CN112618556A - Formula of massage cream for treating depression and application of massage cream - Google Patents
Formula of massage cream for treating depression and application of massage cream Download PDFInfo
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Abstract
The invention relates to a formula of a plaster for treating depression and application thereof, wherein the formula comprises the following raw material medicines in parts by weight: 300 parts of methyl salicylate, 16 parts of dextro-limonene and 1684 parts of yellow vaseline. The preparation method comprises the following steps: firstly, taking the raw materials according to the weight parts, then stirring yellow vaseline and heating in a water bath until the yellow vaseline is molten, then sequentially adding methyl salicylate and dextrolimonene into the yellow vaseline, and continuously stirring until the mixture is condensed into a cream. When in use, the ointment is used for treating according to the ointment-massage therapy. The experimental result shows that the improvement degree of the prescription in daily life ability and depression state is more obviously superior to that of a control group which adopts the traditional Chinese ilex ointment as the ointment. The invention generates clinical curative effect by double input of touch and smell and psychological interaction with depression patients, has multiple effects in aspects of relieving emotion, easing pain, improving sleep, cognition and mental state, and has good application prospect.
Description
Technical Field
The invention relates to the technical field of medicines, in particular to a formula of a massage cream for treating depression and application thereof.
Background
Depression is the most common depressive disorder, with a major clinical feature of marked and persistent mood depression, the major type of mood disorder. The low mood is not matched with the situation in clinic, the depression of the mood can be from sultriness to sadness, and the self-declining depression and even the pessimism are taken away, and suicide attempts or behaviors can be caused; even the occurrence of stupor; in some cases, there is significant anxiety and motor agitation; in severe cases, psychotic symptoms such as hallucinations and delusions may occur. Each episode lasts at least 2 weeks, more than long, or even years, and most cases have a tendency to have recurrent episodes, most of which can be alleviated, and some of which can have residual symptoms or become chronic.
The etiology of depression is not well understood, but it is believed that many factors in biological, psychological and social environments are involved in the pathogenesis of depression. Biological factors mainly relate to the aspects of heredity, neurobiochemistry, neuroendocrine, nerve regeneration and the like; psychological predisposition closely associated with depression is a pre-pathological trait, such as depressive temperament. The exposure to stressful life events in adulthood is an important trigger for the occurrence of clinically significant depressive episodes. However, these factors do not work alone, emphasizing the interaction between genetics and the environment or stressors, and the point at which such interactions occur, has a significant impact on the development of depression.
Depression can be manifested as a single or repeated multiple depressive episodes, the clinical manifestations of which include: (1) a lowered mood; (2) retardation of thought; (3) hypovolemia; (4) impairment of cognitive function; (5) somatic symptoms: it is mainly manifested by sleep disorder, asthenia, anorexia, weight loss, constipation, pain in any part of the body, hyposexuality, sexual impotence, amenorrhea, etc.
In the prior art, a plurality of medicines and methods for treating depression exist, but certain defects exist, aiming at the defects of the prior art, the patent provides a novel melancholy treating plaster composition, and reports on the melancholy treating plaster composition and the application thereof are not found.
Disclosure of Invention
The invention aims to provide a formula of a massage cream for treating depression and application thereof, aiming at the defects of the prior art.
In order to achieve the purpose, the invention adopts the technical scheme that:
in a first aspect, the invention provides a formula of a Mogao for treating depression, which comprises the following raw material medicines in parts by weight: 300 parts of methyl salicylate, 16 parts of dextro-limonene and 1684 parts of yellow vaseline.
Preferably, the formula is prepared into the molo ointment according to an ointment preparation method.
In a second aspect, the invention provides the use of a formulation as described above in the manufacture of a medicament for the treatment of depression.
Further, the invention provides the use of a formulation as described above for the preparation of a medicament for mood relief and/or analgesia and/or sleep improvement and/or cognitive and mental state improvement.
In a third aspect, the invention provides depression treating massage cream which is prepared from the formula.
Preferably, the preparation method of the molo paste comprises the following steps:
(1) respectively taking the raw materials according to the weight part ratio, stirring yellow vaseline and heating in a water bath until the yellow vaseline is molten;
(2) sequentially adding methyl salicylate and dextro-limonene into yellow vaseline;
(3) stirring until condensed to obtain a paste.
