CN112552168A - Process method for preparing ethyl lactate by rectification - Google Patents
Process method for preparing ethyl lactate by rectification Download PDFInfo
- Publication number
- CN112552168A CN112552168A CN202011492656.1A CN202011492656A CN112552168A CN 112552168 A CN112552168 A CN 112552168A CN 202011492656 A CN202011492656 A CN 202011492656A CN 112552168 A CN112552168 A CN 112552168A
- Authority
- CN
- China
- Prior art keywords
- rectification
- tower
- ethyl lactate
- catalytic
- lactide
- Prior art date
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- LZCLXQDLBQLTDK-UHFFFAOYSA-N ethyl 2-hydroxypropanoate Chemical compound CCOC(=O)C(C)O LZCLXQDLBQLTDK-UHFFFAOYSA-N 0.000 title claims abstract description 96
- 229940116333 ethyl lactate Drugs 0.000 title claims abstract description 48
- 238000000034 method Methods 0.000 title claims abstract description 33
- 230000008569 process Effects 0.000 title claims abstract description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 96
- 230000003197 catalytic effect Effects 0.000 claims abstract description 78
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims abstract description 48
- 150000002148 esters Chemical class 0.000 claims abstract description 32
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims abstract description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 30
- 238000007670 refining Methods 0.000 claims abstract description 22
- 238000006243 chemical reaction Methods 0.000 claims abstract description 12
- 238000005886 esterification reaction Methods 0.000 claims abstract description 12
- 238000004519 manufacturing process Methods 0.000 claims abstract description 10
- 239000000463 material Substances 0.000 claims abstract description 10
- 239000003054 catalyst Substances 0.000 claims abstract description 6
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims abstract description 3
- 239000002253 acid Substances 0.000 claims abstract description 3
- 239000003729 cation exchange resin Substances 0.000 claims abstract description 3
- 238000012856 packing Methods 0.000 claims description 27
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 22
- 239000004310 lactic acid Substances 0.000 claims description 11
- 235000014655 lactic acid Nutrition 0.000 claims description 11
- 230000035484 reaction time Effects 0.000 claims description 9
- 229910001220 stainless steel Inorganic materials 0.000 claims description 9
- 239000010935 stainless steel Substances 0.000 claims description 9
- 239000002841 Lewis acid Substances 0.000 claims description 6
- 150000007517 lewis acids Chemical group 0.000 claims description 6
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical class [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims description 5
- 229910021626 Tin(II) chloride Inorganic materials 0.000 claims description 5
- JJTUDXZGHPGLLC-ZXZARUISSA-N (3r,6s)-3,6-dimethyl-1,4-dioxane-2,5-dione Chemical compound C[C@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-ZXZARUISSA-N 0.000 claims description 4
- 238000006555 catalytic reaction Methods 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 11
- 238000004821 distillation Methods 0.000 description 9
- 230000032050 esterification Effects 0.000 description 8
- 238000000926 separation method Methods 0.000 description 8
- 239000002904 solvent Substances 0.000 description 8
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- 230000008901 benefit Effects 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 239000002932 luster Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 235000014101 wine Nutrition 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000013064 chemical raw material Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000006482 condensation reaction Methods 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 239000012450 pharmaceutical intermediate Substances 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
- C07C67/54—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation by distillation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/10—Process efficiency
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
The invention is suitable for the technical field of ethyl lactate production, and provides a process method for preparing ethyl lactate by rectification, which comprises the following steps: adding lactide and ethanol into a catalytic rectifying tower filled with a strong acid type cation exchange resin catalyst, forming an azeotrope by ethyl acetate and water generated by catalytic esterification reaction, distilling the azeotrope from the top of the catalytic rectifying tower, and passing the azeotrope through a phase separator to obtain crude ester; and (3) extracting the obtained crude ester into a refining tower, extracting a finished product ethyl lactate from the bottom of the refining tower, and returning the top material to the catalytic rectification tower. The lactide and the ethanol are subjected to catalytic reaction in a catalytic rectifying tower to generate the ethyl lactate. The content of ethanol in the crude ester is effectively reduced through the reaction rectification, and ethyl lactate with the purity of more than or equal to 99.95 percent can be obtained by a refining tower.
