CN112634981B - Data processing device and method for data fixed placement - Google Patents
Data processing device and method for data fixed placement Download PDFInfo
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- 238000012545 processing Methods 0.000 title claims abstract description 76
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- 229920000642 polymer Polymers 0.000 claims abstract description 69
- 238000004891 communication Methods 0.000 claims abstract description 12
- 239000012429 reaction media Substances 0.000 claims description 51
- 108020004414 DNA Proteins 0.000 claims description 28
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- 238000011010 flushing procedure Methods 0.000 claims description 20
- 239000002105 nanoparticle Substances 0.000 claims description 14
- 238000003672 processing method Methods 0.000 claims description 13
- 238000002360 preparation method Methods 0.000 claims description 11
- 239000000427 antigen Substances 0.000 claims description 7
- 102000036639 antigens Human genes 0.000 claims description 7
- 108091007433 antigens Proteins 0.000 claims description 7
- 230000027455 binding Effects 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 238000000108 ultra-filtration Methods 0.000 claims description 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 5
- 239000011521 glass Substances 0.000 claims description 4
- 238000005119 centrifugation Methods 0.000 claims description 3
- 230000009870 specific binding Effects 0.000 claims description 3
- 238000004364 calculation method Methods 0.000 abstract description 3
- 238000000354 decomposition reaction Methods 0.000 abstract description 3
- 239000000523 sample Substances 0.000 description 62
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- 102000053602 DNA Human genes 0.000 description 7
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Abstract
The invention provides a data processing device and a method for data fixed placement, wherein the device comprises: the device comprises a processing instruction input module, a controller, a first container, a second container, a third container, a fourth container, a fifth container, a first switch connected on a communication path between the first container and the fifth container, a second switch connected on a communication path between the second container and the fifth container, a third switch connected on a communication path between the third container and the fifth container, a fourth switch connected on a communication path between the fourth container and the fifth container, and a detector connected between the controller and the fifth container. According to the device and the method provided by the invention, any third reactant can directly react with the specific second reactant fixed by the first reactant in parallel, the second reactants with a longer physical distance cannot be connected into a polymer through the third reactant, so that the condition of non-true decomposition of the second polymer can be effectively reduced, and the solution efficiency and the calculation accuracy of NP-difficult problems are improved.
Description
Technical Field
The present invention relates to the field of data processing technologies, and in particular, to a data processing device and method for data fixed placement.
Background
As the core of information processing, the computer is not only a main tool for promoting social progress, but also an important sign for measuring the civilization degree of human society.
Unfortunately, electronic computers cannot effectively handle NP-complete problems such as scheduling problems, protein structure predictions, password cracking, circuit routing, partitioning of graphs, etc., and the number of required operations increases exponentially with increasing problem size, i.e., the required operation time of the electronic computer increases explosively. Therefore, a new data processing method is needed to improve the data processing efficiency and the accuracy of the processing result of NP-complete problems.
Disclosure of Invention
The invention provides a data processing device and a data processing method for data fixed placement, which are used for solving the defect that the NP-complete problem cannot be efficiently solved in the prior art.
The invention provides a data processing device for data fixed placement, comprising:
A processing instruction input module, a controller, a first container, a second container, a third container, a fourth container, a fifth container, a first switch connected to the first container and the fifth container communication path, a second switch connected to the second container and the fifth container communication path, a third switch connected to the third container and the fifth container communication path, a fourth switch connected to the fourth container and the fifth container communication path, and a detector connected between the controller and the fifth container;
The processing instruction input module is connected with the controller, and the controller is connected with the first switch, the second switch, the third switch and the fourth switch;
The controller is used for sending a first instruction to the first switch according to the processing instruction input by the processing instruction input module, so that a first reactant pre-stored in the first container enters a fifth container and is connected with the bottom fixed position of the fifth container; after reaching a first preset time, the controller sends a second instruction to the second switch, so that a second reactant pre-stored in the second container enters the fifth container, and sends a fourth instruction to the fourth switch Guan Fasong, so that a reaction medium pre-stored in the fourth container enters the fifth container, and the first reactant and the second reactant react under the action of the reaction medium to generate a first polymer; after reaching a second preset time, the controller controls the fifth container to remove unreacted first reactant and second reactant in the fifth container in a flushing mode; after reaching a third preset time, the controller sends a third instruction to the third switch, so that a third reactant pre-stored in the third container enters the fifth container, and sends a fourth instruction to the fourth switch Guan Fasong, so that a reaction medium pre-stored in the fourth container enters the fifth container, and the first polymer and the third reactant react under the action of the reaction medium to generate a second polymer; after reaching the fourth preset time, the controller controls the fifth container to remove unreacted reactants in a flushing mode, then controls the detector to detect the second polymer, and determines whether the second polymer is true solution of the problem to be solved according to the detection result.
According to the data processing device for fixedly placing the data, the second reactant is manufactured according to the data to be processed and the connection relation between the data to be processed; the first reactant and the third reactant are reactants which are made according to the second reactant and matched with the second reactant.
The invention provides a data processing device for fixedly placing data, which also comprises a data acquisition device and a reactant manufacturing device, wherein the data acquisition device and the reactant manufacturing device are connected with a controller;
The data acquisition device is used for acquiring data to be processed and sending the data to be processed to the controller;
the controller is used for sending a reactant preparation instruction to the reactant preparation device according to the data to be processed and the connection relation between the data to be processed;
the reactant preparation device is used for preparing the first reactant, the second reactant and the third reactant according to the reactant preparation instruction.
