CN112742313A - Aerosol generating system, aerosol generating method, inflammation therapeutic apparatus and application thereof - Google Patents

Aerosol generating system, aerosol generating method, inflammation therapeutic apparatus and application thereof Download PDF

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CN112742313A
CN112742313A CN202011611669.6A CN202011611669A CN112742313A CN 112742313 A CN112742313 A CN 112742313A CN 202011611669 A CN202011611669 A CN 202011611669A CN 112742313 A CN112742313 A CN 112742313A
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林金明
林海锋
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Tsinghua University
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/0095—Preparation of aerosols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A61M35/30—Gas therapy for therapeutic treatment of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/44—Applying ionised fluids

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Abstract

The invention discloses an aerosol generation system, an aerosol generation method, an inflammation therapeutic apparatus and application thereof. The aerosol generating system comprises a discharge unit, a fluid unit and a mixing cavity; the discharging unit comprises a discharging generator, a voltage conveying device and a voltage releasing port which are connected in sequence; the voltage release port is located in the mixing cavity; the fluid unit comprises a storage device and a fluid flow chamber; a fluid release port is arranged on the storage device, and the side wall of the fluid flow chamber is communicated with the storage device through the fluid release port; one end of the fluid flowing chamber is provided with an air inlet, and the other end of the fluid flowing chamber is communicated with the mixing cavity. The system provided by the invention has high-efficiency sterilization and anti-inflammation effects, less reagent consumption and lower cost, and can weaken the toxicity hazard of the bacteriostatic agent.

Description

Aerosol generating system, aerosol generating method, inflammation therapeutic apparatus and application thereof
Technical Field
The invention relates to the field of medical instruments, in particular to an aerosol generating system and an aerosol generating method, an inflammation therapeutic apparatus comprising the aerosol generating system and application of the inflammation therapeutic apparatus.
Background
In life, people are often plagued with infectious inflammations caused by biological pathogens such as bacteria, viruses, rickettsia, mycoplasma, fungi and parasites, and the pain and itching caused by these inflammations severely disturb people's lives.
At present, the method for treating the inflammation is the most effective method for eliminating pathogenic bacteria at the affected part of the inflammation in time besides oral anti-inflammatory drugs. Wherein, the mode of directly coating bacteriostatic agent can be adopted to eliminate pathogenic bacteria at the inflammatory affected part. Meanwhile, the specific surface area of the anti-inflammatory effect can be obviously increased by the mode of applying the medicine in a non-direct contact gasification mode. However, the wide use of bacteriostatic agents leads to an increase in the resistance of bacteria, and thus, the desired antibacterial effect cannot be obtained with the passage of time.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides an aerosol generation system, an aerosol generation method, an inflammation therapeutic apparatus comprising the aerosol generation system and application of the inflammation therapeutic apparatus. The aerosol generating system can generate negative ions by ionizing air or oxygen and other gases, can ionize a gaseous or liquid bacteriostatic agent to obtain a mixed aerosol of the ionized bacteriostatic agent and the negative ions, and realizes high-efficiency sterilization and inflammation diminishing effects through the synergistic effect of the ionized bacteriostatic agent and the negative ions, wherein the synergistic effect is superior to the effect which can be achieved by singly using one of the ionized bacteriostatic agent and the negative ions.
The invention provides in a first aspect an aerosol generating system comprising a discharge unit, a fluid unit and a mixing chamber;
the discharging unit comprises a discharging generator, a voltage conveying device and a voltage releasing port which are connected in sequence; the voltage release port is located in the mixing cavity;
the fluid unit comprises a storage device and a fluid flow chamber; a fluid release port is arranged on the storage device, and the side wall of the fluid flow chamber is communicated with the storage device through the fluid release port; one end of the fluid flowing chamber is provided with an air inlet, and the other end of the fluid flowing chamber is communicated with the mixing cavity.
According to some embodiments of the aerosol-generating system of the present invention, the storage device is a gaseous bacteriostatic agent container and/or a liquid bacteriostatic agent container.
In accordance with some embodiments of the aerosol generating system of the present invention, when the storage device is a liquid bacteriostatic agent container, the fluid release port is an atomizer head. The atomizer nozzle can disperse the liquid bacteriostatic agent into tiny liquid drops, and the tiny liquid drops are convenient to be subsequently input into the mixing cavity and ionized.