Further, the application method of the cream is cream friction therapy, and the cream friction therapy comprises the following steps:
(1) positioning governor meridian points of the patient: rubbing cream is smeared on Baihui, Dazhui, Mingmen and Changqiang acupoints;
(2) applying to the acupoints with thumb and finger massage for 2min, and performing massage with index, middle and three fingers for 10min from vertebra to Daqiang connection line; finally, the plaster rubbing method is applied from the big spine to the long and strong spine, and the operation time is 30 s;
(3) after each operation is finished, a "+" character is drawn at the operation point to be used as a body surface positioning mark for the next operation.
Preferably, the pressure of each manipulation is 0.5kg, and the frequency is 120 times/min.
Preferably, the step is performed on a cream-mole regimen of 1 time/day, 5 times/week for 2 weeks.
The invention has the advantages that:
the raw materials are preferably selected and the weight parts of the raw materials are preferably matched, and the obtained formula of the plaster is combined with a plaster-massaging therapy, so that the plaster has good curative effects on treating depression, relieving emotion, easing pain, improving sleep and cognitive and mental states. The ointment is used for generating clinical curative effect by double input of touch and smell and psychological interaction with a depressed patient, in the process of intervening the depressed patient, the dextro-limonene in the formula of the ointment is more beneficial to improvement of depression treatment effect than menthol in the original Chinese holly leaf ointment, and the patient has better experience on the sense of smell and external touch of the depression treatment ointment and has good application prospect.
Drawings
FIG. 1 is a photograph of Mogao.
Fig. 2 is a scenario when a patient is being treated.
Detailed Description
The invention will be further illustrated with reference to specific embodiments. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Furthermore, it should be understood that various changes and modifications can be made by those skilled in the art after reading the disclosure of the present invention, and equivalents fall within the scope of the appended claims.
Example 1 cream formulation
300 parts of methyl salicylate, 16 parts of dextro-limonene and 1684 parts of yellow vaseline.
EXAMPLE 2 preparation of Mogao
Taking the raw materials according to the parts by weight in the embodiment 1, manually stirring yellow vaseline, heating in a water bath until the yellow vaseline is melted, sequentially adding methyl salicylate and dextrolimonene into the yellow vaseline, and continuously stirring until the mixture is condensed into a paste.
EXAMPLE 3 clinical trials
1 data of
40 depression patients of Yueyang Chinese and western medicine combined Hospital rehabilitation department and tuina department of Shanghai medicine university in 1 month in 2020 to 8 months in 2020 are selected, and the random remainder method is divided into an observation group and a control group, wherein each group comprises 20 cases. The control group adopts the traditional Chinese holly leaf ointment as the ointment for carrying out the ointment-massage treatment, and the observation group adopts the depression treating ointment as the ointment for carrying out the ointment-massage treatment. Group 20 were observed, 12 men and 8 women; the control group comprises 20 cases, 9 men and 11 women. All subjects were between 20-70 years of age. The general data of the two groups of patients include sex, age, disease course, education period, and the difference is not statistically significant (P >0.05), and is comparable. (details are shown in Table 1)
Table 1: comparison of baseline data between two groups of patients
2 group selection
All patients accord with the diagnosis standard of depression in the classification scheme and diagnosis standard 3 rd edition of Chinese mental disorder, voluntarily enter the group, and sign an informed consent, and the 17 items before Hamilton Depression Scale (HAMD) are more than or equal to 17 points; patients with unstable vital signs and severe suicidal tendencies were excluded.
3 method
3.1 methods of treatment
The control group adopts the traditional Chinese holly leaf ointment as the ointment for carrying out the ointment-massage treatment, and the observation group adopts the depression treating ointment as the ointment for carrying out the ointment-massage treatment.
Specifically, the method comprises the following steps:
observation group
The manual intervention is performed by using the stasis-treating plaster, and because the governor vessel runs along the meridians and kidneys, enters the brain, passes through the heart and the disorder of the qi of the governor vessel can directly cause emotional diseases, the governor vessel called yang sea is the conventional choice of plaster-massage for treating depression. Positioning governor meridian points of the patient: applying 1-3g of depression treating paste to Baihui, Dazhui, Mingmen and Changqiang acupoints respectively, applying to the acupoints for 2min by thumb-finger massage, and performing M ó on the acupoints with the index, middle and three fingers for 10 min; finally, the plaster-rubbing method is applied from Dazhui to Changqiang, the operation time is 30s, the pressure of the manipulations is controlled to 0.5kg, and the frequency is 120 times/min. After each operation is finished, a "+" character is drawn at the operation point to be used as a body surface positioning mark for the next operation. The above operations are performed 1 time/day, 5 times/week, and for 2 weeks. Formula of the stasis-treating ointment: 300g of methyl salicylate, C16g lemon and 1684g of yellow vaseline.
