CN112577791A

CN112577791A - Sample analysis system and method of controlling sample analysis system

Info

Publication number: CN112577791A
Application number: CN201910924184.3A
Authority: CN
Inventors: 甘裕明; 王鑫润
Original assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Current assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Priority date: 2019-09-27
Filing date: 2019-09-27
Publication date: 2021-03-30

Abstract

The invention provides a sample analysis system and a method for controlling the same, wherein the sample analysis system comprises: the centrifugal modules are used for carrying out centrifugal operation on a sample to be detected; a plurality of rails respectively connected to the centrifugal modules; the dispatching device is used for dispatching the sample to be tested to the corresponding centrifugal module through the track so as to carry out centrifugal operation; a controller for setting centrifugation times of the respective centrifugation modules based on a test item of the sample to be tested. According to the sample analysis system and the method for controlling the sample analysis system, the centrifugation time of the centrifugation module is set according to the test item type of the sample to be tested, so that the centrifugation time redundancy can be effectively reduced, the centrifugation efficiency is improved, and the TAT time of the system is reduced.

Description

Sample analysis system and method of controlling sample analysis system

Technical Field

The present invention relates to a sample analysis system, and more particularly, to a sample analysis system and a method of controlling a sample analysis system.

Background

In the field of medical testing, prior to analysis of a sample to be tested, a centrifugation operation is usually performed to separate the components of the sample. In current TLA (total laboratory automation) systems, the working process of the centrifugation operation is typically: and placing the sample to be tested on the centrifugal frame by the manipulator, placing the centrifugal frame into a centrifugal machine after the centrifugal frame is fully loaded, starting centrifugation, and returning the centrifuged sample to the main track by the manipulator after centrifuging for a fixed time so as to finish the centrifugation process. In order to centrifuge all samples sufficiently, the centrifugation time is usually set to be long, so that even if the centrifugation time required for the samples is short, the samples must not stay in the centrifuge for a long time, resulting in low centrifugation efficiency.

In addition, current TLA systems do not distinguish between sample test item types, all samples are scheduled to the same centrifuge module, also creating practical centrifugation time redundancy of samples, resulting in inefficient centrifugation.

Therefore, there is a need in the art for a new sample analysis system, apparatus and method of controlling a sample analysis system to solve the above-mentioned problems.

Disclosure of Invention

The present invention has been made to solve the above problems. According to an aspect of the present invention, there is provided a sample analysis system comprising: the centrifugal modules are used for carrying out centrifugal operation on a sample to be detected; a plurality of rails respectively connected to the centrifugal modules; the dispatching device is used for dispatching the sample to be tested to the corresponding centrifugal module through the track so as to carry out centrifugal operation; a controller for setting centrifugation times of the respective centrifugation modules based on a test item of the sample to be tested.

In one embodiment, the controller is further configured to: and when the sample to be detected reaches the centrifugal module, acquiring the centrifugal time required by the sample of the sample to be detected, and setting the centrifugal time of the centrifugal module as the longest centrifugal time in the centrifugal time required by the sample of each sample to be detected.

In one embodiment, the centrifugation time required for the sample of the sample to be tested is preset based on the centrifugation time required for each test item of the sample to be tested.

In one embodiment, the centrifugation time required for the sample of the sample to be tested is preset as the longest centrifugation time among the centrifugation times required for the respective test items of the sample to be tested.

According to still another aspect of the present invention, there is provided a sample analysis system including: the centrifugal modules are used for carrying out centrifugal operation on a sample to be detected; a plurality of rails respectively connected to the centrifugal modules; the dispatching device is used for dispatching the sample to be tested to the corresponding centrifugal module through the track so as to carry out centrifugal operation; a controller for setting centrifugation times of the respective centrifugation modules based on the different time periods.

According to yet another aspect of the present invention, there is provided a sample analysis system comprising: the centrifugal modules are used for carrying out centrifugal operation on a sample to be detected; a plurality of rails respectively connected to the centrifugal modules; the dispatching device is used for dispatching the sample to be tested to the corresponding centrifugal module through the track so as to carry out centrifugal operation; a controller for setting the centrifugation time of each centrifugation module based on the customized sample type of the sample to be tested.

In one embodiment, wherein the customized sample type comprises a test item type, wherein the controller is further configured to set a centrifugation time for each centrifugation module based on the test item type of the sample under test.

In one embodiment, wherein the controller is further configured to: determining to which centrifugal module the sample to be tested is scheduled based on a first determination condition, wherein the first determination condition includes whether a required centrifugation time of the sample to be tested is less than or equal to a centrifugation time of at least one centrifugal module of the plurality of centrifugal modules.

In one embodiment, the controller is further configured to: when the centrifugal time required by the sample of the sample to be detected is less than or equal to the centrifugal time of at least one centrifugal module in the plurality of centrifugal modules, controlling the scheduling device to schedule the sample to be detected to the centrifugal module with the centrifugal time having the smallest difference with the centrifugal time required by the sample of the sample to be detected in the at least one centrifugal module.

In one embodiment, the controller is further configured to: and when the centrifugal time required by the sample of the sample to be detected is greater than the centrifugal time of all the centrifugal modules and no centrifugal module without the sample exists, controlling the scheduling device to schedule the sample to be detected to the centrifugal module with the centrifugal time having the smallest difference with the centrifugal time required by the sample of the sample to be detected in the plurality of centrifugal modules.

In one embodiment, the controller is further configured to: when the centrifugal time required by the sample of the sample to be detected is greater than the centrifugal time of all the centrifugal modules and at least one centrifugal module without the sample exists, determining which centrifugal module the sample to be detected is dispatched to based on a second judgment condition, wherein the second judgment condition comprises whether the centrifugal time required by the sample of the sample to be detected is less than or equal to a preset judgment threshold value of any centrifugal module in the centrifugal modules without the sample.

In one embodiment, the controller is further configured to: and when the centrifugal time required by the sample of the sample to be detected is less than or equal to the judgment threshold of all centrifugal modules without the sample, controlling the scheduling device to schedule the sample to be detected to the centrifugal module with the centrifugal time having the smallest difference with the centrifugal time required by the sample of the sample to be detected.

