CN112402451A - anti-HPV (human papilloma Virus) and HSV (herpes Simplex virus) medicine and preparation method thereof - Google Patents

Abstract

The invention discloses an anti-HPV and anti-HSV medicament, which comprises 0.1-2 parts of amino polysaccharide quaternary ammonium salt, 0.2-5 parts of algal polysaccharide, 0.3-1.5 parts of sea salt and 0.3-10 parts of copper phytate according to parts by weight. The anti-HPV and anti-HSV medicament and the preparation method thereof are safe and reliable, can realize effective inhibition of HPV and HSV virus, and are convenient to operate.

Description

anti-HPV (human papilloma Virus) and HSV (herpes Simplex virus) medicine and preparation method thereof

Technical Field

The invention relates to the technical field of HPV and HSV treatment, in particular to an anti-HPV and anti-HSV medicament and a preparation method thereof.

Background

Cervical cancer accounts for the second place of female gynecological malignant tumors, and is an important disease threatening female health, the number of people dying from cervical cancer in China is nearly 5 thousands every year, the research on the etiology of cervical cancer is always paid attention to scholars at home and abroad, and the research finds that the key of causing cervical cancer is HPV infection. HPV belongs to the genus papillomavirus of the family papillomaviraceae and is a spherical, double-stranded circular DNA virus. HPV infects humans primarily by direct or indirect contact with contaminated articles or by sexual transmission. Currently, there is no clinically effective treatment for HPV viruses in cervical mucosal cells. If the patient can quickly turn negative when the HPV is positive, the risk of the patient turning from HPV positive to cervical cancer is undoubtedly reduced to a great extent.

HSV, also known as herpes simplex virus, is very common to people infected with HSV, has an infection rate of 80-90 percent and is the virus which is most likely to invade human bodies. HSV enters the body through mucous membranes of oral cavity, respiratory tract and reproductive tract and is spread by sexual contact and direct close contact. After a host is infected, latent infection is usually established in nerve cells, asymptomatic detoxification can occur after activation, and a transmission chain is maintained in people, so that the circulation is repeated. Currently, therapies are available that help the host immune system to fight herpes viruses itself. The vast majority of therapeutic approaches focus on: fusion of the virion envelope with the host cell plasma membrane is prevented by negatively affecting host cell membrane receptors, or by interfering with glycosylation of viral proteins required for fusion, and by reducing viral replication in the host cell nucleus.

Disclosure of Invention

The invention aims to provide an anti-HPV and anti-HSV medicament and a preparation method thereof, which are safe and reliable, can realize effective inhibition of HPV and HSV virus and are convenient to operate.

In order to achieve the purpose, the invention provides an anti-HPV and anti-HSV medicament, which comprises 0.1 to 2 parts of amino polysaccharide quaternary ammonium salt, 0.2 to 5 parts of algal polysaccharide, 0.3 to 1.5 parts of sea salt and 0.3 to 10 parts of copper phytate according to parts by weight.

Preferably, the components and the proportion by weight comprise 0.2 part of amino polysaccharide quaternary ammonium salt, 4.7 parts of algal polysaccharide, 1.4 parts of sea salt and 0.5 part of copper phytate.

Preferably, the components and the proportion by weight comprise 1.8 parts of amino polysaccharide quaternary ammonium salt, 2.7 parts of algal polysaccharide, 0.6 part of sea salt and 8.7 parts of copper phytate.

Preferably, the components and the proportion by weight comprise 1.3 parts of amino polysaccharide quaternary ammonium salt, 0.4 part of algal polysaccharide, 0.5 part of sea salt and 5.4 parts of copper phytate.

Preferably, the components and the proportion by weight comprise 0.7 part of amino polysaccharide quaternary ammonium salt, 3.2 parts of algal polysaccharide, 0.9 part of sea salt and 3.9 parts of copper phytate.

A preparation method of anti-HPV and anti-HSV drugs, a preparation method of gel-state drugs, comprises the following steps:

s1, mixing carbomer with water, and heating to dissolve carbomer to obtain a solution a for later use; wherein, 5-20 parts of carbomer, and water and carbomer are added in equal amount;

s2, mixing and dissolving copper phytate and water in equal proportion, standing stably, adding sea salt and water, fully dissolving and stirring, and standing for 4-6h to obtain a solution b;

s3, respectively dissolving seaweed polysaccharide and amino polysaccharide quaternary ammonium salt and then mixing to obtain a solution c;

and S4, sequentially adding the solution a, the solution b and the solution c into water, uniformly stirring, and adjusting the pH value to obtain the water-based paint.

