CN112604605B

CN112604605B - Slow-dropping device for preparing antiviral drug HIV intermediate

Info

Publication number: CN112604605B
Application number: CN202011439595.2A
Authority: CN
Inventors: 翟洋洋; 杨兰萍; 倪永; 周德军; 张真真; 陈兴颖; 张庆岭; 张文奎; 王振辉; 牛超
Original assignee: Henan University of Technology
Current assignee: Henan University of Technology
Priority date: 2020-12-10
Filing date: 2020-12-10
Publication date: 2023-01-10
Anticipated expiration: 2040-12-10
Also published as: CN112604605A

Abstract

The invention discloses a dripping slowing device for preparing an antiviral drug HIV (human immunodeficiency Virus) intermediate, which comprises a limiting frame, wherein a dropper is clamped in the limiting frame, the bottom end of the limiting frame is fixedly connected with a fixed block, a reaction beaker is arranged at the top of the limiting frame, a first threaded rod is rotatably connected in the limiting frame and penetrates through the limiting frame, a screwing sleeve is fixedly sleeved at one end of the first threaded rod, which is positioned at the outer side of the limiting frame, a first permanent magnet is fixedly sleeved on the first threaded rod, a second permanent magnet is slidably connected on the inner side wall of the dropper through a reset spring, and a plurality of connecting rods are rotatably connected at the bottom of the second permanent magnet. According to the invention, the first permanent magnet and the second permanent magnet are arranged in the slow dripping device, so that the dripping speed of the dropper can be accurately adjusted, the error of preparation of the antiviral drug HIV intermediate is reduced, and the accuracy of the preparation process of the antiviral drug HIV intermediate is effectively improved.

Description

Slow-dropping device for preparing antiviral drug HIV intermediate

Technical Field

The invention relates to the technical field of medicine preparation, in particular to a slow dripping device for preparing an antiviral medicine HIV intermediate.

Background

HIV is a retrovirus, the reverse transcription process is a process of synthesizing proviral DNA by taking virus RNA as a template under the action of virus reverse transcriptase, the unique function of the virus reverse transcriptase in the life cycle of the virus enables the virus reverse transcriptase to become an important target for antiviral treatment, and a reverse transcriptase inhibitor can specifically act on the virus reverse transcriptase to inhibit the activity of the virus reverse transcriptase.

When making reverse transcriptase inhibitor abacavir midbody, when utilizing the burette to carry out the dropping liquid, the speed of unable accurate control dropping liquid, cause antiviral medicine HIV midbody preparation error to appear, can't satisfy the requirement of reverse transcriptase midbody preparation, and simultaneously, at the in-process of dropping liquid, the phenomenon that the burette often can appear rocking, lead to the instability of whole manufacture process, in manufacturing process, the phenomenon that the burette that is equipped with liquid emptys and the reflection equipment emptys appears easily, further the liquid medicine spills, lead to whole manufacture midbody process degree of difficulty to promote, for this reason, a slow dropping device is prepared to antiviral medicine HIV midbody.

Disclosure of Invention

The invention aims to solve the defect that a slow dripping device in the prior art cannot accurately control dripping speed, and provides the slow dripping device for an antiviral medicament HIV (human immunodeficiency virus) intermediate.

In order to achieve the purpose, the invention adopts the following technical scheme:

