CN112603603A - Personalized prosthesis with antibacterial and bone promoting effects and its preparation method - Google Patents
Personalized prosthesis with antibacterial and bone promoting effects and its preparation method Download PDFInfo
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- CN112603603A CN112603603A CN202110128919.9A CN202110128919A CN112603603A CN 112603603 A CN112603603 A CN 112603603A CN 202110128919 A CN202110128919 A CN 202110128919A CN 112603603 A CN112603603 A CN 112603603A
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Abstract
The invention discloses a personalized prosthesis with antibacterial and bone-promoting effects and a manufacturing method thereof. Personalized prosthesis surface coating with Li-containing+、Zn2+、Cu2+Of a bioceramic slurry of, Zn2+And Cu2+Can have bactericidal and antibacterial effects, Li+And the biological ceramic can promote the proliferation and differentiation of cells, thereby promoting the residual bones of the human bodyReliability and safety of connection with personalized prostheses, particularly for the repair of infectious bone defects. The personalized prosthesis manufactured by the invention not only has good mechanical property, but also can resist bacteria and inhibit infection in the early stage, and continuously promotes the integration of the residual bones of the human body and the personalized prosthesis in the later stage.
Description
Technical Field
The invention belongs to the technical field of personalized prosthesis manufacturing, and particularly relates to a personalized prosthesis with antibacterial and bone promoting effects and a manufacturing method thereof.
Background
The treatment of infectious bone diseases is a great problem in orthopedics clinic, inflammatory stimulation exists in the local infected bone defect focus, so that local osteoblasts are insufficient, bone regeneration capacity is low, and a plurality of microenvironment factors which are not beneficial to bone formation are caused, and the phenomenon that the remaining bones of a human body are difficult to be well integrated with a personalized prosthesis implant to cause prosthesis loosening is easy to occur in the later period. Due to the special bone defect of the infected part, the disease condition is complex, the disease course is long, and the clinical application has the characteristics of high infection recurrence rate and difficult cure. Such diseases impose a heavy economic burden on patients, greatly reduce the quality of life of patients, and consume a large amount of medical and public resources.
At present, focus cleaning is mainly adopted clinically, bone grafting and antibiotic treatment are mainly adopted. However, the autologous bone transplantation for treating bone defects has the defects of damaging a supply area, causing secondary damage and the like, and meanwhile, the autologous bone source is limited and is difficult to be used for treating larger bone defects; in addition, allogeneic bone also has the disadvantages of disease transmission, rejection, and the like. At present, the conventional antibiotic treatment has the defects of short acting time, low local blood concentration of a focus, high administration cost due to frequent injection, poor patient compliance, aggravation of physical, psychological and economic burdens of a patient and the like, and if the antibiotic with high concentration is locally applied, the growth of osteoblasts and endothelial cells can be inhibited to further influence the fracture healing. Therefore, aiming at the local pathological characteristics of the focus, how to cure and repair infectious bone defects more safely and effectively is a huge challenge and research hotspot facing the orthopedics department at present.
In recent years, a great deal of domestic research focuses on the development of a sustained-release system of a bone repair material loaded with local antibiotics, and a series of researches prove that allogeneic bone composite gentamicin, tobramycin-loaded calcium sulfate pellets are compounded with demineralized bone matrix, and drug-loaded self-setting calcium phosphate bone cement is combined with allogeneic bone, thereby improving the bone qualityThe glue combined heterogenic deproteinized bone composite antibiotic bone grafting material, the drug-loaded nano hydroxyapatite composite glue raw material and the like can be absorbed in vivo and have certain anti-infection and bone conduction effects. However, the drug-loaded repairing stent still has the risks of bringing adverse reactions to organisms and drug resistance of bacteria due to abuse of antibiotics. Therefore, the personalized prosthesis manufactured by the invention has the dual functions of antibiosis and bone promotion, and can adapt to bone defects in any shape and any position; zn coating sintered personalized prosthesis surface2+And Cu2+The metal ions can be quickly released in the early stage to play the roles of sterilization and antibiosis, and the problem of drug resistance of antibiotics is avoided; li+And the biological ceramics can slowly release to promote the proliferation and differentiation of cells, thereby promoting the rapid repair of bone defects and the replacement of personalized prosthesis.
