CN112549625B - Full-automatic shaping pelleter of sildenafil citrate piece production usefulness - Google Patents
Full-automatic shaping pelleter of sildenafil citrate piece production usefulness Download PDFInfo
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- CN112549625B CN112549625B CN202011531658.7A CN202011531658A CN112549625B CN 112549625 B CN112549625 B CN 112549625B CN 202011531658 A CN202011531658 A CN 202011531658A CN 112549625 B CN112549625 B CN 112549625B
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- air hole
- membrane
- pedestal
- pressing
- hot
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/34—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses for coating articles, e.g. tablets
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
- B30B15/30—Feeding material to presses
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
- B30B15/32—Discharging presses
Abstract
The invention discloses a full-automatic forming and sheet-making machine for producing sildenafil citrate tablets, which comprises a pedestal, wherein the bottom of the pedestal is connected with a template in a sliding manner, the pedestal is provided with a first air hole and a second air hole, the template is provided with air holes corresponding to the first air hole and the second air hole, and the top of the pedestal is provided with two air pumps respectively communicated with the first air hole and the second air hole; a semi-elliptical groove communicated with the air hole is formed in the bottom of the template, a pressing plate moving up and down is installed below the pedestal, and a pressing block matched with the groove is arranged at the top of the pressing plate; a hot pressing plate which moves up and down is arranged below the pedestal; a first membrane is clamped in the groove, the first membrane is connected with a second membrane in a hot-pressing manner, and medicine particles are filled between the first membrane and the second membrane; the negative pressure structure is arranged on the basis of the upper pressing die and used for performing negative pressure adsorption and negative pressure removal, so that the tablet feeding, tabletting and discharging can be well completed, the sticking of tablets can be avoided, the yield of finished tablets is improved, and the tabletting rate is improved.
Description
Technical Field
The invention relates to the field of medicine processing, in particular to a full-automatic forming and tabletting machine for producing sildenafil citrate tablets.
Background
Sildenafil citrate is the name of medicine, the main component and the chemical name are 1- [ 4-ethoxy-3- [5- (6, 7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo [4, 3d ] pyrimidine) ] benzenesulfonyl ] -4-methylpiperazine citrate. The existing product is a blue diamond film coat, and is white powder after the film coat is removed. The oral medicine is used for treating penile Erectile Dysfunction (ED). It is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE 5).
The tablet needs to be coated before tabletting, the existing tabletting machine has the problems that the coating and cold pressing efficiency is low, and the tablet is easy to stick after cold pressing is finished, so that the prepared tablet is not easy to separate. The problem of sticking the die is solved by adopting an upward pressing method in the prior art, the self weight of the pressing sheet is utilized to make the pressing sheet fall, and the structure is easy to stick the die in actual use and is not easy to discharge and discharge.
Disclosure of Invention
The invention aims to solve the defects in the prior art and provides a full-automatic forming and tabletting machine for producing sildenafil citrate tablets.
In order to achieve the purpose, the invention adopts the following technical scheme:
a full-automatic forming pelleter for sildenafil citrate tablet production comprises a pedestal, wherein the bottom of the pedestal is connected with a template in a sliding manner, the pedestal is provided with a first air hole and a second air hole, the template is provided with air holes corresponding to the first air hole and the second air hole, and the top of the pedestal is provided with two air pumps respectively communicated with the first air hole and the second air hole; a semi-elliptical groove communicated with the air hole is formed in the bottom of the template, a pressing plate moving up and down is installed below the pedestal, and a pressing block matched with the groove is arranged at the top of the pressing plate; a hot pressing plate which moves up and down is arranged below the pedestal; the medicine bottle is characterized in that a first membrane is connected in the groove in a clamping mode, a second membrane is connected to the first membrane in a hot-pressing mode, and medicine particles are filled between the first membrane and the second membrane.
Preferably, the top of hot pressboard is provided with the hot-pressing structure, the hot-pressing structure include sliding connection be in the seat of pressing at hot pressboard top, be provided with spacing chamber in the seat of pressing, the top of pressing the seat is provided with the intercommunication the slide in spacing chamber, slide sliding connection has the depression bar, spacing intracavity is fixed with the second spring, the top fixed connection of second spring is in the bottom of depression bar.