the utility model provides an antiviral medicine HIV intermediate system is with slowing a device that drips, includes spacing frame, the inside joint of spacing frame has the burette, the bottom fixedly connected with fixed block of spacing frame, the reaction beaker has been placed at the top of spacing frame, the inside of spacing frame is rotated and is connected with first threaded rod, first threaded rod runs through spacing frame, the one end rigid coupling that first threaded rod is located the spacing frame outside has twisted the cover, the rigid coupling has first permanent magnet on the first threaded rod, there is the second permanent magnet through reset spring sliding connection on the inside wall of burette, the bottom of second permanent magnet is rotated and is connected with a plurality of connecting rods, the side sliding connection of burette has a plurality of stoppers, the connecting rod is kept away from the second permanent magnet and is rotated with corresponding stopper and be connected, the stopper extends to the outside of burette through the intercommunication mouth, the stopper is located the one end fixedly connected with dead lever in the burette outside, the inside of spacing frame is equipped with a plurality of first gasbags, the bottom of spacing frame is equipped with the second gasbag, sliding connection has the slide bar on the inside wall of burette, the slide bar, the both ends difference fixedly connected with scraper blade of slide bar, the inside of slide bar is provided with strikes off the mechanism.

Preferably, strike off the mechanism include with second permanent magnet bottom fixed connection's second threaded rod, the screwed pipe has been cup jointed to the screw thread on the second threaded rod, two fixed plates of fixedly connected with on the inside wall of burette, two it is connected with the dwang to rotate on the fixed plate inside wall, fixed the cup jointing has cylindrical gear on the dwang, cylindrical gear's middle fixed cup joints has the stay cord, cylindrical gear's one end and slide bar fixed connection are kept away from to the stay cord.

Preferably, the threaded pipe is connected with the inner side wall of the dropper in a sliding mode, the cylindrical gear is meshed with the threaded pipe, and the scraper slides on the inner side wall of the dropper.

Preferably, the bottom of reaction beaker is equipped with the recess, fixed the cup jointing has the sponge on the fixed block, the sponge contact of fixed cup jointing on the inside wall of recess and the lateral wall of fixed block, the bottom of spacing frame is equipped with a plurality of spacing holes, and is a plurality of spacing hole is located the recess under, and is a plurality of spacing hole is located around the fixed block.

Preferably, the ends of the first permanent magnet and the second permanent magnet which are close to each other are opposite in magnetism, so that an attractive force is generated.

Preferably, the first air bags are communicated with the second air bags through communicating pipes respectively, the second air bags penetrate through the limiting holes to be in contact with the grooves in the bottoms of the reaction beakers, one ends, far away from the limiting blocks, of the fixing rods are fixedly connected with pushing blocks, and the pushing blocks are in contact with the first air bags through limiting openings.

Preferably, the side surface of the dropper is fixedly connected with a plurality of liquid containing boxes, the bottoms of the liquid containing boxes are in through connection with adjusting pipes, the bottoms of the adjusting pipes are provided with two convex blocks, the adjusting pipes are provided with second communicating holes, the tops of the limiting blocks are provided with two limiting grooves, the limiting blocks are provided with first communicating holes, and the convex blocks slide on the corresponding limiting grooves.

Preferably, the dropper is in contact with the inner side wall of the limiting frame through a plurality of elastic sheets, the screwing sleeve is made of rubber, and a feeding hole is formed in the top of the liquid containing box.

Compared with the prior art, the invention has the beneficial effects that:

1. according to the invention, the first permanent magnet and the second permanent magnet are arranged in the slow dripping device, so that the dripping speed of the dropper can be accurately adjusted, the error in preparation of an antiviral drug HIV intermediate is reduced, the accuracy in the preparation process of the antiviral drug HIV intermediate is effectively improved, meanwhile, the whole slow dripping device is arranged in a triangular prism shape, the stability in the whole dripping process can be enhanced, the phenomenon that the dropper is toppled to cause liquid medicine to spill is avoided, the stability in the preparation process of the intermediate is improved, the dropper can be buffered by arranging the elastic sheet on the dropper, the phenomenon that liquid in a liquid storage box on the side surface of the dropper flows out is effectively avoided, and the waste of resources is avoided.

2. Set up the fixed block through the bottom at buffer, can fix the reaction beaker, avoid the beaker to empty at the in-process of intermediate preparation, can effectually protect the reaction beaker, and simultaneously, can further strengthen the stability in the whole intermediate preparation process, when utilizing the burette to carry out the dropping liquid and adjusting, can further advance further buffering through first gasbag and second gasbag to the side of reaction beaker and fixed block, strengthen the stability between fixed block and the reaction beaker, thereby can effectually solve the unstable phenomenon of whole slow dripping device.

