CN112617753A - Transmission-type fluorescence radiography equipment capable of detecting deep lymphatic vessels and lymph nodes - Google Patents
Transmission-type fluorescence radiography equipment capable of detecting deep lymphatic vessels and lymph nodes Download PDFInfo
- Publication number
- CN112617753A CN112617753A CN202011495300.3A CN202011495300A CN112617753A CN 112617753 A CN112617753 A CN 112617753A CN 202011495300 A CN202011495300 A CN 202011495300A CN 112617753 A CN112617753 A CN 112617753A
- Authority
- CN
- China
- Prior art keywords
- light source
- transmission
- probe
- type
- nodes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002601 radiography Methods 0.000 title claims abstract description 14
- 210000001165 lymph node Anatomy 0.000 title claims abstract description 9
- 210000001365 lymphatic vessel Anatomy 0.000 title abstract description 7
- 239000000523 sample Substances 0.000 claims abstract description 36
- 210000002751 lymph Anatomy 0.000 claims abstract description 14
- 238000001514 detection method Methods 0.000 abstract description 21
- 238000001917 fluorescence detection Methods 0.000 abstract description 11
- 210000004907 gland Anatomy 0.000 abstract description 2
- 210000001519 tissue Anatomy 0.000 description 9
- 238000005286 illumination Methods 0.000 description 7
- 230000000694 effects Effects 0.000 description 5
- 230000005540 biological transmission Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 230000005284 excitation Effects 0.000 description 4
- 210000005005 sentinel lymph node Anatomy 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 108060001084 Luciferase Proteins 0.000 description 1
- 239000005089 Luciferase Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000010794 food waste Substances 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000013307 optical fiber Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
The invention relates to the field of medical fluorescence detection, in particular to a transmission-type fluorescence radiography device capable of detecting deep lymphatic vessels and lymph nodes. The utility model provides a can survey transmission-type fluorescence radiography equipment of deep lymph duct and lymph gland, includes detection light source and probe body, detection light source includes the light source main part, the light source main part is rod-shaped structure, and one end is equipped with the luminous body, other end connecting power line, the probe body is equipped with the checkpost, a plurality of positions homoenergetic can be dismantled with the checkpost in the light source main part and be connected. The detection light source is not directly integrated in the probe, so that the structure of the probe is more flexible, and the probe is convenient to adapt to various requirements.
Description
Technical Field
The invention relates to the field of medical fluorescence detection, in particular to a transmission-type fluorescence radiography device capable of detecting deep lymphatic vessels and lymph nodes.
Background
The fluorescence detection is a natural luminescence reaction, and can detect human cells, bacteria, mould and food residues by reacting luciferase with ATP. In the working process of the fluorescence detection equipment, a target needs to be irradiated by a fluorescence detection light source, and then the fluorescence reaction condition is collected by the imaging equipment.
The sentinel lymph nodes and the deep lymph vessels are not fixed in position in the human body, and are tasted to be buried in the subcutaneous deeper part of the human body, and when the relevant parts are searched by using fluorescence detection, the fluorescence detection efficiency is low because the illumination intensity is not enough and the tissues of the human body cannot be penetrated.
The applicant discloses a hand-held human body spontaneous probe in a Chinese invention patent with the patent number of 201910269417.0, wherein the hand-held device integrates a camera and a light-emitting light source, and can realize fluorescence detection at one time. However, in this scheme, because the light source is integrated into the handheld device, and because the handheld device is limited in size, the handheld device cannot be too large in size during medical detection work, so that the light-emitting body of the light source is small, the problem of insufficient illuminance occurs, and the illuminance cannot be adjusted as required, so that the fluorescence detection effect is finally affected. At present, only superficial lymph vessels and lymph nodes close to the skin can be seen in a fluorescence contrast device because a common fluorescence contrast device adopts an excitation light reflection type fluorescence contrast mode, and because human tissues are thick, excitation light is difficult to irradiate from the back of the tissues and penetrate through the tissues. Therefore, no transmission-type fluorescence radiography equipment applied to clinic exists at present.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides the transmission-type fluorescence radiography equipment capable of detecting the deep lymphatic vessels and the lymph nodes.
