CN112515666B - Wearable structure for biological detection - Google Patents
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- CN112515666B CN112515666B CN202011319909.5A CN202011319909A CN112515666B CN 112515666 B CN112515666 B CN 112515666B CN 202011319909 A CN202011319909 A CN 202011319909A CN 112515666 B CN112515666 B CN 112515666B
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
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Abstract
The utility model relates to a wearable structure for biological detection, gather the piece including support and tissue fluid, the support includes central zone and a plurality of linking arm, a plurality of linking arms set up along central zone's circumference interval, the first end and the central zone of linking arm are connected, the second end of linking arm can be directly or indirectly fixed at the tissue surface that awaits measuring, the central zone is equipped with the printing opacity runner, the printing opacity runner is gathered a intercommunication with tissue fluid, at least partial linking arm is when moving along with the deformation on the tissue surface that awaits measuring, the central zone that drives the support is to keeping away from the direction lifting on the tissue surface that awaits measuring. The central area of the support can be lifted to form an out-of-plane space for detecting light incidence, and the composition of tissue fluid can be analyzed by detecting the light signal emitted through the light-transmitting flow channel, so that the detection is quicker and more accurate.
Description
Technical Field
The application relates to the technical field of biological detection, in particular to a wearable structure for biological detection.
Background
The tissue fluid is a fluid existing among cells, the cells are infiltrated in the tissue fluid and can exchange substances with the tissue fluid, the tissue fluid is a necessary condition for the metabolism of common cells, and the condition of a human body can be monitored in real time by detecting the component change process of the tissue fluid. Optical detection is a detection method with higher sensitivity in biological detection, and because the construction of the optical path of detection light is involved, the tissue fluid generally needs to be taken out to a specific device for detection, so that the detection efficiency is low, and meanwhile, the tissue fluid is easy to be polluted after being taken out, so that the accuracy of the detection result is influenced.
Disclosure of Invention
To above-mentioned technical problem, the application provides a wearable structure for biological detection, can utilize wearable structure to carry out the interstitial fluid and detect, detect more fast, accurate.
For solving above-mentioned technical problem, the application provides a wearable structure for biological detection, gather the piece including support and tissue fluid, the support includes central zone and a plurality of linking arm, a plurality of linking arms are followed central zone's circumference interval sets up, the first end of linking arm with central zone connects, the second end of linking arm can be directly or indirectly fixed at the tissue surface that awaits measuring, central zone is equipped with the printing opacity runner, the printing opacity runner with tissue fluid gathers a intercommunication, at least part the linking arm is followed during the deformation and the motion of the tissue surface that awaits measuring, drive the support central zone is to keeping away from the direction lifting on the tissue surface that awaits measuring.
Optionally, it is a plurality of the linking arm includes at least one and is equipped with the entry runner the linking arm with at least one is equipped with exit runner the linking arm, entry runner's both ends respectively with the runner entry of printing opacity runner the piece intercommunication is gathered to the tissue fluid, exit runner's both ends respectively with the runner export of printing opacity runner the tissue fluid export intercommunication of support.
Optionally, the tissue surface patch further comprises a flexible substrate, the second end of the connecting arm is fixed to the first side of the flexible substrate, and a partial area or a whole area of the second side of the flexible substrate is used for being adhered to the tissue surface to be detected.
Optionally, the tissue fluid collecting member is a microneedle structure fixed on the second side of the flexible substrate; and/or the connecting arm is curved or linear.
Optionally, the light-transmitting flow channel includes a plurality of annular flow channels and a plurality of connecting flow channels, the annular flow channels are different in radius and concentrically arranged, and the connecting flow channels communicate with the adjacent annular flow channels.
Optionally, a modification material layer is disposed on a sidewall surface of at least a partial region of the light-transmitting flow channel, and the modification material layer is used for enriching specific components in interstitial fluid.
Optionally, the modification material layer is a carbon dioxide nanosphere layer; and/or the modification material layer is a metal electrode layer of surface modification cloth Lu Shilan and glucose oxidase, and the metal electrode layer is connected with an external electrode.
Optionally, the width of the light-transmitting flow channel is 0.1-10 μm.
Optionally, the light-transmitting flow channel is a closed flow channel, and the top wall and the bottom wall of the light-transmitting flow channel are light-transmitting.
