CN112618121B - Rapamycin drug eluting carotid artery stent - Google Patents
Rapamycin drug eluting carotid artery stent Download PDFInfo
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- CN112618121B CN112618121B CN202011492327.7A CN202011492327A CN112618121B CN 112618121 B CN112618121 B CN 112618121B CN 202011492327 A CN202011492327 A CN 202011492327A CN 112618121 B CN112618121 B CN 112618121B
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- 239000003814 drug Substances 0.000 title claims abstract description 38
- 229940079593 drug Drugs 0.000 title claims abstract description 15
- 210000001715 carotid artery Anatomy 0.000 title claims abstract description 14
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title claims abstract description 13
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title claims abstract description 13
- 229960002930 sirolimus Drugs 0.000 title claims abstract description 13
- 239000002184 metal Substances 0.000 claims description 8
- 238000005452 bending Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 abstract description 30
- 210000004204 blood vessel Anatomy 0.000 abstract description 13
- 208000037803 restenosis Diseases 0.000 abstract description 10
- 230000002792 vascular Effects 0.000 abstract description 10
- 230000008093 supporting effect Effects 0.000 abstract description 9
- 238000010438 heat treatment Methods 0.000 abstract description 8
- 238000010828 elution Methods 0.000 abstract description 6
- 230000036541 health Effects 0.000 abstract description 4
- 230000002980 postoperative effect Effects 0.000 abstract description 3
- 230000008569 process Effects 0.000 description 11
- 208000029078 coronary artery disease Diseases 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 230000006835 compression Effects 0.000 description 3
- 238000007906 compression Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- KKJUPNGICOCCDW-UHFFFAOYSA-N 7-N,N-Dimethylamino-1,2,3,4,5-pentathiocyclooctane Chemical compound CN(C)C1CSSSSSC1 KKJUPNGICOCCDW-UHFFFAOYSA-N 0.000 description 1
- 206010003211 Arteriosclerosis coronary artery Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000002399 angioplasty Methods 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000007887 coronary angioplasty Methods 0.000 description 1
- 208000026758 coronary atherosclerosis Diseases 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000002966 stenotic effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/844—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents folded prior to deployment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/89—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2002/825—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents having longitudinal struts
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Prostheses (AREA)
Abstract
The invention discloses a rapamycin drug eluting carotid artery stent, which comprises a first expansion rod and an inner support rod, wherein a fixed push plate is fixedly connected to the inner support rod, a thrust wire is fixedly connected to the side surface of the fixed push plate, a sliding push plate is fixedly connected to the other end of the thrust wire, an expansion push rod is hinged to the top of the sliding push plate, the other end of the expansion push rod is hinged to the side surface of the first expansion rod, a drug carrying box is arranged on the inner support rod, a second expansion rod is hinged to one end of the first expansion rod, and an inner wall support rod is hinged to the side surface of the second expansion rod. This rapamycin medicine elution carotid artery support, through setting up of deciding push pedal, thrust silk, slip push pedal, first expansion pole, second expansion pole and inner wall bracing piece, can realize supporting effect adjustable in the in-process of using, through heating methods such as hot compress effectual blood vessel with after contracting again support, avoid postoperative vascular restenosis to cause the influence to patient's health.
Description
Technical Field
The invention relates to the technical field of medical appliances, in particular to a rapamycin drug eluting carotid artery stent.
Background
Cardiovascular disease, represented by coronary atherosclerosis, is currently the greatest threat to human health. With statistics, millions of people in China suffer from vascular stenotic diseases such as coronary heart disease every year, and currently, the common treatment methods comprise three means of oral drug treatment, surgical operation treatment and interventional treatment. The heart intervention treatment represented by percutaneous transluminal angioplasty (PTCA) and stent implantation has the advantages of small trauma, quick recovery, directional drug delivery to lesion sites, enhanced drug treatment effect and reduced systemic toxic and side effects of the drug, and becomes the most promising treatment means for the current coronary heart disease treatment.
