CN112618510A - Hollow capsule and preparation method thereof - Google Patents

Hollow capsule and preparation method thereof Download PDF

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Publication number
CN112618510A
CN112618510A CN202011590343.XA CN202011590343A CN112618510A CN 112618510 A CN112618510 A CN 112618510A CN 202011590343 A CN202011590343 A CN 202011590343A CN 112618510 A CN112618510 A CN 112618510A
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CN
China
Prior art keywords
glue
capsule
cap body
temperature
drying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202011590343.XA
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Chinese (zh)
Inventor
潘晓元
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xinchang Tianmu Chemical Co ltd
Original Assignee
Xinchang Tianmu Chemical Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xinchang Tianmu Chemical Co ltd filed Critical Xinchang Tianmu Chemical Co ltd
Priority to CN202011590343.XA priority Critical patent/CN112618510A/en
Publication of CN112618510A publication Critical patent/CN112618510A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/077Manufacturing capsule shells

Abstract

The invention relates to the technical field of hollow capsules, and discloses a hollow capsule and a preparation method thereof, which solve the problems that the conventional capsule has poor compression resistance, poor connection firmness and easy falling, and poor connection tightness easily causes medicament failure; the convex strips, the clamping grooves and the second locking notches are arranged on the cap body, and the long grooves, the protrusions and the first locking notch structures are arranged on the bag body, so that the connection firmness is better, and the falling-off phenomenon is effectively avoided; through the sealing ring and the sawtooth groove that set up in the internal portion of cap and with the utricule on the sawtooth structure that sets up, increase the leakproofness after the registrate, effectual medicament of avoiding is lost efficacy.

