CN112638922B - 金(iii)配合物、其缀合物、包含其的药物组合物以及用途和制备其的方法 - Google Patents

金(iii)配合物、其缀合物、包含其的药物组合物以及用途和制备其的方法 Download PDF

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CN112638922B
CN112638922B CN201980037344.0A CN201980037344A CN112638922B CN 112638922 B CN112638922 B CN 112638922B CN 201980037344 A CN201980037344 A CN 201980037344A CN 112638922 B CN112638922 B CN 112638922B
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iii
gold
complex
pharmaceutically acceptable
independently selected
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Chinese (zh)
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CN112638922A (zh
Inventor
S·M·索托·冈萨雷斯
C·拉蒂亚·隆坎
V·塞帕斯·洛佩斯
Y·洛佩斯·库维略斯
F·洛佩斯·奥尔蒂斯
M·J·伊格莱西亚斯·巴尔德斯-索利斯
R·M·冈萨雷斯·森加斯
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Private Foundation Of Institute For Global Health In Barcelona
University Almeria
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Private Foundation Of Institute For Global Health In Barcelona
University Almeria
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/12—Gold compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having alternatively specified atoms bound to the phosphorus atom and not covered by a single one of groups A01N57/10, A01N57/18, A01N57/26, A01N57/34
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having alternatively specified atoms bound to the phosphorus atom and not covered by a single one of groups A01N57/10, A01N57/18, A01N57/26, A01N57/34
    • A01N57/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having alternatively specified atoms bound to the phosphorus atom and not covered by a single one of groups A01N57/10, A01N57/18, A01N57/26, A01N57/34 containing heterocyclic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/67—Phosphorus compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5463—Compounds of the type "quasi-phosphonium", e.g. (C)a-P-(Y)b wherein a+b=4, b>=1 and Y=heteroatom, generally N or O
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
CN201980037344.0A 2018-05-03 2019-04-29 金(iii)配合物、其缀合物、包含其的药物组合物以及用途和制备其的方法 Active CN112638922B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18382305.3A EP3564246B1 (en) 2018-05-03 2018-05-03 A gold(iii) complex, a conjugate of the gold(iii) complex, a pharmaceutical composition comprising the gold(iii) complex and uses and a process for preparing the gold(iii) complex
EP18382305.3 2018-05-03
PCT/EP2019/060879 WO2019211222A1 (en) 2018-05-03 2019-04-29 A gold(iii) complex, a conjugate of the gold(iii) complex, a pharmaceutical composition comprising the gold(iii) complex and uses and a process for preparing the gold(iii) complex

Publications (2)

Publication Number Publication Date
CN112638922A CN112638922A (zh) 2021-04-09
CN112638922B true CN112638922B (zh) 2024-04-05

Family

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CN201980037344.0A Active CN112638922B (zh) 2018-05-03 2019-04-29 金(iii)配合物、其缀合物、包含其的药物组合物以及用途和制备其的方法

Country Status (10)

Country Link
US (1) US11866455B2 (https=)
EP (1) EP3564246B1 (https=)
JP (1) JP7499755B2 (https=)
KR (1) KR20210008020A (https=)
CN (1) CN112638922B (https=)
CA (1) CA3098778A1 (https=)
DK (1) DK3564246T3 (https=)
ES (1) ES2893849T3 (https=)
MX (1) MX2020011557A (https=)
WO (1) WO2019211222A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022072545A1 (en) * 2020-09-29 2022-04-07 University Of Kentucky Research Foundation Multi-coordinate gold-phosphine compounds and methods of use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040108A1 (en) * 1995-06-07 1996-12-19 Washington University Multidentate metal complexes and methods of making and using thereof
WO2013091014A1 (en) * 2011-12-22 2013-06-27 James Cook University Antimicrobial agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0900961D0 (en) * 2009-01-20 2009-03-04 Univ Bath Antimicrobial coating

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040108A1 (en) * 1995-06-07 1996-12-19 Washington University Multidentate metal complexes and methods of making and using thereof
WO2013091014A1 (en) * 2011-12-22 2013-06-27 James Cook University Antimicrobial agents

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Cycloaurated Phosphinothioic Amide Complex as a Precursor of Gold(I) Nanoparticles: Efficient Catalysts for A3 Synthesis of Propargylamines under Solvent-Free Conditions;Eva Belmonte Sánchez et al.;《Organometallics》;第36卷;第1962-1973页 *
Gold(III) Complexes Activity against Multidrug-Resistant Bacteria of Veterinary Significance;Carlos Ratia et al.;《antibiotics》;第11卷;第1728页 *
Synthesis of Apoptosis-Inducing Iminophosphorane Organogold(III) Complexes and Study of Their Interactions with Biomolecular Targets;Neha Shaik et al.;《Inorganic Chemistry》;第48卷(第4期);第1577-1587页 *
金团簇的分析研究进展;代蕊 等;《应用化工》;第46卷(第10期);第2005-2009页 *

Also Published As

Publication number Publication date
EP3564246B1 (en) 2021-07-07
JP2021523936A (ja) 2021-09-09
ES2893849T3 (es) 2022-02-10
JP7499755B2 (ja) 2024-06-14
CA3098778A1 (en) 2019-11-07
KR20210008020A (ko) 2021-01-20
US11866455B2 (en) 2024-01-09
BR112020022402A2 (pt) 2021-02-02
DK3564246T3 (da) 2021-08-09
MX2020011557A (es) 2021-01-29
US20210188886A1 (en) 2021-06-24
EP3564246A1 (en) 2019-11-06
CN112638922A (zh) 2021-04-09
WO2019211222A1 (en) 2019-11-07

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