CN112716643A - Regional function specificity clinical periodontal defect repair module - Google Patents
Regional function specificity clinical periodontal defect repair module Download PDFInfo
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
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Abstract
The invention provides a regional function specificity clinical periodontal defect repair module which is integrated by an alveolar bone regeneration functional domain, a periodontal ligament regeneration functional domain and a barrier ligament functional domain. The alveolar bone regeneration functional domain is designed and manufactured in an individualized way based on the bone defect shape of a patient with periodontitis, is matched with the defect shape, and can construct a stable bone defect repair space; the periodontal ligament regeneration functional domain is designed and prepared by using a simulated periodontal fiber guide structure, so that more favorable local conditions are provided for periodontal ligament regeneration; the barrier membrane functional domain and the alveolar bone regeneration functional domain are integrated, so that epithelial cells can be prevented from growing into the defect, the operation is simplified, and the sensitivity of the regeneration operation technology is reduced. The novel periodontal regeneration operation based on the periodontal defect repair module can improve the certainty of periodontal tissue regeneration, reduce the technical sensitivity of the periodontal regeneration operation and provide more possibility for preserving the affected teeth of periodontitis.
Description
Technical Field
The invention belongs to a repair material of periodontal tissues, and relates to a clinical periodontal defect repair module with regional function specificity.
Background
Periodontitis is one of the most common oral diseases, and can cause progressive irreversible destruction of periodontal supporting tissues such as gingiva, alveolar bone, periodontal ligament and cementum, resulting in swelling and bleeding of gingiva, recession of gingiva, resorption of alveolar bone, loose and displaced teeth, and even tooth loss. At present, periodontitis has become the leading and leading cause of tooth loss in our country and even in adults worldwide. The ideal periodontitis treatment not only removes the etiology and risk factors to eliminate inflammation and control disease development; more important is the repair and reconstruction of the destroyed periodontal tissue structure, i.e. the regeneration of the periodontal tissue. Periodontal tissue regeneration is the necessary way to achieve the real cure of periodontitis.
The combined use of Guided Tissue Regeneration (GTR) and periodontal bone grafting is currently the most common means of periodontal regeneration. A great deal of research has proved that the two types of operation are jointly applied to the regeneration and repair effect in the II-wall, III-wall and II-degree root bifurcation lesions and other involved bone defects. When treating non-contained bone defects with poor accommodation degree of bone substitute materials, the two types of surgery have poor curative effects, and the key problem is that a stable bone defect repair space is difficult to create and maintain.
The principle of GTR is to use membranous material as a barrier to prevent gingival epithelial cells and connective tissue cells from growing to the root surface, form a certain repair space under the membrane, induce periodontal membrane cells with periodontal tissue regeneration potential to occupy the root surface, and form new alveolar bone, periodontal membrane and cementum. In clinical practice, GTR and periodontal bone grafting are often used in combination, that is, after a bone substitute material is implanted into a defect area, a barrier film with a suitable shape is trimmed and covered on the surface of the implant material, and the implant material can support the barrier film and stabilize a bone repair space. However, periodontal bone defects are complex and various, and it is difficult for a doctor to completely conform the barrier membrane trimmed by hands to the bone defect shape; while the barrier membrane is susceptible to collapse or displacement during the surgical procedure and post-healing. The dressing and shaping of the barrier membrane in the operation will increase the sensitivity of the regenerative operation technique, prolong the operation time and increase the pain of the patient. The post-operative barrier membrane displacement and collapse can in turn affect the post-operative healing effects of periodontal regeneration.
After periodontal regeneration, cells from four sources, namely gingival epithelium, gingival connective tissue, periodontal ligament and alveolar bone, are attached to the root surface first, and four healing fates correspondingly occur, wherein the final healing mode depends on the growth speed and conditions of the cells. Generally, the epithelium grows fastest, first occupying the root surface, forming long-junction epithelial healing. The most ideal healing method is that periodontal ligament cells preferentially occupy the root surface and form periodontal ligament fibers with both ends respectively embedded in the root surface cementum and the new alveolar bone. Periodontal ligament cells grow slower than epithelium, and only periodontal ligament cells near the bottom of the pocket preferentially occupy the root surface, so the chance of healing is rare, and long-term combined epithelial healing remains the most common form of healing after periodontal surgery. However, healing of long-term associated epithelium does not allow periodontal tissues to withstand the physiological function of external force applied by mastication in all directions, and its long-term stability is insufficient, and when it is stimulated by repeated inflammation, it is very likely to cause the repaired periodontal tissues to be destroyed again. The realization of the joint regeneration of periodontal ligament and alveolar bone in periodontal defect is still a clinical bottleneck to be broken through. Therefore, we consider that specific induction of periodontal ligament regeneration is performed at the same time as periodontal regeneration surgery, so as to create local conditions favorable for periodontal ligament regeneration, promote the integrated regeneration of periodontal ligament and alveolar bone, and realize optimal tissue healing.
