CN112353378A - Microcirculation detection device and system based on parallel structure detector - Google Patents

Microcirculation detection device and system based on parallel structure detector Download PDF

Info

Publication number
CN112353378A
CN112353378A CN202011216629.1A CN202011216629A CN112353378A CN 112353378 A CN112353378 A CN 112353378A CN 202011216629 A CN202011216629 A CN 202011216629A CN 112353378 A CN112353378 A CN 112353378A
Authority
CN
China
Prior art keywords
parallel structure
microcirculation
light
probe
parallel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202011216629.1A
Other languages
Chinese (zh)
Inventor
陆菡
于布为
邬崇朝
陈博
迟晓梅
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Jiaotong University
Ruinjin Hospital Affiliated to Shanghai Jiaotong University School of Medicine Co Ltd
Original Assignee
Shanghai Jiaotong University
Ruinjin Hospital Affiliated to Shanghai Jiaotong University School of Medicine Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Jiaotong University, Ruinjin Hospital Affiliated to Shanghai Jiaotong University School of Medicine Co Ltd filed Critical Shanghai Jiaotong University
Priority to CN202011216629.1A priority Critical patent/CN112353378A/en
Publication of CN112353378A publication Critical patent/CN112353378A/en
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026Measuring blood flow
    • A61B5/0261Measuring blood flow using optical means, e.g. infrared light

Abstract

The invention discloses a microcirculation detection device and system based on a parallel structure detection body, wherein when the microcirculation detection is carried out, a parallel structure detection head horizontally extends into the detection head and is in contact with the surface of a tissue including a tongue, an illuminating light beam is projected onto the surface of the tissue including the tongue, an imaging receiving channel collects reflected light scattered and absorbed in the tissue, the collected light is changed into a light path through a reflector so as to be parallel to the detection head body and transmitted out, and an imaging capture device focuses the light beam to be processed into image data. Because the parallel structure detecting head is adopted, the detecting head is parallel to the tongue when in microcirculation detection, and is not in the vertical relation between the traditional detecting body and the tongue, thereby not only achieving the close fit, but also not applying excessive pressure to the tongue. Moreover, the detecting body can be used in cooperation with various clinical conditions, and realizes real-time monitoring of sublingual microcirculation during visceral examination and operation of an endoscope.

