CN112617797B - Physiological signal detection method applied to magnetic resonance imaging and electronic device - Google Patents
Physiological signal detection method applied to magnetic resonance imaging and electronic device Download PDFInfo
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Abstract
The application relates to a physiological signal detection method applied to magnetic resonance imaging, a magnetic resonance imaging system, an electronic device and a storage medium, wherein the physiological signal detection method applied to magnetic resonance imaging comprises the following steps: detecting magnetic field information of the surface of the subject by a plurality of diamond NV color center sensors, wherein the diamond NV color center sensors are arranged at different positions of the surface of the subject; a physiological signal of the subject is determined based on the amount of change in the magnetic field information detected by the plurality of diamond NV color center sensors. By the method and the device, the problem of low detection accuracy of the physiological signals of the testee in the related technology is solved, and the technical effect of improving the accuracy of detecting the physiological signals of the testee is achieved.
Description
Technical Field
The present disclosure relates to the field of medical imaging technologies, and in particular, to a physiological signal detection method, a magnetic resonance imaging system, an electronic device, and a storage medium applied to magnetic resonance imaging.
Background
Medical imaging refers to techniques and procedures for non-invasively acquiring an image of internal tissue of a human body or a portion of a human body for medical or medical research. Medical imaging has been developed to date with imaging techniques other than X-ray and various imaging techniques have been developed. Common medical imaging techniques include: electron computed tomography (Computed Tomography, abbreviated as CT), magnetic resonance imaging (Magnetic Resonance Imaging, abbreviated as MRI), positron emission tomography (Positron emission tomography, abbreviated as PET), and the like.
The magnetic resonance imaging system is an imaging technology which uses signals generated by resonance of atomic nuclei in a strong magnetic field to reconstruct images, and is a nuclear physical phenomenon. The method comprises exciting nuclei containing spins other than zero in a magnetic field by using radio frequency pulses, relaxing the nuclei after the radio frequency pulses are stopped, acquiring signals by using an induction coil in the relaxation process, and reconstructing the signals according to a certain mathematical method to form a mathematical image.
Currently, medical imaging apparatuses with scanning chambers, such as an electronic computed tomography system or a magnetic resonance imaging system, are widely used in the treatment and diagnosis of clinical diseases. When the imaging part is chest and abdomen, motion artifact in the medical image can be caused by heartbeat and respiratory motion of the testee, so that the image quality is reduced; it is therefore necessary to acquire the medical image while monitoring physiological signals of the respiration and heartbeat of the subject in real time, and then reconstruct the medical image from the physiological signals to obtain a medical image corrected for motion artifacts.
In the related art, the conventional way to monitor respiration is to bind an abdominal belt with a pressure sensor on the abdomen of a subject, and acquire the variation of the pressure signal of the abdominal belt caused by respiration to monitor respiratory motion; or acquiring signal changes caused by respiration by adopting a special magnetic resonance navigation sequence in magnetic resonance imaging to monitor respiratory motion; the heartbeat electric signal monitoring is realized by attaching electrodes to the body surface of the detected person. However, such solutions are less accurate and it is difficult to achieve detection of the subject's respiratory and heartbeat signals in a harsh environment (e.g., a magnetic resonance environment).
At present, no effective solution is proposed for the problem of low detection accuracy of physiological signals of a subject in the related art.
Disclosure of Invention
The embodiment of the application provides a physiological signal detection method applied to magnetic resonance imaging, a magnetic resonance imaging system, an electronic device and a storage medium, so as to at least solve the problem of low detection accuracy of physiological signals of a subject in the related art.
In a first aspect, embodiments of the present application provide a physiological signal detection method applied to magnetic resonance imaging, including: detecting magnetic field information of the surface of the subject by a plurality of diamond NV color center sensors, wherein the diamond NV color center sensors are arranged at different positions of the surface of the subject; and determining physiological signals of the testee according to the change amount of the magnetic field information detected by the diamond NV color center sensors.
In some of these embodiments, the physiological signal comprises a respiratory signal and an electrocardiographic signal; determining a physiological signal of the subject surface based on the amount of change in magnetic field information detected by the plurality of diamond NV color center sensors comprises: determining movement information of the surface of the subject according to the change amount of the magnetic field information detected by the diamond NV color center sensors under the condition that the physiological signal comprises a respiratory signal; determining a respiration signal of the subject according to the motion information of the surface of the subject; determining potential change information of the surface of the subject according to the change amounts of the magnetic field information detected by the diamond NV color center sensors under the condition that the physiological signal comprises an electrocardiosignal; and determining electrocardiosignals of the tested person according to the potential change information of the tested person surface.
In some of these embodiments, the movement information of the subject surface includes movement information of the subject's abdominal upper epidermis and movement information of the subject's thoracic upper epidermis; determining motion information of the surface of the subject according to the change amount of the magnetic field information detected by the diamond NV color center sensors comprises: according to the magnetic field information detected by each diamond NV color center sensor, initial spatial position information of each diamond NV color center sensor is respectively determined; according to the change of the magnetic field information detected by each diamond NV color center sensor, real-time spatial position information of each diamond NV color center sensor is respectively determined; and determining the motion information of the upper epidermis of the abdomen of the subject and the motion information of the upper epidermis of the chest of the subject according to the initial spatial position information and the real-time spatial position information of each diamond NV color center sensor.
In some of these embodiments, determining the motion information of the subject's abdominal epithelium and the motion information of the subject's thoracic epithelium based on the initial spatial position information and the real-time spatial position information of each of the diamond NV color center sensors comprises: according to the initial spatial position information and the real-time spatial position information of each diamond NV color center sensor, respectively determining the initial spatial position information and the real-time spatial position information of the upper surface of the abdomen of the detected person and the initial spatial position information and the real-time spatial position information of the upper surface of the chest of the detected person; determining the motion information of the upper abdominal epidermis of the subject according to the initial spatial position information and the real-time spatial position information of the upper abdominal epidermis of the subject; and determining the movement information of the upper chest epidermis of the subject according to the initial spatial position information and the real-time spatial position information of the upper chest epidermis of the subject.
