CN112451859A - Brain glioma photodynamic direct irradiation treatment device - Google Patents
Brain glioma photodynamic direct irradiation treatment device Download PDFInfo
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- CN112451859A CN112451859A CN202011324473.9A CN202011324473A CN112451859A CN 112451859 A CN112451859 A CN 112451859A CN 202011324473 A CN202011324473 A CN 202011324473A CN 112451859 A CN112451859 A CN 112451859A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0626—Monitoring, verifying, controlling systems and methods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/063—Radiation therapy using light comprising light transmitting means, e.g. optical fibres
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0632—Constructional aspects of the apparatus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0654—Lamps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0664—Details
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Abstract
The invention discloses a brain glioma photodynamic direct irradiation treatment device which comprises a main body device, wherein the main body device comprises a base, two mounting grooves are fixedly arranged on the top of the base, a photodynamic device and an auxiliary device are respectively and fixedly arranged on the two mounting grooves, the photodynamic device and the auxiliary device respectively comprise an outer box body and a controller, a shunting seat is fixedly arranged on the top of the photodynamic device, an optical fiber interface is fixedly arranged on one side of the shunting seat, a telescopic connecting pipe is fixedly arranged on the top of the shunting seat, a fixing pipe is fixedly arranged on the top of the telescopic connecting pipe, and a light energy lampshade is fixedly arranged on one side of the fixing pipe. This kind of cerebral glioma photodynamic direct irradiation treatment device, simple structure is reasonable, and the modern design makes a beam of light disperse spherical light source through dispersion medium, shines disease position, can real-time supervision intracranial pressure condition through the pressure control pipe, avoids the too high cerebral hernia that causes of pressure.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a brain glioma photodynamic direct irradiation treatment device.
Background
Photodynamic therapy is a new technology for disease diagnosis and treatment using the photodynamic effect. The basis of action is the photodynamic effect. This is a photosensitizing reaction with biological effects involving oxygen molecules. The process is that the laser irradiation with specific wavelength excites the photosensitizer absorbed by the tissue, and the excited photosensitizer transfers the energy to the surrounding oxygen to generate singlet oxygen with strong activity, and the singlet oxygen and the adjacent biological macromolecules generate oxidation reaction to generate cytotoxicity, thereby causing cell damage and death. Until now, many hospitals have adopted photodynamic therapy to diagnose and treat tumors clinically, and in addition, many other units are researching the tumors, such as Xibo, which is a photosensitizer for tumor diagnosis and treatment, and Ella, which is used for treating condyloma acuminatum, acne, nevus flammeus (Hemiprofen), and the like.
Because the conventional photodynamic therapy scheme has the defects of long brain tissue exposure time in operation, long light-shielding time after operation, systemic side effect after the photosensitizer is intravenously administered, unrepeatable application and the like, the method for photodynamic therapy of the brain glioma can not be popularized later. Therefore, the brain glioma photodynamic direct irradiation treatment device is improved.
Disclosure of Invention
In order to solve the technical problems, the invention provides the following technical scheme:
the invention relates to a brain glioma photodynamic direct irradiation treatment device, which comprises:
the main body device comprises a base, wherein two mounting grooves are fixedly arranged at the top of the base, a photodynamic device and an auxiliary device are respectively and fixedly arranged in the two mounting grooves, the photodynamic device and the auxiliary device both comprise an outer box body and a controller, a shunt seat is fixedly arranged at the top of the photodynamic device, an optical fiber interface is fixedly arranged on one side of the shunt seat, a telescopic connecting pipe is fixedly arranged at the top of the shunt seat, a fixed pipe is fixedly arranged at the top of the telescopic connecting pipe, an optical energy lampshade is fixedly arranged on one side of the fixed pipe, a device groove is fixedly arranged at the top of the auxiliary device, a protective cover is fixedly arranged on one side of the device groove, and a connecting port is fixedly arranged in the device groove;
treatment device, treatment device includes the multicavity sleeve pipe, the inside respectively fixed mounting of multicavity sleeve pipe has outer drainage tube, dispersion medium input output tube, pellicle carrier tube, pressure control pipe and optic fibre pipe, multicavity sleeve pipe shaft fixed mounting has fixed cover, fixed cover one side fixed mounting has the adjustable ring.