According to the data processing device for data fixation and placement provided by the invention, the second reactant consists of nano particles and a plurality of DNA single chains connected to the nano particles, and the DNA single chains of the same kind are arranged on the same area of the nano particles; the first reactant and the third reactant are DNA single strands; the plurality of DNA single strands are DNA single strands having a plurality of DNA sequences.
According to the data processing device for data fixed placement, the bottom of the fifth container is provided with a plurality of identical subregions, each subregion comprises a plurality of connecting sites, the connecting sites are used for connecting a first reactant entering the fifth container so as to enable the first reactant to be fixedly placed, and the first reactant is matched with the connecting sites.
According to the data processing device for data fixation and placement provided by the invention, the first reactant is specifically bound with the fixed position at the bottom of the fifth container, the first reactant is modified by an antibody, the connecting site is modified by an antigen, and the specific binding is realized by combining the antigen and the antibody.
According to the data processing device for data fixation and placement provided by the invention, the reaction medium prestored in the fourth container is polymerase.
According to the data processing device for data fixed placement, which is provided by the invention, the flushing mode is an ultrafiltration centrifugal mode.
According to the data processing device for fixedly placing the data, the fifth container is a PE container or a glass container; the detector is an atomic force microscope AFM or a scanning electron microscope.
The invention also provides a data processing method of the data processing device based on any one of the data fixed placement, which comprises the following steps:
The processing instruction input module inputs a processing instruction to the controller;
The controller sends a first instruction to the first switch according to the processing instruction, so that a first reactant pre-stored in the first container enters a fifth container and is connected with the fixed position of the bottom of the fifth container; after reaching a first preset time, the controller sends a second instruction to the second switch, so that a second reactant pre-stored in the second container enters the fifth container, and sends a fourth instruction to the fourth switch Guan Fasong, so that a reaction medium pre-stored in the fourth container enters the fifth container, and the first reactant and the second reactant react under the action of the reaction medium to generate a first polymer; after reaching a second preset time, the controller controls the fifth container to remove unreacted first reactant and second reactant in the fifth container in a flushing mode; after reaching a third preset time, the controller sends a third instruction to the third switch, so that a third reactant pre-stored in the third container enters the fifth container, and sends a fourth instruction to the fourth switch Guan Fasong, so that a reaction medium pre-stored in the fourth container enters the fifth container, and the first polymer and the third reactant react under the action of the reaction medium to generate a second polymer; after reaching the fourth preset time, the controller controls the fifth container to remove unreacted reactants in a flushing mode, then controls the detector to detect the second polymer, and determines whether the second polymer is true solution of the problem to be solved according to the detection result.
According to the data processing method for fixedly placing the data, the second reactant is manufactured according to the data to be processed and the connection relation between the data to be processed;
when the graph problem is processed, the controller takes each data in the data to be processed as a vertex, and takes the connection relation between the data to be processed as an edge.
According to the data processing method for data fixed placement provided by the invention, the bottom of the fifth container is provided with a plurality of identical subregions, each subregion comprises a plurality of connecting sites, the connecting sites are used for connecting the first reactant entering the fifth container so as to enable the first reactant to be fixedly placed, and the number of connecting sites of each subregion is equal to the order of the graph.
According to the data processing device and the data processing method for the fixed placement of the data, in the process of one data processing, any third reactant can directly react with the specific second reactant fixed by the first reactant, and a large number of third reactants can react with the second reactant in parallel, so that the data processing efficiency is improved. In addition, the second reactants are fixed in the fifth container through the first reactants, so that the second reactants with a larger physical distance cannot be connected into a polymer through the third reactants, and the situation of non-true decomposition of the second polymer can be effectively reduced. In addition, the second reactant which is not fixed in the fifth container is washed after the first reactant reacts with the second reactant, so that the second reactant which is free to move in the space of the fifth container is not available, the obstruction encountered when the third reactant searches for the specific second reactant can be effectively reduced, and the solving efficiency and the calculating accuracy of the NP-difficult problem can be effectively improved.
Drawings
In order to more clearly illustrate the invention or the technical solutions of the prior art, the following description will briefly explain the drawings used in the embodiments or the description of the prior art, and it is obvious that the drawings in the following description are some embodiments of the invention, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of a data processing apparatus with data fixed placement according to the present invention;
FIG. 2 is a schematic diagram of the structure of data and data cells according to the present invention:
FIG. 3 is a schematic diagram of a data processing process according to the present invention;
FIG. 4 is a schematic flow chart of a data processing method according to the present invention;
FIG. 5 is a 6-stage 3-color chart provided by the present invention;
FIG. 6 is a schematic representation of a ligation site in a sub-region of a computing platform provided by the present invention;
FIG. 7 is a schematic diagram of a connection site connection data root in a computing platform subregion provided by the present invention;
FIG. 8 is a schematic representation of all the 3 possible 3-tints provided by the present invention.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings, and it is apparent that the described embodiments are some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
In general, an embodiment of the present invention provides a data processing apparatus, including: the device comprises a processing instruction input module, a controller, a first controllable switch, a second controllable switch, a third controllable switch, a fourth controllable switch, a first container, a second container, a third container, a fourth container, a fifth container and a detector.