In some of these embodiments, the potential change information of the subject surface includes potential change information of the subject's sternum area, potential change information of the subject's apex area, and potential change information of the subject's carotid artery area; determining potential change information of the surface of the subject according to the change amounts of the magnetic field information detected by the diamond NV color center sensors comprises: and respectively determining potential change information of the sternum area of the subject, potential change information of the apex area of the subject and potential change information of the carotid artery area of the subject according to the change amounts of the magnetic field information detected by the diamond NV color center sensors.
In some of these embodiments, detecting magnetic field information of the subject surface by the plurality of diamond NV color center sensors includes: splitting the total magnetic resonance peaks of the diamond NV color centers arranged in each diamond NV color center sensor through a preset magnetic field to obtain four pairs of magnetic resonance peaks, wherein the four pairs of magnetic resonance peaks respectively correspond to the four main shaft directions of the diamond NV color centers; according to the corresponding relation between the splitting width of the magnetic resonance peak and the magnetic field size, respectively determining magnetic field vector information in the main shaft direction corresponding to each pair of the magnetic resonance peaks; and calculating the magnetic field information of the scanned part of the subject detected by each diamond NV color center sensor according to the magnetic field vector information of the four main shaft directions.
In some embodiments, determining the magnetic field vector information in the main axis direction corresponding to each pair of the magnetic resonance peaks according to the correspondence between the magnetic resonance peak cleavage width and the magnetic field magnitude includes: according to the corresponding relation between the splitting width of the magnetic resonance peak and the size of the magnetic field, calculating color center magnetic field vector information of the diamond NV color center in the directions of four principal axes respectively; and calculating the magnetic field vector information of the preset magnetic field in the directions of four principal axes according to the color center magnetic field vector information.
In a second aspect, embodiments of the present application provide a magnetic resonance imaging system comprising: a magnetic resonance scanner having a bore with an imaging field of view; and a processor configured to operate the magnetic resonance scanner when the subject is located therein, perform a diagnostic scan by acquiring magnetic resonance signals from a region of interest of the subject; a memory storing a computer program; and a plurality of diamond NV color center sensors disposed on the subject's region of interest; the processor is further configured to run the computer program to perform the physiological signal detection method as described in the first aspect above applied to magnetic resonance imaging.
In a third aspect, an embodiment of the present application provides an electronic device, including a memory, a processor, and a computer program stored on the memory and executable on the processor, where the processor executes the computer program to implement a physiological signal detection method applied to magnetic resonance imaging as described in the first aspect.
In a fourth aspect, embodiments of the present application provide a storage medium having stored thereon a computer program which, when executed by a processor, implements a physiological signal detection method for magnetic resonance imaging as described in the first aspect above.
Compared with the related art, the physiological signal detection method, the magnetic resonance imaging system, the electronic device and the storage medium applied to the magnetic resonance imaging solve the problem of low detection accuracy of the physiological signal of the testee in the related art, and achieve the technical effect of improving the detection accuracy of the physiological signal of the testee.
The details of one or more embodiments of the application are set forth in the accompanying drawings and the description below to provide a more thorough understanding of the other features, objects, and advantages of the application.
Drawings
The accompanying drawings, which are included to provide a further understanding of the application and are incorporated in and constitute a part of this application, illustrate embodiments of the application and together with the description serve to explain the application and do not constitute an undue limitation to the application. In the drawings:
Figure 1 is a schematic diagram of a magnetic resonance imaging system according to an embodiment of the present application;
FIG. 2 is a flow chart of a physiological signal detection method applied to magnetic resonance imaging according to an embodiment of the present application;
FIG. 3 is a schematic illustration of a first photodetection magnetic resonance map in accordance with an embodiment of the present application;
figure 4 is a schematic diagram of a second photodetection magnetic resonance atlas according to an embodiment of the present application;
fig. 5 is a schematic diagram of a hardware structure of an electronic device according to an embodiment of the present application.
Detailed Description
In order to make the objects, technical solutions and advantages of the present application more apparent, the present application is described and illustrated below with reference to the accompanying drawings and examples. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the present application. All other embodiments, which can be made by one of ordinary skill in the art without undue burden on the person of ordinary skill in the art based on the embodiments provided herein, are intended to be within the scope of the present application. Moreover, it should be appreciated that while such a development effort might be complex and lengthy, it would nevertheless be a routine undertaking of design, fabrication, or manufacture for those of ordinary skill having the benefit of this disclosure, and thus should not be construed as having the benefit of this disclosure.
Reference in the specification to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment may be included in at least one embodiment of the application. The appearances of such phrases in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. It is to be expressly and implicitly understood by those of ordinary skill in the art that the embodiments described herein can be combined with other embodiments without conflict.
Unless defined otherwise, technical or scientific terms used herein should be given the ordinary meaning as understood by one of ordinary skill in the art to which this application belongs. Reference to "a," "an," "the," and similar terms herein do not denote a limitation of quantity, but rather denote the singular or plural. The terms "comprising," "including," "having," and any variations thereof, are intended to cover a non-exclusive inclusion; for example, a process, method, system, article, or apparatus that comprises a list of steps or modules (elements) is not limited to only those steps or elements but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus. The terms "connected," "coupled," and the like in this application are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. The term "plurality" as used herein means greater than or equal to two. "and/or" describes an association relationship of an association object, meaning that there may be three relationships, e.g., "a and/or B" may mean: a exists alone, A and B exist together, and B exists alone. The terms "first," "second," "third," and the like, as used herein, are merely distinguishing between similar objects and not representing a particular ordering of objects.