Description

Microcirculation detection device and system based on parallel structure detector
Technical Field
The invention belongs to the field of design of microcirculation monitoring, and particularly relates to a microcirculation detection device and system based on a parallel structure detector.
Background
Microcirculation refers to the circulation of blood between the oligodynamic and the venules. The most fundamental function of the blood circulation is to perform the exchange of substances between blood and tissues, which is performed in the microcirculation part. In recent years, microcirculation has been considered the ultimate destination of the cardiovascular system responsible for the supply of oxygen to tissues by red blood cell transport, and is considered the primary "responsible" for tissue health because it is a crucial factor affecting tissue oxygen supply. The ultimate goal of fluid therapy is to improve perfusion at the level of microcirculation. Only fluid therapies that improve microcirculation and correct clinical parameters that reflect hypovolemia (e.g., tachycardia, oliguria, hyperlactacidosis, or hypo-venous oxygen saturation) will have a positive impact on the patient's condition.
Sublingual microcirculation is gradually emphasized in clinical application due to its advantages of convenience at bedside, non-invasiveness, and the like. Currently, the microcirculation monitoring means used clinically mainly include orthogonal polarization spectroscopy, lateral flow dark field imaging, laser doppler imaging, near infrared spectroscopy, pulse oximetry monitoring, laser scanning confocal microscopy, and the like. The first generation of Orthogonal Polarization Spectroscopy (OPS) and hand-held electron microscopy opened a new era of microcirculation monitoring by studying the microcirculation of exposed tissues and organs of the human body. The second generation of lateral flow dark field imaging (SDF) is currently the most widely used means for monitoring microcirculation changes in clinical studies [ Milstein DM, Lindeboom JA, Inc. C. internal personal digital field (SDF) imaging used in a clinical model for connecting biological monitoring and quantification of biological monitoring and regeneration of biological monitoring and surrounding health in the same clinical practice: a pilot study [ J ] Arch organic biol.2010, 55(5): 343 349 ]. . The third generation is a handheld dark field microscope based on Incident dark field imaging mode (IDF), which is a successor to lateral flow dark field imaging (SDF), with the advantages of improved optical resolution. The SDF optically isolates incident light from reflected light, while the IDF illuminates the entire monitoring area in a hemoglobin absorption dark field manner, so that the IDF provides an advantage of increasing the field area of view.
CN 103445764B, entitled "monitoring device and method for microcirculation imaging", adopts the concept that the transmission depth of polarized light in human tissue can be adjusted, and the field of view and resolution of the device can be adjusted in real time, so as to realize more detailed observation of specific area of microcirculation imaging.
US 2013/0237860 a1, entitled "system and method for monitoring microcirculation overall", discloses an improved imaging of microcirculation by illuminating the tip of a light guide with external direct light to achieve reflection avoidance, i.e. the incident and reflected light do not travel along the same path.
CN 205322304U, entitled "device for obtaining clear microcirculation image", adopts tiny light source projection devices uniformly distributed around the imaging light-passing area, the light emission direction of the tiny light source projection devices forms a projection angle with the direction perpendicular to the object to be detected, and obtains a clear image without being affected by reflected light on the basis of no need of using polarized light.
Above-mentioned patent document has all made the improvement to microcirculation imaging effect, but its microcirculation monitoring handheld device exists because of anterior segment detection part is perpendicular with sublingual, exerts too much pressure influence detection effect and because of anterior segment detection part is shorter and whole detecting instrument is heavier to sublingual when surveying, leads to the not good technical problem of its detection effect precision from this. Moreover, the medical staff can not realize continuous long-term monitoring because of holding the equipment by hand.
Disclosure of Invention
The invention aims to provide a microcirculation detection device and a microcirculation detection system based on a parallel structure detection body, which can realize continuous and real-time accurate monitoring of sublingual apposition blood vessels, fundamentally solve the problems of unstable imaging caused by physiological shaking of an operator due to a handheld instrument, sublingual bleeding due to compression of a probe and the like, greatly improve the safety and the practicability of a patient in microcirculation monitoring, and reduce the working difficulty of an operator.
In order to solve the problems, the technical scheme of the invention is as follows:
a microcirculation detection device based on parallel structure probe body, includes parallel structure detecting head, parallel structure detecting head further includes:
the light source is arranged on the side wall of the front end of the parallel structure probe body, and an illumination light beam provided by the light source is projected to the surface of a tissue including the tongue;
the imaging receiving channel comprises a reflector, the reflector is arranged below the light source and is obliquely arranged in the body of the parallel structure detecting head, and the oblique angle is set to change the light path of the collected light to enable the collected light to be parallel to the body of the parallel structure detecting head and be transmitted out;
the imaging capture device is used for receiving the light transmitted by the imaging receiving channel and focusing the light into a light beam for transmission so as to be post-processed into microcirculation image information;
when the microcirculation detection is carried out, the parallel structure detection head horizontally extends into the detection head and is in contact with the surface of the tissue including the tongue, the illuminating light beams are projected onto the surface of the tissue including the tongue, the imaging receiving channel collects the reflected light scattered and absorbed in the tissue, and changes the light path of the collected light to be parallel to the detection head body of the imaging capturing device so as to enable the collected light to be focused into the light beams for transmission.
One scheme is as follows: the imaging capture device further comprises a flexible optical fiber for transmitting the optical information received by the imaging receiving channel.
The other implementation scheme is as follows: the imaging and capturing device further comprises a lens structure and a flexible optical fiber, wherein the lens structure is used for focusing the parallel light path of the imaging and receiving channel into a light spot with the diameter smaller than the inner diameter of the flexible optical fiber, and the flexible optical fiber is used for carrying out light transmission on the light rays collected by the lens structure.
The microcirculation detection device based on the parallel structure detector further comprises a CCD and an image processing module, the CCD is used for receiving image acquisition of incident light spots of the flexible optical fiber, and the image processing module is used for processing images acquired by the CCD into sublingual microcirculation image data.
The reflector is directly fixed in the parallel structure detecting head through a bracket or a fixing structure.
The utility model provides a parallel structure surveys body microcirculation system, its at least includes oral cavity fixed bolster, as above-mentioned microcirculation detection device, parallel structure surveys body microcirculation device includes parallel structure probe and image processing portion at least, but parallel structure probe independent setting to swing joint is on oral cavity fixed bolster, oral cavity fixed bolster with when parallel structure probe is connected, fixes the position of parallel structure probe.
The oral cavity fixing support can be fixed in the oral cavity of a user, a through hole for placing the tongue of the user is formed in the end face of the oral cavity fixing support, and a micro-circulation probe socket for inserting the parallel structure probe is formed below the through hole.
Further, the oral cavity fixed bolster is the arc, microcirculation probe socket is seted up in on the middle terminal surface of oral cavity fixed bolster, the end of parallel structure detecting head with microcirculation probe socket matches and links firmly.
