronously recording electrophysiological signals of the brain and spinal cord according to any of claims 1 to 6, wherein the device for collecting electrophysiological signals of the spinal cord comprises a plurality of electrode pads implanted or to be implanted in the body, and the electrode pads are electrically connected to the device for integrating electrophysiological signals via electrical leads of the spinal cord.
9. The system for synchronously recording electrophysiological signals of the brain and spinal cord according to any of claims 1 to 6, wherein the electroencephalogram physiological signal collection device is an electroencephalogram cap electrically connected to the electrophysiological signal integration device via an electrical brain signal lead.
10. The system for synchronously recording electrophysiological signals of the brain and spinal cord according to any of claims 1 to 6, wherein the electrophysiological signal integration device comprises an electrode access box, an amplifier and a signal output lead, the spinal cord electrophysiological signal collection device and the brain electrophysiological signal collection device are electrically connected to the electrode access box through the electrode lead, respectively, the amplifier is electrically connected to the electrode access box, one end of the signal output lead is electrically connected to the discharger, and the other end of the signal output lead is electrically connected to the data storage device.
11. A method of simultaneously recording electrophysiological signals from the brain and spinal cord, comprising the steps of:
step 1, respectively implanting electrode plates in a spinal cord electrophysiological signal acquisition device outside a dura mater of a tested spinal cord, and simultaneously wearing a brain electrophysiological signal collection device on the head of the tested spinal cord;
step 2, respectively connecting the electrode plate and the brain electrophysiological signal collecting device to an electrophysiological signal integrating device through corresponding electrode leads;
and 3, starting the spinal cord electrophysiological signal collection device and the brain electrophysiological signal collection device, synchronously integrating the collected electrophysiological signals of the brain and the spinal cord through the electrophysiological signal integration device, and storing the integrated electrophysiological signals in the data storage device.
12. The method for synchronously recording the electrophysiological signals of the brain and the spinal cord as claimed in claim 11, wherein the electrophysiological signals of the brain and the spinal cord collected in step 3 are input to the electrode access box, sequentially undergo signal amplification, re-referencing and de-noising preprocessing by the amplifier and the data processor, and the preprocessed electrophysiological signals are displayed on the display device.
13. The method for synchronously recording electrophysiological signals of the brain and spine according to claim 12, wherein the re-referencing in step 3 provides band-pass filtering at 1-100 Hz and notch filtering at 48-52 Hz, and wherein the de-noising removes eye movement artifacts, head movement artifacts, and noise of heartbeat by an independent component analysis algorithm.
14. The method for synchronously recording brain and spinal electrophysiological signals of claim 13, further comprising the step of analyzing the power spectral density of the brain and spinal electrophysiological signals of step 4: converting the preprocessed electrophysiological signal time domain information into frequency domain information through fast Fourier transform, and standardizing each frequency energy of a single electrode by using the total energy of a frequency spectrum as a standard; dividing a frequency spectrum into a plurality of continuous frequency bands; the differences and correlations between the electrophysiological signals of the brain and spinal cord in the respective frequency bands are compared and displayed by a display device.
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CN113426007A (en) * 2021-05-17 2021-09-24 浙江大学 Closed-loop epidural electrical stimulation system for upper limb functional recovery

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113426007A (en) * 2021-05-17 2021-09-24 浙江大学 Closed-loop epidural electrical stimulation system for upper limb functional recovery
CN113426007B (en) * 2021-05-17 2024-04-19 浙江大学 Closed-loop dura mater external electric stimulation system for upper limb function recovery

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