CN112450857A - Micro intelligent capsule for gastrointestinal examination, pH value positioning and targeted quantitative drug delivery - Google Patents
Micro intelligent capsule for gastrointestinal examination, pH value positioning and targeted quantitative drug delivery Download PDFInfo
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- 229940079593 drug Drugs 0.000 claims abstract description 30
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- 238000000338 in vitro Methods 0.000 claims abstract description 8
- 229940126585 therapeutic drug Drugs 0.000 claims abstract description 7
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- 238000012545 processing Methods 0.000 claims description 23
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Images
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- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/041—Capsule endoscopes for imaging
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- A—HUMAN NECESSITIES
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- A61B1/00002—Operational features of endoscopes
- A61B1/00004—Operational features of endoscopes characterised by electronic signal processing
- A61B1/00009—Operational features of endoscopes characterised by electronic signal processing of image signals during a use of endoscope
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- A61B1/273—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes
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- A61B1/31—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the rectum, e.g. proctoscopes, sigmoidoscopes, colonoscopes
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Abstract
The invention discloses an intelligent capsule for micro gastrointestinal examination, pH value positioning and targeted quantitative drug delivery, which comprises a capsule body, wherein the capsule body consists of a functional cabin, an operation cabin and a drug cabin, the functional cabin is used for acquiring images, temperature and pH information in intestines and stomach and wirelessly transmitting the information to an in-vitro wireless receiving device and receiving an operation instruction transmitted by the in-vitro wireless receiving device, the functional cabin transmits a drug delivery instruction to the operation cabin, and electric energy is generated by deformation to maintain the normal operation of a system; the operation cabin is used for receiving the medicine application instruction transmitted by the functional cabin and quantitatively releasing the medicine; a drug compartment to store therapeutic drugs. The capsule can carry out conventional photographing examination on the stomach and the intestinal tract, can also carry out positioning and quantitative administration according to the pH value in the intestine and the stomach, and can also detect the rhythmic contraction of the stomach to provide data support for diagnosis; the capsule can generate current and voltage under the action of peristalsis of stomach and intestinal tract to provide additional electric energy.
Description
Technical Field
The invention relates to the field of intelligent medicine, in particular to an intelligent capsule for micro gastrointestinal examination, pH value positioning and targeted quantitative drug delivery.
Background
The endoscope is a detection instrument integrating traditional optics, ergonomics, precision machinery, modern electronics, mathematics and software, and integrates an image sensor, an optical lens, light source illumination, a mechanical device and the like. The endoscope can be inserted into stomach through mouth or enter human body through other body cavity channels, and the lesion which can not be displayed by X-ray can be seen by using the endoscope, so that the endoscope is very useful for clinical non-invasive detection. The enteroscope is one of endoscopes, which can be entered through the oral cavity of a patient, and directly reach the stomach and duodenum of the patient, and real-time images of the stomach and duodenum are taken by an image sensor and transmitted to a computer for display through a data transmission line connected with the image sensor.
However, during the insertion process of the gastrointestinal scope into the stomach and duodenum of a patient, the gastrointestinal scope often causes great pain to the patient, and even causes many patients to abandon the examination. In order to solve the problem, israel, a company develops a capsule camera, the capsule camera enters a human body by an oral administration mode and moves forwards along with the peristalsis of intestines and stomach, a miniature camera is fixed in the capsule camera in the moving process to photograph the stomach and the intestinal tract, the photographed picture is sent to an external wireless receiving device in a wireless transmission mode, and a doctor can watch the photographed picture through the wireless receiving device and diagnose the state of an illness of a patient.
The existing capsule camera is composed of an image sensor, a processing chip, a button battery, a wireless sending module and an antenna, wherein the button battery provides electric energy for each electronic element, the image sensor transmits a shot picture to the processing chip, and the processing chip converts the picture into radio waves through the wireless sending module and transmits the radio waves to external receiving equipment through the antenna. The existing capsule camera has the following defects: 1. the button battery has limited electric quantity and has problems in safety, while the capsule camera has poor wireless signal and high electric consumption when moving in the stomach and intestinal tract of a human body, and the interruption of the checking and treating process can occur only by supplying energy by the electric quantity of the button battery; 2. the quantitative administration can not be carried out according to the pH value in the stomach and the intestinal tract; 3. the inability to detect rhythmic contractions of the stomach provides reliable detection data for diagnosis.