According to some embodiments of the aerosol generating system of the present invention, when the storage device is a gaseous bacteriostatic agent container, the fluid release port is a gas release port.
According to some embodiments of the aerosol generating system of the present invention, the discharge generator is externally connected to a power source. Preferably, the discharge generator is a corona discharge generator. Further preferably, the corona discharge generator includes a circuit integration box, be provided with anodal power input line and negative pole power input line on the circuit integration box, anodal power input line and negative pole power input line respectively with the power is connected, realizes the circuit intercommunication.
According to some embodiments of the aerosol generating system of the present invention, the voltage delivery device is a high voltage output wire.
According to some embodiments of the aerosol-generating system of the present invention, the mixing chamber is made of a non-conductive material.
In accordance with some embodiments of the aerosol generating system of the present invention, the system further comprises a fluid transport device, the fluid flow chamber and the mixing cavity being in communication via the fluid transport device.
In some embodiments of the aerosol generating system of the present invention, the system further comprises an air pump in communication with the air inlet.
In some embodiments of the aerosol generating system of the present invention, the system further comprises an aerosol spray head disposed on the mixing chamber.
According to a preferred embodiment of the aerosol generating system of the present invention, the air inlet is connected to the fluid flow chamber by a first connector, and the fluid flow chamber is connected to the fluid transport device by a second connector.
After the discharge unit is powered on, the electric field generated by the voltage release port ionizes surrounding gas to generate negative ions, and meanwhile, the discharge unit can be used as an ionization source to ionize fluid input from the fluid flow chamber and mix the fluid in the mixing cavity, so that mixed aerosol of the ionized fluid and the negative ions is obtained.
In a specific embodiment of the invention, a corona discharge generator is used as the discharge generator, and the fluid is a liquid bacteriostatic agent and/or a gaseous bacteriostatic agent. In this embodiment, the corona discharge generator can also serve as an ion source to ionize the bacteriostatic agent in addition to generating negative ions. Therefore, under the dual function of the corona discharge generator, the ionized bacteriostatic agent and the negative ions can be simultaneously generated and mixed to form the aerosol. The mixed aerosol has the sterilization effect of the two. In addition, the ionized bacteriostatic agent can obviously improve the efficacy of the bacteriostatic agent, and the principle is as follows: compared with non-charged bacteriostats, ionized bacteriostats can be more easily attached and captured by bacteria due to electrostatic action; ionized bacteriostatic agents tend to form a hydrated layer around them, e.g., molecules encapsulated by the hydrated layer tend to penetrate the outer membrane of gram-negative bacteria (lower phospholipid content) more readily, contacting the inner membrane of the bacteria (i.e., cytoplasmic membrane) and lysing the inner membrane to kill the bacteria, whereas the outer membrane of gram-negative bacteria is a barrier to normal bacteriostatic agents (lipid soluble).
In the invention, the antibacterial processes of the ionized bacteriostatic agent and the negative ions are not performed in isolation, and a synergistic effect exists between the antibacterial processes of the ionized bacteriostatic agent and the negative ions, which is superior to the effect that one of the ionized bacteriostatic agent and the negative ions can play independently, so that higher sterilization efficiency can be realized by using a smaller dose of bacteriostatic agent. In various embodiments of the present invention, when the aerosol generating system is used for treating inflammation, the aerosol generating system has high sterilization efficiency, and the usage amount of the bacteriostatic agent is further saved, so that the cost is saved, and the toxicity harm brought by the bacteriostatic agent is reduced.
In a second aspect, the present invention provides a method of aerosol generation in accordance with the aerosol generation system described above, the method comprising the steps of:
step A, activating the fluid release port to release fluid, wherein the fluid is sent into the fluid flow chamber through the side wall of the fluid flow chamber;
b, gas is fed into the fluid flow chamber from the gas inlet, and the gas carries the fluid into the mixing cavity;
and step C, starting the discharge generator, wherein the voltage release port generates an electric field in the mixing cavity.
According to some embodiments of the method of the present invention, the fluid is a gaseous bacteriostatic agent and/or a liquid bacteriostatic agent. In various embodiments of the present invention, the types of the gaseous bacteriostatic agent and the liquid bacteriostatic agent are not limited, and different gaseous bacteriostatic agents and liquid bacteriostatic agents can be selected according to different pathogenic bacteria.
