CN112473435A - Volatile oil spraying, stirring and clathrating device - Google Patents
Volatile oil spraying, stirring and clathrating device Download PDFInfo
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- CN112473435A CN112473435A CN202011510591.9A CN202011510591A CN112473435A CN 112473435 A CN112473435 A CN 112473435A CN 202011510591 A CN202011510591 A CN 202011510591A CN 112473435 A CN112473435 A CN 112473435A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/85—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with two or more stirrers on separate shafts
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/23—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis
- B01F27/232—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis with two or more rotation axes
- B01F27/2322—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis with two or more rotation axes with parallel axes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/90—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with paddles or arms
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/92—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with helices or screws
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/712—Feed mechanisms for feeding fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
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- Mixers Of The Rotary Stirring Type (AREA)
Abstract
The invention belongs to the field of medicine and food equipment, and particularly relates to a volatile oil spraying, stirring and clathrating device. Mainly constitute by control by temperature change formula agitator tank (1), high-efficient atomizer (2) and pressure-bearing formula liquid material jar (3), the jar body top of control by temperature change formula agitator tank (1) is provided with high-efficient atomizer (2), and pressure-bearing formula liquid material jar (3) keep UNICOM through liquid material pipe (8) and high-efficient atomizer (2). The invention has the advantages of ingenious design, reasonable structure and convenient operation, is suitable for stirring and clathrating the cyclodextrin of the volatile oil, continuously conveys the volatile oil solution to the high-efficiency atomizing spray head (2) from the pressure-bearing liquid tank (3) by means of compressed air, and sprays the volatile oil solution to the water-cyclodextrin mixed liquid in the temperature-controlled stirring tank (1) in a mist-shaped high-efficiency dispersion manner by the high-efficiency atomizing spray head, thereby realizing the high-efficiency dispersion, mixing and clathrating operations of the volatile oil and improving the clathration rate and yield of the volatile oil.
Description
Technical Field
The invention relates to a volatile oil spraying, stirring and clathrating device, which is suitable for stirring and clathrating cyclodextrin of volatile oil, and belongs to the field of medicine and food equipment.
Background
The volatile oil is also called essential oil, is a general name of a volatile oily component which can be obtained by steam distillation and is immiscible with water, mainly comprises terpenoids, aromatic compounds and oxygen-containing derivatives thereof such as alcohol, aldehyde, ketone, phenol, ether, lactone and the like, and has the effects of resisting inflammation, allergy, microorganism, mutation and cancer, expelling parasites, inhibiting enzymes, having the effect on the central nervous system and having the effect on the respiratory system. During the production process of the preparation of Chinese medicinal granules, pills, capsules, oral liquid and other dosage forms, a proper amount of volatile oil components obtained by extraction and separation are often added according to the medicament composition and preparation process characteristics of a preparation prescription so as to better exert the clinical curative effect.
In view of the volatile oil easily volatilizing and losing at normal temperature, the traditional Chinese medicine preparation is generally prepared into cyclodextrin inclusion compound in advance in the production process, and the cyclodextrin inclusion compound is prepared and formed in a preparation mode, so that the defect that the volatile oil is easily volatilized is overcome. The conventional volatile oil inclusion compound is mostly stirred and included by adopting a saturated aqueous solution method, but in the inclusion operation of the saturated aqueous solution method, the volatile oil is added in a direct dropwise adding mode, namely, a separating funnel or other containers filled with volatile oil solution are added dropwise and mixed at the same time. The direct dripping mode generates large volume of volatile oil liquid drops, the volatile oil is difficult to be dispersed in time and efficiently when the volatile oil is dripped into the water-cyclodextrin mixed liquid, and the ingredient segregation phenomenon exists, thereby influencing the inclusion rate of the inclusion compound. Meanwhile, in order to ensure the inclusion effect, the dripping speed of the volatile oil needs to be strictly controlled, the dripping speed is too fast to be beneficial to mixing and dispersing liquid drops, and the time is too slow to be consumed. Therefore, in the preparation of the volatile oil inclusion compound by a saturated aqueous solution method, the adding mode of the volatile oil needs to be improved and improved urgently, the adding time can be shortened, and the efficient dispersion and stirring inclusion of volatile oil droplets are facilitated.
