CN112378705A - Sampling device and sample analyzer - Google Patents
Sampling device and sample analyzer Download PDFInfo
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- CN112378705A CN112378705A CN202011170607.6A CN202011170607A CN112378705A CN 112378705 A CN112378705 A CN 112378705A CN 202011170607 A CN202011170607 A CN 202011170607A CN 112378705 A CN112378705 A CN 112378705A
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- 238000005070 sampling Methods 0.000 title claims abstract description 80
- 238000004140 cleaning Methods 0.000 claims description 58
- 239000008280 blood Substances 0.000 claims description 36
- 210000004369 blood Anatomy 0.000 claims description 36
- 238000009434 installation Methods 0.000 claims description 10
- 230000007704 transition Effects 0.000 claims description 9
- 238000005520 cutting process Methods 0.000 claims description 5
- 210000001503 joint Anatomy 0.000 claims 1
- 230000005540 biological transmission Effects 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 description 13
- 239000007788 liquid Substances 0.000 description 10
- 238000000034 method Methods 0.000 description 9
- 230000033001 locomotion Effects 0.000 description 8
- 238000001514 detection method Methods 0.000 description 7
- 230000000903 blocking effect Effects 0.000 description 6
- 238000010241 blood sampling Methods 0.000 description 6
- 239000011521 glass Substances 0.000 description 6
- 230000009471 action Effects 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 230000008569 process Effects 0.000 description 4
- 230000005622 photoelectricity Effects 0.000 description 3
- 238000009971 piece dyeing Methods 0.000 description 3
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 239000004593 Epoxy Substances 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
- B08B3/041—Cleaning travelling work
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
- B08B3/08—Cleaning involving contact with liquid the liquid having chemical or dissolving effect
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hydrology & Water Resources (AREA)
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- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention discloses a sampling device and a sample analyzer, wherein the sampling device comprises a puncture assembly and a sample dripping assembly, the puncture assembly comprises a puncture needle with a puncture needle hole, and the sample dripping assembly comprises a sample dripping needle which can penetrate through the puncture needle hole of the puncture needle. The invention can reduce the transportation and transmission of the samples and save the use amount of the samples.
Description
Technical Field
The invention relates to the technical field of medical detection instruments, in particular to a sampling device and a sample analyzer.
Background
The sampling device is an important component of medical detection instruments such as a push piece dyeing instrument and the like. Taking the slide-push staining apparatus as an example, it needs to transfer the blood sample from the vacuum blood collection tube to the slide glass through the sampling device, so as to facilitate the subsequent detection and observation.
At present, a sampling device of a push piece dyeing instrument generally comprises a puncture needle, a sample dripping needle and the like, when the sampling device works, the puncture needle is utilized to puncture a vacuum rubber plug of a blood sampling tube and suck a blood sample from the vacuum blood sampling tube under the action of a blood sucking injector, then the blood sample in the puncture needle is transferred into the sample dripping needle under the combined action of the injector, a pipeline and a valve, and the sample is dripped out of the sample dripping needle onto a glass slide so as to complete the subsequent operations of pushing piece, dyeing and the like; this sampling method has a problem that the blood sample moves along a long path, resulting in a large amount of blood.
Therefore, it is desirable to provide a new sampling device.
Disclosure of Invention
The embodiment of the invention provides a sampling device and a sample analyzer, aiming at reducing the transportation and transmission of samples and saving the use amount of the samples.
In one aspect, an embodiment of the present invention provides a sampling apparatus, where the sampling apparatus includes: the puncture assembly comprises a puncture needle with a puncture needle hole; the sample dropping component comprises a sample dropping needle which can penetrate through the puncture needle hole of the puncture needle.
According to one aspect of the embodiment of the invention, the coaxiality tolerance of the needle head end and the needle tail end of the sample dropping needle is not more than 0.1 mm;
preferably, the needle head end is provided with a spherical end surface, a sample dropping needle hole of the sample dropping needle penetrates through the needle head end, and the hole wall of the sample dropping needle hole is in arc transition connection with the spherical end surface;
preferably, the roughness of the inner wall and the outer wall of the needle head end is not more than 0.1 μm.