Still be equipped with the scope socket on the middle terminal surface of oral cavity fixed bolster, the scope socket is followed the centre of a circle direction of oral cavity fixed bolster is equipped with an extension section, the side of extension section is equipped with trachea socket.
Due to the adoption of the technical scheme, compared with the prior art, the invention has the following advantages and positive effects:
1) aiming at the problem that the conventional microcirculation monitoring handheld device is vertical to the tongue and can cause pressure to the sublingual mucosa and subcutaneous blood vessels of a patient during detection, the microcirculation monitoring handheld device in the embodiment of the invention has the advantages that the detection part is parallel to the tongue instead of vertical relation, so that the close fit is achieved, the pressure to the sublingual mucosa and subcutaneous blood vessels of the patient is reduced, and the experience degree of the patient is improved without influencing the detection effect.
2) Aiming at the problems that the existing sublingual microcirculation monitoring system is based on handheld operation, the probe is hard in texture, an operator shakes the tongue unintentionally to cause damage, and the operator holds the tongue very inconveniently for a long time, the monitoring probe is fixed under the tongue through the oral cavity fixing support, so that the sublingual microcirculation monitoring at the same position is obtained continuously and in real time.
3) In the parallel-structure probe microcirculation system in an application example, as the oral cavity fixing support is also provided with the endoscope socket and the trachea socket, the endoscopy of the patient with trachea cannula and the sublingual microcirculation monitoring can be synchronously carried out, so that the patient can continuously monitor the sublingual microcirculation while the viscus examination and the operation of the endoscope are carried out.
Drawings
FIG. 1 is a schematic diagram of a prior art sublingual microcirculation probe according to the present invention;
FIG. 2 is a schematic diagram of a parallel structure probe micro-circulation device in accordance with one embodiment of the present invention;
FIG. 3 is a schematic view of a parallel structure probe head in accordance with one embodiment of the present invention;
FIG. 4 is a schematic view of sublingual microcirculation detection in accordance with an embodiment of the present invention;
fig. 5 is a schematic structural diagram of an oral fixing bracket in an application example of the present invention.
Description of reference numerals:
1: a parallel structure probe; 101: a housing; 102: a light source; 103: a reflective mirror; 104: a wedge-shaped structural member; 105: a limiting member; 2: an oral fixation support; 201: a microcirculation probe socket; 2011: a clamping groove; 202: an endoscope socket; 203: an extension section; 204: a trachea socket; 205: and a semicircular opening.
Detailed Description
The invention provides a parallel structure probe microcirculation device which is further explained in detail by combining the attached drawings and the specific embodiment. Advantages and features of the present invention will become apparent from the following description and from the claims.
The current microcirculation monitoring is only clinical scientific research equipment, but cannot become clinical routine detection equipment. Mainly because the following technical defects are not solved: 1. during monitoring, the probe contacts the tongue, and if the operator does not control the force properly, mucous membranes and subcutaneous blood vessels are easily squeezed, and even the blood vessels are broken; 2. the hand-held microcirculation monitor is heavy in whole, an operator cannot perform continuous monitoring at the same position for a long time, and the patient can be injured by physiological shaking of the operator. 3. The current probe sticks to the tongue closer and perpendicular (as shown in figure 1), and is easy to extrude mucosa and subcutaneous blood vessels; 4. the requirement on operators is high. The probe is close to the tongue, so that mucosa and subcutaneous blood vessels are easily extruded; the probe is far from the tongue, which affects the quality of collected video; 5. the observation fields detected in time-sharing are difficult to be consistent, so that the microcirculation at the same part cannot be continuously monitored and analyzed; 6. the movement of the patient and the operator, secretions (saliva, blood, etc.) in the oral cavity, and the like affect the accuracy of the monitoring result. The defects all seriously affect the imaging quality and finally affect the clinical application and popularization of the microcirculation monitoring instrument.
In order to solve the above problems, the present embodiment provides a microcirculation detection device based on a parallel structure detector, which can realize the monitoring of the same position, continuous and real-time sublingual microcirculation, and avoid unnecessary damage to the patient. In addition, the invention also provides an application example of the microcirculation detection device based on the parallel structure detection body, the oral cavity fixing bracket for fixing is arranged, and the sockets of the medical endoscope and the trachea cannula are reserved at the oral cavity fixing bracket respectively, so that the microcirculation monitoring and the operations of the medical endoscope examination, the trachea cannula and the like can be carried out simultaneously, and the microcirculation detection device has extremely high application potential in the aspects of the visceral examination, the operation and the like of the endoscope.
Examples
Referring to fig. 3 and 4, a microcirculation device for parallel structure probe includes a parallel structure probe head 1, where the parallel structure probe head 1 further includes:
a light source 102 disposed on a side wall of the front end of the parallel structure probe body, the light source providing an illumination beam projected onto a tissue surface including under the tongue;
the imaging receiving channel comprises a reflector 103, the reflector 103 is arranged below the light source 102 and is obliquely arranged in the body of the parallel structure detecting head, and the oblique angle is set to change the light path of the collected light to enable the collected light to be parallel to the body of the detecting head and be transmitted out;
the imaging receiving channel comprises a reflector, the reflector is arranged below the light source and is obliquely arranged in the body of the parallel structure detecting head, and the oblique angle is set to change the light path of the collected light to enable the collected light to be parallel to the body of the detecting head and be transmitted out;
the imaging capture device is used for receiving the light transmitted by the imaging receiving channel and focusing the light into a light beam for transmission so as to be post-processed into microcirculation image information;
when the microcirculation detection is carried out, the parallel structure detection head horizontally extends into the detection head and is in contact with the surface of the tissue including the tongue, the illuminating light beam is projected onto the surface of the tissue including the tongue, the imaging receiving channel collects the light scattered in the tissue and returned to the surface of the tissue, and the collected light changes the light path to be parallel to the detection head body of the imaging capturing device and is focused into the light beam for transmission.
The structure of the present invention will be specifically described below.
Light source 102 may be configured to provide incident light at a wavelength λ, where λ > 0. Specifically, "light" emitted by the light source 102 includes, but is not limited to: pulsed xenon arc or lamp, mercury arc or lamp, halogen Light or lamp, tungsten arc or lamp, laser Diode or Light Emitting Diode (LED for short). "light" may also be classified as coherent or incoherent light, and thus light source 102 may be a coherent or incoherent light source. In one embodiment, the wavelength λ of the incident light provided by the light source 102 is determined by the absorption spectra of hemoglobin and deoxyhemoglobin in the microcirculation. In the absorption spectra of hemoglobin and deoxyhemoglobin, 420nm (nanometers), 550nm and 800nm are equal absorption peaks of hemoglobin and deoxyhemoglobin. The wavelength of the incident light provided by the light source 102 in this embodiment is 530nm, but is not limited to 530nm, and may also be 540nm or 550 nm.