As a preferred technical scheme, four corners of the bottom of the base are fixedly provided with movable rollers, one side of the base is fixedly provided with an anti-collision column, a wheel shaft of each movable roller is fixedly provided with a brake pedal and a damping spring, the rollers of the movable rollers are made of high polymer rubber, and the other side of the base is fixedly provided with a power supply interface.
As a preferred technical solution of the present invention, a power port for supplying power to the photodynamic device and the auxiliary device is fixedly disposed inside the mounting groove, and a sealing rubber ring is fixedly disposed at a connection position of the mounting groove and the photodynamic device and the auxiliary device.
As a preferred technical scheme of the invention, a drainage box body, a dispersion medium storage box, a dispersion medium recovery box and a pressure regulating box are fixedly arranged in the auxiliary device, and an access door is fixedly arranged on the other side of the auxiliary device.
As a preferred technical scheme of the present invention, a drainage pump is fixedly installed inside the drainage box body, a bidirectional extraction pump is fixedly installed on the tops of the drainage pump, the dispersion medium storage box and the dispersion medium recovery box, shunt tubes are respectively and fixedly installed on two sides of the bidirectional extraction pump, a pressure regulator is fixedly installed inside the pressure regulation box, connecting pipes are fixedly installed on the drainage pump, the bidirectional extraction pump and the pressure regulator, and the connecting pipes are fixedly connected with one side of the connecting port.
As a preferred technical scheme of the invention, the protective cover is fixedly arranged on one side of the auxiliary device through a screw, a sealing rubber ring is fixedly arranged at the joint of the protective cover and the top of the auxiliary device, and a sterilizing lamp is fixedly arranged in the device groove.
As a preferred technical scheme of the invention, the connecting ports respectively comprise an external drainage tube connecting port, a dispersion medium input and output tube connecting port and a pressure control tube connecting port.
As a preferred technical scheme of the invention, the semipermeable membrane bearing tube is fixedly provided with a matched semipermeable membrane, the semipermeable membrane polysulfone membrane is provided with holes which allow oxygen and photosensitizer to pass through but not allow dispersion medium to pass through, the hole diameter is changed within the range of (1-20) multiplied by 10-3 mu m, the range of the intercepted relative molecular mass is equivalent to the range of 1000-500000, and the dispersion medium input-output tube and the optical fiber tube are fixedly connected in the semipermeable membrane bearing tube.
The invention has the beneficial effects that:
1. according to the cerebral glioma photodynamic direct irradiation treatment device, an outer drainage tube, a dispersion medium input and output tube, a semipermeable membrane bearing tube, a pressure control tube and an optical fiber tube are respectively and fixedly arranged in a multi-cavity sleeve, a fixing cover is fixedly arranged on the surface of a shaft of the multi-cavity sleeve, an adjusting ring is fixedly arranged on one side of the fixing cover, the multi-cavity sleeve is fixed at a lesion part of a patient through the fixing cover, the stability of the device in the treatment process is ensured, medical accidents caused by unnecessary shaking are avoided, a beam of light is dispersed into a spherical light source through the dispersion medium to irradiate the part of the patient, the intracranial pressure condition can be monitored in real time through the pressure control tube, and cerebral hernia caused by overhigh pressure is;
2. this kind of glioma photodynamic direct irradiation treatment device, it is fixed to be provided with supporting pellicle to state the pellicle carrier tube, pellicle polysulfone membrane is made, be equipped with on it and allow oxygen and photosensitizer to pass through, and the hole that dispersion medium passes through is not allowed, pellicle 5 comprises polysulfone membrane, mechanical strength is good, heat-resisting, chemical property is stable, characteristics such as by bacterial contamination, its aperture range is wide simultaneously, the aperture can be in (1 ~ 20) x 10-3 mu m within range changes, intercept relative molecular mass in other words from the range of 1000 ~ 500000, thereby promote therapeutic effect, promote therapeutic effect.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention. In the drawings:
FIG. 1 is a perspective view of a main body device of a photodynamic direct irradiation therapy device for brain glioma;
FIG. 2 is a perspective view of a device for photodynamic direct irradiation of brain glioma in accordance with the present invention;
FIG. 3 is a perspective view of a base of a photodynamic direct irradiation therapy device for glioma of the present invention;
FIG. 4 is a perspective view of an auxiliary device of the photodynamic direct irradiation therapy device for glioma;
fig. 5 is a schematic view of the internal structure of an auxiliary device of the photodynamic direct irradiation treatment device for brain glioma.