Wherein, the first container is used for placing the first reactant, the second container is used for placing the second reactant, the third container is used for placing the third reactant, the fourth container is used for placing the reaction medium, and the fifth container is used as a reactant reaction platform; the detection end of the detector is arranged corresponding to the fifth container; the processing instruction input module is connected with the controller, the first container, the second container, the third container and the fourth container are all communicated with the fifth container, a first controllable switch is arranged on a connecting passage of the first container and the fifth container, a second controllable switch is arranged on a connecting passage of the second container and the fifth container, a third controllable switch is arranged on a connecting passage of the third container and the fifth container, a fourth controllable switch is arranged on a connecting passage of the fourth container and the fifth container, and the controller is respectively connected with the first controllable switch, the second controllable switch, the third controllable switch and the fourth controllable switch and is also connected with the detector; and the processing instruction input module is used for inputting the processing instruction to the controller.
The first controllable switch is used for being opened according to a first opening control instruction sent by the controller so as to enable a first reactant stored in the first container to enter the fifth container; the first reactant is prepared according to the second reactant and matched with the second reactant; the first reactant enters the fifth container and then is connected with the bottom of the container, so that the first polymer generated after the second reactant reacts with the first reactant is fixedly placed at the bottom of the fifth container.
The second controllable switch is used for being opened according to a second opening control instruction sent by the controller after the first preset time is reached, so that a second reactant stored in the second container in advance enters the fifth container to react with the first reactant under the action of a reaction medium to generate a first polymer; the second reactant is prepared according to the connection relation between the data to be processed and the data to be processed.
The third controllable switch is used for being opened according to a third opening control instruction sent by the controller after a third preset time is reached, so that a third reactant stored in the third container in advance enters the fifth container to react with the first polymer under the action of the reaction medium to generate a second polymer; the third reactant is made from the second reactant, and the third reactant matches the second reactant.
The fourth controllable switch is used for being opened according to a fourth opening control instruction sent by the controller after the first preset time is reached, so that a reaction medium stored in the fourth container in advance enters the fifth container; and the reaction medium is used for opening according to a fourth opening control instruction sent by the controller after the third preset time is reached, so that the reaction medium prestored in the fourth container enters the fifth container.
And the detector is used for detecting the second polymer in the fifth container according to the detection instruction sent by the controller so as to obtain a corresponding detection result and sending the detection result to the controller.
The controller is used for sending a first instruction to the first switch according to the processing instruction, so that a first reactant pre-stored in the first container enters the fifth container; after the first preset time is reached, the controller sends a second instruction to the second switch, so that a second reactant pre-stored in the second container enters the fifth container, and simultaneously sends a fourth instruction to the fourth switch Guan Fasong, so that a reaction medium pre-stored in the fourth container enters the fifth container, and the first reactant and the second reactant react under the action of the reaction medium to generate a first polymer; after reaching the second preset time, the controller controls the fifth container to remove unreacted first reactant and second reactant in the fifth container in a flushing mode; after reaching a third preset time, the controller sends a third instruction to the third switch, so that a third reactant pre-stored in the third container enters the fifth container, and simultaneously sends a fourth instruction to the fourth switch Guan Fasong, so that a reaction medium pre-stored in the fourth container enters the fifth container, and the first polymer and the third reactant react under the action of the reaction medium to generate a second polymer; after the fourth preset time is reached, the controller controls the fifth container to remove unreacted reactants in a flushing mode, then controls the detector to detect the second polymer, and determines whether the polymer is true solution of the problem to be solved according to the detection result. Wherein, the flushing mode can be an ultrafiltration centrifugal mode.
The device also comprises a data acquisition device and a reactant preparation device which are both connected with the controller; the data acquisition device is used for acquiring data to be processed and sending the data to be processed to the controller; the controller is used for sending a control instruction to the reactant preparation device according to the data to be processed and the connection relation between the data to be processed; and the reactant preparation device is used for preparing the first, second and third reactants according to the control instruction.
The second reactant is manufactured according to the connection relation between the data to be processed and the data to be processed; the first reactant is prepared according to the second reactant, and the first reactant is matched with the second reactant; the third reactant is made from the second reactant, and the third reactant matches the second reactant.
One implementation of the second reactant is a nanoparticle, and multiple DNA single strands are attached to the nanoparticle, wherein the same DNA single strand on the nanoparticle is attached to the same region of the nanoparticle; the first reactant and the third reactant are DNA single strands; the plurality of DNA single strands are DNA single strands having a plurality of DNA sequences; the first reactant and the single-stranded DNA of the second reactant are complementary to each other, so that matching is realized; the third reactant is complementary to the single-stranded DNA of the second reactant, i.e., a match is achieved.
The bottom of the fifth container is provided with a plurality of identical subregions, each subregion containing a plurality of connecting sites for connecting the first reactant entering the fifth container to be fixedly placed, and the first reactant is matched with the connecting sites. The first reactant may be specifically bound to the binding site by modifying the first reactant with an antibody and modifying the binding site with an antigen, the specific binding being achieved by binding the antigen to the antibody.
One specific implementation of the reaction medium is a polymerase. The fifth container and the sixth container may be PE containers or glass containers. The detector may be an atomic force microscope AFM or a scanning electron microscope.
