CN112603601A - High-strength bone repair support and manufacturing method thereof - Google Patents
High-strength bone repair support and manufacturing method thereof Download PDFInfo
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- CN112603601A CN112603601A CN202011603728.5A CN202011603728A CN112603601A CN 112603601 A CN112603601 A CN 112603601A CN 202011603728 A CN202011603728 A CN 202011603728A CN 112603601 A CN112603601 A CN 112603601A
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- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 124
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 21
- 230000000975 bioactive effect Effects 0.000 claims abstract description 31
- 239000000017 hydrogel Substances 0.000 claims abstract description 31
- 239000000463 material Substances 0.000 claims abstract description 31
- 239000007787 solid Substances 0.000 claims abstract description 30
- 230000007547 defect Effects 0.000 claims abstract description 20
- 239000000203 mixture Substances 0.000 claims abstract description 7
- 239000002131 composite material Substances 0.000 claims abstract description 4
- 239000011148 porous material Substances 0.000 claims description 23
- 238000005516 engineering process Methods 0.000 claims description 8
- FGZBFIYFJUAETR-UHFFFAOYSA-N calcium;magnesium;silicate Chemical compound [Mg+2].[Ca+2].[O-][Si]([O-])([O-])[O-] FGZBFIYFJUAETR-UHFFFAOYSA-N 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 6
- 238000010146 3D printing Methods 0.000 claims description 5
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 5
- 238000002513 implantation Methods 0.000 claims description 4
- 229910019142 PO4 Inorganic materials 0.000 claims description 3
- 238000010382 chemical cross-linking Methods 0.000 claims description 3
- 238000004132 cross linking Methods 0.000 claims description 3
- 239000010452 phosphate Substances 0.000 claims description 3
- 238000005245 sintering Methods 0.000 claims description 3
- 239000011230 binding agent Substances 0.000 claims 2
- 230000008929 regeneration Effects 0.000 abstract description 4
- 238000011069 regeneration method Methods 0.000 abstract description 4
- 238000002791 soaking Methods 0.000 description 6
- 230000001678 irradiating effect Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 230000004071 biological effect Effects 0.000 description 2
- 230000010478 bone regeneration Effects 0.000 description 2
- 238000001354 calcination Methods 0.000 description 2
- 239000004137 magnesium phosphate Substances 0.000 description 2
- 229960002261 magnesium phosphate Drugs 0.000 description 2
- 229910000157 magnesium phosphate Inorganic materials 0.000 description 2
- 235000010994 magnesium phosphates Nutrition 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 239000003462 bioceramic Substances 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30772—Apertures or holes, e.g. of circular cross section
- A61F2002/30784—Plurality of holes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
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- General Health & Medical Sciences (AREA)
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- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
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Abstract
The invention discloses a high-strength bone repair bracket and a manufacturing method thereof, wherein the bracket consists of 3 parts of an upper combined body, a bracket main body and a lower combined body, the lower surface of the upper combined body is contacted with the upper surface of the bracket main body, the lower surface of the bracket main body is contacted with the upper surface of the lower combined body, the bracket main body is made of a bioactive material, and the upper combined body and the lower combined body are both a mixture of the bioactive material and hydrogel. The main body of the bracket is a composite of a porous structure and a solid structure, the porous structure is distributed at the periphery and inside, the inside of the upper combination body and the lower combination body is of a porous structure or a solid structure, and the hydrogel is filled in grids of the bioactive material. The invention has high mechanical strength, can ensure that the bracket still has a stable space structure when being subjected to high load force, has good bonding performance, can ensure that the bracket is stably fixed at a bone defect part, has good bioactivity and promotes the regeneration and repair of bone tissues.
Description
Technical Field
The invention relates to the technical field of tissue engineering, in particular to a high-strength bone repair scaffold and a manufacturing method thereof.