In the figure: 1. a main body device; 2. a base; 3. mounting grooves; 4. a photodynamic device; 5. an auxiliary device; 6. a controller; 7. a shunt seat; 8. an optical fiber interface; 9. a telescopic connecting pipe; 10. a fixed tube; 11. a light energy lampshade; 12. a device slot; 13. a protective cover; 14. a connection port; 15. a treatment device; 16. a multi-lumen cannula; 17. an outer drainage tube; 18. inputting the dispersion medium into an output pipe; 19. a semipermeable membrane support tube; 20. a pressure control tube; 21. a fixed cover; 22. an adjusting ring; 23. moving the roller; 24. a drainage box body; 25. a dispersion medium storage box; 26. a dispersion medium recovery box; 27. a pressure regulating tank; 28. a drainage pump; 29. a bi-directional pumping pump; 30. a pressure regulator; 31. a sterilizing lamp; 32. an optical fiber tube.
Detailed Description
The preferred embodiments of the present invention will be described in conjunction with the accompanying drawings, and it will be understood that they are described herein for the purpose of illustration and explanation and not limitation.
Example (b): as shown in fig. 1 to 5, the present invention provides a photodynamic direct irradiation therapy apparatus for brain glioma, comprising:
the main body device 1 comprises a base 2, mounting grooves 3 are fixedly mounted at the top of the base 2, the mounting grooves 3 are fixedly provided with two, a photodynamic device 4 and an auxiliary device 5 are respectively and fixedly mounted on the two mounting grooves 3, the photodynamic device 4 and the auxiliary device 5 both comprise an outer box body and a controller 6, a shunt seat 7 is fixedly mounted at the top of the photodynamic device 4, an optical fiber interface 8 is fixedly mounted at one side of the shunt seat 7, a telescopic connecting pipe 9 is fixedly mounted at the top of the shunt seat 7, a fixed pipe 10 is fixedly mounted at the top of the telescopic connecting pipe 9, an optical energy lampshade 11 is fixedly mounted at one side of the fixed pipe 10, a device groove 12 is fixedly mounted at the top of the auxiliary device 5, a protective cover 13 is fixedly mounted at one side of the device groove 12, and;
the treatment device 15, the treatment device 15 includes the multi-lumen cannula 16, the multi-lumen cannula 16 is internally and fixedly provided with the external drainage tube 17, the dispersion medium input and output tube 18, the semipermeable membrane bearing tube 19, the pressure control tube 20 and the optical fiber tube 32, the surface of the shaft body of the multi-lumen cannula 16 is fixedly provided with the fixed cover 21, and one side of the fixed cover 21 is fixedly provided with the adjusting ring 22.
Wherein, base 2 bottom four corners fixed mounting has removal gyro wheel 23, and base 2 one side fixed mounting has the bumping post, removes 23 fixed brake pedals and the damping spring of being provided with of shaft department of gyro wheel, and the gyro wheel that removes gyro wheel 23 adopts the polymer rubber material, and 2 opposite sides fixed mounting of base has power source.
Wherein, the inside fixed power port that is provided with the power supply and gives photodynamic device 4 and auxiliary device 5 of mounting groove 3, the fixed sealing rubber circle that is provided with of mounting groove 3 and photodynamic device 4 and auxiliary device 5 junction.
Wherein, the inside of the auxiliary device 5 is fixedly provided with a drainage box body 24, a dispersion medium storage box 25, a dispersion medium recovery box 26 and a pressure regulating box 27, and the other side of the auxiliary device 5 is fixedly provided with an access door.
The drainage box body 24 is fixedly provided with a drainage pump 28, the dispersion medium storage box 25 and the dispersion medium recovery box 26, the top of the two-way extraction pump 29 is fixedly provided with a two-way extraction pump 29, two sides of the two-way extraction pump 29 are respectively and fixedly provided with a shunt tube, the pressure regulator 27 is fixedly provided with a pressure regulator 30, the drainage pump 28, the two-way extraction pump 29 and the pressure regulator 30 are all fixedly provided with connecting tubes, and the connecting tubes are fixedly connected with one side of the connecting port 14.
