CN112604048B - Special pipeline for total-liver type bioartificial liver support system - Google Patents
Special pipeline for total-liver type bioartificial liver support system Download PDFInfo
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- CN112604048B CN112604048B CN202011407993.6A CN202011407993A CN112604048B CN 112604048 B CN112604048 B CN 112604048B CN 202011407993 A CN202011407993 A CN 202011407993A CN 112604048 B CN112604048 B CN 112604048B
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- 210000004185 liver Anatomy 0.000 title claims abstract description 158
- 210000004369 blood Anatomy 0.000 claims abstract description 118
- 239000008280 blood Substances 0.000 claims abstract description 118
- 230000002440 hepatic effect Effects 0.000 claims abstract description 55
- 230000010412 perfusion Effects 0.000 claims abstract description 53
- 238000000926 separation method Methods 0.000 claims abstract description 43
- 230000004087 circulation Effects 0.000 claims abstract description 33
- 210000000601 blood cell Anatomy 0.000 claims description 10
- 230000002572 peristaltic effect Effects 0.000 claims description 7
- 210000003462 vein Anatomy 0.000 claims description 7
- 210000000941 bile Anatomy 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 238000011084 recovery Methods 0.000 claims description 4
- 238000009530 blood pressure measurement Methods 0.000 claims description 2
- 210000001503 joint Anatomy 0.000 abstract 1
- 210000002381 plasma Anatomy 0.000 description 85
- 238000010586 diagram Methods 0.000 description 8
- 239000002002 slurry Substances 0.000 description 7
- 230000008859 change Effects 0.000 description 5
- 239000007788 liquid Substances 0.000 description 4
- 210000001367 artery Anatomy 0.000 description 3
- 210000003459 common hepatic duct Anatomy 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000006978 adaptation Effects 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000005034 decoration Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 206010019663 Hepatic failure Diseases 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 208000007903 liver failure Diseases 0.000 description 1
- 231100000835 liver failure Toxicity 0.000 description 1
- 238000010309 melting process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000002616 plasmapheresis Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
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Abstract
The application provides a special pipeline for a total-liver bioartificial liver system, which comprises a plasma separating pipeline, a blood storage tank, a blood guide pipeline of the blood storage tank, a hepatic anterior pipeline, a hepatic posterior pipeline and a total-liver perfusion device; the plasma separation pipeline comprises a plasma separation conduit and a plasma separation pump, and the plasma separation conduit is connected with the blood storage tank to input receptor plasma; the blood storage tank blood-leading pipeline comprises a blood-leading conduit and a blood-leading pump, the hepatic anterior pipeline comprises a hepatic anterior conduit, the hepatic posterior pipeline comprises a hepatic posterior conduit, the blood-leading conduit, the hepatic anterior conduit and the hepatic posterior conduit are sequentially connected in the direction from the output end to the input end of the blood storage tank, and the total liver perfusion device is arranged between the hepatic anterior conduit and the hepatic posterior conduit; the blood storage tank blood leading pipeline, the pre-hepatic pipeline, the post-hepatic pipeline and the total liver perfusion device form an extracorporeal liver perfusion circulation, and the plasma separation pipeline and the extracorporeal liver perfusion circulation are connected in parallel through the blood storage tank. The special pipeline provided by the invention is suitable for a total-liver bioartificial liver system, can realize butt joint of various devices in the system, and is convenient to install.
Description
Technical Field
The application relates to the field of medical equipment, in particular to a pipeline special for a total-liver bioartificial liver support system.
Background
The bioartificial liver support system is a hot spot of current research as a 'bridge treatment' method during the waiting period of liver failure for liver source or liver self-regeneration, and the current artificial liver support system mainly comprises a biotype artificial liver support system, a non-biotype artificial liver support system and a combined type biotype artificial liver support system, wherein the biotype artificial liver is divided into two types of hepatocyte type and whole liver type according to the difference of reactors. Based on the idea that the best artificial liver support is the liver, the whole liver type bioreactor has richer number of functional cells, optimal three-dimensional space conformation of the cells and better cost effect, and the clinical application has been successfully transited to liver transplantation or autologous liver regeneration. However, the existing total-liver type artificial liver system has the problems of redundant system, poor liver perfusion and the like, and further popularization and application of the system are limited.