Description
Technical Field
The invention belongs to the technical field of ethyl lactate production, and particularly relates to a process method for preparing ethyl lactate by rectification.
Background
The molecular formula of the ethyl lactate is C5H10O3, the melting point is-126 ℃, the boiling point is 154 ℃, and the ethyl lactate can be mutually dissolved with water and is an important chemical raw material. As the solvent has the advantages of no toxicity, good solubility, difficult volatilization, biodegradability and the like, the solvent can be used as a green solvent with great development value to replace the traditional toxic solvents used in the industry at present, such as halogenated solvents, ethers solvents, chlorofluorocarbons solvents, such as cleaning oil field pipelines, preparing various high-grade paints and the like; ethyl lactate is also an edible flavor with wine aroma, is used for preparing various wines and edible essences, and can also be used as a flavoring agent in the feed industry; in addition, it is used as a lubricant for tablet compression, a pharmaceutical intermediate, etc. in the pharmaceutical industry; ethyl lactate has wide industrial applications.
The synthesis industry of ethyl lactate generally adopts an intermittent esterification method, lactic acid and ethanol are subjected to esterification reaction under the action of a concentrated sulfuric acid catalyst, then benzene or toluene is used as a water-carrying agent, water generated in a reaction system is removed, so that balance is moved forward, a crude product of ethyl lactate is obtained, and a food-grade product is obtained through intermittent reduced pressure distillation. The process has the problems that the produced ethyl lactate is often limited in use as a green solvent due to the fact that benzene or toluene as a water-carrying agent is toxic, and the concentrated sulfuric acid can promote the lactic acid to generate side reactions such as intermolecular and intramolecular dehydration reaction, condensation reaction, cyclization reaction and the like, so that the ethyl lactate product is poor in color and luster, low in yield and not beneficial to large-scale industrial popularization.
Disclosure of Invention
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The embodiment of the invention provides a process method for preparing ethyl lactate by rectification, aiming at solving the problems of poor color and luster and low yield of the existing ethyl lactate product.
The embodiment of the invention is realized in such a way that the process method for preparing ethyl lactate by rectification comprises the following steps:
1) adding lactide and ethanol into a catalytic rectifying tower filled with a strong acid type cation exchange resin catalyst, forming an azeotrope by ethyl acetate and water generated by catalytic esterification reaction, distilling the azeotrope from the top of the catalytic rectifying tower, and passing the azeotrope through a phase separator to obtain crude ester;
2) and extracting the obtained crude ester into a refining tower, extracting a finished product ethyl lactate from the bottom of the refining tower, and returning the top material to the catalytic rectification tower.
As a further scheme of the invention: the lactide is selected from one or more of L lactide, D lactide or meso lactide.
As a further scheme of the invention: the ethanol is absolute ethanol.
As a further scheme of the invention: the lactide is added from the upper part of a catalytic rectifying section of a catalytic rectifying tower, the ethanol is added from a tower kettle, an azeotrope formed by lactic acid and water is obtained from the catalytic rectifying section, and after separation is carried out in the rectifying section, the lactide enters a phase separator to respectively obtain crude ester and a water phase.
As a further scheme of the invention: the catalyst is Lewis acid or tin salt.
As a further scheme of the invention: the reaction temperature is 82-100 ℃, and the reaction time is 3-10 h.
As a further scheme of the invention: the molar ratio of lactide to ethanol is 3: (2-10).
As a further scheme of the invention: the catalytic distillation tower is a packed tower, and the used packing is stainless steel random packing or regular packing.
The invention generates ethyl lactate by the catalytic reaction of lactide and ethanol in a catalytic rectifying tower. The content of ethanol in the crude ester is effectively reduced through the reaction rectification, and ethyl lactate with the purity of more than or equal to 99.95 percent can be obtained by a refining tower. The method reduces the alcohol content in the crude ester to the maximum extent, reduces the circulation of the ethanol in a system, and saves energy consumption; the raw material lactide used in the invention has no optical rotation requirement, can be L lactide, D lactide, racemic lactide or a mixture of a plurality of lactides, has wide application range, and can particularly reuse the racemic lactide which is not beneficial to producing high-quality polylactic acid to produce ethyl lactate, thereby realizing the comprehensive utilization of the raw material, also achieving the maximization of economic benefit and having quite high economic price.