Disclosure of Invention
The invention aims to provide a personalized prosthesis with antibacterial and bone promoting effects and a manufacturing method thereof aiming at solving the problems of complex disease condition, long disease course, high infection recurrence rate in clinic, difficult healing and the like in the conventional infectious bone defect repair and aiming at promoting the rapid repair of the infectious bone defect+、Zn2+、Cu2+Of a bioceramic slurry of, Zn2+And Cu2+Can have bactericidal and antibacterial effects, Li+And the biological ceramic can promote the proliferation and differentiation of cells, further promote the reliability and safety of the connection of the residual bones of the human body and the personalized prosthesis, and is particularly suitable for the personalized repair of infectious bone defects.
The invention is realized by adopting the following technical scheme:
a personalized prosthesis with antibacterial and bone promoting effects comprises a base body mainly bearing acting force and a contact surface positioned on the base body and in fit connection with residual bones of a human body; wherein,
the contact surface is designed into a layer of porous structure with regularity or light weight structure with randomness to form a layer of porous structure with thickness of 0.5-3mm, porosity of 5-30% and pore size of 0.5-3mm, and the porous structure is extended into the basal body, and the basal body and the contact surface are two parts of the same prosthesis and are integrally formed during manufacturing;
the personalized prosthesis surface is coated with a coating containing Li+、Zn2+、Cu2+Of a bioceramic slurry of, Zn2+And Cu2+Can have bactericidal and antibacterial effects, Li1+And the biological ceramic can promote the proliferation and differentiation of cells, further promote the reliability and safety of the connection of the residual bones of the human body and the personalized prosthesis, and is particularly suitable for the repair of infectious bone defects.
The invention is further improved in that the porosity and pore size of the regular porous structure or the random lightweight structure on the contact surface of the personalized prosthesis can be adjusted through structural design according to the stress condition of the prosthesis and the size of the prosthesis.
A method for manufacturing a personalized prosthesis with antibacterial and bone promoting effects comprises the following steps:
1) design of personalized prosthesis and preparation of printed document
And reconstructing CT data of a patient into a three-dimensional model, and designing a personalized prosthesis initial solid model meeting requirements according to a doctor operation scheme based on the three-dimensional model. And determining the thickness, the pore size and the porosity of the porous structure layer according to the stress condition and the installation requirement of the prosthesis. And finally, carrying out layered slicing treatment on the designed final prosthesis model.
2) Personalized prosthesis manufacture
According to the actual application requirements, guiding the processed slice files into different types of 3D printers for direct printing and forming, and performing post-processing operations such as support removal, polishing, heat treatment and the like; or a mould of the personalized prosthesis is firstly manufactured, and then the personalized prosthesis is obtained by injection molding or casting.
3) Preparation of antibacterial and bone promoting slurry
Compound powder containing Li, Zn and Cu elements and biological ceramic powder are mixed, and distilled water is used as a solvent to prepare mixed slurry with a certain concentration.
4) Coating and sintering the slurry
And (3) placing the personalized prosthesis manufactured in the step 2) into the mixed slurry prepared in the step 3), and placing the personalized prosthesis into a sintering furnace for sintering after the personalized prosthesis is coated stably. The sintering temperature is 200-250 ℃, and the sintering time is 5-30min, so as to obtain the final personalized prosthesis with the antibacterial and bone promoting effects.
A further development of the invention is that in step 2) the personalized prosthesis is shaped directly by 3D printing techniques or indirectly by 3D printing techniques. Wherein, the direct molding method is to manufacture personalized polyether-ether-ketone and composite material prosthesis thereof by a material extrusion process or manufacture personalized titanium alloy prosthesis by a powder bed melting process; the indirect forming method is to manufacture a mold by using a 3D printing technology, manufacture personalized polyether-ether-ketone and composite material prosthesis thereof by using an injection molding technology or manufacture personalized titanium alloy prosthesis by using a casting technology.
The invention is further improved in that the compound containing Li in the step 3) is LiCl, and the compound containing Zn is ZnCl2Or ZnSO4The compound containing Cu is CuCl2Or CuSO4The biological ceramic is one or a combination of several of hydroxyapatite, tricalcium phosphate, calcium silicate, zirconia and titanium dioxide.
