CN1125338C - Blood separating colloid - Google Patents
Blood separating colloid Download PDFInfo
- Publication number
- CN1125338C CN1125338C CN 00115944 CN00115944A CN1125338C CN 1125338 C CN1125338 C CN 1125338C CN 00115944 CN00115944 CN 00115944 CN 00115944 A CN00115944 A CN 00115944A CN 1125338 C CN1125338 C CN 1125338C
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- China
- Prior art keywords
- blood
- blood separating
- separating colloid
- silicon dioxide
- separating
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Abstract
The present invention relates to blood separating gel which is a product obtained through the reaction of a hydrocarbon compound with macromolecules and silicon dioxide at the temperature of 100 to 200 DEG C. The specific weight D20 is from 1.04 to 1.05, and the viscosity is from 20 to 80*10<4>CP at 20 DEG C. The blood separating gel has the advantages of few raw materials and low cost. The blood separating gel is added to a blood sampling tube after sterilization and coagulation promotion, and thus, serum is separated from blood cells. Large quantities of clinical experiments prove that the separating effect is good and the separating cost is low.
Description
The present invention relates to a kind of clinical examination process that is used for, with serum in the blood and blood cell separation gel.
In clinical examination, adopt blood separating colloid that the serum in the blood in the heparin tube is separated with blood cell usually.Existing blood separating colloid has a lot, the blood separating colloid that is distributed as U.S. Pat P3.780.935, USP4.018.564, USP4.387.031, be to prepare with silicone oil, silicon dioxide, polyvinyl chloride powder, after they place a period of time, viscosity can change, thereby the quality of influence separation.USP4.310.430, USP4.426.290 have announced the blood separating colloid that is mixed with by tygon hydrocarbon maleate and silicon dioxide." a kind of serum separation gel and adopt preparation method to pipe " (application number 93112002.0) disclosed serum separation gel is by silicon rubber, and macromolecular hydrocarbon, mercapto glue are formulated.Wherein the silicon rubber valency is expensive, causes the cost height of blood separating colloid.It adopts dewatering silica gel is raw material, needs to have the carrier method of the silica flour of necessarily required silicon dioxide gained behind the bowl mill mill with preparative chromatography, obtains giving preparation again behind the dewatering silica gel by preparation with trimethyl chlorosilane.
Purpose of the present invention aims to provide the blood separating colloid that a kind of cost is low, can directly directly prepare with silicon dioxide.
The implementation of the object of the invention is, blood separating colloid be by weight ratio be the silicon dioxide of the macromolecular hydrocarbon of 70-80% and 20-30% in 100 ℃-200 ℃ products of reaction down, its proportion is D
201.04-1.05, viscosity (20 ℃) is 20-80 * 10
4CP.
Wherein macromolecular hydrocarbon comprises: 20
#-60
#In machinery oil, whiteruss, the polyisobutylene one or more.
The present invention only adopts inexpensive macromolecular hydrocarbon and silicon dioxide, after mixing in required ratio, reacts 1-3 hour down at 100 ℃-200 ℃, promptly gets blood separating colloid.This blood separating colloid production technology is simple, cost is low, preservation effect is good.
This blood glue carries out clinical practice in the court clinical laboratory, blood effect separator well.Clinical laboratory of People's Hospital, Shiyan City has carried out preliminary clinical testing with this blood separating colloid, and the result shows that the short effect with fixed attention and the blood separation of this blood separating colloid are effective, and be close with external like product.
Enumerate the specific embodiment of the invention below:
Example 1, to get weight ratio be 30% polyisobutylene, 50% whiteruss mixing, 100 ℃-200 ℃ reactions 3 hours down, adds 20% silicon dioxide, fully stir this blood separating colloid.During check, this blood separation of 0.5-1g liquid is added in the heparin tube, in heparin tube, add blood sample, after the blood coagulation, in 1000G centrifugal 10 minutes, promptly between serum and clot, form separation layer after the separation.
Example 2, get weight ratio be 30% polyisobutylene, 30% 20
#-60
#Machinery oil adds 30% silicon dioxide 100 ℃-200 ℃ down reactions 3 hours, fully stir this blood separating colloid.Application is with example 1.
Claims (1)
1, blood separating colloid, it is characterized in that be by weight ratio be the silicon dioxide of the macromolecular hydrocarbon of 70-80% and 20-30% in 100 ℃-200 ℃ products of reflection down, its proportion is D
201.04-1.05, viscosity is 20-80 * 10 20 ℃ the time
4CP, wherein macromolecular hydrocarbon comprises: 20
#-60
#In machinery oil, whiteruss, the polyisobutylene one or more.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00115944 CN1125338C (en) | 2000-08-08 | 2000-08-08 | Blood separating colloid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00115944 CN1125338C (en) | 2000-08-08 | 2000-08-08 | Blood separating colloid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1281145A CN1281145A (en) | 2001-01-24 |
| CN1125338C true CN1125338C (en) | 2003-10-22 |
Family
ID=4585384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00115944 Expired - Fee Related CN1125338C (en) | 2000-08-08 | 2000-08-08 | Blood separating colloid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1125338C (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100341599C (en) * | 2005-09-19 | 2007-10-10 | 陈平谦 | Inertia glue |
| EP2360470A4 (en) * | 2008-11-07 | 2013-01-02 | Hitachi Chemical Co Ltd | Blood serum or blood plasma separating material and blood-collecting tube using same |
| CN101570637B (en) * | 2009-06-02 | 2011-12-14 | 广州标美药用辅料有限公司 | Organic silicon separation gel and preparation method and application thereof |
| CN102309870A (en) * | 2011-06-17 | 2012-01-11 | 上海科华检验医学产品有限公司 | Blood separation gel used for blood collection vessel and preparation method thereof |
| CN102212514B (en) * | 2011-06-17 | 2012-10-24 | 上海科华检验医学产品有限公司 | Blood coagulant for blood collection container |
| CN102872616B (en) * | 2012-09-26 | 2014-10-01 | 成都众睿达科技有限公司 | Blood separating gel and preparation method thereof |
| CN103293049A (en) * | 2013-05-27 | 2013-09-11 | 苏州扬清芯片科技有限公司 | Serum separation method and serum separation device |
| CN103585787A (en) * | 2013-11-15 | 2014-02-19 | 中国科学院长春应用化学研究所 | Application of suspension isolation balls in separation gel blood collection tube |
| US10677778B2 (en) * | 2015-06-10 | 2020-06-09 | Sekisui Medical Co., Ltd. | Serum- or plasma-separating composition, blood-test container, and method of stabilizing serum- or plasma-separating composition |
| CN107233751A (en) * | 2017-06-30 | 2017-10-10 | 常州亚环环保科技有限公司 | A kind of stable low viscosity blood separating colloid and preparation method thereof |
-
2000
- 2000-08-08 CN CN 00115944 patent/CN1125338C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1281145A (en) | 2001-01-24 |
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