CN112674337A - Application of fucoxanthin and/or fucoxanthin in preparation for improving DHA level of human body - Google Patents
Application of fucoxanthin and/or fucoxanthin in preparation for improving DHA level of human body Download PDFInfo
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Abstract
The invention belongs to the technical field of fucoxanthin and fucoxanthin alcohol application, and particularly relates to application of fucoxanthin and/or fucoxanthin alcohol in a product for improving DHA (docosahexaenoic acid) level in a human body. The product is prepared from animal meat with high DHA content; the animal meat is obtained by taking fucoxanthin and/or fucoxanthin into animals. Fucoxanthin andor fucoxanthin alcohol promotes DHA deposition in animal muscle, reduces fat content and cholesterol level, improves the nutritional quality of meat, and people can absorb DHA by eating the muscle product with high DHA content, thereby achieving the purpose of improving DHA level in human body.
Description
The technical field is as follows:
the invention belongs to the technical field of fucoxanthin and fucoxanthin alcohol application, and particularly relates to application of fucoxanthin and/or fucoxanthin alcohol in a product for improving human DHA level.
Background art:
docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, is a major component of the growth and maintenance of nervous system cells, is essential for brain development in fetal and infant stages, and is an important component of the retina, contributing to improvement of vision. The DHA synthesized by the human body is very limited, and only the most basic normal physiological functions and health can be ensured, so that the human body generally needs to take sufficient DHA by dietary supplement.
In order to supplement DHA, people usually choose to take purified DHA health products or medicines. However, DHA is mainly derived from deep sea fish oil and marine algae, but its yield and quality are severely reduced due to over-fishing of fish and marine environmental pollution, and it has not been possible to meet the increasing market demand, and thus, there is still a need to develop a more natural DHA uptake pattern.
In recent years, as the standard of living is improved, the amount of meat ingested by people is gradually increased. Meat products mainly contain saturated fatty acid and contain high cholesterol, and excessive intake of the meat products can increase the risks of atherosclerosis, coronary heart disease, myocardial infarction and cerebral apoplexy. Therefore, how to reduce the content of cholesterol and fat in meat and improve the quality of meat is a focus of attention.
Fucoxanthin (fucoxanthin), also known as fucoxanthin and fucoxanthin, is a natural pigment of xanthophylls in carotenoids, accounts for more than 10% of the total of about 700 naturally occurring carotenoids, is pale yellow to brown in color, and is a pigment contained in brown algae, diatoms, chrysophyceae and chrysophyceae; it is widely available in various algae, marine phytoplankton, aquatic shellfish and other animals and plants. Studies by TSUKUI et al indicate that fucoxanthin or fucoxanthin alcohol can increase DHA levels in the liver, while DHA levels in the gut remain unchanged, indicating that the effects of fucoxanthin or fucoxanthin alcohol in different tissues may be different. It has not been reported whether fucoxanthin or fucoxanthin can promote the increase of the DHA content in other tissues except liver and reduce the fat content and cholesterol level, especially the effect on the DHA content in muscle. Therefore, whether the DHA content in the muscle can be increased by eating the fucoxanthin and/or the fucoxanthin, and the DHA level in the human body can be increased by eating the DHA-enhanced muscle and the products thereof is still to be researched.
The invention content is as follows:
the invention aims to solve the technical problem that the DHA synthesized by a human body is very limited, and people usually choose to take purified DHA health-care products or medicines in order to supplement the DHA. At present, DHA is mainly derived from deep sea fish oil and marine algae, but the yield and the quality of DHA are seriously reduced due to over fishing of fishes and marine environmental pollution, and the DHA cannot meet the increasing market demand, so that the development of a more natural DHA intake mode is required.
In order to solve the problems, the invention provides the application of the fucoxanthin and/or the fucoxanthin in the product for improving the DHA level in the human body, the fucoxanthin and/or the fucoxanthin are used for promoting the DHA deposition in animal muscles, reducing the fat content and the cholesterol level and improving the nutritional quality of meat, and people can absorb the DHA by eating the muscle product with high DHA content, thereby realizing the aim of improving the DHA level in the human body.