A preparation method of anti-HPV and anti-HSV drugs and a preparation method of liquid drugs comprise the following steps:

s1, adding water to dissolve copper phytate, adding sea salt in proportion, uniformly stirring, and standing for 4-6h to obtain a solution a;

s2, respectively dissolving seaweed polysaccharide and amino polysaccharide quaternary ammonium salt and then mixing to obtain a solution b;

and S3, sequentially adding the solution a and the solution b into water, and uniformly stirring to obtain the water-based paint.

Therefore, the anti-HPV and anti-HSV medicament and the preparation method thereof are safe and reliable, can realize effective inhibition of HPV and HSV virus, and are convenient to operate.

The amino polysaccharide quaternary ammonium salt has broad-spectrum bactericidal property, can kill most of bacteria, mold, spores and other microorganisms which are contacted with the amino polysaccharide quaternary ammonium salt, and has strong bactericidal effect on drug-resistant pathogenic bacteria, escherichia coli, pseudomonas aeruginosa, candida albicans, chlamydia trachomatis, gonococcus and the like.

The algal polysaccharide can interfere the process of HPV (human papilloma Virus) absorption and cell infiltration, and can form a non-infectious polysaccharide virus compound for blocking HPV transmission; can also inhibit HPV replication; the immune function of the organism is improved by activating the immunity of the organism or improving the biological response function of the organism; enhancing the functions of T cells, B cells and macrophages.

The sea salt contains various other trace elements, and has antibacterial, antiviral (Ag and Zn ion effects), antiallergic (Mn ion effect), and antiinflammatory (Cu ion effect). Meanwhile, Na ions perform composite crosslinking on the composite copper phytate, and the effect of adjusting the association of the combined frames is achieved.

Sodium ions in the sea salt can be fully introduced into the compound phytic acid ketone to form a new compound component, has the HSV inhibition effect, can directly kill viruses, block the replication and transmission of the viruses and inhibit the cytopathy induced by virus cells. And the composite copper phytate composite compound has the effects of resisting HIV, inhibiting reverse transcriptase, integrase, protease, virus and cell CD4 receptor, inhibiting glycosylation and influencing HIV assembly and release.

The technical solution of the present invention is further described in detail by the following examples.

Detailed Description

The embodiments of the present invention will be further explained below.

The medicine for resisting HPV and HSV consists of amino polysaccharide quaternary ammonium salt 0.1-2 weight portions, algal polysaccharide 0.2-5 weight portions, sea salt 0.3-1.5 weight portions and copper phytate 0.3-10 weight portions.

A preparation method of anti-HPV and anti-HSV drugs, a preparation method of 1000mL gel-state drugs, comprises the following steps:

s1, mixing carbomer with water, and heating to dissolve carbomer to obtain a solution a for later use; wherein, 5-20 parts of carbomer, and water and carbomer are added in equal amount;

s2, mixing and dissolving copper phytate and water in equal proportion, standing stably, adding sea salt and water, fully dissolving and stirring, and standing for 4-6h to obtain a solution b;

s3, respectively dissolving seaweed polysaccharide and amino polysaccharide quaternary ammonium salt and then mixing to obtain a solution c;

and S4, sequentially adding the solution a, the solution b and the solution c into 750mL of water, uniformly stirring, and adjusting the pH value to obtain the water-soluble organic fertilizer.

A preparation method of anti-HPV and anti-HSV drugs, a preparation method of 1000mL liquid drugs, comprises the following steps:

s1, adding water to dissolve copper phytate, adding sea salt in proportion, uniformly stirring, and standing for 4-6h to obtain a solution a;

s2, respectively dissolving seaweed polysaccharide and amino polysaccharide quaternary ammonium salt and then mixing to obtain a solution b;

and S3, sequentially adding the solution a and the solution b into 800mL of water, and uniformly stirring to obtain the water-based paint.

Example one

The medicine for resisting HPV and HSV consists of amino polysaccharide quaternary ammonium salt 0.2 weight portions, algal polysaccharide 4.7 weight portions, sea salt 1.4 weight portions and copper phytate 0.5 weight portions.

Example two

The medicine for resisting HPV and HSV consists of amino polysaccharide quaternary ammonium salt 1.8 weight portions, algal polysaccharide 2.7 weight portions, sea salt 0.6 weight portions and copper phytate 8.7 weight portions.

EXAMPLE III

The medicine for resisting HPV and HSV consists of amino polysaccharide quaternary ammonium salt 1.3 weight portions, algal polysaccharide 0.4 weight portions, sea salt 0.5 weight portions and copper phytate 5.4 weight portions.