Background
The bone repair scaffold is a medical instrument which is commonly used for treating large bone defects in clinic and can promote regeneration and repair of bone tissues. Currently, the bone repair scaffold most studied by people is a bioceramic bone repair scaffold, which can release various ions to stimulate new bone regeneration. In order to better realize the repair of large-section bone defects, the bone repair scaffold is required to have high mechanical property, so that the whole scaffold structure can maintain a certain shape when being subjected to a load force, the new bone tissues can grow into the scaffold smoothly until the load force born by the new bone is larger and larger, and finally, the bone repair scaffold disappears completely when being born by the new bone. However, the current bone repair scaffold has poor mechanical strength, is easily deformed when subjected to a load, and causes difficulty in the growth of new bone due to the blockage of internal pores or structural collapse. In addition, in practical applications, when a bone repair scaffold is implanted into a bone defect, because both ends of the bone repair scaffold and surrounding bones are hard and the shape of the bone repair scaffold is not highly matched with the shape of the bone defect, the bone repair scaffold cannot maintain a fixed position at the bone defect, and is easy to loosen, shift or fall off, so that the bone repair scaffold is separated from an ideal position during implantation, and the treatment effect of the bone defect is affected.
Therefore, it is necessary to design a new bone repair scaffold with good mechanical strength and performance, which can ensure that a stable spatial structure is maintained under the action of an external loading force after the scaffold is implanted, so that new bones can smoothly grow into the scaffold, and which has good bioactivity, can promote bone tissue regeneration, and simultaneously has good binding performance with surrounding bones, thereby ensuring the stability of the bone repair scaffold at a bone defect part.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides a high-strength bone repair bracket and a manufacturing method thereof.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
a high-strength bone repair scaffold is composed of an upper combined body, a scaffold main body and a lower combined body, wherein the lower surface of the upper combined body is in contact with the upper surface of the scaffold main body, the lower surface of the scaffold main body is in contact with the upper surface of the lower combined body, the scaffold main body is made of bioactive materials and has high mechanical strength, the bioactive materials can be calcium magnesium silicate, phosphate and silicate and can also be a mixture of the calcium magnesium silicate, the phosphate and the silicate, and the upper combined body and the lower combined body are both a mixture of the bioactive materials and hydrogel.
The scaffold main body is a composite of a porous structure and a solid structure, the porous structure is distributed at the periphery and inside, the pore diameter is 100-80 microns, the porosity is 30-80%, a plurality of solid structures are uniformly distributed in the middle, and can be 3, 4, 6 and the like, new bones can grow into the scaffold main body along pore channels in the porous structure, the effect of promoting bone defect regeneration and repair is achieved, meanwhile, as the new bones grow into the scaffold main body, the bonding performance between the scaffold main body and surrounding bones is slowly increased, and finally the scaffold main body and the surrounding bones are fused into a whole.
Preferably, the solid structure of the bracket main body has a thickness of 300 micrometers-5 millimeters, and the solid structure plays a role in bearing external load force, so that the bracket is ensured to have a stable spatial structure.
In order to make the bone repair scaffold have high mechanical strength, the high mechanical strength can be realized by changing the pore diameter, the porosity or the size of a solid structure inside the scaffold body. The solid structure in the stent main body can also be a hollow annular structure, even the periphery of the stent main body is a porous structure, and the interior of the stent main body is a solid structure.
The shape of the upper combination body or the lower combination body can be changed according to the requirement, and the upper combination body or the lower combination body can be the same with or different from the shape of the bracket main body and can be in a circular shape, a rectangular shape or other shapes. In practical application, the shape of the upper combined body or the lower combined body matched with the shape of the contact part of the bone repair bracket and the surrounding bone can be designed and manufactured.
Preferably, the thickness of the upper combination body or the lower combination body is 100 micrometers-5 millimeters.
The inner part of the upper combination body or the lower combination body is of a porous structure or a solid structure, the bioactive material part is of a porous structure, the porosity of the bioactive material part is 40% -80%, the pore diameter is 100-1500 microns, and the hydrogel is filled in the pore channels in the bioactive material.
Preferably, the hydrogel is on the surface of the bioactive material, and can fill the pores of the bioactive material.