In one embodiment, the controller is further configured to: when the centrifugal time required by the sample of the sample to be detected is larger than the judgment threshold value of at least one centrifugal module in the sample-free centrifugal modules, controlling the dispatching device to dispatch the sample to be detected to the centrifugal module with the smallest difference between the judgment threshold value of the sample to be detected and the centrifugal time required by the sample of the sample to be detected in the sample-free centrifugal modules.

In one embodiment, the first determination condition can be set to be enabled or disabled based on different time periods.

In one embodiment, wherein the customized sample type comprises a time period sample type, wherein the controller is further configured to set centrifugation times for individual centrifugation modules based on different time periods.

In one embodiment, wherein the customized sample type comprises a sample source type, wherein the controller is further configured to set a centrifugation time for each centrifugation module based on the different sample sources.

In one embodiment, the controller is further configured to: and when the sample to be detected reaches the centrifugal module, acquiring the required centrifugal time of the sample to be detected, and setting the centrifugal time of the centrifugal module as the longest centrifugal time in the required centrifugal time of the sample of each sample to be detected reaching the centrifugal module.

In one embodiment, the centrifugation time required for the sample is preset based on the centrifugation time required for each test item of the sample to be tested.

In one embodiment, the centrifugation time required for the sample is preset to be the longest centrifugation time among the centrifugation times required for the respective test items of the sample to be tested.

According to yet another aspect of the present invention, there is provided a method for controlling a sample analysis system under test, the sample analysis system under test comprising a plurality of centrifuge modules, the method comprising: acquiring the centrifugal time required by a sample of a sample to be tested reaching the centrifugal module, wherein the centrifugal time required by the sample of the sample to be tested is preset as the longest centrifugal time in the centrifugal time required by each test item of the sample to be tested; and setting the centrifugation time of the centrifugation module as the longest centrifugation time in the centrifugation time needed by the sample of each sample to be tested.

According to a further aspect of the invention, a computer-readable medium is provided, on which a computer program is stored, which computer program, when executed, performs the method as described above.

According to the sample analysis system and the method for controlling the sample analysis system, provided by the embodiment of the invention, the centrifugation time of the centrifugation module is set according to the test item type of the sample to be tested, so that the centrifugation time redundancy can be effectively reduced, the centrifugation efficiency is improved, and the TAT time of the system is reduced.

Drawings

The above and other objects, features and advantages of the present invention will become more apparent by describing in more detail embodiments of the present invention with reference to the attached drawings. The accompanying drawings are included to provide a further understanding of the embodiments of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention. In the drawings, like reference numbers generally represent like parts or steps.

FIG. 1 shows a schematic structural diagram of a sample analysis system according to one embodiment of the present invention;

FIG. 2 shows a schematic structural diagram of a sample analysis system according to another embodiment of the present invention;

FIG. 3 is a schematic diagram of a preprocessing module according to one embodiment of the invention;

FIG. 4 is a schematic structural diagram of an aftertreatment module according to one embodiment of the invention;

FIG. 5 is a block diagram of a looped track pipelining system according to one embodiment of the present invention;

FIG. 6 shows a flow chart of steps of a method for controlling a sample analysis system according to one embodiment of the invention;

FIG. 7 illustrates an exemplary display interface of a display module according to one embodiment of the invention.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, exemplary embodiments according to the present invention will be described in detail below with reference to the accompanying drawings. It is to be understood that the described embodiments are merely a subset of embodiments of the invention and not all embodiments of the invention, with the understanding that the invention is not limited to the example embodiments described herein. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the invention described herein without inventive step, shall fall within the scope of protection of the invention.

As described above, the centrifugation time of the current centrifugation module is fixed, resulting in low centrifugation efficiency, and all samples are scheduled to the same centrifugation module, resulting in low centrifugation efficiency.

In order to improve the centrifugation efficiency of the centrifuge modules, the present invention provides a sample analysis system, wherein the centrifugation time of each centrifuge module is set based on the test item of the sample to be tested, i.e., the centrifugation time of each centrifuge module is set based on the centrifugation time required for the test item of the sample to be tested, which can reduce the centrifugation time redundancy of the sample to be tested in the centrifuge modules, thereby reducing the TAT (total analysis time, i.e., the total time required from the receipt of the sample to the completion of the analysis of the sample) time of the sample to be tested, and improving the centrifugation efficiency.

In order to improve the centrifugation efficiency of the centrifuge modules, the invention also provides a sample analysis system, wherein the centrifugation time of each centrifuge module is set based on different time periods, namely the centrifugation time of each centrifuge module is set based on a peak time period and an off-peak time period, so that the TAT time of a sample to be measured is reduced, and the centrifugation efficiency is improved.

In order to improve the centrifugation efficiency of the centrifugation modules, the invention further provides a sample analysis system, wherein the centrifugation time of each centrifugation module is set based on the customized sample type of the sample to be tested, wherein the customized sample type can comprise the test item type, different time periods, sample source type and the like of the sample to be tested, and can be added or deleted by a person skilled in the art as required. The centrifugation time of each centrifugation module is set based on the self-defined sample type, the sample type can be added or deleted according to the user requirement, the TAT time of the sample to be detected is reduced to the maximum extent, and the centrifugation efficiency is improved.

In order to improve the centrifugation efficiency of the centrifugation module, the invention also provides a sample analysis system, wherein the determination of which centrifugation module to dispatch the sample to be tested is based on whether the required centrifugation time of the sample to be tested is less than or equal to the centrifugation time of at least one centrifugation module in the plurality of centrifugation modules. The scheduling strategy can schedule the samples to the proper centrifugal module to the maximum extent, so that the centrifugal efficiency is improved.

The present invention relates to a centrifugal or flow line system for centrifugal or analysis of sample, and is characterized by that the single-machine form of said invented equipment also can be used for making cascade or flow line system, and said cascade or flow line system is formed from several single-machine form instruments, and all the single-machines are connected together by means of track, when the instruments on the cascade or flow line system are separated from the line, they are changed into off-line form, so that the off-line instruments are changed into independent single-machines.

Example one

As shown in fig. 1, fig. 1 shows a schematic structural diagram of a sample analysis system according to an embodiment of the present invention.

