CN112716443A - Ultrasonic pupil measuring method, ultrasonic host and ultrasonic diagnostic equipment - Google Patents

Ultrasonic pupil measuring method, ultrasonic host and ultrasonic diagnostic equipment Download PDF

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Publication number
CN112716443A
CN112716443A CN201910973501.0A CN201910973501A CN112716443A CN 112716443 A CN112716443 A CN 112716443A CN 201910973501 A CN201910973501 A CN 201910973501A CN 112716443 A CN112716443 A CN 112716443A
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China
Prior art keywords
pupil
ultrasonic
image
light source
source device
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CN201910973501.0A
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Chinese (zh)
Inventor
张茂
凌锋
马青山
罗华
吴春双
刘少云
张仁富
陶林
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Edan Instruments Inc
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Edan Instruments Inc
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Priority to CN201910973501.0A priority Critical patent/CN112716443A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/10Eye inspection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/0008Apparatus for testing the eyes; Instruments for examining the eyes provided with illuminating means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/11Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring interpupillary distance or diameter of pupils
    • A61B3/112Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring interpupillary distance or diameter of pupils for measuring diameter of pupils
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4405Device being mounted on a trolley
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4427Device being portable or laptop-like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4444Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4444Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
    • A61B8/4472Wireless probes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/52Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/5215Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
    • A61B8/5223Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for extracting a diagnostic or physiological parameter from medical diagnostic data

Abstract

The invention provides an ultrasonic pupil measuring method, an ultrasonic host and ultrasonic diagnostic equipment, wherein the method comprises the following steps: when a pupil measurement instruction is received, the ultrasonic probe is controlled to work, and the brightness change of the light source device is controlled, so that a pupil image containing pupil diameter change is obtained; calculating the pupil diameter of the pupil image; and displaying the change curve of the pupil diameter. The ultrasonic pupil measuring method is based on an ultrasonic imaging principle, automatic measurement is carried out without opening the eyelid of a patient, the method is applicable to special scenes such as coma, severe coma and burn, the sensitivity of pupil to light response, including pupil size, pupil shrinkage, pupil reduction rate and the like, is evaluated by controlling the on and off of the light source device and combining the on and off time of the light source device, and important treatment and diagnosis basis is provided for medical clinic.

Description

Ultrasonic pupil measuring method, ultrasonic host and ultrasonic diagnostic equipment
Technical Field
The invention relates to the technical field of medical imaging equipment, in particular to an ultrasonic pupil measuring method, an ultrasonic host and ultrasonic diagnostic equipment.
Background
The size and the change of the diameter of the pupil are important indexes of clinical detection, and the timed and quantitative monitoring of the pupil can reflect physiological arousal, reflect and evaluate autonomic nervous activity, reflect heart rate change and realize the non-contact and non-destructive measurement of heart rate variability; is helpful for the disease judgment of patients with coma, convulsion, shock, poisoning, respiratory failure and circulatory failure, and can judge the intracranial injury part, especially for craniocerebral injury patients. The effective, timely and dynamic observation and evaluation of the pupil change can not only discover the premonitory symptoms of the disease, grasp the best and more treatment opportunities, but also prevent the occurrence of complications, and has important clinical significance, especially in the emergency treatment and the examination and monitoring of an intensive care unit.
In clinic, pupil diameter measurement methods include manual measurement of a doctor, an infrared pupil measuring instrument, a wavefront aberrometer, an ultrasonic biomicroscope and the like, and the pupil measurement methods all require the patient to make a certain posture in cooperation with the doctor and open the eyelid for measurement. However, in clinic, the eye closing conditions, such as coma, severe coma, burn and the like, are inevitably encountered, and the existing measurement method is inconvenient in measurement and can cause secondary damage to the eyes of the patient.
Disclosure of Invention
Therefore, the technical problem to be solved by the present invention is to overcome the defects in the prior art that the pupil measurement is inconvenient in the closed eye condition and secondary damage to the eyes of the patient may be caused, so as to provide an ultrasonic pupil measurement method, an ultrasonic host and an ultrasonic diagnostic apparatus.
