CN112516370A - Medical femoral head repair pad and preparation method thereof - Google Patents
Medical femoral head repair pad and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/64—Use of materials characterised by their function or physical properties specially adapted to be resorbable inside the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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Abstract
The invention discloses a medical femoral head repair pad and a preparation method thereof, wherein the preparation method comprises the steps of material selection, foreign protein removal, virus inactivation, collagen degreasing, casing extension, chitosan atomization, dressing shaping, dressing solidification, cutting, inspection, packaging, sterilization and the like; the chitosan in the invention has antibacterial property, can resist microbial infection, induce tissue regeneration, accelerate wound healing and does not cause any inflammatory reaction in the tissue; the collagen has the functions of hemostasis and repair, bioabsorbability and cell adhesion, promotes the formation of new cells and promotes the repair of femoral head; the product has low antigenicity and good compatibility with human tissues, is automatically coordinated and absorbed by enzyme and body fluid, has stable absorption period, and is finally completely absorbed by human beings; the femoral head repair pad prepared by the method has the characteristics of uniform texture, good elasticity, high transparency, good air permeability, good biocompatibility, capability of being absorbed by organisms, small toxic and side effects and the like.
Description
Technical Field
The invention relates to the technical field of biomedicine, in particular to a medical femoral head repair pad and a preparation method thereof.
Background
Femoral head necrosis is a common and difficult bone disease and a common cause of disability in young and strong years. The number of patients with femoral head necrosis in the United states is reported to be 30-60 ten thousand, the number of new femoral head necrosis in China is 15-30 ten thousand every year, and the total number of patients needing treatment is 500-750 ten thousand. The domestic method for treating ischemic necrosis of femoral head includes weight control, core decompression, various osteotomies, bone grafting with vascular anastomosis, bone grafting without vascular anastomosis, artificial joint replacement, etc. The article of Chenjiaping et al, finite element analysis of the effect of the cavity generated after the medullary decompression operation on the stress of the femoral head, shows that the shape of the cavity caused by the medullary decompression operation has a great effect on the stress concentration, and the analysis result provides a certain reference basis for the medullary decompression operation. The elasto-plastic finite element analysis result of the polyethylene lining stress after the total hip joint replacement by the strict precious people and the like shows that the polyethylene lining in the total hip joint prosthesis can be damaged after the operation, and high-load activities such as going upstairs and the like are avoided or reduced after the operation. The other treatment scheme is that the ischemic necrosis of the femoral head is treated by strengthening the bone bolt, and the three-dimensional finite element analysis is carried out on the treatment scheme by people like Zhongchang, and the results show that the implantation of the bone bolt can improve the bone strength of the femoral necrosis area, but the effect can be optimal only when the bone bolt is placed in the direction of the pressure bone trabecula.
The invention takes casing collagen line as raw material, is a pure biological product, and the medical femoral head repair pad prepared by extracting collagen as raw material can be completely absorbed by human body, has no toxic or side effect, easy absorption, good biological safety, good air permeability, uniform dressing thickness, white and transparent material, rapid healing of femoral head tissue of a patient, and the wound surface can be basically recovered as before, thus being a green and safe wound repair pad. The development of a novel, safer and more clinically-required medical femoral head repair pad meets the national encouragement of bio-industry guidance and bio-industry upgrading trend. The produced medical femoral head repair pad taking casing collagen as a raw material has originality in the global scope, and has profound economic and social benefits for the aspects of promoting the industrial upgrading of the medical appliance industry in China, improving the clinical repair safety of patients, enlarging exports and earning foreign exchange, and the like.
Disclosure of Invention
The invention aims to provide a medical femoral head repair pad and a preparation method thereof, and aims to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme: a preparation method of a medical femoral head repair pad comprises the following steps:
(1) selecting materials: selecting casings qualified by quarantine, and cutting small intestine parts;
(2) removing foreign protein: cleaning the inner wall of the small intestine casing, and separating and dropping intestinal chorion, mucosa and serosa in the casing by using a special tool;
(3) virus inactivation: soaking the casing with foreign protein removed in edible hydrogen peroxide solution and cleaning;
(4) degreasing collagen: cleaning the casing with clear water, soaking the casing in a sodium chloride solution, and then separating and cutting fat in the casing collagen to obtain a relatively pure collagen tissue;
(5) casing extension: cutting the casing into pieces, and then extending the pieces to a set length and width by using extension equipment;
(6) atomizing chitosan: adding excessive chitosan into acetic acid solution, fully stirring to prepare chitosan saturated solution, uniformly spraying the chitosan saturated solution on the surface of the sausage casing, standing, and repeating the spraying and standing operations for multiple times;
(7) dressing shaping: covering the extended casing slice by a flat clamp to shape;
(8) curing the dressing: dehydrating and solidifying the mixture in a temperature control chamber under the conditions of gradually increasing the temperature and gradually reducing the humidity;
(9) cutting and checking: under a microscope operating table, detecting the transparency, the uniformity and the existence of impurities of the dressing, and cutting the casing slice treated by the process into a semi-finished product according to the size and the thickness required by femoral head repair;
(10) packaging and sterilizing: the medical femoral head repair pad is vacuum-packaged in a clean workshop with the grade of not less than 10 ten thousand and then is put into a sterilization room to be sterilized by cobalt-60 gamma ray radiation.