According to one aspect of an embodiment of the present invention, the puncture needle includes a needle tip having a beveled edge, the beveled edge being inclined at an angle of 25 ° to 35 ° with respect to the direction of extension of the puncture needle;
preferably, the beveling cutting edge is in arc transition connection with both the inner wall and the outer wall of the needle tip, and the radius of the transition arc is 0.02-0.05 mm;
preferably, the roughness of the inner wall, the outer wall of the needle tip and the bevel of the beveling edge is not more than 0.4 μm.
According to one aspect of the embodiment of the invention, the sample dropping device further comprises a base, the base comprises a main body part, a first support and a second support, the first support and the second support are movably connected to the main body part, the puncture assembly is connected to the first support, the sample dropping assembly is connected to the second support, the puncture needle and the sample dropping needle both extend along a first direction, and the second support can drive the sample dropping needle to penetrate through a puncture needle hole of the puncture needle.
According to one aspect of the embodiment of the present invention, the sample dropping needle and the puncture needle are coaxially disposed, and the puncture needle is fitted over the sample dropping needle.
According to one aspect of the embodiment of the invention, the sample dropping component comprises a sample dropping connecting plate and a mounting part, the mounting part enables a sample dropping needle to extend on the second support along a first direction, the sample dropping connecting plate is connected with the second support, the mounting part comprises a fixing sleeve, an elastic piece and a mounting block with a mounting groove, the sample dropping connecting plate is connected with the second support, the mounting block is connected with the sample dropping connecting plate, a first through hole for the sample dropping needle to penetrate through is formed in the sample dropping connecting plate and the mounting block, the fixing sleeve and the elastic piece are arranged in the mounting groove, the needle tail end of the sample dropping needle penetrates through the fixing sleeve and is fixedly connected with the fixing sleeve, and the elastic piece is sleeved outside the sample dropping needle and is arranged between the fixing.
According to an aspect of the embodiment of the present invention, the guide assembly further includes a guide assembly, the guide assembly includes a guide rail disposed on the main body portion, and a first slider and a second slider slidably coupled to the guide rail, the guide rail extends along a first direction, the first slider is fixedly coupled to the first bracket, and the second slider is fixedly coupled to the second bracket.
According to one aspect of the embodiment of the invention, the blood sampling device further comprises a driving assembly, wherein the driving assembly comprises a first driver and a second driver, the first driver drives the first bracket to move along the first direction to enable the puncture needle to puncture the blood sampling tube, and the second driver drives the second bracket to move along the first direction to enable the dropping needle to penetrate through the puncture hole of the puncture needle and enter the blood sampling tube to complete sampling.
According to an aspect of the embodiment of the present invention, the first driver and the second driver are both screw motors, the first driver includes a first body and a first screw nut disposed in the first body, the second driver includes a second body and a second screw nut disposed in the second body, the driving assembly further includes a screw rod extending along the first direction, the screw rod is fixedly connected to the main body portion, the first screw nut and the second screw nut are both in threaded connection with the screw rod, the first bracket is connected to the first body, and the second bracket is connected to the second body.
According to an aspect of the embodiment of the invention, the puncture assembly further comprises a cleaning swab, a cleaning channel extending along the first direction is arranged on the cleaning swab, the puncture assembly further comprises a puncture connecting plate, a second through hole allowing a sample dropping needle to penetrate through is arranged on the puncture connecting plate, the puncture connecting plate is connected with the first bracket, the cleaning swab is connected to the puncture connecting plate, the puncture needle is connected to the cleaning swab, the second through hole is communicated with the cleaning channel of the cleaning swab, and a puncture needle hole of the puncture needle is communicated with the cleaning channel.
According to one aspect of the embodiment of the invention, the cleaning channel of the cleaning swab comprises a guide section, a cleaning section and a mounting section which are sequentially arranged, the ratio of the inner diameter of the guide section to the outer diameter of the sample dropping needle is 1.05-1.12, and the tail end of the puncture needle is in matched connection with the mounting section.
In another aspect, an embodiment of the present invention provides a sample analyzer, including a sampling device as described in any of the previous embodiments.