Disclosure of Invention
In view of the clinical problems mentioned in the background, the object of the present invention is to provide a regional function-specific clinical periodontal defect repair module, which is composed of three alveolar bone regeneration domain and barrier membrane domain and periodontal membrane regeneration domain combined therewith, as shown in fig. 1.
The gingival face of alveolar bone regeneration functional domain (alveolar bone regeneration functional domain is implanting defectively back promptly, is close to the surface of gum, see fig. 1 black dotted line) has the barrier membrane functional domain that blocks the growth of gingival epithelial cell to the defective district of alveolar bone, and barrier membrane functional domain combines together with the gingival face of alveolar bone regeneration functional domain, and barrier membrane functional domain edge exceeds alveolar bone regeneration functional domain gingival face edge 2 ~ 3 mm. And a gingival surface pore structure of the alveolar bone regeneration functional domain and the barrier membrane functional domain form a micro-mechanical lock junction.
The alveolar bone regeneration functional region has a periodontal ligament regeneration functional region that promotes periodontal ligament regeneration on the surface of the tooth root (i.e., the surface of the alveolar bone regeneration functional region adjacent to the tooth root, see white dotted line in fig. 1).
The barrier membrane functional domain is pre-formed on the gingival surface of the alveolar bone regeneration functional domain, is matched with the defect form, and can effectively isolate gingival epithelial cells.
The alveolar bone regeneration functional domain is made of magnesium-doped wollastonite (6% Mg-dopedwolstonite, CSi-Mg6) with magnesium replacing calcium molar ratio of about 6%, the periodontal membrane regeneration functional domain is made of modified Polycaprolactone (PCL)/gelatin electrospun membrane modified by micro-nano-grade bioglass (MNBG), and the barrier membrane functional domain is made of silanized hydroxypropyl methylcellulose (Si-HPMC)/carboxymethyl chitosan methacrylate (MA-CMCS) hydrogel barrier membrane which is formed by photocuring in a mold.
The alveolar bone regeneration functional domain provides mechanical support for the barrier membrane functional domain, and the barrier membrane functional domain is prevented from collapsing into the defect.
The form of the alveolar bone regeneration functional domain is matched with the alveolar bone defect of a clinical patient, and the thickness of the periodontal ligament regeneration functional domain is 1-2 mm; the thickness of the barrier film functional domain is 1.5-2.5 mm.
The periodontal membrane regeneration functional domain is combined with the alveolar bone regeneration functional domain root surface pore structure in a melting mode, the barrier membrane functional domain is combined with the alveolar bone regeneration functional domain gingival surface pore structure in a micro-mechanical locking mode, and the combination is formed when the hydrogel barrier membrane is subjected to photocuring forming.
The invention relates to a preparation method of a regional function specificity clinical periodontal defect repair module, which is realized by the following preparation steps:
designing and manufacturing (3D printing) an alveolar bone regeneration functional domain matched with the shape of a bone defect based on bone defect morphological data of a periodontitis patient, preparing a periodontal membrane regeneration functional domain with a simulated periodontal fiber guide structure by using an improved electrospinning technology on the basis, fusing and combining the periodontal membrane regeneration functional domain with the alveolar bone regeneration functional domain, and finally integrating a Si-HPMC/MA-CMCS hydrogel barrier membrane formed by photocuring on the alveolar bone regeneration functional domain combined with the periodontal membrane regeneration functional domain in the form of the barrier membrane functional domain to obtain a periodontal defect repair module with regional function specificity.
The periodontal ligament regeneration domain can provide favorable local conditions for periodontal ligament neogenesis.
The barrier membrane functional domain can block epithelial cells from growing into the defect, and provides a stable environment for tissue regeneration in the periodontal defect. The integration of the barrier membrane functional domain and the alveolar bone regeneration functional domain can simplify the operation and reduce the sensitivity of the regeneration operation technology.
The novel periodontal regeneration operation based on the invention can improve the certainty of periodontal tissue regeneration, reduce the technical sensitivity of the periodontal regeneration operation and provide more possibility for preserving the affected teeth of periodontitis.
The module integrating the alveolar bone regeneration functional domain and the barrier membrane functional domain can also be used for repairing jaw defects caused by clinical trauma, cyst and tumor resection.