Based on the data processing device, the invention also provides a corresponding data processing method, which comprises the following steps: the processing instruction input module inputs a processing instruction to the controller; the controller sends a first instruction to the first switch according to the processing instruction, so that a first reactant pre-stored in the first container enters the fifth container and is connected with the bottom of the fifth container; after the first preset time is reached, the controller sends a second instruction to the second switch, so that a second reactant pre-stored in the second container enters the fifth container, and a fourth instruction to the fourth switch Guan Fasong is sent, so that a reaction medium pre-stored in the fourth container enters the fifth container, and the first reactant and the second reactant react under the action of the reaction medium to generate a first polymer; after reaching the second preset time, the controller controls the fifth container to remove unreacted first reactant and second reactant in the fifth container in a flushing mode; after reaching a third preset time, the controller sends a third instruction to the third switch, so that a third reactant pre-stored in the third container enters the fifth container, and a fourth instruction to the fourth switch Guan Fasong, so that a reaction medium pre-stored in the fourth container enters the fifth container, and the first polymer and the third reactant react under the action of the reaction medium to generate a second polymer; after the fourth preset time is reached, the controller controls the fifth container to remove unreacted reactants in a flushing mode, then controls the detector to detect the second polymer, and determines whether the polymer is true solution of the problem to be solved according to the detection result.
When the data processing method is used for processing the graph problem, the controller takes each data in the data to be processed as a vertex, and takes the connection relation between the data to be processed as an edge.
The bottom of the fifth vessel may be provided with a plurality of identical sub-regions, each sub-region comprising a plurality of connection sites for connecting the first reactant into the fifth vessel for a fixed placement thereof, each sub-region having a number of connection sites equal to the order of the figure.
Specifically, fig. 1 is a schematic structural diagram of a data processing device for data fixed placement according to an embodiment of the present invention, as shown in fig. 1, where the device includes: a processing instruction input module 11, a controller 12, a first container 13, a second container 14, a third container 15, a fourth container 16, a fifth container 17, a detector 18, a first controllable switch 19, a second controllable switch 20, a third controllable switch 21, and a fourth controllable switch 22.
Wherein, the first container 13 is used for placing the first reactant, the second container 14 is used for placing the second reactant, the third container 15 is used for placing the third reactant, the fourth container 16 is used for placing the reaction medium, and the fifth container 17 is used as a reactant reaction platform; the detection end of the detector 18 is arranged corresponding to the fifth container 17; the processing instruction input module 11 is connected with the controller 12, the first container 13, the second container 14, the third container 15 and the fourth container 16 are all communicated with the fifth container 17, a first controllable switch 19 is arranged on a connecting path of the first container 13 and the fifth container 17, a second controllable switch 20 is arranged on a connecting path of the second container 14 and the fifth container 17, a third controllable switch 21 is arranged on a connecting path of the third container 15 and the fifth container 17, a fourth controllable switch 22 is arranged on a connecting path of the fourth container 16 and the fifth container 17, the controller 12 is respectively connected with the first controllable switch 19, the second controllable switch 20, the third controllable switch 21 and the fourth controllable switch 22, and the controller 12 is also connected with the detector 18.
A processing instruction input module 11 for inputting processing instructions to the controller 12.
A first controllable switch 19 for being opened according to a first opening control instruction sent from the controller 12 to allow the first reactant stored in advance in the first container 13 to enter the fifth container 17; the first reactant is prepared according to the second reactant and matched with the second reactant; the first reactant enters the fifth container and is connected with the fixed position at the bottom of the container, so that the first polymer generated after the second reactant reacts with the first reactant is also connected with the fixed position at the bottom of the fifth container.
The second controllable switch 20 is configured to be turned on according to a second turn-on control instruction sent by the controller 12 after the first preset time is reached, so that the second reactant stored in advance in the second container 14 enters the fifth container 17 to react with the first reactant under the action of the reaction medium to generate a first polymer; the second reactant is prepared according to the connection relation between the data to be processed and the data to be processed.
A third controllable switch 21, configured to be opened according to a third opening control instruction sent by the controller 12 after a third preset time is reached, so that a third reactant stored in advance in the third container 15 enters the fifth container 17 to react with the first polymer under the action of the reaction medium to generate a second polymer; the third reactant is made from the second reactant, and the third reactant matches the second reactant.
A fourth controllable switch 22, configured to be opened according to a fourth opening control instruction sent by the controller 12 after reaching a first preset time, so as to enable the reaction medium stored in the fourth container 16 to enter the fifth container 17; and is adapted to be opened according to a fourth opening control command sent from the controller after a third preset time is reached, so that the reaction medium stored in advance in the fourth vessel 16 enters the fifth vessel 17.
And a detector 18 for detecting the second polymer in the fifth container 17 according to the detection instruction sent by the controller 12 to obtain a corresponding detection result, and sending the detection result to the controller 12.
A controller 12 for sending a first command to the first switch 19 according to the processing command, so that the first reactant pre-stored in the first container 13 enters the fifth container 17; after reaching the first preset time, the controller 12 sends a second instruction to the second switch 20 to enable a second reactant pre-stored in the second container 14 to enter the fifth container 17, and simultaneously sends a fourth instruction to the fourth switch 22 to enable a reaction medium pre-stored in the fourth container 16 to enter the fifth container 17, and the first reactant and the second reactant react under the action of the reaction medium to generate a first polymer; after reaching the second preset time, the controller 12 controls the fifth container 17 to remove the unreacted first reactant and second reactant in the fifth container 17 in a flushing manner; after reaching the third preset time, the controller 12 sends a third instruction to the third switch 21 to enable a third reactant pre-stored in the third container 15 to enter the fifth container 17, and simultaneously sends a fourth instruction to the fourth switch 22 to enable a reaction medium pre-stored in the fourth container 16 to enter the fifth container 17, so that the first polymer and the third reactant react under the action of the reaction medium to generate a second polymer; after reaching the fourth preset time, the controller 12 controls the fifth container 17 to remove unreacted reactants in a flushing manner, and then controls the detector 18 to detect the second polymer, and determines whether the polymer is true solution of the problem to be solved according to the detection result. Wherein, the flushing mode can be an ultrafiltration centrifugal mode.