According to the sampling device and the sample analyzer provided by the embodiment of the invention, the puncture needle can puncture the test tube cap of the blood collection tube, the sample dripping needle can penetrate through the puncture hole of the puncture needle, during sampling, the puncture needle punctures the test tube cap of the blood collection tube, the sample dripping needle penetrates through the puncture hole of the puncture needle and enters the blood collection tube to complete sampling, and then the sample dripping needle moves out of the blood collection tube and drips a sample onto the glass slide. In addition, the sample dropping needle does not need to have a puncture function during sampling, and does not have friction contact with a test tube cap of the blood collection tube, so that the structure of the sample dropping needle is not limited, the sample dropping mode is not limited, and the service life of the sample dropping needle is longer.
Drawings
Other features, objects and advantages of the invention will become apparent from the following detailed description of non-limiting embodiments thereof, when read in conjunction with the accompanying drawings, in which like reference characters designate the same or similar parts throughout the figures thereof, and which are not to scale.
Fig. 1 is a schematic structural diagram of a sampling apparatus according to an embodiment of the present invention;
fig. 2 is a partial schematic structural view of a puncture needle of a sampling device according to an embodiment of the present invention;
FIG. 3 is a schematic view of the installation of a sample dropping needle of the sampling device according to one embodiment of the present invention;
FIG. 4 is a schematic diagram of a cleaning swab of a sampling device according to an embodiment of the present invention;
fig. 5 illustrates a cross-sectional view of a cleaning swab of a sampling device according to an embodiment of the present invention.
Description of reference numerals:
11-a body portion;
20-a puncture assembly; 21-puncture needle; 211-beveling the cutting edge; 22-a puncture connecting plate;
30-a sample drop assembly; 31-a sample dropping needle; 32-a mounting portion; 321-fixing sleeves; 322-an elastic member; 323-mounting block; 33-a drop sample connection plate;
41-a guide rail;
50-a drive assembly; 51-a first driver; 52-a second driver; 53-lead screw;
61-first groove type photoelectricity; 62-a first baffle plate; 63-a second groove type photoelectric device; 64-second baffle.
70-washing the swab; 71-a purge channel; 711-a guide section; 712-a cleaning section; 713-a mounting segment; 72-a liquid inlet channel; 73-liquid outlet channel.
Detailed Description
Features and exemplary embodiments of various aspects of the present invention will be described in detail below, and in order to make objects, technical solutions and advantages of the present invention more apparent, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not to be construed as limiting the invention. It will be apparent to one skilled in the art that the present invention may be practiced without some of these specific details. The following description of the embodiments is merely intended to provide a better understanding of the present invention by illustrating examples of the present invention.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.
The embodiment of the invention provides a sampling device which can be used for medical detection instruments such as a push piece dyeing instrument and the like.
Referring to fig. 1, fig. 1 is a schematic structural diagram of a sampling device according to an embodiment of the present invention.
The sampling device provided by the embodiment of the invention comprises a puncture assembly 20 and a dropping sample assembly 30. The puncture assembly 20 includes a puncture needle 21 having a puncture needle hole; the drip assembly 30 includes a drip needle 31 that can pass through the puncture needle hole of the puncture needle 21.
According to the sampling device provided by the embodiment of the invention, the puncture needle 21 can puncture a test tube cap of a blood collection tube, and the sample dropping needle 31 can penetrate through the puncture hole of the puncture needle 21, during sampling, the puncture needle 21 can puncture the test tube cap of the blood collection tube, the puncture needle 21 can stay in the test tube cap after puncturing the blood collection tube, then the sample dropping needle 31 penetrates through the puncture hole of the puncture needle 21 and enters the blood collection tube to complete sampling, and then the sample dropping needle 31 is moved out of the blood collection tube and drops a sample onto a glass slide. By adopting the sampling mode, the sample can be directly collected and dripped by the dripping needle 31 without secondary conveying of the sample through a pipeline, so that the sample consumption can be saved.
Meanwhile, the sample dripping needle 31 does not need to have a puncture function during sampling, and does not have friction contact with a test tube cap of a blood collection tube, so that the structure of the sample dripping needle 31 is not limited, the sample dripping mode is not limited, and the service life of the sample dripping needle 31 is long.