Description

Hollow capsule and preparation method thereof
Technical Field
The invention belongs to the technical field of hollow capsules, and particularly relates to a hollow capsule and a preparation method thereof.
Background
The hollow capsule is composed of a cap and a body which are refined by medicinal gelatin and auxiliary materials, and is mainly used for containing solid medicines.
The existing hollow capsule is easy to extrude to form a recess or flatten when being conveyed, the compression resistance is poor, and when the existing capsule is sleeved, the cap body is generally sleeved outside the capsule body directly, the firmness of the sleeved connection structure is poor, and the cap body is easy to fall off.
Disclosure of Invention
Aiming at the situation, in order to overcome the defects of the prior art, the invention provides the hollow capsule, which effectively solves the problems that the existing capsule has poor compression resistance, poor connection firmness and easy falling off, and the poor connection tightness easily causes the failure of the medicament.
In order to achieve the purpose, the invention provides the following technical scheme: the utility model provides a hollow capsule, including utricule and the cap body, utricule internal connection has first enhancement strip, utricule one end is connected with the sawtooth, long recess has been seted up for utricule outside circumference to sawtooth one side, the inside equidistance of long recess is connected with the arch, first fore shaft has been seted up for the utricule outside to long recess one side, cap body internal connection has the second enhancement strip, second enhancement strip one side is connected with the sealing ring, the serration groove has been seted up to sealing ring one end, sealing ring one side has the sand grip for cap body inner wall circumference connection, the draw-in groove has been seted up to sand grip.
According to the technical scheme, the first reinforcing strips and the second reinforcing strips are wavy.
According to the technical scheme, the number of the sawteeth is the same as that of the sawtooth grooves, and the angles of the tips of the sawteeth and the bottoms of the sawtooth grooves are both 60 degrees.
According to the technical scheme, the outer part of the upper end of each convex strip is provided with the rounding angle.
According to the technical scheme, the two sides of the inner wall of the upper part of the long groove are provided with the guide arc edges.
According to the technical scheme, the sawteeth and the bag body are integrally formed, and the sealing ring and the cap body are integrally formed.
According to the technical scheme, sugar-coated layers are arranged outside the capsule body and the cap body.
A preparation method of the hollow capsule comprises the following steps: step one, weighing and proportioning; step two, sol is carried out; dipping glue, molding and drying; step four, cutting; step five, sheathing; step six, packaging and warehousing;
in the first step, the amount of a feeding prescription is calculated according to a production instruction formula, the amount of required raw material is weighed, during weighing, whether the name of a material product conforms to the prescription is checked, whether a metering device is in a verification period is checked, and the weighing is carried out after zero setting;
in the second step, the raw materials are added into purified water through a sol pot device, stirred uniformly, heated to 90 ℃, and treated at constant temperature for 30 minutes to be dissolved into uniform sol liquid; the temperature of the glue solution is reduced to 60 ℃ for 40 minutes, and foams on the liquid surface are removed;
in the third step, in the automatic drying equipment, after the mould is subjected to hot drying treatment, the temperature of the drying channel is reduced to the normal blank making temperature of 29-30 ℃, the temperature of the glue dipping tank is set, glue in the heat-preserving container is placed into the glue dipping tank, and the temperature of the glue dipping tank A is controlled: 56-58 ℃, temperature of the glue tank B: 46-48 ℃, after the temperature of the dipping glue groove is constant, controlling the temperature of the drying line: the production line automatically dips glue, firstly, two to three rows of moulds are dipped with glue solution, technicians visually check the thickness of a wet glue skin, determine that the wet glue skin can enter a drying tunnel for drying and demoulding, then, the thickness measurement of blanks of a dried capsule body and a dried cap body is compared with an internal control standard, the concentration of the glue solution and production line parameters are adjusted to be normal according to deviation conditions, and the production line continuously dips the glue to prepare blanks;
in the fourth step, the demolded capsule is cut into a specified length by a capsule cutting machine;
in the fifth step, the cap body and the capsule body are sleeved through the capsule sleeving machine;
and in the sixth step, the sleeved capsule is placed in a closed container, stored in a cool and dry place and placed in a storehouse.
According to the technical scheme, in the first step, two persons are matched together when weighing ingredients, and 1 person weighs 1 person for checking.
According to the technical scheme, in the third step, after the blank is normal, a blank manufacturing technician checks the thickness once every 30-60 minutes, and timely adjusts the thickness to prevent the thickness of the blank from deviating from the standard regulation.
Compared with the prior art, the invention has the beneficial effects that:
(1) according to the invention, the first reinforcing strip and the second reinforcing strip which are arranged in the capsule body and the cap body are both in a wavy shape, so that after the cap body and the capsule body are sleeved, the overall structural strength of the capsule is enhanced, the shell strength of the capsule is improved, and the capsule can be effectively prevented from deforming;
(2) the convex strip, the clamping groove and the second locking notch which are arranged on the cap body, and the long groove, the protrusion and the first locking notch which are arranged on the bag body are arranged, so that when the cap body is sleeved, the convex strip and the long groove are clamped, the protrusion is clamped with the clamping groove, and the first locking notch and the second locking notch are clamped, and the cap body and the bag body can be positioned more accurately, are connected more conveniently, have better connection firmness and effectively avoid the falling-off phenomenon;
(3) the sealing ring and the sawtooth groove which are arranged in the cap body and the sawtooth structure which is arranged on the bag body are matched, and the sawtooth groove are matched in a mutual meshing mode, so that the sealing performance after the matching is improved, and the drug failure is effectively avoided.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention.
In the drawings:
FIG. 1 is a schematic structural view of the present invention;
fig. 2 is a schematic view of the structure of the capsule of the present invention;
FIG. 3 is a schematic structural view of the cap of the present invention;