The scheme provided by the invention is as follows:
the utility model provides a can survey transmission-type fluorescence radiography equipment of deep lymph duct and lymph gland, includes detection light source and probe body, detection light source includes the light source main part, the light source main part is rod-shaped structure, and one end is equipped with the luminous body, other end connecting power line, the probe body is equipped with the checkpost, a plurality of positions homoenergetic can be dismantled with the checkpost in the light source main part and be connected. The detection light source is not directly integrated in the probe, so that the structure of the probe is more flexible, and the probe is convenient to adapt to various requirements.
Preferably, the light source main body is at least partially cylindrical with the same diameter, the clip comprises two arc-shaped elastic arms which are symmetrical left and right, an opening is formed between the two elastic arms, and the light source main body is positioned between the two elastic arms. The two elastic arms clamp the detection light source, so that the fixation of the detection light source is realized, and meanwhile, the connection position of the detection light source can be changed, so that the illumination distance is adjusted, and the illumination intensity under the unit area is adjusted.
Preferably, the probe has no light source inside. The probe does not need to be additionally provided with a light source, so that the volume of the probe can be reduced.
Preferably, the direction of irradiation of the light emitting body is the same as the axial direction of the light source body. The irradiation direction is along the axial direction of the main body, and the directivity is good.
Preferably, the light source body is a rod-shaped structure, and the light emitter is located inside the rod-shaped structure. The irradiation of the detection light source is in a point shape, the rod-shaped light source body is not limited by the volume of the probe, a luminous body with larger power can be adopted, the position of the probe can be adjusted, the illuminance per unit area of the area to be detected can be adjusted through far and near movement, the probe does not need to be moved, and the operation is more flexible. Because the detection light source is a single individual, the volume can be designed to be larger, and more sufficient illumination intensity can be provided.
Preferably, the luminous body is of an annular structure, a plurality of bulbs are arranged on the ring, and the interior of the ring is hollow. The bulb that the annular set up can send annular light, improve holistic illumination intensity under the prerequisite that does not increase single-point light source power, because sentinel lymph node and deep lymph duct bury deeply sometimes, the illumination intensity of single-point is not enough to make light pierce through the human body, cause the burn of human tissue again easily when power is too high, consequently a plurality of bulbs of annular setting can shine through on human surface, make sentinel lymph node or deep lymph duct be located annular middle part, improve illumination intensity through increasing bulb quantity, it is more obvious to make the fluorescence reaction.
The invention has the following beneficial effects:
1. the probe light source is not integrated on the probe, so that the design of the volume and the shape of the probe is more flexible;
2. when the point-shaped light source is adopted, the detection light source can move relative to the probe, when the illuminance in the area to be detected is insufficient, the detection light source can be pushed to improve the illuminance in unit area, and when the illuminance in the area to be detected is overhigh, the detection light source can be pulled away to reduce the illuminance in unit area;
3. when the annular light source is adopted, the annular light source is tightly attached to the skin, so that the fluorescence detection is changed from a reflection type to a transmission type, the interference of reflected light can be effectively removed, the signal to noise ratio is improved, and the transillumination depth is improved;
4. the invention provides an annular laser light source suitable for fluorescence radiography, which irradiates excitation light into tissues from the front, the excitation light is scattered in semitransparent tissues and is transmitted out of the skin, so that transmission-type fluorescence radiography is realized, and compared with a reflection-type fluorescence radiography technology, the transmission-type fluorescence radiography technology has obviously deepened detection depth, so that deep lymphatic vessels and lymph nodes can be detected, and the in-vitro positioning of sentinel lymph node fluorescence detection is realized;
5. because of the consideration to user's security, the laser product can carry out the safety classification according to power, consequently to medical laser equipment, the restriction of power is especially strict, and when laser power was too high, then can surpass the requirement of safety classification, but when power low then can lead to the incident intensity and the penetrability of laser not enough, and can keep under the prerequisite of original safety classification through this scheme, reduce the restriction that power caused through improving optical density.