The invention provides an ultrasonic pupil measurement method, which comprises the following steps:
when a pupil measurement instruction is received, the ultrasonic probe is controlled to work, and the brightness change of the light source device is controlled, so that a pupil image containing pupil diameter change is obtained;
calculating the pupil diameter of the pupil image;
and displaying the change curve of the pupil diameter.
Optionally, the calculating the pupil diameter of the pupil image and displaying a variation curve of the pupil diameter include:
calculating the pupil diameter of each pupil image according to a preset algorithm;
displaying the variation curve of the pupil diameter based on each pupil image.
Optionally, the calculating the pupil diameter in each pupil image according to a preset algorithm includes:
performing image preprocessing, image segmentation and ellipse fitting on each pupil image to calculate the pupil diameter of one pupil image, wherein the image segmentation comprises one or more of the following modes:
the image segmentation is realized based on an adaptive threshold image segmentation algorithm, the image segmentation is realized based on an energy model image segmentation algorithm, and the image segmentation is realized based on an energy model image segmentation algorithm.
Optionally, the variation curve takes the acquisition time as an abscissa and the pupil diameter as an ordinate.
Optionally, the method further includes: displaying a pupil image containing pupil diameter change, wherein the pupil image and the change curve of the pupil diameter are on the same display interface.
Optionally, the display interface further displays a cursor line for indicating a value corresponding to an abscissa at a certain time, and the cursor line is perpendicular to the abscissa and/or the ordinate.
Optionally, the method further includes: and when the cursor points to a certain moment, displaying the pupil image corresponding to the moment on the display interface.
Optionally, the method further includes:
when a measuring instruction is received, obtaining a measuring diameter according to the two selected points of the pupil image;
and displaying the measured diameter on the display interface.
Optionally, the controlling the operation of the ultrasonic probe and the controlling the light source device to emit light to the tissue to be measured includes:
when the ultrasonic probe works, the light source device is controlled to emit light for a second set time after the set light source delay time, and the ultrasonic probe continues to work until the first set time is over after the light source device is turned off.
The invention also provides an ultrasonic host, which comprises a controller, wherein the controller comprises:
the ultrasonic pupil measuring device comprises a memory and a processor, wherein the memory and the processor are mutually connected in a communication mode, the memory stores computer instructions, and the processor executes the computer instructions so as to execute any one of the ultrasonic pupil measuring methods.
Optionally, the measurement device includes a display device for displaying the measurement result, and the display device includes a coordinate region for displaying the variation curve and an image display region for displaying the pupil image including the pupil diameter variation.
The invention also provides ultrasonic diagnostic equipment which comprises the ultrasonic host and an ultrasonic probe connected with the ultrasonic host, wherein the light source device is arranged on the ultrasonic probe.
Optionally, the light source device is detachably fixed to the outside of the ultrasonic probe through a mounting bracket.
Optionally, the ultrasonic probe has an installation cavity for accommodating the detection assembly, and the light source device is arranged in the installation cavity.