The alveolar bone regeneration functional domain takes CSi-Mg6 as a raw material and is formed by a 3D printing technology, the alveolar bone regeneration functional domain can effectively fill intraosseous defects, a stable regeneration and repair space is created for non-contained bone defects, and alveolar bone tissue repair and regeneration are promoted. The CSi-Mg6 can be gradually degraded during periodontal regeneration and then replaced by new bone tissue. The alveolar bone regeneration functional domain has controllable pore diameter and porosity, and a through pore structure can play a role in bone guiding.
The alveolar bone regeneration functional area gingival surface (see figure 1 black dotted line) has a barrier membrane functional area that blocks the growth of gingival epithelial cells to the alveolar bone defect area, the barrier membrane functional area with the alveolar bone regeneration functional area gingival surface combines, barrier membrane functional area edge surpasss alveolar bone regeneration functional area gingival surface edge 2 ~ 3 mm.
The pore structure of the gingival face of the alveolar bone regeneration functional domain with the barrier membrane functional domain forms a micromechanical lock knot the barrier membrane functional domain combines in the gingival face of the alveolar bone regeneration functional domain, agrees with the defect form, and the operation of trimming and shaping the barrier membrane in the operation is avoided.
The barrier membrane functional domain can effectively isolate gingival epithelial cells, and after the barrier membrane functional domain is combined with the alveolar bone regeneration functional domain, the barrier membrane functional domain can obtain mechanical support to avoid the postoperative inward collapse of defects.
The periodontal ligament regeneration functional domain is prepared by adopting an improved electrospinning technology, has a periodontal ligament fiber bionic guiding structure, and is combined with a pore structure of a root surface (see a white dotted line in figure 1) of the alveolar bone regeneration functional domain in a melting mode.
The shape of the periodontal ligament regeneration functional domain is consistent with the root surface of the alveolar bone regeneration functional domain and is matched with the root surface of the defect area, so that favorable conditions can be provided for periodontal ligament regeneration, and periodontal tissue complex regeneration is promoted.
Referring to fig. 2, the present invention uses the connection line of the near-far middle contact points of the teeth as the boundary, and respectively designs a lip-buccal area function specificity clinical periodontal defect repair module and a tongue-palate area function specificity clinical periodontal defect repair module according to the anatomical positions of the defects, wherein the lip-buccal area function specificity clinical periodontal defect repair module and the tongue-palate area function specificity clinical periodontal defect repair module are respectively used for repairing the lip-buccal side and the tongue-palate side of the same defect, so as to solve the interference of the adjacent contact points of the teeth when the area function specificity clinical periodontal defect.
The repair module comprises an alveolar bone regeneration functional domain, a periodontal ligament regeneration functional domain and a barrier membrane functional domain, can be implanted integrally after flap turning and debridement in periodontal regeneration, and improves the certainty of periodontal tissue complex regeneration and reduces the sensitivity of periodontal regeneration surgery technology on the basis of repairing alveolar bone defects.
The repair module can also repair jaw defects caused by clinical trauma, cyst and tumor resection, and can be integrally implanted after flap turning and debridement in the operation to guide bone tissue regeneration. Referring to fig. 3, when the repair module guides bone tissue regeneration without involving periodontal tissue regeneration, the repair module may be composed of only the alveolar bone regeneration domain and the barrier membrane domain, which is called a regional function-specific clinical jaw defect repair module.
The invention relates to a regional function specificity clinical periodontal defect repair module, which can avoid the influence of the experience and technology of an operator on periodontal regeneration, and the morphological structure of an implanted module can be accurately designed by computer assistance before an operation, so that the intraosseous defect can be effectively filled, and a stable regeneration repair space can be created for a non-contained bone defect, thereby obviously widening the adaptation diseases of periodontal regeneration operation.
The invention adopts a multifunctional domain integration mode, and the periodontal ligament regeneration functional domain is integrated with the alveolar bone regeneration functional domain, thereby providing favorable conditions for periodontal ligament regeneration and promoting periodontal tissue complex regeneration. Designing the alveolar bone regeneration functional domain according to the preoperative periodontal defect form, and combining the barrier membrane functional domain and the periodontal membrane regeneration functional domain on the basis. The periodontal ligament regeneration functional domain provides more favorable local conditions for periodontal ligament regeneration and promotes regeneration of periodontal tissue complex; the functional domain of the barrier membrane can greatly simplify the periodontal regenerative surgery operation and reduce the sensitivity of the regenerative surgery technology. The novel periodontal regeneration surgery based on the regional function specificity clinical periodontal defect repair module is expected to remarkably improve the prognosis of a serious periodontal attachment loss affected tooth, retain and recover the tissue morphology and physiological function of the affected tooth, and provide more possibility for the preservation of the affected tooth with periodontitis. The integrated module of the alveolar bone regeneration functional domain and the barrier membrane functional domain can also be used for repairing jaw bone defects caused by clinical trauma, cyst and tumor resection.