Optionally, the cover further includes a cover body, the top of the light-transmitting flow channel is open, the bottom wall of the light-transmitting flow channel is light-transmitting, the cover body includes at least one openable portion connected to at least part of the connecting arm, the openable portion covers the light-transmitting flow channel when closed, and the openable portion is opened when the central area of the support is lifted.
The utility model provides a wearable structure for biological detection, gather the piece including support and tissue fluid, the support includes central zone and a plurality of linking arm, a plurality of linking arms set up along central zone's circumference interval, the first end and the central zone of linking arm are connected, the second end of linking arm can be directly or indirectly fixed at the tissue surface that awaits measuring, the central zone is equipped with the printing opacity runner, the printing opacity runner is gathered a intercommunication with tissue fluid, at least partial linking arm when moving along with the deformation on the tissue surface that awaits measuring, the central zone that drives the support is to keeping away from the direction lifting on the tissue surface that awaits measuring. The utility model provides a wearable structure collects the tissue fluid to the regional printing opacity runner of support center through tissue fluid collection piece, can make the central zone of support form the space of abscission to keeping away from the direction lifting on the tissue surface that awaits measuring through the deformation on the tissue surface that awaits measuring, and this space of abscission can supply to detect light incidence, can analyze the composition of tissue fluid through detecting the optical signal through printing opacity runner outgoing, detects more fast, accurate.
Drawings
Fig. 1 is a plan view of a wearable structure for biological detection shown in a planar state according to a first embodiment;
fig. 2 is a side view of a wearable structure for bio-detection shown in accordance with a first embodiment, after lifting of the central area;
fig. 3 is a schematic view of the detection principle of the wearable structure for bio-detection according to the first embodiment;
FIG. 4 is a schematic cross-sectional view of the wearable structure for bioassay of FIG. 1 taken along line I-I;
fig. 5 is a side view of a wearable structure for bio-detection shown in accordance with a second embodiment after the central region is raised.
Detailed Description
The following description of the embodiments of the present application is provided for illustrative purposes, and other advantages and capabilities of the present application will become apparent to those skilled in the art from the present disclosure.
In the following description, reference is made to the accompanying drawings that describe several embodiments of the application. It is to be understood that other embodiments may be utilized and that mechanical, structural, electrical, and operational changes may be made without departing from the spirit and scope of the present application. The following detailed description is not to be taken in a limiting sense, and the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application.
Although the terms first, second, etc. may be used herein to describe various elements in some instances, these elements should not be limited by these terms. These terms are only used to distinguish one element from another.
Also, as used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context indicates otherwise. It will be further understood that the terms "comprises," "comprising," "includes" and/or "including," when used in this specification, specify the presence of stated features, steps, operations, elements, components, items, species, and/or groups, but do not preclude the presence, or addition of one or more other features, steps, operations, elements, components, species, and/or groups thereof. The terms "or" and/or "as used herein are to be construed as inclusive or meaning any one or any combination. Thus, "A, B or C" or "A, B and/or C" means "any of the following: a; b; c; a and B; a and C; b and C; A. b and C ". An exception to this definition will occur only when a combination of elements, functions, steps or operations are inherently mutually exclusive in some way.
The utility model provides a wearable structure for biological detection, gather the piece including support and tissue fluid, the support includes central zone and a plurality of linking arm, a plurality of linking arms set up along central zone's circumference interval, the first end and the central zone of linking arm are connected, the second end of linking arm can be directly or indirectly fixed at the tissue surface that awaits measuring, the central zone is equipped with the printing opacity runner, the printing opacity runner is gathered a intercommunication with tissue fluid, at least partial linking arm when moving along with the deformation on the tissue surface that awaits measuring, the central zone that drives the support is to keeping away from the direction lifting on the tissue surface that awaits measuring.
The tissue to be detected is human skin, for example, and the surface of the tissue to be detected can be deformed by bending limbs or squeezing the tissue to be detected by external force. The tissue fluid collecting piece is used for penetrating into a tissue to be detected, the light-transmitting flow channel is communicated with the tissue fluid collecting piece, and the tissue fluid collected by the tissue fluid collecting piece enters the light-transmitting flow channel in the central area of the support through siphon action to be collected. The support passes through the linking arm and directly or indirectly fixes at the tissue surface that awaits measuring, when needing to detect, can drive at least some linking arm motion through the deformation on the tissue surface that awaits measuring, the central zone that promotes the support is to keeping away from the direction lifting formation off-plane space on the tissue surface that awaits measuring, this off-plane space can supply to detect light incidence, detect light and incide this space through the clearance between the linking arm after the transmission of light passageway outgoing, in this process, composition among the transmission of light passageway absorbs or the effect light, can assay the composition of interstitial fluid through detecting the light signal of transmission of light passageway outgoing. Because the tissue fluid just breaks away from the tissue and just detects and the printing opacity runner of detection environment can play the effect of simulation tissue environment for the composition and the state of tissue fluid all are the same basically with in the tissue, not only detect more fast, and the testing result is also more accurate.
