CN112494796A - Pat cosmetic paster of formula micropin - Google Patents
Pat cosmetic paster of formula micropin Download PDFInfo
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- CN112494796A CN112494796A CN202011391049.6A CN202011391049A CN112494796A CN 112494796 A CN112494796 A CN 112494796A CN 202011391049 A CN202011391049 A CN 202011391049A CN 112494796 A CN112494796 A CN 112494796A
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- elastic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
Abstract
The invention provides a flapping type microneedle cosmetic patch, which comprises a diffusible cosmetic substance, an elastic medicine carrying device, a microneedle array and a connecting part, wherein the connecting part is used for fixing the elastic medicine carrying device on the surface of human skin; the diffusible cosmetic substance is loaded in the elastic medicine-loading device; the microneedle array is arranged in the elastic medicine carrying device and positioned at the top of the elastic medicine carrying device, and the needle head of the microneedle array faces the bottom of the elastic medicine carrying device; when using, press and pat the top of elasticity medicine carrier, the microneedle array pass elasticity medicine carrier pierce human skin, cause the microchannel, elasticity medicine carrier recover initial shape and elasticity that produces make microneedle array pull out from human skin, but diffusible cosmetic material carry out the skin channel with the form of diffusion through the microchannel and carry. The invention can improve the absorption efficiency of the beauty treatment substances and simultaneously has the characteristics of minimal invasion, no pain and portability.
Description
Technical Field
The invention relates to the technical field of beauty equipment, in particular to a flapping type micro-needle beauty patch.
Background
With the development of beauty medicine, more and more cosmetic substances are used in beauty fields, such as collagen, hyaluronic acid, vitamin C and its derivatives, niacinamide, lecithin, peptides, etc. At present, the main use mode of the components of the cosmetic substances is absorption and utilization through a percutaneous transportation mode, namely the components are made into gel or facial mask and then coated on the surface of skin to achieve the cosmetic effect. However, the skin is a natural barrier of human body, and has good absorption effect only for lipophilic substances with molecular weight less than 500 daltons, and some macromolecular cosmetic substances such as collagen, peptide and the like are difficult to permeate the barrier in sufficient quantity. Secondly, the molecular weight, polarity, melting point and the like of the beauty components can influence the percutaneous absorption degree of the beauty components; in addition, microorganisms on the skin surface and enzymes in the skin can degrade some cosmetic ingredients.
The barrier action of the skin can be solved by modern penetration-promoting techniques, which are divided into two major categories, chemical penetration-promoting and physical penetration-promoting. The chemical method mainly depends on a chemical transdermal penetration enhancer, and the main action mechanism is to improve the fluidity of lipid by interfering the lipid bilayer structure of stratum corneum, and finally change the dispersion coefficient of a diffusion substance to achieve the purpose of increasing the penetration amount. The physical method is to improve the permeation of the skin to the diffusion substances by physical means, such as ultrasonic permeation promotion, ion introduction permeation promotion, micro-needle permeation promotion, injection and the like. The existing micro-needle promotes the infiltration, such as Chinese patent publication numbers: CN 105581975 a, published: 2016.05.18, discloses microneedles and microneedle patches, wherein the microneedles comprise: a biocompatible matrix in the shape of microneedles and a plurality of porous particles. The plurality of porous particles are formed on a surface of the biocompatible matrix or at least a portion of an interior of the biocompatible matrix. However, the microneedles are easily contaminated after long-term exposure to air. Chemical agents used in chemical penetration enhancement may affect the activity of cosmetic ingredients; the ultrasonic penetration promotion relates to some complex external devices, and the problems of skin heating and the like can be caused after long-term use; iontophoresis promotes permeation involving weak currents that may damage the structure of some cosmetic substances, thereby affecting the cosmetic effect; jet injection is the breakdown of the stratum corneum by high pressure, high velocity fluids, which can cause pain and reduce human compliance with the procedure.
Disclosure of Invention
The invention provides a flapping type microneedle cosmetic patch for overcoming the problem of low cosmetic substance absorption efficiency in the prior art, which can improve the cosmetic substance absorption efficiency and has the characteristics of being minimally invasive, painless and portable.