The light source 102 is not only a single light source, but also a plurality of light source modules, in this case, the light source can be disposed on the side wall of the front end of the parallel structure probe body. It should be noted that the probe body with a parallel structure mainly defines the front end and the rear end artificially. In use, the end part of the parallel structure probe body contacting with the sublingual space is defined as a front end, and the end part convenient for an operator to hold is defined as a rear end. That is, the light source 102 is disposed at the end of the end that contacts the tongue, and is spaced slightly from the tongue contact, primarily to facilitate the projection of the illumination beam provided by the light source onto the tissue surface, including under the tongue.
One common practice is to form a plurality of holes in the housing of the parallel structure probe body, and install the light source modules in the holes respectively, and set the light source modules that can provide the illuminating beams to be at an angle with the horizontal. Several processing schemes are possible with this example. For example, each light source of the light source assembly is transversely or longitudinally arranged on the side wall of the front end of the parallel structure detecting head body, and the system can control the light sources at different positions to work according to the sublingual difference of people of different ages or sexes, so that the universality of the parallel structure detecting head is improved. For another example, the angle between the light source module and the horizontal direction is adjustable, and during the micro-cycle detection, the operator can adjust the angle so as to adjust the illumination angle of the illumination beam. The light penetration depth can be related to the incident angle of the light, so that microcirculation images with different depths in human tissues can be obtained by adjusting the incident angle of the incident light.
It should be noted that the light source 102 mentioned in this example is a relatively large concept, and includes not only the light source 102 in a narrow sense but also the light source 102 in a broad sense. The light source 102 in the broad sense includes not only a light source generating part for providing an illumination light beam but also a light processing part for performing a secondary processing on the generated light beam to have a better incident light effect. Such as: the device also comprises a condenser lens and the like which are used for converging and collimating the generated illumination light beams.
The detection principle of the tongue base microcirculation is briefly described as follows: in imaging microcirculation with orthogonally polarized light, when polarized light is incident under the tongue, a portion of the polarized light is reflected directly by the sublingual surface, and another portion is transmitted through the tongue into the sublingual tissue. In any one scattering, the polarization state of the incident light may change. Where light that is directly reflected or only slightly transmitted into the sublingual surface is only scattered one or a few times before being re-reflected, most of the polarized light will retain its original polarization; light penetrating deeply into sublingual tissue becomes unpolarized light after multiple scattering, and the depolarized unpolarized light returns to the sublingual surface after multiple scattering in human body tissue.
Polarized light is projected into a second medium with refractive index n2 at an incident angle theta 1 in a first medium with refractive index n1, and the refraction angle of the polarized light in the second medium is theta 2.
Since the light penetration depth is related to the incident angle of light, the microcirculation images at different depths under the tongue can be obtained by adjusting the incident angle of the incident polarized light.
According to the fresnel reflection formula, the transmittance (transmission) τ of a light ray propagating in two isotropic media satisfies the following relationship:
τ=2n1*cosθ1/(n2*cosθ1+n1*cosθ2) (1)
in this embodiment, the first medium is an incident medium, such as air, and the second medium is sublingual tissue, so in formula (1), n1 is the refractive index of the incident medium, n2 is the refractive index of the sublingual tissue, the incident angle θ 1 is the angle at which the polarized light is transmitted from the air to the sublingual skin surface, and the refraction angle θ 2 is the refraction angle at which the polarized light is transmitted into the sublingual tissue.
The transmittance of the polarized light in the second medium is changed along with the change of the incident angle theta, so that light rays scattered back by human tissues with different depth levels can be acquired through subsequent imaging components, and microcirculation images with different depths in the human tissues are acquired after processing.
After the light source irradiates the sublingual tissue, scattered light containing sublingual microcirculation information is formed under the tongue. The image receiving channel transmits the collected scattered light rays out so that the image capturing device can acquire relevant image information.
The imaging receiving channel comprises a reflector 103, the reflector 103 is arranged below the light source 102 and is obliquely arranged in the body of the parallel structure detection head, and the oblique angle is set to change the light path of the collected light so that the collected light is transmitted out in a way of being parallel to the body of the detection head. The mirror 103 may be fixed to the bottom of the body of the parallel structure probe by a bracket, or may be fixed to the body of the parallel structure probe by a nut or the like. The angle of inclination of the mirror 103 can also be made fine-tunable for convenient reception of effective light information. In this example, in view of the more compact structure of the parallel structure probe, both ends of the reflecting mirror 103 may be fixed to the front bottom and side portions of the parallel structure probe body, respectively. The image receiving channel can also be provided with a plurality of optical elements, and mainly carries out secondary processing on the received light.
And an image capturing device (not shown) for receiving the light transmitted by the image receiving channel and focusing the light into a light beam for post-processing into micro-circulation image information.
One embodiment is as follows: the imaging capturing device further comprises a flexible optical fiber for transmitting the optical information received by the imaging receiving channel, namely, if the flexible optical fiber can directly receive the optical signal, the optical signal can be directly transmitted through the optical fiber.
In another embodiment, the image capturing device further includes a lens structure and a flexible optical fiber, the lens structure is used for focusing the parallel optical path of the image receiving channel into a light spot with a diameter smaller than the inner diameter of the flexible optical fiber, and the flexible optical fiber optically transmits the light collected by the lens structure. The lens structure can be newly arranged in the embodiment, for example, only one plano-convex lens is directly used, the distance between the reflector and the lens is adjusted, and light spots smaller than the inner diameter of the flexible optical fiber can be observed on the other side. In addition, if the spot quality of the focused spot is required, a diaphragm can be added to filter out stray light. The above disclosure is only an example, and there are many possible implementations of the lens structure, and this example is not intended to limit the present invention.
Jian Zhao et al proposed a new generation of fiber Imaging systems based on deep Learning and Anderson local area fibers (ZHao J, SunY, ZhuZ, et al. The system has simple structure, low cost and extremely high robustness. The optical fiber imaging system can transmit the image of the defect-free cells at high speed and real time at 20Hz under a non-relevant broadband light source. Moreover, the system can still maintain high-speed and high-quality cell image transmission under the mechanical bending disturbance and severe temperature change, and the imaging depth can be extended to be about 4mm under the lens-free state. The invention can also directly adopt the optical fiber imaging system, and the system adopts the Anderson local optical fiber which comprises an incoherent broadband illumination light source, a power-adjustable operation laser light source, an optical fiber wavelength division multiplexer, an optical fiber side-throwing coupler, the Anderson local optical fiber with annular waveguide and a camera system. The Anderson local area optical fiber is directly installed in the probe head body, but the horizontal structure of the probe head body is needed.
In this example, the parallel structure probe-based microcirculation detection device further includes an image processing section, which further includes:
CCD: it converts the received light beam information containing optical image into digital information;