In addition, the conventional total liver type bioartificial liver system does not have a matched pipeline, so that the pipeline is usually required to be disassembled and butted again according to actual requirements in order to realize the mutual matching of different treatment modes, and the conventional pipeline is not suitable for the total liver type bioartificial liver, so that the problems of inconvenient assembly and disassembly and complex structure of pipeline connection exist.
Disclosure of Invention
The purpose of this application aims at providing one kind and is adapted to the biological artificial liver system of whole liver type, simple structure, simple to operate's the special pipeline of biological artificial liver system of whole liver type.
In order to achieve the above object, the present application provides the following technical solutions:
a special pipeline for a total liver type bioartificial liver system comprises a plasma separating pipeline, a blood storage tank, a blood leading pipeline of the blood storage tank, a hepatic anterior pipeline, a hepatic posterior pipeline and a total liver perfusion device;
the plasma separation pipeline comprises a plasma separation guide pipe and a plasma separation pump, and the plasma separation guide pipe is connected with the input end of the blood storage tank to input receptor plasma;
the blood storage tank blood-leading pipeline comprises a blood-leading conduit and a blood-leading pump, the hepatic anterior pipeline comprises a hepatic anterior conduit, the hepatic posterior pipeline comprises a hepatic posterior conduit, the blood-leading conduit, the hepatic anterior conduit and the hepatic posterior conduit are sequentially connected in a direction from the output end to the input end of the blood storage tank, and the total liver perfusion device is arranged between the hepatic anterior conduit and the hepatic posterior conduit;
the whole liver perfusion device is used for purifying receptor plasma, and the blood storage tank draws blood pipeline, preceding pipeline of liver, pipeline and whole liver perfusion device behind the liver and constitutes external liver perfusion circulation, divide the thick liquid pipeline and external liver perfusion circulation passes through blood storage tank parallel connection.
Further setting: a peristaltic pump is arranged between the blood guide catheter and the hepatic anterior catheter.
Further setting: the plasma separation pipeline is connected with a first plasma separator, and the first plasma separator is provided with a first blood inlet, a first plasma outlet and a first blood cell outlet;
the plasma separating pipeline is connected with the first plasma outlet, the first blood inlet is connected with an arterial pipeline, the blood cell outlet of the first plasma separator is connected with a venous pipeline, and the plasma separating pipeline, the arterial pipeline and the venous pipeline form plasma separating circulation.
Further setting: the arterial pipeline comprises an arterial catheter connected with a deep blood-drawing venous catheter preset in a receptor, a blood suction pump and an arterial kettle are arranged on the arterial catheter, and the arterial kettle is at least provided with three joints;
the venous line comprises a venous catheter connected with a receptor vein, a venous pot is arranged on the venous catheter, and the venous pot is at least provided with four connectors.
Further setting: and the arterial pipeline and the venous pipeline are connected with a medicine input device.
Further setting: the plasma separator also comprises a second plasma separator, a circulating pipeline and a plasma return pipeline;
the second plasma separator is provided with a second blood inlet, a second plasma outlet and a second blood cell outlet, and the second blood inlet is connected with the output end of the blood storage tank;
the circulating pipeline comprises a blood guide pipe and a circulating pipe, the second plasma separator is arranged between the blood guide pipe and the circulating pipe, the blood guide pipe is connected with the output end of the blood storage tank, a blood guide pump is arranged on the blood guide pipe, and the circulating pipe is connected with the input end of the blood storage tank;
the plasma return pipeline comprises a plasma return conduit and a plasma return pump, one end of the plasma return conduit is connected with the second plasma outlet, and the other end of the plasma return conduit is connected with the venous kettle of the venous pipeline.
Further setting: the output end of the blood storage tank is connected with the blood guide pipe of the blood guide pipeline of the blood storage tank and the blood guide pipe of the circulating pipeline through a three-way valve.
Further setting: still include a plurality of pressure measurement, locate respectively on arteria kettle, venous pot, first plasma separator, second plasma separator, preceding pipe of liver and the pipe behind the liver.
Further setting: the whole liver perfusion device comprises a whole liver and a perfusion cabin body, the whole liver adopts an animal liver, and the whole liver perfusion device is connected with a bile recovery device.
