CN112587281A - Hand-held type skin normal position printing oxidation curing device - Google Patents
Hand-held type skin normal position printing oxidation curing device Download PDFInfo
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- CN112587281A CN112587281A CN202011555533.8A CN202011555533A CN112587281A CN 112587281 A CN112587281 A CN 112587281A CN 202011555533 A CN202011555533 A CN 202011555533A CN 112587281 A CN112587281 A CN 112587281A
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- biological ink
- printing
- ink chamber
- curing device
- nozzle
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- 238000007639 printing Methods 0.000 title claims abstract description 44
- 230000003647 oxidation Effects 0.000 title abstract description 12
- 238000007254 oxidation reaction Methods 0.000 title abstract description 12
- 238000001125 extrusion Methods 0.000 claims abstract description 21
- 238000011065 in-situ storage Methods 0.000 claims abstract description 16
- 239000000463 material Substances 0.000 claims abstract description 13
- 238000007789 sealing Methods 0.000 claims abstract description 5
- 230000001590 oxidative effect Effects 0.000 claims description 15
- 239000011521 glass Substances 0.000 claims description 4
- 229910001220 stainless steel Inorganic materials 0.000 claims description 4
- 239000010935 stainless steel Substances 0.000 claims description 4
- 238000005260 corrosion Methods 0.000 claims description 3
- 239000011347 resin Substances 0.000 claims description 3
- 229920005989 resin Polymers 0.000 claims description 3
- 239000000919 ceramic Substances 0.000 claims description 2
- 229910052751 metal Inorganic materials 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 239000000017 hydrogel Substances 0.000 abstract description 12
- 239000002243 precursor Substances 0.000 abstract description 8
- 238000000034 method Methods 0.000 abstract description 7
- 239000000203 mixture Substances 0.000 abstract description 2
- 206010052428 Wound Diseases 0.000 description 6
- 208000027418 Wounds and injury Diseases 0.000 description 6
- JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 description 6
- 239000007800 oxidant agent Substances 0.000 description 5
- 206010072170 Skin wound Diseases 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 238000010146 3D printing Methods 0.000 description 2
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- UMGDCJDMYOKAJW-UHFFFAOYSA-N aminothiocarboxamide Natural products NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 238000010017 direct printing Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 230000001991 pathophysiological effect Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/10—Hair or skin implants
- A61F2/105—Skin implants, e.g. artificial skin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y30/00—Apparatus for additive manufacturing; Details thereof or accessories therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y40/00—Auxiliary operations or equipment, e.g. for material handling
- B33Y40/20—Post-treatment, e.g. curing, coating or polishing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y70/00—Materials specially adapted for additive manufacturing
- B33Y70/10—Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
- A61F2240/002—Designing or making customized prostheses
Abstract
A hand-held skin in-situ printing oxidation curing device comprises a biological ink box, a collinear extrusion nozzle and a printing nozzle, wherein a plurality of biological ink chambers are arranged in the biological ink box; a movable rubber plug is arranged in the tail part of the biological ink chamber, a sealing gasket is arranged at the same time to ensure the air tightness of the biological ink chamber, and the tail part is connected with a gas pipeline; the extrusion speed of each biological ink chamber material is independently controlled by an external air pressure driving device. The device has simple structure, is suitable for being held by hands and is suitable for aseptic operation. The device can mix hydrogel precursor solution through collineation extrusion nozzle, through the speed that air pressure device control was mixed, carries out the oxidation curing through printing the shower nozzle, and the controllable easy operation of process.
Description
Technical Field
The invention belongs to the field of 3D printing devices, and particularly relates to a handheld skin in-situ printing oxidation curing device.