In order to solve the technical problems, the technical scheme of the invention is as follows: a flapping type micro-needle beauty patch comprises a diffusible beauty substance, an elastic medicine carrying device, a micro-needle array and a connecting part for fixing the elastic medicine carrying device on the surface of human skin;
the diffusible cosmetic substance is loaded in the elastic medicine-loading device;
the microneedle array is arranged in the elastic medicine carrying device and positioned at the top of the elastic medicine carrying device, and the needle head of the microneedle array faces the bottom of the elastic medicine carrying device;
when using, press and pat the top of elasticity medicine carrier, the microneedle array pass elasticity medicine carrier pierce human skin, cause the microchannel, elasticity medicine carrier recover initial shape and elasticity that produces make microneedle array pull out from human skin, but diffusible cosmetic material carry out the skin channel with the form of diffusion through the microchannel and carry.
Preferably, the cosmetic patch further comprises an isolation film, and the isolation film is detachably connected to the bottom of the elastic medicine-carrying device; when in use, the isolating membrane needs to be detached.
Further, the elastic medicine carrying device comprises an elastic anti-seepage gasket and an elastic medicine carrying layer; the anti-seepage gasket is provided with a hollow groove structure; the top of the hollow groove structure is provided with a connecting layer connected with the microneedle array; the microneedle array is embedded in the elastic drug-loaded layer; the diffusible cosmetic substance is filled in the elastic medicine-carrying layer; the isolating membrane is detachably connected with the anti-seepage gasket and the elastic medicine-carrying layer.
Still further, the microneedle array comprises a microneedle array substrate and a plurality of microneedles arranged on the lower surface of the microneedle array substrate; the upper surface of the microneedle array substrate is connected with the connecting layer; the micro-needle is embedded in the elastic drug-loaded layer.
Still further, the elastic drug-loaded layer adopts porous hydrogel.
Still further, the porous hydrogel comprises one of polyacrylamide and chitosan interpenetrating polymer network hydrogel.
Still further, the connecting component can adopt a pressure-sensitive adhesive layer, namely the pressure-sensitive adhesive layer is arranged at the bottom of the anti-seepage gasket; the isolating film is covered on the pressure-sensitive adhesive layer.
Furthermore, the connecting layer adopts a medical adhesive tape; the microneedle array is fixed on the top of the anti-seepage gasket through a medical adhesive tape.
Still further, the diffusible cosmetic substance includes, but is not limited to, collagen, liposomes, nanoparticles.
Still further, the cosmetic patch also comprises a metal electrode plate; the metal electrode plate is arranged between the microneedle array and the connecting layer; the metal electrode slice is used for an external power supply.
Compared with the prior art, the technical scheme of the invention has the beneficial effects that:
the invention realizes that the micro-needle array forms the micro-channel on the human skin by flapping, improves the diffusible cosmetic substance diffusion capacity, thereby realizing the improvement of the absorption efficiency of the human skin for absorbing the cosmetic substance.
Drawings
Fig. 1 is a schematic structural view of a patting-type microneedle cosmetic patch according to example 1.
Fig. 2 is a schematic view of the patting-type microneedle cosmetic patch according to example 1 adhered to the skin surface.
Fig. 3 is a schematic view of the process of puncturing human skin by the patting type microneedle cosmetic patch according to embodiment 1.
Fig. 4 is a schematic view showing the spreading of the diffusible cosmetic substance after the patting-type microneedle cosmetic patch described in example 1 releases the pressing force.
Fig. 5 is a schematic view of the flapwise microneedle cosmetic patch of example 2 showing the diffusible cosmetic substance diffused after being powered on.
In the figure, 1-diffusible beauty substance, 2-elastic medicine-carrying layer, 3-isolation film, 4-pressure sensitive adhesive layer, 5-micro needle array, 6-medical adhesive tape, 7-anti-seepage gasket, 8-human skin, 9-metal electrode slice and 10-metal electrode.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and are used for illustration only, and should not be construed as limiting the patent. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The technical solution of the present invention is further described below with reference to the accompanying drawings and examples.
Example 1
As shown in fig. 1, a patting type microneedle cosmetic patch comprises a diffusible cosmetic substance 1, an elastic drug-carrying device, a microneedle array 5, and a connecting part for fixing the elastic drug-carrying device on the surface of human skin 8;
the diffusible cosmetic substance 1 is loaded in the elastic medicine-loading device;
the microneedle array 1 is arranged inside the elastic medicine carrying device and positioned at the top of the elastic medicine carrying device, and the needle head of the microneedle array 1 faces the bottom of the elastic medicine carrying device;
when using, press and pat the top of elasticity medicine carrier, microneedle array 1 pass elasticity medicine carrier pierce human skin 8, form the microchannel, elasticity that elasticity medicine carrier resume initial shape and produce make microneedle array 5 pull out from human skin 8, but diffusible cosmetic material 1 carry out the skin through the microchannel with the form of diffusion and carry.