Disclosure of Invention
In order to solve the technical problems, the invention designs the intelligent capsule for micro gastrointestinal examination, pH value positioning and targeted quantitative drug delivery, the capsule not only can carry out conventional photographing examination on the stomach and the intestinal tract, but also can carry out quantitative drug delivery according to the pH value and the temperature in the intestine and the stomach, and simultaneously the capsule can also detect the rhythmic contraction of the stomach and provide data support for diagnosis; the capsule can generate current and voltage under the action of peristalsis of the stomach and the intestinal tract, so that additional electric energy is provided for normal operation of the whole capsule, and the interruption of the inspection and administration processes is prevented.
In order to achieve the technical effects, the invention is realized by the following technical scheme:
the intelligent capsule for micro gastrointestinal examination, pH value positioning and targeted quantitative drug delivery comprises a capsule body, wherein the capsule body consists of a functional cabin, an operation cabin and a drug cabin,
the functional cabin is used for acquiring images, temperature and pH information in the intestines and the stomach, wirelessly transmitting the information to the in-vitro wireless receiving equipment and receiving an operation instruction transmitted by the in-vitro wireless receiving equipment, transmitting an application instruction to the operating cabin, and generating electric energy by utilizing deformation to maintain the normal operation of the system;
the operation cabin is used for receiving the medicine application instruction transmitted by the functional cabin and quantitatively releasing the medicine;
a drug compartment to store therapeutic drugs.
Furthermore, the capsule body is of an integrated structure, and the function cabin, the operation cabin and the medicine cabin are formed by separating an isolation layer in the capsule body.
Furthermore, the capsule body be detachable structure, function cabin and operation cabin detachable connection, operation cabin and medicine cabin detachable connection.
Furthermore, an image shooting mechanism, a data processing unit, a power supply unit, a power management unit and a wireless signal receiving and transmitting unit are fixed in the function cabin, a parameter measuring sensor and a deformation power generation mechanism are fixed outside the function cabin, a quantitative pesticide applying mechanism is fixed in the operation cabin, therapeutic drugs are stored in the drug cabin in a sealed mode, the image shooting mechanism, the power supply unit, the power management unit, the wireless signal receiving and transmitting unit, the parameter measuring sensor and the quantitative pesticide applying mechanism are all connected with the data processing unit, and the deformation power generation mechanism is connected with the power management unit.
Furthermore, the image shooting mechanism comprises a light emitting diode, a lens and a CMOS sensor, wherein the light emitting diode is fixed on the periphery of the lens, the lens is fixed in front of the CMOS sensor, and the light emitting diode and the CMOS sensor are both connected with the data processing unit.
Further, the parameter measurement sensor comprises a patch type temperature sensor and a pH sensor, the temperature sensor and the pH sensor are arranged above the function cabin, the deformation power generation mechanism is a piezoelectric film sensor, the piezoelectric film sensor is arranged below the function cabin, the wireless signal receiving and transmitting unit comprises a wireless receiving and transmitting module and a coil type antenna, and the wireless receiving and transmitting module and the antenna are fixed at the bottom of the cavity of the function cabin.
Furthermore, the quantitative pesticide applying mechanism comprises a micro pesticide applying pump and a flowmeter, the micro pesticide applying pump and the flowmeter are fixed in the operation cabin, a pesticide inlet pipe of the micro pesticide applying pump is inserted into the pesticide cabin, the flowmeter is fixed on the pesticide inlet pipe, the micro pesticide applying pump is connected with the data processing unit, and a pesticide outlet pipe of the micro pesticide applying pump is fixed on the cabin surface of the operation cabin and is parallel to the cabin surface.
Furthermore, the medicine cabin is divided into a plurality of medicine cavities by criss-cross grids, the number of the micro medicine delivery pumps is the same as that of the medicine cavities, and the medicine inlet pipes of the micro medicine delivery pumps are inserted into the medicine cavities.
The invention has the beneficial effects that: 1. the capsule can be used for performing conventional photographic examination on stomach and intestinal tract; 2. can be positioned according to the pH value in the intestines and stomach, namely the pH value, and can carry out quantitative pesticide application at the pesticide application part; 3. the capsule is also capable of detecting rhythmic contractions of the stomach to provide data support for diagnosis; 4. the capsule can generate current and voltage under the action of peristalsis of the stomach and the intestinal tract, so that additional electric energy is provided for normal operation of the whole capsule, and the interruption of the inspection and administration processes is prevented.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic diagram of the appearance structure of a micro gastrointestinal examination, pH value positioning and targeted quantitative drug delivery intelligent capsule;
fig. 2 is a schematic sectional structure diagram of the intelligent capsule for micro gastrointestinal examination, pH value positioning and targeted quantitative drug delivery.