Drug eluting stents, also known as drug-releasing stents, carry drug through polymers coated on the surface of metallic stents, and when the stent is placed in the diseased site of a vessel, the drug is controllably released from the polymer coating to the wall tissue of the vessel by elution to exert biological effects, and restenosis mechanisms after percutaneous transluminal coronary angioplasty and stent placement are mainly the healing response of local vascular sites to balloon injury, including early vascular elastic recoil, late vascular negative remodeling and neointimal hyperplasia. The stent replaces the single balloon to expand so that restenosis after coronary heart disease interventional therapy is reduced from 40 to 50 percent to 20 to 30 percent.
Most of the stents used clinically are self-expansion stents, the expansion effect of the stents is required to be calculated and designed in advance, the external influence factors received in the expansion process of the stents are more, the use complexity is greatly increased, the stents cannot be restored after being contracted under the compression of the vascular wall in the use process, the vascular restenosis can still be generated to a certain extent, and the preparation of different models according to different patients is very inconvenient.
Disclosure of Invention
(One) solving the technical problems
Aiming at the defects of the prior art, the invention provides a rapamycin drug eluting carotid artery stent which has the advantages of preventing restenosis of blood vessels and the like and solves the problems.
(II) technical scheme
In order to achieve the above purpose, the present invention provides the following technical solutions: the utility model provides a rapamycin medicine elution carotid artery support, includes first expansion bar and interior bracing piece, fixedly connected with decides the push pedal on the interior bracing piece, the side fixedly connected with thrust silk of deciding the push pedal, the other end fixedly connected with slip push pedal of thrust silk, the top of slip push pedal articulates there is the expansion push rod, the other end of expansion push rod articulates the side at first expansion bar, be equipped with on the interior bracing piece and carry the medicine box, the one end of first expansion bar articulates there is the second expansion bar, the side of second expansion bar articulates there is the inner wall bracing piece.
Preferably, every two fixed pushing plates are uniformly distributed on the inner supporting rod, and the two sides of each fixed pushing plate are provided with pressure reducing grooves.
Preferably, the thrust wires are symmetrically distributed on the corresponding side surfaces of the two fixed pushing plates, the thrust wires are arc-shaped and curved, and the thrust wires are made of memory metal.
Preferably, the bottom of the sliding push plate is provided with a chute matched with the size of the inner support rod, and the sliding push plate is connected with the outer surface of the inner support rod in a sliding way through the chute.
Preferably, the top of the sliding push plate is hinged with two expansion push rods in a spherical hinge mode, the other ends of the two expansion push rods are hinged to the side face of the first expansion rod in a spherical hinge mode, and certain included angles are formed between the two expansion push rods and the sliding push plate as well as between the two expansion push rods and the first expansion rod.
Preferably, the medicine carrying box is cylindrical, a medicine containing groove is formed in the medicine carrying box, and a plurality of capillary holes are formed in the medicine carrying box.
Preferably, a certain angle is formed between the second expansion rod and the first expansion rod, the second expansion rod forms a horn-shaped opening, and the angle between the second expansion rod and the first expansion rod is adapted according to the intravascular shape of the patient.
Preferably, the material of inner wall bracing piece is memory metal, the inner wall bracing piece is arc crooked pole, and the deformation temperature of inner wall bracing piece is unanimous with thrust silk.
Preferably, the number of the first expansion rods is a plurality of, and the plurality of the first expansion rods are distributed on the circular arcs with the same diameter.