Further setting: the ports of the special pipeline are realized in the following forms:
the male joint consists of a tubular joint, the front end of the tubular joint is provided with a connecting part, the outer side wall of the tubular joint is provided with an armrest part, and the tubular joint can coaxially rotate relative to a pipe body connected with the tubular joint;
the female joint comprises a bearing part matched with the connecting part and is fixedly connected to the port of the pipeline.
Compared with the prior art, the scheme of the application has the following advantages:
1. the utility model provides a biological artificial liver system's of whole liver type special pipeline adaptation whole liver type of whole liver type biological artificial liver system use, and this special pipeline can realize being connected with dismantling of whole liver perfusion device, then can change the alternate use in order to realize multiple treatment template to whole liver perfusion device, realize reaching the treatment purpose of different modes in a biological artificial liver system, thereby alleviate patient's economic burden, dismantle it when need not to use whole liver perfusion device again simultaneously, and deposit whole liver perfusion device properly, in order to prolong whole liver perfusion device's live time.
2. In the special pipeline of the total-liver type bioartificial liver system, the joints on each pipeline are convenient to connect and easy to disassemble and assemble, and the special pipeline assembling efficiency is favorably improved.
Additional aspects and advantages of the present application will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the present application.
Drawings
The foregoing and/or additional aspects and advantages of the present application will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:
FIG. 1 is a schematic structural diagram of a dedicated pipeline of a total liver type bioartificial liver system of the present application;
FIG. 2 is a schematic diagram of an arterial line in a dedicated line for a total liver bioartificial liver system of the present application;
FIG. 3 is a schematic diagram of a venous line and a plasma return line in a dedicated line for a total liver type bioartificial liver system of the present application;
FIG. 4 is a schematic diagram of a plasma separation pipeline in a dedicated pipeline of a total liver type bioartificial liver system of the present application;
FIG. 5 is a schematic diagram of a blood drawing line of a blood storage tank in a dedicated line of a total liver type bioartificial liver system of the present application;
FIG. 6 is a schematic diagram of a pre-hepatic line in a dedicated line for a total liver type bioartificial liver system of the present application;
FIG. 7 is a schematic diagram of a posterior hepatic line of the dedicated line for a total hepatic bioartificial liver system of the present application;
fig. 8 is a schematic diagram of a circulation conduit in a dedicated pipeline of a total liver bioartificial liver system of the present application.
In the figure, 11, the arterial line; 111. an arterial catheter; 1111. a blood pump installation position; 112. a puncture head; 113. the arteria cruris; 114. a cross joint; 115. a blood pump is pumped; 12. a venous line; 121. an intravenous catheter; 122. a venous pot; 13. a slurry separation pipeline; 131. a slurry separation conduit; 1311. a slurry distributing pump mounting position; 132. a slurry distributing pump; 14. a first plasma separator; 21. a blood storage tank blood leading pipeline; 211. a blood-drawing catheter; 2111. a peristaltic pump mounting position; 212. a peristaltic pump; 22. the anterior hepatic line; 221. a hepatic front conduit; 23. the posthepatic line; 231. a posthepatic duct; 24. a whole liver perfusion device; 241. a bile recovery device; 25. an oxygenator; 31. a circulation line; 311. a circulation conduit; 312. a blood drainage pump; 32. a slurry return pipeline; 321. a slurry return conduit; 3211. a pulp return pump mounting position; 322. a slurry return pump; 33. a second plasma separator; 4. a blood storage tank; 51. a male connector; 52. a female joint; 53. capping; 61. a conduit; 62. a 23mm HMEF filter; 7. a pipe clamp.
Detailed Description
Reference will now be made in detail to embodiments of the present application, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are exemplary only for the purpose of explaining the present application and are not to be construed as limiting the present application.
Referring to fig. 1 to 8, in order to adapt to the use of the total liver type bioartificial liver system, the present application provides a dedicated pipeline for the total liver type bioartificial liver system, which comprises a pipeline for three cycles of plasma separation cycle, extracorporeal liver perfusion cycle, and plasma separation return cycle: the blood collection device comprises an arterial pipeline 11, a venous pipeline 12, a plasma separation pipeline 13, a blood storage tank blood leading pipeline 21, a hepatic anterior pipeline 22, a hepatic posterior pipeline 23, a circulation pipeline 31 and a plasma return pipeline 32. Wherein, the plasma separation circulation comprises an arterial pipeline 11, a venous pipeline 12 and a plasma separation pipeline 13; the extracorporeal liver perfusion circulation comprises a blood storage tank blood leading pipeline 21, a pre-hepatic pipeline 22 and a post-hepatic pipeline 23; the plasma separation and return circulation comprises a circulation pipeline 31 and a plasma return pipeline 32, and three liquid circulations of the plasma separation circulation, the extracorporeal liver perfusion circulation and the plasma separation and return circulation are connected in parallel.