In the drawings, the components represented by the respective reference numerals are listed below:
1-a functional cabin, 2-an operation cabin, 3-a medicine cabin, 4-a temperature sensor, 5-a pH sensor, 6-a piezoelectric film sensor, 7-a medicine outlet pipe, 8-a light emitting diode, 9-a lens, 10-a CMOS sensor, 11-a fixing plate, 12-a data processing unit, 13-a power supply management unit, 14-a power supply unit, 15-a wireless transceiving module, 16-an antenna, 17-a micro medicine application pump, 18-a flow meter, 19-a medicine inlet pipe, 20-a grid and 21-a medicine cavity.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
As shown in fig. 1-2, the intelligent capsule for micro gastrointestinal examination, pH value positioning and targeted quantitative drug delivery comprises a capsule body, wherein the capsule body consists of a functional cabin 1, an operation cabin 2 and a drug cabin 3,
the functional cabin 1 is used for acquiring images, temperature and pH information in the intestines and the stomach, wirelessly transmitting the information to an in-vitro wireless receiving device and receiving an operation instruction transmitted by the in-vitro wireless receiving device, transmitting an application instruction to the operation cabin, and generating electric energy by utilizing deformation to maintain the normal operation of the system;
the operation cabin 2 is used for receiving the medicine application instruction transmitted by the functional cabin and quantitatively releasing the medicine;
a drug compartment 3 for storing therapeutic drugs.
The capsule body is of an integrated structure, and the function cabin 1, the operation cabin 2 and the medicine cabin 3 are formed by separating an isolation layer in the capsule body. The capsule body also can be detachable structure, and function cabin 1 is connected with operation cabin 2 sealed plug connection, and operation cabin 2 is connected with 3 sealed plug connections in medicine cabin.
An image shooting mechanism, a data processing unit 12, a power supply unit 13, a power supply management unit and a wireless signal transceiving unit are fixed in the functional cabin 1, a parameter measuring sensor and a deformation power generation mechanism are fixed outside the functional cabin 1, a quantitative drug application mechanism is fixed in the operating cabin 2, therapeutic drugs are stored in the drug cabin 3 in a sealed mode, the power supply unit 14 is composed of a pair of button cells, the image shooting mechanism, the power supply unit 14, the power supply management unit 13, the wireless signal transceiving unit, the parameter measuring sensor and the quantitative drug application mechanism are all connected with the data processing unit 12, and the deformation power generation mechanism is connected with the power supply management unit 13.
The image shooting mechanism comprises a light emitting diode 8, a lens 9 and a CMOS sensor 10, wherein the light emitting diode 8 is fixed on the periphery of the lens 9, the lens 9 is fixed in front of the CMOS sensor 10, and the light emitting diode 8 and the CMOS sensor 10 are both connected with a data processing unit 12.
Wherein, the parameter measurement sensor includes SMD temperature sensor 4 and pH sensor 5, and temperature sensor 4 and pH sensor 5 set up in the top of function cabin 1, and deformation power generation mechanism is a piezoelectric film sensor 6, and piezoelectric film sensor 6 sets up in the below of function cabin 1, wireless signal transceiver unit include wireless transceiver module 15 and coil type antenna 16, wireless transceiver module 15 and antenna 16 are fixed in the intracavity bottom of function cabin 1.
The quantitative pesticide applying mechanism comprises a micro pesticide applying pump 17 and a flow meter 18, the micro pesticide applying pump 17 and the flow meter 18 are fixed in the operation cabin 1, a pesticide inlet pipe 19 of the micro pesticide applying pump 17 is inserted into the pesticide cabin 21, the flow meter 18 is fixed on the pesticide inlet pipe 19, the micro pesticide applying pump 17 is connected with the data processing unit 12, and a pesticide outlet pipe 7 of the micro pesticide applying pump 17 is fixed on the cabin surface of the operation cabin 2 and is flush with the cabin surface.
The medicine cabin 3 is divided into a plurality of medicine cavities 21 by criss-cross grids 20, the number of the micro medicine delivery pumps 17 is the same as that of the medicine cavities 21, and the medicine inlet pipes of the micro medicine delivery pumps are inserted into the medicine cavities.
One specific application of the invention is: orally taking the capsule, the capsule moves forwards under the peristaltic action of the stomach and the intestinal tract, in the moving process, the temperature sensor 4 and the pH sensor at the front end of the functional cabin 1 of the capsule body monitor the temperature value and the pH value information in the gastrointestinal part in real time, the information is transmitted to the data processing unit 12 to be converted into digital signals, the data processing unit transmits the digital signals to the wireless transceiving module 15 to be converted into radio waves and transmits the radio waves to the outside of the body through the antenna 16 so as to be received by the wireless receiving equipment in the outside of the body, and the wireless receiving equipment in the outside of the body can watch pictures and the pH value of the gastrointestinal part after transcoding.