The systems and methods of the present application are applicable not only to non-invasive imaging, but the processing systems of the present application may include magnetic resonance imaging systems (MR systems), positron emission computed tomography-magnetic resonance multi-modality hybrid systems (PET-MR systems), and the like. The methods, apparatus, systems, or storage media described herein may be integral to or separate from the processing systems described above.
Embodiments of the present application will be described below by taking a magnetic resonance imaging system as an example.
The embodiment of the application provides a magnetic resonance imaging system. Fig. 1 is a schematic structural diagram of a magnetic resonance imaging system according to an embodiment of the present application, as shown in fig. 1, the magnetic resonance imaging system includes: a scanner and a computer, wherein the computer comprises a memory 125, a processor 122 and a computer program stored on the memory 125 and executable on the processor 122. Wherein the processor 122 is configured to run a computer program to perform a physiological signal detection method of an embodiment of the present application applied to magnetic resonance imaging.
A plurality of diamond NV (Nitrogen Vacancy, simply referred to as NV) color center sensors 107 may be further disposed on the region of interest of the imaging object 150, and at least three diamond NV color center sensors 107 are disposed, for example, when the imaging object 150 is subjected to a chest-abdomen scan, three diamond NV color center sensors 107 may be disposed in a chest region or an abdomen region of the imaging object 150, and respiratory signals of the imaging object 150 are monitored by the diamond NV color center sensors 107; alternatively, a diamond NV color center sensor 107 is provided in each of the sternum area, apex area and carotid artery area of the imaging subject 150, and the electrocardiographic signals of the imaging subject 150 are monitored by the diamond NV color center sensor 107.
In some embodiments, a plurality of diamond NV color center sensors 107 may be further disposed on the local coil 104, where the diamond NV color center sensors 107 may be disposed on an inner surface or an outer surface of the local coil 104, and four or more diamond NV color center sensors 107 may be disposed on the local coil 104, and the plurality of diamond NV color center sensors 107 collect magnetic field change information of the region of interest of the imaging object 150 together, so as to monitor physiological signals of the imaging object 150, thereby being beneficial to removing noise and improving accuracy of detecting physiological signals of the subject.
The scanner has a bore with an imaging field of view, which typically includes a magnetic resonance gantry within which is a main magnet 101, the main magnet 101 may be formed of superconducting coils for generating a static magnetic field, and in some cases permanent magnets may be employed. The main magnet 101 may be used to generate a static magnetic field strength of 0.2 tesla, 0.5 tesla, 1.0 tesla, 1.5 tesla, 3.0 tesla, or higher. In magnetic resonance imaging, the subject 150 is carried by the patient table 106, and the subject 150 is moved into the region 105 where the static magnetic field is more uniformly distributed as the table moves. Typically for a magnetic resonance imaging system, as shown in fig. 1, the z-direction of the spatial coordinate system (i.e. the coordinate system of the magnetic resonance imaging system) is set to be the same as the axial direction of the gantry of the magnetic resonance imaging system, the patient's length direction is usually kept consistent with the z-direction for imaging, the horizontal plane of the magnetic resonance imaging system is set to be the xz-plane, the x-direction is perpendicular to the z-direction, and the y-direction is perpendicular to both the x-and z-directions.
In magnetic resonance imaging, the pulse control unit 111 controls the rf pulse generation unit 116 to generate rf pulses, and the rf pulses are amplified by the amplifier, passed through the switch control unit 117, and finally emitted by the body coil 103 or the local coil 104 to perform rf excitation on the imaging object 150. The imaging subject 150 generates corresponding radio frequency signals from resonance upon radio frequency excitation. When receiving the radio frequency signals generated by the imaging object 150 according to excitation, the body coil 103 or the local coil 104 can receive the radio frequency signals, and the radio frequency receiving links can have a plurality of radio frequency receiving links, and the radio frequency signals are further sent to the image reconstruction unit 121 for image reconstruction after being sent to the radio frequency receiving unit 118, so as to form a magnetic resonance image.
The magnetic resonance scanner also includes gradient coils 102 that may be used to spatially encode the radio frequency signals during magnetic resonance imaging. The pulse control unit 111 controls the gradient signal generating unit 112 to generate a gradient signal, which is generally divided into three mutually orthogonal direction signals: gradient signals in the x direction, the y direction and the z direction are amplified by gradient amplifiers (113, 114, 115), and then emitted by the gradient coil 102, so as to generate a gradient magnetic field in the region 105.
The pulse control unit 111, the image reconstruction unit 121, the processor 122, the display unit 123, the input/output device 124, the memory 125 and the communication port 126 can perform data transmission through the communication bus 127, so as to realize the control of the magnetic resonance imaging process.
The processor 122 may be comprised of one or more processors, may include a Central Processing Unit (CPU), or an application specific integrated circuit (Application Specific Integrated Circuit, abbreviated as ASIC), or may be configured to implement one or more integrated circuits of embodiments of the present application.
Among them, the display unit 123 may be a display provided to a user to display an image.
The input/output device 124 may be a keyboard, a mouse, a control box, etc., and supports input/output of corresponding data streams.
Memory 125 may include, among other things, mass storage for data or instructions. By way of example, and not limitation, memory 125 may include a Hard Disk Drive (HDD), floppy Disk Drive, flash memory, optical Disk, magneto-optical Disk, magnetic tape, or universal serial bus (Universal Serial Bus, USB) Drive, or a combination of two or more of these. The memory 125 may include removable or non-removable (or fixed) media, where appropriate. The memory 125 may be internal or external to the data processing apparatus, where appropriate. In a particular embodiment, the memory 125 is a non-volatile solid-state memory. In particular embodiments, memory 125 includes Read Only Memory (ROM). The ROM may be mask programmed ROM, programmable ROM (PROM), erasable PROM (EPROM), electrically Erasable PROM (EEPROM), electrically rewritable ROM (EAROM), or flash memory, or a combination of two or more of these, where appropriate. Memory 125 may be used to store various data files that need to be processed and/or used for communication, as well as possible program instructions for execution by processor 122. When the processor 122 executes a specified program stored in the memory 125, the processor 122 can execute the physiological signal detection method applied to magnetic resonance imaging as proposed by the present application.