Detailed Description
The technical effects of the process for preparing ethyl lactate by rectification and the oat obtained by the process are further described below with reference to specific examples, but the specific implementation methods mentioned in the examples are only illustrative and explanatory of the technical scheme of the present invention, and do not limit the implementation scope of the present invention, and all modifications and substitutions based on the above principles should be within the protection scope of the present invention.
Example 1
A process method for preparing ethyl lactate by rectification comprises the following steps: 1) adding the L lactide and ethanol into a catalytic rectifying tower filled with Lewis acid, and distilling off an azeotrope formed by ethyl acetate and water generated by catalytic esterification from the top of the catalytic rectifying tower through a phase separator to obtain crude ester; 2) and extracting the obtained crude ester into a refining tower, extracting a finished product ethyl lactate from the bottom of the refining tower, and returning the top material to the catalytic rectification tower.
Specifically, the ethanol is absolute ethanol.
Specifically, the reaction temperature is 82 ℃, and the reaction time is 3 hours.
Further, lactide is added from the upper part of a catalytic rectifying section of the catalytic rectifying tower, ethanol is added from a tower kettle, an azeotrope formed by lactic acid and water is obtained from the catalytic rectifying section, and after separation is carried out in the rectifying section, the lactide enters a phase separator to obtain crude ester and a water phase respectively.
Specifically, the molar ratio of lactide to ethanol is 3: 2.
specifically, the catalytic distillation tower is a packed tower, and the used packing is stainless steel random packing or regular packing.
Example 2
A process method for preparing ethyl lactate by rectification comprises the following steps: 1) adding the D lactide and ethanol into a catalytic rectifying tower filled with tin salt, and distilling off an azeotrope formed by ethyl acetate and water generated by catalytic esterification from the top of the catalytic rectifying tower through a phase separator to obtain crude ester; 2) and extracting the obtained crude ester into a refining tower, extracting a finished product ethyl lactate from the bottom of the refining tower, and returning the top material to the catalytic rectification tower.
Specifically, the ethanol is absolute ethanol.
The reaction temperature is 100 ℃, and the reaction time is 10 h.
Further, lactide is added from the upper part of a catalytic rectifying section of the catalytic rectifying tower, ethanol is added from a tower kettle, an azeotrope formed by lactic acid and water is obtained from the catalytic rectifying section, and after separation is carried out in the rectifying section, the lactide enters a phase separator to obtain crude ester and a water phase respectively.
Specifically, the molar ratio of lactide to ethanol is 3: 10.
specifically, the catalytic distillation tower is a packed tower, and the used packing is stainless steel random packing or regular packing.
Example 3
A process method for preparing ethyl lactate by rectification comprises the following steps: 1) adding meso lactide and ethanol into a catalytic rectifying tower filled with Lewis acid, and distilling off an azeotrope formed by ethyl acetate and water generated by catalytic esterification from the top of the catalytic rectifying tower through a phase separator to obtain crude ester; 2) and extracting the obtained crude ester into a refining tower, extracting a finished product ethyl lactate from the bottom of the refining tower, and returning the top material to the catalytic rectification tower.
Specifically, the ethanol is absolute ethanol.
Specifically, the reaction temperature is 85 ℃, and the reaction time is 5 hours.
Further, lactide is added from the upper part of a catalytic rectifying section of the catalytic rectifying tower, ethanol is added from a tower kettle, an azeotrope formed by lactic acid and water is obtained from the catalytic rectifying section, and after separation is carried out in the rectifying section, the lactide enters a phase separator to obtain crude ester and a water phase respectively.
Specifically, the molar ratio of lactide to ethanol is 3: 4.
specifically, the catalytic distillation tower is a packed tower, and the used packing is stainless steel random packing or regular packing.
Example 4
A process method for preparing ethyl lactate by rectification comprises the following steps: 1) adding the L lactide and ethanol into a catalytic rectifying tower filled with Lewis acid, and distilling off an azeotrope formed by ethyl acetate and water generated by catalytic esterification from the top of the catalytic rectifying tower through a phase separator to obtain crude ester; 2) and extracting the obtained crude ester into a refining tower, extracting a finished product ethyl lactate from the bottom of the refining tower, and returning the top material to the catalytic rectification tower.