According to some embodiments of the method of the present invention, when liquid bacteriostatic agent is selected, the fluid delivery port is preferably an atomizer head, such that the liquid bacteriostatic agent disperses into tiny droplets for subsequent introduction into the mixing chamber and ionization.
According to some embodiments of the method of the present invention, the gaseous bacteriostatic agent is preferably ozone and/or a volatile essential oil. The liquid bacteriostatic agent is preferably ethanol and/or quaternary ammonium salt.
In different embodiments of the present invention, different bacteriostatic agents may be selected according to different bacteriostatic purposes. For example, the alcohol organic bacteriostatic agent such as ethanol in the invention can remove lipid substances in the biofilm of pathogenic bacteria and denature proteins, wherein the most commonly used alcohol organic bacteriostatic agent is ethanol with the mass concentration of 75%. Moreover, the quaternary ammonium salt bacteriostatic agent can adsorb pathogenic bacteria microorganisms with negative charges, destroy cell wall structures of the microorganisms, and cause contents in the microorganisms to leak, and meanwhile, the quaternary ammonium salt bacteriostatic agent also has the effects of inhibiting activities of pathogenic bacteria oxidase, dehydrogenase and the like.
According to some embodiments of the method of the present invention, the gas is oxygen and/or nitrogen. Preferably, the gas is a mixed gas of oxygen and nitrogen. Further preferably, the volume ratio of oxygen in the mixed gas of oxygen and nitrogen is 28%. In some embodiments of the present invention, the type of gas introduced is not limited, and the gas may be air for cost and realizability.
According to some embodiments of the method of the present invention, the mixing cavity is made of a non-conductive material, so that an electric field generated when the voltage release port discharges can be prevented from being conducted through the mixing cavity. Preferably, the preparation material of the mixing cavity is selected from at least one of polyvinyl fluoride, nylon and organic glass.
According to some embodiments of the method of the present invention, the electric field local strength is ≧ 20 kV/cm. In various embodiments of the present invention, the input voltage of the discharge generator is not limited because the electric field is a non-uniform electric field as long as the local strength of the electric field is more than or equal to 20 kV/cm.
In the invention, after being input into the air inlet by the air pump, the air enters the fluid flow chamber through the air inlet, and the air carries the fluid therein to enter the mixing cavity. In the mixing cavity, after the discharge generator is started, a voltage release port at the tail end releases a strong electric field in the mixing cavity to ionize the surrounding gas to generate negative ions, and meanwhile, the strong electric field can also be used as an ionization source to ionize fluid in the mixing cavity, so that mixed aerosol of the ionized fluid and the negative ions is obtained.
In a particular embodiment of the invention, the fluid is selected to be a gaseous bacteriostatic agent and/or a liquid bacteriostatic agent, such that the method has bactericidal and anti-inflammatory effects. The mixed aerosol obtained in the embodiment is an ionized bacteriostatic agent and negative ion mixed aerosol, and has high-efficiency sterilization and anti-inflammation capabilities.
In the invention, the discharge generator adopts a corona discharge generator. After the corona discharge generator is powered on, a voltage release port at the tail end of the corona discharge generator generates a strong electric field to ionize nearby gas, wherein the gas can be air or high-purity gas input by a gas pump, or mixed gas of the air and at least one high-purity gas.
The specific ionization process is as follows: the strong electric field of the voltage release port can cause free electrons in the air to violently collide with oxygen molecules to generate oxygen free radicals-And superoxide radical. O2 -The reaction process is shown as formula (1) and formula (2):
e+O2＝·O-+O (1)
·O-+O2＝·O2 -+O (2)
oxygen radical O-And superoxide radical. O2 -Can continue to react with NO in the air2And CO2Reaction to produce NO3 -、HCO3 -、CO3 -And CO4 -. In addition, the negative ions generated by this process attract the positive polarity ends of free water molecules (i.e., hydrogen atoms) in the air to form hydrates, such as: CO 23 -·H2O、HCO3 -·H2O、NO3 -·H2O and CO4 -·H2And O. For convenience of description, n is used in the present invention-Denotes the general term of the negative ion, i.e. n-Is O-、·O2 -、NO3 -、CO3 -、HCO3 -、CO4 -、CO3 -·H2O、HCO3 -·H2O、NO3 -·H2O and CO4 -·H2And O and other negative ions.