Disclosure of Invention
Aiming at the common technical problems of low inclusion rate, low yield, long time consumption and the like in the process of preparing a volatile oil inclusion compound by the existing saturated aqueous solution method, the invention aims to provide a volatile oil spraying, stirring and inclusion device.
The inventor carries out optimization upgrading on a conveying and adding device of volatile oil on the basis of a volatile oil saturated aqueous solution inclusion method, continuously and hermetically conveys the volatile oil solution to a high-efficiency atomizing spray head from a pressure-bearing type liquid tank by means of compressed air, and sprays the volatile oil solution to a water-cyclodextrin mixed material liquid of a temperature control type stirring tank in a spraying manner in an efficient dispersion manner by the high-efficiency atomizing spray head, so that efficient dispersion, mixing and inclusion operations of the volatile oil are realized, the inclusion rate and the yield of the volatile oil are improved, and the inclusion effect is optimized.
The technical problem solved by the invention is realized by the following technical scheme:
the utility model provides a volatile oil spraying stirring inclusion device, mainly comprises control by temperature change formula agitator tank 1, high-efficient atomizer 2 and pressure-bearing formula liquid material jar 3, its characterized in that, the jar body top of control by temperature change formula agitator tank 1 is provided with high-efficient atomizer 2, and pressure-bearing formula liquid material jar 3 keeps the UNICOM through feed liquor pipe 7 of liquid material pipe 8 with high-efficient atomizer 2.
The upper part of the high-efficiency atomizing spray head 2 is provided with an air pressure guide pipe 4, and the air pressure guide pipe 4 is provided with a first air pressure regulating valve 5. Meanwhile, the electromagnetic flow regulating valve 6 is arranged in the middle of the high-efficiency atomizing spray head 2, and the atomizing frequency, the atomizing time and the atomizing degree of the high-efficiency atomizing spray head 2 can be regulated and controlled through the electromagnetic flow regulating valve 6.
The spout of the high-efficiency atomizing nozzle 2 is provided with an open liquid baffle 9.
In the invention, the top of the tank body of the temperature control type stirring tank 1 is provided with a main stirrer 10, and the right side of the temperature control type stirring tank is provided with a spiral auxiliary stirrer 11. The main stirrer 10 and the helical auxiliary stirrer 11 are controlled by a variable frequency speed regulator 12, and the stirring speed and the rotation direction can be adjusted and controlled.
The main stirrer 10 and the spiral auxiliary stirrer 11 rotate in opposite directions, the rotating speed of the main stirrer 10 is 50-70r/min, and the rotating speed of the spiral auxiliary stirrer 11 is 250-350 r/min.
Preferably, the rotation speed of the main stirrer 10 is 55r/min and the rotation speed of the helical sub-stirrer 11 is 325 r/min.
In the invention, the upper part of the pressure-bearing type liquid tank 3 is provided with a second air pressure regulating valve 13 and a pressure gauge 14, and the bottom of the pressure-bearing type liquid tank 3 is provided with a manual switch valve 15.
In the process of improving and upgrading the volatile oil spraying and stirring inclusion device, the inventor notices that in the inclusion operation of the inclusion aqueous solution, the volatile oil added into the water-cyclodextrin mixed liquid material has larger droplets by adopting a conventional volatile oil dripping mode, cannot be timely and efficiently dispersed in the subsequent stirring inclusion, has the component segregation phenomenon and influences the inclusion rate of the inclusion compound. Meanwhile, in order to ensure the inclusion effect, the dripping speed of the volatile oil needs to be strictly controlled, the dripping speed is too fast to be beneficial to mixing and dispersing liquid drops, and the time is too slow to be consumed. Therefore, the adding mode of the volatile oil is changed from a dripping mode to a spraying mode, the atomized liquid drops of the volatile oil generated by the high-efficiency atomizing nozzle 2 are efficiently dispersed, and then the atomized liquid drops are sprayed into the tank body of the temperature-controlled stirring tank 1 and are uniformly mixed with the water-cyclodextrin mixed liquid, so that the efficient dispersion, uniform mixing and efficient inclusion operation of the volatile oil are realized.