Preferably, the hydrogel can be a hydrogel with photosensitive crosslinking property, and can also be a hydrogel with chemical crosslinking property.
The bone repair support has good mechanical property and biological activity, in the early stage of bone repair, an upper combination body and a lower combination body of the bone repair support are respectively contacted with surrounding bones of a bone defect part to quickly form stable and firm binding force, so that the bone repair support is stably fixed on the bone defect part, and meanwhile, along with the increase of implantation time, a plurality of new bone tissues grow into the main body part of the bone repair support to further fix the bone repair support, so that the bone repair support has better bone repair performance.
The invention relates to a manufacturing method of the high-strength bone repair bracket, which comprises the following steps:
1) selecting proper bioactive materials according to requirements, and designing a main structure, an upper combined body structure and a lower combined body structure of the bracket according to application occasions;
2) manufacturing a support blank by using a 3D printing technology or other manufacturing technologies;
3) placing the support blank into a high-temperature furnace for high-temperature sintering, and cooling to obtain a support;
4) mixing the upper combined body part of the scaffold with hydrogel to obtain a semi-finished scaffold;
5) and mixing the lower combined body part of the semi-finished scaffold with the hydrogel to obtain the high-strength bone repair scaffold.
When the bone repair stent is manufactured into a stent blank, the bioactive material parts of the stent main body, the upper combination body and the lower combination body are manufactured simultaneously.
Compared with the prior art, the invention has the following advantages:
firstly, the invention can manufacture the bone repair bracket with high associativity, so that the bone repair bracket can be fixed on the bone defect part more quickly and stably.
The invention can manufacture the bone repair bracket with high mechanical strength, so that the new bone tissue can smoothly grow into the bracket.
And thirdly, the method for manufacturing the high-strength bone repair bracket is convenient to operate and low in manufacturing cost.
Fourthly, the high-strength bone repair bracket manufactured by the invention has good bioactivity and good bone regeneration and repair performance.
The shape and the structure of the upper and lower combination bodies can be designed and changed according to the requirements, so that the high-strength bone repair support is suitable for different application environments.
Drawings
FIG. 1 is a schematic flow chart of a method of manufacturing a high strength bone repair scaffold of the present invention;
FIG. 2 is a schematic structural view of a high strength bone repair scaffold of the present invention;
fig. 3 is a schematic structural view of a main body of the high-strength bone repair scaffold of the present invention.
Detailed Description
The following examples are given for the detailed implementation and specific operation of the present invention, but the scope of the present invention is not limited to the following examples.
The invention relates to a high-strength bone repair bracket which comprises 3 parts of an upper combined body, a bracket main body and a lower combined body, wherein the lower surface of the upper combined body is contacted with the upper surface of the bracket main body, the lower surface of the bracket main body is contacted with the upper surface of the lower combined body, the bracket main body is made of bioactive materials and has high mechanical strength, the bioactive materials can be calcium magnesium silicate, phosphate and silicate, and can also be mixtures of the calcium magnesium silicate, the phosphate and the silicate, and the upper combined body and the lower combined body are mixtures of the bioactive materials and hydrogel.
The main body of the bracket is a composite of a porous structure and a solid structure, the porous structure is distributed at the periphery and inside, the pore diameter is 100-600 microns, the porosity is 30% -80%, a plurality of solid structures are uniformly distributed in the middle, and can be 3, 4, 6 and the like, new bones can grow into the main body of the bracket along the pore channels in the porous structure, the effect of promoting the regeneration and repair of bone defects is achieved, meanwhile, as the new bones grow into the main body of the bracket, the bonding performance between the main body of the bracket and surrounding bones is also slowly increased, and the main body of the bracket and the surrounding bones are finally fused into a whole.
The solid structure of the stent main body has the size of 300 micrometers-5 millimeters in thickness.
In order to make the bone repair scaffold have high mechanical strength, the high mechanical strength can be realized by changing the pore diameter, the porosity or the size of a solid structure inside the scaffold body. The solid structure in the stent main body can also be a hollow annular structure, even the periphery of the stent main body is a porous structure, and the interior of the stent main body is a solid structure.