The first container 13, the second container 14, the third container 15, the fourth container 16, the fifth container 17 and the detector 18 are described below.
The second container 14 is used to store data to be processed, i.e., a second reactant, which may be referred to as a database, designated as X.
Database X may contain a number of non-empty subsets X 1,X2,…,Xn, each subset X i being referred to as a data pool of X, each data pool storing only one type of data X i. Data x i is made up of two parts: one is called a data cell and the other is called a data fiber. Only one data cell; the data fibers have p i(0＜pi which is less than or equal to n) and can be respectively marked asWherein each data fiber contains a large number of identical copies of the data. The data cells are connected with the data fibers, and the data fibers of the same kind are connected in the same area. A schematic diagram of the structure of the data x i is shown on the left side of fig. 2, in which a small sphere is used to represent the data cells, and one region of the sphere is shown on the right side of fig. 2 to represent the same type of data fiber, and different types of lines are shown on different types of data fibers.
The fifth container 15 is used to hold an operator, i.e. a third reactant, which may be referred to as a probe pool, denoted Y.
Probes in a probe library are "adhesives" used to find and correlate two data, defined exactly as follows.
Is provided withAnd/>Is a data fiber on two different kinds of data,/>And/>The probe in between, designated/>Refers to an operator (also referred to as a probe operator) that satisfies the following 3 conditions:
Can accurately find/>, in a computing platform lambda And/>This condition is referred to as adjacency;
can only be found in computing platform lambda And/>This condition is referred to as uniqueness;
The two data fibers can be found and simultaneously can be operated with certain attribute (such as connection, information transmission function and the like), and the action result is expressed as/> This condition is referred to as probeability.
If two data fibers in the databaseAnd/>Between which there is a probe/>Then call/>And/>Is probed, and corresponding data x l and x t are referred to as probed, and/>And/>Called probe/>Is a probe object of (2); otherwise, call/>And (3) withIs not probeable and is referred to as x l and x t are not probeable. The probe library consists of several probe sub-libraries, each of which stores only all possible probes between the specified two data.
According to the different problems, the probe operation with different attributes can be given, and correspondingly, the types of the data and the probes are also different, such as connection type data and transmission type data, connection type probes and transmission type probes, and the like.
Two probeable data fibersAnd/>Connected probe operator/>Meaning that two destination data fibers can be found on a computing platform/>And/>And a probe operator that can join the two fibers together, also referred to as/>
Two data x i and x t are shown in FIG. 3, anAnd/>Is the join operator/>Is a schematic diagram of (a). /(I)Can be regarded as data fiber/>Outer half with data fiber/>A complement of the outer half synthesis of (2) having an adsorption linkage/>And/>So that it can/>, the two data fibersAnd/>Connected together, data x i is naturally connected together with x t. The result after the action of this join operator is recorded as/> Representing data x i and x t through their fibers/>And/>Between probe operators/>And (3) a polymer formed by connecting the two components together after the action.
The fourth container 16 stores a specific solution (e.g., a polymerase) for free contact reaction of the data with the probe, i.e., a reaction medium, to assist in: the first reactant is connected to the bottom of the fifth container, the first reactant reacts with the second reactant to form a first polymer, and the first polymer reacts with the third reactant to form a second polymer. It should be noted that the first aggregate is formed by connecting a single data and a single data root, and the data on the first aggregate can be subjected to probe operation with the data on other first aggregates under the action of a specific probe.
The fifth container 17 is used to provide an environment for performing probe operations between data, and may be referred to as a computing platform.
The polymer formed by two data or a first polymer after the probe operation together with the corresponding probe is referred to as a 2-data polymer. Further, if the third data or any one of the first aggregate and the 2-data aggregate can be probed, the aggregate after the probe operation is called a 3-data aggregate. Similarly, an aggregate containing M (. Gtoreq.2) data after several probe operations is referred to as an M-data aggregate, or a data aggregate having an order of M, and is generally represented by M or M i with a subscript, and represents the order of M by |M|. In particular, one data is referred to as a 1-data aggregate.
The computing platform, denoted λ, has 3 basic functions:
Basic function 1: high polymerizability. When a certain probe When entering lambda,/>Two data fibers of interest/>, which are capable of producing higher order data polymers containing more probes, are always soughtAnd/>The following selection cases are specific:
If M 1,M2,M3 is 3 data polymers in λ, M 1 contains And M 2 and M 3 each contain/> And/>Is probed, when |M 2|＞|M3 |, then/>Will choose/>, on M 1 And/>, in M 2 Performing probe operation;
If it is Both data polymers M 1 and M 2 can be probed, and when |M 1|＞|M2 |, then/>Selecting M 2 to perform probe operation; if the number of probes is M 1|＝|M2, selecting one with the largest number of probes to implement probe operation; if |M 1|＝|M2 | and their number of probes is also the same, one is optional.
Basic function 2: uniqueness. For any data aggregate M in lambda, the types of the contained data are different from each other, and at most, the basic probe operation is carried out between any two data on M.