In order to achieve the aim, the invention is realized by the following technical scheme that the fucoxanthin andor fucoxanthin alcohol is applied to a product for improving the DHA level in human bodies, and the product is prepared from animal meat with high DHA content; the animal meat is obtained by taking fucoxanthin and/or fucoxanthin into animals. The invention uses fucoxanthin and/or fucoxanthin to promote DHA deposition in animal muscles, and uses the muscles to prepare products for improving DHA level in human bodies. After the fucoxanthin is taken into the animal body, most of the fucoxanthin is hydrolyzed into fucoxanthin under the action of digestive enzyme in the gastrointestinal tract, and the fucoxanthin enters systemic circulation through lymph; part of the DHA is degraded in the liver into Amaroucaxanthin A and other substances, and then further reactions such as isomerization, dehydrogenation, deacetylation and the like are carried out, wherein the liver is stimulated to increase the DHA level. Linolenic Acid (ALA) as a precursor for the synthesis of DHA has the ability to synthesize DHA (primarily by an unsaturated enzyme and an elongase). In the reaction for synthesizing DHA by using ALA as a precursor in animals, the delta 6 desaturase for synthesizing C18:4(n-3) in the first step is the rate-limiting enzyme of the reaction, and fucoxanthin can promote C18: 3 to C18: 4. Since muscle normally contains n-3 fatty acids within 20 carbons, fucoxanthin and its metabolites that enter muscle tissue via systemic circulation may be separated by the compounds that promote C20: 5 to DHA, so as to achieve the aim of improving the DHA content in the muscle. Therefore, fucoxanthin or fucoxanthin can increase DHA level in muscle and liver by two ways, and the reaction is different. Therefore, the fucoxanthin and/or the fucoxanthin can be used as a feed additive, the DHA in the muscle of the animal body is improved by oral intake to improve the nutritional quality of the meat of the cultured animal, and the muscle can be reused to prepare a product for improving the DHA level in the human body. The DHA level in the body can be increased by eating the product.
Further, the use of fucoxanthin and/or fucoxanthin alcohol for reducing the level of fat and cholesterol in a product. As described above, fucoxanthin and/or fucoxanthin can increase the DHA content in muscle, and also can reduce the fat content and cholesterol level in muscle by inhibiting lipid synthesis and promoting lipid oxidative decomposition, thereby reducing the fat content and cholesterol level in the product.
Furthermore, the animal meat is obtained by taking linolenic acid and fucoxanthin and/or fucoxanthin into animals. The DHA content in the muscle is limited, and the fucoxanthin and/or the fucoxanthin alcohol are/is added on the basis of using the linolenic acid, so that a better effect can be obtained, the fat content and the cholesterol level are reduced, and the nutritional quality of the animal meat is improved.
Further, when the animals take linolenic acid and fucoxanthin and/or fucoxanthin alcohol, the addition amount of the linolenic acid is 0.2 to 2 percent of the feed; the addition amount of fucoxanthin or fucoxanthin alcohol is 20-300mg/kg of the feed. Fucoxanthin or fucoxanthin: the ratio of linolenic acid is 0.001-0.15 to improve DHA level.
Furthermore, the linolenic acid is linolenic acid or oil rich in linolenic acid, such as one of linseed oil and perilla seed oil.
Further, the product is a food, a medicine, a health product or a dietary supplement.
The invention has the beneficial effects that:
(1) the application of the product in improving DHA level in human body is provided, namely, the DHA content in animal muscle is improved through fucoxanthin and/or fucoxanthin alcohol, and the combination of the fucoxanthin and/or fucoxanthin alcohol and linolenic acid is provided according to the mechanism of the DHA content in the animal muscle to promote DHA deposition in the animal muscle, so that the nutritional value of meat products is improved, and the dietary supplement source of DHA is expanded.
(2) Provides a method for improving DHA content of animal muscle, can realize stable, efficient and healthy DHA deposition in meat products through biotransformation, and has wider application range.
(3) Provides a mode for improving the DHA content of muscle, reducing animal fat and cholesterol level in meat, thereby improving the quality of meat products.
Drawings
FIG. 1: DHA content comparison in six groups of chicken meat on day 10 supplemented with fucoxanthin.
FIG. 2: control of abdominal fat rate in four groups of chicken on day 10 supplemented with fucoxanthin.
FIG. 3: cholesterol content in four groups of chicken was compared on day 10 with fucoxanthin supplementation.