Referring to fig. 1, the sample analysis system according to the present embodiment may include a plurality of centrifuge modules 100, a plurality of tracks 110, a scheduling device 120, and a controller 130. The centrifugal module 100 is used for performing centrifugal operation on a sample to be detected; a plurality of rails 110 are respectively connected to the respective centrifuge modules 100; the dispatching device 120 is used for dispatching the samples to be tested to the corresponding centrifuge modules 100 through the plurality of tracks 110 for centrifugation. In one embodiment, the sample to be tested may include any suitable sample that can be tested in the medical field, such as a blood sample, a urine sample, and the like, but the invention is not limited thereto. Fig. 1 shows an example of three centrifuge modules 100, which are for illustrative purposes only and are not intended to limit the number of centrifuge modules. In some examples, other modules (e.g., analysis modules, etc.) and components for pre-processing and post-processing may be added to the sample analysis system, which may also be referred to as a pipeline system.

Wherein the controller 130 is configured to set the centrifugation time of each centrifugation module based on the test item of the sample to be tested. Because the centrifugal time required by each test item of the sample to be tested is different, and the centrifugal time required by each sample to be tested is different, the centrifugal time of the centrifugal module is reasonably set based on the test item of the sample, the redundant phenomenon of the centrifugal time can be reduced to the greatest extent, and the centrifugal efficiency of the centrifugal module is improved.

In one embodiment, the test items of the sample may include immunological test items and biochemical test items. In one embodiment, the test items of the sample may include albumin, total protein, total bilirubin, free thyroxine, thyroglobulin, trans-T3, and the like.

In one embodiment, the controller 130 is further configured to: when a sample to be measured reaches the centrifugal module 100, the centrifugation time required for the sample of the sample to be measured is obtained, and the centrifugation time of the centrifugal module 100 is set as the longest centrifugation time among the centrifugation times required for the samples of the respective samples to be measured. Specifically, the setting process may be: when the first sample 1 to be tested reaches the centrifugation module 100, the centrifugation module 100 obtains the centrifugation time (for example, 200 seconds) required for the sample of the sample 1 to be tested, and the controller 130 controls to set the centrifugation time of the centrifugation module to 200 seconds; when the second sample 2 reaches the centrifugation module, the centrifugation module 100 obtains the centrifugation time (for example, 300 seconds) required for the sample of the sample 2, and since 300 seconds is greater than the current centrifugation time 200 seconds of the centrifugation module 100, the controller 130 controls to set the centrifugation time of the centrifugation module 100 to 300 seconds; when the third sample 3 to be tested reaches the centrifugation module, the centrifugation module 100 obtains the centrifugation time (for example, 250 seconds) required for the sample of the sample 3 to be tested, and since 250 seconds is less than the current centrifugation time of 300 seconds of the centrifugation module 100, the controller 130 controls not to change the centrifugation time of the centrifugation module 100, that is, the centrifugation time is kept at 300 seconds, and so on. In the embodiment, the centrifugal time of the centrifugal module is adjusted in real time along with the arrival of the sample to be detected, so that the centrifugal time of the centrifugal module can meet the centrifugal time requirements of all samples, and the centrifugal time redundancy is avoided, so that the centrifugal efficiency of the centrifugal module is improved, and the TAT time of the whole sample analysis system is shortened.

In one embodiment, the centrifugation time required for the sample of the sample to be tested is preset based on the centrifugation time required for each test item of the sample to be tested. In one embodiment, the centrifugation time required for the sample of the sample to be tested is preset as the longest centrifugation time among the centrifugation times required for the respective test items of the sample to be tested. Specifically, for example, if each test item of the sample 1 to be tested is albumin (required centrifugation time is 300 seconds), total protein (required centrifugation time is 250 seconds), prealbumin (required centrifugation time is 200 seconds), and total bilirubin (required centrifugation time is 310 seconds), the sample required centrifugation time of the sample 1 to be tested may be preset to be the longest centrifugation time among the required centrifugation times of all the test items, that is, the sample required centrifugation time of the sample 1 to be tested is 310 seconds. In the embodiment, the centrifugal time required by the samples is set according to different test items of different samples, so that the centrifugal time required by the samples of each sample is the shortest time meeting the centrifugal requirement of the sample, and the centrifugal time of the centrifugal module set according to the centrifugal time required by the samples is the shortest time meeting the centrifugal time requirements of all the samples, thereby improving the centrifugal efficiency of the centrifugal module and further shortening the TAT time of the whole sample analysis system.

In one embodiment, among other things, the centrifugation time required for each test item may be set manually by a user, or a default value may be employed by the sample analysis system.

In one embodiment, the sample analysis system may further include an input module and a display module (not shown). The input module may be used for a user to input commands, and typically may be a mouse, a keyboard, and the like. The display module is used for displaying contents, such as contents related to the centrifugation time setting of the centrifugation module.

Referring to fig. 7, fig. 7 illustrates an exemplary display interface of a display module according to an embodiment of the present invention, which shows an interface for setting centrifugation time required for a test item, including, as an example, a centrifugation time setting required for a biochemical test item and a centrifugation time setting required for an immunological test item. Wherein a user may select a certain test item through a mouse and thus input a corresponding centrifugation time through a keyboard. Biochemical test items and immunological test items are shown in fig. 7, it being understood that this is merely exemplary and that one skilled in the art may also add more test items or modify test items as desired.

Wherein, for each test item, the user can select a package name (e.g. liver function, blood lipid, cardiac muscle, etc.) through a pull-down list, and after selecting the package name, the test item corresponding to the package (e.g. albumin, total protein, prealbumin, total bilirubin, etc. corresponding to the liver function package) will be automatically displayed, and at this time, the user can set the centrifugation time corresponding to each test item. In one embodiment, the centrifugation time may be manually entered by a user. In another embodiment, the centrifugation time may be automatically displayed by the sample analysis system based on the statistical results by a default value, and the default value may be manually modified by a user.

In one embodiment, each package of test items may be added or deleted via "add" and "delete" buttons. Therefore, the user can add or delete the test items according to the needs, and the diversified requirements of the user are met.

With continued reference to fig. 7, an interface is also shown for the real-time display of the centrifuge times for the individual centrifuge modules, which allows the user to visually see the current centrifuge times for the individual centrifuge modules. Three centrifuge modules are shown, it being understood that this is merely exemplary and one or more centrifuge modules may be added or deleted as desired by one skilled in the art via the "add" and "delete" buttons.