an image processing module: for processing the received image data information into viewable imaged graphics or video.
In this embodiment, the parallel structure probe-based microcirculation detection device further comprises a data processor. The data processor is used for receiving the imaged digital image signal and carrying out image processing on the digital image signal so as to analyze and measure the human tissue and obtain human microcirculation information.
Application example
As shown in fig. 2, the microcirculation system of the parallel structure probe body at least comprises an oral cavity fixing bracket and the microcirculation probe device based on the parallel structure probe body in the above embodiment, the microcirculation probe device based on the parallel structure probe body at least comprises a parallel structure probe head and an image processing part, the parallel structure probe head can be separately arranged and can be movably connected on the oral cavity fixing bracket, and when the oral cavity fixing bracket is connected with the parallel structure probe head, the position of the parallel structure probe head is fixed. The parallel structure probe microcirculation device.
The parallel structure probe microcirculatory system comprises: parallel structure detecting head 1 and oral cavity fixed bolster 2, parallel structure detecting head 1 and oral cavity fixed bolster 2 link firmly.
Specifically, referring to fig. 3, the parallel structure probe 1 includes a housing 101, a light source 102, a reflecting mirror 103, a wedge-shaped structural member 104, and a limiting member 105. The housing 101 is cylindrical, and a light source 102 is provided on the front end side wall of the housing 101, and the light source 102 irradiates the sublingual area when sublingual microcirculation monitoring is performed.
A reflector 103 is arranged below the light source 102, the reflector 103 is obliquely arranged in the shell 101, when sublingual microcirculation monitoring is carried out, a light beam containing sublingual microcirculation information is formed on the sublingual surface after the light source 102 irradiates the sublingual, and the light beam changes the direction of the light path after passing through the reflector 103 and is transmitted out in parallel to the parallel structure detection head 1.
A plurality of wedge-shaped structures 104 are disposed on the outer side wall of the end of the casing 101, and as can be seen from fig. 3, 4 wedge-shaped structures 104 are disposed on the outer side wall of the end of the casing 101 and are uniformly distributed on the side wall to form a ring shape. Of course, according to actual requirements, other numbers of wedge-shaped structural members 104 may be provided, and the arrangement positions of the wedge-shaped structural members 104 may also be adjusted. These wedge-shaped structures 104 are intended to be fixedly connected to the oral cavity fixation support 2.
A limiting member 105 is further disposed on an outer side wall of the distal end of the housing 101, and the limiting member 105 is located behind the wedge-shaped structural member 104 and is used for limiting the length of the parallel structure probe 1 extending into the oral cavity and preventing the parallel structure probe 1 from moving in a direction perpendicular to the oral cavity fixing bracket 2. The limiting member 105 may be a ring sleeved at the end of the parallel structure probe 1, or may be a structural member of other shape, as long as the specific limiting function is achieved, the length of the parallel structure probe 1 extending into the oral cavity is limited, and the function of preventing the parallel structure probe 1 from moving in the direction perpendicular to the oral cavity fixing support 2 is also achieved.
When sublingual microcirculation monitoring was performed, as shown in fig. 4. Because the parallel structure probe head 1 is parallel to the tongue, but not perpendicular to the tongue, the tongue can be tightly attached, and excessive pressure can not be applied to the tongue. The parallel structure probe head 1 effectively avoids the impact and the compression of the cylindrical probe head under the tongue in the current design, thereby effectively realizing the continuous monitoring.
In order to further control the pressure on the sublingual observation part, the pressure sensor is arranged at the detection front end of the parallel structure detection head 1, and a user can adjust the detection distance between the parallel structure detection head 1 and sublingual microcirculation according to the feedback of the pressure sensor, so that the problems that mucosa and subcutaneous blood vessels are squeezed due to the fact that the parallel structure detection head is attached to the sublingual closely, or the quality of collected video is influenced due to the fact that the detector is far away from the sublingual are solved.
Referring to fig. 5, the oral cavity fixing bracket 2 is arc-shaped, a microcirculation probe socket 201 is formed on the middle end surface of the oral cavity fixing bracket 2, the microcirculation probe socket 201 is a circular hole, the diameter of the circular hole is matched with the diameter of the tail end of the parallel structure probe 1, and the tail end of the parallel structure probe 1 is inserted into the microcirculation probe socket 201. The inner wall of the microcirculation probe socket 201 is provided with a plurality of clamping grooves 2011, and the positions and the number of the clamping grooves 2011 correspond to the positions and the number of the wedge-shaped structural members 104 at the tail end of the parallel structure probe 1. After the parallel structure probe 1 is inserted into the microcirculation probe socket 201, the wedge-shaped structural member 104 is clamped into the clamping groove 2011, so that the parallel structure probe 1 is fixedly connected with the oral cavity fixing support 2, and the parallel structure probe 1 is prevented from rotating and horizontally moving. And after the wedge-shaped structural member 104 is clamped in the clamping groove 2011, the limiting member 105 at the tail end of the parallel structure detecting head 1 clamps the opening of the micro-circulation probe socket 201, so that the length of the parallel structure detecting head 1 extending into the oral cavity is limited, and the parallel structure detecting head 1 is also used for preventing the parallel structure detecting head 1 from moving in the direction perpendicular to the oral cavity fixing support 2.
An endoscope socket 202 is further arranged on the middle end face of the oral cavity fixing support 2, as can be seen from fig. 5, the endoscope socket 202 is cylindrical, an extension section 203 is arranged on the endoscope socket 202 along the direction of the circle center of the oral cavity fixing support 2, and the extension section 203 is a cylindrical ring. The side surface (circular arc surface) of the extension section 203 is provided with a tracheal insertion opening 204, a tracheal cannula can be inserted, and smooth breathing of a patient during monitoring is guaranteed. The lower end surface (lower plane) of the extension section 203 is provided with a semicircular opening 205, which is convenient for the tongue of the patient to be placed.
The oral cavity fixing support 2 can be prepared by 3D integrated printing, and the material can be multi-material resin polymer.
The parallel structure probe microcirculation system that this embodiment provided adopts oral cavity fixed bolster not only to guarantee continuous, real-time accurate monitoring to sublingual apposition blood vessel, has solved in addition fundamentally and has caused the formation of image unstability that the operator physiology was rocked and is brought because of handheld instrument, and sublingual because of the probe oppression bleeds scheduling problem, has greatly improved the security and the practicality that the patient monitored time measuring, has also reduced operator's the work degree of difficulty. And can be used with the scope, realize in the internal organ inspection, during the operation, carry out real-time supervision to sublingual microcirculation. And because the parallel structure detecting head is adopted, the probe is parallel to the tongue when in microcirculation detection, and is not in a vertical relation in the traditional detecting body, thereby not only achieving close fit, but also not applying excessive pressure to the tongue. The parallel structure probe head effectively avoids the impact and the compression of the probe head under the tongue in the prior design.
The embodiments of the present invention have been described in detail with reference to the accompanying drawings, but the present invention is not limited to the above embodiments. Even if various changes are made to the present invention, it is still within the scope of the present invention if they fall within the scope of the claims of the present invention and their equivalents.