It should be noted that, the specific usage of the sampling device provided in the embodiment of the present invention is not limited to "the puncture needle 21 stays in the test tube cap after puncturing the blood collection tube, and the sample dropping needle 31 passes through the puncture hole of the puncture needle 21 and enters the blood collection tube to complete sampling", as an alternative embodiment, during sampling, the puncture needle 21 is first used to puncture the test tube cap of the blood collection tube, then the puncture needle 21 is moved out of the blood collection tube and moved to one side of the blood collection tube, and then the sample dropping needle 31 is moved to above the blood collection tube and descends into the blood collection tube to complete sampling, which is also within the protection scope of the present invention. It can be understood that, the puncture needle 21 is removed after puncturing the blood collection tube, and a puncture crevasse is left on the test tube cap of the blood collection tube, so that the sample dropping needle 31 can enter for a second time.
Referring to fig. 2 and fig. 3 together, fig. 2 is a schematic partial structure diagram of a puncture needle of a sampling device according to an embodiment of the present invention; fig. 3 is a schematic view illustrating the installation of a dropping needle of a sampling device according to an embodiment of the present invention.
It is understood that the puncture needle 21 includes a needle tip, and in order to avoid rubber debris or an excessive puncture tear from being generated when puncturing a test tube cap of a blood collection tube, in some alternative embodiments, the needle tip may have a chamfered cutting edge 211, and the angle θ of inclination of the chamfered cutting edge 211 with respect to the extending direction of the puncture needle 21 may be 25 ° to 35 °. Alternatively, the angle θ of inclination of the beveling edge 211 with respect to the extending direction of the puncture needle 21 is 30 °.
As an alternative embodiment, the beveled edge 211 may be in arcuate transition with the inner and outer walls of the needle tip, and may be ground to reduce debris generated by the needle tip during penetration by the needle 21. Alternatively, the radius of the transition arc may be 0.02mm to 0.05 mm.
Alternatively, in order to facilitate the cleaning of the puncture needle 21, the roughness of the inner wall, the outer wall of the needle tip of the puncture needle 21 and the slope of the chamfered edge 211 may be each not more than 0.4 μm.
It is understood that the drip needle 31 can pass through the puncture needle hole of the puncture needle 21, and the outer diameter of the drip needle 31 is smaller than the inner diameter of the puncture needle 21.
It will be appreciated that the drip needle 31 has a needle end and a needle tail end. In order to enable the sample dropping needle 31 to smoothly pass through the puncture hole of the puncture needle 21 without collision, the present invention has a high requirement on the circular axial degree of the sample dropping needle 31. Optionally, the tolerance of the coaxiality of the needle end and the needle tail end of the sample dropping needle 31 is not more than 0.1 mm.
As an optional embodiment, the syringe needle end of dripping appearance needle 31 can have spherical terminal surface, and the needle head end is run through to the dripping appearance pinhole of dripping appearance needle 31, and the syringe needle end of dripping appearance needle 31 can also be opened has the U type groove of being convenient for drip appearance, and the pore wall of dripping the appearance pinhole can arc transitional coupling with the junction of spherical terminal surface, specifically can abrasive machining, can make dripping appearance needle 31 drip appearance more smooth and easy, makes things convenient for the washing of the syringe needle end of dripping appearance needle 31 simultaneously. Alternatively, the radius of the transition arc connecting the hole wall of the dripping pin hole and the spherical end surface can be 0.02mm to 0.05 mm.
Optionally, in order to facilitate the cleaning of the sample dropping needle 31, the roughness of the inner wall of the sample dropping needle 31, i.e. the wall of the sample dropping needle hole, is not more than 0.1 μm, the roughness of the outer wall of the needle end is not more than 0.1 μm, and the roughness of the outer wall of the other part of the sample dropping needle 31 is not more than 1.6 μm.
In some alternative embodiments, the sampling device provided in the embodiments of the present invention may further include a base, where the base may include the main body 11, a first bracket and a second bracket movably connected to the main body 11, the puncture assembly 20 is connected to the first bracket, the drip assembly 30 is connected to the second bracket, the puncture needle 21 and the drip needle 31 both extend along a first direction (Z direction in fig. 1), and the second bracket can drive the drip needle 31 to pass through the puncture needle hole of the puncture needle 21. Alternatively, the first direction may be a vertical direction.