Background
Due to the pathophysiological complexity of the wound healing process, ideal tissue regeneration is difficult to achieve. In recent decades, natural and artificial skin grafts have been used primarily for healing wounds. However, most of them are expensive and the cost of post-care is high. The hydrogel has the characteristics of injectability, wound filling, wound moisture retention, drug delivery and the like, and has become a research hotspot of wound healing. Particularly, with the rise of 3D printing technology, the combination of hydrogel and a bioprinter can directly construct bionic tissues to replace skin tissues in vitro according to the size and shape of wounds, the method can accelerate repair, but a large amount of hardware is needed to enter an operating room, equipment needs to be disinfected before use, and a large amount of manpower and material resources are consumed. In addition, the hydrogel precursor solution contains catechol Cat group and thiourea NCSN group, and needs to be oxidized and cured by spraying strong oxidant sodium periodate; the uniformly mixed hydrogel precursor solution needs to be added step by step in the oxidation curing process, and meanwhile, a strong oxidant is dripped on the top of the hydrogel precursor solution, so that the operation process is complex, and the state of a hydrogel finished product is influenced due to improper operation. In addition, as described in CN 106891527 a, the bio-ink chamber needs to be thoroughly cleaned and dried before being used next time, which is a cumbersome operation. Therefore, there is a need to develop a printing and curing device which is suitable for clinical operation, has a small volume and a simple structure, can be disassembled and replaced in a biological ink chamber, and can solve the problem of hydrogel oxidation and curing.
Disclosure of Invention
The invention aims to provide a handheld skin in-situ printing, oxidizing and curing device, which is used for controlling the release speed of a hydrogel precursor in a biological ink chamber and the spraying speed of an oxidant in the biological ink chamber by externally connecting an air pressure driving device at a wound so as to solve the problems of in-situ direct printing on the damaged wound skin and realization of oxidation and fixation.
In order to solve the technical problems, the invention provides a specific technical scheme of a handheld skin printing and curing device for a laboratory, which comprises the following steps:
a hand-held skin in-situ printing oxidation curing device comprises a biological ink box, a collinear extrusion nozzle and a printing nozzle, wherein three biological ink chambers are arranged in the biological ink box; the head parts of two adjacent biological ink chambers are connected with a collinear extrusion nozzle through threads, and the tail parts of the two adjacent biological ink chambers are connected with a gas pipeline; the head of the third biological ink chamber is connected with the printing nozzle through threads, the tail of the third biological ink chamber is connected with the gas pipeline, and the extrusion speed of each biological ink chamber material is independently controlled through the air pressure driving device, so that the printing material is rapidly solidified.
A movable rubber plug is arranged in the biological ink chamber, the outflow speed of the biological ink hydrogel precursor solution and the oxidant can be controlled through the air pressure driving device, and the biological ink hydrogel precursor solution is mixed at the collinear extrusion nozzle and is extruded to eject mixed liquid.
The joint of the tail part of the biological ink chamber and the gas pipeline is provided with a sealing gasket with the circular diameter of 7-12 mm so as to ensure the air tightness of the biological ink chamber.
The collinear extrusion nozzle is provided with internal threads, and the head part of the biological ink chamber is provided with a thread section which can be tightly connected with each other through the threads.
The printing nozzle is provided with internal threads, the head part of the biological ink chamber is provided with a thread section, and the biological ink chamber can be tightly connected through the threads.
The biological ink box is a hollow transparent cuboid, the length, width and height are 150 and 200 mm, 45-55 mm, 15-20 mm, the upper angle, the lower angle, the left angle and the right angle are designed by fillets, and the size and the shape are convenient for holding by hands.
The shape of the biological ink box is triangular, square and other shapes.
The biological ink chamber is a hollow transparent cylinder with the diameter of 9-15 mm 150-200 mm.
The biological ink chamber is a replaceable ink chamber, and different biological ink materials can be replaced in the actual use process.
The biological ink chamber is made of resin materials or glass materials and has an anti-corrosion effect.
The biological ink chamber is provided with scale marks.
The collinear extrusion nozzle is made of glass, ceramics, metal or high polymer.
The external diameter of the printing nozzle thread is 9-15 mm, and the internal diameter is 7-12 mm.
The printing nozzle is made of stainless steel and is provided with anti-skid threads.
The printing nozzle can bear pressure of 0-12 MPa, and the oxidant is in a hollow conical atomization state through the nozzle.