The process of ionizing bacteriostatic agent molecules (M) by a corona generator is shown as formula (3):
e+M＝M- (3)
non-energetic free electrons are captured by bacteriostatic molecules to form ions M-. Also, M-Hydrates M may also be formed-·H2O。
According to some embodiments of the methods of the invention, there is provided n of the invention-And M-·H2The aerosol formed by the O mixture can permeate the cell outer membrane of gram-negative bacteria to reach the cell inner membrane of the bacteria. Specifically, the antibacterial mechanism of the mixed aerosol is as follows: (1) acting on protease or other bioactive substances required by biochemical reaction. (2) Acting on the genetic material DNA or other genetic microparticulate structure. (3) Acting on the biological membrane system or cell wall. The kind of bacteria is not limited in the present invention, and in different embodiments of the present invention, different bacteriostatic agents may be specifically selected for different types of bacteria species.
The ionized bacteriostatic agent can also have the antibacterial effect of negative ions.
In some embodiments of the invention, the antibacterial mechanism of the negative ion against gram-positive bacteria is as follows:
Figure BDA0002874781730000051
first, the negative ions tend to attack the carbonyl groups on the tetrapeptide chains and pentaglycine bridges, which constitute the main framework of the cell wall of pathogenic bacteria, as in the processes shown in equations (4) and (5). In the course of the reaction, the anion n-The process of reaction formula (5) occurs by nucleophilic addition interacting with C ═ O bonds to form tetrahedral intermediates, i.e. the product of reaction formula (4), which then decompose and cleave peptide bonds.
The pathogenic bacterial cell wall skeleton is then broken, leaving only the glycan skeleton, which means that the pathogenic bacterial protective layer has been destroyed, making the cell more fragile. Then, the negative ion n-Further attack on the inner cell membrane by cell translocation. Subsequently, the reaction between the negative ion and the cell membrane also occurs on the phospholipid molecule. Among them, phospholipid molecules are essential components for stabilizing the membrane structure. Reaction of formula (6), anion n, occurs by nucleophilic addition-Attack of the O group results in the loss of the ester bond, and reaction (7) occurs.
At the same time, the negative ion n-It is also easy to attack the phosphate bond P ═ O on intracellular membrane phospholipids, resulting in reaction formula (8), and after its adduct, the backbone is decomposed, resulting in reaction formula (9).
Figure BDA0002874781730000061
Figure BDA0002874781730000062
In the invention, the antibacterial processes of the ionized bacteriostatic agent and the negative ions are not performed in isolation, and a synergistic effect exists between the antibacterial processes of the ionized bacteriostatic agent and the negative ions, which is superior to the effect that one of the ionized bacteriostatic agent and the negative ions can independently play. In various embodiments of the present invention, when the aerosol generating method is used for treating inflammation, the aerosol generating method has high sterilization efficiency, and the usage amount of the bacteriostatic agent is further saved, so that the cost is saved, and the toxicity harm brought by the bacteriostatic agent is reduced.
According to a third aspect of the invention, there is provided an apparatus for the treatment of inflammation, the apparatus comprising an aerosol generating system as defined above.
In accordance with some embodiments of the inflammation therapy device of the present invention, the device further comprises a cleaning device having a cleaning fluid inlet, a cleaning fluid flow passage, and a cleaning fluid spray head.
According to some embodiments of the inflammation therapy apparatus of the present invention, the apparatus further comprises a drying device having a dry gas inlet, a dry gas flow channel, and a dry gas spray head.
According to the invention, the cleaning device and the drying device can be used for cleaning and drying the affected part before and after treatment, so that the anti-inflammatory and bactericidal effects can be better ensured, and the probability of infection recurrence is reduced.
In accordance with some embodiments of the inflammation therapy apparatus of the present invention, the apparatus further comprises a control device comprising a motor, a rotating screw, and a translation stage. Wherein the aerosol spray head, the cleaning liquid spray head and the dry air spray head are arranged on the translation carrying platform. The motor is electrically connected with the rotating screw and used for controlling the rotating screw to rotate, the rotating screw is used for controlling the translation stage to translate, and the translation stage is used for switching the aerosol spray head, the cleaning liquid spray head and the dry air spray head to work.