According to the sampling device provided by the embodiment of the invention, during sampling, the puncture needle 21 can be driven by the first bracket to move so as to puncture the test tube cap of the blood collection tube, the puncture needle 21 can stay in the test tube cap after puncturing the blood collection tube, then the sample dropping needle 31 can be driven by the second bracket to pass through the puncture hole of the puncture needle 21 and enter the blood collection tube to complete sampling, and then the sample dropping needle 31 is moved out of the blood collection tube and drops the sample onto the glass slide.
In some alternative embodiments, the spike assembly 20 may be removably attached to the first holder and the drip assembly 30 may be removably attached to the second holder to facilitate transport and storage of the sampling device. Alternatively, the spike assembly 20 is bolted to the first rack and the drip assembly 30 is bolted to the second rack.
In some optional embodiments, the sample dropping assembly 30 may include a sample dropping connection plate 33 and a mounting portion 32 extending the sample dropping needle 31 along a first direction on the second support, the sample dropping connection plate 33 is connected to the second support, the mounting portion 32 may include a fixing sleeve 321, an elastic member 322 and a mounting block 323 having a mounting groove, the mounting block 323 is connected to the sample dropping connection plate 33, the sample dropping connection plate 33 and the mounting block 323 are both provided with a first through hole for the sample dropping needle 31 to pass through, the fixing sleeve 321 and the elastic member 322 are disposed in the mounting groove of the mounting block 323, a needle tail end of the sample dropping needle 31 penetrates through the fixing sleeve 321 and is fixedly connected to the fixing sleeve 321, and the elastic member 322 is sleeved outside the sample dropping needle 31 and is disposed between the fixing sleeve 321 and the mounting block 323.
On the one hand, can make the sample dropping needle 31 keep extending along the first direction at the removal in-process through installation department 32, guarantee that the sample dropping needle 31 can pass and not collide in the puncture needle hole of pjncture needle 21 smoothly, on the other hand, when the sample dropping needle 31 descends to its syringe needle end and other accessories such as slide glass looks butt, the elastic component 322 atress in the mounting groove can compress, can avoid the syringe needle end of sample dropping needle 31 and other accessories to take place the stereoplasm and contact, and then avoid damaging sample dropping needle 31, can prolong the life of sample dropping needle 31.
Optionally, one end of the fixing sleeve 321 may be provided with a ring-shaped slot, and one end of the elastic element 322 is disposed in the ring-shaped slot, so that the fixing is firm and optional.
Alternatively, the elastic member 322 may be a spring.
Alternatively, the sample dropping needle 31 and the fixing sleeve 321 may be bonded by a two-component adhesive containing epoxy, acrylic, etc.
In some optional embodiments, to facilitate the installation of the puncture needle 21, the puncture assembly 20 may further include a puncture connecting plate 22, the puncture connecting plate 22 is connected to the first bracket, a second through hole for allowing the drip needle 31 to pass through is formed in the puncture connecting plate 22, the puncture needle 21 may be connected to the puncture connecting plate 22, and the puncture needle hole is communicated with the second through hole.
In some alternative embodiments, to facilitate the structural design of the sampling device and save space, the needle 31 and the puncture needle 21 may be coaxially disposed, the first holder may be movable relative to the main body 11 in a first direction, and the second holder may be movable relative to the main body 11 in the first direction, so that the needle 31 can smoothly pass through the puncture hole of the puncture needle 21 without collision. In addition, in the sampling process, the puncture needle 21 can be always sleeved outside the sample dropping needle 31, which is beneficial to keeping the coaxial arrangement of the sample dropping needle 31 and the puncture needle 21.
In some optional embodiments, the sampling device provided in the embodiments of the present invention may further include a driving assembly 50 for driving the first bracket and the second bracket to move relative to the main body 11, so as to implement automatic puncturing and sampling. As an alternative embodiment, the driving assembly 50 may include a first driver 51 and a second driver 52, the first driver 51 may drive the first support to move in a first direction to make the puncture needle 21 puncture the blood collection tube, and the second driver 52 may drive the second support to move in the first direction to make the dropping needle 31 pass through the puncture hole of the puncture needle 21 and enter the blood collection tube to complete the sampling.