The technical scheme of the invention has the following advantages:
the invention provides an ultrasonic pupil measurement method, which comprises the following steps: when a pupil measurement instruction is received, the ultrasonic probe is controlled to work, and the light source device is controlled to emit light to the tissue to be measured so as to obtain a pupil image containing pupil diameter change; calculating the pupil diameter of the pupil image; and displaying the change curve of the pupil diameter. According to the ultrasonic pupil measuring method, real-time imaging can be achieved based on the ultrasonic imaging principle, the cost is low, parameters such as pupil size and change rate can be automatically measured without opening the eyelid of a patient, the method is applicable to special scenes such as coma, severe coma and burn, secondary damage caused by opening the eyelid of the patient during measurement can be avoided while time is saved, the measurement is more accurate, and higher value and convenience are provided for clinical diagnosis of doctors. And by controlling the on and off of the light source device and combining the on and off time of the light source device, the sensitivity of the pupil to light response, including the size of the pupil, the shrinkage rate of the pupil, the reduction rate of the pupil and the like, is evaluated, so that an important treatment and diagnosis basis is provided for medical clinic, and scientific, reliable, accurate, convenient and quick measurement means are provided.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
FIG. 1 illustrates a flow chart of a method of ultrasonic pupillometry in an embodiment of the present invention;
fig. 2 is a schematic structural diagram of a wireless high-frequency linear array probe according to an embodiment of the present invention;
fig. 3 is a schematic structural diagram of a wired high-frequency linear array probe according to an embodiment of the present invention;
fig. 4 is a schematic structural diagram of a portable ultrasound host provided in an embodiment of the present invention;
FIG. 5 is a schematic structural diagram of a cart-type ultrasound mainframe provided by an embodiment of the invention;
FIG. 6 is a schematic structural diagram of a tablet ultrasound mainframe according to an embodiment of the present invention;
FIG. 7 is a schematic structural diagram of a handheld ultrasound host according to an embodiment of the present invention;
fig. 8 is a schematic structural diagram illustrating an external light source ultrasonic probe according to an embodiment of the present invention;
FIG. 9 is a schematic structural diagram of an ultrasound probe with a built-in light source according to an embodiment of the present invention;
FIG. 10 is a schematic diagram of a display interface provided by an embodiment of the invention;
FIG. 11 is a schematic diagram of another display interface provided by embodiments of the invention;
fig. 12 is a schematic diagram illustrating a hardware structure of a controller according to an embodiment of the present invention.
Description of reference numerals:
1-wireless high-frequency linear array probe, 2-wired high-frequency linear array probe, 3-portable ultrasonic host, 4-host body, 5-display device, 6-cart type ultrasonic host, 7-flat type ultrasonic host, 8-handheld ultrasonic host; 10-probe body, 11-mounting bracket, 12-external light source, 13-probe shell, 14-light guide plate, 15-acoustic lens, 16-light-transmitting lens, 17-light-emitting piece, 18-mounting cavity, 20-image display area, 21-coordinate display area, 22-optical mark line and 23-measurement result.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it should be understood that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
Fig. 2 to 12 show an ultrasonic diagnostic apparatus provided by an embodiment of the present invention. The ultrasonic diagnostic equipment comprises an ultrasonic host and an ultrasonic probe.
Since different substances or tissues in the human body have different densities and hardnesses from each other, they have different acoustic wave impedances. Ultrasonic imaging is a mode of scanning a human body by using an ultrasonic sound beam, and obtaining an image by receiving and processing a reflection signal. The ultrasonic imaging has the advantages of real-time imaging, low cost and the like, and is widely applied to the medical field. An ultrasonic probe comprises an ultrasonic transducer, i.e. a piezoelectric crystal assembly resonating at ultrasonic frequencies, which converts electrical signals into mechanical vibrations by the piezoelectric effect of the material. An ultrasonic transducer is both a transmitter and a receiver. The ultrasonic imaging device can radiate sound waves into tissues to be measured according to requirements, can receive external sound waves and convert the external sound waves into electric signals, and accordingly scans the tissues to be measured to acquire two-dimensional image data based on the ultrasonic imaging principle.
Fig. 2 and 3 show schematic structural diagrams of the wireless ultrasound probe 1 and the wired ultrasound probe 2, respectively. The wireless ultrasonic probe 1 is connected with the ultrasonic host through wireless communication modes such as WiFi and the like, is not constrained by cables, and is flexible and convenient. The wired ultrasonic probe 2 is directly connected with the ultrasonic host through a cable, and the stability and the reliability of data transmission are guaranteed. The ultrasonic probe transmits the acquired image data to the ultrasonic host computer in a wired or wireless mode. In some preferred embodiments, the ultrasonic probe is a high-frequency linear array probe.
The ultrasonic probe is provided with a light source device. The light source type of the light source device can be white, yellow and the like, the brightness of the light source can be adjusted, and the adjustment of the brightness can be continuous or discontinuous. The ultrasonic probe can be an external light source ultrasonic probe and an internal light source ultrasonic probe according to the arrangement position of the light source device.