The functional cabin 1 of the capsule body is fixed with a piezoelectric film sensor 6 in an embedded mode, when the piezoelectric film sensor 6 is squeezed and deformed by the stomach, current and voltage are generated at two ends of the piezoelectric film sensor 6 and are transmitted to a power management module 13, the power management module 13 detects the numerical values of the current and the voltage and carries out voltage stabilization and boosting on the numerical values so as to supply power to electronic elements, the power management module 13 transmits the measured current and voltage values to a data processing unit 12, and the data processing unit 12 calculates the rhythmic contraction of the stomach according to the change law of the current and voltage values.
In the process of downward movement of the capsule body from the esophagus to the stomach, the data processing unit 12 can change the pH value of the gastrointestinal tract of a human body according to preset drug delivery standards and a targeted drug delivery program according to different pH values of different parts of the gastrointestinal tract of the human body and the fact that the gastrointestinal tract is locally diseased, when the capsule body reaches different positions of different gastrointestinal tracts, the detected pH value is compared with a normal value, and when the pH value difference is large, the capsule body can carry out positioning drug delivery on the parts, the capsule body utilizes the principle to carry out targeted quantitative control and release of the drugs, and the original systemic drug delivery method is changed into local drug delivery; the safety of medication is improved. Meanwhile, the capsule body can preset the targeted medicine application amount of the capsule body at a certain position of the stomach and intestine part to achieve the purpose of quantitative medicine application, the position of the quantitative medicine application part can be positioned in advance according to the specific pH value of the position, and once the pH value detected by the capsule body is completely different from the pH value of the medicine application part, the quantitative medicine application can be carried out at the position according to the requirement and the externally transmitted medicine application instruction. The quantitative application process of the capsule body is as follows: the data processing unit 12 controls one of the micro drug delivery pumps 17 to suck and release the drug liquid in the drug cavity 21, so as to achieve the purposes of local positioning and quantitative drug delivery, improve the local drug concentration of the patient, improve the drug safety and avoid the systemic adverse reaction caused by large-dose drug delivery. The data processing unit 12 can also receive the medicine application instruction sent by the external wireless receiving equipment and drive the micro medicine application pump 17 to apply medicine, so that detection personnel can correct the medicine application position and the medicine application amount according to the pH value and the temperature information transmitted in real time.
In the description herein, references to the description of "one embodiment," "an example," "a specific example" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The preferred embodiments of the invention disclosed above are intended to be illustrative only. The preferred embodiments are not intended to be exhaustive or to limit the invention to the precise embodiments disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best utilize the invention. The invention is limited only by the claims and their full scope and equivalents.
Claims (8)
1. The intelligent capsule for micro gastrointestinal examination, pH value positioning and targeted quantitative drug delivery comprises a capsule body, and is characterized in that the capsule body consists of a functional cabin, an operation cabin and a drug cabin, wherein,
the functional cabin is used for acquiring images, temperature and pH information in the intestines and the stomach, wirelessly transmitting the information to the in-vitro wireless receiving equipment and receiving an operation instruction transmitted by the in-vitro wireless receiving equipment, transmitting an application instruction to the operating cabin, and generating electric energy by utilizing deformation to maintain the normal operation of the system;
the operation cabin is used for receiving the medicine application instruction transmitted by the functional cabin and quantitatively releasing the medicine;
a drug compartment to store therapeutic drugs.
2. The intelligent capsule for micro gastrointestinal examination, pH positioning and targeted quantitative drug delivery according to claim 1, wherein the capsule body is of an integrated structure, and the functional compartment, the operation compartment and the drug compartment are separated by an isolation layer in the capsule body.
3. The intelligent capsule for micro gastrointestinal examination, pH positioning and targeted quantitative drug delivery according to claim 1, wherein the capsule body is of a detachable structure, the functional compartment is detachably connected with the operation compartment, and the operation compartment is detachably connected with the drug compartment.
4. The intelligent capsule for micro gastrointestinal examination, pH positioning and targeted quantitative drug delivery according to claim 2 or 3, wherein an image shooting mechanism, a data processing unit, a power supply unit, a power management unit and a wireless signal transceiving unit are fixed in the functional cabin, a parameter measuring sensor and a deformation power generation mechanism are fixed outside the functional cabin, a quantitative drug delivery mechanism is fixed in the operation cabin, therapeutic drugs are hermetically stored in the drug cabin, the image shooting mechanism, the power supply unit, the power management unit, the wireless signal transceiving unit, the parameter measuring sensor and the quantitative drug delivery mechanism are all connected with the data processing unit, and the deformation power generation mechanism is connected with the power management unit.