Preferably, the top of hot pressboard is provided with the spout, press seat sliding connection in the spout, the spout internal fixation has first spring, the top fixed connection of first spring is in the bottom of pressing the seat.
Preferably, the positions of the pressure seat and the pressure rod correspond to the hot-pressing positions of the first membrane and the second membrane.
Preferably, the sliding block which moves up and down is connected in the first air hole in a sliding manner, two limiting blocks which are respectively located at the top end of the first air hole and the bottom end of the first air hole are fixedly connected in the first air hole, and the sliding block is located between the two limiting blocks.
Preferably, the pelleter further comprises an air cylinder, and the top output end of the air cylinder is fixedly connected to the bottom of the pressure plate.
Preferably, the pelleter further comprises a positioning column penetrating through the hot pressing plate and connected with the hot pressing plate in a sliding mode, and the second membrane and the medicine grains are placed on the top of the positioning column.
The invention has the beneficial effects that: the double-air-hole negative-pressure tablet feeding and discharging device is provided with the double air holes corresponding to the two stations, the negative-pressure structure is arranged on the basis of the upper pressing die to perform negative-pressure adsorption and negative-pressure removal, the tablet feeding, tablet making and discharging processes can be well completed, the efficiency is high, the probability of tablet sticking in tablet making is avoided to be as high as 99.6%, the yield of finished tablets can be improved, and the tablet making rate is improved.
Drawings
FIG. 1 is a front view of a pellet mill of the present invention;
FIG. 2 is an enlarged view of a portion A of FIG. 1;
fig. 3 is a partially enlarged view of fig. 1 at B.
Reference numbers in the figures: the device comprises a pedestal 1, a first air hole 11, a second air hole 12, a sliding block 111, a limiting block 112, a template 2, a groove 21, an air hole 22, a first membrane 3, a pressing plate 4, a pressing block 41, a cylinder 42, an air pump 5, a hot pressing plate 6, a positioning column 61, a sliding chute 62, a first spring 63, a hot pressing structure 7, a pressing seat 71, a limiting cavity 711, a slideway 712, a pressing rod 72, a second spring 73, medicine granules 8 and a second membrane 9.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to specific embodiments, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
Referring to fig. 1-3, a full-automatic forming and sheet-making machine for producing sildenafil citrate sheets comprises a pedestal 1, wherein the bottom of the pedestal 1 is connected with a template 2 in a sliding manner, the pedestal 1 is provided with a first air hole 11 and a second air hole 12, the template 2 is provided with an air hole 22 corresponding to the first air hole 11 and the second air hole 12, and the top of the pedestal 1 is provided with two air pumps 5 respectively communicated with the first air hole 11 and the second air hole 12; a semi-elliptical groove 21 communicated with the air hole 22 is formed in the bottom of the template 2, a pressing plate 4 moving up and down is installed below the pedestal 1, and a pressing block 41 matched with the groove 21 is arranged at the top of the pressing plate 4; a hot pressing plate 6 which moves up and down is arranged below the pedestal 1; the first diaphragm 3 is connected in the groove 21 in a clamping mode, the first diaphragm 3 is connected with the second diaphragm 9 in a hot-pressing mode, and the medicine particles 8 are arranged between the first diaphragm 3 and the second diaphragm 9.
In this embodiment, the top of the hot pressing plate 6 is provided with the hot pressing structure 7, the hot pressing structure 7 includes a pressing base 71 slidably connected to the top of the hot pressing plate 6, a limiting cavity 711 is provided in the pressing base 71, a slide 712 communicating the limiting cavity 711 is provided at the top of the pressing base 71, the slide 712 is slidably connected to a pressing rod 72, a second spring 73 is fixed in the limiting cavity 711, and the top end of the second spring 73 is fixedly connected to the bottom of the pressing rod 72.