Specifically, the ethanol is absolute ethanol.
Specifically, the reaction temperature is 90 ℃, and the reaction time is 7 h.
Further, lactide is added from the upper part of a catalytic rectifying section of the catalytic rectifying tower, ethanol is added from a tower kettle, an azeotrope formed by lactic acid and water is obtained from the catalytic rectifying section, and after separation is carried out in the rectifying section, the lactide enters a phase separator to obtain crude ester and a water phase respectively.
Specifically, the molar ratio of lactide to ethanol is 3: 6.
specifically, the catalytic distillation tower is a packed tower, and the used packing is stainless steel random packing or regular packing.
Example 5
A process method for preparing ethyl lactate by rectification comprises the following steps: 1) adding the L lactide and ethanol into a catalytic rectifying tower filled with Lewis acid, and distilling off an azeotrope formed by ethyl acetate and water generated by catalytic esterification from the top of the catalytic rectifying tower through a phase separator to obtain crude ester; 2) and extracting the obtained crude ester into a refining tower, extracting a finished product ethyl lactate from the bottom of the refining tower, and returning the top material to the catalytic rectification tower.
Specifically, the ethanol is absolute ethanol.
Specifically, the reaction temperature is 92 ℃, and the reaction time is 7 h.
Further, lactide is added from the upper part of a catalytic rectifying section of the catalytic rectifying tower, ethanol is added from a tower kettle, an azeotrope formed by lactic acid and water is obtained from the catalytic rectifying section, and after separation is carried out in the rectifying section, the lactide enters a phase separator to obtain crude ester and a water phase respectively.
Specifically, the molar ratio of lactide to ethanol is 3: 8.
specifically, the catalytic distillation tower is a packed tower, and the used packing is stainless steel random packing or regular packing.
Example 6
A process method for preparing ethyl lactate by rectification comprises the following steps: 1) adding the D lactide and ethanol into a catalytic rectifying tower filled with tin salt, and distilling off an azeotrope formed by ethyl acetate and water generated by catalytic esterification from the top of the catalytic rectifying tower through a phase separator to obtain crude ester; 2) and extracting the obtained crude ester into a refining tower, extracting a finished product ethyl lactate from the bottom of the refining tower, and returning the top material to the catalytic rectification tower.
Specifically, the ethanol is absolute ethanol.
Specifically, the reaction temperature is 95 ℃, and the reaction time is 8 h.
Further, lactide is added from the upper part of a catalytic rectifying section of the catalytic rectifying tower, ethanol is added from a tower kettle, an azeotrope formed by lactic acid and water is obtained from the catalytic rectifying section, and after separation is carried out in the rectifying section, the lactide enters a phase separator to obtain crude ester and a water phase respectively.
Specifically, the molar ratio of lactide to ethanol is 3: 8.
specifically, the catalytic distillation tower is a packed tower, and the used packing is stainless steel random packing or regular packing.
Example 7
A process method for preparing ethyl lactate by rectification comprises the following steps: 1) adding meso lactide and ethanol into a catalytic rectifying tower filled with tin salt, and distilling off an azeotrope formed by ethyl acetate and water generated by catalytic esterification from the top of the catalytic rectifying tower through a phase separator to obtain crude ester; 2) and extracting the obtained crude ester into a refining tower, extracting a finished product ethyl lactate from the bottom of the refining tower, and returning the top material to the catalytic rectification tower.
Specifically, the ethanol is absolute ethanol.
Specifically, the reaction temperature is 97 ℃, and the reaction time is 3-9 h.
Further, lactide is added from the upper part of a catalytic rectifying section of the catalytic rectifying tower, ethanol is added from a tower kettle, an azeotrope formed by lactic acid and water is obtained from the catalytic rectifying section, and after separation is carried out in the rectifying section, the lactide enters a phase separator to obtain crude ester and a water phase respectively.
Specifically, the molar ratio of lactide to ethanol is 3: 9.
specifically, the catalytic distillation tower is a packed tower, and the used packing is stainless steel random packing or regular packing.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.