In accordance with some embodiments of the inflammation therapy apparatus of the present invention, the control device further comprises a frame for holding the motor, the rotating screw, and the translation stage.
The type of the control device is not limited in the invention, for example, the control device in the invention is an electric control translation stage, and the electric control translation stage can be manufactured by self according to requirements and can also be purchased from existing products of manufacturers. For example, the electrically controlled translation stage may be purchased from FUYU, electrically controlled linear rail slide, available from yokoyu technologies, inc, with the specific model FSL 80.
According to some embodiments of the inflammation therapy apparatus of the present invention, the apparatus further comprises an assembly cavity, the aerosol generating system, the cleaning device, the drying device and the control device are disposed in the assembly cavity, one end of the assembly cavity is open, and the translation stage is disposed right below the opening.
According to the inflammation therapeutic apparatus provided by the invention, the aerosol generating system generates mixed aerosol of ionized bacteriostatic agent and negative ions to treat inflammation on the affected part, and the aerosol nozzle, the cleaning liquid nozzle and the dry air nozzle on the translation carrying platform are switched to work in turn by rotating the rotary screw rod in the control device, so that the functions of sterilization, inflammation diminishing, cleaning and drying are respectively realized.
In the specific embodiment of the invention, if there is an unclean object at the inflammation affected part, the cleaning device can be switched to first to clean the affected part, then the drying device is switched to dry, and the drying treatment process is carried out after each cleaning action is finished, then the aerosol spray head is switched to sterilize and diminish inflammation of the affected part, then the cleaning and drying treatment are carried out, and the cleaning and drying treatment process is carried out after each sterilizing and diminishing inflammation action, so that the high sterilizing and diminishing efficiency is realized, the using amount of the bacteriostatic agent is saved, the toxic hazard brought by the bacteriostatic agent is weakened, the cost is saved, and the recurrent infection with the lowest probability is realized through the cleaning and drying treatment processes.
According to a fourth aspect of the present invention, there is provided the use of an aerosol generating system according to the above, an inflammation treatment apparatus according to the above, or a method of generating an aerosol according to the above, in a topical inflammation treatment apparatus, preferably in a gynaecological inflammation treatment apparatus and/or a haemorrhoidal anal inflammation treatment apparatus. But is not limited thereto.
The invention has the beneficial effects that:
1. the antibacterial process of the mixed aerosol of the ionized bacteriostatic agent and the negative ions is not performed independently, and the antibacterial process of the ionized bacteriostatic agent and the negative ions has a synergistic effect, so that the synergistic effect is better than the effect of one of the ionized bacteriostatic agent and the negative ions when the one of the ionized bacteriostatic agent and the negative ions is used alone, and a wider antibacterial effect can be realized.
2. When the mixed aerosol of the ionized bacteriostatic agent and the negative ions provided by the invention is used for treating inflammation, the mixed aerosol has higher sterilizing efficiency, and the using amount of the bacteriostatic agent is further saved, so that the cost is saved, and the toxicity harm brought by the bacteriostatic agent is weakened.
3. The inflammation therapeutic apparatus provided by the invention adopts the aerosol generation system, the cleaning device and the drying device to carry out comprehensive treatment on the affected part, and can realize the lowest probability of recurrent infection.
Drawings
Fig. 1 is a schematic structural diagram of an aerosol generating system according to embodiment 1 of the present invention.
Fig. 2 is a schematic structural diagram of an aerosol generating system according to embodiment 2 of the present invention.
Fig. 3 is a schematic structural diagram of an aerosol generating system according to embodiment 3 of the present invention.
Fig. 4 is a schematic structural diagram of an inflammation therapy apparatus according to embodiment 4 of the present invention.
Fig. 5 is a schematic structural diagram of a control device, a cleaning device, a drying device and a circuit device in the inflammation therapeutic apparatus according to embodiment 4 of the present invention.
