CN112680345A - Biological cell is cultivated with observation case that has cycle recording function - Google Patents
Biological cell is cultivated with observation case that has cycle recording function Download PDFInfo
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- CN112680345A CN112680345A CN202011612768.6A CN202011612768A CN112680345A CN 112680345 A CN112680345 A CN 112680345A CN 202011612768 A CN202011612768 A CN 202011612768A CN 112680345 A CN112680345 A CN 112680345A
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- box
- bevel gear
- fixedly connected
- observation
- recording function
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- 230000005540 biological transmission Effects 0.000 claims abstract description 30
- 230000006870 function Effects 0.000 claims abstract description 22
- 238000004113 cell culture Methods 0.000 claims abstract description 19
- 230000000737 periodic effect Effects 0.000 claims description 11
- 239000003638 chemical reducing agent Substances 0.000 claims description 10
- 238000005192 partition Methods 0.000 claims description 7
- 230000001276 controlling effect Effects 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000009413 insulation Methods 0.000 claims description 5
- 230000017525 heat dissipation Effects 0.000 claims description 4
- 230000001105 regulatory effect Effects 0.000 claims description 4
- 230000002146 bilateral effect Effects 0.000 claims description 3
- 239000011521 glass Substances 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 230000000712 assembly Effects 0.000 claims 2
- 238000000429 assembly Methods 0.000 claims 2
- 230000012010 growth Effects 0.000 abstract description 4
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 6
- 230000033228 biological regulation Effects 0.000 description 2
- 230000010261 cell growth Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000010370 cell cloning Methods 0.000 description 1
- 238000012411 cloning technique Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
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Abstract
The invention discloses an observation box with a period recording function for biological cell cultivation, and relates to an observation box for biological cell cultivation. Compared with the prior art, the invention has the beneficial effects that: the rotation that the culture dish can the controllability makes things convenient for the experimenter's observation, and the whole growth condition of cell in the record camera whole record culture dish stores image data transmission to the memory in, can transfer out data through the computer at any time, and the observation box in should is in-service use effectual.
Description
Technical Field
The invention relates to an observation box for biological cell cultivation, in particular to an observation box with a period recording function for biological cell cultivation.
Background
Cell culture refers to a method of simulating in vivo environment (sterile, proper temperature, pH value, certain nutritional conditions, etc.) in vitro to enable the cells to survive, grow, reproduce and maintain the main structure and function. Cell culture is also called cell cloning technology, and the formal term in biology is cell culture technology. Cell culture is an essential process for both the whole bioengineering technique and one of the biological cloning techniques,
the observation box is the professional equipment that is used for cell culture, and the culture ware wherein current biological cell cultivates the observation box is fixed, and the observation of experimenter is not convenient for, all need take out usually and carry out careful observation, and the record about the cell growth condition among the prior art is mostly through carrying out manual record after the special messenger observes, and this kind of mode can cause experimental data's deviation unavoidably to influence final experimental conclusion. Therefore, an observation box which is convenient to observe and can record data such as cell growth cycle is needed.
To this end, those skilled in the art have proposed a viewing chamber for biological cell culture having a cycle recording function to solve the problems set forth in the background above.
Disclosure of Invention
The present invention is directed to provide an observation box with cycle recording function for biological cell cultivation, so as to solve the problems mentioned in the background art.
In order to achieve the purpose, the invention provides the following technical scheme:
the utility model provides an observation box that biological cell cultivates with having cycle recording function, includes the box, rotates on the box to articulate has the observation door, and fixed connection has the headstock in the box, rotate on the lateral wall on the headstock and be connected with the guide shaft that runs through, the front-back bilateral symmetry of guide shaft sets up, and guide shaft upper end fixedly connected with tray is provided with the culture dish on the tray, and the guide shaft lower extreme has linked firmly first bevel gear, the headstock bottom is rotated and is connected with power input shaft, and power input shaft upper end has linked firmly the worm wheel, and power input shaft lower extreme fixedly connected with driven bevel gear rotates on the lateral wall about the headstock and is connected with the transmission shaft, and the symmetry sets up around the transmission shaft, the transmission shaft middle part is worm formula structure, transmission shaft and worm wheel meshing transmission, and the symmetry is provided with the regulation and.