It should be noted that, the connection between the various pipeline ports of the present application is realized in a form of the male connector 51 and the female connector 52 being matched with each other. The male joint 51 consists of a tubular joint, the front end of the tubular joint is provided with a connecting part, the outer side wall of the tubular joint is provided with an armrest part, and the tubular joint can coaxially rotate relative to a pipe body connected with the tubular joint; the female connector 52 includes a receiving portion matching the connecting portion and is fixedly connected to a port of the corresponding pipe.
The utility model provides a biological artificial liver system of total liver type is through setting up blood storage tank 4, makes plasma separation circulation, external liver fill circulation and plasma separation feedback circulation respectively with blood storage tank 4 is connected in order to constitute parallelly connected three relatively independent circulation line 31 to improve biological artificial liver system's flow greatly, improved biological artificial liver system's work efficiency.
The artery pipeline 11 is as the inlet pipeline of special pipeline, the outlet pipeline of special pipeline is regarded as to the vein pipeline 12, artery pipeline 11 with the vein pipeline 12 is connected through first plasma separator 14, and first plasma separator 14 includes first blood entry, first plasma export and first blood cell export, artery pipeline 11 and first blood entry linkage, vein pipeline 12 and first plasma exit linkage, divide the thick liquid pipeline 13 with first plasma exit linkage and be connected to the input of blood storage tank 4.
Specifically, referring to fig. 2, the arterial line 11 includes an arterial tube 111 connected to a deep venous catheter for drawing blood preset in a recipient, a puncture head 112 is disposed at an end of the arterial tube 111, a blood pump 115 and an arterial pot 113 are disposed on the arterial tube 111, correspondingly, a blood pump mounting position 1111 for mounting the blood pump 115 is disposed on the arterial tube 111, the arterial pot 113 has three interface connectors, one of the interface connectors is used for connecting a pressure sensor, the connector is connected to a 600mm long catheter 61, a 23mm hmef filter 62 and a female lock taper female connector 52 are disposed at an end of the catheter 61, and a pipe clamp 7 is disposed on the catheter 61 to control a flow rate of the catheter 61; the remaining two interface connectors are used to connect the arterial tube 111, and the arterial kettle 113 is provided with a female lock cone connector 52 on the arterial tube 111 to which the connector near the first plasma separator 14 is connected.
In addition, the arterial line 111 is provided with a cross connector 114 for connecting a drug input device, which in a possible embodiment may be selected from a quantitative or a timing device such as a syringe for injecting a drug into the blood input line. And one of the other two connectors of the cross connector 114 except for the other two connectors connected with the arterial catheter 111 is provided with a dosing plug, the other connector can be provided with a conical female connector 52, and a cap 53 can be arranged on the conical female connector 52 to play a role of dust prevention when the conical female connector 52 is not used.
Referring to fig. 3, the venous line 12 includes a venous catheter 121 connected to a recipient vein, a venous pot 122 having four connectors is disposed on the venous catheter 121, two connectors are used for connecting the venous line, a female locking conical female connector 52 is disposed at an end of the venous catheter 121 of the venous pot 122 and the first plasma separator 14, and a male locking conical male connector 51 is disposed at an end of the venous catheter 121 connected to the recipient vein, and is connected to the puncture head 112 through the male locking conical male connector 51. In addition, one of the two remaining connections serves for the connection of a pressure sensor, while the other connection serves for the connection to the return line of the plasmapheresis return circuit.
In addition, a drug input device is connected to the venous pot 122 and the venous line 121 of the first plasma separator 14.
Referring to fig. 4, the plasma separation pipeline 13 includes a plasma separation conduit 131 and a plasma separation pump 132, a plasma separation pump mounting position 1311 is disposed on the plasma separation conduit 131, a tapered male joint 51 is disposed at an end portion of the plasma separation conduit 131 connected to the first plasma separator 14, a tapered male joint 51 is disposed at an end portion of the plasma separation conduit 131 connected to the blood storage tank 4, and a cap 53 with a length of 10mm is disposed at the tapered male joint 51, so as to serve as a connector joint dust cap at a connection portion of the plasma separation pipeline 13 and the blood storage tank 4.