Specifically, when the volatile oil spraying and stirring inclusion device performs volatile oil inclusion operation, the manual switch valve 15 at the bottom of the pressure-bearing liquid material tank 3 is kept in a closed state, the second air pressure regulating valve 13 is closed, and the volatile oil or the volatile oil ethanol solution is added into the pressure-bearing liquid material tank 3. And (3) opening a second air pressure regulating valve 13, pressurizing the pressure-bearing type liquid tank 3 to a specified pressure range, opening a manual switch valve 15, and enabling the volatile oil to enter the efficient atomizing nozzle 2 along the liquid pipe 8 and the liquid inlet pipe 7 under the pushing of pressure difference. At the moment, the first air pressure regulating valve 5 is opened to carry out secondary pressurization on the volatile oil entering the high-efficiency atomizing nozzle 2, and meanwhile, the electromagnetic flow regulating valve 6 in the middle of the high-efficiency atomizing nozzle 2 is opened to control the spraying frequency and the spraying time of the high-efficiency atomizing nozzle 2.
The high-efficiency atomizing spray head 2 uniformly sprays the volatile oil or the volatile oil ethanol solution to the tank body of the temperature-controlled stirring tank 1 in a highly dispersed atomizing state, and the volatile oil or the volatile oil ethanol solution is efficiently stirred with the water-cyclodextrin mixed material liquid. During stirring, the stirring blades on the main stirrer 10 are large and rotate at a low speed, and are stirred in a forward rotation manner, and the generated stirring force is upward; the helical auxiliary agitator 11 has a small helical cross section and a large rotation speed, and performs reverse agitation with the generated agitation force directed downward. The main stirrer 10 and the spiral auxiliary stirrer 11 are matched with each other in a vertical and vertical mixing manner, so that the vertical flow of the liquid medicine is increased, the mixing process becomes a three-dimensional mixing process, the mixing is more sufficient and uniform, an ideal mixing effect is achieved, and the efficient dispersion, mixing and inclusion operation of the volatile oil is realized.
The invention has novel structure and convenient operation, can realize automatic control operation, is suitable for cyclodextrin stirring inclusion of volatile oil in workshops, and volatile oil solution is continuously and hermetically conveyed to the high-efficiency atomizing spray head by compressed air from the pressure-bearing liquid material tank and is sprayed into 'water-cyclodextrin' mixed material liquid in the tank body of the temperature control type stirring tank 1 in a mist-shaped high-efficiency dispersion manner by the high-efficiency atomizing spray head, so that the high-efficiency dispersion, mixing and inclusion operation of the volatile oil are realized, and the inclusion rate of the volatile oil is improved.
The invention has scientific design and obvious generated technical effect, and compared with the prior conventional volatile oil inclusion device, the invention has the following substantive characteristics and progresses:
1. the high-efficiency volatile oil spraying device organically combines the high-efficiency atomizing spray head device, the temperature-controlled stirring tank and the pressure-bearing type liquid material tank device, volatile oil solution is continuously and hermetically conveyed to the high-efficiency atomizing spray head by the pressure-bearing type liquid material tank through compressed air, and the volatile oil solution is uniformly and highly dispersedly sprayed into water-cyclodextrin mixed material liquid of the temperature-controlled stirring tank in a mist shape, so that the high-efficiency dispersion, stirring and inclusion operations of the volatile oil are realized.