The first driver 51 and the second driver 52 are various, and in order to enable the sample dropping needle 31 to smoothly pass through the puncture needle hole of the puncture needle 21 without collision, in some alternative embodiments, the first driver 51 and the second driver 52 may both be screw motors, the first driver 51 includes a first body and a first screw nut disposed in the first body, the second driver 52 includes a second body and a second screw nut disposed in the second body, the driving assembly 50 further includes a screw 53, the screw 53 extends along a first direction and is fixedly connected to the main body 11, the first screw nut of the first driver 51 and the second screw nut of the second driver 52 are both in threaded connection with the screw 53, the first bracket is connected to the first body, and the second bracket is connected to the second body.
When the first driver 51 is started, the first lead screw nut and the lead screw 53 are relatively rotated, and because the lead screw 53 is fixed, the first lead screw nut moves along the extending direction of the lead screw 53 while rotating around the lead screw 53, and drives the first body to move along the first direction, and the first body drives the first bracket and the puncture assembly 20 to move along the first direction, so that puncture motion is realized; similarly, when the second driver 52 is started, the second body drives the second support and the sample dropping assembly 30 to move along the first direction, so as to realize the sampling movement.
The driving mode that two screw motors share one screw 53 is adopted, so that the first driver 51 and the second driver 52 can be ensured to be driven independently, the driving directions of the first driver 51 and the second driver 52 can be ensured to be consistent, the consistency of the puncture motion of the puncture needle 21 and the sampling motion direction of the sample dropping needle 31 is realized, and the sample dropping needle 31 can smoothly pass through the puncture needle hole of the puncture needle 21 without collision.
It will be appreciated that the first actuator 51 and the second actuator 52 are spaced apart in the first direction, which is the direction of extension of the lead screw 53, and that since the length of the drip needle 31 is generally longer than the puncture needle 21, the second actuator 52 is located above the first actuator 51 to ensure smooth operation of the sampling device.
Of course, the specific structure of the first driver 51 and the second driver 52 is not limited to this, and two completely independent drivers such as linear motors or air cylinders may be used to drive the first support and the second support, and the invention is also within the protection scope of the present invention.
In some optional embodiments, the sampling device provided in the embodiments of the present invention further includes a reset detection assembly, where the reset detection assembly includes a first groove-shaped photo-electric 61 and a first blocking sheet 62 used in pair, and a second groove-shaped photo-electric 63 and a second blocking sheet 64 used in pair; one of the first groove-shaped photoelectric cell 61 and the first blocking piece 62 may be disposed on the main body 11, and the other may be disposed on the first bracket or the first body of the first driver 51, the first driver 51 has a first initial position, and when the first driver 51 is located at the first initial position, the first blocking piece 62 blocks and triggers the first groove-shaped photoelectric cell 61; one of the second groove-shaped photo-electricity 63 and the second shutter 64 is disposed on the main body 11, the other is disposed on the second frame or the second body of the second driver 52, the second driver 52 has a second initial position, and when the second driver 52 is located at the second initial position, the second shutter 64 shutters and triggers the second groove-shaped photo-electricity 63.
Alternatively, the first groove-shaped photo 61 and the second groove-shaped photo 63 are disposed on the main body 11, the first blocking piece 62 is disposed on the first body of the first driver 51, and the second blocking piece 64 is disposed on the second body of the second driver 52.
During sampling, the moving distance of the puncture needle 21 and the sample dripping needle 31 can be set through the step pitch of the controller and the screw motor, so that puncture and sampling are realized, after sampling is completed by the sampling device once, the first driver 51 can be accurately reset to a first initial position by using the detection device, and the second driver 52 can be accurately reset to a second initial position, so that the superposition of motion deviation during each sampling can be avoided.
In some optional embodiments, the sampling device provided in the embodiments of the present invention may further include a guide assembly, where the guide assembly may include a guide rail 41 disposed on the main body portion 11, and a first slider and a second slider slidably connected to the guide rail 41, the guide rail 41 extends along a first direction, the first slider is fixedly connected to the first bracket, and the second slider is fixedly connected to the second bracket; when the first driver 51 drives the first support to move along the first direction, the first slider slides along the guide rail 41, and when the second driver 52 drives the second support to move along the first direction, the second slider slides along the guide rail 41, and the guide assembly can guide the movement of the first support and the second support.