Blood of receptor flows into blood storage tank 4 through the plasma separation circulation that the whole liver type bioartificial liver system of this application separates the plasma that comes out, and with the external liver oxygen carrier that prestores in the blood storage tank 4 mixes, and blood after the mixture can enter into purify in the external liver perfusion circulation.
The blood storage tank blood leading pipeline 21, the hepatic anterior pipeline 22 and the hepatic posterior pipeline 23 of the extracorporeal liver perfusion circulation are sequentially connected in the direction from the output end of the blood storage tank 4 to the input end thereof.
Specifically, referring to fig. 5, 6 and 7, the blood storage tank blood guiding pipeline 21 includes a blood guiding conduit 211 and a peristaltic pump 212, correspondingly, a peristaltic pump installation position 2111 is disposed on the blood guiding conduit 211, the anterior hepatic conduit 22 includes a anterior hepatic conduit 221, the posterior hepatic conduit 23 includes a posterior hepatic conduit 231, an oxygenator 25 is disposed between the blood guiding conduit 211 and the anterior hepatic conduit 22, a total hepatic perfusion device 24 for purifying mixed plasma and extracorporeal liver oxygen carriers is connected between the anterior hepatic conduit 22 and the posterior hepatic conduit 23, a conical male joint 51 is disposed at an end of the anterior hepatic conduit 22 connected to the total hepatic perfusion device 24, and a thread melting process is performed at the conical male joint 51.
Simultaneously, behind the liver pipeline 23 with the tip that whole liver perfusion device 24 is connected also sets up circular cone male joint 51, then behind liver pipeline 221 and the liver pipe 231 all adopt circular cone male joint 51 to realize being connected with dismantling of whole liver perfusion device 24, and simple to operate is swift to in actual clinic, can change the pipeline as required or change whole liver perfusion device 24, improve the rate of utilization of this application whole liver type biological artificial liver system.
The whole liver perfusion device 24 includes a whole liver and a perfusion chamber for accommodating the whole liver, and in the present system, the whole liver is derived from an animal liver, and specifically, a fresh pig whole liver can be used. Meanwhile, the whole liver is connected with a bile recovery device 241 to recover bile for parameter index detection.
In addition, the pre-hepatic duct 221 and the post-hepatic duct 231 can be connected to a pressure sensor through a three-way joint to monitor the pressure change of the pre-hepatic duct 22 and the post-hepatic duct 23 in real time, so as to adjust the perfusion pressure, flow and flow rate of the extracorporeal liver perfusion cycle through the peristaltic pump 212, thereby ensuring that the whole liver perfusion apparatus 24 is in the optimal internal and external environment and has good alternative functions.
Plasma purified by the extracorporeal liver perfusion cycle may be separated by the plasma separation return cycle and returned to the recipient. Referring to fig. 1 and 8, the circulation pipeline 31 includes a blood guiding conduit and a circulation conduit 311, a second plasma separator 33 is disposed between the blood guiding conduit and the circulation conduit 311, the second plasma separator 33 includes a second blood inlet, a second plasma outlet and a second blood cell outlet, the blood guiding conduit 211 is connected between the output end of the blood storage tank 4 and the second blood inlet, and a blood guiding pump 312 is disposed on the blood guiding conduit 211.
It should be noted that the structure of the blood guiding tube 211 is the same as that of the blood guiding tube 211 of the extracorporeal liver perfusion cycle, and the output end of the blood storage tank 4 is connected with the blood guiding tube 211 of the extracorporeal liver perfusion cycle and the three tubes 61 of the blood guiding tube 211 of the plasma separation and return transfusion cycle through three-way valves (not shown).
The circulation pipe 311 is connected to the second blood cell outlet and the input end of the blood storage tank 4, the end of the circulation pipe 311 connected to the blood storage tank 4 is provided with a conical male connector 51, the connection part of the circulation pipe 311 and the second blood cell outlet is provided with a conical female connector 52, and the second blood plasma outlet is connected to the return pipeline.