2. The volatile oil is subjected to primary dispersion by the efficient atomizing nozzle device, the generated volatile oil droplets are fine and uniform, and can be dispersed in time and efficiently at the initial moment when the volatile oil droplets are sprayed to the 'water-cyclodextrin' mixed material liquid, so that the occurrence of segregation is avoided, and the inclusion rate and the yield of the inclusion compound are improved.
3. The invention adds a spiral auxiliary stirrer on one side of the main stirrer in the temperature control type stirring tank. Through the vertical and horizontal matching stirring of the main stirrer and the auxiliary stirrer, the stirring process becomes a three-dimensional mixing process, the stirring time is shortened, and the stirring and inclusion effects are optimized.
4. The volatile oil adding device disclosed by the invention completes the adding work of the volatile oil by utilizing the pressure-bearing liquid tank, realizes the automation and controllability of the adding of the volatile oil, improves the adding efficiency of the volatile oil and saves the labor cost.
Drawings
FIG. 1 is a schematic structural view of a volatile oil spraying, stirring and clathrating device
The scores in the figures are as follows: a temperature control type stirring tank-1; a high-efficiency atomizing spray head-2; a pressure-bearing liquid tank-3; an air compression conduit-4; a first air pressure regulating valve-5; an electromagnetic flow control valve-6; a liquid inlet pipe-7; a liquid pipe-8; an open liquid baffle-9; a main stirrer-10; a helical auxiliary stirrer-11; a variable frequency speed regulator-12; a second air pressure regulating valve-13; pressure gauge-14; and (4) manually opening and closing a valve-15.
FIG. 2 is a schematic view of a spray gun
The scores in the figures are as follows: a high-efficiency atomizing spray head-2; an air compression conduit-4; a first air pressure regulating valve-5; an electromagnetic flow control valve-6; a liquid inlet pipe-7.
Detailed Description
The following describes in further detail embodiments of the present invention with reference to the accompanying drawings.
Example 1 volatile oil spraying, stirring and clathrating device structure and operation mode
As shown in the attached figure 1, the volatile oil spraying, stirring and clathrating device mainly comprises a temperature-controlled stirring tank 1, a high-efficiency atomizing spray head 2 and a pressure-bearing type liquid tank 3, and is characterized in that the high-efficiency atomizing spray head 2 is arranged at the top of the tank body of the temperature-controlled stirring tank 1, and the pressure-bearing type liquid tank 3 is communicated with a liquid inlet pipe 7 of the high-efficiency atomizing spray head 2 through a liquid pipe 8.
As shown in fig. 2, an air pressure conduit 4 is arranged at the upper part of the high-efficiency atomizing nozzle 2, and a first air pressure regulating valve 5 is arranged on the air pressure conduit 4. Meanwhile, the electromagnetic flow regulating valve 6 is arranged in the middle of the high-efficiency atomizing spray head 2, and the atomizing frequency, the atomizing time and the atomizing degree of the high-efficiency atomizing spray head 2 can be regulated and controlled through the electromagnetic flow regulating valve 6. The spout of the high-efficiency atomizing nozzle 2 is provided with an open liquid baffle 9.
In the invention, the top of the tank body of the temperature control type stirring tank 1 is provided with a main stirrer 10, and the right side of the main stirrer is provided with a spiral shape. The main stirrer 10 and the helical auxiliary stirrer 11 are controlled by a variable frequency speed regulator 12, and the stirring speed and the rotation direction can be adjusted and controlled. The upper part of the pressure-bearing type liquid tank 3 is provided with a second air pressure regulating valve 13 and a pressure gauge 14, and the bottom of the pressure-bearing type liquid tank 3 is provided with a manual switch valve 15.