Description of reference numerals:
1. the device comprises an assembly cavity, 2, a control device, 3, an aerosol generating system, 4, a cleaning device, 5, a drying device and 6, a circuit device;
201. a motor 202, a rotating screw 203, a frame 204 and a translation carrier;
311. positive power input line, 312, negative power input line, 313, circuit integrated box, 314, high voltage output wire, 315, voltage release port;
321. an air inlet, 322, a first interface, 323, a fluid flow chamber, 324, a second interface, 325, a fluid delivery device, 326, a mixing chamber, 327, an aerosol spray head;
331. liquid bacteriostatic agent container, 332, atomizer spray head;
341. a gaseous bacteriostatic agent container 342, a gas release port;
401. a cleaning liquid inlet 402, a third interface 403, a cleaning liquid flow passage 404, a fourth interface 405, a cleaning liquid spray head;
501. a dry gas inlet 502, a fifth interface 503, a dry gas channel 504, a sixth interface 505, a dry gas spray head;
601. power adapter, 602, wire.
Detailed Description
In order that the invention may be more readily understood, reference will now be made in detail to the accompanying drawings and examples, which are given by way of illustration only and are not intended to limit the scope of the invention.
The equipment used in the invention is as follows:
(1) the electric control translation table is a FUYU electric numerical control linear guide rail sliding table of Chengdu Fuyu science and technology limited company, and the model is FSL 80.
(2) The corona discharge generator is the product in CN 201710285159.6.
[ example 1 ]
As shown in fig. 1, a schematic structural diagram of an aerosol generating system provided in this embodiment includes a discharge unit, a fluid unit, and a mixing cavity 326. Wherein the mixing chamber 326 is made of teflon.
The discharge unit includes a positive power input line 311, a negative power input line 312, a circuit integration box 313, a high voltage output wire 314, and a voltage release port 315. The positive power input line 311 and the negative power input line 312 are provided on the circuit integration box 313 for external power supply. The circuit integration box 313 and the voltage release port 315 are connected by a high voltage output wire 314. The voltage discharge port 315 is located in the mixing cavity 326 and is used for discharging a strong electric field after being energized and ionizing air and other gases therein to generate negative ions.
The fluid unit includes a liquid bacteriostatic agent container 331, a gaseous bacteriostatic agent container 341, and a fluid flow chamber 323. The liquid bacteriostatic agent container 331 is provided with an atomizer 332 for dispersing the liquid bacteriostatic agent into tiny droplets. The gaseous bacteriostatic agent container 341 is provided with a gas release port 342. The side wall of the fluid flow chamber 323 communicates with the liquid bacteriostatic agent container 331 and the gaseous bacteriostatic agent container 341 through the atomizer head 332 and the gas discharge port 342, respectively. Also, one end of the fluid flow chamber 323 is provided with an air inlet 321, and the other end communicates with the mixing chamber 326 via a fluid transfer device 325. The air inlet 321 is externally connected to an air pump (not shown), the air inlet 321 is connected to the fluid flow chamber 323 through a first joint 322, and the fluid flow chamber 323 is connected to the fluid delivery device 325 through a second joint 324.
The atomized liquid bacteriostatic agent sprayed from the liquid bacteriostatic agent container 331 and the gaseous bacteriostatic agent sprayed from the gaseous bacteriostatic agent container 341 are input into the mixing cavity 326 through the fluid conveying device 325, and are ionized under the action of the strong electric field released from the voltage release port 315 to obtain an ionized bacteriostatic agent, so as to generate a mixed aerosol with negative ions. The mixed aerosol is sprayed out through the aerosol nozzle 327 to sterilize and diminish inflammation of the affected part.
[ example 2 ]
As shown in fig. 2, the present embodiment has the same structure as the aerosol generating system of embodiment 1, except that: in this embodiment, the liquid bacteriostatic agent container 331 and the atomizer head 332 are not provided.
[ example 3 ]
As shown in fig. 3, the present embodiment has the same structure as the aerosol generating system of embodiment 1, except that: in this embodiment, the gaseous bacteriostatic agent container 341 and the gas release port 342 are not provided.
[ example 4 ]
As shown in fig. 4, a schematic structural diagram of an inflammation therapeutic apparatus provided in this embodiment includes an assembly cavity 1, a control device 2, an aerosol generating system 3, a cleaning device 4, a drying device 5, and a circuit device 6. The structure of the aerosol generating system is the same as that described in embodiment 1, and is not described herein.