The wearable structure for bio-detection of the present application is described in detail by various embodiments below.
First embodiment
Fig. 1 is a plan view of a wearable structure for biological detection shown in a planar state according to a first embodiment. Fig. 2 is a side view of a wearable structure for bio-detection shown in accordance with a first embodiment, after lifting of the central area. As shown in fig. 1 and fig. 2, the wearable structure for biological detection of the present embodiment includes a support 1, a tissue fluid collecting member 2 and a flexible substrate 3.
The bracket 1 comprises a central area 11, a first connecting arm 121, a second connecting arm 122, a third connecting arm 123 and a fourth connecting arm 124, wherein the first connecting arm 121, the second connecting arm 122, the third connecting arm 123 and the fourth connecting arm 124 are arranged at intervals along the circumferential direction of the central area 11, the first ends of the first connecting arm 121, the second connecting arm 122, the third connecting arm 123 and the fourth connecting arm 124 are respectively connected with the central area 11, the second ends of the first connecting arm 121, the second connecting arm 122, the third connecting arm 123 and the fourth connecting arm 124 are respectively fixed on the first side of the flexible substrate 3, and partial areas or all areas of the second side of the flexible substrate 3 are used for being stuck to the surface of a tissue to be detected, so that the connecting arms are indirectly fixed on the surface of the tissue to be detected. When the first connecting arm 121, the second connecting arm 122, the third connecting arm 123 and the fourth connecting arm 124 move (as indicated by arrows in fig. 2) along with the deformation of the surface of the tissue to be measured, the central region 11 of the bracket 1 is pushed to lift away from the surface of the tissue to be measured and leave the flexible substrate 3, so as to form an out-of-plane space.
The first connecting arm 121, the second connecting arm 122, the third connecting arm 123 and the fourth connecting arm 124 are curved or linear, and the curved shapes include but are not limited to a semi-arc shape, a snake shape or a broken line shape, so that the whole support 1 presents a paper-cut structure, and the form change in space is better realized. The flexible substrate 3 can be prepared from organic memory polymer (tin-doped polyethylene glycol or polylactic acid material), metal alloy material (AZ 31 magnesium alloy, metal titanium and gold) and the like, and has certain structural deformation strength. In practical implementation, the flexible substrate 3 may not be provided, and the first connecting arm 121, the second connecting arm 122, the third connecting arm 123 and the fourth connecting arm 124 may be provided with adhesive structures at the second ends thereof, so as to be directly fixed on the surface of the tissue to be measured.
The central area 11 of the support 1 is provided with a light-transmitting flow channel 13, and the light-transmitting flow channel 13 can be manufactured by 3D printing of Polydimethylsiloxane (PDMS), polyethylene terephthalate (PET) or polymethyl methacrylate (PMMA), and has light-transmitting property and deformation capability. The light-transmitting flow passage 13 is communicated with the tissue fluid collecting piece 2, optionally, the tissue fluid collecting piece 2 is a micro-needle structure, and the micro-needle structure is fixed on the second side of the flexible substrate 3.
The first connecting arm 121, the second connecting arm 122, the third connecting arm 123 and the fourth connecting arm 124 include at least one connecting arm with an inlet channel and at least one connecting arm with an outlet channel. In this embodiment, the first connecting arm 121 is provided with a first inlet flow passage 125, the fourth connecting arm 124 is provided with a second inlet flow passage 128, the second connecting arm 122 is provided with a first outlet flow passage 126, and the third connecting arm 123 is provided with a second outlet flow passage 127. The first inlet channel 125 connects the first tissue fluid inlet 14 and the light transmission channel 13 of the stent 1, the second inlet channel 128 connects the second tissue fluid inlet 17 and the light transmission channel 13 of the stent 1, the first outlet channel 126 connects the first tissue fluid outlet 15 and the light transmission channel 13 of the stent 1, and the second outlet channel 127 connects the second tissue fluid outlet 16 and the light transmission channel 13 of the stent 1. The flexible substrate 3 is provided with through holes at the first tissue fluid inlet 14 and the second tissue fluid inlet 17, and the two tissue fluid collecting pieces 2 are respectively communicated with the first tissue fluid inlet 14 and the second tissue fluid inlet 17 through the corresponding through holes.