In a specific embodiment, the cosmetic patch further comprises an isolating membrane 3, wherein the isolating membrane 3 is detachably connected to the bottom of the elastic medicine-carrying device; in use, the isolation diaphragm 3 needs to be detached. When not in use, the barrier film 3 may seal the diffusible cosmetic substance 1 in the elastic drug-loaded device to prevent leakage.
In a specific embodiment, the elastic medicine carrying device comprises an elastic anti-seepage gasket 7, an elastic medicine carrying layer 2; the anti-seepage gasket 7 is provided with a hollow groove structure; the top of the hollow groove structure is provided with a connecting layer connected with the microneedle array 1; the microneedle array 5 is embedded in the elastic drug-loaded layer 2; the diffusible cosmetic substance 1 is filled in the elastic drug-loaded layer 2; the isolating membrane 4 is detachably connected with the anti-seepage gasket 7 and the elastic medicine-carrying layer 2.
The elastic drug-loaded layer 2 needs to have good biocompatibility, elasticity and a porous structure. The elastic drug-loaded layer 2 is attached to the skin, so that a biocompatible material should be selected to avoid inflammation, and the material must be soft to avoid discomfort or injury to the skin. The material should have a porous structure in order to ensure a good loading capacity of the diffusible cosmetic substance 1. The elastic medicine carrying layer 2 has good cosmetic material carrying capacity, and is preferably made of porous material. After the external swatting is finished, the microneedle array 5 needs to be pulled out of the skin by the elasticity of the elastic drug-loaded layer 2 to transport the diffusible cosmetic substance 1 by using a microchannel, and therefore, an elastic material is preferable. In the embodiment, materials with conductive performance can be selected to prepare the elastic drug-loaded layer, and the permeation promotion of the microneedle array 5 and the iontophoresis permeation promotion can be combined, so that the permeation promotion effect is further improved. According to the above requirements, the material of the elastic drug-loaded layer 2 should have biocompatibility, conductivity, elasticity, and porous structure, so that porous hydrogel can be adopted, and the specific material of the porous hydrogel is one of polyacrylamide, chitosan interpenetrating polymer network hydrogel, and the like.
In this embodiment, the volume of the elastic drug-loaded layer 2 loaded with the diffusible cosmetic substance 1 is about 150 μ L, and the diffusible cosmetic substance 1 is uniformly distributed in the elastic drug-loaded layer 2 and released from the porous structure of the elastic drug-loaded layer 2.
The microneedle array 5 and the elastic drug-loaded layer 2 are both positioned inside the anti-seepage gasket 7, and the anti-seepage gasket 7 can prevent the components of the diffusible cosmetic substance 1 in the elastic drug-loaded layer 2 from seeping out.
In a specific embodiment, the microneedle array 5 comprises a microneedle array substrate, a plurality of microneedles arranged on the lower surface of the microneedle array substrate; the upper surface of the microneedle array substrate is connected with the connecting layer; the micro-needle is embedded in the elastic drug-loaded layer.
The microneedle array 5 of this embodiment is made of stainless steel or the like. When the micro-needle array is used, the micro-needle penetrates into the human skin 8 to form a drug delivery micro-channel, so that the diffusible cosmetic substance 1 can be diffused and released, and meanwhile, the micro-needle array 5 also needs to have certain mechanical strength.
This example uses the elastic drug-loaded layer 2 as a controlled release sandwich for the diffusible cosmetic substance 1, where the elastic drug-loaded layer 2 can be used to store different types of diffusible cosmetic substances 1. In addition, the elastic drug-loaded layer 2 can also protect the microneedle array 5, prevent the microneedles from being broken and avoid bacteria from infecting the skin through the microchannels. The elastic medicine-carrying layer 2 can continuously and slowly release the diffusible cosmetic substance 1 in a percutaneous mode, and the effective slow release time and speed of the elastic medicine-carrying layer are mainly controlled by changing the content of the diffusible cosmetic substance 1 in the elastic medicine-carrying layer 2 and the like.