Example two

Still referring to fig. 1, the schematic structure of the sample analysis system according to the present embodiment may include a plurality of centrifuge modules 100, a plurality of tracks 110, a scheduling device 120, and a controller 130. The centrifugal module 100 is used for performing centrifugal operation on a sample to be detected; a plurality of rails 110 are respectively connected to the respective centrifuge modules 100; the dispatching device 120 is used for dispatching the samples to be tested to the corresponding centrifuge modules 100 through the plurality of tracks 110 for centrifugation. In one embodiment, the sample to be tested may include any suitable sample that can be tested in the medical field, such as a blood sample, a urine sample, and the like, but the invention is not limited thereto. Fig. 1 shows an example of three centrifuge modules 100, which are for illustrative purposes only and are not intended to limit the number of centrifuge modules. In some examples, other modules (e.g., analysis modules, etc.) and components for pre-processing and post-processing may be added to the sample analysis system, which may also be referred to as a pipeline system.

The present embodiment is different from the first embodiment in that the controller 130 is configured to set the centrifugation time of each of the centrifugation modules based on different time periods. In one embodiment, the different time periods may be divided based on how dense the samples arrive. For example, 00:00-09:00 is the first time period, 09:00-11:00 is the second time period, and 11:00-24:00 is the third time period. In one embodiment, the controller 130 controls the centrifugation time of the centrifugation module to be set short (e.g., 200 seconds) for a period of time when the sample is dense; the time period when the sample comes sparsely, the controller 130 controls to set the centrifugation time of the centrifugation module to be longer (e.g., 600 seconds). For example, in the example of the above time period, the centrifugation time of the 00:00-09:00 centrifuge module may be set to 600 seconds, the centrifugation time of the 09:00-11:00 centrifuge module may be set to 200 seconds, and the centrifugation time of the 11:00-24:00 centrifuge module may be set to 300 seconds. According to the embodiment, in the time period when the samples arrive densely, the centrifugal requirement of the lowest medical decision level can be met, and the centrifugation can be completed as soon as possible, so that the analysis result can be obtained as soon as possible, and in the time period when the samples arrive sparsely, the centrifugation of the samples can be more sufficient.

It is to be understood that the setting of the above time periods and the setting of the centrifugation times for the respective time periods are merely exemplary and are not intended to be limiting. In practical operation, a person skilled in the art can set different time periods and centrifugation times of the corresponding centrifugation modules according to needs.

In one embodiment, the respective time periods may be set according to the result of the autonomous statistics of the sample analysis system. For example, the step of setting the time period based on the statistical result may be:

1) counting the time point of each sample entering the system: t is t₀、t₁、t₂…

2) The time interval between two adjacent samples entering the system is: Δ t₁＝t₁-t₀、Δt₂＝t₂-t₁、Δt₃＝t₃-t₂…

3) Acquisition of different time periods:

(i) when Δ t is reached_i>Generating a trigger event at delta T, and recording the partition time period T₀～t_iAnd each sample 0-i in the time period;

(ii) when Δ t is reached_i+x1>Generating a trigger event at delta T, and recording the partition time period T_i+1～t_i+x1And each sample i +1 to i + x1 in the time period;

(iii) when Δ t is reached_i+x2>Generating a trigger event at delta T, and recording the partition time period T_i+x1+1～t_i+x2And each sample i + x1+1 to i + x2 within the time period;

…………

4) calculating sample density of each partitioned time segment

(i)t₀～t_iThe sample density of the time period is: (i-0+ 1)/(t)_i-t₀)；

(ii)t_i+1～t_i+x1The sample density of the time period is: [ (i + x1) - (i +1) +1]/(t_i+x1-t_i+1)；

(iii)t_i+x1+1～t_i+x2The sample density of the time period is: [ (i + x2) - (i + x1+1) +1]/(t_i+x2-t_i+x1+1)。

According to the embodiment, each time period is set according to the statistical sample density degree, and the time periods are divided more reasonably, so that the centrifugal time of the centrifugal module set according to different time periods is more reasonable, the centrifugal efficiency of the centrifugal module can be improved, and the redundancy of the centrifugal time can be obviously reduced.

With continued reference to FIG. 7, an interface for setting the centrifugation time for each centrifuge module for different time periods is also shown. Wherein a user may select a certain time period by means of a mouse and thus input a corresponding centrifugation time by means of a keyboard. Three time periods and three centrifuge modules are shown, it being understood that this is merely exemplary and one skilled in the art may add or delete one or more time periods via the "add" and "delete" buttons, or may add more centrifuge modules via the "add centrifuge module" and "delete centrifuge module" buttons, as desired.

EXAMPLE III

The difference from the first embodiment is that the controller 130 is configured to set the centrifugation time of each centrifugation module based on the customized sample type of the sample to be tested. The embodiment enables the centrifugation time of the centrifugation module to be flexibly set based on different sample types according to the needs of users, can reduce the redundancy of the centrifugation time to the maximum extent, and can improve the centrifugation efficiency of the centrifugation module.

In one embodiment, the custom sample types include a test item type, a time period sample type, a sample source type, and the like. One skilled in the art can add or delete custom sample types as desired, and the invention is not limited in this regard, and all custom sample types fall within the scope of the invention.

In embodiments where the custom sample type comprises a test item type, controller 130 is configured to set the centrifugation time for each centrifuge module based on the test item type of the sample under test. The centrifugal time required by each test item of the sample to be tested is different, so that the centrifugal time required by each sample to be tested is different, the centrifugal time of the centrifugal module is set according to the test item of the sample, the redundant phenomenon of the centrifugal time can be reduced to the greatest extent, and the centrifugal efficiency of the centrifugal module is improved.