When the volatile oil inclusion operation is carried out, the manual switch valve 15 of the pressure-bearing type liquid material tank 3 is kept in a closed state, meanwhile, the second air pressure regulating valve 13 is closed, and the volatile oil or the volatile oil ethanol solution is added into the pressure-bearing type liquid material tank 3. And (3) opening a second air pressure regulating valve 13, pressurizing the pressure-bearing type liquid tank 3 to a specified pressure range, opening a manual switch valve 15, and enabling the volatile oil to enter the efficient atomizing nozzle 2 along the liquid pipe 8 and the liquid inlet pipe 7 under the pushing of pressure difference. At the moment, the first air pressure regulating valve 5 is opened to carry out secondary pressurization on the volatile oil entering the high-efficiency atomizing nozzle 2, and meanwhile, the electromagnetic flow regulating valve 6 in the middle of the high-efficiency atomizing nozzle 2 is opened to control the spraying frequency and the spraying time of the high-efficiency atomizing nozzle 2.
The high-efficiency atomizing spray head 2 uniformly sprays the volatile oil or the volatile oil ethanol solution into the tank body of the temperature-controlled stirring tank 1 in a highly dispersed atomizing state, and the volatile oil or the volatile oil ethanol solution is efficiently stirred with the water-cyclodextrin mixed material liquid. During stirring, the stirring blades on the main stirrer 10 are large and rotate at a low speed, and are stirred in a forward rotation manner, and the generated stirring force is upward; the helical auxiliary agitator 11 has a small helical cross section and a large rotation speed, and performs reverse agitation with the generated agitation force directed downward. The main stirrer 10 and the spiral auxiliary stirrer 11 are matched with each other in a vertical and vertical mixing manner, so that the vertical flow of the liquid medicine is increased, the mixing process becomes a three-dimensional mixing process, the mixing is more sufficient and uniform, an ideal mixing effect is achieved, and the efficient dispersion, mixing and inclusion operation of the volatile oil is realized.
Example 2 study on inclusion rate and yield of stirring inclusion compound of Chaihei granule volatile oil
1 Material
1.1 instruments TCS-30 type electronic platform scale (Mettler-Torlando Co.), QT-2 type straight-tube multifunctional extraction tank (Shanghai Yuanjun pharmaceutical machinery Co., Ltd.), BJG-60 type electric heating stirring heat preservation tank (Wenzhou pharmaceutical equipment factory), SHB-B95 type circulating water type multipurpose vacuum pump (Zhenzhou Changcheng Kogyo Co., Ltd.), GZX-9240MBE type electric heating constant temperature blast drying box (Shanghai Boxun Kogyo Co., Ltd.), SD600 type three-foot hanging bag centrifuge (Zhangjia City hong Ganghong centrifuge manufacturing Co., Ltd.), XS204 type electronic analytical balance (Mettler-Torlando Co., Ltd.).
1.2 reagent and drug beta-cyclodextrin (Waxing Biochemical Co., Ltd., Mengzhou, batch No. 20190201); 7 raw medicinal materials of bupleurum, honeysuckle, sweet wormwood herb, weeping forsythia, fineleaf schizonepeta herb, mint and heartleaf houttuynia herb are provided by Lunan Kangpu pharmaceutical Co., Ltd and all meet the regulation of various items of Chinese pharmacopoeia (2015 edition).
2. Method of producing a composite material
2.1 extraction of volatile oil according to the dosage of traditional Chinese medicinal materials in the prescription of the Chaiyinggranule, 20kg of radix bupleuri, 15kg of honeysuckle, 15kg of sweet wormwood herb, 15kg of fructus forsythiae, 10kg of herba schizonepetae, 15kg of mint and 15kg of houttuynia cordata are weighed, put into a multifunctional extraction tank, added with 10 times of drinking water, soaked for 1h, heated by interlayer steam, kept slightly boiling by controlling the steam pressure, distilled and extracted for 4h to obtain 266mL of mixed volatile oil, and stored at 4 ℃ for later use.
2.2 preparation of the volatile oil clathrate compound, 200mL of mixed volatile oil is taken, and the mixed volatile oil is diluted by medicinal ethanol with the same volume to prepare a volatile oil ethanol solution. And taking 160mL of the volatile oil ethanol solution, totaling 2 parts, and preparing the corresponding volatile oil clathrate compound according to the following dropping saturated aqueous solution method and spraying saturated aqueous solution method respectively.