Example four

The medicine for resisting HPV and HSV consists of amino polysaccharide quaternary ammonium salt 0.7 weight portions, algal polysaccharide 3.2 weight portions, sea salt 0.9 weight portions and copper phytate 3.9 weight portions.

Comparative example 1

The medicine for resisting HPV and HSV consists of amino polysaccharide quaternary ammonium salt 0.7 weight portions, algal polysaccharide 3.2 weight portions and sea salt 0.9 weight portions. Compared with example four, no copper phytate was added.

Comparative example No. two

The medicine for resisting HPV and HSV consists of amino polysaccharide quaternary ammonium salt 0.7 weight portions, algal polysaccharide 3.2 weight portions, sea salt 0.9 weight portions and copper phytate 0.5 weight portions. Compared with the four examples, the dosage of the copper phytate is low.

Test of

(1) Testing for HPV

The outpatient confirmed low-risk 99 HPV patients were selected and randomly divided into 3 groups including test group one, test group two and test group three, and the gel-state drugs prepared in example four, comparative example one and comparative example two were used respectively, and after 1 month of use, the patient remission rate of test group one was 96%, the patient remission rate of test group two was 10% and the patient remission rate of test group three was 50%.

(2) Testing for HSV

99 HSV patients confirmed in outpatient diagnosis are selected and randomly divided into 3 groups, including a test group I, a test group II and a test group III, and gel-state medicaments prepared in the example IV, the comparative example I and the comparative example II are respectively used, after 1 week of use, the patient remission rate of the test group I is 99%, the patient remission rate of the test group II is 15%, and the patient remission rate of the test group III is 60%.

Therefore, the anti-HPV and anti-HSV medicament and the preparation method thereof are safe and reliable, can realize effective inhibition of HPV and HSV virus, and are convenient to operate.

The foregoing is only a preferred embodiment of the present invention, and it should be noted that modifications can be made by those skilled in the art without departing from the principle of the present invention, and these modifications should also be construed as the protection scope of the present invention.

Claims (7)

1. An anti-HPV and anti-HSV drug, which is characterized in that: the components and the proportion by weight comprise 0.1 to 2 portions of amino polysaccharide quaternary ammonium salt, 0.2 to 5 portions of algal polysaccharide, 0.3 to 1.5 portions of sea salt and 0.3 to 10 portions of copper phytate.

2. An anti-HPV, HSV agent according to claim 1, wherein: the components and the proportion by weight comprise 0.2 part of amino polysaccharide quaternary ammonium salt, 4.7 parts of algal polysaccharide, 1.4 parts of sea salt and 0.5 part of copper phytate.

3. An anti-HPV, HSV agent according to claim 1, wherein: the components and the proportion by weight comprise 1.8 parts of amino polysaccharide quaternary ammonium salt, 2.7 parts of algal polysaccharide, 0.6 part of sea salt and 8.7 parts of copper phytate.

4. An anti-HPV, HSV agent according to claim 1, wherein: the components and the proportion by weight comprise 1.3 parts of amino polysaccharide quaternary ammonium salt, 0.4 part of algal polysaccharide, 0.5 part of sea salt and 5.4 parts of copper phytate.

5. An anti-HPV, HSV agent according to claim 1, wherein: the components and the proportion by weight comprise 0.7 part of amino polysaccharide quaternary ammonium salt, 3.2 parts of algal polysaccharide, 0.9 part of sea salt and 3.9 parts of copper phytate.

6. The preparation method of the anti-HPV and anti-HSV drug is characterized in that the preparation method of the gel-state drug comprises the following steps:

s1, mixing carbomer with water, and heating to dissolve carbomer to obtain a solution a for later use; wherein, 5-20 parts of carbomer, and water and carbomer are added in equal amount;

s2, mixing and dissolving copper phytate and water in equal proportion, standing stably, adding sea salt and water, fully dissolving and stirring, and standing for 4-6h to obtain a solution b;

s3, respectively dissolving seaweed polysaccharide and amino polysaccharide quaternary ammonium salt and then mixing to obtain a solution c;

and S4, sequentially adding the solution a, the solution b and the solution c into water, uniformly stirring, and adjusting the pH value to obtain the water-based paint.

7. The preparation method of the anti-HPV and anti-HSV drug is characterized in that the preparation method of the liquid drug comprises the following steps:

s1, adding water to dissolve copper phytate, adding sea salt in proportion, uniformly stirring, and standing for 4-6h to obtain a solution a;

s2, respectively dissolving seaweed polysaccharide and amino polysaccharide quaternary ammonium salt and then mixing to obtain a solution b;

and S3, sequentially adding the solution a and the solution b into water, and uniformly stirring to obtain the water-based paint.