In embodiments where the custom sample type comprises a time period sample type, the controller 130 is further configured to set the centrifugation times for the individual centrifugation modules based on different time periods. In one embodiment, the different time periods may be divided based on how dense the samples arrive. For example, 00:00-09:00 is the first time period, 09:00-11:00 is the second time period, and 11:00-24:00 is the third time period. In one embodiment, the controller 130 controls the centrifugation time of the centrifugation module to be set short (e.g., 200 seconds) for a period of time when the sample is dense; the time period when the sample comes sparsely, the controller 130 controls to set the centrifugation time of the centrifugation module to be longer (e.g., 600 seconds). For example, in the example of the above time period, the centrifugation time of the 00:00-09:00 centrifuge module may be set to 600 seconds, the centrifugation time of the 09:00-11:00 centrifuge module may be set to 200 seconds, and the centrifugation time of the 11:00-24:00 centrifuge module may be set to 300 seconds. According to the embodiment, in the time period when the samples arrive densely, the centrifugal requirement of the lowest medical decision level can be met, and the centrifugation can be completed as soon as possible, so that the analysis result can be obtained as soon as possible, and in the time period when the samples arrive sparsely, the centrifugation of the samples can be more sufficient.

It is to be understood that the setting of the above time periods and the setting of the centrifugation times for the respective time periods are merely exemplary and are not intended to be limiting. In practical operation, a person skilled in the art can set different time periods and centrifugation times of the corresponding centrifugation modules according to needs. In one embodiment, the respective time periods may be set according to the result of the autonomous statistics of the sample analysis system. The specific steps of setting the time period based on the statistical result can be seen in embodiment two, and are not repeated here.

In embodiments where the custom sample type comprises a sample source type, controller 130 is configured to set the centrifugation time for each centrifuge module based on the different sample sources. In one embodiment, the sample sources may include emergency samples, outpatient samples, and hospitalized samples. In one embodiment, if the sample to be tested is an emergency sample, the centrifugation time of the centrifuge module may be set to be short (e.g., 150 seconds); if the sample to be tested is an outpatient sample, the centrifugation time of the centrifugation module can be set to be longer (for example, 300 seconds); if the sample to be tested is a hospitalized sample, the centrifugation time of the centrifuge module may be set to be longer (e.g., 500 seconds). Thus, the emergency treatment sample can be centrifuged as soon as possible, and the hospitalization sample can be centrifuged more sufficiently.

In order to avoid frequent changes in the centrifugation time of the centrifuge module, and to enable the centrifuge efficiency of the centrifuge module to be improved and the TAT time of the system to be as short as possible, the intelligent scheduling mode may be initiated. In the intelligent scheduling mode, the controller 130 may determine which centrifuge module to schedule the sample to be tested to based on the relationship of the sample required centrifugation time of the sample to be tested to the current centrifugation time of each centrifuge module. The intelligent scheduling mode can schedule the sample to be detected to the centrifugal module with the centrifugal time most matched with the centrifugal time required by the sample, so that the scheduling of the sample is optimized to the maximum extent, the TAT time of the system can be effectively shortened, and the problem of resource waste caused by starting too many centrifugal modules is avoided.

Specifically, in the intelligent scheduling mode, firstly, it is determined to which centrifugal module to schedule the sample to be tested based on the first determination condition SR1, where the first determination condition SR1 includes: whether the centrifugation time required for the sample of the sample to be tested is less than or equal to the centrifugation time of at least one of the plurality of centrifugation modules 100.

Further, when the centrifugation time required for the sample of the sample to be tested is less than or equal to the centrifugation time of at least one of the plurality of centrifugation modules 100, the controller 130 controls the scheduling device 120 to schedule the sample to be tested to the centrifugation module of the at least one centrifugation module whose centrifugation time is the least different from the centrifugation time required for the sample of the sample to be tested. Therefore, the centrifugation time redundancy of the samples can be reduced as much as possible, and the TAT time of the samples is shortened.

The following description will be given taking an example in which the sample analysis system includes three centrifuge modules. For example, the centrifugation time required for a sample of a certain sample to be tested is 500 seconds, and the current centrifugation time of each centrifugation module 100 is: centrifuge module 1 for 300 seconds, centrifuge module 2 for 480 seconds, and centrifuge module 3 for 600 seconds, the sample to be tested will be dispatched to centrifuge module 3 so that the centrifuge time for each centrifuge module 100 will remain unchanged. For another example, the centrifugation time required for a sample of a certain sample to be measured is 420 seconds, and the current centrifugation time of each centrifugation module is: if the centrifugal module 1 is 300 seconds, the centrifugal module 2 is 480 seconds, and the centrifugal module 3 is 600 seconds, the sample to be tested is dispatched to the centrifugal module 2, so that the centrifugal time of each centrifugal module remains unchanged, the TAT time of the sample analysis system is not increased, and the centrifugal time redundancy of the sample to be tested is smaller.

Further, when the centrifugation time required for the sample of the sample to be tested is greater than the centrifugation time of all the centrifugation modules 100 and there is no centrifugation module 100 without the sample, the controller 130 controls the scheduling device 120 to schedule the sample to be tested to the centrifugation module of the plurality of centrifugation modules 100 whose centrifugation time is the smallest difference from the centrifugation time required for the sample of the sample to be tested. For example, the centrifugation time required for a sample of a certain sample is 500 seconds, and the current centrifugation time of each centrifugation module 100 is: the centrifugation module 1 is 200 seconds, the centrifugation module 2 is 300 seconds, and the centrifugation module 3 is 400 seconds, the sample to be tested is dispatched to the centrifugation module 3, and the centrifugation time of the centrifugation module 3 is changed from 400 seconds to 500 seconds. This operation minimizes the increase in TAT time for the sample analysis system.

In the intelligent scheduling mode, secondly, when the centrifugation time required for a sample of a sample to be tested is greater than the centrifugation time of all the centrifugation modules 100 and there is at least one centrifugation module 100 without a sample, it is determined to which centrifugation module the sample to be tested is scheduled based on the second determination condition SR 2. Wherein the second determination condition includes: whether the centrifugal time required by the sample of the sample to be detected is less than or equal to a preset judgment threshold TH of any centrifugal module in the centrifugal modules without the sample. Each of the centrifuge modules 100 has a determination threshold TH, and the determination threshold TH of each of the centrifuge modules 100 may be set according to experience or actual needs. The purpose of setting the judgment threshold is to increase the TAT time of the sample analysis system as little as possible and avoid resource waste caused by starting more centrifuge modules.