Preferably, the specific operation of virus inactivation is as follows: soaking the casing with foreign protein removed in 5-7% edible hydrogen peroxide solution at 40-44 deg.C for 13-17 hr, and washing with purified water for 3-5 times.
Preferably, the concentration of the sodium chloride solution in the collagen degreasing process is 14-16%, and the soaking time is 70-78 minutes.
Preferably, the chitosan atomization is specifically operated as: uniformly spraying the chitosan saturated solution with the temperature of 36-48 ℃ on the surface of the sausage casing, standing for 44-56 minutes, then spraying and standing, and repeating the steps for 3-5 times.
Preferably, the rate of temperature rise in curing of the dressing is 0.5-0.9 ℃/h, the humidity is reduced by 4-6% per hour, the temperature is raised to 53 ℃ at the maximum, and the humidity is reduced to 8% at the minimum.
Has the advantages that: compared with the prior art, the chitosan has antibacterial activity, can resist microbial infection, induce tissue regeneration and accelerate wound healing, and does not cause any inflammatory reaction in tissues; the collagen has the functions of hemostasis and repair, bioabsorbability and cell adhesion, promotes the formation of new cells and promotes the repair of femoral head; due to the excellent biocompatibility of the chitosan and the collagen material, the product has low antigenicity and good compatibility with human tissues, is automatically coordinated and absorbed by enzyme and body fluid, has stable absorption period, and is finally completely absorbed by human beings.
The medical femoral head repair pad prepared by the method has the characteristics of uniform texture, good elasticity, high transparency, good air permeability, good biocompatibility, capability of being absorbed by organisms, small toxic and side effects and the like. The repair pad is completely absorbed, has small tissue adverse reaction, is not easy to be infected with bacteria, and can avoid infection.
Detailed Description
In order that the above objects, features and advantages of the present invention can be more clearly understood, the present invention will be further described with reference to the following examples. It should be noted that the embodiments and features of the embodiments of the present application may be combined with each other without conflict.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, however, the present invention may be practiced in other ways than those specifically described herein, and thus the present invention is not limited to the specific embodiments of the present disclosure.
Example 1
The preparation method of the medical femoral head repair pad according to the embodiment comprises the following steps:
(1) selecting casings qualified by quarantine, and cutting small intestine parts;
(2) removing foreign protein: cleaning the inner wall of the small intestine casing, and separating and dropping intestinal chorion, mucosa and serosa in the casing by using a special tool;
(3) virus inactivation: soaking the casing with foreign protein removed in 5% edible hydrogen peroxide solution at 40 deg.C for 13 hr, and washing with purified water for 3 times.
(4) Degreasing collagen: cleaning the casing with clear water, soaking the casing in a sodium chloride solution with the concentration of 14% for 70 minutes, and then separating and cutting off fat in the casing collagen to obtain a relatively pure collagen tissue;
(5) casing extension: cutting the casing into pieces, and then extending the pieces to a set length and width by using extension equipment;
(6) atomizing chitosan: adding excessive chitosan into acetic acid solution, fully stirring to prepare saturated solution of chitosan, uniformly spraying the saturated solution of chitosan with the temperature of 36 ℃ on the surface of the sausage casing, waiting for 44 minutes, then spraying, and repeating the step for 3 times;
(7) dressing shaping: and covering the extended sausage casing sheets by using a flat fixture to shape the extended sausage casing sheets.
(8) Curing the dressing: dehydrating and curing the materials in a temperature control chamber under the conditions of gradually increasing the temperature and gradually decreasing the humidity, wherein the temperature increasing rate is 0.5 ℃/h, the humidity is decreased by 4 percent per hour, the temperature is increased to 53 ℃ at most, and the humidity is decreased to 8 percent at least;
(9) cutting and checking: checking the transparency, the uniformity and the existence of impurities of the dressing under a microscope operating table, and cutting the dressing into semi-finished products with different sizes and thicknesses;
(10) packaging and sterilizing: the medical femoral head repair pad is vacuum-packaged in a clean workshop with the grade of not less than 10 ten thousand and then is put into a sterilization room to be sterilized by cobalt-60 gamma ray radiation.