The further improvement of the invention is that Zn in the slurry solution in the step 3)2+And Cu2+In a molar ratio of 1:10 to 10:1, Li+The mol ratio of the zinc oxide to the biological ceramic is 1:10-10:1, Zn2+And Cu2+Total content of (2) and Li+The molar ratio of the biological ceramic to the total content of the biological ceramic is 1:2-2:1, and the mass concentration of the mixed slurry is 10-40%.
The invention has the following beneficial technical effects:
1. the personalized prosthesis can meet the personalized requirements of any part only by using a material extrusion process 3D printer or a powder bed melting process 3D printer, so that the manufacturing process is simple, the equipment and manpower and material resource expenses are reduced, and the manufacturing cost is reduced by 20-30%;
2. the performance of the personalized prosthesis is controllable, and can be selected in three aspects according to the actual application requirement: 1) when the prosthesis is designed, the pore size and the porosity of the porous structure of the contact surface (2) part are adjusted; 2) different materials may be selected when printing the personalized prosthesis; 3) direct printing molding or indirect injection molding and casting molding can be selected, and the latter has more excellent comprehensive mechanical properties;
3.Zn2+and Cu2+Can effectively play the role of sterilization and antibiosis, solves the problem of drug resistance generated by clinical antibiotics, and Li+The biological ceramic can rapidly promote the proliferation and differentiation of cells, further promote the reliability and safety of the connection of the residual bones of the human body and the personalized prosthesis, and has lower cost;
4. the personalized prosthesis comprises a base part and a contact surface part, wherein the contact surface part is directly connected and matched with the residual bones of the human body, so that the designed porous structure can increase Li near the contact surface part+、Zn2+、Cu2+And the content of the biological ceramic, thus promoting the cell proliferation and differentiation after the inflammation of the connecting part is abated better, on the other hand, the porous structure can provide a larger space for the bone growth, and the bone growing into the porous structure can further enhance the reliability and the safety of the connection between the personalized prosthesis and the residual bone of the human body;
5. the personalized prosthesis comprises a base part and a contact surface part, wherein the base part is matched with soft tissues and the joint socket, so that the appearance is smooth, the soft tissues are prevented from being damaged, and the contact surface part is designed into a porous structure by considering the condition of the advantage 4. Therefore, the design has better structural rationality and practicability;
6. the sintering process can ensure Li+、Zn2+、Cu2+And the bioceramic has high adhesion with the personalized prosthesis.
Drawings
FIG. 1 is a personalized prosthesis having a solid base portion and a porous structured joint face portion according to the invention;
FIG. 2 is a process flow diagram of the present invention.
Detailed Description
The invention is further described below with reference to the following figures and examples.
Example 1
As shown in figure 1, the personalized prosthesis with both antibacterial and bone promoting effects comprises a base body 1 mainly bearing acting force and a contact surface 2 positioned on the base body and in fit connection with the residual bones of a human body; wherein, the contact surface 2 is designed into a layer of porous structure with regularity or light weight structure with randomness to form a layer of porous structure with thickness of 0.5-3mm, porosity of 5-30% and pore size of 0.5-3mm, and the porous structure is extended into the basal body, and the basal body and the contact surface are two parts of the same prosthesis, and are integrally formed during manufacturing.
The porosity and pore size of the regular porous structure or the random lightweight structure on the contact surface 2 of the personalized prosthesis can be adjusted through structural design according to the stress condition of the prosthesis and the size of the prosthesis.
The personalized prosthesis surface is coated with a coating containing Li1+、Zn2+、Cu2+Of a bioceramic slurry of, Zn2+And Cu2+Can have bactericidal and antibacterial effects, Li+And the biological ceramic can promote the proliferation and differentiation of cells, further promote the reliability and safety of the connection of the residual bones of the human body and the personalized prosthesis, and is particularly suitable for the repair of infectious bone defects.
Example 2
The manufacturing method of the personalized prosthesis with both antibacterial and bone promoting effects of the embodiment is as follows:
(1) the CT data of a patient are imported into the mimics software to be reconstructed into a three-dimensional model, and based on the three-dimensional model, a personalized prosthesis initial entity model meeting the requirements is designed in the 3-matic software according to the operation scheme of a doctor. The thickness of the porous structure layer is determined to be 3mm, the pore size is determined to be 3mm and the porosity is determined to be 30% according to the stress condition and the installation requirement of the prosthesis. And (3) guiding the designed personalized prosthesis with the solid part and the porous structure part into Jugao AM slicing software to slice in a layer thickness of 0.1mm, selecting concentric circles for filling according to a filling scheme, and adding a support structure. And (3) guiding the slice file into a Shaanxi poly high polyether-ether-ketone 3D printer for printing, and carrying out post-treatment processes such as support removal, grinding and heat treatment on the printed part to obtain the personalized polyether-ether-ketone prosthesis.