Further, when the centrifugation time required for the sample of the sample to be tested is less than or equal to the determination threshold of all centrifugation modules 100 without the sample, the controller 130 controls the dispatching device 120 to dispatch the sample to be tested to the centrifugation module 100 whose centrifugation time is the smallest difference from the centrifugation time required for the sample of the sample to be tested. The sample analysis system is described as including four centrifuge modules. For example, the centrifugation time required for a sample of a certain sample to be tested is 280 seconds, and the current centrifugation time of each centrifugation module 100 is: if centrifuge module 1 is 200 seconds (determination threshold is 200 seconds), centrifuge module 2 is 250 (determination threshold is 300 seconds), centrifuge module 3 is 0 (determination threshold is 300 seconds), and centrifuge module 4 is 0 (determination threshold is 400 seconds), the sample is scheduled to centrifuge module 2, and the centrifuge time of centrifuge module 2 is changed from 250 seconds to 280 seconds. This operation minimizes the increase in TAT time for the sample analysis system, while avoiding the waste of resources caused by starting more centrifuge modules.

Further, when the centrifugation time required for the sample of the sample to be tested is greater than the determination threshold of at least one centrifugal module in the non-sample centrifugal module 100, the controller 130 controls the dispatching device 120 to dispatch the sample to be tested to the centrifugal module with the smallest difference between the determination threshold of the non-sample centrifugal module and the centrifugation time required for the sample of the sample to be tested. The sample analysis system is described as including three centrifuge modules. For example, the centrifugation time required for a sample of a sample 1 is 390 seconds, and the current centrifugation time of each centrifugation module 100 is: if centrifuge module 1 is 200 seconds (determination threshold is 200 seconds), centrifuge module 2 is 0 (determination threshold is 300 seconds), and centrifuge module 3 is 0 (determination threshold is 400 seconds), the sample will be dispatched to centrifuge module 3, and the centrifuge time of centrifuge module 3 is changed from 0 to 390 seconds. This operation minimizes the increase in TAT time for the sample analysis system, while avoiding the waste of resources caused by starting more centrifuge modules.

Wherein the intelligent scheduling mode may be set to be enabled or disabled. In one embodiment, the intelligent scheduling mode may be set to be enabled or disabled based on different time periods. For example, 00:00-09:00 and 11:00-24:00 are generally states where samples arrive intermittently, and the intelligent scheduling mode may be set to disabled; 09:00-11:00 is typically a peak time period of sample arrival, with a large number of samples arriving, and the intelligent scheduling mode may be set to enabled. It should be understood that other intelligent scheduling mode enabling/disabling conditions may be set as desired by those skilled in the art, and the invention is not limited in this regard. By the operation, the scheduling of the samples can be optimized in the sample peak time period, the centrifugal time redundancy of the samples is reduced, and the waste of resources caused by starting more centrifugal modules due to intelligent scheduling is avoided in the sample off-peak time period.

With continued reference to FIG. 7, in addition to the above-described arrangement, FIG. 7 may also include an interface for setting the intelligent centrifuge module schedule.

Wherein, the user can select a certain time period through the mouse, thereby selecting the enabling/disabling of the intelligent scheduling policy in the time period. The user can select a certain centrifugal module through a mouse, so that the corresponding judgment threshold value is input through a keyboard.

Three time periods and three centrifuge modules are shown, it being understood that this is merely exemplary and one skilled in the art may add or delete one or more time periods via the "add" and "delete" buttons as desired, or may add more centrifuge modules and their corresponding decision thresholds via the "add centrifuge module" and "delete centrifuge module" buttons.

Example four

Referring now to fig. 2, fig. 2 is a schematic diagram illustrating a sample analysis system according to another embodiment of the invention. The sample analysis system in fig. 2 may include one or more of an input module 140, a pre-processing module 150, a post-processing module 160, and an analysis module 170, in addition to the plurality of centrifuge modules 100, the track 110, the scheduling device 120, and the controller 130. The plurality of tracks 110 are used for connecting the modules, such as the input module 140, the centrifuge module 100, the pre-processing module 150, the analysis module 170, the post-processing module 160, and the like; the dispatching device 120 dispatches the samples to the corresponding modules through the track 110; the controller 130 is used for setting the centrifugation time of each centrifugation module 100, and may include a controller as described in any one of the first, second, and third embodiments, which will not be described herein. Fig. 2 shows an example of two centrifuge modules 100, which is for illustration only and is not intended to limit the number of centrifuge modules; the modules are explained below.

The input module 140 is used for receiving a sample to be tested placed by a user. The input module 140 in the pipeline system is generally the area where the user puts the sample, and when the pipeline system is in operation, the input module 140 can automatically scan the sample put therein, sort the sample, and the like, so as to be processed by the next module, such as the centrifuge module 100.

The centrifuge module 100 is used for centrifuging a sample to be measured. The centrifugation time of the centrifuge module 100 may be set with reference to the various embodiments described above.

The pre-processing module 150 is used for completing the pre-processing of the centrifuged sample. Referring to fig. 3, fig. 3 is a schematic structural diagram of a preprocessing module 150 according to an embodiment of the invention. The pre-processing module 150 in fig. 3 may include one or more of a serum detection module 152, a decapping module 153, and a dispensing module 154. The serum detection module 152 is used to detect whether the serum amount of the sample is sufficient and/or whether the serum quality of the sample is acceptable, so as to determine whether the centrifuged sample can be used for subsequent determination. The decapping module 153 is used for decapping the centrifuged sample — as will be understood, capping, coating, decapping, and decapping the sample herein, it refers to capping, coating, decapping, and decapping the sample tube containing the sample; typically, the sample needs to be uncapped after centrifugation for subsequent dispensing or pipetting in the dispensing module 154 or the analysis module 170. The dispensing module 154 is used to dispense a sample, such as a single sample into multiple samples, for testing in different analysis modules 170. The preprocessing module 150 generally has a preprocessing flow: the centrifugation module 100 receives the sample scheduled by the input module 140 and centrifuges the sample; the serum detection module 152 detects serum of the centrifuged sample, and determines whether the serum can be used for subsequent measurement, and if the serum amount is not enough or the quality is not qualified, the serum cannot be used for subsequent measurement; if the detection is passed, the sample is dispatched to the decapping module 153 again, the decapping module 153 removes the cap of the sample, and if the dispensing module 154 is available, the dispensing module 154 sorts the decapped sample, and then dispatches the sorted sample to the corresponding analysis module 170 for measurement. If there is no dispensing module 154, the sample is dispatched from the decapping module 153 to the corresponding analysis module 170 for assaying.