The handheld skin printing and curing device for the laboratory has the following advantages:
(1) the device can be used manually, has a small and flexible structure, is convenient for sterile operation, and is very suitable for clinical operation of skin wound surfaces;
(2) the device can mix the hydrogel precursor solution through the collinear extrusion nozzle, control the mixing speed through the air pressure device, and carry out oxidation curing through the printing nozzle, and the process is controllable and simple to operate;
(3) the biological ink chamber in the device can be detached and replaced, the biological ink is not required to be added after the biological ink chamber is cleaned and dried, and the operation is simple and convenient.
Drawings
FIG. 1 is a schematic diagram and a partial enlarged view of a hand-held skin printing and curing device for a laboratory according to the present invention;
FIG. 2 is a schematic top view of a hand-held apparatus for printing and curing skin in laboratory according to the present invention;
FIG. 3 is a schematic cross-sectional view of a collinear extrusion nozzle;
FIG. 4 is a schematic top view of a collinear extrusion nozzle.
Description of reference numerals: 1. biological ink box, 2, collineation extrusion nozzle, 3, print the shower nozzle, 4, biological ink chamber, 5, sealed pad, 6, portable rubber buffer, 7, scale mark.
Detailed Description
In order to better understand the purpose, structure and function of the present invention, a hand-held skin-printing and curing device for laboratory use according to the present invention will be described in detail with reference to the accompanying drawings.
Referring to the drawings, fig. 1 is a schematic structural diagram and a partial enlarged view of a handheld skin printing and curing device for a laboratory according to the present invention. A hand-held skin in-situ printing oxidation curing device consists of a biological ink box (1), a collinear extrusion nozzle (2) and a printing nozzle (3), wherein the biological ink box (1) is internally provided with three biological ink chambers (4); wherein the head parts of two adjacent biological ink chambers (4) are connected with the collinear extrusion nozzle (2) through threads, and the tail parts are connected with the gas pipeline; the head of the third biological ink chamber (4) is connected with the printing spray head (3) through threads, the tail of the third biological ink chamber is connected with the gas pipeline, all the biological ink chambers (4) are internally provided with movable rubber plugs (6), and a sealing gasket (5) is arranged at the joint of the tail of the biological ink chamber (4) and the gas pipeline to ensure the air tightness of the biological ink chamber (4); the collinear extrusion nozzle (2) is made of stainless steel, is oval and is provided with internal threads, the head part of the biological ink chamber (4) is provided with external threads, the biological ink chamber and the biological ink chamber can be tightly connected through the threads and can be connected with the two biological ink chambers (4); the printing nozzle (3) is designed in a conical shape and made of stainless steel, anti-skid threads are designed on the outer part of the printing nozzle, internal threads are arranged in the printing nozzle, external threads are arranged at the head part of the biological ink chamber (4), and the printing nozzle and the biological ink chamber can be tightly connected through the threads; the biological ink box (4) is made of transparent plastic and is a hollow transparent cuboid, the length, the width and the height are 200 mm, 55 mm and 20 mm, and the upper corner, the lower corner, the left corner and the right corner are designed by rounding corners. The biological ink chamber (4) is made of resin materials, scales (7) are arranged outside the biological ink chamber, the biological ink chamber is suitable for various biological ink materials, and the biological ink chamber has an anti-corrosion effect.
Human collagen-benzoquinone, human collagen-thiourea and sodium periodate with determined concentration and proper molar ratio are added from the tail of the biological ink chamber; the sealing pad and the movable rubber plug are sequentially arranged in the biological ink chamber and plugged. With laboratory hand-held type skin print solidification equipment, arrange impaired skin upside in, through atmospheric pressure drive arrangement control people collagen-benzoquinone, people collagen-thiourea release rate, both go out the homogeneous mixing at collineation extrusion nozzle (2), the rethread atmospheric pressure control sodium periodate goes out from thread printing shower nozzle (3) and sprays, evenly sprinkles in mixing in aquogel mixed liquid top, waits for 60S to accomplish the oxidation fixed.
The device realizes the in-situ fixation of skin wounds and damaged parts, avoids the error operation of manual direct addition, has the advantages of manual use, small and exquisite structure, simple and flexible operation, and can be widely applied to experimental operation and skin wound surface clinical operation.