The invention has the main characteristics that:
1. the operation is simplified, the technical sensitivity is reduced, the design and the manufacture of the repair module are completed before the operation, and the implantation is convenient and quick in the operation.
2. The alveolar bone regeneration functional domain is printed out based on the bone defect data in a 3D mode, so that the intra-osseous defects can be effectively filled, and a regeneration repair space can be constructed for the non-contained bone defects.
3. The protective screen membrane functional domain is preformed on the gingival surface of the alveolar bone regeneration functional domain, so that gingival epithelial cells can be effectively isolated, the edge of the gingival surface of the alveolar bone regeneration functional domain is 2-3 mm higher than that of the gingival surface, the protective screen membrane can perfectly fit with the defect form, and the operations of trimming and shaping the protective screen membrane in the operation are avoided. After the surface pore structures of the barrier membrane functional domain and the alveolar bone regeneration functional domain are combined through micromechanical locking, mechanical support can be obtained, and postoperative collapse towards the inside of the defect is avoided.
4. The periodontal ligament fiber bionic guide structure is prepared by adopting an improved electrostatic spinning technology, a periodontal ligament regeneration functional domain is obtained, and the periodontal ligament regeneration functional domain is combined with the root surface of the alveolar bone regeneration functional domain in a melting mode. The periodontal ligament regeneration functional domain can provide favorable conditions for periodontal ligament regeneration and promote periodontal tissue complex regeneration.
5. The regional function specificity clinical periodontal defect restoration module takes a connecting line of near and far middle contact points of teeth as a boundary, is respectively manufactured into a labial-buccal region function specificity clinical periodontal defect restoration module and a tongue-palatal region function specificity clinical periodontal defect restoration module, and is respectively used for restoring the labial buccal side and the tongue-palatal side of the same defect so as to relieve the interference of adjacent contact points of the teeth when the regional function specificity clinical periodontal defect restoration module is implanted.
6. The integrated module of the alveolar bone regeneration functional domain and the barrier membrane functional domain can also be used for repairing jaw bone defects caused by clinical trauma, cyst and tumor resection.
Drawings
FIG. 1 is a schematic diagram of a longitudinal cross-sectional structure of a regional function-specific clinical periodontal defect repair module. In the figure, the black dotted line of the upper right area of the module is the gingival surface of the alveolar bone regeneration functional area; the white dotted line on the left side of the module is the root surface of the alveolar bone regeneration functional area; 1 is alveolar bone regeneration functional domain; 2 is periodontal ligament regeneration functional domain; and 3 is a barrier membrane functional domain.
FIG. 2 is a schematic diagram of the design of the buccal and palatal side of a regional function-specific clinical periodontal defect repair module. Wherein the arrow at the lower left corner indicates the implantation in-place direction of the labial and buccal module; the arrow at the upper right corner indicates the implantation in-place direction of the tongue and palate side module; 4 is a lip-buccal area function specificity clinical periodontal defect repair module; and 5, a tongue palate side area function specificity clinical periodontal defect repair module.
Fig. 3 is a schematic diagram of a longitudinal section of a regional function-specific clinical jaw defect repair module. The module contains only two functional domains: 1 is alveolar bone regeneration functional domain; 3 is a barrier membrane functional domain; the dotted line at the upper right of the module is the gingival surface of the alveolar bone regeneration functional area.
Fig. 4 is a schematic view of regional function specific clinical periodontal defect repair module to repair periodontal defects. In the figure, A: the inside of the virtual ring is clinical periodontal defect; b: a schematic diagram of a repair module repairing a periodontal defect; 1 is alveolar bone regeneration functional domain; 2 is periodontal ligament regeneration functional domain; 3 is a barrier membrane functional domain; 6 is a dental crown; 7 is a tooth root; 8 is a gum; alveolar bone 9.
Fig. 5 is a schematic diagram of a regional function-specific clinical repair module for a jaw bone defect. Wherein A: the inside of the virtual circle is clinical jaw bone defect; b: the repair module is used for repairing clinical jaw defects; 1 is alveolar bone regeneration functional domain; 3 is a barrier membrane functional domain; 8 is a gum; alveolar bone (jaw bone) 9.
Detailed Description
The invention is further explained by the accompanying drawings and examples.
Example 1
Referring to fig. 1, the present invention provides a regional function specific clinical periodontal defect repair module, which is composed of an alveolar bone regeneration domain 1, a periodontal ligament regeneration domain 2 and a barrier membrane domain 3.