Fig. 8 shows an external light source ultrasonic probe, which comprises a probe body 10, an external light source 12 and a mounting bracket 11, wherein the external light source 12 is detachably mounted on the probe body 10 through the mounting bracket 11. As another embodiment, the external light source can be fixed at any position through a mounting bracket and can also be operated by a user in a hand-held mode.
Fig. 9 shows a built-in light source ultrasound probe. The ultrasonic probe is provided with an installation cavity for accommodating the detection assembly, and the light source device is arranged in the installation cavity. Specifically, the ultrasonic probe includes a probe housing 13, a piezoelectric crystal assembly (not shown), a light source device, an acoustic lens 15, and a light-transmitting lens 16. The probe housing 13 has a mounting cavity 18, and a piezoelectric crystal assembly (not shown), a light source device, an acoustic lens 15, and a light-transmitting lens 16 are disposed in the mounting cavity 18.
The piezoelectric crystal component is used for converting electric power into ultrasonic signals to be sent out, and the acoustic lens 15 is arranged at the front end of the piezoelectric crystal component, has good sound wave transmission capacity and is used for sending out ultrasonic waves generated by the piezoelectric crystal component after being subjected to acoustic focusing. The light source device is arranged on the acoustic lens 15, the light source device comprises a light guide plate 14 and a luminous element 17, the light guide plate 14 is of a plate-shaped structure matched with the inner shape of the installation cavity 18, light source grooves are uniformly formed in the length direction of the light guide plate 14, and the luminous element 17 is installed in the light source grooves.
The light transmitting lens 16 is disposed at a front end of the acoustic lens 15, and the light transmitting lens 16 is a lens layer having high light transmittance and wear resistance, and protects the light guide plate 14. The light guide plate 14 and the light transmitting lens 16 function to reflect and transmit light generated from the light emitting member 17.
The built-in light source emits light which directly irradiates the contact position of the ultrasonic probe and the measured person, so that the illumination blind area is reduced, and the illumination effect is improved.
The ultrasonic probe scans the tissue to be detected to acquire image data and is connected and transmitted to the ultrasonic host computer in a wired or wireless mode. The ultrasonic host receives, stores and processes the image data of the ultrasonic probe, and converts the image data into information readable by a user. The ultrasonic host comprises a host body and a display device.
The display device is used for displaying the processing result of the ultrasound host, and the display interface of the display device is as shown in fig. 10 and 11, and comprises a coordinate display area 21 and an image display area 20. The coordinate display area 21 includes a two-dimensional coordinate system, in which the horizontal axis is the acquisition time of the pupil image and the vertical axis is the pupil diameter. The pupil diameter obtained by the processing of the ultrasonic host computer is displayed in the two-dimensional coordinate system in the form of a continuous curve or discrete points. The image display area is used for displaying the processed pupil image. The display device may further include a parameter display area for displaying the item names of the geometric parameters and the specific numerical values corresponding to the item names. By the design, ultrasonic pupil measurement results are displayed from multiple aspects such as graphs and specific quantitative parameters, and visual and accurate data reference is provided for a user.
The type of the ultrasound mainframe can be freely selected according to the actual application scenario, and fig. 4 to 7 show several common types of ultrasound mainframes.
Fig. 4 shows a schematic structural diagram of a portable ultrasound mainframe 3, which includes a mainframe body 4 and a display device 5. The main body 4 and the display device 5 are of square plate-shaped structures with matched shapes. Display device 5 is used for showing supersound host computer measuring result and touch-control operation etc. and a side passes through the hinge rotatable mounting in host computer body 4, can coincide with host computer body 4 after folding, saves space portable. The host body 4 is used for storing and calculating data, a portable structure is arranged on the other side of the hinge, and for convenience of operation, control devices such as a track ball, a rocker and a button are arranged on the side face, close to the display device 5, of the host body 4.