The impermeable gasket 7 is to prevent the diffusion of the diffusible cosmetic substance 1 from the elastic drug-loaded layer 2 and to prevent the entry of external bacteria into the closed environment, which may cause inflammatory reaction of the skin. The impervious gasket 7 also needs to absorb liquid generated in the using process, so the impervious gasket 7 is made of soft material with certain water absorption performance, and the impervious gasket 7 can be made of medical absorbent pads.
In a specific embodiment, the connecting component can adopt a pressure-sensitive adhesive layer 4, namely, the pressure-sensitive adhesive layer 4 is arranged at the bottom of the impermeable gasket 7; the isolating film 3 is covered on the pressure-sensitive adhesive layer 4. The pressure-sensitive adhesive layer 4 of this embodiment has a sticky property, and can adhere the anti-seepage gasket 7 to the surface 8 of the human body, so as to fix the beauty patch on the surface of the skin 8 of the human body.
In a specific embodiment, the connecting layer adopts medical adhesive tape 6; the microneedle array 5 is fixed on the top of the impervious gasket 7 through the medical adhesive tape 6. The medical adhesive tape 6 has the characteristics of flexibility, antibacterial property and water resistance.
In a specific embodiment, the diffusible cosmetic material 1 may be a macromolecular cosmetic material including, but not limited to, collagen, liposomes, nanoparticles. And the diffusible substance is uniformly distributed in the elastic drug-loaded layer.
The cosmetic patch of the embodiment is prepared by the following method:
(1) the micro-needle array 5 is prepared by a micro-electronic mechanical processing technology, the prepared micro-needle array 5 can be further improved so as to improve the biocompatibility, the conductivity and the mechanical strength of the micro-needle array 5, and the micro-needle array 5 is disinfected by alcohol before use;
(2) mixing the elastic medicine-carrying layer without the diffusible cosmetic substance 1 with the diffusible cosmetic substance 1 solution, and filling the diffusible cosmetic substance 1 into the elastic medicine-carrying layer 2 through swelling, adsorption and other ways;
(3) processing a hollow groove structure penetrating through the impervious gasket 7 on the impervious gasket 7, and placing the elastic drug-loaded layer 2 and the microneedle array 5;
(4) coating the pressure-sensitive adhesive layer 4 on the lower surface of the anti-seepage gasket 7, and covering the surface of the anti-seepage gasket with the isolating film 3;
(5) firstly, the elastic drug-loaded layer 2 prepared in the step (2) is placed in the hollow groove structure of the anti-seepage gasket 7 prepared in the step (3), then the microneedle array 5 prepared in the step (1) is placed in the hollow groove structure, microneedles penetrate into the elastic drug-loaded layer, and finally the medical adhesive tape 6 is adhered to the upper surface of the anti-seepage gasket.
When the anti-seepage mask is used, the isolating film 3 on the upper surface of the pressure-sensitive adhesive layer 4 is peeled off, the lower surface of the anti-seepage gasket 7 is tightly combined with the surface of human skin 8 under the action of the pressure-sensitive adhesive layer 4, and the efficiency of percutaneous absorption of diffusible cosmetic substances can be effectively improved after the beating action.
Example 2
In addition to the cosmetic patch described in example 1, an iontophoresis penetration-promoting method may be combined in order to further improve the absorption efficiency of the diffusible cosmetic substance. In combination with the iontophoresis penetration-promoting method, the design of the cosmetic patch needs to be appropriately adjusted. As shown in fig. 5, the cosmetic patch further includes a metal electrode sheet 9; the metal electrode plate 9 is arranged between the microneedle array 5 and the connecting layer; the metal electrode plate 9 is used for an external power supply.
In this embodiment, a second hollow groove penetrating through the self-defense gasket is formed in the self-defense gasket and used for placing the metal electrode 10, one end of the metal electrode 10 is used for contacting with the skin of a human body, and the other end of the metal electrode is used for being connected with a power supply. After an external current source is connected, a closed current path is formed through the skin among the conductive metal electrode plate 9, the microneedle array 5, the elastic drug-loaded layer 2 and the metal electrode 9, so that the iontophoresis permeation promotion is realized.
When iontophoresis and electroosmosis are performed using the metal electrode sheet 9, the diffusible cosmetic substance 1 further increases the transport rate under the action of electromigration and electroosmosis. The outer surface of the cosmetic patch can be periodically flapped during use to prevent self-healing of the microchannel. Meanwhile, the transportation rate of the diffusible cosmetic substance 1 can be autonomously controlled by closing and increasing the current, and certain controlled release is realized. Therefore, the beauty patch of the embodiment integrates three processes of coating, skin puncture and transmission and realizes portability of diffusible beauty substance transportation by adding the elastic medicine-carrying layer 2 and the metal electrode plate 9 and utilizing the characteristics of the elastic medicine-carrying layer 2 and the position relation of the elastic medicine-carrying layer and the micropore array 5.