The alveolar bone regeneration functional domain 1 is designed according to the shape of periodontal bone defect of a patient, takes degradable bone repair material CSi-Mg6 as a raw material, and is formed by a photocuring 3D printing technology. The alveolar bone regeneration functional domain 1 can effectively plug intraosseous defects, create stable regeneration and repair space for non-contained bone defects, and promote alveolar bone tissue repair and regeneration. The alveolar bone regeneration functional domain has certain pore diameter and porosity, and the through pore structure can play a role in bone guiding. The bone repair material CSi-Mg6 is gradually degraded during periodontal regeneration and then replaced by new bone tissue.
The gingival face of alveolar bone regeneration functional domain 1 (the surface that alveolar bone regeneration functional domain is close to the gum promptly, and the black dotted line indicates the region in figure 1) has the barrier membrane functional domain 3 that blocks the growth of gingival epithelial cell to the defective district of alveolar bone, and 3 edges of barrier membrane functional domain exceed alveolar bone regeneration functional domain gingival face edge 2 ~ 3mm, with the gingival face pore structure of alveolar bone regeneration functional domain forms the micro-mechanical lock knot. The functional area of the barrier membrane is combined with the gingival surface of the regeneration functional area of the alveolar bone and is matched with the defect shape, so that the operations of trimming and shaping the barrier membrane in the operation are avoided. The barrier membrane functional domain is formed by Si-HPMC/MA-CMCS photocuring hydrogel, and can effectively isolate gingival epithelial cells; after being combined with the alveolar bone regeneration functional domain, the barrier membrane functional domain can obtain mechanical support, and the postoperative collapse to the defect is avoided.
The alveolar bone regeneration functional region has a periodontal ligament regeneration functional region 2 on the root surface (i.e., the surface of the alveolar bone regeneration functional region adjacent to the root, which is indicated by a white dotted line in fig. 1) for promoting periodontal ligament regeneration on the root surface. The periodontal ligament regeneration functional domain 2 is prepared by adopting an improved electrostatic spinning technology, has a periodontal ligament fiber bionic guide structure, can provide favorable conditions for periodontal ligament regeneration, and promotes regeneration of periodontal tissue complex. The shape of the periodontal ligament regeneration functional domain is consistent with the root surface of the alveolar bone regeneration functional domain, is matched with the root surface of the defect area, and is combined with the root surface pore structure of the alveolar bone regeneration functional domain in a melting mode.
Referring to fig. 2, the invention designs and manufactures a lip-buccal area function specificity clinical periodontal defect repair module and a tongue-palate area function specificity clinical periodontal defect repair module respectively according to the anatomical position of the defect by taking the connection line of the near-far middle contact points of the teeth as a boundary, and the lip-buccal area function specificity clinical periodontal defect repair module and the tongue-palate area function specificity clinical periodontal defect repair module are respectively used for repairing the lip-buccal side and the tongue-palate side of the same defect so as to solve the interference of the adjacent contact points of the teeth when the area function specificity clinical periodontal defect repair module. The specific clinical periodontal defect repair module of labial-buccal area function and the specific clinical periodontal defect repair module of tongue-palatal area function are all composed of three parts, namely an alveolar bone regeneration functional domain, a periodontal ligament regeneration functional domain and a barrier membrane functional domain, the two are the same repair module, and only different names are adopted due to different repair positions.
Referring to fig. 3, when the present invention only guides bone tissue regeneration and does not relate to periodontal tissue regeneration, the repair module may be composed of only two parts, namely, the alveolar bone regeneration domain 1 and the barrier membrane domain 3, and repairs jaw defects caused by clinical trauma, cyst, and tumor resection, which is called a regional function-specific clinical jaw defect repair module.
Example 2 regional function-specific clinical periodontal defect repair Module preparation
Referring to fig. 4, the present invention can be used to repair periodontal tissue defects as follows:
design of regional function specific clinical periodontal defect repair module
After Cone Beam Computed Tomography (CBCT) data of a patient are exported, three-dimensional reconstruction is carried out on a periodontal defect area, and whether a periodontal defect repair module needs to be applied is judged according to bone defect shapes and soft tissue conditions. Designing the alveolar bone regeneration functional domain 1 according to the defect form and the gum condition on the buccolingual side, namely constructing a printing model with the maximum implantable volume in the operation, and enabling the gum surface of the model to comprise a barrier membrane mold structure with the thickness of 2.5mm and a periodontal membrane regeneration functional domain 2 composite space with the root surface of 1 mm. A through pore structure is designed in an alveolar bone regeneration functional domain by adopting computer model design software, the pore diameter of the model is adjusted to 480 mu m, and the porosity is adjusted to 55%.