Control group
The treatment method is consistent with that of the observation group, and the traditional Chinese ilex ointment is adopted as the plaster for massage. The formula of the Chinese ilex paste comprises the following components: 300g of methyl salicylate, 16g of menthol and 1684g of yellow vaseline.
3.2 quality control
The treatment part of the study is completed by the same physician. In order to control the quality of the manipulations, the physician was trained on a TN-II type manipulation measuring instrument for one week before the start of the study, with a force set at 0.5kg and a frequency of 100. + -. 10 times/min. Meanwhile, the manipulation operator, the scale evaluator and the statistical data person are different researchers which are independent of each other, and blindness is applied to the evaluation doctor and the statistical person.
3.3 therapeutic efficacy criteria
The clinical efficacy of the two groups was evaluated by Hamilton (HAMD-24 edition) reduction ratio before and after treatment. After 2 weeks of treatment, the HAMD reduction rate is more than or equal to 75 percent, the HAMD reduction rate is cured, 50 to 75 percent of HAMD reduction rate is significant, 25 to 50 percent of HAMD reduction rate is effective, less than 25 percent of HAMD reduction rate is ineffective, and the total effective rate is (cured, significant and effective) cases/total cases multiplied by 100 percent.
3.4 statistical treatment
Statistical analysis is carried out by adopting SPSS22.0, and counting data comparison is carried out by adopting X2Checking and measuring data
Indicates that the intra-group comparison uses paired t-test, and the inter-group comparison uses independent sample t-test, denoted by P<0.05 is statistically different.
4 results
4.1 Total efficacy analysis
According to the HAMD score difference value after 2 weeks of treatment, the number of cured people in the observation group is 3, the effect is obvious 7, the effect is 11 and the effect is not 3, the total effective rate is 90%, and the total effective rate is obviously superior to that in the control group. (details are shown in Table 2)
Table 2: comparative examples of overall therapeutic effects of both groups (%)
4.2 HAMD score comparison
The HAMD scores were statistically different in both pre-and post-treatment groups (P <0.05) and post-treatment HAMD scores in the observation and control groups. (see Table 3 for details)
Table 3: the two sets of HAMD scores were compared (score,
)
4.3 adverse event analysis
Adverse reactions after treatment of the two groups include headache, dry mouth, excitement and insomnia. The incidence rate of adverse reactions of the observed group and the control group is 15 percent and 25 percent. All patients did not shed during the intervention (see table 4 for details).
Table 4: adverse reaction of two groups of patients
Discussion of 5
The global incidence of depression is about 11%, which has been second only to cardiovascular diseases. The onset of depression is closely related to psychology, genetics, physiological changes of human body, neuroendocrine and the like, and the physical and mental health and the life quality of patients are seriously influenced. Conventional antidepressant drug therapy has certain limitations, and guidelines recommend the use of comprehensive therapies such as traditional Chinese medicine, music, meditation, psychology and the like to intervene in depression.
The understanding of the traditional Chinese medicine on the depression syndrome is from the theory of five depression of internal channel to the theory of six depression of Danxi heart method and then to the academic idea of clearing and clearing the emotion causing depression, and the modern traditional Chinese medicine considers that the body needs to be more emotional when treating depression, is in accordance with the special way of mainstream medicine, and accords with the treatment view of depression under the background of a biological-psychological-social medical treatment mode. TCM tuina, guided by the theory of TCM, has a significant effect on treating depression, just as Sheng Ji Zong Lu: Most of the massage method, every Kaida suppression for the meaning. Kaida is the source of the obstruction, and the restrained one has a final destination It is indicated that tuina has the actions of dispersing qi, tonifying deficiency and reducing excess from ancient times. Advocate tuina is the method of regulating governor meridian to be the first one, and Mao Mo is the important component of traditional tuina for external treatment, and takes the concept of regulating governor meridian to be the first one, and applies manipulations in combination with stasis-treating ointment to intervene in various aspects of qi, blood, meridians and viscera of human body, so as to achieve the effect of relieving depression. Meanwhile, aiming at the problems that the qi and blood circulation of the governor vessel is difficult to be smooth, the healthy qi is insufficient, the governing is not right, the ointment is used for regulating the channels and collaterals, regulating the qi and the blood and exciting the yang qi, has the treatment advantages of correcting the body resistance and clearing the source, and has good treatment compliance for patients.