Claims (9)

1. A microcirculation detection device based on parallel structure probe body, characterized in that, including the parallel structure probe head, the parallel structure probe head further includes:
the light source is arranged on the side wall of the front end of the parallel structure detection head body, and an illuminating light beam provided by the light source is projected to the surface of a tissue including the tongue;
the imaging receiving channel comprises a reflector, the reflector is arranged below the light source and is obliquely arranged in the body of the parallel structure detecting head, and the oblique angle is set to change the light path of the collected light to enable the collected light to be parallel to the body of the parallel structure detecting head and be transmitted out;
the imaging capture device is used for receiving the light transmitted by the imaging receiving channel and focusing the light into a light beam for transmission so as to be processed into microcirculation image information in the following step;
when the microcirculation detection is carried out, the parallel structure detection head horizontally extends into the parallel structure detection head and is in contact with the surface of the tissue including the tongue, the illuminating light beams of the light source are projected onto the surface of the tissue including the tongue, the imaging receiving channel collects the reflected light scattered and absorbed in the tissue, and the collected light changes the light path of the collected light to be parallel to the body of the parallel structure detection head for the imaging capture device to focus into the light beams for transmission.
2. The parallel structure probe-based microcirculation detection device of claim 1, wherein the image capture device further includes a flexible optical fiber for transmitting the optical information received by the image receiving channel.
3. The parallel structure probe-based microcirculation detection device of claim 1, wherein the image capture device further includes a lens structure and a flexible optical fiber, the lens structure is used for focusing the parallel light path of the image receiving channel to a light spot diameter smaller than the inner diameter of the flexible optical fiber, and the flexible optical fiber is used for transmitting the light collected by the lens structure.
4. The parallel structure probe-based microcirculation detection device of claim 2, further comprising a CCD for collecting the image of the incident light spot of the flexible optical fiber, and an image processing module for processing the image collected by the CCD into sublingual microcirculation image data.
5. The parallel structure probe-based microcirculation detection device of claim 1, wherein the reflector is fixed directly in the body of the parallel structure probe by a bracket or a fixing structure.
6. A parallel structure probe body microcirculation system, which comprises at least an oral cavity fixing bracket, a microcirculation detection device based on parallel structure probe body as claimed in any one of claims 1 to 5, said microcirculation detection device based on parallel structure probe body at least comprises parallel structure probes and an image processing part, said parallel structure probes can be separately arranged and movably connected on the oral cavity fixing bracket, when said oral cavity fixing bracket is connected with said parallel structure probes, the position of said parallel structure probes is fixed.
7. The parallel structure probe microcirculatory system of claim 6 wherein said oral cavity anchor bracket is adapted to be secured within the mouth of a user, said oral cavity anchor bracket having a through hole in an end surface thereof for receiving the tongue of a user, said through hole having a microcirculatory probe socket disposed therebelow for receiving, supporting and securing said parallel structure probe.
8. The parallel structure probe microcirculation system of claim 7, wherein the mouth fixing bracket is arc-shaped, the microcirculation probe socket is opened on the middle end face of the mouth fixing bracket, and the tail end of the parallel structure probe is fixedly connected with the microcirculation probe socket in a matching way.
9. The parallel structure probe microcirculatory system of claim 8 wherein said oral cavity securing bracket further comprises an endoscope socket on a middle face thereof, said endoscope socket having an extension along a center of said oral cavity securing bracket, said extension having a trachea socket on a side thereof.
CN202011216629.1A 2020-11-04 2020-11-04 Microcirculation detection device and system based on parallel structure detector Pending CN112353378A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202011216629.1A CN112353378A (en) 2020-11-04 2020-11-04 Microcirculation detection device and system based on parallel structure detector