(III) beneficial effects
Compared with the prior art, the invention provides a rapamycin drug eluting carotid artery stent, which has the following beneficial effects:
This rapamycin medicine elution carotid artery support, through deciding push pedal, thrust silk, slide the push pedal, first expansion rod, second expansion rod and inner wall bracing piece's setting, can make thrust silk and inner wall bracing piece take place deformation through heating methods such as hot compress in the in-process of using, thereby push away first expansion rod and second expansion rod and support the inside formation of blood vessel, the purpose of supporting effect adjustable has been realized, the in-process that uses this device of same model is suitable for the scope more extensive, in addition because thrust silk and inner wall bracing piece memory metal's characteristic, in the in-process of using after deformation appears because of the compression of blood vessel wall when first expansion rod and second expansion rod, can support first expansion rod and second expansion rod through heating methods such as hot compress, effectually with the blood vessel after the shrink again, avoid postoperative vascular restenosis to influence patient health.
Drawings
FIG. 1 is a schematic diagram of the overall structure of the present invention;
FIG. 2 is an enlarged schematic view of the structure of the present invention at A;
FIG. 3 is a schematic top cross-sectional view of a first expansion rod according to the present invention;
FIG. 4 is a schematic view of a partial side view of the inner support rod of the present invention;
fig. 5 is a schematic side cross-sectional view of a drug-carrying cassette of the present invention.
In the figure: 1. a first expansion rod; 2. an inner support bar; 3. a fixed push plate; 4. a thrust wire; 5. a sliding push plate; 6. expanding the push rod; 7. a drug-carrying box; 8. a second expansion rod; 9. an inner wall support rod; 10. depressurization and slotting; 11. a medicine placing groove; 12. capillary holes.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Referring to fig. 1-5, a rapamycin drug eluting carotid artery stent comprises a first expansion rod 1 and an inner support rod 2, wherein the number of the first expansion rods 1 is a plurality, the first expansion rods 1 are distributed on an arc with the same diameter, a fixed push plate 3 is fixedly connected on the inner support rod 2, every two fixed push plates 3 are uniformly distributed on the inner support rod 2, depressurization grooves 10 are respectively arranged on two sides of the fixed push plate 3, thrust wires 4 are fixedly connected on the sides of the fixed push plate 3, the thrust wires 4 are symmetrically distributed on the corresponding sides of the two fixed push plates 3, the thrust wires 4 are in an arc-shaped bending shape, the material of the thrust wires 4 is memory metal, the other end of the thrust wires 4 is fixedly connected with a sliding push plate 5, a chute matched with the size of the inner support rod 2 is arranged at the bottom of the sliding push plate 5, the sliding push plate 5 is slidingly connected with the outer surface of the inner support rod 2 through the chute, the top of the sliding push plate 5 is hinged with an expansion push rod 6, the other end of the expansion push rod 6 is hinged with the side surface of a first expansion rod 1, the top of the sliding push plate 5 is hinged with two expansion push rods 6 in a spherical hinge mode, the other ends of the two expansion push rods 6 are hinged with the side surface of the first expansion rod 1 in a spherical hinge mode, certain included angles are formed between the two expansion push rods 6 and the sliding push plate 5 as well as between the two expansion push rods 1 and the first expansion rod 1, a medicine carrying box 7 is arranged on an inner support rod 2, the medicine carrying box 7 is in a cylindrical shape, a medicine containing groove 11 is arranged in the medicine carrying box 7, a plurality of capillary holes 12 are arranged on the medicine carrying box 7, one end of the first expansion rod 1 is hinged with a second expansion rod 8, a certain angle is formed between the second expansion rod 8 and the first expansion rod 1, the second expansion rod 8 forms a horn-shaped opening, the angle between second expansion rod 8 and the first expansion rod 1 is according to the shape looks adaptation in the patient's blood vessel, the side of second expansion rod 8 articulates there is inner wall bracing piece 9, the material of inner wall bracing piece 9 is memory metal, inner wall bracing piece 9 is the arc bending pole, and the deformation temperature of inner wall bracing piece 9 is unanimous with thrust silk 4, this rapamycin medicine elution carotid artery support, through deciding push pedal 3, thrust silk 4, slide push pedal 5, first expansion rod 1, the setting of second expansion rod 8 and inner wall bracing piece 9, can make thrust silk 4 and inner wall bracing piece 9 take place the deformation through heating means such as hot compress in the in-process of using, thereby push away first expansion rod 1 and second expansion rod 8 to the inside formation support of blood vessel, the purpose that has realized supporting effect adjustable is realized, in-process same model's this device application scope is wider in addition, because thrust silk 4 and inner wall bracing piece 9 memory metal's characteristic, after the expansion mode appears in the in-process of using as first expansion rod 1 and second expansion rod 8 because of the compression of blood vessel, can be to first expansion rod 1 and second expansion rod 8, the expansion rod is effective and the restenosis of the patient after the restenosis is avoided to the patient in the use.