5. The micro intelligent capsule for gastrointestinal examination, pH positioning and targeted quantitative drug delivery according to claim 4, wherein the image capturing mechanism comprises a light emitting diode, a lens and a CMOS sensor, the light emitting diode is fixed at the periphery of the lens, the lens is fixed in front of the CMOS sensor, and the light emitting diode and the CMOS sensor are both connected with the data processing unit.
6. The micro intelligent capsule for gastrointestinal examination, pH positioning and targeted quantitative drug delivery according to claim 4, wherein the parameter measuring sensor comprises a patch type temperature sensor and a patch type pH sensor, the temperature sensor and the pH sensor are arranged above the functional cabin, the deformation power generation mechanism is a piezoelectric film sensor, the piezoelectric film sensor is arranged below the functional cabin, the wireless signal transceiver unit comprises a wireless transceiver module and a coil type antenna, and the wireless transceiver module and the antenna are fixed at the bottom in the cavity of the functional cabin.
7. The intelligent capsule for micro gastrointestinal examination, pH positioning and targeted quantitative drug delivery according to claim 4, wherein the quantitative drug delivery mechanism comprises a micro drug delivery pump and a flow meter, the micro drug delivery pump and the flow meter are fixed in the operation cabin, a drug inlet pipe of the micro drug delivery pump is inserted into the drug cabin, the flow meter is fixed on the drug inlet pipe, the micro drug delivery pump is connected with the data processing unit, and a drug outlet pipe of the micro drug delivery pump is fixed on the cabin surface of the operation cabin and is flush with the cabin surface.
8. The micro intelligent capsule for gastrointestinal examination, pH positioning and targeted quantitative drug delivery according to claim 7, wherein the drug compartment is divided into a plurality of drug cavities by criss-cross grids, the number of the micro drug delivery pumps is the same as that of the drug cavities, and the drug inlet pipes of the micro drug delivery pumps are inserted into the drug cavities.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011373912.5A CN112450857A (en) | 2020-11-30 | 2020-11-30 | Micro intelligent capsule for gastrointestinal examination, pH value positioning and targeted quantitative drug delivery |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011373912.5A CN112450857A (en) | 2020-11-30 | 2020-11-30 | Micro intelligent capsule for gastrointestinal examination, pH value positioning and targeted quantitative drug delivery |
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| CN112450857A true CN112450857A (en) | 2021-03-09 |
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| CN202011373912.5A Pending CN112450857A (en) | 2020-11-30 | 2020-11-30 | Micro intelligent capsule for gastrointestinal examination, pH value positioning and targeted quantitative drug delivery |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020198470A1 (en) * | 2001-06-26 | 2002-12-26 | Imran Mir A. | Capsule and method for treating or diagnosing the intestinal tract |
| US20050148847A1 (en) * | 2003-09-29 | 2005-07-07 | Olympus Corporation | Capsule medication administration system, medication administration method using capsule medication administration system, control method for capsule medication administration system |
| US20050192478A1 (en) * | 2004-02-27 | 2005-09-01 | Williams James P. | System and method for endoscopic optical constrast imaging using an endo-robot |
| JP2006061399A (en) * | 2004-08-26 | 2006-03-09 | Hitachi Ltd | Examination capsule and examination system |
| US20130204085A1 (en) * | 2012-02-07 | 2013-08-08 | Ian J. Alexander | System and method for a magnetic endoscope |
-
2020
- 2020-11-30 CN CN202011373912.5A patent/CN112450857A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020198470A1 (en) * | 2001-06-26 | 2002-12-26 | Imran Mir A. | Capsule and method for treating or diagnosing the intestinal tract |
| US20050148847A1 (en) * | 2003-09-29 | 2005-07-07 | Olympus Corporation | Capsule medication administration system, medication administration method using capsule medication administration system, control method for capsule medication administration system |
| US20050192478A1 (en) * | 2004-02-27 | 2005-09-01 | Williams James P. | System and method for endoscopic optical constrast imaging using an endo-robot |
| JP2006061399A (en) * | 2004-08-26 | 2006-03-09 | Hitachi Ltd | Examination capsule and examination system |
| US20130204085A1 (en) * | 2012-02-07 | 2013-08-08 | Ian J. Alexander | System and method for a magnetic endoscope |
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