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202011216629.1A CN112353378A (en) 2020-11-04 2020-11-04 Microcirculation detection device and system based on parallel structure detector

Publications (1)

Publication Number Publication Date
CN112353378A true CN112353378A (en) 2021-02-12

Family

ID=74512803

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202011216629.1A Pending CN112353378A (en) 2020-11-04 2020-11-04 Microcirculation detection device and system based on parallel structure detector

Country Status (1)

Country Link
CN (1) CN112353378A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113040723A (en) * 2021-06-01 2021-06-29 深圳市中医院 Tongue vein detection device and detection method
WO2022095944A1 (en) * 2020-11-04 2022-05-12 上海交通大学医学院附属瑞金医院 Parallel detection and/or hook type optical fiber transmission microcirculation monitoring device

Citations (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6690966B1 (en) * 1991-02-26 2004-02-10 Massachusetts Institute Of Technology Methods of molecular spectroscopy to provide for the diagnosis of tissue
US20100249607A1 (en) * 2008-09-26 2010-09-30 Massachusetts Institute Of Technology Quantitative spectroscopic imaging
JP2012085844A (en) * 2010-10-20 2012-05-10 Panasonic Corp Cover and optical tomographic image acquisition device installed with the same
CN103445764A (en) * 2013-09-04 2013-12-18 广州医软智能科技有限公司 Device and method for monitoring microcirculation imaging
CN103622674A (en) * 2013-11-15 2014-03-12 广州医软智能科技有限公司 Minitype microcirculation imaging monitoring device and method
US20140265305A1 (en) * 2013-03-15 2014-09-18 Steven L. Thompson Conduit coupling system and method
CN203914853U (en) * 2014-06-28 2014-11-05 吕清林 A kind of digital stomatology endoscope
CN104224135A (en) * 2014-10-20 2014-12-24 广州医软智能科技有限公司 Multilevel microcirculation condition monitoring device and method
CN104458758A (en) * 2014-12-31 2015-03-25 湘潭大学 Detection device for synthetic sapphire wafer
CN104905781A (en) * 2015-02-13 2015-09-16 林昌军 Encephalic physiological parameter collecting device and application
CN105378426A (en) * 2013-03-27 2016-03-02 精工波有限公司 Portable structured light measurement module/apparatus with pattern shifting device incorporating a fixed-pattern optic for illuminating a subject-under-test
CN105662388A (en) * 2016-01-12 2016-06-15 冯兴怀 Microcirculation shock monitor capable of achieving rapid and repeated positioning and monitor system and method
US20160235303A1 (en) * 2013-10-11 2016-08-18 The Trustees Of Columbia University In The City Of New York System, method and computer-accessible medium for characterization of tissue
CN106419854A (en) * 2016-06-03 2017-02-22 冯兴怀 Image stabilization and probe pressure control device for portable microcirculation detector
CN206044591U (en) * 2016-06-08 2017-03-29 中国美术学院 A kind of electronic oral cavity sight glass for being easy to check oneself
CN206342453U (en) * 2016-08-31 2017-07-21 黄丹莉 Ear-nose-throat department check device
CN206473308U (en) * 2016-06-03 2017-09-08 冯兴怀 A kind of hand-held microcirculation monitor image stabilization and probe pressure control device
EP3228241A1 (en) * 2016-04-08 2017-10-11 VDW GmbH Dental probe
CN206804477U (en) * 2017-06-14 2017-12-26 中央民族大学 A kind of measurement pipe stream mid-span particle diameter size granule grading and its optical system of distribution
CN107677644A (en) * 2017-08-23 2018-02-09 北京大学 A kind of detecting system and its detection method of multilayer tissue's bulk optics parameter
CN207101615U (en) * 2017-02-20 2018-03-16 吉林大学 Fixator for tracheal cannule
CN108452412A (en) * 2018-03-28 2018-08-28 青岛市市立医院 A kind of department of anesthesia's multichannel pars oralis pharyngis air-breather
WO2019112090A1 (en) * 2017-12-07 2019-06-13 한국광기술원 Composite imaging device for structural/functional images of tooth
CN109998724A (en) * 2018-10-08 2019-07-12 青岛大学 A kind of laser teeth operation device and its method
CN209733935U (en) * 2018-11-12 2019-12-06 南京市儿童医院 children external auditory canal endoscope
CN110584578A (en) * 2019-09-03 2019-12-20 奇鋐科技股份有限公司 Oral cavity detection device with replaceable detection head
CN209951995U (en) * 2019-03-25 2020-01-17 伍堂洪 Oropharynx air duct type tracheal catheter fixator
US10627615B2 (en) * 2017-08-07 2020-04-21 Olympus Corporation Endoscope distal end portion, endoscope, and optical adaptor
CN210355591U (en) * 2019-06-10 2020-04-21 梁小华 Multi-channel oropharyngeal ventilation device for anesthesia department
CN210542768U (en) * 2018-12-29 2020-05-19 右江民族医学院附属医院 Tracheal cannula fixer
WO2020136445A1 (en) * 2018-12-27 2020-07-02 Feres Vieira Jose Custodio Universal extra-oral support accessory for portable microscopes
US20200237231A1 (en) * 2017-02-22 2020-07-30 University Of Maryland, Baltimore Apparatus and method for tooth pulp vitality detection
CN211534942U (en) * 2019-12-20 2020-09-22 深圳市康泰健牙科器材有限公司 Antifog intraoral scanner probe sleeve
CN112336309A (en) * 2020-11-04 2021-02-09 上海交通大学 Optical fiber type sublingual microcirculation continuous monitoring device