A. Dropping saturated aqueous solution method
According to the weight ratio of beta-cyclodextrin and volatile oil ethanol solution 1: 5 weighing 800g of beta-cyclodextrin for later use; mixing water and beta-cyclodextrin 16: adding 12.8L of purified water into an electric heating stirring heat-preserving tank according to the proportion of 1, starting a stirrer, setting the temperature to be 50 ℃, slowly adding beta-cyclodextrin, and stirring to dissolve; the volatile oil ethanol solution is placed in a 250mL separating funnel, slowly dripped into the beta-cyclodextrin water solution at the dripping speed of 120-180 drops/min, the stirring is carried out while dripping, the temperature is kept at 50 ℃, and the stirring is continued for 2 hours after the dripping is finished; and transferring the inclusion solution into a stainless steel container, performing cold precipitation for 24 hours at the temperature of 0-4 ℃, filtering, collecting precipitates, and drying in an oven at the temperature of 40 ℃ for 12 hours to obtain the inclusion compound I.
B. Spraying saturated aqueous solution method
Volatile oil inclusion is carried out by adopting the inclusion device. According to the weight ratio of beta-cyclodextrin and volatile oil ethanol solution 1: weighing 800g of beta-cyclodextrin according to the proportion of 5(g/mL) for later use; mixing water and beta-cyclodextrin 16: adding 12.8L of purified water into an electric heating stirring heat-preserving tank according to the proportion of 1, starting a stirrer, setting the temperature to be 50 ℃, slowly adding beta-cyclodextrin, and stirring to dissolve; uniformly spraying the volatile oil ethanol solution into the beta-cyclodextrin water solution at the spraying speed of 12-18 mL/min, stirring while spraying, keeping the temperature at 50 ℃, and continuing stirring for 2 hours after the spraying is finished; and transferring the inclusion solution into a stainless steel container, performing cold precipitation for 24 hours at the temperature of 0-4 ℃, filtering, collecting the precipitate, and drying in an oven at the temperature of 40 ℃ for 12 hours to obtain an inclusion compound II.
2.3 evaluation index of clathration Effect A certain amount of fine powder of clathration compound is weighed, placed in a 500mL round-bottom flask, added with 300mL of purified water and a plurality of glass beads, connected with a volatile oil extraction device, and extracted according to the first method under the section 2204 'volatile oil determination method' in the national pharmacopoeia (four) of 2015 edition, and the clathration rate of the volatile oil is calculated. Meanwhile, 2mL of mixed volatile oil is precisely absorbed, the operation is carried out in the same method, parallel tests are carried out for 3 times, and the blank recovery rate is calculated. Wherein, the yield, inclusion rate and blank recovery rate of the volatile oil inclusion compound are calculated according to the following formulas:
the inclusion rate is used as a main index for evaluating the inclusion effect, the higher the value is, the better the inclusion effect of the volatile oil is, the stability of the volatile oil can be effectively improved, and the stability of the preparation is further facilitated, so the weight coefficient is determined to be 0.7; the inclusion compound yield is also significant in actual production, but when too much auxiliary materials are added, the production cost is increased, and the preparation forming is influenced, so that the auxiliary materials are used as secondary investigation indexes, and the weight coefficient is determined to be 0.3, therefore, the comprehensive score is equal to the inclusion rate of the volatile oil multiplied by 0.7+ the inclusion compound yield multiplied by 0.3.
3 results
The inclusion rate and yield of the stirring inclusion compound of the firewood and silver particles volatile oil are shown in table 1.
TABLE 12 comparison of Inclusion Effect of volatile oils
Compared with a method of dripping saturated aqueous solution, the inclusion rate and the yield of the inclusion compound prepared by adopting the spraying and saturated aqueous solution method are higher, and the comprehensive score is more excellent, which shows that the spraying and adding method is favorable for improving the inclusion rate and the yield of the volatile oil inclusion compound, and the inclusion effect is optimized.