3. Set up the scraper blade in the inside of burette, can be at the in-process of dropping liquid, scrape the liquid medicine on the burette inside wall, avoid the liquid medicine to remain on the inside wall of burette, influence the result of use of burette, simultaneously, utilize the scraper blade, can strike off the inside wall of burette when clearance burette, promote the clear clean efficiency of burette.

4. Through the setting of spacing frame, can solve traditional dropping liquid in-process, need the manual work to hold between the fingers the drawback that the burette operated, reduce the degree of difficulty nature of operation in the intermediate manufacture process, whole operation process is simple, the implementation of being convenient for.

Drawings

FIG. 1 is a schematic structural diagram of a slow-dropping device for an antiviral drug HIV intermediate preparation provided by the present invention;

FIG. 2 is an enlarged view of FIG. 1 at A;

FIG. 3 is an enlarged view at B of FIG. 1;

FIG. 4 is an enlarged view at C of FIG. 2;

FIG. 5 is a left side view of the threaded tube and cylindrical gear of FIG. 1;

FIG. 6 is a perspective view of the stop block of FIG. 1;

FIG. 7 is a perspective view of the adjustment tube of FIG. 1;

fig. 8 is a schematic structural view of the cylindrical gear in fig. 1.

In the figure: 1 limit frame, 2 first threaded rod, 3 twist sleeve, 4 first permanent magnet, 5 reaction beaker, 6 first gasbag, 7 second gasbag, 8 burette, 9 fixed rod, 10 pushing block, 11 elastic sheet, 12 liquid containing box, 13 second permanent magnet, 14 connecting rod, 15 limit block, 16 adjusting tube, 17 slide bar, 18 scraper, 19 fixed block, 20 limit hole, 21 second threaded rod, 22 threaded tube, 23 cylindrical gear, 24 fixed plate, 25 rotating rod, 26 limit groove, 27 first connecting hole, 28 convex block, 29 second connecting hole, 30 limit opening.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.

In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", and the like, are used in the orientations and positional relationships indicated in the drawings, which are based on the orientations and positional relationships indicated in the drawings, and are used for convenience of description and simplicity of description, but do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, are not to be construed as limiting the present invention.