It should be understood that the above-described embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.
Claims (10)
1. A cosmetic paster of formula of patting micropin which characterized in that: comprises a diffusible cosmetic substance, an elastic medicine-carrying device, a micro-needle array and a connecting part for fixing the elastic medicine-carrying device on the surface of human skin;
the diffusible cosmetic substance is loaded in the elastic medicine-loading device;
the microneedle array is arranged in the elastic medicine carrying device and positioned at the top of the elastic medicine carrying device, and the needle head of the microneedle array faces the bottom of the elastic medicine carrying device;
when using, press and pat the top of elasticity medicine carrier, the microneedle array pass elasticity medicine carrier pierce human skin, cause the microchannel, elasticity medicine carrier recover initial shape and elasticity that produces make microneedle array pull out from human skin, but diffusible cosmetic material carry out the skin channel with the form of diffusion through the microchannel and carry.
2. The patting-type microneedle cosmetic patch according to claim 1, wherein: the beauty patch also comprises an isolation film, and the isolation film is detachably connected to the bottom of the elastic medicine-carrying device; when in use, the isolating membrane needs to be detached.
3. The patting-type microneedle cosmetic patch according to claim 2, wherein: the elastic medicine carrying device comprises an elastic anti-seepage gasket and an elastic medicine carrying layer; the anti-seepage gasket is provided with a hollow groove structure; the top of the hollow groove structure is provided with a connecting layer connected with the microneedle array; the microneedle array is embedded in the elastic drug-loaded layer; the diffusible cosmetic substance is filled in the elastic medicine-carrying layer; the isolating membrane is detachably connected with the anti-seepage gasket and the elastic medicine-carrying layer.
4. The patting-type microneedle cosmetic patch according to claim 3, wherein: the micro-needle array comprises a micro-needle array substrate and a plurality of micro-needles arranged on the lower surface of the micro-needle array substrate; the upper surface of the microneedle array substrate is connected with the connecting layer; the micro-needle is embedded in the elastic drug-loaded layer.
5. The patting-type microneedle cosmetic patch according to claim 4, wherein: the elastic drug-loaded layer adopts porous hydrogel.
6. The patting-type microneedle cosmetic patch according to claim 5, wherein: the porous hydrogel comprises one of polyacrylamide and chitosan interpenetrating polymer network hydrogel.
7. The patting-type microneedle cosmetic patch according to claim 6, wherein: the connecting component can adopt a pressure-sensitive adhesive layer, namely the pressure-sensitive adhesive layer is arranged at the bottom of the anti-seepage gasket; the isolating film is covered on the pressure-sensitive adhesive layer.
8. The patting-type microneedle cosmetic patch as claimed in claim 7, wherein: the connecting layer adopts a medical adhesive tape; the microneedle array is fixed on the top of the anti-seepage gasket through a medical adhesive tape.
9. The patting-type microneedle cosmetic patch according to claim 8, wherein: the diffusible cosmetic material includes, but is not limited to, collagen, liposomes, nanoparticles.
10. The patting-type microneedle cosmetic patch according to claim 9, wherein: the beauty patch also comprises a metal electrode plate; the metal electrode plate is arranged between the microneedle array and the connecting layer; the metal electrode slice is used for an external power supply.
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| CN202011391049.6A CN112494796A (en) | 2020-12-02 | 2020-12-02 | Pat cosmetic paster of formula micropin |
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| CN202011391049.6A CN112494796A (en) | 2020-12-02 | 2020-12-02 | Pat cosmetic paster of formula micropin |
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| CN115120863A (en) * | 2022-07-07 | 2022-09-30 | 四川大学 | Microneedle patch and method for producing same |
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|---|---|---|---|---|
| CN113648530A (en) * | 2021-09-02 | 2021-11-16 | 中山大学 | Push type microneedle patch with double drug storage layers |
| CN115120863A (en) * | 2022-07-07 | 2022-09-30 | 四川大学 | Microneedle patch and method for producing same |
| CN115120863B (en) * | 2022-07-07 | 2023-06-13 | 四川大学 | Microneedle patch and preparation method thereof |
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Application publication date: 20210316 |