The shape of the upper combination body or the lower combination body can be changed according to requirements, and the upper combination body or the lower combination body can be the same as or different from the shape of the bracket main body and can be circular, rectangular or other shapes. In practical application, the shape of the upper combined body or the lower combined body matched with the shape of the contact part of the bone repair bracket and the surrounding bone can be designed and manufactured.
The thickness of the upper combination body or the lower combination body is 100 micrometers-5 millimeters.
The inner part of the upper combination body or the lower combination body is of a porous structure or a solid structure, the bioactive material part is of a porous structure, the porosity of the bioactive material part is 40% -80%, the pore diameter is 100-1500 microns, and the hydrogel is filled in the pore channels in the bioactive material.
The hydrogel can be on the surface of the bioactive material, and can also be filled in the pore channels of the bioactive material.
The hydrogel can be a hydrogel with photosensitive crosslinking property or a hydrogel with chemical crosslinking property.
The bone repair support has good mechanical property and biological activity, in the early stage of bone repair, an upper combination body and a lower combination body of the bone repair support are respectively contacted with surrounding bones of a bone defect part to quickly form stable and firm binding force, so that the bone repair support is stably fixed on the bone defect part, and meanwhile, along with the increase of implantation time, a plurality of new bone tissues grow into the main body part of the bone repair support to further fix the bone repair support, so that the bone repair support has better bone repair performance.
As shown in fig. 1, is a schematic flow chart of a manufacturing method of the high-strength bone repair scaffold of the present invention, and comprises the following steps:
1) selecting proper bioactive materials according to requirements, and designing a main structure, an upper combined body structure and a lower combined body structure of the bracket according to application occasions;
2) manufacturing a support blank by using a 3D printing technology or other manufacturing technologies;
3) placing the support blank into a high-temperature furnace for high-temperature sintering, and cooling to obtain a support;
4) mixing the upper combined body part of the scaffold with hydrogel to obtain a semi-finished scaffold;
5) and mixing the lower combined body part of the semi-finished scaffold with the hydrogel to obtain the high-strength bone repair scaffold.
When the bone repair stent is manufactured into a stent blank, the bioactive material parts of the stent main body, the upper combination body and the lower combination body are manufactured simultaneously.
Example 1
1) Selecting calcium magnesium silicate as a bioactive material, designing a cylindrical support main body structure by taking a large-section femoral bone defect as a model, and obtaining an upper combined body structure and a lower combined body structure, wherein the pore diameter of the support main body structure is 550 micrometers, the number of solid structures in the support main body is 3, and the pore diameter of the upper combined body structure and the pore diameter of the lower combined body structure are 550 micrometers;
2) manufacturing a bone repair support blank according to the designed model by using a 3D printing technology;
3) placing the bone repair scaffold blank in a high temperature furnace, 1150oC, calcining at high temperature for 3 hours, and cooling to obtain a support;
4) soaking the upper combined body part of the bracket in photosensitive hydrogel, then illuminating for a period of time, taking out the bracket, and then illuminating the upper combined body part for a period of time to finally obtain a semi-finished bracket with the upper combined body part in a solid structure;
5) and soaking the lower combined body part of the semi-finished bracket in photosensitive hydrogel, then illuminating for a period of time, taking out the semi-finished bracket, and then illuminating the lower combined body part for a period of time to finally obtain the high-strength bone repair bracket with the upper combined body part and the lower combined body part both having solid structures.