Drawings
In order to more clearly illustrate the embodiments or technical solutions in the prior art of the present invention, the drawings used in the description of the embodiments or prior art will be briefly described below, and it is obvious for those skilled in the art that other drawings can be obtained based on these drawings without creative efforts.
FIG. 1 is a schematic view of a probe configuration;
FIG. 2 is a schematic view of the probe body construction;
FIG. 3 is a schematic diagram of a detecting light source according to an embodiment;
FIG. 4 is a schematic structural diagram of a second detection light source according to an embodiment;
FIG. 5 is a reflectance fluorescence contrast image;
FIG. 6 is a transmission fluorography image;
fig. 7 is a scattering state of laser light in human tissue.
In the figure, 1-detection light source, 2-probe body, 11-light source main body, 12-luminous body, 13-power line, 21-clip, 22-camera.
Detailed Description
In order to make those skilled in the art better understand the technical solution of the present invention, the technical solution in the embodiment of the present invention will be clearly and completely described below with reference to the drawings in the embodiment of the present invention, and it is obvious that the described embodiment is only a part of the embodiment of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example one
As shown in fig. 1 to fig. 3, the present embodiment provides a transmission-type fluorescence radiography apparatus capable of detecting deep lymphatic vessels and lymph nodes, which includes a probe light source 1 and a probe body 2, wherein the probe light source 1 includes a light source main body 11, the light source main body 11 is of a rod-like structure, one end of the probe light source is provided with a light emitting body 12, the other end of the probe light source is connected to a power line 13, the probe body 2 is provided with a clip 21, and a plurality of positions on the light source main body 11 can be detachably connected to the. One end of the probe body 2 is provided with a camera 22.
The light source body 11 is at least partially cylindrical with the same diameter, the clip 21 comprises two arc-shaped elastic arms which are symmetrical left and right, an opening is formed between the two elastic arms, and the light source body is positioned between the two elastic arms. The probe has no light source inside.
The direction of irradiation of the light emitter 12 is the same as the axial direction of the light source body 11. The light source body 11 is a rod-shaped structure, and the light emitting body 12 is located inside one end of the rod-shaped structure.
Example two
As shown in fig. 4, in the present embodiment, the light-emitting body 12 is a ring structure, 18 bulbs are arranged on the ring, the ring is hollow, and the light-emitting body can be connected to the light source body by the same structure as the clip 21. The other parts of this embodiment are substantially the same as those of the first embodiment.
As shown in fig. 5 and fig. 6, fig. 5 is a reflection fluorescence contrast effect diagram, and fig. 6 is a transmission fluorescence contrast effect diagram, it can be seen that the transmission fluorescence contrast effect is better and clearer, and the detection effect is deeper.
As shown in FIG. 7, the upper right and lower right of the four figures are respectively the scattering state of the laser in the human tissue when the diameter of the annular light source is 20mm,30mm, 40mm and 50mm, and the detection depth is 4.7mm, 8.2mm, 13.3mm and 14.8 mm. The detection depth of the laser radiation increases with increasing diameter, i.e. increasing distance of the optical fiber. The probe depth can be controlled by varying the distance between the fibers.
Although the present invention has been described in detail by referring to the drawings in connection with the preferred embodiments, the present invention is not limited thereto. It will be apparent to those skilled in the art that various changes and modifications can be made without departing from the spirit and scope of the invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (6)
1. A transmission-type fluorescence radiography equipment capable of detecting deep lymph vessels and lymph nodes is characterized in that: including detecting light source and probe body, detecting light source includes the light source main part, the light source main part is shaft-like structure, and one end is equipped with the luminous body, and other end connecting power line, the probe body is equipped with the checkpost, a plurality of positions homoenergetic can be dismantled with the checkpost and be connected in the light source main part.