Among other things, the communication port 126 may enable, among other components, for example: and the external equipment, the image acquisition equipment, the database, the external storage, the image processing workstation and the like are used for data communication.
Wherein the communication bus 127 comprises hardware, software, or both, that couple the components of the magnetic resonance imaging system to each other. By way of example, and not limitation, the buses may include an Accelerated Graphics Port (AGP) or other graphics bus, an Enhanced Industry Standard Architecture (EISA) bus, a Front Side Bus (FSB), a HyperTransport (HT) interconnect, an Industry Standard Architecture (ISA) bus, an infiniband interconnect, a Low Pin Count (LPC) bus, a memory bus, a micro channel architecture (MCa) bus, a Peripheral Component Interconnect (PCI) bus, a PCI-Express (PCI-X) bus, a Serial Advanced Technology Attachment (SATA) bus, a video electronics standards association local (VLB) bus, or other suitable bus, or a combination of two or more of the above. Communication bus 127 may include one or more buses, where appropriate. Although embodiments of the present application describe and illustrate a particular bus, the present application contemplates any suitable bus or interconnect.
In some of these embodiments, the processor 122 is configured to detect magnetic field information of the subject surface by a plurality of diamond NV color center sensors, wherein the plurality of diamond NV color center sensors are disposed at different locations on the subject surface; a physiological signal of the subject is determined based on the amount of change in the magnetic field information detected by the plurality of diamond NV color center sensors.
In some of these embodiments, the physiological signal includes a respiratory signal and an electrocardiographic signal; the processor 122 is configured to determine motion information of the subject surface based on the amount of change in magnetic field information detected by the plurality of diamond NV color center sensors, if the physiological signal comprises a respiratory signal; determining a respiration signal of the subject according to the motion information of the surface of the subject; determining potential change information of the surface of the subject according to the change amounts of the magnetic field information detected by the diamond NV color center sensors under the condition that the physiological signal comprises an electrocardiosignal; and determining electrocardiosignals of the tested person according to the potential change information of the tested person surface.
In some of these embodiments, the movement information of the subject surface includes movement information of the subject's abdominal upper epidermis and movement information of the subject's thoracic upper epidermis; the processor 122 is configured to determine initial spatial location information for each diamond NV color center sensor based on the magnetic field information detected by each diamond NV color center sensor; according to the change of the magnetic field information detected by each diamond NV color center sensor, real-time spatial position information of each diamond NV color center sensor is respectively determined; and determining the motion information of the upper epidermis of the abdomen of the subject and the motion information of the upper epidermis of the chest of the subject according to the initial spatial position information and the real-time spatial position information of each diamond NV color center sensor.
In some of these embodiments, the processor 122 is configured to determine initial spatial position information and real-time spatial position information of the subject's abdomen upper epidermis and initial spatial position information and real-time spatial position information of the subject's chest upper epidermis, respectively, from the initial spatial position information and real-time spatial position information of each diamond NV color center sensor; determining the motion information of the upper abdominal epidermis of the subject according to the initial spatial position information and the real-time spatial position information of the upper abdominal epidermis of the subject; and determining the movement information of the upper chest epidermis of the subject according to the initial spatial position information and the real-time spatial position information of the upper chest epidermis of the subject.
In some of these embodiments, the potential change information of the subject surface includes potential change information of a subject's sternum area, potential change information of a subject's apex area, and potential change information of a subject's carotid artery area; the processor 122 is configured to determine potential variation information of the subject's sternum area, potential variation information of the subject's apex area, and potential variation information of the subject's carotid artery area, respectively, based on the amounts of variation of the magnetic field information detected by the plurality of diamond NV color center sensors.
In some embodiments, the processor 122 is configured to cleave the total magnetic resonance peaks of the diamond NV color center disposed in each diamond NV color center sensor by a preset magnetic field to obtain four pairs of magnetic resonance peaks, wherein the four pairs of magnetic resonance peaks respectively correspond to four main axis directions of the diamond NV color center; according to the corresponding relation between the splitting width of the magnetic resonance peak and the magnetic field size, respectively determining magnetic field vector information in the main shaft direction corresponding to each pair of magnetic resonance peaks; and calculating the magnetic field information of the scanned part of the subject detected by each diamond NV color center sensor according to the magnetic field vector information of the four main axis directions.
In some embodiments, the processor 122 is configured to calculate color center magnetic field vector information of the diamond NV color center in the four principal axis directions according to the correspondence between the magnetic resonance peak cleavage width and the magnetic field magnitude; according to the color center magnetic field vector information, calculating to obtain magnetic field vector information of the preset magnetic field in the directions of four principal axes.
The present embodiment provides a physiological signal detection method applied to magnetic resonance imaging, and fig. 2 is a flowchart of a physiological signal detection method applied to magnetic resonance imaging according to an embodiment of the present application, as shown in fig. 2, and the flowchart includes the following steps:
In step S201, magnetic field information of the surface of the subject is detected by a plurality of diamond NV color center sensors, wherein the plurality of diamond NV color center sensors are disposed at different positions on the surface of the subject.
Step S202, determining physiological signals of the testee according to the change amount of the magnetic field information detected by the diamond NV color center sensors.
In this embodiment, the physiological signal of the subject includes, but is not limited to, at least one of: the respiratory signal and the electrocardiosignal, the diamond NV color center sensor can be arranged on the surface of the testee, and at least three diamond NV color center sensors are arranged, for example, when the testee is subjected to chest and abdomen scanning, three diamond NV color center sensors can be arranged in the chest area or the abdomen area of the testee, and the respiratory signal of the testee can be monitored through the diamond NV color center sensors; alternatively, a diamond NV color center sensor is provided in each of the sternum area, apex area and carotid artery area of the subject, and the electrocardiographic signal of the subject is monitored by the diamond NV color center sensor.