It is understood that the first bracket, the puncturing connecting plate 22 and the first slider can be fixedly connected as a whole or detachably connected; the second bracket, the dripping sample connecting plate 33 and the second sliding block can be fixedly connected into a whole and can also be detachably connected.
Referring to fig. 4 and 5, fig. 4 is a schematic structural diagram illustrating a cleaning swab of a sampling device according to an embodiment of the present invention; fig. 5 illustrates a cross-sectional view of a cleaning swab of a sampling device according to an embodiment of the present invention.
Optionally, in order to facilitate the cleaning of the puncture needle 21 and the sample dropping needle 31, the sampling apparatus provided by the embodiment of the present invention may further include a cleaning swab 70, a cleaning channel 71 extending along the first direction is disposed on the cleaning swab 70, the cleaning swab 70 is connected below the puncture connecting plate 22, the puncture needle 21 is connected below the cleaning swab 70, the second through hole on the puncture connecting plate 22 is communicated with the cleaning channel 71 of the cleaning swab 70, and the puncture needle hole of the puncture needle 21 is communicated with the cleaning channel 71.
During sampling, the sample dripping needle 31 sequentially penetrates through the second through hole, the cleaning channel 71 and the puncture needle hole of the puncture needle 21 to enter the blood sampling tube; after the sampling device finishes sampling, cleaning liquid can be input into the cleaning channel 71 of the cleaning swab 70, so that the inner wall of the puncture needle 21 and the outer wall of the sample dropping needle 31 can be cleaned, and the cleaning is simple and convenient.
It is understood that, in order to facilitate the circulation of the cleaning liquid, the cleaning swab 70 may be provided with a liquid inlet channel 72 and a liquid outlet channel 73 which are communicated with the cleaning channel 71, when the sample dropping needle 31 is cleaned, the sample dropping needle 31 moves up and down along the cleaning channel 71, and the cleaning liquid is input into the cleaning channel 71 from the liquid inlet channel 72 and flows out from the liquid outlet channel 73.
Alternatively, in order to allow the sample dropper 31 to smoothly pass through the puncture hole of the puncture needle 21, the second through hole of the puncture connecting plate 22, the puncture hole of the puncture needle 21, and the cleaning channel 71 of the cleaning swab 70 may be coaxially arranged.
Optionally, the cleaning channel 71 of the cleaning swab 70 may include a guiding section 711, a cleaning section 712, and a mounting section 713, which are sequentially arranged, the guiding section 711 is used for guiding the movement of the sample dropping needle 31, so as to avoid position deviation when the sample dropping needle 31 is sampled, the liquid inlet channel 72 communicates with the cleaning section 712, the cleaning of the outer wall of the sample dropping needle 31 is achieved in the cleaning section 712, and the needle tail end of the puncture needle 21 may be inserted into the mounting section 713 and be in matching connection with the mounting section 713.
Alternatively, the ratio of the inner diameter of the guide section 711 to the outer diameter of the sampling needle 31 may be 1.05 to 1.12.
It will be appreciated that the diameter of the cleaning section 712 and the mounting section 713 is larger than the guide section 711 to facilitate movement of the drip needle 31.
In addition, the embodiment of the invention also provides a sample analyzer, which comprises the sampling device.
In accordance with the above-described embodiments of the present invention, these embodiments are not intended to be exhaustive or to limit the invention to the precise embodiments disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best utilize the invention and various embodiments with various modifications as are suited to the particular use contemplated. The invention is limited only by the claims and their full scope and equivalents.
Claims (12)
1. A sampling device, comprising:
a puncture assembly including a puncture needle having a puncture needle hole;
a sample drip assembly including a sample drip needle that is capable of passing through the puncture needle bore of the puncture needle.
2. The sampling device of claim 1, wherein the tip end and the tail end of the drip needle have a concentricity tolerance of no more than 0.1 mm;
preferably, the needle head end is provided with a spherical end face, a sample dropping needle hole of the sample dropping needle penetrates through the needle head end, and the hole wall of the sample dropping needle hole is in arc transition connection with the spherical end face;
preferably, the roughness of the inner wall and the outer wall of the needle head end is not more than 0.1 μm.