Referring to fig. 1-8, a sustained-drop device for preparing an antiviral drug HIV intermediate, comprising a limiting frame 1, it is to be noted that the whole limiting frame 1 is in a triangular prism shape, the limiting frame 1 can support the whole sustained-drop device to maintain the stability of the whole device, a dropper 8 is clamped inside the limiting frame 1, a liquid medicine is added into a reaction beaker 5 through the dropper 8, a fixed block 19 is fixedly connected to the bottom end of the limiting frame 1, the reaction beaker 5 is placed on the top of the limiting frame 1, a first threaded rod 2 is rotatably connected inside the limiting frame 1, the first threaded rod 2 penetrates through the limiting frame 1, a screwing sleeve 3 is fixedly sleeved on one end of the first threaded rod 2, which is located outside the limiting frame 1, a first permanent magnet 4 is fixedly sleeved on the first threaded rod 2, a second permanent magnet 13 is slidably connected on the inner side wall of the dropper 8 through a reset spring, a plurality of connecting rods 14 are rotatably connected to the bottom of the second permanent magnet 13, the side surface of the dropper 8 is connected with a plurality of limiting blocks 15 in a sliding manner, it should be noted that the air tightness of the joint of the limiting block 15 and the dropper 8 is good, the connecting rod 14 is far away from the second permanent magnet 13 and is connected with the corresponding limiting block 15 in a rotating manner, the limiting block 15 extends to the outer side of the dropper 8 through a communicating port, one end of the limiting block 15, which is positioned at the outer side of the dropper 8, is fixedly connected with a fixing rod 9, the inside of the limiting frame 1 is provided with a plurality of first air bags 6, the bottom end of the limiting frame 1 is provided with a second air bag 7, the inner side wall of the dropper 8 is connected with a sliding rod 17 in a sliding manner, two ends of the sliding rod 17 are respectively and fixedly connected with scraping plates 18, the bottom of the reaction beaker 5 is provided with a groove, the fixing block 19 is fixedly sleeved with a sponge, the inner side wall of the groove is in contact with the sponge fixedly sleeved on the outer side wall of the fixing block 19, the sponge can protect the reaction beaker 5 and further cushion the reaction beaker 5, the bottom of limiting frame 1 is equipped with a plurality of spacing holes 20, a plurality of spacing holes 20 are located under the recess, a plurality of spacing holes 20 are located around fixed block 19, a plurality of first airbags 6 communicate with second airbags 7 through communicating pipe respectively, second airbags 7 pass spacing holes 20 and contact with the recess of reaction beaker 5 bottom, dead lever 9 keeps away from one end fixedly connected with of stopper 15 and promotes piece 10, promote piece 10 and contact with first airbags 6 through spacing mouth 30, through set up fixed block 19 in buffer's bottom, can fix reaction beaker 5, avoid reaction beaker 5 to topple over at the in-process of intermediate preparation, can effectually protect reaction beaker 5, and simultaneously, can further strengthen the stability in the whole intermediate preparation process, when utilizing burette 8 to carry out the dropping liquid regulation, can further advance further to cushion reaction beaker 5 and the side of fixed block 19 through first airbags 6 and second airbags 7, strengthen the stability between 19 and the reaction beaker 5, thereby can effectually solve the unstable phenomenon of whole slow dripping device.

The inside of burette 8 is provided with scrapes the mechanism, scrape the mechanism and include the second threaded rod 21 with second permanent magnet 13 bottom fixed connection, threaded pipe 22 has been cup jointed to the screw thread on second threaded rod 21, two fixed plates 24 of fixedly connected with on the inside wall of burette 8, it has dwang 25 to rotate on two fixed plate 24 inside walls, dwang 25 is last to fix the cover and has been cup jointed cylindrical gear 23, the fixed stay cord that has cup jointed in the middle of cylindrical gear 23, the one end and slide bar 17 fixed connection that cylindrical gear 23 was kept away from to the stay cord, screwed pipe 22 and burette 8's inside wall sliding connection, cylindrical gear 23 and screwed pipe 22 mesh, scraper 18 slides on burette 8's inside wall, set up scraper 18 in burette 8's inside, can be at the in-process of dropping liquid, scrape the liquid medicine on burette 8 inside wall, avoid the liquid medicine to remain on burette's inside wall, influence the result of use of burette, simultaneously, utilize scraper 18, can be when clearing up the burette, the inside wall of burette 8 is scraped, the clean cleanness efficiency of burette is promoted.

The magnetism of the end of the first permanent magnet 4 close to the second permanent magnet 13 is opposite, attractive force is generated, a plurality of liquid containing boxes 12 are fixedly connected to the side face of the dropper 8, the bottom of the liquid containing boxes 12 is connected with the adjusting pipe 16 in a penetrating mode, two convex blocks 28 are arranged at the bottom of the adjusting pipe 16, a second communicating hole 29 is formed in the adjusting pipe 16, two limiting grooves 26 are formed in the top of the limiting block 15, first communicating holes 27 are formed in the limiting block 15, the convex blocks 28 slide on the corresponding limiting grooves 26, the dropper 8 is in contact with the inner side wall of the limiting frame 1 through the elastic sheets 11, the twisting sleeve 3 is made of rubber, hands can be protected, the phenomenon that the hands are abraded when the first threaded rod 2 is twisted by hands is avoided, meanwhile, friction between the hands and the first threaded rod 2 can be further increased, the phenomenon that liquid dropping errors are caused by hand sliding in the twisting process is reduced, a feed inlet is formed in the top of the liquid containing boxes 12, and liquid is filled through the feed inlet.