Currently, magnetic measurement techniques based on diamond NV color centers have many advantages over traditional magnetic measurement techniques, such as hall effect sensors, magnetic force microscopes, etc: the working temperature range is wide, the spatial resolution and the sensitivity are high, and meanwhile, the magnetic field of the sample is not disturbed.
On the other hand, as a sensor, the diamond NV color center can approach to a sample to be measured to a nanometer level due to the size of the atomic scale, and measurement of single electron spin and single nuclear spin can be realized by combining the advantage of high sensitivity.
Therefore, with reference to the conventional magnetic resonance technology, the diamond NV color center can realize single-molecule nuclear magnetic resonance and single-molecule paramagnetic resonance, and the magnetic measurement technology based on the diamond NV color center is often applied to magnetic and magnetic material research.
However, the diamond NV color center sensor is not applied to detecting physiological signals of a human body in a magnetic resonance environment, and in the related art, a traditional way of monitoring respiration is to bind an abdominal belt with a pressure sensor on the abdomen of a subject, and obtain changes of the pressure signal of the abdominal belt caused by respiration to monitor respiratory motion; or acquiring signal changes caused by respiration by adopting a special magnetic resonance navigation sequence in magnetic resonance imaging to monitor respiratory motion; the heartbeat electric signal monitoring is realized by attaching electrodes to the body surface of the detected person. However, such solutions are less accurate and it is difficult to achieve detection of the subject's respiratory and heartbeat signals in a harsh environment (e.g., a magnetic resonance environment).
Compared with the traditional physiological signal detection technology, in the physiological signal detection method based on the diamond NV color center sensor, the size of the diamond NV color center sensor is very small and can reach 1mm 3 The precision and dynamic range are higher, the measured frequency bandwidth can also meet the requirements, the magnetic field information can be measured in real time under the magnetic resonance environment, a diamond NV color center sensor can be respectively arranged above the sternum, above the fifth intercostal apex and near the neck of the right carotid artery of a subject, and due to myocardial contraction, aortic expansion and valve closure, tiny potential changes exist above the sternum, above the fifth intercostal apex and near the right carotid artery of the subject, the tiny potential changes can cause the magnetic field changes, the tiny magnetic field changes can be detected by the diamond NV color center sensor, and then the potential change information of the sternum area of the subject, the potential change information of the apex area of the subject and the carotid artery of the subject are obtainedAnd according to the potential change information of the region, the electrocardiosignals of the detected person are acquired more accurately.
In some embodiments, detecting magnetic field information of a scanned region of a subject by a plurality of diamond NV color center sensors comprises the steps of:
And step 1, splitting the total magnetic resonance peaks of the diamond NV color centers arranged in each diamond NV color center sensor through a preset magnetic field to obtain four pairs of magnetic resonance peaks, wherein the four pairs of magnetic resonance peaks respectively correspond to the four main shaft directions of the diamond NV color centers.
And 2, respectively determining magnetic field vector information in the main axis direction corresponding to each pair of magnetic resonance peaks according to the corresponding relation between the splitting width of the magnetic resonance peaks and the magnetic field size.
And 3, calculating the magnetic field information of the scanned part of the subject detected by each diamond NV color center sensor according to the magnetic field vector information in the directions of the four main shafts.
In this embodiment, the four principal axis directions may correspond to the four crystal axis directions of the diamond lattice structure, i.e., (111), (1-11), (-111) and (11-1), respectively.
Fig. 3 is a schematic diagram of a first optical detection magnetic resonance spectrum according to an embodiment of the present application, in which the Y-axis is fluorescence intensity (Fluorescence intensity), the X-axis is probe microwave frequency (Probe microwave frequency), and the unit is (MHz), and as shown in fig. 3, four pairs of magnetic resonance peaks of a, b, c, d can be obtained by splitting a total magnetic resonance peak of a diamond NV color center set in a diamond NV color center sensor through a preset magnetic field, each pair of left and right two magnetic resonance peaks are separated from the center of eight magnetic resonance peaks, the center point in the figure is 2.87GHz, and each pair of magnetic resonance peaks corresponds to four main axis directions of a diamond NV color center in a carbon lattice.
FIG. 4 is a schematic diagram of a second optical detection magnetic resonance spectrum according to an embodiment of the present application, in which the Y-axis is fluorescence intensity (Fluorescence intensity), the X-axis is probe microwave frequency (Probe microwave frequency), and the unit is (MHz), and as shown in FIG. 4, the correspondence between each pair of magnetic resonance peaks can be determined according to the correspondence between the splitting width of the magnetic resonance peak and the size of the magnetic fieldFor example, the magnetic field vector information in the main axis direction: in a corresponding relationship f ± ＝2γB z For example, where f ± ＝f + -f - I.e. the cleavage width of the pair of magnetic resonance peaks, f + The microwave frequency f of the probe for the right magnetic resonance peak in the pair of magnetic resonance peaks - For the probe microwave frequency of the left Bian Ci resonance peak in the pair of magnetic resonance peaks, gamma is the gyromagnetic ratio of the diamond NV color center, B z The magnetic field vector information of the preset magnetic field in the Z-axis direction can be obtained through the corresponding relation, wherein Deltav in the figure is the central line width, and C is the fluorescence intensity of the actually measured magnetic resonance peak.
In some of these embodiments, determining the magnetic field vector information in the principal axis direction corresponding to each pair of magnetic resonance peaks, respectively, according to the correspondence between the magnetic resonance peak cleavage width and the magnetic field magnitude includes: according to the corresponding relation between the splitting width of the magnetic resonance peak and the size of the magnetic field, calculating and obtaining color center magnetic field vector information of the diamond NV color center in the directions of four principal axes respectively; according to the color center magnetic field vector information, calculating to obtain magnetic field vector information of the preset magnetic field in the directions of four principal axes.