The light-transmitting flow channel 13 of the central area 11 of the stent 1 has a more complex pattern, so that the interstitial fluid capacity of the central area 11 can be increased and a sufficient detection area can be ensured, and the width of the light-transmitting flow channel 13 is 0.1-10 μm, so that the interstitial fluid can be ensured to sequentially pass through. In this embodiment, the light-transmitting flow channel 13 includes a plurality of annular flow channels 131 and a plurality of connecting flow channels 132, the plurality of annular flow channels 131 have different radii and are concentrically disposed, the connecting flow channels 132 communicate with adjacent annular flow channels 131, and the annular flow channel 131 located at the outermost layer communicates with the flow channels on the first connecting arm 121, the second connecting arm 122, the third connecting arm 123, and the fourth connecting arm 124, so as to achieve directional collection and flow of tissue fluid. When the support 1 is deformed in an out-of-plane way, the flow channel in the central area 11 and the flow channel on the connecting arm are not communicated due to the deformation of the support 1, so that the fluidity of the tissue fluid in the light-transmitting flow channel 13 can be reduced or even stopped, and the accuracy and the stability of a detection object can be improved.
As shown in fig. 3, after the central region 11 of the stent 1 is lifted in a direction away from the surface of the tissue to be measured, an out-of-plane space is formed between the central region 11 of the stent 1 and the flexible substrate 3, a detection light (indicated by an arrow in fig. 3) enters the space between the central region 11 of the stent 1 and the flexible substrate 3 through a gap between the connecting arms and exits through the light-transmitting flow channel 13, in the process, the components in the light-transmitting flow channel 13 absorb or act on the detection light, and the components of the interstitial fluid can be analyzed by receiving an optical signal exiting through the light-transmitting flow channel 13 by an instrument such as a photometer. Because the tissue fluid just breaks away from the tissue and detects just and the printing opacity runner 13 of detection environment can play the effect of simulation tissue environment for the composition and the state of tissue fluid all are the same basically with in the tissue, not only detect more fast, and the testing result is also more accurate.
Referring to fig. 4, in the present embodiment, the light-transmitting flow channel 13 is a closed flow channel, and the top wall 135 and the bottom wall 134 of the light-transmitting flow channel 13 transmit light, wherein the bottom wall 134 is a side of the light-transmitting flow channel 13 close to the flexible substrate 3, and the top wall 135 is a side of the light-transmitting flow channel 13 facing away from the flexible substrate 3.
Optionally, a modification material layer 136 is disposed on a surface of the sidewall 133 of at least a portion of the region of the light-transmitting channel 13, and the modification material layer 136 is used for enriching a specific component in the tissue fluid. For example, polar biological small molecules are enriched by electrodes, and biological large molecules such as exosomes are enriched by inorganic particles such as titanium oxide particles. Optionally, the modification material layer 136 is a carbon dioxide nanosphere layer, and the enrichment of exosomes is completed through specific linkage of phospholipid bilayers on the surface of exosomes and the exosome nanoparticles; and/or the modification material layer 136 is a surface modification cloth Lu Shilan and a metal electrode layer of glucose oxidase, the metal electrode layer is connected with an external electrode, and glucose can be enriched and decomposed into hydrogen peroxide for detection through the surface modification cloth Lu Shilan of the metal electrode layer and the glucose oxidase. In actual implementation, the transparent flow channel 13 in different regions may be modified with inorganic particles and metal electrode layers, or only the transparent flow channel 13 may be modified with inorganic particles or metal electrode layers. In practice, the modification material layer 136 may not be disposed in the light-transmitting channel 13, and the biological tissue fluid stock solution may be directly detected.
The bottom wall 134 may not be provided in the light-transmitting flow channel 13 according to the substance to be enriched in the modifying material layer 136. For example, the modification material layer 136 is a carbon dioxide nanosphere layer, and the exosome is enriched by the specific linkage between the phospholipid bilayer on the surface of the exosome and the nanoparticle of the exosome, and the exosome is attached to the side wall 133 of the light-transmitting flow channel 13 after being enriched, and the light-transmitting flow channel 13 is not provided with the bottom wall 134, and at this time, the tissue fluid is left on the flexible substrate 3. When the light-transmissive flow channel 13 is not provided with the bottom wall 134, the flexible substrate 3 needs to be kept in relatively close contact with the side wall 133 of the light-transmissive flow channel 13 in a planar state to ensure that tissue fluid can be collected toward the central region 11 of the stent 1.