When the device is used, the carotid artery position needing to be supported is placed by conventional medical means such as surgery, the push wire 4 and the inner wall supporting rod 9 are deformed in an external heating mode, the push wire 4 is converted from a bending device to an extending state, the push wire 4 can generate thrust to the fixed push plate 3 and the sliding push plate 5 in the large deformation process, the fixed push plate 3 is fixed with the inner supporting rod 2, so that the sliding push plate 5 can be pushed to slide, the angle between the expansion push rod 6 and the first expansion rod 1 can be changed in the sliding process of the sliding push plate 5, the first expansion rod 1 is pushed outwards, the first expansion rod 1 is supported on the inner wall of a blood vessel, the inner wall supporting rod 9 can also push the second expansion rod 8 outwards in the deformation process, the second expansion rod 8 is supported on the inner wall of the blood vessel, when the first expansion rod 1 or the second expansion rod 8 is subjected to vascular wall pressure deformation in the use process, the expansion rod 4 and the inner wall supporting rod 9 can be pushed again in the external heating mode to expand the blood vessel, the blood vessel in the process of restenosis, blood can enter the capillary groove 11 in the flowing process, and the blood circulation resistance of the medicine can be relieved, and the medicine can flow smoothly and flow out of the side face of the groove 10 can be more easily achieved.
To sum up, this rapamycin medicine elution carotid artery support, through setting up of deciding push pedal 3, thrust silk 4, slip push pedal 5, first expansion rod 1, second expansion rod 8 and inner wall bracing piece 9, can make thrust silk 4 and inner wall bracing piece 9 take place deformation through heating methods such as hot compress in the in-process of using, thereby push away first expansion rod 1 and second expansion rod 8 and form the support to the vessel inside, the purpose of supporting effect adjustable has been realized, the in-process in use same model this device application scope is wider, in addition because thrust silk 4 and inner wall bracing piece 9 memory metal's characteristic, after deformation appears in the in-process of using when first expansion rod 1 and second expansion rod 8, can support first expansion rod 1 and second expansion rod 8 again through heating methods such as hot compress, the effectual blood vessel after will contracting, avoid postoperative vascular restenosis to cause the influence to patient health.