In this embodiment, after the color center magnetic field vector information of the diamond NV color center in the carbon lattice in the four principal axis directions is obtained, the color center magnetic field vector information of the diamond NV color center in the carbon lattice in the four principal axis directions is calculated, so that the magnetic field vector information of the preset magnetic field in the four principal axis directions can be comprehensively obtained, and the magnetic field information of the scanned part of the subject is further obtained.
In some of these embodiments, determining the physiological signal of the subject surface based on the amount of change in magnetic field information detected by the plurality of diamond NV color center sensors comprises the steps of:
step 1, determining movement information of the surface of the subject according to the change amount of the magnetic field information detected by the diamond NV color center sensors when the physiological signal comprises a respiratory signal.
And 2, determining a respiration signal of the subject according to the motion information of the surface of the subject.
And 3, when the physiological signal comprises an electrocardiosignal, determining potential change information of the surface of the subject according to the change amounts of the magnetic field information detected by the diamond NV color center sensors.
And 4, determining electrocardiosignals of the testee according to the potential change information of the surface of the testee.
In this embodiment, a plurality of diamond NV color center sensors may be disposed on an upper abdominal surface or an upper chest surface of the subject, and according to respiratory signals of the subject detected by the plurality of diamond NV color center sensors, initial spatial position information of each diamond NV color center sensor may be determined respectively according to magnetic field information detected by each diamond NV color center sensor and magnetic field distribution information of the magnetic resonance imaging system, and real-time spatial position information of each diamond NV color center sensor may be determined respectively according to variation of real-time magnetic field information detected by each diamond NV color center sensor and magnetic field distribution information of the magnetic resonance imaging system, and finally motion information of the upper chest surface of the subject and motion information of the upper chest surface of the subject may be determined according to the initial spatial position information and the real-time spatial position information of each diamond NV color center sensor.
In the case of performing a magnetic resonance coronary clinical examination of a subject, motion information corresponding to a chest upper epidermis region may be acquired by a plurality of diamond NV color center sensors, and chest upper epidermis up-and-down motion amplitude values of the subject may be extracted from the motion information corresponding to the chest upper epidermis region, so as to monitor chest motion of the subject due to respiration.
When a subject is subjected to a magnetic resonance abdominal scene clinical examination, motion information corresponding to an abdominal epicutaneous region is acquired by a plurality of diamond NV color center sensors, and an abdominal epicutaneous up-and-down motion amplitude value of the subject is extracted from the motion information corresponding to the abdominal epicutaneous region, so as to monitor the abdominal motion of the subject.
In other embodiments, other locations may also be monitored, for example: in respiratory movement of human body, contraction and expansion of alveoli can drive movement of liver, so that upper epidermis region corresponding to liver of subject can be monitored.
In this embodiment, the initial spatial position information and the real-time spatial position information of the diamond NV color center sensor may include one or more sets of three-dimensional coordinate data located under a physical coordinate system, where the physical coordinate system is a space rectangular coordinate system, and includes: x-axis, Y-axis and Z-axis. The initial spatial position information and the real-time spatial position information of the diamond NV color center sensor at least comprise 7 components, namely: the center position of the layer on the X axis, the center position of the layer on the Y axis, the center position of the layer on the Z axis, the normal vector of the X axis, the normal vector of the Y axis, the normal vector of the Z axis and the rotation angle in the layer.
Through the coordinate data in the real-time space position information and the coordinate data in the initial space position information, the motion information of the diamond NV color center sensor can be more conveniently and accurately obtained through coordinate calculation.
In this embodiment, the initial spatial position information and the real-time spatial position information of the upper surface of the abdomen of the subject and the initial spatial position information and the real-time spatial position information of the upper surface of the chest of the subject may be determined according to the initial spatial position information and the real-time spatial position information of each diamond NV color center sensor, the motion information of the upper surface of the abdomen of the subject may be determined according to the initial spatial position information and the real-time spatial position information of the upper surface of the abdomen of the subject, and the motion information of the upper surface of the chest of the subject may be determined according to the initial spatial position information and the real-time spatial position information of the upper surface of the chest of the subject.
The initial spatial position information and the real-time spatial position information of the upper abdominal epidermis of the subject and the upper chest epidermis of the subject can also be one or more groups of three-dimensional coordinate data positioned under a physical coordinate system, and the motion information of the upper abdominal epidermis of the subject and the upper chest epidermis of the subject can be more conveniently and accurately obtained through coordinate calculation by the coordinate data in the real-time spatial position information and the coordinate data in the initial spatial position information.
In this embodiment, the motion information may include the degree and the number of motions of the scan portion of the subject, and motion vector information under a physical coordinate system corresponding to each motion, or the motion information of the upper epidermis of the abdomen of the subject may be an up-and-down motion amplitude value of the upper epidermis of the abdomen of the subject, and the motion information of the upper epidermis of the chest of the subject may be an up-and-down motion amplitude value of the upper epidermis of the chest of the subject.
The initial spatial position information and the real-time spatial position information of the upper epidermis of the abdomen and the upper epidermis of the chest of the subject can be directly fed back to a sequence time sequence control unit in the magnetic resonance imaging system, the sequence time sequence control unit can run a scanning sequence, and scanning parameters in the scanning sequence are transmitted to the gradient component and the radio frequency component, so that the gradient component and the radio frequency component perform magnetic resonance scanning according to the received scanning parameters.
After the initial spatial position information and the real-time spatial position information of the upper abdominal epidermis of the testee and the upper thoracic epidermis of the testee are fed back to a sequence time sequence control unit in the magnetic resonance imaging system, an identification position can be additionally arranged in a scanning sequence, and when the scanning sequence is operated to the identification position, the trigger sequence time sequence control unit obtains the initial spatial position information and the real-time spatial position information of the upper abdominal epidermis of the testee and the upper thoracic epidermis of the testee, so that the acquisition of the motion information and the acquisition of the magnetic resonance data of the upper abdominal epidermis of the testee and the upper thoracic epidermis of the testee are mutually independent.