FIG. 4 is an enlarged schematic view of A of FIG. 2 according to the present invention;
FIG. 5 is an enlarged view of B of FIG. 3 according to the present invention;
FIG. 6 is a flow chart of the preparation of the present invention;
in the figure: 1. a capsule body; 2. a first reinforcing strip; 3. saw teeth; 4. a long groove; 5. a protrusion; 6. a first locking notch; 7. a cap body; 8. a second reinforcing strip; 9. a seal ring; 10. a sawtooth groove; 11. a convex strip; 12. a card slot; 13. a second locking notch; 14. rounding off; 15. and guiding the arc edge.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments; all other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the first embodiment, as shown in fig. 1, 2, 3, 4, 5 and 6, the present invention comprises a bag body 1 and a cap body 7, wherein a first reinforcing strip 2 is connected inside the bag body 1 to enhance the structural strength of the bag body 1, a sawtooth 3 is connected to one end of the bag body 1, a long groove 4 is formed in one side of the sawtooth 3 relative to the outer circumference of the bag body 1, protrusions 5 are equidistantly connected inside the long groove 4, a first locking opening 6 is formed in one side of the long groove 4 relative to the outer circumference of the bag body 1, a second reinforcing strip 8 is connected inside the cap body 7 to enhance the structural strength of the cap body 7, a sealing ring 9 is connected to one side of the second reinforcing strip 8, a sawtooth groove 10 is formed in one end of the sealing ring 9, the sawtooth groove 10 and the sawtooth 3 are matched with each other to increase the sealing performance after being nested, a raised strip 11 is circumferentially connected to one side of the, draw-in groove 12 has been seted up to sand grip 11 one end equidistance, and draw-in groove 12 and protruding 5 cooperations further improve the registrate fastness, and sand grip 11 one side has been seted up second fore shaft 13 for the 7 one end of the cap body, and second fore shaft 13 and first fore shaft 6 mutually support, cup joint the cap body 7 and utricule 1.
A preparation method of the hollow capsule comprises the following steps: step one, weighing and proportioning; step two, sol is carried out; dipping glue, molding and drying; step four, cutting; step five, sheathing; step six, packaging and warehousing;
in the first step, the amount of a feeding prescription is calculated according to a production instruction formula, the amount of required raw material is weighed, during weighing, whether the name of a material product conforms to the prescription is checked, whether a metering device is in a verification period is checked, and the weighing is carried out after zero setting;
in the second step, the raw materials are added into purified water through a sol pot device, stirred uniformly, heated to 90 ℃, and treated at constant temperature for 30 minutes to be dissolved into uniform sol liquid; the temperature of the glue solution is reduced to 60 ℃ for 40 minutes, and foams on the liquid surface are removed;
in the third step, in the automatic drying equipment, after the mould is subjected to hot drying treatment, the temperature of the drying channel is reduced to the normal blank making temperature of 29-30 ℃, the temperature of the glue dipping tank is set, glue in the heat-preserving container is placed into the glue dipping tank, and the temperature of the glue dipping tank A is controlled: 56-58 ℃, temperature of the glue tank B: 46-48 ℃, after the temperature of the dipping glue groove is constant, controlling the temperature of the drying line: the production line automatically dips glue, firstly, two to three rows of moulds are dipped with glue solution, technicians visually check the thickness of a wet glue skin, determine that the wet glue skin can enter a drying tunnel for drying and demoulding, then, the thickness measurement of blanks of the dried capsule body 1 and the dried cap body 7 is compared with an internal control standard, the concentration of the glue solution and production line parameters are adjusted to be normal according to deviation conditions, and the production line continuously dips the glue to prepare blanks;
in the fourth step, the demolded capsule is cut into a specified length by a capsule cutting machine;
in the fifth step, the cap body 7 and the capsule body 1 are sleeved through the capsule sleeving machine;
and in the sixth step, the sleeved capsule is placed in a closed container, stored in a cool and dry place and placed in a storehouse.
According to above-mentioned technical scheme, first enhancement strip 2 and second are the wave, are convenient for strengthen internal structure intensity.
According to the technical scheme, the number of the sawteeth 3 is the same as that of the sawtooth grooves 10, the angle of the tips of the sawteeth 3 is 60 degrees relative to the angle of the bottoms of the sawtooth grooves 10, and the sawteeth 3 and the sawtooth grooves 10 are convenient to mutually match, so that the sealing effect is better.
According to the technical scheme, the outer part of the upper end of the convex strip 11 is provided with the fillet 14, so that when the cap body 7 is sleeved, the friction is reduced when the convex strip 11 is connected with the long groove 4 in a clamping manner.
According to the technical scheme, the two sides of the inner wall of the upper part of the long groove 4 are provided with the guide arc edges 15, so that the guide effect is achieved when the convex strips 11 are clamped conveniently.
According to the technical scheme, the sawteeth 3 and the capsule body 1 are integrally formed, and the sealing ring 9 and the cap body 7 are integrally formed, so that the capsule is tightly connected.
According to the technical scheme, in the first step, two persons are matched together when weighing ingredients, and 1 person weighs 1 person for checking.
According to the technical scheme, in the third step, after the blank is normal, a blank manufacturing technician checks the thickness once every 30-60 minutes, and timely adjusts the thickness to prevent the thickness of the blank from deviating from the standard regulation.
According to the technical scheme, the sugar-coated layers are arranged outside the capsule body 1 and the cap body 7, so that the capsule is prevented from being bitter and uncomfortable when being eaten.
The working principle is as follows: when using, cap body 7 and utricule 1 are when the registrates, the sand grip 11 of the 7 inner walls of the cap body and the 4 joints of long recess of 1 upper portion outer end of utricule, after sand grip 11 and the 4 joints of long recess, draw-in groove 12 on the sand grip 11 is located the inside 5 outsides of arch of 4 long recesses, make protruding 5 and the mutual joint of draw-in groove 12, thereby improve capsule structural strength, after cap body 7 registrates with utricule 1, sawtooth groove 10 on the sealing ring 9 is located sawtooth 3 outsides on utricule 1, sawtooth 3 and the mutual interlock of sawtooth groove 10, thereby increase capsule leakproofness, in addition, through the setting of first enhancement strip 2 and second enhancement strip 8, make capsule structural strength increase.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (10)