When the wearable structure for biological detection of this embodiment is used, the flexible substrate 3 is attached to the surface of the tissue to be detected through the gum preset on the second side of the flexible substrate 3, and the tissue fluid collecting piece 2 is ensured to penetrate into the tissue to be detected. At this time, the surface of the tissue to be measured is kept not to deform, so that the stent 1 and the flexible substrate 3 are in a planar state, and the tissue fluid collected by the tissue fluid collecting member 2 enters the light-transmitting flow channel 13 in the central area 11 of the stent 1 for collection through siphon action.
When the modification material layer 136 in the light-transmitting flow channel 13 is a carbon dioxide nanosphere layer, the enrichment of exosomes in the light-transmitting flow channel 13 is completed after a period of time through the specific linkage of phospholipid bilayer on the surface of exosomes and the nanoparticle of the dioxides. After the enrichment process is completed, the central region 11 of the stent 1 is separated from the flexible substrate 3 by compressing the flexible substrate 3 to form an out-of-plane space, and the tissue fluid in the light-transmitting flow channel 13 stops flowing. Then, the amount of the enriched exosomes can be quantitatively calculated by performing photoexcitation detection in the out-of-plane space, irradiating the central region 11 with detection light to generate a detection light signal, and comparing the wavelengths of diffracted light emitted from the central region 11.
When the modifying material layer 136 is the surface modifying cloth Lu Shilan and the metal electrode layer of glucose oxidase, glucose can be enriched and glucose can be decomposed into hydrogen peroxide. After the enrichment process is completed, the central area 11 of the stent 1 is separated from the flexible substrate 3 to form an out-of-plane space by pressing the flexible substrate 3, and the interstitial fluid in the light-transmitting flow channel 13 also stops flowing. The light excitation detection is carried out through the out-of-plane space, the central area 11 is irradiated by the detection light to generate a detection light signal, the light signal light emitted from the central area 11 is collected by a photometer, and the blood sugar content in the light-transmitting flow channel 13 can be detected through the absorption spectrum of the detection signal light.
After the detection is finished, the flexible substrate 3 is unfolded, the support 1 is restored to the planar state, the light-transmitting flow channel 13 is restored to the circulating state, and pure water is injected to clean the light-transmitting flow channel 13 so as to continue the detection.
The utility model provides a wearable structure for biological detection, gather the piece including support and tissue fluid, the support includes central zone and a plurality of linking arm, a plurality of linking arms set up along central zone's circumference interval, the first end and the central zone of linking arm are connected, the second end of linking arm can be directly or indirectly fixed at the tissue surface that awaits measuring, the central zone is equipped with the printing opacity runner, the printing opacity runner is gathered a intercommunication with tissue fluid, at least partial linking arm when moving along with the deformation on the tissue surface that awaits measuring, the central zone that drives the support is to keeping away from the direction lifting on the tissue surface that awaits measuring. The utility model provides a wearable structure collects the tissue fluid to support central region's printing opacity runner through tissue fluid collection piece, deformation through the tissue surface that awaits measuring can make the central region of support to keeping away from the direction lifting formation off-plane space on the tissue surface that awaits measuring, this off-plane space can supply to detect light incidence, can analyze the composition of tissue fluid through the light signal that detects through printing opacity runner outgoing, this application can directly detect tissue fluid in wearable structure, need not to shift to high-precision instrument, it is faster, accurate to detect. In addition, the device structure is light and quick, and the enrichment method is various and has universality.
Second embodiment
Fig. 5 is a side view of a wearable structure for bio-detection shown according to a second embodiment. As shown in fig. 5, the wearable structure for biological detection of the present embodiment is mainly different from the first embodiment in that: and a cover 18, the top of the light-transmitting flow channel is open instead of the closed flow channel, the bottom wall of the light-transmitting flow channel is light-transmitting, the cover 18 includes at least one openable portion connected to at least a part of the connecting arms, respectively, fig. 5 only shows a first openable portion 181 connected to the third connecting arm 123 and a second openable portion 182 connected to the fourth connecting arm 124. In practical implementation, each connecting arm may be correspondingly connected to one openable and closable portion, or multiple connecting arms may be simultaneously connected to one openable and closable portion, and the number of the openable and closable portions may be one or multiple according to the opening and closing manner.