As shown in fig. 5, the cleaning device 4 includes a cleaning liquid inlet 401, a cleaning liquid flow passage 403, and a cleaning liquid ejection head 405, wherein the cleaning liquid inlet 401 and the cleaning liquid flow passage 403 are connected by a third interface 402, and the cleaning liquid flow passage 403 and the cleaning liquid ejection head 405 are connected by a fourth interface 404.
The drying device 5 has a drying air inlet 501, a drying air flow channel 503 and a drying air nozzle 505, wherein the drying air inlet 501 and the drying air flow channel 503 are connected by a fifth interface 502, and the drying air flow channel 503 and the drying air nozzle 505 are connected by a sixth interface 504.
The control device 2 in this embodiment selects an electric control translation stage, where the electric control translation stage includes a motor 201, a rotating screw 202, a frame 203, and a translation stage 204. Frame 203 is used to hold motor 201, rotating screw 202, and translation stage 204. The translation stage 204 is provided with an aerosol spray head 327, a cleaning liquid spray head 405 and a dry gas spray head 505. The motor 201 is electrically connected with the rotating screw 202 and is used for controlling the rotating screw 202 to rotate, and the rotating screw further controls the translation carrying platform 204 to translate, so that the aerosol spray head 327, the cleaning liquid spray head 405 and the dry air spray head 505 are switched to work in turn.
The circuit arrangement 6 comprises a power adapter 601 and a cord 602 connected thereto for providing power to the inflammation therapy device.
As shown in fig. 4, the aerosol-generating system 3, the cleaning device 4, the drying device 5, the control device 2 and the circuit device 6 are all disposed in the assembly chamber 1. Moreover, one end of the assembly cavity 1 is opened, and the translation carrying table 204 is positioned right below the opening, so that the materials in the aerosol spray head 327, the cleaning liquid spray head 405 and the dry gas spray head 505 can be sprayed to the affected part.
[ example 5 ]
This example provides an aerosol generating system of example 1 for use in a gram negative bacteria sterilization process, comprising the steps of:
step A, adopting a liquid ethanol bacteriostatic agent with the mass concentration of 75%, spraying atomized ethanol from an atomizer nozzle 332, and feeding the atomized ethanol into a fluid flow chamber 323.
And step B, feeding mixed gas of oxygen and nitrogen with the volume ratio of 28% into the fluid flow chamber 323 through the air inlet 321 by the air pump, and carrying atomized ethanol into the mixing cavity 326.
And step C, switching on the circuit integration box 313, and generating a corona-starting electric field with the local electric field intensity of 20kV/cm in the mixing cavity 326 by the voltage release port 315.
Under the action of the strong electric field, the atomized ethanol is subjected to ionization reaction to obtain ionized ethanol, and oxygen is subjected to negative ion reaction to obtain oxygen radical O-And superoxide radical. O2 -The negative ions are mixed in the mixing cavity 326 to obtain a mixed aerosol. The mixed aerosol is used to treat pathogens.
In conclusion, the aerosol generation system and the inflammation therapeutic apparatus provided by the invention have high-efficiency sterilization and inflammation diminishing effects, can effectively solve the problem of improvement of drug resistance of pathogenic bacteria due to wide use of bacteriostatic agents, have wider bacteriostatic effects, have less reagent consumption and lower cost, can weaken the toxic hazard of the bacteriostatic agents, and obviously reduce the probability of recurrent infection.
What has been described above is merely a preferred example of the present invention. It should be noted that other equivalent variations and modifications can be made by those skilled in the art based on the technical teaching provided by the present invention, and the protection scope of the present invention should be considered.

Claims (10)

1. An aerosol generating system, comprising a discharge unit, a fluid unit, and a mixing chamber;
the discharging unit comprises a discharging generator, a voltage conveying device and a voltage releasing port which are connected in sequence; the voltage relief port is located within the hybrid cavity;
the fluid unit comprises a storage device and a fluid flow chamber; a fluid release port is arranged on the storage device, and the side wall of the fluid flow chamber is communicated with the storage device through the fluid release port; one end of the fluid flowing chamber is provided with an air inlet, and the other end of the fluid flowing chamber is communicated with the mixing cavity.