1. An empty capsule, includes utricule (1) and cap body (7), its characterized in that: utricule (1) internal connection has first enhancement strip (2), utricule (1) one end is connected with sawtooth (3), long recess (4) have been seted up for utricule (1) outside circumference in sawtooth (3) one side, long recess (4) inside equidistance is connected with arch (5), first fore shaft (6) have been seted up for utricule (1) outside in long recess (4) one side, cap body (7) internal connection has second enhancement strip (8), second enhancement strip (8) one side is connected with sealing ring (9), serration groove (10) have been seted up to sealing ring (9) one end, sealing ring (9) one side has sand grip (11) for cap body (7) inner wall circumference, draw-in groove (12) have been seted up to sand grip (11) one end equidistance, second fore shaft (13) have been seted up for cap body (7.
2. An empty capsule according to claim 1, wherein: the first reinforcing strip (2) and the second reinforcing strip (8) are both wavy.
3. An empty capsule according to claim 1, wherein: the number of the saw teeth (3) is the same as that of the saw tooth grooves (10), and the tip angles of the saw teeth (3) and the bottom angles of the saw tooth grooves (10) are both 60 degrees.
4. An empty capsule according to claim 1, wherein: and the outer part of the upper end of each convex strip (11) is provided with a fillet (14).
5. An empty capsule according to claim 1, wherein: and guide arc edges (15) are arranged on two sides of the inner wall of the upper part of the long groove (4).
6. An empty capsule according to claim 1, wherein: the sawtooth (3) and the capsule body (1) are integrally formed, and the sealing ring (9) and the cap body (7) are integrally formed.
7. An empty capsule according to claim 1, wherein: sugar-coating layers are arranged outside the capsule body (1) and the cap body (7).
8. A preparation method of the hollow capsule comprises the following steps: step one, weighing and proportioning; step two, sol is carried out; dipping glue, molding and drying; step four, cutting; step five, sheathing; step six, packaging and warehousing; the method is characterized in that:
in the first step, the amount of a feeding prescription is calculated according to a production instruction formula, the amount of required raw material is weighed, during weighing, whether the name of a material product conforms to the prescription is checked, whether a metering device is in a verification period is checked, and the weighing is carried out after zero setting;
in the second step, the raw materials are added into purified water through a sol pot device, stirred uniformly, heated to 90 ℃, and treated at constant temperature for 30 minutes to be dissolved into uniform sol liquid; the temperature of the glue solution is reduced to 60 ℃ for 40 minutes, and foams on the liquid surface are removed;
in the third step, in the automatic drying equipment, after the mould is subjected to hot drying treatment, the temperature of the drying channel is reduced to the normal blank making temperature of 29-30 ℃, the temperature of the glue dipping tank is set, glue in the heat-preserving container is placed into the glue dipping tank, and the temperature of the glue dipping tank A is controlled: 56-58 ℃, temperature of the glue tank B: 46-48 ℃, after the temperature of the dipping glue groove is constant, controlling the temperature of the drying line: the production line automatically dips glue, firstly, two to three rows of moulds are dipped with glue solution, technicians visually check the thickness of a wet glue skin, determine that the wet glue skin can enter a drying tunnel for drying and demoulding, then, the thickness measurement of blanks of a dried capsule body (1) and a dried cap body (7) is compared with an internal control standard, the concentration of the glue solution and production line parameters are adjusted to be normal according to deviation conditions, and the production line continuously dips the glue to prepare the blanks;
in the fourth step, the demolded capsule is cut into a specified length by a capsule cutting machine;
in the fifth step, the cap body (7) and the capsule body (1) are sleeved through a capsule sleeving machine;
and in the sixth step, the sleeved capsule is placed in a closed container, stored in a cool and dry place and placed in a storehouse.
9. A method of making an empty capsule according to claim 8, wherein: in the first step, two persons are matched together when weighing ingredients, and 1 person weighs 1 person for checking.
10. A method of making an empty capsule according to claim 8, wherein: and in the third step, after the blank is normal, the blank manufacturing technician checks the thickness once every 30-60 minutes, and timely adjusts the thickness to prevent the thickness of the blank from deviating from the standard regulation.
CN202011590343.XA 2020-12-29 2020-12-29 Hollow capsule and preparation method thereof Pending CN112618510A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202011590343.XA CN112618510A (en) 2020-12-29 2020-12-29 Hollow capsule and preparation method thereof