Example 2
1) Selecting calcium magnesium silicate as a bioactive material, designing a cylindrical support main body structure by taking a large-section femoral bone defect as a model, and obtaining an upper combined body structure and a lower combined body structure, wherein the pore diameter of the support main body structure is 500 micrometers, the number of solid structures in the support main body is 3, and the pore diameter of the upper combined body structure and the pore diameter of the lower combined body structure are 650 micrometers;
2) manufacturing a bone repair support blank according to the designed model by using a 3D printing technology;
3) placing the bone repair scaffold blank in a high temperature furnace, 1150oC, calcining at high temperature for 3 hours, and cooling to obtain a support;
4) soaking the upper combined body part of the bracket in photosensitive hydrogel for 1-100 seconds, then taking out the bracket, irradiating the upper combined body part for 1-10 seconds, soaking the upper combined body part of the bracket in the hydrogel for 1-100 seconds, then taking out the bracket, irradiating the upper combined body part for 1-10 seconds, repeating the steps for 5-7 times, and finally obtaining a semi-finished bracket with the upper combined body part of a porous structure;
5) soaking the lower combined body part of the semi-finished bracket in photosensitive hydrogel for 1-100 seconds, taking out the semi-finished bracket, irradiating the lower combined body part for 1-10 seconds, soaking the lower combined body part of the semi-finished bracket in the hydrogel for 1-100 seconds, taking out the semi-finished bracket, irradiating the lower combined body part for 1-10 seconds, repeating the steps for 5-7 times, and finally obtaining the high-strength bone repair bracket with the upper combined body part and the lower combined body part both having porous structures.
In practical applications, the shape of the upper combination body or the lower combination body is not necessarily the same as that of the bracket main body, and there are many cases, as shown in fig. 2, which are some common shape combination ways.
Fig. 2a shows that the shape of the upper and lower combined bodies 1 and 3 is the same as the shape of the holder body 2.
FIG. 2b shows that the upper and lower combined bodies are concentric and have a smaller shape than the main body of the stent.
In FIG. 2c, the shape of the upper assembly is smaller than that of the main body of the stand, and the shape of the lower assembly is the same as that of the main body of the stand.
In fig. 2d, the shape of the upper assembly is the same as that of the holder body, and the shape of the lower assembly is smaller than that of the holder body.
In FIG. 2e, the shape of the upper assembly is the same as that of the main body of the stand, and the shape of the lower assembly is smaller than that of the main body of the stand on one side.
In FIG. 2f, the shape of the upper assembly is smaller than that of the main body of the stand, and the shape of the lower assembly is the same as that of the main body of the stand on one side.
In FIG. 2g, the shape of the upper assembly is the same as that of the main body of the stand, the shape of the lower assembly is smaller than that of the main body of the stand, and the middle part of the lower assembly is missing.
In fig. 2h, the shape of the lower assembly is the same as that of the holder body, the shape of the upper assembly is smaller than that of the holder body, and the middle portion of the upper assembly is missing.
In fig. 2i, the shape of the upper assembly is the same as that of the main body of the stand, the shape of the lower assembly is smaller than that of the main body of the stand, and the lower assembly is formed by combining 2 blocks. Fig. 2i shows only one possibility, and it is also possible that the shape of the lower combination is the same as the shape of the main body of the bracket, the shape of the upper combination is smaller than the shape of the main body of the bracket, the upper combination is formed by combining 2 blocks, and the shape, structure and position of the 2 upper combinations can be changed.
In fig. 2j, the shape of the upper assembly is the same as that of the holder body, and the shape of the lower assembly is smaller than that of the holder body, and the assemblies are combined by 3 pieces having the same shape. Fig. 2j shows only one possibility, and it is also possible that the shape of the lower combination is the same as the shape of the main body of the bracket, the shape of the upper combination is smaller than the shape of the main body of the bracket, the upper combination is formed by combining 3 blocks, and the shape, structure and position of the 3 upper combinations can be changed.
Fig. 2 is only typical, the invention is not entirely exemplary, and forms other than fig. 2 are also possible.
In practical applications, in order to make the bone repair scaffold have high mechanical strength, the pore size, porosity and solid structure size inside the scaffold body can be changed, as shown in fig. 3, which are several common ways.
Fig. 3a is a schematic view of a solid structure in 2 pieces in a stent body.
Fig. 3b is a schematic view of the solid structure in the stent body being a hollow ring.
Fig. 3c is a schematic structural view of the stent body with a solid structure inside.