The study adopts the characteristic ointment of the massage external treatment method to intervene depression, and carries out clinical research intervention under the coordination of the 'depression treating ointment', and the result indicates that the organic combination of the massage method and the 'depression treating ointment' has obviously better depression score improvement degree than the traditional Chinese holly leaf ointment serving as a control group of the ointment, and the analysis is carried out based on the curative effect: the touch feeling exogenous sensation caused by the cooperation of the depression treatment ointment and the plaster is bound to cause the self psychological endogenous sensation regulation, the specific orange fragrance in the depression treatment ointment has multiple effects of relieving mood, easing pain, improving sleep, cognition and mental state similar to those of the foreign aromatherapy and the essential oil therapy, the plaster generates clinical curative effect through double input of touch and smell and psychological interaction with depression patients, in the treatment process, the dextro-limonene in the formula of the plaster is more beneficial to improvement of depression treatment effect than menthol in the original Chinese holly leaf ointment, the patients have better experience on smell and external touch feeling of the depression treatment ointment, and the key element of applying the depression treatment ointment to perform plaster intervention depression treatment effect possibly is provided.
Example 4 control test
1 data of
20 depression patients of Yueyang Chinese and western medicine combination hospital rehabilitation department and tuina department of Shanghai medicine university in 1 month in 2020 to 8 months in 2020 are selected and randomly divided into an observation group and a control group, 10 cases each. The general data of the two groups of patients include sex, age, disease course, disease nature, disease position, education age, and the difference is not statistically significant (P >0.05), and has comparability.
2 group selection
The same as in example 3.
3 methods of treatment
The formula of the control group is as follows: 350 parts of methyl salicylate, 30 parts of dextrolimonene and 1620 parts of yellow vaseline, and the obtained mixture is prepared into a plaster for treating depression.
Both groups were used as in example 3.
The quality control, therapeutic effect judgment criteria and statistical treatment methods were the same as in example 3.
4 results
4.1 Total efficacy analysis
According to the HAMD score difference value after 2 weeks of treatment, the number of cured people in the observation group is 0, the number of cured people is 7, the number of cured people is 11, the number of cured people is 3, the total effective rate is 85.71%, and the total effective rate is obviously superior to that in the control group. (see Table 5 for details)
Table 5: comparative examples of overall therapeutic effects of both groups (%)
4.2 adverse event analysis
Adverse reactions after treatment of the two groups include headache, dry mouth, excitement and insomnia. The incidence rate of adverse reactions of the observed group and the control group is 10.00 percent and 30.00 percent. All patients did not shed during the intervention (see table 6 for details).
Table 6: adverse reaction of two groups of patients
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and additions can be made without departing from the principle of the present invention, and these should also be considered as the protection scope of the present invention.
Claims (9)
1. The formula of the massage cream for treating depression is characterized by comprising the following raw material medicines in parts by weight: 300 parts of methyl salicylate, 16 parts of dextro-limonene and 1684 parts of yellow vaseline.
2. The formulation of claim 1, wherein the formulation is formulated as a friction cream according to a cream formulation method.
3. Use of the formulation of claim 1 in the preparation of a medicament for treating depression.
4. Use of a formulation according to claim 1 for the preparation of a medicament for mood relief and/or pain relief and/or sleep improvement and/or cognitive and mental state improvement.
5. The depression-treating plaster is characterized by being prepared from the formula of claim 1.
6. The plaster according to claim 6, wherein the preparation method comprises the following steps:
(1) respectively taking the raw materials according to the weight part ratio, stirring yellow vaseline and heating in a water bath until the yellow vaseline is molten;
(2) sequentially adding methyl salicylate and dextro-limonene into yellow vaseline;
(3) stirring until condensed to obtain a paste.
7. The plaster of claim 6, wherein the application method of the plaster is a plaster-on-the-mole therapy, and the plaster-on-the-mole therapy comprises the following steps:
(1) positioning governor meridian points of the patient: rubbing cream is smeared on Baihui, Dazhui, Mingmen and Changqiang acupoints;
(2) applying to the acupoints with thumb and finger massage for 2min, and performing massage with index, middle and three fingers for 10min from vertebra to Daqiang connection line; finally, the plaster rubbing method is applied from the big spine to the long and strong spine, and the operation time is 30 s;
(3) after each operation is finished, a "+" character is drawn at the operation point to be used as a body surface positioning mark for the next operation.
8. The plaster of claim 8, wherein the manipulation pressure is 0.5kg and the frequency is 120 times/min.
9. The plaster of claim 8, wherein the step of the cream regimen is 1 time/day, 5 times/week for 2 weeks.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115282183A (en) * | 2022-09-06 | 2022-11-04 | 上海市静安区江宁路街道社区卫生服务中心 | Traditional Chinese medicine composition for treating chronic fatigue syndrome and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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