Wherein, protective cover 13 passes through screw fixed mounting in auxiliary device 5 one side, and protective cover 13 is provided with the sealed rubber ring with 5 top junctions are fixed, and device groove 12 inside fixed mounting has sterilamp 31.
Wherein, the connection port 14 comprises an external drainage tube connection port, a dispersion medium input and output tube connection port and a pressure control tube connection port respectively.
Wherein, the semipermeable membrane bearing tube 19 is fixedly provided with a matched semipermeable membrane, the semipermeable membrane is made of a polysulfone membrane, holes which allow oxygen and photosensitizer to pass through but not allow dispersion medium to pass through are arranged on the semipermeable membrane bearing tube 19, the aperture is changed within the range of (1-20) multiplied by 10-3 μm, which is equivalent to the range of intercepting the relative molecular mass from 1000-500000, and the dispersion medium input and output tube 18 and the optical fiber tube 32 are fixedly connected in the semipermeable membrane bearing tube 19.
The working principle is as follows: the user firstly connects the external drainage tube 17, the dispersion medium input and output tube 18, the pressure control tube 20 and the optical fiber tube 32 of the treatment device 15 with the external drainage tube connecting port, the dispersion medium input and output tube connecting port, the pressure control tube connecting port and the optical fiber interface of the photodynamic device 4 of the auxiliary device 5 respectively, puts the multi-cavity cannula 16 at one side of the fixed cover 21 into the lesion of the patient through the adjusting ring 22, simultaneously starts the photodynamic device 4 and the auxiliary device 5 through the controller 6, starts the treatment of the intracranial cavity cannula 16 under the fixation of the fixed cover 21, and the dispersion medium input and output tube 18 and the optical fiber tube 32 are fixedly connected in the semipermeable membrane bearing 19 tube; the semi-permeable membrane is fixedly connected with the end part of the semi-permeable membrane bearing pipe 19, the front end parts of the dispersion medium input and output pipe 18 and the optical fiber pipe 32 are wrapped in the semi-permeable membrane, the light dispersion medium, oxygen and photosensitizer can be stored through the semi-permeable membrane, and the photosensitizer can permeate outwards in the semi-permeable membrane; the optical fiber transmits the spherical light source into the semi-permeable membrane, and a beam of light is dispersed into the spherical light source through the dispersion medium to irradiate the affected part; the pressure control tube 20 can monitor the intracranial pressure condition in real time to avoid the cerebral hernia caused by overhigh pressure, the tail end of the external drainage tube 17 and the tail end of the dispersion medium input and output tube 18 work under the action of the flow pump 28 and the bidirectional extraction pump 29, the pressure control tube 20 keeps the intracranial pressure of the brain to work within an allowable pressure range all the time, the optical fiber tube 32 introduces a light source into the semipermeable membrane and scatters the light to the affected part under the action of the light dispersion medium, after the treatment operation is finished, the pressure control tube 20 performs intracranial pressure coordination control under the action of the pressure regulator 30, the dispersion medium input and output tube 18 sucks out the dispersion medium through the bidirectional extraction pump 29, the recovered waste liquid is conveyed to the temporal part of the dispersion medium recycling box 26, the balloon-like semipermeable membrane retracts, and simultaneously, the tumor cavity is flushed by physiological saline under the driving of the flow pump 28 through the external drainage tube 17, and the drugs such as photosensitizer which do not enter the tumor cells, finally, the intracranial multilumen cannula 16 is removed.
Finally, it should be noted that: in the description of the present invention, it should be noted that the terms "vertical", "upper", "lower", "horizontal", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of describing the present invention and simplifying the description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention.