Basic function 3: threshold performance. After the data aggregate in λ is subjected to the probe operation, the order thereof needs to be exactly equal to the order of the probe operation map G (X′,Y′), and the number of probe operations needs to be exactly equal to |e (G (X′,Y′)) |. Thus, if the sum of the orders of the two polymers is greater than the order of G (X′,Y′), they cannot perform the probe operation under lambda control even though the two are probeable.
The bottom of the computing platform can be provided with a plurality of identical subregions, each subregion contains a plurality of connection sites, and the connection sites are used for connecting data roots, and the data roots are further connected with data so that one end of the data is connected at a fixed position at the bottom of the computing platform. The number of the subareas can reach 10 14, and the number of the connecting sites of each subarea can be the scale of the problem to be solved, so that the problem to be solved can be calculated in a large amount in parallel.
A computing platform embodiment may be a container made of PE or glass or the like.
The first container 13 is used to store a data root, i.e. the first reactant in the present invention, which may be referred to as a database, denoted as Z. The data root in the data root library Z is a kind of "connection" for finding a certain data and connecting it to the bottom of the fifth container 17. The number of data root categories in Z corresponds to the data categories in database X and to the types of junction sites in the sub-regions. If z i is a certain data root, x i is data corresponding to z i, and w i is a connection site corresponding to z i, then after z i enters the computing platform, w i can be accurately found and connected with the computing platform; when x i enters the computing platform, z i accurately recognizes and connects to x i.
The detector 19 only needs to detect all the data aggregates isomorphic with the preset probe operation diagram (which is constructed in advance according to the data to be processed), namely the true solution of the problem. Detection can be performed using atomic force microscopy AFM or scanning electron microscopy.
According to the data processing device provided by the embodiment of the invention, in a data processing process, any third reactant can directly react with a specific second reactant fixed by the first reactant, and a large number of third reactants can react with the second reactant in parallel, so that the data processing efficiency is improved. In addition, the second reactants are fixed in the fifth container through the first reactants, so that the second reactants with a larger physical distance cannot be connected into a polymer through the third reactants, and the situation of non-true decomposition of the second polymer can be effectively reduced. In addition, the second reactant which is not fixed in the fifth container is washed after the first reactant reacts with the second reactant, so that the second reactant which is free to move in the space of the fifth container is not available, and the obstruction encountered when the third reactant searches for the specific second reactant can be effectively reduced.
In summary, the data processing apparatus provided by the embodiment of the present invention is particularly suitable for processing problems such as SAT problems, hamilton loop problems, graph coloring, 0-1 integer programming, and other NP-hard problems convertible into graph problems, and can effectively improve the solution efficiency and calculation accuracy of NP-hard problems.
Fig. 4 is a flow chart of a data processing method according to an embodiment of the present invention, including:
S41, a processing instruction input module inputs a processing instruction to a controller;
S42, the controller sends a first instruction to the first switch according to the processing instruction;
S43, a first switch is opened according to a first instruction, so that a first reactant pre-stored in a first container enters a fifth container and is connected with the bottom fixed position of the fifth container;
S44, after the first preset time is reached, the controller sends a second instruction to the second switch and a fourth instruction to the fourth switch Guan Fasong;
S45, the second switch is opened according to a second instruction, the fourth switch is opened according to a fourth instruction, a second reactant pre-stored in the second container and a reaction medium pre-stored in the fourth container enter a fifth container, and the first reactant and the second reactant react under the action of the reaction medium to generate a first polymer;
s46, after reaching a second preset time, the controller controls the fifth container to remove unreacted first reactant and second reactant in the fifth container in a flushing mode;
s47, after reaching a third preset time, the controller sends a third instruction to the third switch and a fourth instruction to the fourth switch Guan Fasong;
S48, the third switch is opened according to a third instruction, the fourth switch is opened according to a fourth instruction, a third reactant pre-stored in the third container and a reaction medium pre-stored in the fourth container enter the fifth container, and the first polymer and the third reactant react under the action of the reaction medium to generate a second polymer;
S49, after the fourth preset time is reached, the controller controls the fifth container to remove unreacted reactants in a flushing mode;
S50, the controller sends a detection instruction to the detector;
S51, the detector detects the second polymer according to the detection instruction to obtain a detection result, and sends the detection result to the controller;
S52, the controller judges whether the second polymer is a processing result according to the detection result sent by the detector.
Since the data processing flow provided by the embodiment of the present invention has been described in detail in the above data processing apparatus, details are not repeated here.
The following is a detailed description of a specific example.
Solving a 6-order 3-color map shown in fig. 5, whose color invariant set is V "= {1,2,3}. By color invariant set is meant any coloring of the graph, the color of these vertices always being unchanged.
Based on the V "coloration, a color table is created in which the number of coloration is as small as possible, as shown in table 1: the uppermost numbers 1,2, …,6 represent the vertex labels of the graph; the column in which each vertex i (1.ltoreq.i.ltoreq.6) is located is a possible color, the marks r, g, b respectively represent red, green and blue, and the subscripts are vertex marks.
TABLE 1
| 1 | 2 | 3 | 4 | 5 | 6 |
| r1 | r4 | r5 | r6 | ||
| g2 | g5 | g6 | |||
| b3 | b4 | b6 |
Constructing a database: based on table 1, the database is made up of 6 data, denoted x 1,x2,x3,x4,x5,x6, the data cells of which mark the vertex names of the graph, the corresponding data fibers being all possible coloring of the vertex. The data fiber sets corresponding to these 9 data are then given by all the corresponding columns in Table 1, respectively, i.e
The data making method comprises the following steps: the nanoparticle is used as a data cell, and the DNA chain is used as a data fiber. According to the number p i of data fibers carried on the data, the nanoparticle is divided into p i connected regions more equally, and then as many identical data fibers, namely DNA sequences, as possible are connected to each region.