Claims (8)
1. A process method for preparing ethyl lactate by rectification is characterized by comprising the following steps:
1) adding lactide and ethanol into a catalytic rectifying tower filled with a strong acid type cation exchange resin catalyst, forming an azeotrope by ethyl acetate and water generated by catalytic esterification reaction, distilling the azeotrope from the top of the catalytic rectifying tower, and passing the azeotrope through a phase separator to obtain crude ester;
2) and extracting the obtained crude ester into a refining tower, extracting a finished product ethyl lactate from the bottom of the refining tower, and returning the top material to the catalytic rectification tower.
2. The process for preparing ethyl lactate by rectification according to claim 1, wherein the lactide is selected from one or more of L lactide, D lactide or meso-lactide.
3. The rectification process for preparing ethyl lactate according to claim 1, wherein the ethanol is absolute ethanol.
4. The process for preparing ethyl lactate by rectification according to claim 3, wherein the lactide is added from the upper part of the catalytic rectification section of the catalytic rectification tower, the ethanol is added from the tower bottom, and after an azeotrope formed by the lactic acid and the water is obtained from the catalytic rectification section, the lactide enters a phase separator after being separated from the rectification section, so that the crude ester and the water phase are respectively obtained.
5. The rectification process for preparing ethyl lactate as claimed in claim 1, wherein the catalyst is a lewis acid or a tin salt.
6. The rectification process for preparing ethyl lactate according to claim 2, wherein the reaction temperature is 82-100 ℃ and the reaction time is 3-10 h.
7. The rectification process for preparing ethyl lactate according to claim 1, wherein the molar ratio of lactide to ethanol is 3: (2-10).
8. The process for preparing ethyl lactate by rectification according to claim 1, wherein the catalytic rectification tower is a packed tower, and the used packing is stainless steel random packing or regular packing.
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| CN202011492656.1A CN112552168A (en) | 2020-12-16 | 2020-12-16 | Process method for preparing ethyl lactate by rectification |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011492656.1A CN112552168A (en) | 2020-12-16 | 2020-12-16 | Process method for preparing ethyl lactate by rectification |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101906040A (en) * | 2010-08-23 | 2010-12-08 | 孝感市易生新材料有限公司 | Method for producing high-content and high-optical-purity lactate with two-step method |
| CN102675102A (en) * | 2012-04-27 | 2012-09-19 | 孝感市易生新材料有限公司 | Continuous production method of high-content high-optical-purity lactate |
| WO2013159347A1 (en) * | 2012-04-27 | 2013-10-31 | 孝感市易生新材料有限公司 | Method for continuously producing high-content high-optical-purity lactate |
| CN103922933A (en) * | 2014-04-22 | 2014-07-16 | 中国科学院长春应用化学研究所 | Preparation method of ethyl lactate |
| CN207169670U (en) * | 2017-08-02 | 2018-04-03 | 中国科学院长春应用化学研究所 | A kind of device of continuous production lactate |
-
2020
- 2020-12-16 CN CN202011492656.1A patent/CN112552168A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101906040A (en) * | 2010-08-23 | 2010-12-08 | 孝感市易生新材料有限公司 | Method for producing high-content and high-optical-purity lactate with two-step method |
| CN102675102A (en) * | 2012-04-27 | 2012-09-19 | 孝感市易生新材料有限公司 | Continuous production method of high-content high-optical-purity lactate |
| WO2013159347A1 (en) * | 2012-04-27 | 2013-10-31 | 孝感市易生新材料有限公司 | Method for continuously producing high-content high-optical-purity lactate |
| CN103922933A (en) * | 2014-04-22 | 2014-07-16 | 中国科学院长春应用化学研究所 | Preparation method of ethyl lactate |
| CN207169670U (en) * | 2017-08-02 | 2018-04-03 | 中国科学院长春应用化学研究所 | A kind of device of continuous production lactate |
Non-Patent Citations (2)
| Title |
|---|
| 张贞浴等: "D,L-丙交酯合成乳酸乙酯的研究", 《黑龙江大学自然科学学报》 * |
| 程能林: "《溶剂手册》", 31 May 1995 * |
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