The invention can be illustrated by the following operating modes:

firstly, the liquid medicine for preparing the antiviral drug HIV reverse transcriptase intermediate is added into the liquid filling box 12 through the feeding hole in the liquid filling box 12, the reaction beaker 5 is placed on the fixing block 19 at the bottom of the limiting frame 1 through the groove at the bottom of the reaction beaker 5, a hand is placed on the screwing sleeve 3 to screw the first threaded rod 2, and the first permanent magnet 4 is fixedly sleeved on the first threaded rod 2, so the first permanent magnet 4 can be further driven to rotate along with the rotation of the first threaded rod 2, and the magnetism of the end, close to the first permanent magnet 4 and the second permanent magnet 13, of the first permanent magnet 4 is opposite to that of the end, close to the second permanent magnet 13, so the magnetism of the end, close to the first permanent magnet 4 and the second permanent magnet 13, is gradually the same along with the rotation of the first threaded rod 2, repulsion force is generated, and the generated repulsion force pushes the second permanent magnet 3 to slide downwards.

Because the limiting block 15 is connected with the inner side wall of the dropper 8 in a sliding manner, the bottom of the second permanent magnet 13 is connected with the limiting block 15 through the connecting rod 14, and two ends of the connecting rod 14 are respectively connected with the bottom end of the second permanent magnet 13 and the limiting block 15 in a rotating manner, therefore, in the process that the second permanent magnet 13 moves downwards, the limiting block 15 is driven to move towards two sides, so that the positions of the first communication hole 27 on the limiting block 15 and the second communication hole 29 on the adjusting pipe 16 can be adjusted, the speed of liquid dropping is adjusted by controlling the positions of the first communication hole 27 on the positioning block 15 and the second communication hole 29 on the adjusting pipe 16, in the moving process of the limiting block 15, the pushing block 10 can be further driven to push the first air bag 6 through the limiting opening 30, and the first air bag 6 is communicated with the second air bag 7 through the communicating pipe, therefore, the second air bag 7 can be further promoted to be in contact with the groove at the bottom of the reaction beaker 5 through the limiting hole 20.

In the process that the second permanent magnet 13 moves downwards, the second threaded rod 21 fixedly connected with the bottom of the second permanent magnet 13 is in threaded sleeve connection with the threaded pipe 22, therefore, the threaded pipe 22 is driven to rotate along with the second threaded rod 21 moving downwards of the second permanent magnet 13, and the threaded pipe 22 is meshed with the cylindrical gear 23, therefore, the cylindrical gear 23 can be further driven to rotate by the rotation of the threaded pipe 22, and the sliding rod 17 is fixedly connected with the pull rope between the sliding rod 17 and the cylindrical gear 23 because the sliding rod 17 is in sliding connection with the inner side wall of the dropper 8, so that the sliding rod 17 is driven to move upwards along with the rotation of the cylindrical gear 23, so that the scraper 18 can be further driven to move upwards along the inner side wall of the dropper 8, similarly, when the first threaded rod 2 is rotated reversely, the second permanent magnet 13 moves upwards to drive the plurality of limit blocks 15 to contract into the dropper 8, the sliding rod 17 moves downwards until the first communication hole 27 on the limit block 15 does not correspond to the second communication hole 29 on the adjusting pipe 16 any more, the dropping is completed, and when the dropper 8 needs to be cleaned, the liquid medicine in the liquid tank 12 needs to be replaced by the cleaning operation, and the cleaning operation can be repeated.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered as the technical solutions and the inventive concepts of the present invention within the technical scope of the present invention.