Example 2
The preparation method of the medical femoral head repair pad according to the embodiment comprises the following steps:
(1) selecting casings qualified by quarantine, and cutting small intestine parts;
(2) removing foreign protein: cleaning the inner wall of the small intestine casing, and separating and dropping intestinal chorion, mucosa and serosa in the casing by using a special tool;
(3) virus inactivation: soaking the casing with foreign protein removed in 6% edible hydrogen peroxide solution at 42 deg.C for 15 hr, and washing with purified water for 4 times.
(4) Degreasing collagen: cleaning the sausage casing with clear water, soaking the sausage casing in 15% sodium chloride solution for 74 minutes, and then separating and cutting off fat in the collagen of the sausage casing to obtain a relatively pure collagen tissue;
(5) casing extension: cutting the casing into pieces, and then extending the pieces to a set length and width by using extension equipment;
(6) atomizing chitosan: adding excessive chitosan into acetic acid solution, fully stirring to prepare saturated solution of chitosan, uniformly spraying the saturated solution of chitosan with the temperature of 42 ℃ on the surface of the sausage casing, waiting for 50 minutes, then spraying, and repeating the step for 4 times;
(7) dressing shaping: and covering the extended sausage casing sheets by using a flat fixture to shape the extended sausage casing sheets.
(8) Curing the dressing: dehydrating and curing the materials in a temperature control chamber under the conditions of gradually increasing the temperature and gradually decreasing the humidity, wherein the temperature increasing rate is 0.7 ℃/h, the humidity is decreased by 5 percent per hour, the temperature is increased to 53 ℃ at most, and the humidity is decreased to 8 percent at least;
(9) cutting and checking: checking the transparency, the uniformity and the existence of impurities of the dressing under a microscope operating table, and cutting the dressing into semi-finished products with different sizes and thicknesses;
(10) packaging and sterilizing: the medical femoral head repair pad is vacuum-packaged in a clean workshop with the grade of not less than 10 ten thousand and then is put into a sterilization room to be sterilized by cobalt-60 gamma ray radiation.
Example 3
The preparation method of the medical femoral head repair pad according to the embodiment comprises the following steps:
(1) selecting casings qualified by quarantine, and cutting small intestine parts;
(2) removing foreign protein: cleaning the inner wall of the small intestine casing, and separating and dropping intestinal chorion, mucosa and serosa in the casing by using a special tool;
(3) virus inactivation: soaking the casing with foreign protein removed in 7% edible hydrogen peroxide solution at 44 deg.C for 17 hr, and washing with purified water for 5 times.
(4) Degreasing collagen: cleaning the sausage casing with clean water, soaking the sausage casing in a sodium chloride solution with the concentration of 16% for 78 minutes, and then separating and cutting fat in collagen of the sausage casing to obtain a relatively pure collagen tissue;
(5) casing extension: cutting the casing into pieces, and then extending the pieces to a set length and width by using extension equipment;
(6) atomizing chitosan: adding excessive chitosan into acetic acid solution, fully stirring to prepare saturated solution of chitosan, uniformly spraying the saturated solution of chitosan with the temperature of 48 ℃ on the surface of the sausage casing, waiting for 56 minutes, then spraying, and repeating the step for 5 times;
(7) dressing shaping: and covering the extended sausage casing sheets by using a flat fixture to shape the extended sausage casing sheets.
(8) Curing the dressing: dehydrating and curing the materials in a temperature control chamber under the conditions of gradually increasing the temperature and gradually decreasing the humidity, wherein the temperature increasing rate is 0.9 ℃/h, the humidity is decreased by 6 percent per hour, the temperature is increased to 53 ℃ at the maximum, and the humidity is decreased to 8 percent at the minimum;
(9) cutting and checking: checking the transparency, the uniformity and the existence of impurities of the dressing under a microscope operating table, and cutting the dressing into semi-finished products with different sizes and thicknesses;
(10) packaging and sterilizing: the medical femoral head repair pad is vacuum-packaged in a clean workshop with the grade of not less than 10 ten thousand and then is put into a sterilization room to be sterilized by cobalt-60 gamma ray radiation.
According to the medical femoral head repair pad and the preparation method thereof provided by the invention, the used chitosan has antibacterial property, can resist microbial infection, induce tissue regeneration and accelerate wound healing, and does not cause any inflammatory reaction in the tissue; the collagen has the functions of hemostasis and repair, bioabsorbability and cell adhesion, promotes the formation of new cells and promotes the repair of femoral head; due to the excellent biocompatibility of the chitosan and the collagen material, the product has low antigenicity and good compatibility with human tissues, is automatically coordinated and absorbed by enzyme and body fluid, has stable absorption period, and is finally completely absorbed by human beings.