Fig. 5 shows a schematic structural diagram of a cart-type ultrasonic main unit 6, which includes a main unit body 4 and a display device 5. The main body 4 is a cart-type structure with universal wheels at the bottom, so that a user can walk the instrument by hand and move the instrument conveniently. The main body 4 is provided with a workstation inside for processing data and reading patient information, and can inquire and browse checking information and pictures, and also comprises a special probe placing rack, a track ball, a rocker, a button and other control devices. The display device 5 is disposed on the top of the host body 4 and is used for displaying a scanning result, a touch operation, and the like. Preferably, the cart-type ultrasound host 6 further comprises an electric lifting device for adjusting the height, so as to facilitate the use and adjustment of different scenes of different users.
As shown in fig. 6 and 7, the ultrasound host may be a flat-panel ultrasound host or a handheld ultrasound host, the main structures of the flat-panel ultrasound host 7 and the handheld ultrasound host 8 are touch display screens, and a user can perform related operations by touch, and provide various functions such as image zooming, moving, and clicking an interested area by multi-point touch, so that the ultrasound system is small in size and convenient for the user to hold.
The ultrasound host comprises a controller for executing the ultrasound pupil measurement method in the following embodiment 2; as shown in fig. 12, the controller may include a processor 31 and a memory 32, wherein the processor 31 and the memory 32 may be connected by a bus or other means, and fig. 11 illustrates the connection by the bus as an example.
The processor 31 may be a Central Processing Unit (CPU). The Processor 31 may also be other general purpose processors, Digital Signal Processors (DSPs), Application Specific Integrated Circuits (ASICs), Field Programmable Gate Arrays (FPGAs) or other Programmable logic devices, discrete Gate or transistor logic devices, discrete hardware components, or combinations thereof.
The memory 32, which is a non-transitory computer readable storage medium, may be used to store non-transitory software programs, non-transitory computer executable programs, and modules, such as program instructions/modules corresponding to the method for constructing scene information based on execution objects in the embodiment of the present invention. The processor 31 executes various functional applications and data processing of the processor by running the non-transitory software programs, instructions and modules stored in the memory 32, that is, implements the method for constructing scene information based on the execution object in the above method embodiments.
The memory 32 may include a storage program area and a storage data area, wherein the storage program area may store an operating system, an application program required for at least one function; the storage data area may store data created by the processor 31, and the like. Further, the memory 32 may include high speed random access memory, and may also include non-transitory memory, such as at least one magnetic disk storage device, flash memory device, or other non-transitory solid state storage device. In some embodiments, the memory 32 may optionally include memory located remotely from the processor 31, and these remote memories may be connected to the processor 31 via a network. Examples of such networks include, but are not limited to, the internet, intranets, local area networks, mobile communication networks, and combinations thereof.
One or more modules are stored in the memory 32 and, when executed by the processor 31, perform the method of embodiment 2 below.
The details of the computer device can be understood according to the corresponding related descriptions and effects in the following embodiments, and are not described herein again.
It will be understood by those skilled in the art that all or part of the processes of the methods of the following embodiments may be implemented by hardware related to instructions of a computer program, and the computer program may be stored in a computer readable storage medium, and when executed, may include the processes of the embodiments of the methods as described above. The storage medium may be a magnetic Disk, an optical Disk, a Read-Only Memory (ROM), a Random Access Memory (RAM), a Flash Memory (Flash Memory), a Hard Disk (Hard Disk Drive, abbreviated as HDD) or a Solid State Drive (SSD), etc.; the storage medium may also comprise a combination of memories of the kind described above.
Example 2
The embodiment of the invention provides an ultrasonic pupil measurement method, which is applied to ultrasonic diagnosis in embodiment 1, and as shown in fig. 1, the ultrasonic pupil measurement method mainly comprises the following steps:
step S10: when a pupil measurement instruction is received, the ultrasonic probe is controlled to work, and the brightness change of the light source device is controlled, so that a pupil image containing pupil diameter change is obtained;
the ultrasonic probe collects two-dimensional image data of the tissue to be detected and transmits the two-dimensional image data to the ultrasonic host. The on-off and brightness control of the light source device can be realized by the control device on the ultrasonic host and/or the ultrasonic probe. When receiving the pupil measuring instruction, the on, duration, brightness adjustment and off of the light source device are automatically controlled by the automatic measuring system. In the automatic measuring work starting phase, the method also generally comprises the step that a user manually inputs related information such as starting time, duration time, ending time and the like of the light source.