Constructing a probe library: the basic principle of probe design is that adjacent vertices have no probes of the same color. The probes were designed according to each side in fig. 5. Vertex i is denoted by x i, i=1, 2, …,6, and for side x 1x2, since both x 1 and x 2 are uniquely colored, the probe corresponding to x 1x2 is also unique, and is noted asSimilarly, the probe corresponding to side x 1x3 is unique and is/>The probe corresponding to the side x 2x3 is/>For edge x 2x4, since there are two possible stains for vertex x 4, there are two probes for x 2x4: For edge x 4x5, since there are 2 possible tints for x 4 and 2 for x 5, note that adjacent vertices are different in color, there are a total of 3 probes between them: /(I) The remainder are similar and are detailed in Table 2. The columns corresponding to x ixt are denoted as all probes in the sub-probe pool Y it, where i, t=1, 2, …,6,i +.t, thus, there are a total of 8 sub-probe pools, 18 probes.
TABLE 2
The manufacturing method of the probe comprises the following steps: based on the programmability and flexibility of DNA, DNA strands are used as the design material for the probe. Is provided with Two fibers on data x i and x t, respectively, if both fibers can be probed, their probes are denoted/>By/>And/>The complementary strand of the DNA strand consisting of each half of the DNA strand (the half not linked to the nanoparticle).
Computing platform design: the computing platform was placed in solution with a bottom provided with sub-areas of about 1014, each sub-area containing 6 connection sites, corresponding to 6 vertices of the problem to be solved, respectively, as shown in fig. 6. Since we have prepared many subregions in solution, a large number of parallel calculations can be made to solve the problem.
The data root is then connected on the computing platform for the next step of data connection. As shown in fig. 7, fig. 7 shows the computing platform after the data root is attached, and the data root is attached to the outside of the computing platform and can swing freely in solution.
The method for manufacturing the data root comprises the following steps: let z i be a data root, x i be the data corresponding to z i, w i be the ligation site corresponding to z i,Is a unique fiber DNA strand on x i, then z i is/>Is added to the DNA strand of (C). And for w i, for z i, antibodies, so that the DNA strand of z i is specifically bound to the corresponding ligation site.
The operation steps of this embodiment are given below:
step 1, 6 data cells (6 vertices in fig. 5) are prepared, and the DNA sequences corresponding to 10 data fibers are encoded and synthesized. Furthermore, DNA strands (data fibers) are embedded on the corresponding nanoparticles (i.e., data cells); and placing the manufactured data into a second container.
Step 2, synthesizing a probe library consisting of 18 probes according to the manufacturing principle of the probes in the probe library; and placing the manufactured probe into a third container.
And 3, placing the computing platform in a solution, wherein the bottom of the computing platform is provided with about 1014 subareas, and each subarea is provided with 6 connection sites, which respectively correspond to 6 vertexes of the problem to be solved.
Step 4, according to 6 kinds of data in the database, 6 kinds of data roots corresponding to the 6 kinds of data are manufactured; and carrying out antibody modification on the data root, modifying the corresponding connecting site by using an antigen, and placing the prepared data root into a first container.
Step 5, taking out a proper amount of 6 data roots from the first container, and injecting the 6 data roots into a computing platform, namely a fifth container; the data root is specifically bound to a specific attachment site by binding of antigen and antibody.
Step 6, taking out an appropriate amount of 6 kinds of data from the second container, taking out an appropriate amount of reaction medium from the fourth container, and injecting the reaction medium into a fifth container; through the specific hybridization reaction between DNA molecules, the data are connected to the connecting root under the action of the computing platform.
And 7, removing the rest substances which are not connected to the bottom of the computing platform in an ultrafiltration and centrifugation mode.
Step 8, taking out an appropriate amount of 18 probes from the third container, taking out an appropriate amount of reaction medium from the fourth container, and injecting the reaction medium into a fifth container; through the specific hybridization reaction among DNA molecules, under the action of a computing platform, various data polymers are formed.
And 9, removing the rest substances which are not connected to the bottom of the computing platform in an ultrafiltration and centrifugation mode.
Step 10, only checking all 6-order data polymers isomorphic to fig. 5 in the fifth container through detection technology, namely, true solution of the problem.
By the above reaction operation, all 3 true solutions shown in FIG. 8, i.e., 3 different 3-colors, can be found.
The apparatus embodiments described above are merely illustrative, wherein the elements illustrated as separate elements may or may not be physically separate, and the elements shown as elements may or may not be physical elements, may be located in one place, or may be distributed over a plurality of network elements. Some or all of the modules may be selected according to actual needs to achieve the purpose of the solution of this embodiment. Those of ordinary skill in the art will understand and implement the present invention without undue burden.
From the above description of the embodiments, it will be apparent to those skilled in the art that the embodiments may be implemented by means of software plus necessary general hardware platforms, or of course may be implemented by means of hardware. Based on this understanding, the foregoing technical solution may be embodied essentially or in a part contributing to the prior art in the form of a software product, which may be stored in a computer readable storage medium, such as ROM/RAM, a magnetic disk, an optical disk, etc., including several instructions for causing a computer device (which may be a personal computer, a server, or a network device, etc.) to execute the method described in the respective embodiments or some parts of the embodiments.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention.