In some of these embodiments, the potential change information of the subject surface includes potential change information of a subject's sternum area, potential change information of a subject's apex area, and potential change information of a subject's carotid artery area; determining potential change information of the surface of the subject based on the amounts of change in the magnetic field information detected by the plurality of diamond NV color center sensors includes: the potential change information of the sternum area of the subject, the potential change information of the apex area of the subject and the potential change information of the carotid artery area of the subject are respectively determined according to the change amounts of the magnetic field information detected by the diamond NV color center sensors.
In this embodiment, the diamond NV color center sensor has a smaller size, which can reach 7mm×7mm×1.5mm, and has a higher accuracy and dynamic range, the magnetic field information can be measured in real time in the magnetic resonance environment, one diamond NV color center sensor can be respectively disposed above the sternum, above the fifth intercostal space apex and near the neck of the right carotid artery of the subject, and due to the myocardial contraction, the aortic expansion and the valve closure, there is a small potential change above the sternum, above the fifth intercostal space apex and near the right carotid artery of the subject, and the small potential change can cause a change in magnetic field, and the small magnetic field changes can be detected by the diamond NV color center sensor, so as to obtain the potential change information of the sternum area of the subject, the potential change information of the apex area of the heart of the subject and the potential change information of the carotid artery area of the subject, and obtain the electrocardiosignal of the subject according to the potential change information.
Through the steps S201 to S202, the magnetic field information on the surface of the subject is detected by the plurality of diamond NV color center sensors, wherein the plurality of diamond NV color center sensors are arranged at different positions on the surface of the subject, and the physiological signal of the subject is determined according to the variation of the magnetic field information detected by the plurality of diamond NV color center sensors. By the method and the device, the problem of low detection accuracy of the physiological signals of the testee in the related technology is solved, and the technical effect of improving the accuracy of detecting the physiological signals of the testee is achieved.
The present embodiment also provides an electronic device, and fig. 5 is a schematic diagram of a hardware structure of the electronic device according to an embodiment of the present application, and as shown in fig. 5, the device includes a memory 504 and a processor 502, where the memory 504 stores a computer program, and the processor 502 is configured to execute the computer program to perform steps in any one of the method embodiments described above.
In particular, the processor 502 may include a Central Processing Unit (CPU), or an application specific integrated circuit (Application Specific Integrated Circuit, abbreviated as ASIC), or may be configured to implement one or more integrated circuits of embodiments of the present application.
Wherein the memory 504 may include mass storage 504 for data or instructions. By way of example, and not limitation, memory 504 may comprise a Hard Disk Drive (HDD), floppy Disk Drive, solid state Drive (Solid State Drive, SSD), flash memory, optical Disk, magneto-optical Disk, tape, or universal serial bus (Universal Serial Bus, USB) Drive, or a combination of two or more of the foregoing. The memory 504 may include removable or non-removable (or fixed) media, where appropriate. The memory 504 may be internal or external to the data processing apparatus, where appropriate. In a particular embodiment, the memory 504 is a Non-Volatile (Non-Volatile) memory. In a particular embodiment, the Memory 504 includes Read-Only Memory (ROM) and random access Memory (Random Access Memory, RAM). Where appropriate, the ROM may be a mask-programmed ROM, a programmable ROM (Programmable Read-Only Memory, abbreviated PROM), an erasable PROM (Erasable Programmable Read-Only Memory, abbreviated EPROM), an electrically erasable PROM (Electrically Erasable Programmable Read-Only Memory, abbreviated EEPROM), an electrically rewritable ROM (Electrically Alterable Read-Only Memory, abbreviated EAROM), or a FLASH Memory (FLASH), or a combination of two or more of these. The RAM may be Static Random-Access Memory (SRAM) or dynamic Random-Access Memory (Dynamic Random Access Memory DRAM), where the DRAM may be flash-mode dynamic Random-Access Memory 504 (Fast Page Mode Dynamic Random Access Memory FPMDRAM), extended-data-output dynamic Random-Access Memory (Extended Date Out Dynamic Random Access Memory EDODRAM), synchronous dynamic Random-Access Memory (Synchronous Dynamic Random-Access Memory SDRAM), or the like, as appropriate.
Memory 504 may be used to store or cache various data files that need to be processed and/or used for communication, as well as possible computer program instructions for execution by processor 502.
The processor 502 implements any of the above-described embodiments of the physiological signal detection method applied to magnetic resonance imaging by reading and executing computer program instructions stored in the memory 504.
Optionally, the electronic apparatus may further include a transmission device 506 and an input/output device 508, where the transmission device 506 is connected to the processor 502 and the input/output device 508 is connected to the processor 502.
Alternatively, in this embodiment, the processor 502 may be configured to execute the following steps by a computer program:
s1, detecting magnetic field information of the surface of a subject through a plurality of diamond NV color center sensors, wherein the diamond NV color center sensors are arranged at different positions of the surface of the subject.
S2, determining physiological signals of the testee according to the change amount of the magnetic field information detected by the diamond NV color center sensors.
It should be noted that, specific examples in this embodiment may refer to examples described in the foregoing embodiments and alternative implementations, and this embodiment is not repeated herein.
In addition, in combination with the physiological signal detection method applied to magnetic resonance imaging in the above embodiment, the embodiments of the present application may provide a storage medium for implementation. The storage medium has a computer program stored thereon; the computer program, when executed by a processor, implements any of the above embodiments of a physiological signal detection method applied to magnetic resonance imaging.
It should be understood by those skilled in the art that the technical features of the above-described embodiments may be combined in any manner, and for brevity, all of the possible combinations of the technical features of the above-described embodiments are not described, however, they should be considered as being within the scope of the description provided herein, as long as there is no contradiction between the combinations of the technical features.