2. An aerosol generating system according to claim 1, wherein the storage means is a gaseous bacteriostatic agent container and/or a liquid bacteriostatic agent container; preferably, the fluid release port is an atomizer head; and/or the presence of a gas in the gas,
the discharge generator is externally connected with a power supply; preferably, the discharge generator is a corona discharge generator; preferably, the voltage transmission device is a high-voltage output wire; and/or the presence of a gas in the gas,
the mixing chamber is made of a non-conductive material.
3. An aerosol generating system according to claim 1 or 2, further comprising a fluid transport device, wherein the fluid flow chamber is in communication with the mixing chamber via the fluid transport device; and/or the presence of a gas in the gas,
the system also comprises an air pump which is communicated with the air inlet; and/or the presence of a gas in the gas,
the system also comprises an aerosol spray head, and the aerosol spray head is arranged on the mixing cavity; and/or the presence of a gas in the gas,
the air inlet is connected with the fluid flow chamber through a first joint, and the fluid flow chamber is connected with the fluid conveying device through a second joint.
4. A method of aerosol generation by an aerosol generating system according to any of claims 1 to 3, comprising the steps of:
step A, activating the fluid release port to release fluid, wherein the fluid is sent into the fluid flow chamber through the side wall of the fluid flow chamber;
b, gas is fed into the fluid flow chamber from the gas inlet, and the gas carries the fluid into the mixing cavity;
and step C, starting the discharge generator, wherein the voltage release port generates an electric field in the mixing cavity.
5. The aerosol generating method of claim 4, wherein the fluid is a gaseous bacteriostatic agent and/or a liquid bacteriostatic agent; preferably, the gaseous bacteriostatic agent is ozone and/or volatile essential oil; preferably, the liquid bacteriostatic agent is ethanol and/or quaternary ammonium salt; and/or the presence of a gas in the gas,
the preparation material of the mixing cavity is a non-conductor material, and is preferably at least one of polyvinyl fluoride, nylon and organic glass; and/or the presence of a gas in the gas,
the local strength of the electric field is more than or equal to 20 kV/cm.
6. An inflammation therapy device comprising an aerosol generating system according to any one of claims 1 to 3.
7. The inflammation therapy device of claim 6, further comprising a cleaning device having a cleaning fluid inlet, a cleaning fluid flow path, and a cleaning fluid spray head; and/or the presence of a gas in the gas,
the therapeutic apparatus also comprises a drying device which is provided with a dry air inlet, a dry air flow channel and a dry air nozzle.
8. The inflammation therapy apparatus of claim 7, further comprising a control device, wherein the control device comprises a motor, a rotating screw, and a translation stage; the translation carrying platform is provided with the aerosol spray head, the cleaning liquid spray head and the dry air spray head; the motor is electrically connected with the rotating screw and used for controlling the rotating screw to rotate, the rotating screw is used for controlling the translation stage to translate, and the translation stage is used for switching the aerosol spray head, the cleaning liquid spray head and the dry air spray head to work;
preferably, the control device further comprises a frame for fixing the motor, the rotating screw and the translation stage.
9. The inflammation therapy apparatus according to claim 8, further comprising an assembly chamber, wherein the aerosol generating system, the cleaning device, the drying device and the control device are disposed in the assembly chamber, one end of the assembly chamber is open, and the translation stage is disposed directly below the opening.
10. Use of an aerosol generating system according to any one of claims 1 to 3, of an aerosol generating method according to claim 4 or 5 or of an inflammation therapeutic apparatus according to any one of claims 6 to 9 in a topical inflammation therapeutic apparatus, preferably in a gynaecological inflammation therapeutic apparatus and/or a haemorrhoidal anal inflammation therapeutic apparatus.
CN202011611669.6A 2020-12-30 2020-12-30 Aerosol generating system, aerosol generating method, inflammation therapeutic apparatus and application thereof Pending CN112742313A (en)

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Application Number Priority Date Filing Date Title
CN202011611669.6A CN112742313A (en) 2020-12-30 2020-12-30 Aerosol generating system, aerosol generating method, inflammation therapeutic apparatus and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202011611669.6A CN112742313A (en) 2020-12-30 2020-12-30 Aerosol generating system, aerosol generating method, inflammation therapeutic apparatus and application thereof

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CN112742313A true CN112742313A (en) 2021-05-04

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