(2) Mixing compound powder containing Li, Zn and Cu elements with bioceramic powder to prepare mixed slurry with mass concentration of 40%, wherein Zn is contained in the slurry2+And Cu2+In a molar ratio of 1:10, Li+The mol ratio of the zinc oxide to the bioceramic is 1:10, Zn2+And Cu2+Total content of (2) and Li+1And the total content of the biological ceramics is 1:2 in a molar ratio; and (3) putting the manufactured personalized prosthesis into the prepared mixed slurry, and sintering in a sintering furnace after the personalized prosthesis is stably coated. The sintering temperature is 200 ℃, the sintering time is 5min, and the final personalized polyether-ether-ketone prosthesis with the antibacterial and bone-promoting effects is obtained.
Example 3
The manufacturing method of the personalized prosthesis with both antibacterial and bone promoting effects of the embodiment is as follows:
(1) the CT data of a patient are imported into the mimics software to be reconstructed into a three-dimensional model, and based on the three-dimensional model, a personalized prosthesis initial entity model meeting the requirements is designed in the 3-matic software according to the operation scheme of a doctor. The thickness of the porous structure layer is 0.5mm, the pore size is 0.5mm and the porosity is 5% according to the stress condition and the installation requirement of the prosthesis. The designed personalized prosthesis with the solid part and the porous structure part is introduced into Renishaw Quant AM slicing software to be sliced with the thickness of 0.03mm, and a support structure is added. And (3) guiding the sliced file into a RenAm500 model 3D printer in RenAN _ SNao in England for printing, and carrying out post-treatment processes such as support removal, grinding, heat treatment and the like on the printed part to obtain the personalized titanium alloy prosthesis.
(2) Compound powder containing Li, Zn and Cu elements was mixed with bioceramic powder to prepare mixed slurry having a mass concentration of 10%. Zn in the slurry2+And Cu2+In a molar ratio of 10:1, Li+The molar ratio of the zinc oxide to the bioceramic is 10:1, Zn2+And Cu2+Total content of (2) and Li+And the total bioceramic content in a molar ratio of 2: 1. And (3) putting the manufactured personalized prosthesis into the prepared mixed slurry, and sintering in a sintering furnace after the personalized prosthesis is stably coated. The sintering temperature is 250 ℃, the sintering time is 30min, and the final personalized titanium alloy prosthesis with the antibacterial and bone promoting effects is obtained.
It is clear that the embodiments described above are only two embodiments of the invention, not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (6)
1. A personalized prosthesis with both antibacterial and osteogenesis promoting effects, characterized by: the personalized prosthesis comprises a base body (1) bearing acting force and a contact surface (2) which is positioned on the base body (1) and is in fit connection with residual bones of a human body; wherein,
the contact surface (2) is designed into a layer of porous structure with regularity or light weight structure with randomness to form a layer of porous structure with thickness of 0.5-3mm, porosity of 5-30% and pore size of 0.5-3mm, and the porous structure is extended into the base body (1), and the base body (1) and the contact surface (2) are two parts of the same prosthesis and are integrally formed during manufacturing;
the personalized prosthesis surface is coated with a coating containing Li+、Zn2+、Cu2+The bioceramic slurry of (1).
2. The personalized prosthesis having both antibacterial and osteogenic effects of claim 1, wherein: the porosity and pore size of the regular porous structure or the random lightweight structure on the contact surface (2) can be adjusted through structural design according to the stress condition of the prosthesis and the size of the prosthesis.