When receiving a pupil measurement instruction, the ultrasonic host controls the ultrasonic probe and the light source device to work, and acquires, stores and calculates image data acquired by the ultrasonic probe, so as to acquire a pupil image containing pupil light reaction. The acquisition of the multiple pupil images can adopt a video framing mode, namely recording a video with a first set time, and then outputting ultrasonic images frame by frame. The method is simple in treatment, short in time interval, uniform and controllable, and very effective in analyzing pupil change. The time interval between ultrasound images can also be adjusted by means of frame decimation.
Obviously, a plurality of ultrasound images can also be obtained by means of time-delay shooting, specifically, one ultrasound image is shot at set intervals within a certain time period, and then a plurality of ultrasound images are obtained.
Step S20: calculating the pupil diameter of the pupil image;
and processing the pupil image which is acquired by the ultrasonic probe and contains the pupil diameter change by adopting an ultrasonic image processing algorithm to obtain the contour shape of the corresponding pupil. The pupil in the pupil image acquired by the ultrasonic diagnostic equipment is a dark area and is usually located in the middle of the image, but the eyeball of a person does not rotate autonomously, and the edge of the pupil is blurred or the pupil is elliptical due to the upturning or the lateral inclination of the eyeball. The pupil contour may be generally approximate to an elliptical shape, and the geometric parameters important for the pupil contour generally include one or more of the circumference, eccentricity, right and left diameters, pupil diameter (pupil vertical center position), etc. of the ellipse, which are used to correspond to the size and shape of the pupil. And obtaining the pupil contour to obtain the relevant geometric parameters of the pupil contour. The relevant geometric parameters of the pupil profile should be able to characterize the shape as well as the size of the pupil profile.
In this embodiment, too, in most practical applications, the size of the pupil can be expressed by the pupil diameter alone. The principle of automatically measuring the pupil diameter after obtaining the contour of the pupil is consistent with the method of manual measurement.
Step S30: and displaying the change curve of the pupil diameter.
The pupil diameter of the pupil-capable image is obtained in step S20. The pupil diameters of the multiple pupil images may form a variation curve. The variation curve can visually represent the size variation of the pupil diameter. The pupil changes are dynamically observed and evaluated by these changes. The dynamic change of the pupil can not only discover the premonitory symptoms of the disease and grasp the best and more treatment opportunities, but also prevent the occurrence of complications, and has important clinical significance, especially in the examination and monitoring of emergency treatment and intensive care monitoring rooms.
According to the ultrasonic pupil measuring method, real-time imaging can be achieved based on the ultrasonic imaging principle, the cost is low, parameters such as pupil size and change rate can be automatically measured without opening the eyelid of a patient, the method is applicable to special scenes such as coma, severe coma and burn, secondary damage caused by opening the eyelid of the patient during measurement can be avoided while time is saved, the measurement is more accurate, and higher value and convenience are provided for clinical diagnosis of doctors. And by controlling the on and off of the light source device and combining the on and off time of the light source device, the sensitivity of the pupil to light response, including the size of the pupil, the shrinkage rate of the pupil, the reduction rate of the pupil and the like, is evaluated, so that an important treatment and diagnosis basis is provided for medical clinic, and scientific, reliable, accurate, convenient and quick measurement means are provided.
Optionally, in some embodiments of the present invention, step S20 of the ultrasonic pupil measurement method includes:
calculating the pupil diameter of each pupil image according to a preset algorithm;
specifically, image preprocessing, image segmentation and ellipse fitting are respectively performed on each pupil image to calculate the pupil diameter of one pupil image. The preprocessing program comprises the steps of image denoising, image enhancement and the like so as to obtain an ultrasonic image with higher resolution and clearer edge characteristics and provide a good basis for image segmentation.