3. The sampling device of claim 1, wherein the puncture needle comprises a needle tip having a beveled edge, the beveled edge being angled at an angle of 25 ° -35 ° relative to the direction of extension of the puncture needle;
preferably, the beveling cutting edge is in arc transition connection with both the inner wall and the outer wall of the needle tip, and the radius of a transition arc is 0.02-0.05 mm;
preferably, the roughness of the inner wall and the outer wall of the needle tip and the bevel of the beveling edge are not more than 0.4 μm.
4. The sampling device of claim 1, further comprising a base, the base comprising a body portion, a first bracket and a second bracket movably connected to the body portion, the puncture assembly being connected to the first bracket, the drip assembly being connected to the second bracket, the puncture needle and the drip needle both extending in a first direction, the second bracket being capable of driving the drip needle to pass through the puncture needle hole of the puncture needle.
5. The sampling device of claim 4, wherein the drip needle and the puncture needle are coaxially arranged, and the puncture needle is sleeved outside the drip needle.
6. The sampling device of claim 4, characterized in that, the dropping sample subassembly includes the dropping sample connecting plate and makes the dropping sample needle be in follow on the second support the installation department that first direction extends, the dropping sample connecting plate with the second leg joint, the installation department includes fixed cover, elastic component and the installation piece that has the mounting groove, the installation piece with the dropping sample connecting plate links to each other, the dropping sample connecting plate with all be equipped with on the installation piece and be used for the first through-hole that the dropping sample needle passed, fixed cover with the elastic component set up in the mounting groove, the needle tail end of dropping sample needle runs through fixed cover and with fixed cover is fixed continuous, the elastic component cover is in the dropping sample needle outside and set up in fixed cover with between the installation piece.
7. The sampling device of claim 4, further comprising a guide assembly including a rail disposed on the body portion and first and second sliders slidably coupled to the rail, the rail extending along the first direction, the first slider fixedly coupled to the first bracket and the second slider fixedly coupled to the second bracket.
8. The sampling device of any one of claims 4 to 7, further comprising a drive assembly including a first driver and a second driver, the first driver driving the first support to move in the first direction to cause the puncture needle to puncture a blood collection tube, the second driver driving the second support to move in the first direction to cause the drip needle to pass through the puncture hole of the puncture needle and into the blood collection tube to complete sampling.
9. The sampling device of claim 8, wherein the first driver and the second driver are both screw motors, the first driver includes a first body and a first screw nut disposed in the first body, the second driver includes a second body and a second screw nut disposed in the second body, the driving assembly further includes a screw extending along the first direction, the screw is fixedly connected to the main body, the first screw nut and the second screw nut are both in threaded connection with the screw, the first bracket is connected to the first body, and the second bracket is connected to the second body.
10. The sampling device according to claim 4, further comprising a cleaning swab, wherein the cleaning swab is provided with a cleaning channel extending along the first direction, the puncture assembly further comprises a puncture connecting plate, the puncture connecting plate is provided with a second through hole allowing the sample dripping needle to pass through, the puncture connecting plate is connected to the first bracket, the cleaning swab is connected to the puncture connecting plate, the puncture needle is connected to the cleaning swab, the second through hole is communicated with the cleaning channel of the cleaning swab, and the puncture needle hole of the puncture needle is communicated with the cleaning channel.
11. The sampling device as recited in claim 10, wherein the cleaning channel of the cleaning swab comprises a guide section, a cleaning section and a mounting section which are arranged in sequence, the ratio of the inner diameter of the guide section to the outer diameter of the sample dripping needle is 1.05-1.12, and the tail end of the puncture needle is connected with the mounting section in a matching manner.
12. A sample analyser comprising a sampling device according to any one of claims 1 to 11.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011170607.6A CN112378705A (en) | 2020-10-28 | 2020-10-28 | Sampling device and sample analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011170607.6A CN112378705A (en) | 2020-10-28 | 2020-10-28 | Sampling device and sample analyzer |
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| Publication Number | Publication Date |
|---|---|
| CN112378705A true CN112378705A (en) | 2021-02-19 |
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| CN202011170607.6A Pending CN112378705A (en) | 2020-10-28 | 2020-10-28 | Sampling device and sample analyzer |
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| CN (1) | CN112378705A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113834710A (en) * | 2021-09-23 | 2021-12-24 | 睿科集团(厦门)股份有限公司 | Full-automatic liquid treatment workstation |
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