In this embodiment, the top of the hot pressing board 6 is provided with a sliding slot 62, the pressing base 71 is slidably connected in the sliding slot 62, the first spring 63 is fixed in the sliding slot 62, and the top end of the first spring 63 is fixedly connected to the bottom of the pressing base 71.
In the present embodiment, the positions of the press base 71 and the press rod 72 correspond to the hot pressing positions of the first membrane 3 and the second membrane 9.
In this embodiment, a sliding block 111 which moves up and down is slidably connected in the first air hole 11, two limiting blocks 112 which are respectively located at the top end of the first air hole 11 and the bottom end of the first air hole 11 are fixedly connected in the first air hole 11, and the sliding block 111 is located between the two limiting blocks 112.
In this embodiment, the pelleter of the present invention further comprises an air cylinder 42, and the top output end of the air cylinder 42 is fixedly connected to the bottom of the pressure plate 4.
In this embodiment, the pelleter further includes a positioning post 61 penetrating through the hot press plate 6 and slidably connected to the hot press plate 6, and the second membrane 9 and the drug granules 8 are disposed on the top of the positioning post 61.
The working principle is as follows: firstly, the method comprises the following steps: the template 2 moves on the pedestal 1, firstly, the template reaches a first station, the air holes 22 are correspondingly combined with the first air holes 11, the first membrane 3 is placed between the pressing block 41 and the template 2, and the air cylinder 42 drives the pressing plate 4 and the pressing block 41 to press upwards, so that the first membrane 3 deforms, and the processing of the first membrane 3 is completed;
II, secondly: the air pump 5 works to pump out air in the first air hole 11, negative pressure is formed in the air hole 22, and the first membrane 3 is adsorbed in the groove 21, so that the first membrane 3 can stably reach the second station, and the subsequent processing is completed; on this basis, set up slider 111 and stopper 112, the removal of slider 111 in first wind hole 11 can stabilize wind-force, avoids the excessive work of air pump 5 to lead to first diaphragm 3 to take place to warp, and stopper 112 then plays the effect of restriction slider 111.
Thirdly, the method comprises the following steps: template 2 reachs the second station, gas pocket 22 corresponds the intercommunication with second wind hole 12, need to guarantee the reference column 61 of bottom and the second diaphragm 9 at reference column 61 top this moment, medicine grain 8 all targets in place (is located first diaphragm 3 under), control hot pressboard 6 pushes up, medicine grain 8 fills into first diaphragm 3 in, when fixed first diaphragm 3 position, accomplish the material loading, hot pressboard 6 continues to push up, depression bar 72 at first contacts with hot pressing surface, promote the deformation of second spring 73, press seat 71 again with hot pressing surface contact, promote first spring 63 to warp, all play the effect of hot pressing buffering, double spring structure simultaneously, the sticky piece condition that also can effectively avoid direct crimping to lead to takes place.
Fourthly, the method comprises the following steps: after the hot pressing is completed, the hot pressing plate 6 returns to complete the medicine tabletting, the tablet is pressed downwards under the action of the weight of the tablet, and the tablet is blown into the second air hole 12 through the air pump 5 to drop from the groove 21.
In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like, indicate orientations and positional relationships based on those shown in the drawings, and are used only for convenience of description and simplicity of description, and do not indicate or imply that the equipment or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be considered as limiting the present invention.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (6)
1. The full-automatic forming and sheet-making machine for sildenafil citrate sheet production is characterized by comprising a pedestal (1), wherein the bottom of the pedestal (1) is connected with a template (2) in a sliding manner, a first air hole (11) and a second air hole (12) are formed in the pedestal (1), air holes (22) corresponding to the first air hole (11) and the second air hole (12) are formed in the template (2), and two air pumps (5) respectively communicated with the first air hole (11) and the second air hole (12) are mounted at the top of the pedestal (1); a semi-elliptical groove (21) communicated with the air hole (22) is formed in the bottom of the template (2), a pressing plate (4) moving up and down is installed on one side of the pedestal (1) and located below a first station of the template (2), and a pressing block (41) matched with the groove (21) is arranged at the top of the pressing plate (4); a hot pressing plate (6) moving up and down is arranged on the other side of the pedestal (1) and below the second station of the template (2); a first membrane (3) is connected in the groove (21) in a clamping manner, a second membrane (9) is connected to the first membrane (3) in a hot-pressing manner, and medicine particles (8) are filled between the first membrane (3) and the second membrane (9);
the positioning column (61) penetrates through the hot pressing plate (6) and is in sliding connection with the hot pressing plate (6), and the second membrane (9) and the medicine particles (8) are all placed at the top of the positioning column (61).