In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly and may, for example, be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (8)
1. A glioma photodynamic direct irradiation treatment device comprising:
the main body device (1), the main body device (1) comprises a base (2), the top of the base (2) is fixedly provided with two mounting grooves (3), the two mounting grooves (3) are respectively fixedly provided with a photodynamic device (4) and an auxiliary device (5), the photodynamic device (4) and the auxiliary device (5) both comprise an outer box body and a controller (6), the top of the photodynamic device (4) is fixedly provided with a shunt seat (7), one side of the shunt seat (7) is fixedly provided with an optical fiber interface (8), the top of the shunt seat (7) is fixedly provided with a telescopic connecting pipe (9), the top of the telescopic connecting pipe (9) is fixedly provided with a fixed pipe (10), one side of the fixed pipe (10) is fixedly provided with an optical energy lampshade (11), the top of the auxiliary device (5) is fixedly provided with a device groove (12), a protective cover (13) is fixedly arranged on one side of the device groove (12), and a connecting port (14) is fixedly arranged in the device groove (12);
treatment device (15), treatment device (15) include multicavity sleeve pipe (16), multicavity sleeve pipe (16) inside respectively fixed mounting have outer drainage tube (17), dispersion medium input and output pipe (18), pellicle carrier tube (19), pressure control pipe (20) and optical fiber pipe (32), multicavity sleeve pipe (16) axis body fixed surface installs fixed cover (21), fixed cover (21) one side fixed mounting has adjustable ring (22).
2. The brain glioma photodynamic direct irradiation treatment device according to claim 1, wherein four corners of the bottom of the base (2) are fixedly provided with movable rollers (23), one side of the base (2) is fixedly provided with an anti-collision column, a wheel shaft of each movable roller (23) is fixedly provided with a brake pedal and a damping spring, rollers of the movable rollers (23) are made of polymer rubber, and the other side of the base (2) is fixedly provided with a power supply interface.
3. The brain glioma photodynamic direct irradiation treatment device according to claim 1, wherein a power port for supplying power to the photodynamic device (4) and the auxiliary device (5) is fixedly arranged in the mounting groove (3), and a sealing rubber ring is fixedly arranged at the joint of the mounting groove (3) and the photodynamic device (4) and the auxiliary device (5).
4. The brain glioma photodynamic direct irradiation treatment device according to claim 1, wherein a drainage box body (24), a dispersion medium storage box (25), a dispersion medium recovery box (26) and a pressure regulating box (27) are fixedly arranged in the auxiliary device (5), and an access door is fixedly arranged on the other side of the auxiliary device (5).
5. The device for photodynamic direct irradiation therapy of brain glioma according to claim 4, wherein a drainage pump (28) is fixedly installed inside the drainage box body (24), the drainage pump (28), the top of the dispersion medium storage box (25) and the top of the dispersion medium recovery box (26) are fixedly provided with a bidirectional extraction pump (29), two sides of the bidirectional extraction pump (29) are respectively and fixedly provided with a shunt tube, a pressure regulator (30) is fixedly installed inside the pressure regulation box (27), and the drainage pump (28), the bidirectional extraction pump (29) and the pressure regulator (30) are respectively and fixedly provided with a connecting pipe which is fixedly connected with one side of the connecting port (14).
6. The photodynamic direct irradiation therapy device for brain glioma according to claim 1, wherein the protective cover (13) is fixedly installed at one side of the auxiliary device (5) by screws, a sealing rubber ring is fixedly arranged at the joint of the protective cover (13) and the top of the auxiliary device (5), and the sterilizing lamp (31) is fixedly installed inside the device groove (12).
7. The photodynamic direct irradiation therapy device for brain glioma of claim 1 wherein said connection ports (14) include an external drainage tube connection port, a dispersion medium input and output tube connection port and a pressure control tube connection port, respectively.
8. The photodynamic direct irradiation therapy device for brain glioma according to claim 1, wherein the semipermeable membrane carrier tube (19) is fixedly provided with a matched semipermeable membrane, the semipermeable membrane is made of polysulfone membrane, holes which allow oxygen and photosensitizer to pass through but not allow dispersion medium to pass through are formed in the semipermeable membrane carrier tube (19), the hole diameter is changed within the range of (1-20) x 10-3 μm, which is equivalent to the range of the intercepted relative molecular mass from 1000-500000, and the dispersion medium input and output tube (18) and the optical fiber tube (32) are fixedly arranged in the semipermeable membrane carrier tube (19).
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| CN202011324473.9A CN112451859A (en) | 2020-11-23 | 2020-11-23 | Brain glioma photodynamic direct irradiation treatment device |
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| CN211188506U (en) * | 2019-08-14 | 2020-08-07 | 昆明医科大学第二附属医院 | Multi-functional pancreas wound peritoneal irrigation device |
| CN211214998U (en) * | 2019-12-07 | 2020-08-11 | 威海众恒医疗设备有限公司 | Cart type bone wound therapeutic apparatus |
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