It is to be understood that the present invention has been described with reference to certain embodiments, and that various changes in the features and embodiments, or equivalent substitutions may be made therein by those skilled in the art without departing from the spirit and scope of the invention. In addition, many modifications may be made to adapt a particular situation or material to the teachings of the invention without departing from the essential scope thereof. Therefore, it is intended that the invention not be limited to the particular embodiment disclosed, but that the invention will include all embodiments falling within the scope of the appended claims.
Claims (9)
1. A hand-held skin in-situ printing, oxidizing and curing device comprises a biological ink box (1), a collinear extrusion nozzle (2) and a printing nozzle (3).
2. The handheld skin in-situ printing, oxidizing and curing device according to claim 1, wherein a plurality of biological ink chambers (4) are arranged in the biological ink cartridge, a movable rubber plug (6) is arranged in the tail of each biological ink chamber (4), a sealing gasket (5) is arranged to ensure the air tightness of each biological ink chamber (4), and the tail of each biological ink chamber is connected with a gas pipeline; the extrusion speed of each biological ink chamber material is independently controlled by an external air pressure driving device;
the collinear extrusion nozzle (2) is provided with internal threads, and the head of the biological ink chamber (4) is provided with an external thread section which can be tightly connected with each other through threads;
the printing nozzle (3) is provided with internal threads, the head of the biological ink chamber (4) is provided with an external thread section, and the external thread section and the biological ink chamber can be tightly connected through threads.
3. The handheld skin in-situ printing, oxidizing and curing device as claimed in claim 1, wherein the biological ink cartridge (1) is a hollow transparent cuboid with a length, a width and a height of 150-.
4. The handheld skin in-situ printing, oxidizing and curing device as claimed in claim 1 or 2, wherein the shape of the bio-ink cartridge (1) can be triangular or square.
5. The handheld skin in-situ printing, oxidizing and curing device as claimed in claim 1, wherein the bio-ink chamber (4) is a hollow transparent cylinder with a diameter of 9-15 mm and a length of 150 mm and 200 mm.
6. The handheld skin in-situ printing, oxidizing and curing device according to claim 1, wherein the bio-ink chamber (4) is made of resin material or glass material and has an anti-corrosion function.
7. The handheld skin in-situ printing, oxidizing and curing device according to claim 1, wherein the collinear extrusion nozzle (2) is made of one of glass, ceramic, metal or polymer.
8. The handheld skin in-situ printing, oxidizing and curing device as claimed in claim 1, wherein the thread of the printing nozzle (3) has an outer diameter of 9-15 mm and an inner diameter of 7-12 mm.
9. The handheld skin in-situ printing, oxidizing and curing device according to claim 1, wherein the printing nozzle (3) is made of stainless steel and is provided with anti-skid threads.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011555533.8A CN112587281A (en) | 2020-12-25 | 2020-12-25 | Hand-held type skin normal position printing oxidation curing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011555533.8A CN112587281A (en) | 2020-12-25 | 2020-12-25 | Hand-held type skin normal position printing oxidation curing device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112587281A true CN112587281A (en) | 2021-04-02 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011555533.8A Pending CN112587281A (en) | 2020-12-25 | 2020-12-25 | Hand-held type skin normal position printing oxidation curing device |
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| Country | Link |
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| CN (1) | CN112587281A (en) |
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| CN109776451A (en) * | 2017-11-15 | 2019-05-21 | 中山光禾医疗科技有限公司 | Preparation, raw material, product and the application of photocrosslinkable hydrogel material |
| CN109922755A (en) * | 2016-10-07 | 2019-06-21 | 多伦多大学管理委员会 | Organize printer |
| CN110481023A (en) * | 2019-08-22 | 2019-11-22 | 中国矿业大学 | The 3D biometric print nozzle of three holes one and its method for preparing multilayer gel |
-
2020
- 2020-12-25 CN CN202011555533.8A patent/CN112587281A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000015117A1 (en) * | 1998-09-17 | 2000-03-23 | Focal, Inc. | Self-cleaning fluid delivery device for medical applications |
| US20040059283A1 (en) * | 2002-09-20 | 2004-03-25 | Kirwan John M. | Multi-pressure biocompatible agent delivery device and method |
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