Referring to fig. 1 and fig. 2, the plasma return pipe 32 includes a plasma return pipe 321 and a plasma return pump 322, and correspondingly, a mounting position 3211 of the plasma return pump is disposed on the plasma return pipe 321, one end of the plasma return pipe 321 is connected to the second plasma outlet, the other end of the plasma return pipe is connected to the venous kettle 122 on the venous pipe 12, and a conical male connector 51 is disposed at an end of the plasma return pipe 321 connected to the second plasma outlet.
In addition, it should be emphasized that the dedicated line for a total liver bioartificial liver system of the present application further includes a plurality of pressure detection devices respectively disposed on the arterial pot 113, the venous pot 122, the first plasma separator 14, the second plasma separator 33, the pre-hepatic duct 221, and the post-hepatic duct 231 to monitor the flow rate of the liquid in the dedicated line in real time.
The utility model provides a biological artificial liver system's of whole liver type special pipeline adaptation whole liver type of whole liver type biological artificial liver system use, and this special pipeline can realize being connected with dismantling of whole liver perfusion device 24, then can change whole liver perfusion device 24 in order to realize the alternative use of multiple treatment template, realize reaching the treatment purpose of different modes in a biological artificial liver system, thereby alleviate patient's economic burden, dismantle it when need not to use whole liver perfusion device 24 again simultaneously, and deposit whole liver perfusion device 24 properly, in order to prolong whole liver perfusion device 24's live time. Moreover, the connectors on the pipelines are convenient to connect and easy to disassemble and assemble, and the assembly efficiency of the special pipelines is improved.
The foregoing is only a partial embodiment of the present application, and it should be noted that, for those skilled in the art, several modifications and decorations can be made without departing from the principle of the present application, and these modifications and decorations should also be regarded as the protection scope of the present application.
Claims (9)
1. A special pipeline of a total-liver type bioartificial liver system is characterized in that: comprises a plasma separating pipeline, a blood storage tank, a blood leading pipeline of the blood storage tank, a hepatic anterior pipeline, a hepatic posterior pipeline and a total hepatic perfusion device;
the plasma separation pipeline comprises a plasma separation conduit and a plasma separation pump, the plasma separation conduit is connected with the input end of the blood storage tank to input receptor plasma, the plasma separation conduit is connected with a first plasma separator, the first plasma separator is connected with an arterial conduit and a venous conduit, the plasma separation conduit, the arterial conduit and the venous conduit form plasma separation circulation, the arterial conduit comprises an arterial conduit connected with a blood drawing deep venous conduit preset in a receptor, a blood suction pump and an arterial kettle are arranged on the arterial conduit, the venous conduit comprises a venous conduit connected with the receptor vein, and a venous kettle is arranged on the venous conduit;
the blood storage tank blood-leading pipeline comprises a blood-leading conduit and a blood-leading pump, the hepatic anterior pipeline comprises a hepatic anterior conduit, the hepatic posterior pipeline comprises a hepatic posterior conduit, the blood-leading conduit, the hepatic anterior conduit and the hepatic posterior conduit are sequentially connected in a direction from the output end to the input end of the blood storage tank, and the total liver perfusion device is arranged between the hepatic anterior conduit and the hepatic posterior conduit;
the whole liver perfusion device is used for purifying receptor plasma, the blood storage tank blood leading pipeline, the pre-hepatic pipeline, the post-hepatic pipeline and the whole liver perfusion device form an extracorporeal liver perfusion circulation, and the plasma separation pipeline and the extracorporeal liver perfusion circulation are connected in parallel through the blood storage tank;
the second plasma separator is provided with a second blood inlet, a second plasma outlet and a second blood cell outlet, the second blood inlet is connected with the output end of the blood storage tank, the circulating pipeline comprises a blood guide pipe and a circulating pipe, the second plasma separator is arranged between the blood guide pipe and the circulating pipe, the blood guide pipe is connected with the output end of the blood storage tank, a blood guide pump is arranged on the blood guide pipe, and the circulating pipe is connected with the input end of the blood storage tank; the plasma return pipeline comprises a plasma return conduit and a plasma return pump, one end of the plasma return conduit is connected with the second plasma outlet, and the other end of the plasma return conduit is connected with the venous kettle of the venous pipeline.
2. The dedicated line for a total liver type bioartificial liver system as claimed in claim 1, wherein: a peristaltic pump is arranged between the blood guide catheter and the hepatic anterior catheter.