2. A transmission-type fluorography apparatus for detecting deep lymph vessels and nodes as claimed in claim 1, wherein: the light source body is at least partially cylindrical with the same diameter, the clamp comprises two arc-shaped elastic arms which are symmetrical left and right, an opening is formed between the two elastic arms, and the light source body is located between the two elastic arms.
3. A transmission-type fluorography apparatus for detecting deep lymph vessels and nodes as claimed in claim 1, wherein: the probe has no light source inside.
4. A transmission-type fluorography apparatus for detecting deep lymph vessels and nodes as claimed in claim 1, wherein: the irradiation direction of the luminous body is the same as the axial direction of the light source body.
5. A transmission-type fluorography apparatus for detecting deep lymph vessels and nodes as claimed in claim 2, wherein: the light source main body is of a rod-shaped structure, and the luminous body is located inside the rod-shaped structure.
6. A transmission-type fluorography apparatus for detecting deep lymph vessels and nodes as claimed in claim 2, wherein: the luminous body is of an annular structure, a plurality of bulbs are arranged on the ring, and the ring is hollow.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011495300.3A CN112617753A (en) | 2020-12-17 | 2020-12-17 | Transmission-type fluorescence radiography equipment capable of detecting deep lymphatic vessels and lymph nodes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011495300.3A CN112617753A (en) | 2020-12-17 | 2020-12-17 | Transmission-type fluorescence radiography equipment capable of detecting deep lymphatic vessels and lymph nodes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112617753A true CN112617753A (en) | 2021-04-09 |
Family
ID=75316333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011495300.3A Pending CN112617753A (en) | 2020-12-17 | 2020-12-17 | Transmission-type fluorescence radiography equipment capable of detecting deep lymphatic vessels and lymph nodes |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112617753A (en) |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1749642A (en) * | 2004-09-13 | 2006-03-22 | 冠德光电科技股份有限公司 | External hanging lighting device capable of regulating angle |
| CN1759803A (en) * | 2004-10-12 | 2006-04-19 | 株式会社茉莉特斯 | Illumination apparatus and an endoscope with object illumination using the same |
| CN201123813Y (en) * | 2007-05-11 | 2008-10-01 | 重庆伟联科技有限公司 | Mammary gland diagnostic apparatus transmission probe |
| CN202184721U (en) * | 2011-05-27 | 2012-04-11 | 浙江大学 | Lymph gland and blood vessel upper conversion fluorescent imaging system |
| CN102578995A (en) * | 2011-12-22 | 2012-07-18 | 诊断有限公司 | Method for diagnosing organs of humans and animals and implementation device |
| US20140364743A1 (en) * | 2012-01-06 | 2014-12-11 | The Florida International University Board Of Trustees | Near-infrared (nir) optical scanner |
| CN204839584U (en) * | 2015-06-14 | 2015-12-09 | 金外淑 | Device is diagnose to skin venereal disease |
| CN108814562A (en) * | 2018-07-12 | 2018-11-16 | 孙际燕 | A kind of light wave inspection diagnostic device |
| CN109602392A (en) * | 2017-10-04 | 2019-04-12 | 株式会社岛津制作所 | Imaging device |
| CN111150417A (en) * | 2020-04-02 | 2020-05-15 | 深圳市纳诺艾医疗科技有限公司 | Tomosynthesis imaging equipment of secondary fluorescence and imaging method thereof |
-
2020
- 2020-12-17 CN CN202011495300.3A patent/CN112617753A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1749642A (en) * | 2004-09-13 | 2006-03-22 | 冠德光电科技股份有限公司 | External hanging lighting device capable of regulating angle |
| CN1759803A (en) * | 2004-10-12 | 2006-04-19 | 株式会社茉莉特斯 | Illumination apparatus and an endoscope with object illumination using the same |