The purpose of pupil segmentation is to obtain the position of a pupil in an ultrasonic image, and an adaptive threshold image segmentation algorithm, an image segmentation algorithm based on an energy model, an image segmentation algorithm model based on deep learning and the like can be selected for realization. Common image segmentation algorithms based on energy models comprise Snake, Level-Set and the like, and common image segmentation algorithm models based on deep learning comprise U-Net, U-Net improved versions and the like.
And performing shape fitting on the pupil based on the ultrasonic image after segmentation. Generally, the outline of the pupil can be approximated to an ellipse, so that the Hough-based ellipse fitting algorithm can be selected for the graphic fitting of the outline. Obviously, other ellipse fitting algorithms may be employed. And obtaining an ellipse corresponding to the pupil outline to obtain the pupil diameter representing the size of the pupil.
Displaying the variation curve of the pupil diameter based on each pupil image.
Referring to fig. 10 and 11, a display interface of the display device includes a coordinate display area 21. The coordinate display area 21 includes a two-dimensional coordinate system, and the horizontal axis of the coordinate system is the acquisition time of the pupil image, and the vertical axis is the pupil diameter of the pupil image. And each pupil image corresponds to one acquisition time, the pupil diameter corresponding to each pupil image is displayed in a coordinate system formed by the acquisition time of the pupil image and the pupil diameter, and then the pupil images are smoothly connected to form a change curve. Obviously, the shorter the acquisition time interval, the more pupil images are acquired, and the more accurate the change curve is. By the design, the change relation of the pupil diameter along with the acquisition time is more intuitively represented. The light response of the pupil can be evaluated by combining the on and off time of the light source device.
Optionally, in some embodiments of the present invention, as shown in fig. 11, an image display area 20 for displaying the pupil image is included above the coordinate display area 21 in the display interface. The display interface also displays a cursor line 22 disposed perpendicular to the abscissa. The user may drag the cursor line 22 to move along the abscissa. The image display area 20 displays the pupil image of the cursor line 22 corresponding to the acquisition time.
Further, a measuring tool is also included. As shown in fig. 11, when the user uses the measuring tool, two points of the pupil image are selected in the image display area 20, and the distance between the two points is directly measured to obtain the measured diameter. The measurement results 23 of the measurement tool are displayed on the display interface. Measuring the diameter provides more clinical reference for the user.
Further, an interactive function may be added, that is, the user may arbitrarily select a period of time as the calculation cycle, and calculate the change of the pupil diameter in the period of time, the change including the maximum value, the minimum value, the change rate, and the like in the period of time. The time period can be selected on the time axis of a two-dimensional coordinate system in the ultrasonic host display device, namely, the display device selects a touch screen with a touch input function. The time interval may also be entered manually. By the design, the display interval and the display proportion can be automatically adjusted, the requirements of users are met, and more specific and accurate clinical basis is provided.
Optionally, in some embodiments of the present invention, the controlling the operation of the ultrasonic probe and the controlling the light source device to emit light to the tissue to be measured includes:
when the ultrasonic probe works, the light source device is controlled to emit light for a second set time after the set light source delay time, and the ultrasonic probe continues to work until the first set time is over after the light source device is turned off. It should be noted that the first set time is the time from the beginning to the end of the operation of the ultrasonic probe in the measurement process, and should be not less than the light source delay time and the second set time.
Further, receiving a first set time, a second set time and a light source delay time input by a user;
and controlling the light source to work according to the first set time, the second set time and the light source delay time.
For example, when the user inputs a first set time of 5 seconds, a second set time of 1 second, and a light source delay of 1 second. The ultrasonic probe acquires an ultrasonic image for 5 seconds, wherein the 1 st second is light source delay time, the light source device is closed to be used as a standard reference, the 2 nd second controls the light source device to be opened to realize pupil contraction, and the 2 nd second controls the light source device to be closed; and the light source device is in a closed state in 3 to 5 seconds, and the pupil is expanded again.
Obviously, the first setting time, the second setting time, the light source delay time, the light source type, the brightness and other parameters can be changed and set according to actual requirements.
It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are within the scope of the invention.