FIG. 4: DHA content comparison in six groups of chicken meat on day 10 supplemented with fucoxanthin.
FIG. 5: fucoxanthin-supplemented chicken fat ratios in four groups on day 10 were compared.
FIG. 6: cholesterol content in four groups of chicken was compared on day 10 with fucoxanthin supplementation.
FIG. 7: DHA content comparison in six groups of pork at day 30 supplemented with fucoxanthin.
FIG. 8: fat content comparison in four groups of pork on day 30 supplemented with fucoxanthin.
FIG. 9: and (5) supplementing fucoxanthin, and comparing the cholesterol content in the pork of the four groups on the 30 th day.
FIG. 10: and comparing the DHA content of the pork of six groups on the 30 th day after fucoxanthin supplementation.
FIG. 11: fat content comparison in four pork groups on day 30 after supplementation with fucoxanthin.
FIG. 12: and supplementing fucoxanthin, and comparing the cholesterol content in the pork of the four groups on the 30 th day.
The specific implementation mode is as follows:
in order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are a part of the embodiments of the present invention, but not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1:
70 white feather broilers of 20 days old with the average body weight of 1100 +/-5 g are collected and randomly divided into 7 groups, and 10 broilers in each group are respectively fed with basic corn-soybean meal feed, feed added with 0.5% (w/w) of linolenic acid (the addition amount of linseed oil is 1%, the content of linolenic acid in linseed is 50%), feed added with 0.5% of linolenic acid and supplemented with 0.02% of fucoxanthin, feed added with 0.5% of linolenic acid and supplemented with 0.03% of fucoxanthin, feed added with 1% of linolenic acid and supplemented with 0.02% of fucoxanthin, and feed added with 1% of linolenic acid and supplemented with 0.03% of fucoxanthin. The test process adopts a single cage and single feeding mode, and the feeding and drinking are free. Continuously illuminating for 24h, keeping the illumination intensity at night until normal diet is available, and well ventilating and cleaning. After feeding for 10 days, the muscles and abdominal fat are slaughtered.
The experimental method comprises the following steps: lipid extraction of broiler muscle was performed by the method of Floch et al, the obtained lipid was subjected to methyl esterification treatment with methyl esterification reagent (hydrochloric acid: methanol 1: 5, v/v), and the sample was extracted with n-hexane and subjected to gas phase analysis.
Gas chromatography conditions: an Agilent GC7820A gas chromatograph equipped with a hydrogen flame ion detector; the chromatographic column was an HP-INNOWWax quartz capillary column (30 m.times.320 μm.times.0.25 μm) and the carrier gas was high purity nitrogen.
Quantification is performed based on the principle that the response of the detector to the analyte is proportional to the amount of the analyte. The peaks in the sample spectra were integrated and the fatty acid detection was performed as C15: 0 is an internal standard and each fatty acid composition is expressed as a percentage of its total fatty acid content. The cholesterol content in the muscle is calculated according to the amount of the internal standard by taking 5 alpha-cholestane as the internal standard.
The gas phase analysis result shows that only trace DHA (< 0.5%) can be detected in the muscles of the broiler fed with the basic feed, and the DHA content in the muscles can be improved by supplementing ALA.
The DHA content in chicken is shown in figure 1, and after feeding for 10 days, the DHA content in chicken can be increased under both contents after the feed is supplemented with ALA. Indicating that the addition of ALA to the feed can be converted to DHA and deposited in the muscle. Compared with the feed supplemented with 0.5% and 1% of linolenic acid alone, the feed added with 0.02% of fucoxanthin can respectively improve the DHA content in chicken meat by 25% and 18%; the addition of 0.03% of fucoxanthin in the feed can respectively increase the DHA content in chicken meat by 31% and 18.5%, and the results are statistically significant. The fucoxanthin can be proved to be capable of obviously improving the DHA level in the muscle; and the result of obviously increasing the DHA content can be obtained by only feeding for 10 days, which shows that the feed has better effect by short-term feeding.
Fig. 2 shows the results of the abdominal fat percentage (abdominal fat weight/live weight × 100%) in chicken, and compared with the control group, the abdominal fat percentage (5%) in chicken was decreased by feeding ALA feed, while the abdominal fat percentage in the group to which 0.02% and 0.03% fucoxanthin were added was decreased by 14% and 20%, respectively, and the results were statistically significant.