As a further scheme of the invention: the observation door is fixedly connected with a handle, and the observation door is made of glass.
As a still further scheme of the invention: the left side of the bottom of the box body is fixedly connected with a motor, the right side of the motor is provided with a speed reducer, the output end of the motor is connected with the speed reducer, the output end of the speed reducer is fixedly connected with a driving bevel gear, and the driving bevel gear is in meshing transmission with a driven bevel gear.
As a still further scheme of the invention: the power box top is provided with the baffle, and the power box below is provided with the insulating layer, and baffle and insulating layer all with box inner wall sealing fixed connection.
As a still further scheme of the invention: the box front side is opened there is the louvre, and the louvre is located the headstock downside, and the box front side is provided with a plurality of button.
As a still further scheme of the invention: the utility model discloses a power box, including power box, regulation and control subassembly, the sleeve slides and cup joints transmission shaft, and the sleeve is inside to be opened to have the symmetry to be provided with the draw-in groove, and the card strip that fixedly connected with symmetry set up on the transmission shaft, the card strip cooperatees with the draw-in groove, open the circumference groove on the sleeve, the shift fork cooperatees with the circumference groove, and connecting rod fixed welding is on the shift fork, sleeve right-hand member fixedly connected with second bevel gear, and second bevel gear cooperatees with first bevel gear position, it has the spout to open on the headstock front side rear wall, spout bilateral symmetry sets up, and the connecting rod passes the spout as for the headstock outside, has cup jointed the snap ring on the connecting rod, and snap ring sliding connection is in the spout, fixedly connected with spring between.
As a still further scheme of the invention: a sensor is fixed at the center of the partition plate, and a storage device is arranged on the right side of the bottom of the box body.
As a still further scheme of the invention: the recording camera is fixed on the left side wall and the right side wall of the box body, the heating lamp is arranged on the left side wall of the box body, and the humidifier is fixed on the right side wall of the box body.
As a still further scheme of the invention: the length of the clamping strip is greater than that of the sliding groove.
As a still further scheme of the invention: the tooth number of the driving bevel gear is less than that of the driven bevel gear.
Compared with the prior art, the invention has the beneficial effects that: firstly, a power input shaft is driven to rotate through a motor, transmission shafts on the front side and the rear side are driven, a through hole button controls an electromagnet to be electrified, a second bevel gear in a regulating and controlling assembly is meshed with a first bevel gear to drive a corresponding guide shaft to rotate, a culture dish on a tray above the regulating and controlling assembly is rotated, and observation of experimenters is facilitated;
the growth condition of cells in the culture dish is recorded through the whole process of the recording camera, the image data are transmitted to the storage device to be stored, experimenters can call out the data through a computer at any time to carry out statistical recording, and meanwhile, comparison can be carried out, data errors are avoided, and the observation box is good in actual use effect and suitable for popularization.
Drawings
FIG. 1 is a schematic view showing the structure of a chamber for biological cell culture having a cycle recording function;
FIG. 2 is a schematic view showing the inside structure of a observation box having a cycle recording function for biological cell cultivation;
FIG. 3 is a schematic diagram showing the structure of a control module in an observation box with cycle recording function for biological cell culture;
FIG. 4 is a schematic diagram showing the structure of a kit for a control module in an observation box with a cycle recording function for culturing biological cells;
in the figure: 1-box body, 2-observation door, 3-power box, 4-guide shaft, 5-tray, 6-culture dish, 7-first bevel gear, 8-power input shaft, 9-worm gear, 10-driven bevel gear, 11-transmission shaft, 12-regulation and control component, 13-handle, 14-motor, 15-reducer, 16-driving bevel gear, 17-clapboard, 18-heat insulation layer, 19-heat dissipation hole, 20-button, 21-sleeve, 22-shifting fork, 23-connecting rod, 24-clamping strip, 25-second bevel gear, 26-chute, 27-clamping ring, 28-spring, 29-mounting plate, 30-electromagnet, 31-sensor, 32-memory, 33-recording camera, etc, 34-heating lamp, 35-humidifier.
Detailed Description
The technical solution of the present patent will be described in further detail with reference to the following embodiments.