3. The dedicated line for a total liver type bioartificial liver system as claimed in claim 1, wherein: the plasma separation pipeline is connected with a first plasma separator, and the first plasma separator is provided with a first blood inlet, a first plasma outlet and a first blood cell outlet;
the plasma separating pipeline is connected with the first plasma outlet, the first blood inlet is connected with the arterial pipeline, and the blood cell outlet of the first plasma separator is connected with the venous pipeline.
4. The dedicated line for a total liver type bioartificial liver system as claimed in claim 3, wherein: the arterial pot is provided with at least three joints; the venous pot is provided with at least four connectors.
5. The dedicated line for a total liver type bioartificial liver system as claimed in claim 4, wherein: and the arterial pipeline and the venous pipeline are connected with a medicine input device.
6. The dedicated line for a total liver type bioartificial liver system as claimed in claim 1, wherein: the output end of the blood storage tank is connected with the blood guide pipe of the blood guide pipeline of the blood storage tank and the blood guide pipe of the circulating pipeline through a three-way valve.
7. The dedicated line for a total liver type bioartificial liver system as claimed in claim 1, wherein: still include a plurality of pressure measurement, locate respectively on arteria kettle, venous pot, first plasma separator, second plasma separator, preceding pipe of liver and the pipe behind the liver.
8. The dedicated line for a total liver type bioartificial liver system as claimed in claim 1, wherein: the whole liver perfusion device comprises a whole liver and a perfusion cabin body, the whole liver adopts an animal liver, and the whole liver perfusion device is connected with a bile recovery device.
9. The dedicated line for a total liver type bioartificial liver system as claimed in claim 1, wherein: the ports of the special pipeline are realized in the following forms:
the male joint consists of a tubular joint, the front end of the tubular joint is provided with a connecting part, the outer side wall of the tubular joint is provided with an armrest part, and the tubular joint can coaxially rotate relative to a pipe body connected with the tubular joint;
the female joint comprises a bearing part matched with the connecting part and is fixedly connected to the port of the pipeline.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011407993.6A CN112604048B (en) | 2020-12-04 | 2020-12-04 | Special pipeline for total-liver type bioartificial liver support system |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011407993.6A CN112604048B (en) | 2020-12-04 | 2020-12-04 | Special pipeline for total-liver type bioartificial liver support system |
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| CN112604048A CN112604048A (en) | 2021-04-06 |
| CN112604048B true CN112604048B (en) | 2021-09-17 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003250882A (en) * | 2001-12-28 | 2003-09-09 | Katsutoshi Naruse | Artificial organ system using new perfusion method |
| KR100886003B1 (en) * | 2007-03-30 | 2009-03-03 | (주)라이프코드 | Bioartificial Systems Using Gel Bead Filled Bioreactors |
| CN201320317Y (en) * | 2008-12-26 | 2009-10-07 | 南京大学医学院附属鼓楼医院 | Hybrid biological artificial liver extracorporeal supporting device |
| CN104971391A (en) * | 2015-06-19 | 2015-10-14 | 南方医科大学珠江医院 | Novel combined type liver and kidney support system CRRT mode tube |
| KR101931854B1 (en) * | 2015-08-27 | 2018-12-24 | 라이프리버 주식회사 | peritoneal circulation apparatus and bioartificial liver support system using the same |
| CN105379707B (en) * | 2015-12-16 | 2017-10-17 | 浙江大学 | Liver normal temperature irrigates repair system |
| CN206228667U (en) * | 2016-08-26 | 2017-06-09 | 合肥市力维生物科技有限公司 | A kind of Biotype artificial liver |
| JP6950887B2 (en) * | 2017-04-28 | 2021-10-13 | 米満 吉和 | Extracorporeal artificial liver and equipment for extracorporeal artificial liver or hepatocyte culture |
| CN108211032B (en) * | 2018-02-01 | 2023-11-17 | 南方医科大学珠江医院 | Combined bioartificial liver support system |
| CN110478548A (en) * | 2019-07-31 | 2019-11-22 | 南方医科大学珠江医院 | Bioartificial liver system |
| CN112604051B (en) * | 2020-12-04 | 2021-09-17 | 广东乾晖生物科技有限公司 | Total-liver type bioartificial liver system |
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2020
- 2020-12-04 CN CN202011407993.6A patent/CN112604048B/en active Active
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