The medical femoral head repair pad prepared by the method has the characteristics of uniform texture, good elasticity, high transparency, good air permeability, good biocompatibility, capability of being absorbed by organisms, small toxic and side effects and the like. The repair pad is completely absorbed, has small tissue adverse reaction, is not easy to be infected with bacteria, and can avoid infection.
The above description is only a preferred embodiment of the present invention, and not intended to limit the present invention in other forms, and any person skilled in the art may apply the above modifications or changes to the equivalent embodiments with equivalent changes, without departing from the technical spirit of the present invention, and any simple modification, equivalent change and change made to the above embodiments according to the technical spirit of the present invention still belong to the protection scope of the technical spirit of the present invention.
Claims (6)
1. The preparation method of the medical femoral head repair pad is characterized by comprising the following steps:
(1) selecting materials: selecting casings qualified by quarantine, and cutting small intestine parts;
(2) removing foreign protein: cleaning the inner wall of the small intestine casing, and separating and dropping intestinal chorion, mucosa and serosa in the casing by using a special tool;
(3) virus inactivation: soaking the casing with foreign protein removed in edible hydrogen peroxide solution and cleaning;
(4) degreasing collagen: cleaning the casing with clear water, soaking the casing in a sodium chloride solution, and then separating and cutting fat in the casing collagen to obtain a relatively pure collagen tissue;
(5) casing extension: cutting the casing into pieces, and then extending the pieces to a set length and width by using extension equipment;
(6) atomizing chitosan: adding excessive chitosan into acetic acid solution, fully stirring to prepare chitosan saturated solution, uniformly spraying the chitosan saturated solution on the surface of the sausage casing, standing, and repeating the spraying and standing operations for multiple times;
(7) dressing shaping: covering the extended casing slice by a flat clamp to shape;
(8) curing the dressing: dehydrating and solidifying the mixture in a temperature control chamber under the conditions of gradually increasing the temperature and gradually reducing the humidity;
(9) cutting and checking: under a microscope operating table, detecting the transparency, the uniformity and the existence of impurities of the dressing, and cutting the casing slice treated by the process into a semi-finished product according to the size and the thickness required by femoral head repair;
(10) packaging and sterilizing: the medical femoral head repair pad is vacuum-packaged in a clean workshop with the grade of not less than 10 ten thousand and then is put into a sterilization room to be sterilized by cobalt-60 gamma ray radiation.
2. The method for preparing a medical femoral head repair pad according to claim 1, wherein the specific operation of virus inactivation is as follows: soaking the casing with foreign protein removed in 5-7% edible hydrogen peroxide solution at 40-44 deg.C for 13-17 hr, and washing with purified water for 3-5 times.
3. The method for preparing a medical femoral head repair pad according to claim 1, wherein the concentration of the sodium chloride solution in the collagen defatting process is 14-16%, and the soaking time is 70-78 minutes.
4. The method for preparing a medical femoral head repair pad according to claim 1, wherein the chitosan atomization operation comprises: uniformly spraying the chitosan saturated solution with the temperature of 36-48 ℃ on the surface of the sausage casing, standing for 44-56 minutes, then spraying and standing, and repeating the steps for 3-5 times.
5. The method for preparing a medical femoral head repair pad according to claim 1, wherein the rate of temperature increase in curing the dressing is 0.5-0.9 ℃/h, the humidity is reduced by 4-6% per hour, the temperature is increased to 53% at the maximum, and the humidity is reduced to 8% at the minimum.
6. A medical femoral head repair pad obtained by the method for preparing a medical femoral head repair pad according to any one of claims 1 to 5.
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| CN202011422909.8A CN112516370A (en) | 2020-12-08 | 2020-12-08 | Medical femoral head repair pad and preparation method thereof |
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| CN202011422909.8A CN112516370A (en) | 2020-12-08 | 2020-12-08 | Medical femoral head repair pad and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491920A (en) * | 2014-12-19 | 2015-04-08 | 山东博达医疗用品有限公司 | Method for preparing absorbable suture |
| CN104524626A (en) * | 2014-12-19 | 2015-04-22 | 山东博达医疗用品有限公司 | Absorbable collagen protein snare line and preparation method thereof |
| CN111905140A (en) * | 2020-05-26 | 2020-11-10 | 山东省科学院新材料研究所 | Multifunctional absorbable collagen medical suture and preparation method thereof |
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2020
- 2020-12-08 CN CN202011422909.8A patent/CN112516370A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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Application publication date: 20210319 |