The above examples merely represent a few embodiments of the present application, which are described in more detail and are not to be construed as limiting the scope of the invention. It should be noted that it would be apparent to those skilled in the art that various modifications and improvements could be made without departing from the spirit of the present application, which would be within the scope of the present application. Accordingly, the scope of protection of the present application is to be determined by the claims appended hereto.
Claims (9)
1. A physiological signal detection method applied to magnetic resonance imaging, comprising:
detecting magnetic field information of the surface of the subject by a plurality of diamond NV color center sensors, wherein the diamond NV color center sensors are arranged at different positions of the surface of the subject;
determining physiological signals of the testee according to the change amount of the magnetic field information detected by the diamond NV color center sensors; wherein the physiological signal comprises a respiratory signal and an electrocardiographic signal; determining a physiological signal of the subject surface based on the amount of change in magnetic field information detected by the plurality of diamond NV color center sensors comprises:
determining movement information of the surface of the subject according to the change amount of the magnetic field information detected by the diamond NV color center sensors under the condition that the physiological signal comprises a respiratory signal;
determining a respiration signal of the subject according to the motion information of the surface of the subject;
determining potential change information of the surface of the subject according to the change amounts of the magnetic field information detected by the diamond NV color center sensors under the condition that the physiological signal comprises an electrocardiosignal;
And determining electrocardiosignals of the tested person according to the potential change information of the tested person surface.
2. The method for detecting physiological signals applied to magnetic resonance imaging according to claim 1, wherein the motion information of the subject surface includes motion information of an upper epidermis of an abdomen of the subject and motion information of an upper epidermis of a chest of the subject; determining motion information of the surface of the subject according to the change amount of the magnetic field information detected by the diamond NV color center sensors comprises:
according to the magnetic field information detected by each diamond NV color center sensor, initial spatial position information of each diamond NV color center sensor is respectively determined;
according to the change of the magnetic field information detected by each diamond NV color center sensor, real-time spatial position information of each diamond NV color center sensor is respectively determined;
and determining the motion information of the upper epidermis of the abdomen of the subject and the motion information of the upper epidermis of the chest of the subject according to the initial spatial position information and the real-time spatial position information of each diamond NV color center sensor.
3. The method for detecting physiological signals applied to magnetic resonance imaging according to claim 2, wherein determining the motion information of the subject's abdomen upper epidermis and the motion information of the subject's chest upper epidermis based on the initial spatial position information and the real-time spatial position information of each of the diamond NV color center sensors comprises:
According to the initial spatial position information and the real-time spatial position information of each diamond NV color center sensor, respectively determining the initial spatial position information and the real-time spatial position information of the upper surface of the abdomen of the detected person and the initial spatial position information and the real-time spatial position information of the upper surface of the chest of the detected person;
determining the motion information of the upper abdominal epidermis of the subject according to the initial spatial position information and the real-time spatial position information of the upper abdominal epidermis of the subject;
and determining the movement information of the upper chest epidermis of the subject according to the initial spatial position information and the real-time spatial position information of the upper chest epidermis of the subject.
4. The physiological signal detection method applied to magnetic resonance imaging according to claim 1, wherein the potential change information of the subject surface includes potential change information of a sternum region of the subject, potential change information of a apex region of the subject, and potential change information of a carotid artery region of the subject; determining potential change information of the surface of the subject according to the change amounts of the magnetic field information detected by the diamond NV color center sensors comprises:
And respectively determining potential change information of the sternum area of the subject, potential change information of the apex area of the subject and potential change information of the carotid artery area of the subject according to the change amounts of the magnetic field information detected by the diamond NV color center sensors.
5. The method for detecting physiological signals applied to magnetic resonance imaging according to claim 1, wherein detecting magnetic field information of a subject surface by a plurality of diamond NV color center sensors includes:
splitting the total magnetic resonance peaks of the diamond NV color centers arranged in each diamond NV color center sensor through a preset magnetic field to obtain four pairs of magnetic resonance peaks, wherein the four pairs of magnetic resonance peaks respectively correspond to the four main shaft directions of the diamond NV color centers;
according to the corresponding relation between the splitting width of the magnetic resonance peak and the magnetic field size, respectively determining magnetic field vector information in the main shaft direction corresponding to each pair of the magnetic resonance peaks;
and calculating the magnetic field information of the scanned part of the subject detected by each diamond NV color center sensor according to the magnetic field vector information of the four main shaft directions.
6. The physiological signal detection method applied to magnetic resonance imaging according to claim 5, wherein determining magnetic field vector information in a main axis direction corresponding to each pair of the magnetic resonance peaks according to a correspondence between a magnetic resonance peak cleavage width and a magnetic field magnitude includes:
According to the corresponding relation between the splitting width of the magnetic resonance peak and the size of the magnetic field, calculating color center magnetic field vector information of the diamond NV color center in the directions of four principal axes respectively;
and calculating the magnetic field vector information of the preset magnetic field in the directions of four principal axes according to the color center magnetic field vector information.
7. A magnetic resonance imaging system, characterized in that the magnetic resonance imaging system comprises: a magnetic resonance scanner having a bore with an imaging field of view; and a processor configured to operate the magnetic resonance scanner when the subject is located therein, perform a diagnostic scan by acquiring magnetic resonance signals from a region of interest of the subject; a memory storing a computer program; and a plurality of diamond NV color center sensors disposed on the subject's region of interest; the processor is further configured to run the computer program to perform the physiological signal detection method applied to magnetic resonance imaging of any one of claims 1 to 6.
8. An electronic device comprising a memory and a processor, wherein the memory has stored therein a computer program, the processor being arranged to run the computer program to perform the physiological signal detection method of any one of claims 1 to 6 applied to magnetic resonance imaging.
9. A storage medium having a computer program stored therein, wherein the computer program is arranged to, when run, perform the physiological signal detection method applied to magnetic resonance imaging of any one of claims 1 to 6.
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