Claims (8)
1. A high-strength bone repair support is characterized by comprising 3 parts, namely an upper combined body, a support main body and a lower combined body;
the lower surface of the upper combined body is contacted with the upper surface of the bracket main body, and the lower surface of the bracket main body is contacted with the upper surface of the lower combined body;
the stent main body is made of bioactive materials and has high mechanical strength;
the bioactive material is calcium magnesium silicate, phosphate, silicate or a mixture thereof;
the upper combination body and the lower combination body are both a mixture of bioactive materials and hydrogel;
in the early stage of bone repair, the upper combination body and the lower combination body of the bone repair support are respectively contacted with surrounding bones of a bone defect part to quickly form stable and firm binding force, so that the bone repair support is stably fixed on the bone defect part, and meanwhile, along with the increase of implantation time, a plurality of new bone tissues grow into the support main body part of the bone repair support to further fix the bone repair support, so that the bone repair support has better bone repair performance.
2. The high-strength bone repair scaffold as claimed in claim 1, wherein the scaffold body is a composite of a porous structure and a solid structure, the porous structure is distributed at the periphery and inside, the pore diameter is 100-600 μm, the porosity is 30-80%, and a plurality of solid structures are uniformly distributed in the middle, and the number of the solid structures is 3, 4 or 6.
3. The high strength bone repair scaffold according to claim 1, wherein the solid structure of said scaffold body has a size of 300 μm to 5 mm in thickness.
4. The high-strength bone repair scaffold according to claim 1, wherein the shape of the upper or lower combined body is changed as required, and is the same as the shape of the scaffold body or is circular or rectangular.
5. The high strength bone repair scaffold according to claim 1, wherein the thickness of said upper or lower binder is 100 μm to 5 mm.
6. The high-strength bone repair scaffold according to claim 1, wherein the interior of the upper or lower combination body is a porous structure or a solid structure, the bioactive material portion is a porous structure with a porosity of 40% -80%, the pore size is 100-1500 μm, and the hydrogel is filled in the pores inside the bioactive material.
7. The high-strength bone repair scaffold according to claim 1, wherein the hydrogel in the upper or lower binder is a photo-crosslinking hydrogel or a chemical crosslinking hydrogel.
8. A method of manufacturing a high strength bone repair scaffold according to claim 1, comprising the steps of:
1) selecting proper bioactive materials according to requirements, and designing a main structure, an upper combined body structure and a lower combined body structure of the bracket according to application occasions;
2) manufacturing a support blank by using a 3D printing technology or other manufacturing technologies;
3) placing the support blank into a high-temperature furnace for high-temperature sintering, and cooling to obtain a support;
4) mixing the upper combined body part of the scaffold with hydrogel to obtain a semi-finished scaffold;
5) and mixing the lower combined body part of the semi-finished scaffold with the hydrogel to obtain the high-strength bone repair scaffold.
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| CN105194728A (en) * | 2015-10-12 | 2015-12-30 | 浙江大学 | Degradable bioactive porous ceramic material, preparation method and application of degradable bioactive porous ceramic material |
| CN105769382A (en) * | 2016-02-24 | 2016-07-20 | 浙江大学 | Biological active porous structure support suitable for bone regeneration and repair and manufacturing method thereof |
| CN109876184A (en) * | 2019-02-28 | 2019-06-14 | 广州迈普再生医学科技股份有限公司 | A kind of elasticity can deformation skull-base defects recovery support and preparation method thereof |
| CN111214698A (en) * | 2020-01-22 | 2020-06-02 | 潍坊医学院附属医院 | Composite bone repair material and preparation method thereof |
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| CN105194728A (en) * | 2015-10-12 | 2015-12-30 | 浙江大学 | Degradable bioactive porous ceramic material, preparation method and application of degradable bioactive porous ceramic material |
| CN105769382A (en) * | 2016-02-24 | 2016-07-20 | 浙江大学 | Biological active porous structure support suitable for bone regeneration and repair and manufacturing method thereof |
| CN109876184A (en) * | 2019-02-28 | 2019-06-14 | 广州迈普再生医学科技股份有限公司 | A kind of elasticity can deformation skull-base defects recovery support and preparation method thereof |
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