Second, preparation of regional function specificity clinical periodontal defect repair module
(1) Preparation of alveolar bone regeneration functional domain
Preparing CSi-Mg6 powder by wet chemical precipitation, taking 30g of CSi-Mg6 powder, and printing an improved alveolar bone regeneration functional domain by adopting a photocuring 3D printing technology.
(2) Preparation of the functional domain of the barrier membrane:
15mL of a photoinitiator-containing MA-CMCS solution 4% (w/v), 7.5mL of a Si-HPMC solution 5% (w/v) and 3.75mL of an acidic buffer solution (containing 0.06M HCl, 1.8% (w/v) NaCl, 6.2% (w/v) 4-hydroxyethylpiperazine ethanesulfonic acid) were mixed to form a mixed solution with a concentration of 4% (w/v). Injecting the prepared mixed solution into a mold containing a hydrogel barrier film on the gingival surface of an alveolar bone regeneration functional region, and irradiating the surface of the gum by using a dental light curing lamp (1200 mw/cm)2420-480nm) to obtain a hydrogel film, and removing the surface mold to obtain a barrier film functional domain.
(3) Preparation of periodontal ligament regeneration domain:
3.0g of PCL, 1.5g of gelatin and 0.5g of bioglass nanoparticles were mixed in a 2,2, 2-trifluoroethanol/glacial acetic acid solvent system to form a 10% homogeneous mixture. Under the conditions of 40 ℃ of temperature and 40% of humidity, a bionic electrospinning membrane with an ordered fiber form is prepared by using a near-field electrostatic spinning technology (15kV, acceptance distance: 15cm) and freeze drying treatment. The root surface of the alveolar bone regeneration functional region is placed at a position 1cm away from a heating plate and heated to 60 ℃, and after 4 seconds, the electrospun membrane is rapidly pressed on the surface of the alveolar bone regeneration functional region and is maintained for 10 seconds. This heating step can melt the surface layer portion of the electrospun membrane, which after cooling and solidification can be firmly combined with the alveolar bone regeneration domain to form the periodontal membrane regeneration domain.
After the preparation and the integration of the alveolar bone regeneration functional domain, the periodontal ligament regeneration functional domain and the barrier ligament functional domain are completed, the clinical periodontal defect repair module with regional function specificity is obtained.
Third, periodontal regenerative surgery based on regional function specificity clinical periodontal defect repair module
(1) The flap-turning debridement is carried out on the periodontal defect area of the patient.
(2) The sterilized regional function specificity clinical periodontal defect repair module is implanted into the defect, the appearance of the repair module is matched with the defect, and good retention can be achieved.
(3) The surgical area is sutured to complete the periodontal regeneration operation.
Example 3
Referring to fig. 5, the present invention can be used for repairing jaw bone defects caused by clinical trauma, cyst, and tumor resection, and comprises the following steps:
regional function specificity clinical jaw defect repair module design
And (3) after the CBCT data of the jaw bone defect patient is derived, three-dimensional reconstruction is carried out on the bone defect area, and whether a bone defect repair module needs to be applied or not is judged according to the bone defect form and the soft tissue condition. Designing an alveolar bone regeneration functional domain according to the defect form and the peripheral soft tissue conditions, namely constructing a printing model with the maximum implantable volume in the operation, and enabling the gingival surface of the model to comprise a barrier membrane mold structure with the thickness of 2.5 mm. A through pore structure is designed in an alveolar bone regeneration functional domain by adopting computer model design software, the pore diameter of the model is adjusted to 480 mu m, and the porosity is adjusted to 55%.
Preparation of regional function specificity clinical jaw defect repair module
(1) Preparation of alveolar bone regeneration functional domain
Preparing CSi-Mg6 powder by wet chemical precipitation, taking 30g of CSi-Mg6 powder, and printing an improved alveolar bone regeneration functional domain by adopting a photocuring 3D printing technology.
(2) Preparation of the functional domain of the barrier membrane:
15mL of a photoinitiator-containing MA-CMCS solution 4% (w/v), 7.5mL of a Si-HPMC solution 5% (w/v) and 3.75mL of an acidic buffer solution (containing 0.06M HCl, 1.8% (w/v) NaCl, 6.2% (w/v) 4-hydroxyethylpiperazine ethanesulfonic acid) were mixed to form a mixed solution with a concentration of 4% (w/v). Injecting the prepared mixed solution into a mold containing a hydrogel barrier film on the gingival surface of an alveolar bone regeneration functional region, and irradiating the surface of the gum by using a dental light curing lamp (1200 mw/cm)2420-480nm) to obtain a hydrogel film, and removing the surface mold to obtain a barrier film functional domain.