FIG. 3 shows the results of cholesterol content in chicken, compared with the control group, the group fed with only ALA feed had no significant difference in cholesterol content, while the groups fed with 0.02% and 0.03% fucoxanthin had the cholesterol content respectively decreased by 6% and 10%, and the results were statistically significant.
Example 2:
70 white feather broilers of 20 days old with the average weight of 1100 +/-5 g are collected and randomly divided into 7 groups, 10 broilers in each group are respectively fed with basic corn-soybean meal feed, feed added with 0.5% (w/w) of linolenic acid (the addition amount of the flaxseed is 1%, the content of the linolenic acid in the flaxseed is 50%), feed added with 0.5% of the linolenic acid and supplemented with 0.02% of fucoxanthin, feed added with 0.5% of the linolenic acid and supplemented with 0.03% of the fucoxanthin, feed added with 1% of the linolenic acid and supplemented with 0.02% of the fucoxanthin, and feed added with 1% of the linolenic acid and supplemented with 0.03% of the fucoxanthin. The test process adopts a single cage and single feeding mode, and the feeding and drinking are free. Continuously illuminating for 24h, keeping the illumination intensity at night until normal diet is available, and well ventilating and cleaning. After feeding for 10 days, the muscles and abdominal fat are slaughtered.
FIG. 4 is a graph of DHA percentage content in chicken, and compared with the way of independently supplementing 0.5% and 1% of linolenic acid, the DHA content in chicken can be respectively increased by 27% and 18.8% by adding 0.02% of fucoxanthin into the feed; the addition of 0.03% of fucoxanthin in the feed can respectively improve the DHA content in chicken meat by 33% and 20%, and the results are statistically significant.
Fig. 5 shows the results of the abdominal fat percentage (abdominal fat weight/live weight × 100%) in chicken, and compared with the control group, the abdominal fat percentage in chicken was decreased by feeding ALA feed, while the abdominal fat percentage in the group to which 0.02% and 0.03% fucoxanthin were added was decreased by 15% and 22%, respectively, and the results were statistically significant.
FIG. 6 shows the results of cholesterol content in chicken, compared with the control group, the group fed with only ALA feed had no significant difference in cholesterol content, while the groups fed with 0.02% and 0.03% fucoxanthin had the cholesterol content respectively decreased by 6% and 10.8%, and the results were statistically significant.
Example 3:
56 healthy white pigs weighing about 65kg are selected and randomly divided into 7 groups according to the principle of similar weight, each group comprises 8 pigs, and the feed is respectively fed with basic corn-soybean meal feed, feed added with 0.5% (w/w) of linolenic acid (the addition amount of the flaxseed is 1%, the content of the linolenic acid in the flaxseed is 50%), feed added with 0.5% of the linolenic acid and supplemented with 0.02% of the fucoxanthin, feed added with 0.5% of the linolenic acid and supplemented with 0.03% of the fucoxanthin, feed added with 1% of the linolenic acid and supplemented with 0.02% of the fucoxanthin, and feed added with 1% of the linolenic acid and supplemented with 0.03% of the fucoxanthin. During the test, the pigs eat and drink water freely, ventilation and cleaning work are well done, and the feeding period is 30 days.
FIG. 7 is a graph showing the percentage content of DHA in pork, and compared with the case of separately supplementing linolenic acid in an amount of 0.5% and 1%, the DHA content in pork can be increased by 22% and 17% by adding fucoxanthin into the feed in an amount of 0.02%; the content of DHA in pork can be respectively increased by 31% and 21% by adding 0.03% of fucoxanthin into the feed, and the results are statistically significant.
FIG. 8 is a graph showing the fat content in pork, and compared with the control group, the fat content in pork was decreased by feeding ALA feed, while the fat content in the group to which 0.02% and 0.03% fucoxanthin were added was decreased by 7% and 12%, respectively, and the results were statistically significant.
Fig. 9 shows the results of cholesterol content in pork, compared with the control group, there was no significant difference in cholesterol content in the group fed with ALA feed alone, while the groups fed with 0.02% and 0.03% fucoxanthin were reduced in cholesterol content by 5% and 11%, respectively, and the results were statistically significant.