The first embodiment is as follows: referring to fig. 1, an observation box for biological cell cultivation with periodic recording function comprises a box body 1, an observation door 2 rotatably hinged on the box body 1,
referring to fig. 2, a power box 3 is fixedly connected in a box body 1, a through guide shaft 4 is rotatably connected to the upper side wall of the power box 3, the guide shaft 4 is symmetrically arranged in a front-back and left-right direction, a tray 5 is fixedly connected to the upper end of the guide shaft 4, a culture dish 6 is arranged on the tray 5, a first bevel gear 7 is fixedly connected to the lower end of the guide shaft 4, a power input shaft 8 is rotatably connected to the bottom of the power box 3, a worm wheel 9 is fixedly connected to the upper end of the power input shaft 8, a driven bevel gear 10 is fixedly connected to the lower end of the power input shaft 8, transmission shafts 11 are rotatably connected to the left side wall and the right side wall of the power box 3, the transmission shafts 11 are symmetrically arranged in a front-back direction, the middle of the transmission shafts 11 is of a worm structure, the transmission shafts.
Referring to fig. 1, a handle 13 is fixedly connected to the observation door 2, and the observation door 2 is made of glass.
Referring to fig. 2, a motor 14 is fixedly connected to the left side of the bottom of the box 1, a speed reducer 15 is arranged on the right side of the motor 14, an output end of the motor 14 is connected to the speed reducer 15, an output end of the speed reducer 15 is fixedly connected to a driving bevel gear 16, and the driving bevel gear 16 is in meshing transmission with a driven bevel gear 10.
Referring to fig. 2, a partition plate 17 is arranged above the power box 3, a heat insulation layer 18 is arranged below the power box 3, and both the partition plate 17 and the heat insulation layer 18 are fixedly connected with the inner wall of the box body 1 in a sealing manner.
Referring to fig. 1, heat dissipation holes 19 are formed in the front side of the box body 1, the heat dissipation holes 19 are located on the lower side of the power box 3, and a plurality of buttons 20 are arranged on the front side of the box body 1.
Referring to fig. 2-4, the adjusting and controlling assembly 12 includes a sleeve 21, a shifting fork 22 and a connecting rod 23, the sleeve 21 is slidably sleeved on the transmission shaft 11, the sleeve 21 is provided with symmetrically arranged slots, the transmission shaft 11 is fixedly connected with symmetrically arranged clamping strips 24, the clamping strips 24 are matched with the slots, the upper end of the sleeve 21 is provided with a circumferential groove, the shifting fork 22 is matched with the circumferential groove, the connecting rod 23 is fixedly welded on the shifting fork 22, the right end of the sleeve 21 is fixedly connected with a second bevel gear 25, the second bevel gear 25 is matched with the first bevel gear 7, the rear wall of the front side of the power box 3 is provided with a sliding groove 26, the sliding groove 26 is symmetrically arranged in the left-right direction, the connecting rod 23 passes through the sliding groove 26 and is arranged outside the power box 3, the connecting rod 23 is sleeved with a snap ring 27, the snap ring 27 is slidably connected in the sliding groove 26, a spring, an electromagnet 30 is provided on the mounting plate 29.
The starting motor 14 drives the power input shaft 8 to rotate through the meshing transmission of the driving bevel gear 16 and the driven bevel gear 10, so that the transmission shafts 11 on the front side and the rear side are electrified under the control of the through hole buttons 20, the corresponding electromagnets 30 are controlled to be electrified, the connecting rod 23 moves in the sliding groove 26, the spring 28 is extruded, the second bevel gear 25 on the sleeve 21 is driven by the shifting fork 22 to be meshed with the first bevel gear 7, the corresponding guide shaft 4 is driven to rotate, the culture dish 6 on the tray 5 above the guide shaft is driven to rotate, and the observation of experimenters;
the length of the card strip 24 is greater than the length of the slide groove 26.
The number of teeth of the drive bevel gear 16 is smaller than that of the driven bevel gear 10.
Example two: this embodiment is a further improvement of the previous embodiment:
referring to fig. 2, a sensor 31 is fixed at the center of the partition 17, a memory 32 is arranged at the right side of the bottom of the case 1, recording cameras 33 are fixed on the left and right side walls of the case 1, a heating lamp 34 is arranged on the left side wall of the case 1, and a humidifier 35 is fixed on the right side wall of the case 1.