After the preparation and integration of the alveolar bone regeneration functional domain and the barrier membrane functional domain are completed, the clinical jaw defect repair module with regional function specificity is obtained.
Third, regenerative surgery based on regional function specificity clinical jaw defect repair module
(1) And (5) performing flap-turning debridement on the bone defect area of the patient.
(2) The sterilized regional function specificity clinical jaw bone defect repairing module is implanted into the defect, the appearance of the repairing module is matched with the defect, and good retention can be achieved.
(3) The operative area is sutured to complete the regenerative surgery.
It is pointed out here that the above description is helpful for the person skilled in the art to understand the invention, but does not limit the scope of protection of the invention. Any such equivalents, modifications and/or omissions as may be made without departing from the spirit and scope of the invention may be resorted to.
Claims (8)
1. A clinical periodontal defect repair module with regional function specificity is characterized in that the module is composed of an alveolar bone regeneration functional domain (1), and a barrier membrane functional domain (3) and a periodontal membrane regeneration functional domain (2) which are combined with the alveolar bone regeneration functional domain.
2. The regional function specific clinical periodontal defect repair module according to claim 1, wherein the gingival surface of the alveolar bone regeneration functional domain (1) has a barrier membrane functional domain (3) for preventing growth of gingival epithelial cells to the alveolar bone defect region, the barrier membrane functional domain (3) is bonded to the gingival surface of the alveolar bone regeneration functional domain (1), the edge of the barrier membrane functional domain (3) exceeds the gingival surface edge of the alveolar bone regeneration functional domain (1) by 2-3 mm, and the root surface of the alveolar bone regeneration functional domain (1) has a periodontal membrane regeneration functional domain (2) for promoting regeneration of periodontal membrane on the root surface.
3. The regional function specific clinical periodontal defect repair module according to claim 1, wherein the gingival pore structure of the alveolar bone regeneration domain (1) forms a micromechanical lock with the barrier membrane domain (3).
4. The regional function specific clinical periodontal defect repair module according to claim 1, wherein the barrier membrane domain (3) is pre-formed on the gingival surface of the alveolar bone regeneration domain (2) to fit the defect shape, and the barrier membrane domain (3) effectively isolates the gingival epithelial cells.
5. The regional function specific clinical periodontal defect repair module according to claim 1, wherein the alveolar bone regeneration domain (1) provides mechanical support for the barrier membrane domain (3) to prevent the barrier membrane domain from collapsing into the defect.
6. The regional function specific clinical periodontal defect repair module according to claim 1, wherein the thickness of the periodontal ligament regeneration functional domain (2) is 1-2 mm; the thickness of the barrier film functional domain (3) is 1.5-2.5 mm.
7. The regional function specific clinical periodontal defect repair module according to claim 1, wherein the periodontal membrane regeneration functional domain (2) and the alveolar bone regeneration functional domain (1) are fused to each other, and the barrier membrane functional domain (3) and the alveolar bone regeneration functional domain (1) are micro-mechanical locked to each other, and the combination is formed when the hydrogel barrier membrane is subjected to photocuring molding.
8. The regional function specificity clinical periodontal defect repair module according to claim 1, wherein the alveolar bone regeneration functional domain (1) is made of magnesium-doped wollastonite with magnesium substituted calcium molar ratio of about 6%, the periodontal film regeneration functional domain (1) is made of modified polycaprolactone/gelatin electrospun film modified by micro-nano-sized bioglass, and the barrier film functional domain (3) is made of silanized hypromellose/carboxymethyl chitosan methacrylate hydrogel barrier film which is formed by photocuring in a mold.