Claims (14)

1. An ultrasonic pupil measurement method is applied to ultrasonic diagnosis equipment, the ultrasonic diagnosis equipment comprises an ultrasonic probe, and a light source device is installed on the ultrasonic probe, and the method is characterized by comprising the following steps:
when a pupil measurement instruction is received, the ultrasonic probe is controlled to work, and the brightness change of the light source device is controlled, so that a pupil image containing pupil diameter change is obtained;
calculating the pupil diameter of the pupil image;
and displaying the change curve of the pupil diameter.
2. The method as claimed in claim 1, wherein said calculating the pupil diameter of the pupil image and displaying the variation curve of the pupil diameter comprises:
calculating the pupil diameter of each pupil image according to a preset algorithm;
displaying the variation curve of the pupil diameter based on each pupil image.
3. The method according to claim 2, wherein the calculating the pupil diameter of each of the pupil images according to a preset algorithm comprises:
performing image preprocessing, image segmentation and ellipse fitting on each pupil image to calculate the pupil diameter of one pupil image, wherein the image segmentation comprises one or more of the following modes:
the image segmentation is realized based on an adaptive threshold image segmentation algorithm, the image segmentation is realized based on an energy model image segmentation algorithm, and the image segmentation is realized based on an energy model image segmentation algorithm.
4. The method of claim 1, wherein the variation curve is plotted on an abscissa with respect to acquisition time and on an ordinate with respect to the pupil diameter.
5. The method of claim 4, further comprising: displaying a pupil image containing pupil diameter change, wherein the pupil image and the change curve of the pupil diameter are on the same display interface.
6. The method of claim 5, wherein the display interface further displays a cursor line indicating a value corresponding to an abscissa at a time, the cursor line being perpendicular to the abscissa and/or the ordinate.
7. The method of claim 6, further comprising: and when the cursor points to a certain moment, displaying the pupil image corresponding to the moment on the display interface.
8. The method of claim 5, further comprising:
when a measuring instruction is received, obtaining a measuring diameter according to the two selected points of the pupil image;
and displaying the measured diameter on the display interface.
9. The method according to claim 1, wherein the controlling the operation of the ultrasonic probe and the controlling the light source device to emit light to the tissue to be measured comprises:
when the ultrasonic probe works, the light source device is controlled to emit light for a second set time after the set light source delay time;
and after the light source device is turned off, the ultrasonic probe continues to work until the first set time is over.
10. An ultrasound mainframe comprising a controller, the controller comprising:
a memory and a processor, the memory and the processor being communicatively connected to each other, the memory having stored therein computer instructions, the processor executing the computer instructions to perform the ultrasonic pupillary measurement method of any one of claims 1-9.
11. The ultrasound mainframe of claim 10, wherein: the device comprises a display device for displaying the measurement result, wherein the display device comprises a coordinate area for displaying the change curve and an image display area for displaying the pupil image containing the pupil diameter change.
12. An ultrasonic diagnostic apparatus characterized in that: the ultrasonic probe comprises the ultrasonic host machine of claim 10 or 11 and an ultrasonic probe connected with the ultrasonic host machine, wherein the light source device is installed on the ultrasonic probe.
13. The ultrasonic diagnostic apparatus according to claim 12, characterized in that: the light source device is detachably fixed outside the ultrasonic probe through a mounting bracket.
14. The ultrasonic diagnostic apparatus according to claim 12, characterized in that: the ultrasonic probe is provided with an installation cavity for accommodating the detection assembly, and the light source device is arranged in the installation cavity.
CN201910973501.0A 2019-10-14 2019-10-14 Ultrasonic pupil measuring method, ultrasonic host and ultrasonic diagnostic equipment Pending CN112716443A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113558575A (en) * 2021-07-20 2021-10-29 苏州科技城医院 Anesthesia depth monitoring system and detection method based on pupil change under ultrasound

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113558575A (en) * 2021-07-20 2021-10-29 苏州科技城医院 Anesthesia depth monitoring system and detection method based on pupil change under ultrasound
WO2023000771A1 (en) * 2021-07-20 2023-01-26 苏州科技城医院 Ultrasound pupil change-based anesthesia depth monitoring system and detection method

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