2. The full-automatic molding and sheet-making machine of sildenafil citrate tablet production usefulness according to claim 1, characterized in that, the top of hot pressboard (6) is provided with hot-pressing structure (7), hot-pressing structure (7) include sliding connection in press seat (71) at hot pressboard (6) top, be provided with spacing chamber (711) in pressing seat (71), the top of pressing seat (71) is provided with intercommunication slide (712) of spacing chamber (711), slide (712) sliding connection has depression bar (72), spacing chamber (711) internal fixation has second spring (73), the top fixed connection of second spring (73) is in the bottom of depression bar (72).
3. The full-automatic sildenafil citrate tablet forming machine as claimed in claim 2, wherein a sliding groove (62) is formed in the top of the hot pressing plate (6), the pressing seat (71) is slidably connected in the sliding groove (62), a first spring (63) is fixed in the sliding groove (62), and the top end of the first spring (63) is fixedly connected to the bottom of the pressing seat (71).
4. The full-automatic sildenafil citrate tablet molding machine according to claim 3, wherein the positions of the press seat (71) and the press rod (72) correspond to the hot pressing positions of the first membrane sheet (3) and the second membrane sheet (9).
5. The full-automatic forming and sheet-making machine for sildenafil citrate tablet production according to claim 1, wherein a slide block (111) which moves up and down is slidably connected in the first air hole (11), two limit blocks (112) which are respectively positioned at the top end of the first air hole (11) and the bottom end of the first air hole (11) are fixedly connected in the first air hole (11), and the slide block (111) is positioned between the two limit blocks (112).
6. The full-automatic sildenafil citrate tablet forming machine according to claim 1, further comprising an air cylinder (42), wherein the top output end of the air cylinder (42) is fixedly connected to the bottom of the pressure plate (4).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011531658.7A CN112549625B (en) | 2020-12-22 | 2020-12-22 | Full-automatic shaping pelleter of sildenafil citrate piece production usefulness |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011531658.7A CN112549625B (en) | 2020-12-22 | 2020-12-22 | Full-automatic shaping pelleter of sildenafil citrate piece production usefulness |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112549625A CN112549625A (en) | 2021-03-26 |
| CN112549625B true CN112549625B (en) | 2022-07-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011531658.7A Active CN112549625B (en) | 2020-12-22 | 2020-12-22 | Full-automatic shaping pelleter of sildenafil citrate piece production usefulness |
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Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB474409A (en) * | 1935-05-08 | 1937-11-01 | Sharp & Dohme Inc | Improvements in or relating to medicinal capsules or coated pills |
| US2513852A (en) * | 1946-12-26 | 1950-07-04 | Alfonso M Donofrio | Method for encapsulating |
| CH295829A (en) * | 1950-07-19 | 1954-01-15 | American Cyanamid Co | Method and machine for the production of plastic capsules filled with liquid. |
| CN1109627C (en) * | 2000-01-26 | 2003-05-28 | 依钟康 | Soft capsule for packing different material and its production equipment and method |
| GB0211620D0 (en) * | 2002-05-21 | 2002-07-03 | Bioprogress Technology Ltd | Powder compaction and enrobing |
| GB0412495D0 (en) * | 2004-06-04 | 2004-07-07 | Bioprogress Technology Ltd | Capsules derived from asymmetrical production |
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2020
- 2020-12-22 CN CN202011531658.7A patent/CN112549625B/en active Active
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| CN112549625A (en) | 2021-03-26 |
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