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| WO2022142288A1 (en) * | 2020-12-28 | 2022-07-07 | 浙江大学 | Clinical periodontal defect repair module with regional function specificity |
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| CN115645634B (en) * | 2022-11-08 | 2023-10-17 | 四川大学 | Bone tissue regeneration guiding membrane material, preparation method and application thereof |
| CN116236323B (en) * | 2023-03-17 | 2023-11-17 | 北京大学口腔医学院 | 3D printing alveolar bone grafting structure and preparation method thereof |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3044352A1 (en) * | 1980-11-25 | 1982-06-24 | Johnson & Johnson, 08903 New Brunswick, N.J. | Flocked, foam coated, water vapour permeable, bacterial barrier - from microporous plastic film coated with foamed latex, and flocked fibres |
| JPH03505684A (en) * | 1988-12-23 | 1991-12-12 | グイドール・アクチボラグ | surgical barrier |
| US20020110785A1 (en) * | 1999-11-30 | 2002-08-15 | Arthur Ashman | Method and apparatus for performing ridge augmentation |
| US20070269769A1 (en) * | 2006-05-18 | 2007-11-22 | Marcello Marchesi | Method for the guided regeneration of bone and/or periodontal tissues in the medical surgical and dental field and device thus obtainable |
| KR20080020222A (en) * | 2006-08-31 | 2008-03-05 | 포항공과대학교 산학협력단 | Multilayer film comprising hyaluronic acid derivatives |
| JP2009067732A (en) * | 2007-09-14 | 2009-04-02 | Medgel Corp | Gelatin hydrogel membrane for periodontal surgical treatment |
| US20120045735A1 (en) * | 2010-08-17 | 2012-02-23 | Warsaw Orthopedic, Inc. | Implant repair system and method |
| KR101260757B1 (en) * | 2012-04-30 | 2013-05-06 | 오스템임플란트 주식회사 | Multi-layer absorbable barrier membranes for guiding bone tissue regeneration |
| CN104841021A (en) * | 2015-05-07 | 2015-08-19 | 浙江大学 | Preparation method for chitosan-based biomimetic membrane material with asymmetric structure |
| CN109876192A (en) * | 2019-03-13 | 2019-06-14 | 东华大学 | A kind of Bone Defect Repari film and preparation method thereof |
| CN111330083A (en) * | 2018-12-18 | 2020-06-26 | 诺一迈尔（苏州）医学科技有限公司 | Barrier membrane for guided bone regeneration and preparation method thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5700479A (en) * | 1988-12-23 | 1997-12-23 | Guidor Ab | Surgical element and method for selective tissue regeneration |
| AT403002B (en) * | 1996-05-29 | 1997-10-27 | Mke Metall Kunststoffwaren | FILM OR MEMBRANE FOR COVERING BONE DEFECTS, METHOD FOR PRODUCING THE FILM AND NAIL FOR FIXING THE POSITION OF SUCH A FILM |
| CN201164505Y (en) * | 2008-02-05 | 2008-12-17 | 林辅谊 | Improved structure of article for guiding bone tissue regeneration |
| CN112716643A (en) * | 2020-12-28 | 2021-04-30 | 浙江大学 | Regional function specificity clinical periodontal defect repair module |
-
2020
- 2020-12-28 CN CN202011581712.9A patent/CN112716643A/en active Pending
-
2021
- 2021-07-21 WO PCT/CN2021/107646 patent/WO2022142288A1/en active Application Filing
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3044352A1 (en) * | 1980-11-25 | 1982-06-24 | Johnson & Johnson, 08903 New Brunswick, N.J. | Flocked, foam coated, water vapour permeable, bacterial barrier - from microporous plastic film coated with foamed latex, and flocked fibres |
| JPH03505684A (en) * | 1988-12-23 | 1991-12-12 | グイドール・アクチボラグ | surgical barrier |
| US20020110785A1 (en) * | 1999-11-30 | 2002-08-15 | Arthur Ashman | Method and apparatus for performing ridge augmentation |
| US20070269769A1 (en) * | 2006-05-18 | 2007-11-22 | Marcello Marchesi | Method for the guided regeneration of bone and/or periodontal tissues in the medical surgical and dental field and device thus obtainable |
| KR20080020222A (en) * | 2006-08-31 | 2008-03-05 | 포항공과대학교 산학협력단 | Multilayer film comprising hyaluronic acid derivatives |
| JP2009067732A (en) * | 2007-09-14 | 2009-04-02 | Medgel Corp | Gelatin hydrogel membrane for periodontal surgical treatment |
| US20120045735A1 (en) * | 2010-08-17 | 2012-02-23 | Warsaw Orthopedic, Inc. | Implant repair system and method |
| KR101260757B1 (en) * | 2012-04-30 | 2013-05-06 | 오스템임플란트 주식회사 | Multi-layer absorbable barrier membranes for guiding bone tissue regeneration |
| CN104841021A (en) * | 2015-05-07 | 2015-08-19 | 浙江大学 | Preparation method for chitosan-based biomimetic membrane material with asymmetric structure |
| CN111330083A (en) * | 2018-12-18 | 2020-06-26 | 诺一迈尔（苏州）医学科技有限公司 | Barrier membrane for guided bone regeneration and preparation method thereof |
| CN109876192A (en) * | 2019-03-13 | 2019-06-14 | 东华大学 | A kind of Bone Defect Repari film and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022142288A1 (en) * | 2020-12-28 | 2022-07-07 | 浙江大学 | Clinical periodontal defect repair module with regional function specificity |
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