Claims (9)
1. The utility model provides a volatile oil spraying stirring inclusion device, mainly comprises control by temperature change formula agitator tank (1), high-efficient atomizer (2) and pressure-bearing formula liquid material jar (3), its characterized in that, the jar body top of control by temperature change formula agitator tank (1) is provided with high-efficient atomizer (2), and pressure-bearing formula liquid material jar (3) keep the UNICOM through feed liquor pipe (7) of liquid material pipe (8) and high-efficient atomizer (2).
2. The volatile oil spraying, stirring and clathrating device as claimed in claim 1, wherein an air pressure guide pipe (4) is arranged at the upper part of the high-efficiency atomizing nozzle (2), and a first air pressure regulating valve (5) is arranged on the air pressure guide pipe (4).
3. The volatile oil spraying, stirring and clathrating device as claimed in claim 2, wherein the middle of the high-efficiency atomizing nozzle (2) is provided with an electromagnetic flow control valve (6), and the spraying frequency, the spraying time and the atomizing degree of the high-efficiency atomizing nozzle (2) can be controlled by the electromagnetic flow control valve (6).
4. The volatile oil spraying, stirring and clathrating device as claimed in any one of claims 1-3, wherein an open liquid baffle (9) is arranged at the nozzle of the high-efficiency atomizing nozzle (2).
5. The volatile oil spraying, stirring and clathrating device as claimed in any one of claims 1-3, wherein a main stirrer (10) is arranged at the top of the temperature-controlled stirring tank (1), and a spiral auxiliary stirrer (11) is arranged at the right side of the temperature-controlled stirring tank.
6. The volatile oil spraying, stirring and clathrating device as claimed in claim 5, wherein the main stirrer (10) and the helical auxiliary stirrer (11) are controlled by a variable frequency speed regulator (12) which can regulate and control the stirring speed and the rotation direction.
7. The volatile oil spraying, stirring and clathrating device as claimed in claim 6, wherein the main stirrer (10) and the helical auxiliary stirrer (11) rotate in opposite directions, the rotation speed of the main stirrer (10) is 50-70r/min, and the rotation speed of the helical auxiliary stirrer (11) is 250-350 r/min.
8. The volatile oil spraying, stirring and clathrating device as claimed in claim 6, characterized in that the rotation speed of the main stirrer (10) is 55r/min, and the rotation speed of the helical auxiliary stirrer (11) is 325 r/min.
9. The volatile oil spraying, stirring and clathrating device as claimed in any one of claims 1-3, wherein a second air pressure regulating valve (13) and a pressure gauge (14) are arranged at the upper part of the pressure-bearing type liquid tank (3), and a manual switch valve (15) is arranged at the bottom of the pressure-bearing type liquid tank (3).
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011510591.9A CN112473435A (en) | 2020-12-18 | 2020-12-18 | Volatile oil spraying, stirring and clathrating device |
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| CN202011510591.9A CN112473435A (en) | 2020-12-18 | 2020-12-18 | Volatile oil spraying, stirring and clathrating device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113288866A (en) * | 2021-07-12 | 2021-08-24 | 山东诺明康药物研究院有限公司 | Antibacterial eye drops and preparation method thereof |
| CN113731256A (en) * | 2021-07-20 | 2021-12-03 | 江苏莹华生物制药有限公司 | Traditional Chinese medicine volatile oil inclusion equipment for high-efficiency curative effect exertion of traditional Chinese medicine |
-
2020
- 2020-12-18 CN CN202011510591.9A patent/CN112473435A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113288866A (en) * | 2021-07-12 | 2021-08-24 | 山东诺明康药物研究院有限公司 | Antibacterial eye drops and preparation method thereof |
| CN113731256A (en) * | 2021-07-20 | 2021-12-03 | 江苏莹华生物制药有限公司 | Traditional Chinese medicine volatile oil inclusion equipment for high-efficiency curative effect exertion of traditional Chinese medicine |
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