The analysis module 170 includes an analyzer for testing the centrifuged and uncapped sample to be tested.

The post-processing module 160 is used to complete post-processing of the sample. In one embodiment, referring to fig. 4, fig. 4 is a schematic structural diagram of the post-processing module 160 according to an embodiment of the invention. The post-treatment module 160 in fig. 4 includes one or more of a capping/filming module 161, a refrigerated storage module 162, and a decapping/decapping module 163. The membrane/capping module 161 is used for membrane or capping the sample; the refrigerated storage module 162 is used for storing samples; the stripping/decapping module 163 is used to strip or decap a sample. One general post-processing flow for post-processing module 160 is: after the sample is aspirated by the analysis module 170, the sample is dispatched to the membrane/capping module 161, and the membrane/capping module 161 performs membrane or capping on the sample after the assay is completed, and then dispatches the sample to the refrigerated storage module 162 for storage. If the sample requires retesting, the sample is dispatched from the refrigerated storage module 162, stripped or decapped in a stripping/decapping module 163, and then dispatched to the analysis module 170 for testing.

Fig. 5 is a schematic structural diagram of a pipeline system of circular tracks, in which the directions of dotted arrows are the directions and routes of sample travel, and a curved section of track at the upper right corner is an example of a system buffer zone, according to an embodiment of the present invention.

The sample analysis system of the present invention may also include an input module for a user to input commands, typically a mouse and a keyboard, and a display module. The display module is used for displaying contents, such as contents related to the centrifugation time setting of the centrifugation module. The display interface of the display module can be as shown in the first, second and third embodiments, and is not described herein again.

EXAMPLE five

As shown in fig. 6, fig. 6 is a flowchart illustrating steps of a method S10 for controlling a sample analysis system to be tested, wherein the sample analysis system to be tested includes a plurality of centrifuge modules, according to an embodiment of the present invention, the method S10 includes the following steps:

in step S200, acquiring a centrifugation time required for a sample of a sample to be tested reaching the centrifugation module, wherein the centrifugation time required for the sample of the sample to be tested is preset as a longest centrifugation time among the centrifugation times required for the respective test items of the sample to be tested;

in step S400, the centrifugation time of the centrifugation module is set to the longest centrifugation time among the centrifugation times required for the samples of the respective samples to be measured.

EXAMPLE six

The present embodiment provides a computer-readable medium having stored thereon a computer program which, when executed, performs the method as described in the above embodiments. Any tangible, non-transitory computer-readable medium may be used, including magnetic storage devices (hard disks, floppy disks, etc.), optical storage devices (CD-ROMs, DVDs, Blu-ray disks, etc.), flash memory, and/or the like. These computer program instructions may be loaded onto a general purpose computer, special purpose computer, or other programmable data processing apparatus to produce a machine, such that the instructions which execute on the computer or other programmable data processing apparatus create means for implementing the functions specified. These computer program instructions may also be stored in a computer-readable memory that can direct a computer or other programmable data processing apparatus to function in a particular manner, such that the instructions stored in the computer-readable memory produce an article of manufacture including means for implementing the function specified. The computer program instructions may also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer implemented process such that the instructions which execute on the computer or other programmable apparatus provide steps for implementing the functions specified.

Although the illustrative embodiments have been described herein with reference to the accompanying drawings, it is to be understood that the foregoing illustrative embodiments are merely exemplary and are not intended to limit the scope of the invention thereto. Various changes and modifications may be effected therein by one of ordinary skill in the pertinent art without departing from the scope or spirit of the present invention. All such changes and modifications are intended to be included within the scope of the present invention as set forth in the appended claims.

In the description provided herein, numerous specific details are set forth. It is understood, however, that embodiments of the invention may be practiced without these specific details. In some instances, well-known methods, structures and techniques have not been shown in detail in order not to obscure an understanding of this description.

Similarly, it should be appreciated that in the description of exemplary embodiments of the invention, various features of the invention are sometimes grouped together in a single embodiment, figure, or description thereof for the purpose of streamlining the invention and aiding in the understanding of one or more of the various inventive aspects. However, the method of the present invention should not be construed to reflect the intent: that the invention as claimed requires more features than are expressly recited in each claim. Rather, as the following claims reflect, inventive aspects lie in less than all features of a single disclosed embodiment. Thus, the claims following the detailed description are hereby expressly incorporated into this detailed description, with each claim standing on its own as a separate embodiment of this invention.

It will be understood by those skilled in the art that all of the features disclosed in this specification (including any accompanying claims, abstract and drawings), and all of the processes or elements of any method or apparatus so disclosed, may be combined in any combination, except combinations where such features are mutually exclusive. Each feature disclosed in this specification (including any accompanying claims, abstract and drawings) may be replaced by alternative features serving the same, equivalent or similar purpose, unless expressly stated otherwise.

Furthermore, those skilled in the art will appreciate that while some embodiments described herein include some features included in other embodiments, rather than other features, combinations of features of different embodiments are meant to be within the scope of the invention and form different embodiments. For example, in the claims, any of the claimed embodiments may be used in any combination.

It should be noted that the above-mentioned embodiments illustrate rather than limit the invention, and that those skilled in the art will be able to design alternative embodiments without departing from the scope of the appended claims. In the claims, any reference signs placed between parentheses shall not be construed as limiting the claim. The word "comprising" does not exclude the presence of elements or steps not listed in a claim. The word "a" or "an" preceding an element does not exclude the presence of a plurality of such elements. The invention may be implemented by means of hardware comprising several distinct elements, and by means of a suitably programmed computer. In the unit claims enumerating several means, several of these means may be embodied by one and the same item of hardware. The usage of the words first, second and third, etcetera do not indicate any ordering. These words may be interpreted as names.

The above description is only for the specific embodiment of the present invention or the description thereof, and the protection scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and the changes or substitutions should be covered within the protection scope of the present invention. The protection scope of the present invention shall be subject to the protection scope of the claims.