3. Method for manufacturing a personalized prosthesis with both antibacterial and osteopromotive action according to claim 1 or 2, characterized in that it comprises the following steps:
1) design of personalized prosthesis and preparation of printed document: reconstructing CT data of a patient into a three-dimensional model, designing a personalized prosthesis initial solid model meeting requirements according to a doctor operation scheme based on the three-dimensional model, determining the thickness of a porous structure layer, the size of pores and the porosity according to the stress condition and the installation requirement of the prosthesis, and finally, carrying out layered slicing treatment on the designed final prosthesis model;
2) personalized prosthesis manufacturing: according to the actual application requirements, guiding the processed slice files into different types of 3D printers for direct printing and forming, and carrying out support removing, polishing and heat treatment operations; or firstly manufacturing a die of the personalized prosthesis, and then obtaining the personalized prosthesis in an injection molding or casting mode;
3) preparation of slurry with antibacterial and bone-promoting effects: mixing compound powder containing Li, Zn and Cu elements and biological ceramic powder by using distilled water as a solvent to prepare mixed slurry with a certain concentration;
4) coating and sintering the slurry: and (3) placing the personalized prosthesis manufactured in the step 2) into the mixed slurry prepared in the step 3), placing the personalized prosthesis into a sintering furnace for sintering after the personalized prosthesis is coated and stabilized, wherein the sintering temperature is 200-.
4. The method of claim 3, wherein the personalized prosthesis is manufactured directly by 3D printing or indirectly by 3D printing; wherein, the direct molding method is to manufacture personalized polyether-ether-ketone and composite material prosthesis thereof by a material extrusion process or manufacture personalized titanium alloy prosthesis by a powder bed melting process; the indirect forming method is to manufacture a mold by using a 3D printing technology, manufacture personalized polyether-ether-ketone and composite material prosthesis thereof by using an injection molding technology or manufacture personalized titanium alloy prosthesis by using a casting technology.
5. The composition of claim 3 having antibacterial and osteogenic propertiesThe manufacturing method of the personalized prosthesis is characterized in that the compound containing Li is LiCl, and the compound containing Zn is ZnCl2Or ZnSO4The compound containing Cu is CuCl2Or CuSO4The biological ceramic is one or a combination of several of hydroxyapatite, tricalcium phosphate, calcium silicate, zirconia or titanium dioxide.
6. The method of claim 5, wherein Zn is added to the mixed slurry2+And Cu2+In a molar ratio of 1:10 to 10:1, Li+The mol ratio of the zinc oxide to the biological ceramic is 1:10-10:1, Zn2+And Cu2+Total content of (2) and Li1+The molar ratio of the biological ceramic to the total content of the biological ceramic is 1:2-2:1, and the mass concentration of the mixed slurry is 10-40%.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114146218A (en) * | 2021-12-03 | 2022-03-08 | 中国人民解放军空军军医大学 | Artificial bone made of porous PEEK material and preparation method thereof |
| CN115414159A (en) * | 2022-09-19 | 2022-12-02 | 中国人民解放军联勤保障部队第九二〇医院 | Artificial scaphoid prosthesis and preparation method and preparation tool thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105688276A (en) * | 2008-02-29 | 2016-06-22 | 史密夫和内修有限公司 | Gradient coating for biomedical applications |
| CN109091273A (en) * | 2018-06-13 | 2018-12-28 | 西安交通大学 | A kind of personalized pelvis endoprosthesis designs method based on topological structure optimization |
| CN110565144A (en) * | 2018-11-01 | 2019-12-13 | 赵全明 | Porous biological ceramic coating with antibacterial and bone-promoting functions and preparation method and application thereof |
-
2021
- 2021-01-29 CN CN202110128919.9A patent/CN112603603A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105688276A (en) * | 2008-02-29 | 2016-06-22 | 史密夫和内修有限公司 | Gradient coating for biomedical applications |
| CN109091273A (en) * | 2018-06-13 | 2018-12-28 | 西安交通大学 | A kind of personalized pelvis endoprosthesis designs method based on topological structure optimization |
| CN110565144A (en) * | 2018-11-01 | 2019-12-13 | 赵全明 | Porous biological ceramic coating with antibacterial and bone-promoting functions and preparation method and application thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114146218A (en) * | 2021-12-03 | 2022-03-08 | 中国人民解放军空军军医大学 | Artificial bone made of porous PEEK material and preparation method thereof |
| CN115414159A (en) * | 2022-09-19 | 2022-12-02 | 中国人民解放军联勤保障部队第九二〇医院 | Artificial scaphoid prosthesis and preparation method and preparation tool thereof |
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