The growth condition of the cells in the culture dish 6 is recorded in the whole process through the recording camera 33, the image data is transmitted to the memory 32 for storage, experimenters can call out the data through a computer at any time for statistical recording and comparison, and data errors are avoided; the data of the temperature and the humidity in the box body can be monitored in real time through the sensor 31, the heating lamp 34 and the humidifier 35 are controlled to work, and the environment in the box body is adjusted at any time.
The working principle of the invention is as follows: the starting motor 14 drives the power input shaft 8 to rotate through the meshing transmission of the driving bevel gear 16 and the driven bevel gear 10, so that the transmission shafts 11 on the front side and the rear side are electrified under the control of the through hole buttons 20, the corresponding electromagnets 30 are controlled to be electrified, the connecting rod 23 moves in the sliding groove 26, the spring 28 is extruded, the second bevel gear 25 on the sleeve 21 is driven by the shifting fork 22 to be meshed with the first bevel gear 7, the corresponding guide shaft 4 is driven to rotate, the culture dish 6 on the tray 5 above the guide shaft is driven to rotate, and the observation of experimenters; the growth condition of the cells in the culture dish 6 is recorded in the whole process through the recording camera 33, the image data is transmitted to the memory 32 for storage, experimenters can call out the data through a computer at any time for statistical recording and comparison, and data errors are avoided; the data of the temperature and the humidity in the box body can be monitored in real time through the sensor 31, the heating lamp 34 and the humidifier 35 are controlled to work, and the environment in the box body is adjusted at any time.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (10)
1. An observation box with a periodic recording function for biological cell cultivation comprises a box body (1), wherein an observation door (2) is hinged on the box body (1) in a rotating manner, a power box (3) is fixedly connected in the box body (1), and is characterized in that a through guide shaft (4) is connected on the side wall of the power box (3) in a rotating manner, the guide shaft (4) is symmetrically arranged front and back and left and right, a tray (5) is fixedly connected at the upper end of the guide shaft (4), a culture dish (6) is arranged on the tray (5), a first bevel gear (7) is fixedly connected at the lower end of the guide shaft (4), a power input shaft (8) is rotatably connected at the bottom of the power box (3), a worm gear (9) is fixedly connected at the upper end of the power input shaft (8), a driven bevel gear (10) is fixedly connected at the lower end of the power input shaft (8), and a transmission, the transmission shaft (11) is symmetrically arranged in the front and back direction, the middle of the transmission shaft (11) is of a worm type structure, the transmission shaft (11) is in meshed transmission with the worm wheel (9), the transmission shaft (11) is symmetrically provided with regulating and controlling assemblies (12), and the regulating and controlling assemblies (12) are matched with the first bevel gear (7).
2. The observation box with periodic recording function for cultivating biological cells according to claim 1, wherein the observation door (2) is fixedly connected with a handle (13), and the observation door (2) is made of glass.
3. The observation box with the periodic recording function for the cultivation of biological cells according to claim 1, wherein a motor (14) is fixedly connected to the left side of the bottom of the box body (1), a speed reducer (15) is arranged on the right side of the motor (14), the output end of the motor (14) is connected with the speed reducer (15), a driving bevel gear (16) is fixedly connected to the output end of the speed reducer (15), and the driving bevel gear (16) is in meshing transmission with the driven bevel gear (10).
4. The observation box with the periodic recording function for the cultivation of biological cells according to claim 1, characterized in that a partition plate (17) is arranged above the power box (3), a heat insulation layer (18) is arranged below the power box (3), and the partition plate (17) and the heat insulation layer (18) are fixedly connected with the inner wall of the box body (1) in a sealing manner.
5. The observation box with periodic recording function for cultivating biological cells according to claim 1 or 4, wherein the front side of the box body (1) is provided with heat dissipation holes (19), the heat dissipation holes (19) are located at the lower side of the power box (3), and the front side of the box body (1) is provided with a plurality of buttons (20).