It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising" does not exclude the presence of other like elements in a process, method, article, or apparatus that comprises the element.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (1)
1. Rapamycin drug eluting carotid artery stent, including first expansion rod (1) and interior bracing piece (2), its characterized in that: the utility model is characterized in that a fixed push plate (3) is fixedly connected on the inner support rod (2), a thrust wire (4) is fixedly connected on the side surface of the fixed push plate (3), a sliding push plate (5) is fixedly connected on the other end of the thrust wire (4), an expansion push rod (6) is hinged at the top of the sliding push plate (5), the other end of the expansion push rod (6) is hinged on the side surface of a first expansion rod (1), a medicine carrying box (7) is arranged on the inner support rod (2), a second expansion rod (8) is hinged at one end of the first expansion rod (1), an inner wall support rod (9) is hinged at the side surface of the second expansion rod (8),
Every two fixed push plates (3) are uniformly distributed on the inner support rod (2), and depressurization grooves (10) are formed in two sides of each fixed push plate (3);
the thrust wires (4) are symmetrically distributed on the corresponding side surfaces of the two fixed push plates (3), the thrust wires (4) are in arc-shaped bending shapes, and the thrust wires (4) are made of memory metal;
The bottom of the sliding push plate (5) is provided with a chute matched with the inner support rod (2) in size, and the sliding push plate (5) is connected with the outer surface of the inner support rod (2) in a sliding way through the chute;
the top of the sliding push plate (5) is hinged with two expansion push rods (6) in a spherical hinge mode, the other ends of the two expansion push rods (6) are hinged to the side face of the first expansion rod (1) in a spherical hinge mode, and an included angle is formed between each expansion push rod (6) and the sliding push plate (5) as well as between each expansion push rod and the corresponding first expansion rod (1);
The medicine carrying box (7) is in a cylindrical shape, a medicine containing groove (11) is formed in the medicine carrying box (7), and a plurality of capillary holes (12) are formed in the medicine carrying box (7);
an angle is arranged between the second expansion rod (8) and the first expansion rod (1), the second expansion rod (8) forms a horn-shaped opening, and the angle between the second expansion rod (8) and the first expansion rod (1) is matched according to the intravascular shape of a patient;
The number of the first expansion rods (1) is a plurality of, and the first expansion rods (1) are distributed on the circular arcs with the same diameter.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011492327.7A CN112618121B (en) | 2020-12-16 | 2020-12-16 | Rapamycin drug eluting carotid artery stent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011492327.7A CN112618121B (en) | 2020-12-16 | 2020-12-16 | Rapamycin drug eluting carotid artery stent |
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| Publication Number | Publication Date |
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| CN112618121A CN112618121A (en) | 2021-04-09 |
| CN112618121B true CN112618121B (en) | 2024-05-24 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202011492327.7A Active CN112618121B (en) | 2020-12-16 | 2020-12-16 | Rapamycin drug eluting carotid artery stent |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN117752481A (en) * | 2023-12-26 | 2024-03-26 | 日照天一生物医疗科技有限公司 | Completely degradable magnesium alloy cardiovascular stent |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6013085A (en) * | 1997-11-07 | 2000-01-11 | Howard; John | Method for treating stenosis of the carotid artery |
| CN203564386U (en) * | 2013-09-12 | 2014-04-30 | 徐贵丽 | Medical orifice support capable of slowly releasing medicine |
| CN104667356A (en) * | 2013-11-27 | 2015-06-03 | 山东瑞安泰医疗技术有限公司 | In-vivo biodegradable shape memory macromolecule coronary stent system and manufacturing method thereof |
| CN210250177U (en) * | 2019-06-05 | 2020-04-07 | 郑州美港高科生物科技有限公司 | Carotid artery stent |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080200974A1 (en) * | 2007-02-15 | 2008-08-21 | Cardiac Innovations, Llc | Drug Eluting Stent System with Controlled Self Expansion |
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2020
- 2020-12-16 CN CN202011492327.7A patent/CN112618121B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6013085A (en) * | 1997-11-07 | 2000-01-11 | Howard; John | Method for treating stenosis of the carotid artery |
| CN203564386U (en) * | 2013-09-12 | 2014-04-30 | 徐贵丽 | Medical orifice support capable of slowly releasing medicine |
| CN104667356A (en) * | 2013-11-27 | 2015-06-03 | 山东瑞安泰医疗技术有限公司 | In-vivo biodegradable shape memory macromolecule coronary stent system and manufacturing method thereof |
| CN210250177U (en) * | 2019-06-05 | 2020-04-07 | 郑州美港高科生物科技有限公司 | Carotid artery stent |
Non-Patent Citations (2)
| Title |
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| 雷帕霉素洗脱支架抑制猪颈动脉成形术后近期再狭窄的实验研究;梁海兵;章希炜;董剑;邹君杰;苗毅;;南京医科大学学报(自然科学版)(第08期);990-993 * |
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