Patent Citations (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6690966B1 (en) * 1991-02-26 2004-02-10 Massachusetts Institute Of Technology Methods of molecular spectroscopy to provide for the diagnosis of tissue
US20100249607A1 (en) * 2008-09-26 2010-09-30 Massachusetts Institute Of Technology Quantitative spectroscopic imaging
JP2012085844A (en) * 2010-10-20 2012-05-10 Panasonic Corp Cover and optical tomographic image acquisition device installed with the same
US20140265305A1 (en) * 2013-03-15 2014-09-18 Steven L. Thompson Conduit coupling system and method
CN105378426A (en) * 2013-03-27 2016-03-02 精工波有限公司 Portable structured light measurement module/apparatus with pattern shifting device incorporating a fixed-pattern optic for illuminating a subject-under-test
CN103445764A (en) * 2013-09-04 2013-12-18 广州医软智能科技有限公司 Device and method for monitoring microcirculation imaging
US20160235303A1 (en) * 2013-10-11 2016-08-18 The Trustees Of Columbia University In The City Of New York System, method and computer-accessible medium for characterization of tissue
CN103622674A (en) * 2013-11-15 2014-03-12 广州医软智能科技有限公司 Minitype microcirculation imaging monitoring device and method
CN203914853U (en) * 2014-06-28 2014-11-05 吕清林 A kind of digital stomatology endoscope
CN104224135A (en) * 2014-10-20 2014-12-24 广州医软智能科技有限公司 Multilevel microcirculation condition monitoring device and method
CN104458758A (en) * 2014-12-31 2015-03-25 湘潭大学 Detection device for synthetic sapphire wafer
CN104905781A (en) * 2015-02-13 2015-09-16 林昌军 Encephalic physiological parameter collecting device and application
CN105662388A (en) * 2016-01-12 2016-06-15 冯兴怀 Microcirculation shock monitor capable of achieving rapid and repeated positioning and monitor system and method
EP3228241A1 (en) * 2016-04-08 2017-10-11 VDW GmbH Dental probe
CN206473308U (en) * 2016-06-03 2017-09-08 冯兴怀 A kind of hand-held microcirculation monitor image stabilization and probe pressure control device
CN106419854A (en) * 2016-06-03 2017-02-22 冯兴怀 Image stabilization and probe pressure control device for portable microcirculation detector
CN206044591U (en) * 2016-06-08 2017-03-29 中国美术学院 A kind of electronic oral cavity sight glass for being easy to check oneself
CN206342453U (en) * 2016-08-31 2017-07-21 黄丹莉 Ear-nose-throat department check device
CN207101615U (en) * 2017-02-20 2018-03-16 吉林大学 Fixator for tracheal cannule
US20200237231A1 (en) * 2017-02-22 2020-07-30 University Of Maryland, Baltimore Apparatus and method for tooth pulp vitality detection
CN206804477U (en) * 2017-06-14 2017-12-26 中央民族大学 A kind of measurement pipe stream mid-span particle diameter size granule grading and its optical system of distribution
US10627615B2 (en) * 2017-08-07 2020-04-21 Olympus Corporation Endoscope distal end portion, endoscope, and optical adaptor
CN107677644A (en) * 2017-08-23 2018-02-09 北京大学 A kind of detecting system and its detection method of multilayer tissue's bulk optics parameter
WO2019112090A1 (en) * 2017-12-07 2019-06-13 한국광기술원 Composite imaging device for structural/functional images of tooth
CN108452412A (en) * 2018-03-28 2018-08-28 青岛市市立医院 A kind of department of anesthesia's multichannel pars oralis pharyngis air-breather
CN109998724A (en) * 2018-10-08 2019-07-12 青岛大学 A kind of laser teeth operation device and its method
CN209733935U (en) * 2018-11-12 2019-12-06 南京市儿童医院 children external auditory canal endoscope
WO2020136445A1 (en) * 2018-12-27 2020-07-02 Feres Vieira Jose Custodio Universal extra-oral support accessory for portable microscopes
CN210542768U (en) * 2018-12-29 2020-05-19 右江民族医学院附属医院 Tracheal cannula fixer
CN209951995U (en) * 2019-03-25 2020-01-17 伍堂洪 Oropharynx air duct type tracheal catheter fixator
CN210355591U (en) * 2019-06-10 2020-04-21 梁小华 Multi-channel oropharyngeal ventilation device for anesthesia department
CN110584578A (en) * 2019-09-03 2019-12-20 奇鋐科技股份有限公司 Oral cavity detection device with replaceable detection head
CN211534942U (en) * 2019-12-20 2020-09-22 深圳市康泰健牙科器材有限公司 Antifog intraoral scanner probe sleeve
CN112336309A (en) * 2020-11-04 2021-02-09 上海交通大学 Optical fiber type sublingual microcirculation continuous monitoring device

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
于船等: "《激光兽医学》", 31 December 1990, 农业出版社 *
虞钢等: "《激光制造工艺力学》", 31 January 2012, 国防工业出版社 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022095944A1 (en) * 2020-11-04 2022-05-12 上海交通大学医学院附属瑞金医院 Parallel detection and/or hook type optical fiber transmission microcirculation monitoring device
CN113040723A (en) * 2021-06-01 2021-06-29 深圳市中医院 Tongue vein detection device and detection method
CN113040723B (en) * 2021-06-01 2021-10-08 深圳市中医院 Tongue vein detection device and detection method
WO2022252554A1 (en) * 2021-06-01 2022-12-08 深圳市中医院 Tongue vein testing device and testing method

Similar Documents

Publication Publication Date Title
US10433733B2 (en) Single-cell label-free photoacoustic flowoxigraphy in vivo
US6571117B1 (en) Capillary sweet spot imaging for improving the tracking accuracy and SNR of noninvasive blood analysis methods
AU2005310343B2 (en) Pulsed lighting imaging systems and methods
US6719686B2 (en) Fetal probe having an optical imaging device
JP4373651B2 (en) Diagnostic light irradiation device
JP2736002B2 (en) Device for in vivo measurement of optical properties of aqueous humor of the eye
US20140142404A1 (en) Single-cell label-free photoacoustic flowoxigraphy in vivo
CN114786572B (en) Parallel detection and/or hook type optical fiber transmission microcirculation monitoring device
ATE556644T1 (en) FORWARD SCANING IMAGING LIGHT FIBER PROBE
US7307258B2 (en) Terahertz system for detecting the burn degree of skin
CN112353378A (en) Microcirculation detection device and system based on parallel structure detector
JPH0431691B2 (en)
US20120301839A1 (en) Method and apparatus for the assessment of pulpal vitality using laser speckle imaging
JP2003010189A (en) Organism function information imaging device
CN112353379A (en) Probe body with hook type sensor structure and tongue bottom microcirculation detection device
US20040234187A1 (en) Method of and apparatus for measuring nonstationary oscillatory motion
US20120122052A1 (en) Medical, in Particular Dental, Diagnostic Device Having Image Capture Means
CN213821376U (en) Plug structure for microcirculation monitoring and continuous microcirculation monitoring device
US20220338747A1 (en) System and method for monitoring fluid management to a patient
JP2007054333A (en) Oct probe, and oct system
CN208892541U (en) Multispectral fundus imaging equipment
KR200447267Y1 (en) Laryngoscope having measurement system
US20240008757A1 (en) Handheld laser-based perfusion imaging apparatus and method of using said apparatus
CN217365821U (en) Fundus camera illumination unit, fundus camera optical system and ophthalmologic apparatus
CN218572188U (en) Laser speckle blood flow imaging system

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20210212