The openable part covers the light-transmitting flow channel 13 when being closed, and the top opening of the light-transmitting flow channel 13 can be covered at the moment so as to prevent tissue fluid from being polluted; the openable part is opened when the central area 11 of the support 1 is lifted, and at the moment, detection light enters an out-of-plane space between the central area 11 of the support 1 and the flexible substrate 3 and is emitted through the light-transmitting flow channel 13 and then can be collected by an instrument.
The runner in the bracket 1 can be cleaned more conveniently by designing the cover body 18 which can be opened and closed.
The above embodiments are merely illustrative of the principles and utilities of the present application and are not intended to limit the present application. Any person skilled in the art can modify or change the above-described embodiments without departing from the spirit and scope of the present application. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical concepts disclosed in the present application shall be covered by the claims of the present application.
Claims (10)
1. The utility model provides a wearable structure for biological detection, its characterized in that includes that support and tissue fluid gather the piece, the support includes central zone and a plurality of linking arm, and is a plurality of the linking arm is followed central zone's circumference interval sets up, the first end of linking arm with central zone connects, the second end of linking arm can directly or indirectly fix at the tissue surface that awaits measuring, central zone is equipped with the printing opacity runner, the printing opacity runner with tissue fluid gathers a intercommunication, tissue fluid gathers the piece and is arranged in piercing the tissue that awaits measuring, tissue fluid that tissue fluid gathered gets into through the siphon effect the printing opacity runner is collected, at least part the linking arm is along with during the deformation of tissue surface that awaits measuring moves, drive the support central zone is to keeping away from the orientation lifting of tissue surface that awaits measuring forms the out-of-plane space, the out-of-plane space can supply to detect light incidence, detect light through clearance between the linking arm is incited after the out-of-plane space is inside, the warp the printing opacity runner outgoing.
2. The wearable structure for biological detection according to claim 1, wherein the plurality of connecting arms comprises at least one connecting arm having an inlet channel and at least one connecting arm having an outlet channel, two ends of the inlet channel are respectively communicated with the channel inlet of the transparent channel and the tissue fluid collecting member, and two ends of the outlet channel are respectively communicated with the channel outlet of the transparent channel and the tissue fluid outlet of the support.
3. The wearable structure for biological detection according to claim 1 or 2, further comprising a flexible substrate, wherein the second end of the connecting arm is fixed on a first side of the flexible substrate, and a partial area or a whole area of the second side of the flexible substrate is used for adhering to the surface of the tissue to be detected.
4. The wearable structure for biological detection of claim 3, wherein the interstitial fluid collection member is a microneedle structure secured to the second side of the flexible substrate; and/or the connecting arm is curved or linear.
5. The wearable structure for biological detection of claim 1, wherein the light transmissive flow channel comprises a plurality of annular flow channels and a plurality of connecting flow channels, the annular flow channels are arranged concentrically and have different radii, and the connecting flow channels communicate with adjacent annular flow channels.
6. The wearable structure for biological detection according to claim 1 or 5, wherein the side wall surface of at least a part of the area of the light-transmitting flow channel is provided with a layer of modification material, and the layer of modification material is used for enriching specific components in tissue fluid.
7. The wearable structure for biological detection of claim 6, wherein the layer of the modification material is a layer of carbon dioxide nanospheres; and/or the modification material layer is a metal electrode layer of surface modification cloth Lu Shilan and glucose oxidase, and the metal electrode layer is connected with an external electrode.
8. The wearable structure for biological detection of claim 6, wherein the width of the light-transmissive flow channel is 0.1-10 μm.
9. The wearable structure for biological detection of claim 1, wherein the light-transmissive flow channel is a closed flow channel, and wherein top and bottom walls of the light-transmissive flow channel are light-transmissive.
10. The wearable structure for biological detection according to claim 1, further comprising a cover, wherein the top of the light-transmissive flow channel is open, and the bottom wall of the light-transmissive flow channel is light-transmissive, wherein the cover comprises at least one openable portion connected to at least a portion of the connecting arm, wherein the openable portion covers the light-transmissive flow channel when closed, and wherein the openable portion is opened when the central region of the support is raised.
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