Claims

1. A sample analysis system, comprising:

the centrifugal modules are used for carrying out centrifugal operation on a sample to be detected;

a plurality of rails respectively connected to the centrifugal modules;

the dispatching device is used for dispatching the sample to be tested to the corresponding centrifugal module through the track so as to carry out centrifugal operation;

a controller for setting centrifugation times of the respective centrifugation modules based on a test item of the sample to be tested.

2. The sample analysis system of claim 1, wherein the controller is further configured to: and when the sample to be detected reaches the centrifugal module, acquiring the centrifugal time required by the sample of the sample to be detected, and setting the centrifugal time of the centrifugal module as the longest centrifugal time in the centrifugal time required by the sample of each sample to be detected.

3. The system of claim 2, wherein the centrifugation time required for the sample of the sample to be tested is preset based on the centrifugation time required for each test item of the sample to be tested.

4. The system according to claim 3, wherein the centrifugation time required for the sample of the sample to be tested is preset to be the longest centrifugation time among the centrifugation times required for the respective test items of the sample to be tested.

5. A sample analysis system, comprising:

a plurality of rails respectively connected to the centrifugal modules;

a controller for setting centrifugation times of the respective centrifugation modules based on the different time periods.

6. A sample analysis system, comprising:

a plurality of rails respectively connected to the centrifugal modules;

a controller for setting the centrifugation time of each centrifugation module based on the customized sample type of the sample to be tested.

7. The sample analysis system of claim 6, wherein the customized sample type comprises a test item type, and wherein the controller is further configured to set a centrifugation time for each centrifugation module based on the test item type of the sample under test.

8. The sample analysis system of claim 7, wherein the controller is further configured to: and when the sample to be detected reaches the centrifugal module, acquiring the centrifugal time required by the sample of the sample to be detected, and setting the centrifugal time of the centrifugal module as the longest centrifugal time in the centrifugal time required by the sample of each sample to be detected.

9. The system of claim 8, wherein the centrifugation time required for the sample of the sample to be tested is preset based on the centrifugation time required for each test item of the sample to be tested.

10. The system of claim 9, wherein the centrifugation time required for the sample of the sample to be tested is preset to be the longest centrifugation time among the centrifugation times required for the respective test items of the sample to be tested.

11. The sample analysis system of any one of claims 6 to 10, wherein the controller is further configured to: determining to which centrifugal module the sample to be tested is scheduled based on a first determination condition, wherein the first determination condition includes whether a required centrifugation time of the sample to be tested is less than or equal to a centrifugation time of at least one centrifugal module of the plurality of centrifugal modules.

12. The sample analysis system of claim 11, wherein the controller is further configured to: when the centrifugal time required by the sample of the sample to be detected is less than or equal to the centrifugal time of at least one centrifugal module in the plurality of centrifugal modules, controlling the scheduling device to schedule the sample to be detected to the centrifugal module with the centrifugal time having the smallest difference with the centrifugal time required by the sample of the sample to be detected in the at least one centrifugal module.

13. The sample analysis system of claim 11, wherein the controller is further configured to: and when the centrifugal time required by the sample of the sample to be detected is greater than the centrifugal time of all the centrifugal modules and no centrifugal module without the sample exists, controlling the scheduling device to schedule the sample to be detected to the centrifugal module with the centrifugal time having the smallest difference with the centrifugal time required by the sample of the sample to be detected in the plurality of centrifugal modules.

14. The sample analysis system of claim 11, wherein the controller is further configured to: when the centrifugal time required by the sample of the sample to be detected is greater than the centrifugal time of all the centrifugal modules and at least one centrifugal module without the sample exists, determining which centrifugal module the sample to be detected is dispatched to based on a second judgment condition, wherein the second judgment condition comprises whether the centrifugal time required by the sample of the sample to be detected is less than or equal to a preset judgment threshold value of any centrifugal module in the centrifugal modules without the sample.

15. The sample analysis system of claim 14, wherein the controller is further configured to: and when the centrifugal time required by the sample of the sample to be detected is less than or equal to the judgment threshold of all centrifugal modules without the sample, controlling the scheduling device to schedule the sample to be detected to the centrifugal module with the centrifugal time having the smallest difference with the centrifugal time required by the sample of the sample to be detected.

16. The sample analysis system of claim 14, wherein the controller is further configured to: when the centrifugal time required by the sample of the sample to be detected is larger than the judgment threshold value of at least one centrifugal module in the sample-free centrifugal modules, controlling the dispatching device to dispatch the sample to be detected to the centrifugal module with the smallest difference between the judgment threshold value of the sample to be detected and the centrifugal time required by the sample of the sample to be detected in the sample-free centrifugal modules.

17. The sample analysis system of claim 11, wherein the first determination condition can be set to enable or disable based on different time periods.

18. The sample analysis system of claim 6, wherein the customized sample type comprises a time period sample type, and wherein the controller is further configured to set a centrifugation time for each centrifugation module based on a different time period.

19. The sample analysis system of claim 6, wherein the customized sample type comprises a sample source type, and wherein the controller is further configured to set a centrifugation time for each centrifugation module based on a different sample source.

20. The sample analysis system of claim 19, wherein the controller is further configured to: and when the sample to be detected reaches the centrifugal module, acquiring the required centrifugal time of the sample to be detected, and setting the centrifugal time of the centrifugal module as the longest centrifugal time in the required centrifugal time of the sample of each sample to be detected reaching the centrifugal module.

21. The system of claim 20, wherein the centrifugation time required for the sample is preset based on the centrifugation time required for each test item of the sample to be tested.

22. The system of claim 21, wherein the centrifugation time required for the sample is preset to be the longest centrifugation time among the centrifugation times required for the respective test items of the sample to be tested.

23. A method for controlling a sample analysis system under test comprising a plurality of centrifuge modules, the method comprising:

acquiring the centrifugal time required by a sample of a sample to be tested reaching the centrifugal module, wherein the centrifugal time required by the sample of the sample to be tested is preset as the longest centrifugal time in the centrifugal time required by each test item of the sample to be tested;

and setting the centrifugation time of the centrifugation module as the longest centrifugation time in the centrifugation time needed by the sample of each sample to be tested.

24. A computer-readable medium, in which a computer program is stored which, when executed, performs the method of claim 23.