| CN201123813Y (en) * | 2007-05-11 | 2008-10-01 | 重庆伟联科技有限公司 | Mammary gland diagnostic apparatus transmission probe |
| CN202184721U (en) * | 2011-05-27 | 2012-04-11 | 浙江大学 | Lymph gland and blood vessel upper conversion fluorescent imaging system |
| CN102578995A (en) * | 2011-12-22 | 2012-07-18 | 诊断有限公司 | Method for diagnosing organs of humans and animals and implementation device |
| US20140364743A1 (en) * | 2012-01-06 | 2014-12-11 | The Florida International University Board Of Trustees | Near-infrared (nir) optical scanner |
| CN204839584U (en) * | 2015-06-14 | 2015-12-09 | 金外淑 | Device is diagnose to skin venereal disease |
| CN109602392A (en) * | 2017-10-04 | 2019-04-12 | 株式会社岛津制作所 | Imaging device |
| CN108814562A (en) * | 2018-07-12 | 2018-11-16 | 孙际燕 | A kind of light wave inspection diagnostic device |
| CN111150417A (en) * | 2020-04-02 | 2020-05-15 | 深圳市纳诺艾医疗科技有限公司 | Tomosynthesis imaging equipment of secondary fluorescence and imaging method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US3638644A (en) | Illuminated surgical speculum | |
| WO2007112431B1 (en) | Synchronization of illumination source and sensor for improved visualization of subcutaneous structures | |
| US6748259B1 (en) | Optical imaging of induced signals in vivo under ambient light conditions | |
| CN105962891B (en) | A kind of contact excitation light source of fluorescence imaging detecting system | |
| WO2020199605A1 (en) | Parathyroid gland recognition device and system | |
| US7874698B2 (en) | Transillumination having orange color light | |
| US10244944B2 (en) | Vein transillumination device using orange and red light with a white exam light | |
| KR20160137893A (en) | Endoscope probe for sono-photo dynamic therapy | |
| JPH02143202A (en) | Optical radiator | |
| WO2002061405A2 (en) | Method and hand-held device for fluorescence detection | |
| CN104136075A (en) | A hand-held device for combined light and electrotherapy of a skin surface | |
| US20080306470A1 (en) | Optical screening device | |
| US10761015B1 (en) | Handheld hemoglobin detecting device | |
| CN112617753A (en) | Transmission-type fluorescence radiography equipment capable of detecting deep lymphatic vessels and lymph nodes | |
| CN102316790A (en) | Meconium identification apparatus and method in the amniotic fluid | |
| TW200505390A (en) | Portable instrument provided with an optical device for measuring a physiological quantity and means for transmitting and/or receiving data | |
| CN106510629A (en) | Confocal blood vessel imaging machine | |
| WO2018186560A1 (en) | Method and apparatus for controlling depth of penetration of light energy using ultrasound energy | |
| US8808177B2 (en) | Medical surgical device for treating coloproctological pathologies | |
| CN205759152U (en) | A kind of aciculiform optical dynamic therapy device | |
| CN114711727A (en) | Novel parathyroid gland detecting device | |
| US20200085316A1 (en) | Dual Optical Path Sensor Module | |
| CN210077839U (en) | Disposable side-lighting guiding device | |
| JP3194328U (en) | Luminaire having a diffusion part on a peripheral surface of a light guide part | |
| CN112546453B (en) | Luminous body component and device for treating male erectile dysfunction based on laser irradiation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Address after: Room 302, 3 / F, building B1, phase III, Changsha E center, No.18 Xiangtai Road, Liuyang economic and Technological Development Zone, Changsha City, Hunan Province, 410300 Applicant after: Micro Intelligent Technology (Hunan) Co.,Ltd. Address before: Room 302, 3 / F, building B1, phase III, Changsha E center, No.18 Xiangtai Road, Liuyang economic and Technological Development Zone, Changsha City, Hunan Province, 410300 Applicant before: Hunan Manik Medical Technology Co.,Ltd. |
|
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210409 |