Claims

1. The utility model provides an antiviral medicine HIV midbody system is with slowing a device that drips, includes spacing frame (1), its characterized in that, the inside joint of spacing frame (1) has burette (8), the bottom fixedly connected with fixed block (19) of spacing frame (1), reaction beaker (5) are placed at the top of spacing frame (1), the internal rotation of spacing frame (1) is connected with first threaded rod (2), spacing frame (1) is run through in first threaded rod (2), first threaded rod (2) are located the fixed cover that twists of the one end in spacing frame (1) outside and have been cup jointed (3), fixed cover has been cup jointed first permanent magnet (4) on first threaded rod (2), there is second permanent magnet (13) through reset spring sliding connection on the inside wall of burette (8), the bottom of second permanent magnet (13) is rotated and is connected with a plurality of connecting rods (14), the side sliding connection of burette (8) has a plurality of stopper (15), second stopper (13) is kept away from in the rotation with corresponding stopper (15) in connecting rod (14), extend to the outside of permanent magnet stopper (8) through the opening, burette (15) the fixed connection of the one end of burette (8) is located a plurality of inner side of the burette (6), burette (6) of the fixed connection of burette (6), the bottom of spacing frame (1) is equipped with second gasbag (7), sliding connection has slide bar (17) on the inside wall of burette (8), the both ends difference fixedly connected with scraper blade (18) of slide bar (17), the inside of burette (8) is provided with strikes off the mechanism, the bottom of reaction beaker (5) is equipped with the recess, fixed cover has been connect with the sponge on fixed block (19), the sponge contact of fixed cup joint on the inside wall of recess and the lateral wall of fixed block (19), the bottom of spacing frame (1) is equipped with a plurality of spacing holes (20), and is a plurality of spacing hole (20) are located the recess under, and are a plurality of spacing hole (20) are located around fixed block (19), the one end magnetism that first permanent magnet (4) and second permanent magnet (13) are close to each other is opposite, produces the gravitation, and a plurality of first gasbag (6) communicate with second gasbag (7) through communicating pipe respectively, second gasbag (7) pass through spacing hole (20) and the recess contact of reaction beaker (5) bottom, the one end magnetism that fixed rod (9) was kept away from fixed, the fixed rod (15) is connected with the side of thrust box (10), thrust box (10) is connected with a plurality of regulating block (12) and thrust box (10) are connected with spacing liquid packing box (12), the bottom of the adjusting pipe (16) is provided with two convex blocks (28), the adjusting pipe (16) is provided with a second communicating hole (29), the top of the limiting block (15) is provided with two limiting grooves (26), the limiting block (15) is provided with a first communicating hole (27), and the convex blocks (28) slide on the corresponding limiting grooves (26).

2. The slow dripping device for the intermediate preparation of the antiviral drug HIV according to claim 1, wherein the scraping mechanism comprises a second threaded rod (21) fixedly connected with the bottom of the second permanent magnet (13), a threaded pipe (22) is screwed on the second threaded rod (21), two fixing plates (24) are fixedly connected with the inner side wall of the dropper (8), a rotating rod (25) is rotatably connected with the inner side wall of the two fixing plates (24), a cylindrical gear (23) is fixedly sleeved on the rotating rod (25), a pull rope is fixedly sleeved in the middle of the cylindrical gear (23), and one end of the pull rope, which is far away from the cylindrical gear (23), is fixedly connected with the sliding rod (17).

3. The anti-viral drug HIV intermediate preparation slow-dripping device as claimed in claim 2, wherein the threaded tube (22) is slidably connected with the inner side wall of the dripping tube (8), the cylindrical gear (23) is engaged with the threaded tube (22), and the scraper (18) slides on the inner side wall of the dripping tube (8).

4. The slow dripping device for the intermediate preparation of the antiviral drug HIV according to claim 1, wherein the dripping tube (8) is in contact with the inner side wall of the limiting frame (1) through a plurality of elastic pieces (11), the screwing sleeve (3) is made of rubber, and the top of the liquid containing box (12) is provided with a feeding hole.