6. The observation box with the periodic recording function for the cultivation of biological cells according to claim 1, wherein the adjusting and controlling assembly (12) comprises a sleeve (21), a shifting fork (22) and a connecting rod (23), the sleeve (21) is slidably sleeved on the upper transmission shaft (11), the sleeve (21) is symmetrically provided with clamping grooves, the transmission shaft (11) is fixedly connected with symmetrically arranged clamping strips (24), the clamping strips (24) are matched with the clamping grooves, the upper end of the sleeve (21) is provided with a circumferential groove, the shifting fork (22) is matched with the circumferential groove, the connecting rod (23) is fixedly welded on the shifting fork (22), the right end of the sleeve (21) is fixedly connected with a second bevel gear (25), the second bevel gear (25) is matched with the first bevel gear (7), the rear wall of the front side of the power box (3) is provided with a sliding groove (26), and the sliding grooves (26) are arranged in a bilateral symmetry way, connecting rod (23) pass spout (26) as for headstock (3) outside, have cup jointed snap ring (27) on connecting rod (23), snap ring (27) sliding connection is in spout (26), fixedly connected with spring (28) between snap ring (27) and spout (26), fixedly connected with mounting panel (29) is gone up in headstock (3), is provided with electro-magnet (30) on mounting panel (29).
7. The observation box with periodic recording function for biological cell cultivation according to claim 4, characterized in that the sensor (31) is fixed on the center of the partition board (17), and the memory (32) is arranged on the right side of the bottom of the box body (1).
8. The observation box with periodic recording function for cultivating biological cells according to claim 1, wherein the recording cameras (33) are fixed on the left and right side walls of the box body (1), the heating lamp (34) is arranged on the left side wall of the box body (1), and the humidifier (35) is fixed on the right side wall of the box body (1).
9. The observation box for biological cell cultivation with periodic recording function according to claim 6, characterized in that the length of the card strip (24) is longer than the length of the chute (26).
10. The observation box for biological cell cultivation with periodic recording function according to claim 3, wherein the number of teeth of the driving bevel gear (16) is smaller than that of the driven bevel gear (10).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011612768.6A CN112680345A (en) | 2020-12-30 | 2020-12-30 | Biological cell is cultivated with observation case that has cycle recording function |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011612768.6A CN112680345A (en) | 2020-12-30 | 2020-12-30 | Biological cell is cultivated with observation case that has cycle recording function |
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| Publication Number | Publication Date |
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| CN112680345A true CN112680345A (en) | 2021-04-20 |
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| CN202011612768.6A Pending CN112680345A (en) | 2020-12-30 | 2020-12-30 | Biological cell is cultivated with observation case that has cycle recording function |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102827758A (en) * | 2012-09-24 | 2012-12-19 | 长春理工大学 | Cell microscopic observation monitor in cell factory |
| KR20160127869A (en) * | 2015-04-27 | 2016-11-07 | 주식회사 로보테크 | System for cell culture is sealed and controlled by external terminal |
| CN109777736A (en) * | 2019-01-29 | 2019-05-21 | 美闺(长沙)医疗美容有限公司 | A kind of live cell assays device and method |
| CN111254072A (en) * | 2018-12-01 | 2020-06-09 | 宿迁普朗克生物科技有限公司 | Culture equipment convenient to observe production of budding of yeast |
| CN212152349U (en) * | 2020-04-23 | 2020-12-15 | 贵州医科大学附属医院 | Stem cell constant temperature culture container |
-
2020
- 2020-12-30 CN CN202011612768.6A patent/CN112680345A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102827758A (en) * | 2012-09-24 | 2012-12-19 | 长春理工大学 | Cell microscopic observation monitor in cell factory |
| KR20160127869A (en) * | 2015-04-27 | 2016-11-07 | 주식회사 로보테크 | System for cell culture is sealed and controlled by external terminal |
| CN111254072A (en) * | 2018-12-01 | 2020-06-09 | 宿迁普朗克生物科技有限公司 | Culture equipment convenient to observe production of budding of yeast |
| CN109777736A (en) * | 2019-01-29 | 2019-05-21 | 美闺(长沙)医疗美容有限公司 | A kind of live cell assays device and method |
| CN212152349U (en) * | 2020-04-23 | 2020-12-15 | 贵州医科大学附属医院 | Stem cell constant temperature culture container |
Non-Patent Citations (1)
| Title |
|---|
| 胡立明等主编: "《工程力学与机械设计基础》", 中国科学技术大学出版社, pages: 221 * |
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