Example 4:
56 healthy white pigs weighing about 65kg are selected and randomly divided into 7 groups according to the principle of similar weight, each group comprises 8 pigs, and the feed is respectively fed with basic corn-soybean meal feed, feed added with 0.5% (w/w) of linolenic acid (the addition amount of the flaxseed is 1%, the content of the linolenic acid in the flaxseed is 50%), feed added with 0.5% of the linolenic acid and supplemented with 0.02% of fucoxanthin, feed added with 0.5% of the linolenic acid and supplemented with 0.03% of the fucoxanthin, feed added with 1% of the linolenic acid and supplemented with 0.02% of the fucoxanthin, and feed added with 1% of the linolenic acid and supplemented with 0.03% of the fucoxanthin. During the test, the pigs eat and drink water freely, ventilation and cleaning work are well done, and the feeding period is 30 days.
FIG. 10 is a graph showing the percentage content of DHA in pork, and compared with the case where linolenic acid is separately supplemented by 0.5% and 1%, the DHA content in pork can be increased by 23% and 17.2% by adding fucoxanthin in the feed in an amount of 0.02%; the addition of 0.03% of fucoxanthin in the feed can respectively improve the DHA content in pork by 33% and 20.5%, and the results are statistically significant.
FIG. 11 is a graph showing the fat content in pork, and compared with the control group, the fat content in pork was reduced by feeding ALA feed, while the fat content in the group to which 0.02% and 0.03% fucoxanthin were added was reduced by 7.5% and 13%, respectively, and the results were statistically significant.
Fig. 12 shows the results of cholesterol content in pork, compared with the control group, there was no significant difference in cholesterol content in the group fed with ALA feed alone, while the cholesterol content in the group fed with 0.02% and 0.03% fucoxanthin was reduced by 6.8% and 11.5%, respectively, and the results were statistically significant.
In conclusion, on the basis of ALA, fucoxanthin or fucoxanthin can increase the DHA content in muscle and simultaneously reduce the lipid content and cholesterol level in meat. Therefore, the fucoxanthin or the fucoxanthin and the linolenic acid are matched to produce poultry meat or livestock meat products with rich DHA, low fat and low cholesterol level, and products for improving the DHA level in human bodies can be prepared by utilizing the products, and the human bodies can take sufficient DHA by taking the products.
Claims (7)
1. The application of the fucoxanthin andor the fucoxanthin alcohol in the product for improving the DHA level in the human body is characterized in that: the product is made from animal meat with high DHA content; the animal meat is obtained by taking fucoxanthin and/or fucoxanthin into animals.
2. The use of claim 1, wherein: use of fucoxanthin and/or fucoxanthin in reducing fat and cholesterol levels in a product.
3. Use according to claim 1 or 2, characterized in that: the animal meat is obtained by taking linolenic acid and fucoxanthin and/or fucoxanthin into animals.
4. Use according to claim 3, characterized in that: the intake ratio of fucoxanthin and/or fucoxanthin to linolenic acid is 0.001-0.15.
5. The use of claim 4, wherein: the intake of linolenic acid is 0.2% -2% of the feed; the intake of fucoxanthin or fucoxanthin alcohol is 20-300mg/kg of the feed.
6. Use according to claim 3, characterized in that: the linolenic acid is one of linolenic acid or linseed oil and perilla seed oil.
7. Use according to claim 1 or 2, characterized in that: the product is a medicine, health product, food or dietary supplement.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117180256A (en) * | 2023-07-17 | 2023-12-08 | 德默特生物科技(珠海)有限公司 | Application of fucoxanthin in preparation of medicine for improving myocardial structure reconstruction and electrophysiological reconstruction after myocardial infarction |
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| WO2008053517A1 (en) * | 2006-10-30 | 2008-05-08 | National University Corporation Hokkaido University | Agent for promoting in vivo dha synthesis and seaweed oil |
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| CN117180256A (en) * | 2023-07-17 | 2023-12-08 | 德默特生物科技(珠海)有限公司 | Application of fucoxanthin in preparation of medicine for improving myocardial structure reconstruction and electrophysiological reconstruction after myocardial infarction |
| CN117180256B (en) * | 2023-07-17 | 2024-03-08 | 德默特生物科技(珠海)有限公司 | Application of fucoxanthin in preparation of medicine for improving myocardial structure reconstruction and electrophysiological reconstruction after myocardial infarction |
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