Claims (12)
1. A data processing apparatus for fixed placement of data, comprising:
A processing instruction input module, a controller, a first container, a second container, a third container, a fourth container, a fifth container, a first switch connected to the first container and the fifth container communication path, a second switch connected to the second container and the fifth container communication path, a third switch connected to the third container and the fifth container communication path, a fourth switch connected to the fourth container and the fifth container communication path, and a detector connected between the controller and the fifth container;
The processing instruction input module is connected with the controller, and the controller is connected with the first switch, the second switch, the third switch and the fourth switch;
The controller is used for sending a first instruction to the first switch according to the processing instruction input by the processing instruction input module, so that a first reactant pre-stored in the first container enters a fifth container and is connected with the bottom fixed position of the fifth container; after reaching a first preset time, the controller sends a second instruction to the second switch, so that a second reactant pre-stored in the second container enters the fifth container, and sends a fourth instruction to the fourth switch Guan Fasong, so that a reaction medium pre-stored in the fourth container enters the fifth container, and the first reactant and the second reactant react under the action of the reaction medium to generate a first polymer; after reaching a second preset time, the controller controls the fifth container to remove unreacted first reactant and second reactant in the fifth container in a flushing mode; after reaching a third preset time, the controller sends a third instruction to the third switch, so that a third reactant pre-stored in the third container enters the fifth container, and sends a fourth instruction to the fourth switch Guan Fasong, so that a reaction medium pre-stored in the fourth container enters the fifth container, and the first polymer and the third reactant react under the action of the reaction medium to generate a second polymer; after reaching the fourth preset time, the controller controls the fifth container to remove unreacted reactants in a flushing mode, then controls the detector to detect the second polymer, and determines whether the second polymer is true solution of the problem to be solved according to the detection result.
2. The data processing device of claim 1, wherein the second reactant is made according to the data to be processed and the connection relationship between the data to be processed; the first reactant and the third reactant are reactants which are made according to the second reactant and matched with the second reactant.
3. The data processing device for data fixed placement according to claim 2, further comprising a data acquisition device and a reactant production device connected to the controller;
The data acquisition device is used for acquiring data to be processed and sending the data to be processed to the controller;
the controller is used for sending a reactant preparation instruction to the reactant preparation device according to the data to be processed and the connection relation between the data to be processed;
the reactant preparation device is used for preparing the first reactant, the second reactant and the third reactant according to the reactant preparation instruction.
4. The data processing device of claim 2, wherein the second reactant is composed of a nanoparticle and a plurality of DNA single strands attached to the nanoparticle, the same kind of DNA single strands being disposed on the same region of the nanoparticle; the first reactant and the third reactant are DNA single strands; the plurality of DNA single strands are DNA single strands having a plurality of DNA sequences.
5. The data processing device of claim 1, wherein the fifth container bottom is provided with a plurality of identical sub-areas, each sub-area containing a plurality of attachment sites for attaching a first reactant into the fifth container to be fixedly placed, the first reactant matching the attachment sites.
6. The data processing device of claim 5, wherein the first reactant is attached to the bottom of the fifth container in a manner that is specifically binding, wherein the first reactant is modified with an antibody, wherein the attachment site is modified with an antigen, and wherein the specific binding is achieved by antigen-antibody binding.
7. The data processing device of claim 1, wherein the reaction medium pre-stored in the fourth container is a polymerase.
8. The data processing device of claim 1, wherein the flushing mode is an ultrafiltration centrifugation mode.
9. The data processing device of claim 1, wherein the fifth container is a PE container or a glass container; the detector is an atomic force microscope AFM or a scanning electron microscope.
10. A data processing method based on the data processing apparatus of any one of claims 1 to 9, characterized by comprising:
The processing instruction input module inputs a processing instruction to the controller;
The controller sends a first instruction to the first switch according to the processing instruction, so that a first reactant pre-stored in the first container enters a fifth container and is connected with the fixed position of the bottom of the fifth container; after reaching a first preset time, the controller sends a second instruction to the second switch, so that a second reactant pre-stored in the second container enters the fifth container, and sends a fourth instruction to the fourth switch Guan Fasong, so that a reaction medium pre-stored in the fourth container enters the fifth container, and the first reactant and the second reactant react under the action of the reaction medium to generate a first polymer; after reaching a second preset time, the controller controls the fifth container to remove unreacted first reactant and second reactant in the fifth container in a flushing mode; after reaching a third preset time, the controller sends a third instruction to the third switch, so that a third reactant pre-stored in the third container enters the fifth container, and sends a fourth instruction to the fourth switch Guan Fasong, so that a reaction medium pre-stored in the fourth container enters the fifth container, and the first polymer and the third reactant react under the action of the reaction medium to generate a second polymer; after reaching the fourth preset time, the controller controls the fifth container to remove unreacted reactants in a flushing mode, then controls the detector to detect the second polymer, and determines whether the second polymer is true solution of the problem to be solved according to the detection result.
11. The data processing method according to claim 10, wherein the second reactant is prepared according to data to be processed and a connection relationship between the data to be processed;
when the graph problem is processed, the controller takes each data in the data to be processed as a vertex, and takes the connection relation between the data to be processed as an edge.
12. The data processing method of claim 11, wherein the fifth container bottom is provided with a plurality of identical sub-areas, each sub-area containing a plurality of connection sites for connecting the first reactant entering the fifth container for a fixed placement thereof, each sub-area having a number of connection sites equal to the order of the graph.
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