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Application Number Priority Date Filing Date Title
CN202011590343.XA CN112618510A (en) 2020-12-29 2020-12-29 Hollow capsule and preparation method thereof

Publications (1)

Publication Number Publication Date
CN112618510A true CN112618510A (en) 2021-04-09

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104324017A (en) * 2014-10-20 2015-02-04 浙江春宝胶囊有限公司 Hydroxypropyl methylcellulose hollow capsule and production process thereof
CN205198479U (en) * 2015-10-27 2016-05-04 浙江绿健胶囊有限公司 Practicality capsule
CN211050267U (en) * 2019-08-15 2020-07-21 新昌县联通胶囊有限公司 Plant hollow capsule
CN211272502U (en) * 2019-10-21 2020-08-18 浙江月山胶囊有限公司 Plant hollow capsule
CN211272420U (en) * 2019-08-15 2020-08-18 新昌县联通胶囊有限公司 Hollow capsule with multiple fixing rings
CN211382780U (en) * 2019-10-21 2020-09-01 浙江月山胶囊有限公司 Medicinal gelatin hollow capsule

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104324017A (en) * 2014-10-20 2015-02-04 浙江春宝胶囊有限公司 Hydroxypropyl methylcellulose hollow capsule and production process thereof
CN205198479U (en) * 2015-10-27 2016-05-04 浙江绿健胶囊有限公司 Practicality capsule
CN211050267U (en) * 2019-08-15 2020-07-21 新昌县联通胶囊有限公司 Plant hollow capsule
CN211272420U (en) * 2019-08-15 2020-08-18 新昌县联通胶囊有限公司 Hollow capsule with multiple fixing rings
CN211272502U (en) * 2019-10-21 2020-08-18 浙江月山胶囊有限公司 Plant hollow capsule
CN211382780U (en) * 2019-10-21 2020-09-01 浙江月山胶囊有限公司 Medicinal gelatin hollow capsule

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Application publication date: 20210409

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